Faculty Profiles - SAWADA Tsunaki

Papers - SAWADA Tsunaki

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A novel prediction tool for mortality in patients with acute lower gastrointestinal bleeding requiring emergency hospitalization: a large multicenter study.

Tominaga N, Sadashima E, Aoki T, Fujita M, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Sato Y, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Hikichi T, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kobayashi K, Matsuhashi T, Komaki Y, Miki K, Watanabe K, Kaise M, Nagata N

Scientific reports Vol. 14 ( 1 ) page： 5367 2024.3

High risk stigmata and treatment strategy for acute lower gastrointestinal bleeding: a nationwide study in Japan.

Aoki T, Sadashima E, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Hayakawa Y, Fujishiro M, Kaise M, Nagata N, CODE BLUE-J Study collaborators

Endoscopy 2024.2

Risk factors for rebleeding in gastroduodenal ulcers

Ito, N; Funasaka, K; Fujiyoshi, T; Nishida, K; Satta, Y; Furukawa, K; Kakushima, N; Furune, S; Ishikawa, E; Mizutani, Y; Sawada, T; Maeda, K; Ishikawa, T; Yamamura, T; Ohno, E; Nakamura, M; Miyahara, R; Sasaki, Y; Haruta, JI; Fujishiro, M; Kawashima, H

IRISH JOURNAL OF MEDICAL SCIENCE Vol. 193 ( 1 ) page： 173 - 179 2024.2

特集 IBD診療-ますます増えた薬剤の選択とさらなる進化の展望 1.治療薬の使い分けの総論と各論(4)中等症UCにおけるバイオ製剤/JAK阻害薬の使い分け-抗IL-23抗体も含めて

中村正直, 山村健史, 前田啓子, 澤田つな騎, 石川恵里, 川嶋啓揮

臨床消化器内科 Vol. 39 ( 2 ) page： 140 - 146 2024.1

BALLOON ENDOSCOPY TO EXAMINE SMALL INTESTINAL LESIONS IN PATIENTS WITH CROHN’S DISEASE

SAWADA Tsunaki, NAKAMURA Masanao, KAWASHIMA Hiroki

GASTROENTEROLOGICAL ENDOSCOPY Vol. 66 ( 1 ) page： 16 - 28 2024

Language：Japanese Publisher：Japan Gastroenterological Endoscopy Society

<p>Small intestinal lesions in Crohnʼs disease can cause obstructions and are known to have a high surgery rate. Management of small intestinal lesions is essential in treating Crohnʼs disease. In clinical practice, balloon-assisted endoscopy can assist with diagnosing Crohnʼs disease, which presents with lesions in areas that are difficult to visualize with a conventional ileocolonoscopy, and facilitate evaluation and monitoring of therapeutic effects on small bowel lesions. In addition, balloon dilation for symptomatic small bowel stricture has been reported to have a high procedural success rate and favorable long-term efficacy in lesions that meet the indication criteria, such as the absence of ulcers. Compared to other methods of evaluating small lesions, it has high accuracy for detecting small intestinal lesions and is the only method that enables tissue biopsy and endoscopic treatment. On the other hand, it is invasive, and adverse events such as gastrointestinal perforation, bleeding, and pancreatitis have been reported. In clinical practice, future discussions are expected on case-dependent selection of an optimal modality among various available modalities for evaluation and management of Crohnʼs disease, including balloon-assisted endoscopy.</p>

DOI： 10.11280/gee.66.16

CiNii Research

Monoclonal Antibody Against Mature Interleukin-18 Ameliorates Colitis in Mice and Improves Epithelial Barrier Function

Ikegami, S; Maeda, K; Urano, T; Mu, JX; Nakamura, M; Yamamura, T; Sawada, T; Ishikawa, E; Yamamoto, K; Muto, H; Oishi, A; Iida, T; Mizutani, Y; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Ishigami, M; Kawashima, H

INFLAMMATORY BOWEL DISEASES 2023.12

LONG-HOSP Score: A Novel Predictive Score for Length of Hospital Stay in Acute Lower Gastrointestinal Bleeding - A Multicenter Nationwide Study

Fujita, M; Aoki, T; Manabe, N; Ito, Y; Kobayashi, K; Yamauchi, A; Yamada, A; Omori, J; Ikeya, T; Aoyama, T; Tominaga, N; Sato, Y; Kishino, T; Ishii, N; Sawada, T; Murata, M; Takao, A; Mizukami, K; Kinjo, K; Fujimori, S; Uotani, T; Sato, H; Suzuki, S; Narasaka, T; Hayasaka, J; Funabiki, T; Kinjo, Y; Mizuki, A; Kiyotoki, S; Mikami, T; Gushima, R; Fujii, H; Fuyuno, Y; Gunji, N; Toya, Y; Narimatsu, K; Nagaike, K; Kinjo, T; Sumida, Y; Funakoshi, S; Kobayashi, K; Matsuhashi, T; Komaki, Y; Miki, K; Watanabe, K; Ayaki, M; Murao, T; Suehiro, M; Shiotani, A; Hata, J; Haruma, K; Kaise, M; Nagata, N

DIGESTION Vol. 104 ( 6 ) page： 446 - 459 2023.12

Weekend effect on clinical outcomes of acute lower gastrointestinal bleeding: A large multicenter cohort study in Japan

Hayasaka, J; Kikuchi, D; Ishii, N; Kobayashi, K; Yamauchi, A; Yamada, A; Omori, J; Ikeya, T; Aoyama, T; Tominaga, N; Sato, Y; Kishino, T; Sawada, T; Murata, M; Takao, A; Mizukami, K; Kinjo, K; Fujimori, S; Uotani, T; Fujita, M; Sato, H; Suzuki, S; Narasaka, T; Funabiki, T; Kinjo, Y; Mizuki, A; Kiyotoki, S; Mikami, T; Gushima, R; Fujii, H; Fuyuno, Y; Gunji, N; Toya, Y; Narimatsu, K; Manabe, N; Nagaike, K; Kinjo, T; Sumida, Y; Funakoshi, S; Kobayashi, K; Matsuhashi, T; Komaki, Y; Miki, K; Watanabe, K; Odagiri, H; Hoteya, S; Kaise, M; Nagata, N

DIGESTIVE DISEASES Vol. 41 ( 6 ) page： 890 - 899 2023.12

Long-term Risks of Recurrence After Hospital Discharge for Acute Lower Gastrointestinal Bleeding: A Large Nationwide Cohort Study

Sato, Y; Aoki, T; Sadashima, E; Nakamoto, Y; Kobayashi, K; Yamauchi, A; Yamada, A; Omori, J; Ikeya, T; Aoyama, T; Tominaga, N; Kishino, T; Ishii, N; Sawada, T; Murata, M; Takao, A; Mizukami, K; Kinjo, K; Fujimori, S; Uotani, T; Fujita, M; Sato, H; Suzuki, S; Narasaka, T; Hayasaka, J; Funabiki, T; Kinjo, Y; Mizuki, A; Kiyotoki, S; Mikami, T; Gushima, R; Fujii, H; Fuyuno, Y; Gunji, N; Toya, Y; Narimatsu, K; Manabe, N; Nagaike, K; Kinjo, T; Sumida, Y; Funakoshi, S; Kobayashi, K; Matsuhashi, T; Komaki, Y; Maehata, T; Tateishi, K; Kaise, M; Nagata, N

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY Vol. 21 ( 13 ) page： 3258 - + 2023.12

Characteristics, outcomes, and risk factors of surgery for acute lower gastrointestinal bleeding: nationwide cohort study of 10,342 hematochezia cases

Omori, J; Kaise, M; Nagata, N; Aoki, T; Kobayashi, K; Yamauchi, A; Yamada, A; Ikeya, T; Aoyama, T; Tominaga, N; Sato, Y; Kishino, T; Ishii, N; Sawada, T; Murata, M; Takao, A; Mizukami, K; Kinjo, K; Fujimori, S; Uotani, T; Fujita, M; Sato, H; Suzuki, S; Narasaka, T; Hayasaka, J; Funabiki, T; Kinjo, Y; Mizuki, A; Kiyotoki, S; Mikami, T; Gushima, R; Fujii, H; Fuyuno, Y; Hikichi, T; Toya, Y; Narimatsu, K; Manabe, N; Nagaike, K; Kinjo, T; Sumida, Y; Funakoshi, S; Kobayashi, K; Matsuhashi, T; Komaki, Y; Miki, K; Watanabe, K; Iwakiri, K

JOURNAL OF GASTROENTEROLOGY Vol. 59 ( 1 ) page： 24 - 33 2023.11

今月の主題小腸画像診断のトピックス主題バルーン内視鏡:ダブルバルーン内視鏡を中心に-腫瘍性疾患と炎症性疾患に対する診断法の有用性と限界

中村正直, 山村健史, 前田啓子, 澤田つな騎, 石川恵里, 村手健太郎, 長谷川一成, 池上脩二, 山下彩子, 河村達哉, 大岩恵祐, 八田勇輔, 平松美緒, 廣瀬崇, 古川和宏, 川嶋啓揮

胃と腸 Vol. 58 ( 11 ) page： 1462 - 1469 2023.11

Early feeding reduces length of hospital stay in patients with acute lower gastrointestinal bleeding: A large multicentre cohort study

Kishino, T; Aoki, T; Sadashima, E; Kobayashi, K; Yamauchi, A; Yamada, A; Omori, J; Ikeya, T; Aoyama, T; Tominaga, N; Sato, Y; Ishii, N; Sawada, T; Murata, M; Takao, A; Mizukami, K; Kinjo, K; Fujimori, S; Uotani, T; Fujita, M; Sato, H; Suzuki, S; Narasaka, T; Hayasaka, J; Funabiki, T; Kinjo, Y; Mizuki, A; Kiyotoki, S; Mikami, T; Gushima, R; Fujii, H; Fuyuno, Y; Gunji, N; Toya, Y; Narimatsu, K; Manabe, N; Nagaike, K; Kinjo, T; Sumida, Y; Funakoshi, S; Kobayashi, K; Matsuhashi, T; Komaki, Y; Kaise, M; Nagata, N

COLORECTAL DISEASE Vol. 25 ( 11 ) page： 2206 - 2216 2023.11

Real-World Effectiveness and Risk Factors for Discontinuation of Ustekinumab in Ulcerative Colitis.

Uchida G, Nakamura M, Yamamura T, Maeda K, Sawada T, Ishikawa E, Furukawa K, Iida T, Mizutani Y, Yamao K, Ishikawa T, Ishizu Y, Honda T, Ishigami M, Kawashima H

Inflammatory intestinal diseases Vol. 8 ( 2 ) page： 60 - 68 2023.10

Development and validation of a novel model for predicting stigmata of recent hemorrhage in acute lower gastrointestinal bleeding: Multicenter nationwide study

Aoki, T; Yamada, A; Kobayashi, K; Yamauchi, A; Omori, J; Ikeya, T; Aoyama, T; Tominaga, N; Sato, Y; Kishino, T; Ishii, N; Sawada, T; Murata, M; Takao, A; Mizukami, K; Kinjo, K; Fujimori, S; Uotani, T; Fujita, M; Sato, H; Suzuki, S; Narasaka, T; Hayasaka, J; Funabiki, T; Kinjo, Y; Mizuki, A; Fujishiro, M; Kaise, M; Nagata, N

DIGESTIVE ENDOSCOPY Vol. 35 ( 6 ) page： 777 - 789 2023.9

Clinical characteristics of Dieulafoy's lesion in the small bowel diagnosed and treated by double-balloon endoscopy

Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Furukawa, K; Iida, T; Mizutani, Y; Yamao, K; Ishikawa, T; Honda, T; Ishigami, M; Kawashima, H

BMC GASTROENTEROLOGY Vol. 23 ( 1 ) page： 290 2023.8

Outcomes and recurrent bleeding risks of detachable snare and band ligation for colonic diverticular bleeding: a multicenter retrospective cohort study

Yamauchi, A; Ishii, N; Yamada, A; Kobayashi, K; Omori, J; Ikeya, T; Aoyama, T; Tominaga, N; Sato, Y; Kishino, T; Sawada, T; Murata, M; Takao, A; Mizukami, K; Kinjo, K; Fujimori, S; Uotani, T; Fujita, M; Sato, H; Suzuki, S; Narasaka, T; Hayasaka, J; Funabiki, T; Kinjo, Y; Mizuki, A; Kiyotoki, S; Mikami, T; Gushima, R; Fujii, H; Fuyuno, Y; Gunji, N; Toya, Y; Narimatsu, K; Manabe, N; Nagaike, K; Kinjo, T; Sumida, Y; Funakoshi, S; Kobayashi, K; Matsuhashi, T; Komaki, Y; Miki, K; Watanabe, K; Mori, Y; Osawa, K; Nakagami, S; Kawai, Y; Yoshikawa, T; Kaise, M; Nagata, N

GASTROINTESTINAL ENDOSCOPY Vol. 98 ( 1 ) page： 59 - 72.e7 2023.7

Multicenter propensity score-matched analysis comparing short <i>versus</i> long cap-assisted colonoscopy for acute hematochezia

Kobayashi, M; Akiyama, S; Narasaka, T; Kobayashi, K; Yamauchi, A; Yamada, A; Omori, J; Ikeya, T; Aoyama, T; Tominaga, N; Sato, Y; Kishino, T; Ishii, N; Sawada, T; Murata, M; Takao, A; Mizukami, K; Kinjo, K; Fujimori, S; Uotani, T; Fujita, M; Sato, H; Suzuki, S; Hayasaka, J; Funabiki, T; Kinjo, Y; Mizuki, A; Kiyotoki, S; Mikami, T; Gushima, R; Fujii, H; Fuyuno, Y; Gunji, N; Toya, Y; Narimatsu, K; Manabe, N; Nagaike, K; Kinjo, T; Sumida, Y; Funakoshi, S; Kobayashi, K; Matsuhashi, T; Komaki, Y; Tsuchiya, K; Kaise, M; Nagata, N

JGH OPEN Vol. 7 ( 7 ) page： 487 - 496 2023.7

Diagnostic Performance of Endocytoscopy for Esophageal Eosinophilia

Hida, E; Muroi, K; Kakushima, N; Furune, S; Ishikawa, E; Mizutani, Y; Sawada, T; Keiko, M; Yamamura, T; Ishikawa, T; Furukawa, K; Ohno, E; Nakamura, M; Nishida, K; Fujishiro, M; Kawashima, H

DIGESTION Vol. 104 ( 3 ) page： 202 - 211 2023.6

Efficacy of 1-kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double-blind, placebo-controlled pilot study

Ikegami, S; Nakamura, M; Honda, T; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Yamamoto, K; Furune, S; Ishikawa, T; Furukawa, K; Ohno, E; Ishigami, M; Kinoshita, F; Kadota, Y; Tochio, T; Shimomura, Y; Hirooka, Y; Kawashima, H

ALIMENTARY PHARMACOLOGY & THERAPEUTICS Vol. 57 ( 11 ) page： 1249 - 1257 2023.6

Language：English Publisher：Alimentary Pharmacology and Therapeutics

Background: Ulcerative colitis involves an excessive immune response to intestinal bacteria. Whether administering prebiotic 1-kestose is effective for active ulcerative colitis remains controversial. Aims: This randomised, double-blind, placebo-controlled pilot trial investigated the efficacy of 1-kestose against active ulcerative colitis. Methods: Forty patients with mild to moderate active ulcerative colitis were randomly treated with 1-kestose (N = 20) or placebo (maltose, N = 20) orally for 8 weeks in addition to the standard treatment. The Lichtiger clinical activity index and Ulcerative Colitis Endoscopic Index of Severity were determined. Faecal samples were analysed to evaluate the gut microbiome and metabolites. Results: The clinical activity index at week 8 was significantly lower in the 1-kestose group than in the placebo group (3.8 ± 2.7 vs. 5.6 ± 2.1, p = 0.026). Clinical remission and response rates were higher in the 1-kestose group than in the placebo group (remission: 55% vs. 20%, p = 0.048; response: 60% vs. 25%, p = 0.054). The Ulcerative Colitis Endoscopic Index of Severity at week 8 was not significantly different (2.8 ± 1.6 vs. 3.5 ± 1.6, p = 0.145). Faecal analysis showed significantly reduced alpha-diversity in the 1-kestose group, with a decreased relative abundance of several bacteria, including Ruminococcus gnavus group. The short-chain fatty acid levels were not significantly different between the groups. The incidence of adverse events was comparable between the groups. Discussion: Oral 1-kestose is well tolerated and provides clinical improvement for patients with mild to moderate ulcerative colitis through modulation of the gut microbiome.

DOI： 10.1111/apt.17387

Web of Science

Scopus

PubMed

ENDOSCOPIC TREATMENT OF DUODENAL NEUROENDOCRINE TUMORS

Furukawa, K; Furune, S; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Nakamura, M; Kawashima, H

GASTROINTESTINAL ENDOSCOPY Vol. 97 ( 6 ) page： AB1211 - AB1212 2023.6

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Papers - SAWADA Tsunaki