Faculty Profiles - SAWADA Tsunaki

Papers - SAWADA Tsunaki

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Objective evaluation of the therapeutic effect of ustekinumab on Crohn's disease

Yamamura, T; Nakamura, M; Murate, K; Maeda, K; Sawada, T; Mizutani, Y; Nishikawa, T; Hattori, S; Yamamoto, K; Pu, LZCT; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Fujishiro, M

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 34 page： 145 - 145 2019.9

Specific members of gut microbiota predict mucosal healing in Crohn's disease

Hattori, S; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Yamamoto, K; Pu, LZCT; Honda, T; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Fujishiro, M

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 34 page： 152 - 152 2019.9

CLINICAL SIGNIFICANCE OF THE PATENCY OF GASTROINTESTINAL TRACT IN CROHN'S DISEASE EVALUATED BY PATENCY CAPSULE

Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Kuno, T; Yamada, K; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Hirooka, Y

GASTROINTESTINAL ENDOSCOPY Vol. 89 ( 6 ) page： AB333 - AB333 2019.6

Yamada, K; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Niwa, Y; Ishikawa, E; Otsuka, H; Suzuki, H; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Hotta, N; Pu, LZCT; Hirooka, Y

GASTROINTESTINAL ENDOSCOPY Vol. 89 ( 6 ) page： AB155 - AB155 2019.6

USEFULNESS OF THE FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE IN THE DIAGNOSIS OF INVASION DEPTH OF COLORECTAL NEOPLASIA

Kuno, T; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Mizutani, Y; Suzuki, H; Esaki, M; Ishikawa, T; Furukawa, K; Ohno, E; Kawashima, H; Miyahara, R; Hirooka, Y

GASTROINTESTINAL ENDOSCOPY Vol. 89 ( 6 ) page： AB324 - AB324 2019.6

今月の主題知っておきたい小腸疾患主題小腸の非腫瘍性疾患-小腸リンパ管拡張症

中村正直, 山村健史, 前田啓子, 澤田つな騎, 水谷泰之, 丹羽慶樹, 石川恵里, 大塚裕之, 鈴木悠土, 西川貴広, 石田哲也, 久野剛史, 服部峻, 山田啓策, 廣岡芳樹, 藤城光弘

胃と腸 Vol. 54 ( 4 ) page： 532 - 536 2019.4

Utility of linked color imaging for endoscopic diagnosis of early gastric cancer

Fujiyoshi, T; Miyahara, R; Funasaka, K; Furukawa, K; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Nakaguro, M; Nakatochi, M; Hirooka, Y

WORLD JOURNAL OF GASTROENTEROLOGY Vol. 25 ( 10 ) page： 1248 - 1258 2019.3

Language：English Publisher：World Journal of Gastroenterology

BACKGROUND: Linked color imaging (LCI) is a method of endoscopic imaging that emphasizes slight differences in red mucosal color. AIM: To evaluate LCI in diagnostic endoscopy of early gastric cancer and to compare LCI and pathological findings. METHODS: Endoscopic images were obtained for 39 patients (43 lesions) with early gastric cancer. Three endoscopists evaluated lesion recognition with white light imaging (WLI) and LCI. Color values in Commission Internationale de l'Eclairage (CIE) 1976 L*a*b* color space were used to calculate the color difference (ΔE) between cancer lesions and non-cancer areas. After endoscopic submucosal dissection, blood vessel density in the surface layer of the gastric epithelium was evaluated pathologically. The identical region of interest was selected for analyses of endoscopic images (WLI and LCI) and pathological analyses. RESULTS: LCI was superior for lesion recognition (P < 0.0001), and ΔE between cancer and non-cancer areas was significantly greater with LCI than WLI (29.4 vs 18.6, P < 0.0001). Blood vessel density was significantly higher in cancer lesions (5.96% vs 4.15%, P = 0.0004). An a* cut-off of ≥ 24 in CIE 1976 L*a*b* color space identified a cancer lesion using LCI with sensitivity of 76.7%, specificity of 93.0%, and accuracy of 84.9%. CONCLUSION: LCI is more effective for recognition of early gastric cancer compared to WLI as a result of improved visualization of changes in redness. Surface blood vessel density was significantly higher in cancer lesions, and this result is consistent with LCI image analysis.

DOI： 10.3748/wjg.v25.i10.1248

Web of Science

Scopus

PubMed

腸リンパ管拡張症の診断と治療

中村正直, 山村健史, 前田啓子, 澤田つな騎, 水谷泰之, 藤城光弘

日本小腸学会学術集会プログラム・抄録集 Vol. 3 ( 0 ) page： 34_2 - 34_2 2019

Language：Japanese Publisher：日本小腸学会

【背景・目的】　小腸内視鏡診断の進歩により腸リンパ管拡張症（Intestinal lymphangiectasia：IL）を含む蛋白漏出性腸症の小腸精査が可能になった。本研究の目的はILの臨床経過を後ろ向きに評価し、その特徴を明らかにしたうえでより良い治療法を模索することであった。【対象と方法】　対象は2003年6月から2019年6月までにILと診断された17例（男性9例、女性8例、発症年齢は中央値37歳、0-75歳）であった。ILの診断は蛋白漏出性腸症と診断され且つ内視鏡下生検もしくは剖検にて病理学的に腸リンパ管拡張を認めたもので、他疾患が否定的であったものとした。白色絨毛、散布性白点を有する白色絨毛群（WV）と、異常なしもしくは軽度絨毛腫大、ケルクリング襞腫大を認める非白色絨毛群（NWV）に分けて臨床成績を比較検討した。【結果】　WV、NWVは10例、7例であった。平均血清アルブミン値（g/dl）はWV：NWV = 2.0：1.2でNWVにおいて有意に低かった（P = 0.0061）。平均α1アンチトリプシンクリアランスはWV：NWV = 132：284（P = 0.0509）であった。ステロイド治療への反応はWV：NWV = 2/7：6/6 例でみられた。平均観察期間48箇月において1例のILが影響した死亡例を経験したが、重篤な真菌感染症によるものであった。【結論】　NWV群は蛋白漏出は多いがステロイドへの反応がWV群よりも良好であった。治療のゴールドスタンダードは存在せず可能な可能で効果があるものを続けることが現状であった。

DOI： 10.32264/shocho.3.0_34_2

CiNii Research

A CASE OF MULTIPLE HEMANGIOMAS OF THE SMALL INTESTINE TREATED BY SCLEROTHERAPY USING DOUBLE-BALLOON ENTEROSCOPY

YAMADA Keisaku, YAMAMURA Takeshi, NAKAMURA Masanao, SAWADA Tsunaki, MIZUTANI Yasuyuki, MAEDA Keiko, FURUKAWA Kazuhiro, MIYAHARA Ryoji, YOKOI Takio, HIROOKA Yoshiki

GASTROENTEROLOGICAL ENDOSCOPY Vol. 61 ( 6 ) page： 1231 - 1236 2019

Language：Japanese Publisher：Japan Gastroenterological Endoscopy Society

A 70-year-old male was referred to our department due to melena which began one month previously. Esophagogastroduodenoscopy and colonoscopy were performed, but no signs of active bleeding were found. Therefore, capsule endoscopy was performed to check for small intestinal lesions. Capsule endoscopy revealed multiple protruded lesions and bloody intestinal fluid in a lesion in the upper ileum. Double-balloon enteroscopy revealed multiple protruded lesions suspicious of being hemangioma. Endoscopic mucosal resection of a lesion was performed, and it was finally diagnosed as capillary hemangioma. Sclerotherapy was performed by injecting polidocanol in the multiple hemangiomas. After this treatment, there was no melena and the follow-up endoscopy showed decreased size of the lesions. Thus, sclerotherapy was found to be useful in the treatment of multiple hemangiomas in the small intestine.

DOI： 10.11280/gee.61.1231

Scopus

CiNii Research

Lewis Score on Capsule Endoscopy as a Predictor of the Risk for Crohn's Disease-Related Emergency Hospitalization and Clinical Relapse in Patients with Small Bowel Crohn's Disease

Nishikawa, T; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Hirooka, Y

GASTROENTEROLOGY RESEARCH AND PRACTICE Vol. 2019 page： 4274257 2019

Language：English Publisher：Gastroenterology Research and Practice

Background. Small bowel capsule endoscopy (CE) is a useful tool for evaluating the mucosal changes in patients with Crohn’s disease (CD). The Lewis score (LS) on CE could be used to objectively assess the inflammatory activity of the small bowel mucosa. However, only few reports on the correlation between the LS and CD prognosis exist. This study is aimed at evaluating the clinical significance of the LS by determining the cutoff value of the LS that could predict CD-related emergency hospitalization. Methods. This retrospective single-center study included 125 patients who underwent CE for small bowel CD. Eighty-six patients whose treatment was not changed after CE were analyzed. Inflammatory activity was assessed with the LS. We examined the clinical course of the patients who could be observed for 1 year after CE and investigated the LS cutoff value that could predict CD-related emergency hospitalization within 1 year. We also examined the hospitalization-free and clinical relapse-free rates using the LS cutoff value and evaluated the factors related to emergency hospitalization. Results. The LS cutoff value that could predict CD-related emergency hospitalization within 1 year was 264 (area under the curve, 0.92 (P < 0 001); sensitivity, 0.80; and specificity, 0.94). The cumulative hospitalization-free rate and cumulative clinical relapse-free rate were significantly higher in patients with a LS < 264 (P < 0 001). Multivariate analysis showed that a LS < 264 was a statistically significant factor (P = 0 001; 95% CI, 0.010–0.308). Conclusion. A LS of 264 is a useful cutoff value that could predict CD-related emergency hospitalization. This LS cutoff value may help determine treatment strategies for CD.

DOI： 10.1155/2019/4274257

Web of Science

Scopus

PubMed

Validity of Capsule Endoscopy in Monitoring Therapeutic Interventions in Patients with Crohn's Disease

Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Koulaouzidis Anastasios, Hirooka Yoshiki

JOURNAL OF CLINICAL MEDICINE Vol. 7 ( 10 ) 2018.10

THE DIAGNOSTIC ABILITY AND PITFALL OF JNET(JAPAN NBI EXPERT TEAM)CLASSIFICATION IN TRAINEES

Suzuki Hiroto, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Niwa Yoshiki, Uchida Genta, Otsuka Hiroyuki, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keisaku, Hattori Shun, Kajikawa Go, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

GASTROINTESTINAL ENDOSCOPY Vol. 87 ( 6 ) page： AB489 - AB490 2018.6

EVALUATION OF LOCAL RECURRENCE AFTER COLD POLYPECTOMY COMPARED WITH CONVENTIONAL HOT POLYPECTOMY IN A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL

Yamamura, T; Saito, M; Watanabe, O; Nakamura, M; Matsushita, M; Sawada, T; Mizutani, Y; Niwa, Y; Ishikawa, E; Suzuki, H; Otsuka, H; Uchida, G; Nishikawa, T; Ishida, T; Kuno, T; Yamada, K; Hattori, S; Hashiguchi, H; Suhara, H; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Miyahara, R; Kawashima, H; Hirooka, Y; Goto, H

GASTROINTESTINAL ENDOSCOPY Vol. 87 ( 6 ) page： AB478 - AB478 2018.6

FEM simulation of local field enhancement close to lamination interface of permittivity-graded material

Kurimoto, M; Ozaki, H; Sawada, T; Funabashi, T; Kato, T; Suzuoki, Y

ELECTRONICS AND COMMUNICATIONS IN JAPAN Vol. 101 ( 6 ) page： 48 - 57 2018.6

Publisher：Electronics and Communications in Japan

For size reduction of gas insulated switchgears (GIS), application of permittivity-graded material to insulating spacer has been studied. The electric-field-enhancement close to the lamination interface of the permittivity-graded material obtained by laminating epoxy composites with different permittivities was investigated. The FEM simulation revealed that the increase of the layer number of the permittivity-graded material could reduce the field enhancement close by the lamination interface, even when considering electric field distortion near the individual high-permittivity particles filled in each layer.

DOI： 10.1002/ecj.12074

Web of Science

Scopus

Making decision to treat with infliximab by the result of periodic surveillance with double-balloon endoscopy after ilectomy can obtain mucosal healing and avoid re-operation on patients with Crohn's disease for a long-term follow-up study

Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Saito Masashi, Matsuura Rinzaburou, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keishi, Kuno Takeshi, Hattori Shun, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 32 page： 287 - 287 2017.9

Clinical factors related to false-positive rates of patency capsule examination

Sawada Tsunaki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Elzaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY Vol. 10 ( 8 ) page： 589 - 598 2017.8

One Year Follow-Up After Cold Polypectomy Compared With Hot Polypectomy for Small Colorectal Polyps - a Prospective Randomized Controlled Trial

Saito Masashi, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

GASTROINTESTINAL ENDOSCOPY Vol. 85 ( 5 ) page： AB365 - AB366 2017.5

Establishment of a New Scoring System for Predicting the Necessity of Double-Balloon Endoscopy in Obscure Gastrointestinal Bleeding

Uchida Genta, Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

GASTROINTESTINAL ENDOSCOPY Vol. 85 ( 5 ) page： AB300 - AB300 2017.5

The Study of Diagnostic Ability for the Colorectal Neoplasms by Imaged Enhanced Endoscopy Using by JNET (Japan NBI Expert Team) Classification

Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Matsuura Rinzaburo, Saito Masashi, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

GASTROINTESTINAL ENDOSCOPY Vol. 85 ( 5 ) page： AB402 - AB402 2017.5

Clinical Factors Related to False Positive Rates of Patency Capsule Examination

Sawada Tsunaki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Goto Hidemi, Hirooka Yoshiki

GASTROINTESTINAL ENDOSCOPY Vol. 85 ( 5 ) page： AB305 - AB305 2017.5

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Papers - SAWADA Tsunaki