Updated on 2022/05/13

写真a

 
WATANABE Nobuyuki
 
Organization
Nagoya University Hospital Gastroenterological Surgery 1 Assistant Professor
Graduate School
Graduate School of Medicine
Title
Assistant Professor
External link

Degree 1

  1. 医学博士 ( 2017.9   名古屋大学 ) 

Research Areas 1

  1. Life Science / Digestive surgery

 

Papers 31

  1. The Impact of Stump Closure Techniques on Pancreatic Fistula Stratified by the Thickness of the Pancreas in Distal Pancreatectomy. Reviewed International journal

    Watanabe N, Yamamoto Y, Sugiura T, Okamura Y, Ito T, Ashida R, Uesaka K

    Digestive surgery   Vol. 37 ( 4 ) page: 340 - 347   2020

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000505061

    PubMed

  2. Postoperative Pancreatic Fistula in Surgery for Perihilar Cholangiocarcinoma Reviewed International journal

    Watanabe Nobuyuki, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Nagino Masato

    WORLD JOURNAL OF SURGERY   Vol. 43 ( 12 ) page: 3094 - 3100   2019.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:World Journal of Surgery  

    DOI: 10.1007/s00268-019-05127-3

    Web of Science

    Scopus

  3. A predictive scoring system for insufficient liver hypertrophy after preoperative portal vein embolization. Reviewed International journal

    Watanabe N, Yamamoto Y, Sugiura T, Okamura Y, Ito T, Ashida R, Aramaki T, Uesaka K

    Surgery   Vol. 163 ( 5 ) page: 1014 - 1019   2018.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.surg.2017.11.026

    PubMed

  4. 特集 直腸癌局所再発に挑む-最新の治療戦略と手術手技 総論 局所再発直腸癌の治療方針-臓器温存手術や遠隔転移併存症例の手術適応も含めて

    村田 悠記, 上原 圭, 小倉 淳司, 杉田 静紀, 渡辺 伸元, 砂川 真輝, 尾上 俊介, 宮田 一志, 山口 淳平, 水野 隆史, 伊神 剛, 國料 俊男, 横山 幸浩, 江畑 智希

    臨床外科   Vol. 77 ( 5 ) page: 514 - 519   2022.5

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    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1407213704

    CiNii Research

  5. 特集 Borderline resectableとは? II. 各論 8.肝門部領域胆管癌におけるborderline resectableとは?

    水野 隆史, 尾上 俊介, 渡辺 伸元, 山口 淳平, 砂川 正輝, 上原 圭, 江畑 智希

    外科   Vol. 84 ( 6 ) page: 670 - 678   2022.5

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    Publisher:南江堂  

    DOI: 10.15106/j_geka84_670

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  6. 特集 高難度肝胆膵外科手術アトラス2022 Ⅱ 各論 B 胆道 3 血管合併切除を伴う胆道癌手術

    水野 隆史, 尾上 俊介, 渡辺 伸元, 江畑 智希

    手術   Vol. 76 ( 4 ) page: 561 - 569   2022.4

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    Publisher:金原出版  

    DOI: 10.18888/op.0000002718

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  7. Two Resected Cases of Cholangiocarcinoma with a Small Cell Carcinoma Component

    Minami Takayuki, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Igami Tsuyoshi, Uehara Kay, Miyata Kazushi, Yokoyama Yukihiro, Ebata Tomoki

    The Japanese Journal of Gastroenterological Surgery   Vol. 55 ( 4 ) page: 240 - 250   2022.4

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    Language:Japanese   Publisher:The Japanese Society of Gastroenterological Surgery  

    DOI: 10.5833/jjgs.2021.0083

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  8. Improvement of surgery, perioperative management, adjuvant therapy for biliary tract cancer patients

    Mizuno Takashi, Onoe Shunsuke, Watanabe Nobuyuki, Igami Tsuyoshi, Yokoyama Yukihiro, Ebata Tomoki

    Tando   Vol. 36 ( 1 ) page: 66 - 76   2022.3

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    Language:Japanese   Publisher:Japan Biliary Association  

    DOI: 10.11210/tando.36.66

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  9. 特集 胆道癌治療の最前線 II. 各論 4.肝外胆管癌に対する手術術式と適応

    尾上 俊介, 水野 隆史, 渡辺 伸元, 横山 幸浩, 國料 俊男, 伊神 剛, 上原 圭, 山口 淳平, 宮田 一志, 砂川 真輝, 小倉 淳司, 江畑 智希

    外科   Vol. 84 ( 2 ) page: 136 - 141   2022.2

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    Publisher:南江堂  

    DOI: 10.15106/j_geka84_136

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  10. Combined Vascular Resection for Locally Advanced Perihilar Cholangiocarcinoma Reviewed

    Mizuno Takashi, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Kamei Yuzuru, Nagino Masato

    ANNALS OF SURGERY   Vol. 275 ( 2 ) page: 382 - 390   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Annals of Surgery  

    Objective:To evaluate the efficacy and safety of combined vascular resection (VR) in advanced perihilar cholangiocarcinoma (PHC).Summary of Background Data:Hepatectomy combined with portal vein resection (PVR) and/or hepatic artery resection (HAR) is technically demanding but an option only for tumor eradication against PHC involving the hilar hepatic inflow vessels; however, its efficacy and safety have not been well evaluated.Methods:Patients diagnosed with PHC during 2001-2018 were included. Patients who underwent resection were divided according to combined VR. Patients undergoing VR were subdivided according to type of VR. Postoperative outcomes and OS were compared between patient groups.Results:Among the 1055 consecutive patients, 787 (75%) underwent resection (without VR: N = 484, PVR: N = 157, HAR: N = 146). The incidences of postoperative complications and mortality were 49% (without VR vs with VR, 48% vs 50%; P= 0.715) and 2.1% (without VR vs with VR, 1.2% vs 3.6%; P= 0.040), respectively. The OS of patients who underwent resection with VR (median, 30 months) was shorter than that of those who underwent resection without VR (median, 61 months; P < 0.0001); however, it was longer than that of those who did not undergo resection (median, 10 months; P < 0.0001). OS was not significantly different between those who underwent PVR and those who underwent HAR (median, 29 months vs 34 months; P = 0.517).Conclusion:VR salvages a large number of patients from having locally advanced PHC that is otherwise unresectable and is recommended if the hilar hepatic inflow vessels are reconstructable, providing acceptable surgical outcomes and substantial survival benefits.

    DOI: 10.1097/SLA.0000000000004322

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  11. A long-term survivor of advanced retroperitoneal dedifferentiated liposarcoma: a successful multimodal approach with extended resection and chemotherapy Reviewed

    Nakahashi Koichi, Yokoyama Yukihiro, Fukaya Masahide, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Ebata Tomoki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 1 ) page: 200 - 207   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nagoya Journal of Medical Science  

    Surgical resection is the mainstay of treatment for retroperitoneal liposarcoma (RPLS). Herein, we describe a case of dedifferentiated RPLS successfully treated with an extended surgical approach with adjuvant chemotherapy. A 61-year-old male was referred to our hospital with a chief complaint of chest tightness. Abdominal computed tomography revealed a large retroperitoneal tumor, 11 cm in diameter, extensively invading the surrounding organs: the celiac axis, the splenic artery, the pancreatic body and tail, the lesser curvature of the stomach and the left adrenal gland. Endoscopic ultrasound-guided fine-needle aspiration biopsy confirmed dedifferentiated liposarcoma, suggesting aggressive tumor biology. We performed total gastrectomy combined with distal pancreatectomy with celiac axis and left adrenal gland resection with a curative intent. The postoperative course was almost uneventful. As the pathological findings indicated a positive margin with a well-differentiated liposarcoma component, we added adjuvant chemotherapy with four cycles of doxorubicin and ifosfamide (AI). Five years after primary surgery, regular follow-up CT demonstrated a pulmonary hilar lymph node enlargement and a tumor at paraesophageal locations. After downsizing chemotherapy with eribulin followed by pazopanib, he underwent partial esophagectomy with dissection of the paraesophageal tumor. The pathological findings indicated recurrence of dedifferentiated liposarcoma with a tumor-free surgical margin. He is currently alive without any evidence of recurrence almost 7 years after the first surgery and 15 months after the second surgery. The long-term survival gained in this patient indicates that extended resections and adjuvant chemotherapy could prolong survival in patients even with RPLS with dedifferentiated tumor histology

    DOI: 10.18999/nagjms.84.1.200

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  12. Superiority of clinical American Joint Committee on Cancer T classification for perihilar cholangiocarcinoma International journal

    Yamada Mihoko, Mizuno Takashi, Yamaguchi Junpei, Yokoyama Yukihiro, Igami Tsuyoshi, Onoe Shunsuke, Watanabe Nobuyuki, Uehara Kay, Matsuo Keitaro, Ebata Tomoki

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES     2021.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Hepato-Biliary-Pancreatic Sciences  

    Background: Clinical tumor staging is essential information for making a therapeutic decision in cancer. This study aimed to identify the optimal tumor classification system for predicting resectability and survival probability in perihilar cholangiocarcinoma. Methods: Patients who were treated for perihilar cholangiocarcinoma between 2009 and 2018 were enrolled. Local tumor extension was staged radiologically according to a diameter-based classification system in addition to the AJCC, Blumgart, and Bismuth systems. Survival and resectability were compared between T subgroups, and the discriminability of the four systems was assessed with Harrell’s concordance index (C-index). Results: Among 702 study patients, 559 (80.0%) underwent laparotomy, 489 (70.0%) of whom underwent resection. The resectability significantly decreased for more advanced tumors in all systems (P <.001); the AJCC system had the greatest discriminability for resectability (area under the curve 0.721). Overall survival at 5 years was 69.9% for AJCC cT1, 45.8% for cT2, 31.8% for cT3, and 15.3% for cT4 tumors (cT1 vs cT2; P =.002, cT2 vs cT3; P =.008 and cT3 vs cT4; P <.001). The AJCC system had the largest C-index of 0.627. Conclusions: The AJCC T system was the optimal classification system for predicting resectability and survival in perihilar cholangiocarcinoma.

    DOI: 10.1002/jhbp.1066

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  13. 増刊号 Stepごとに要点解説 標準術式アトラス最新版-特別付録Web動画 4.大腸 直腸癌-骨盤内臓全摘術

    小倉 淳司, 上原 圭, 村田 悠記, 三品 拓也, 伊神 剛, 水野 隆史, 山口 淳平, 宮田 一志, 尾上 俊介, 渡辺 伸元, 横山 幸浩, 江畑 智希

    臨床外科   Vol. 76 ( 11 ) page: 128 - 137   2021.10

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    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1407213500

    CiNii Research

  14. Efficacy of Extended Modification in Left Hemihepatectomy for Advanced Perihilar Cholangiocarcinoma: Comparison Between H12345'8'-B-MHV and H1234-B.

    Otsuka S, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Shimoyama Y, Igami T, Uehara K, Yokoyama Y, Nagino M, Ebata T

    Annals of surgery     2021.10

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    Language:English  

    DOI: 10.1097/SLA.0000000000005248

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  15. Ⅱ.Treatment for Recurrent Cholangiocarcinoma

    Watanabe N., Yokoyama Y., Igami T., Uehara K., Mizuno T., Yamaguchi J., Miyata K., Onoe S., Ogura A., Ebata T.

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   Vol. 48 ( 10 ) page: 1223 - 1226   2021.10

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    Authorship:Lead author   Language:Japanese   Publishing type:Part of collection (book)   Publisher:Gan to kagaku ryoho. Cancer &amp; chemotherapy  

    Scopus

  16. [Ⅱ.Treatment for Recurrent Cholangiocarcinoma]. Invited

    Watanabe N, Yokoyama Y, Igami T, Uehara K, Mizuno T, Yamaguchi J, Miyata K, Onoe S, Ogura A, Ebata T

    Gan to kagaku ryoho. Cancer & chemotherapy   Vol. 48 ( 10 ) page: 1223 - 1226   2021.10

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    Authorship:Lead author   Language:Japanese   Publishing type:Part of collection (book)  

    PubMed

  17. Adjuvant S-1 vs gemcitabine for node-positive perihilar cholangiocarcinoma: A propensity score-adjusted analysis

    Takahashi Daigoro, Mizuno Takashi, Yokoyama Yukihiro, Igami Tsuyoshi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Maeda Osamu, Ando Masahiko, Ebata Tomoki

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 28 ( 9 ) page: 716 - 726   2021.9

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    Language:Japanese   Publisher:Journal of Hepato-Biliary-Pancreatic Sciences  

    Background: The efficacy of adjuvant chemotherapy for biliary cancers remains controversial because of conflicting results from previous phase 3 studies that used different key drugs and enrolled patients with heterogeneous tumor sites and disease stages. Fluoropyrimidine seems more beneficial than gemcitabine (GEM) combination regimens in the adjuvant setting; however, data comparing the survival benefit between GEM- and fluoropyrimidine-based regimens are lacking. Methods: Patients who underwent resection for node-positive perihilar cholangiocarcinoma were included. The patients who underwent adjuvant chemotherapy were divided into the S-1 and GEM groups according to the regimen. The recurrence-free survival (RFS) and the overall survival (OS) were compared between the groups and adjusted with propensity scores generated from 14 potentially confounding clinicopathological factors. Results: In total, 186 patients (Surgery alone, n = 71; S-1, n = 60; GEM, n = 55) were included. The S-1 and GEM completion rates were 75% and 65%, respectively. Among the patients who underwent adjuvant therapy, the RFS was longer in the S-1 group patients than the GEM group patients (median, 24.4 months vs 14.9 months; P =.044) whereas the OS was not significantly different between the groups (median, 48.5 months vs 35.0 months; P =.324). After propensity score adjustment, the differences in RFS and OS between the groups were more evident (HR: 2.696, 95% CI: 1.739-4.180 P <.001; HR: 1.988, 95% CI: 1.221-3.238, P <.001, respectively). Conclusions: Compared with adjuvant GEM monotherapy, adjuvant S-1 monotherapy may improve survival in node-positive perihilar cholangiocarcinoma patients.

    DOI: 10.1002/jhbp.1005

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  18. Early Prediction of a Serious Postoperative Course in Perihilar Cholangiocarcinoma: Trajectory Analysis of the Comprehensive Complication Index. Reviewed International journal

    Kawakatsu S, Yamaguchi J, Mizuno T, Watanabe N, Onoe S, Igami T, Yokoyama Y, Uehara K, Nagino M, Matsuo K, Ebata T

    Annals of surgery     2021.8

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    Language:English  

    DOI: 10.1097/SLA.0000000000005162

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  19. Transanal lateral pelvic lymph node dissection

      Vol. 76 ( 5 ) page: 596 - 602   2021.5

  20. Hepatopancreatoduodenectomy with simultaneous resection of the portal vein and hepatic artery for locally advanced cholangiocarcinoma: Short- and long-term outcomes of superextended surgery Reviewed

    Nagino Masato, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 28 ( 4 ) page: 376 - 386   2021.4

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    Language:English   Publisher:Journal of Hepato-Biliary-Pancreatic Sciences  

    Background: Only a few authors have reported negative results for hepatopancreatoduodenectomy (HPD) with simultaneous resection of the portal vein and hepatic artery in a limited number of patients. The aim of the current study was to outline our experience with this superextended surgery and to discuss its clinical value. Methods: Medical records of consecutive patients who underwent resection of perihilar cholangiocarcinoma between 2007 and 2020 were retrospectively reviewed. Results: During the study interval, 650 patients with perihilar cholangiocarcinoma underwent resection. The superextended surgery was performed in only nine (1.4%) patients. Left or right trisectionectomy was primarily performed. For portal vein reconstruction, external iliac vein graft was required in seven patients. For hepatic artery reconstruction, rotating left gastric artery was often used. The median operative time was 870 minutes and blood loss was 2,598 mL. Postoperatively, pancreatic fistula and liver failure occurred in all patients, followed by intraabdominal abscess (n = 8), and bacteremia (n = 4). One patient died on day 86 due to multiple organ failure. Two patients survived for more than 7 years. Conclusions: HPD with simultaneous resection of the portal vein and hepatic artery is demanding but worth performing as the last option, with careful patient selection in experienced centers.

    DOI: 10.1002/jhbp.914

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  21. 特集 肝胆膵外科における再切除と再手術─最新の治療戦略 肝外胆管切除後の胆管癌再発に対する再切除

    渡辺 伸元, 江畑 智希

    手術   Vol. 75 ( 3 ) page: 297 - 302   2021.3

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    Authorship:Lead author   Publisher:金原出版  

    DOI: 10.18888/op.0000002097

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  22. Application of fluorescent cholangiography during single-incision laparoscopic cholecystectomy in the cystohepatic duct without preoperative diagnosis International journal

    Asai Yuichi, Igami Tsuyoshi, Ebata Tomoki, Yokoyama Yukihiro, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    ANZ JOURNAL OF SURGERY   Vol. 91 ( 3 ) page: 470 - 472   2021.3

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    Language:English   Publisher:ANZ Journal of Surgery  

    DOI: 10.1111/ans.16162

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  23. The influence of the preoperative thickness of the abdominal cavity on the gastrojejunal anatomic position and delayed gastric emptying after pancreatoduodenectomy Reviewed International journal

    Watanabe Nobuyuki, Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Nagino Masato

    HPB   Vol. 22 ( 12 ) page: 1695 - 1702   2020.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:HPB  

    DOI: 10.1016/j.hpb.2020.03.016

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  24. Preoperative biliary drainage: optimal method from a viewpoint of surgeon

    Ebata Tomoki, Mizuno Takashi, Onoe Shunsuke, Watanabe Nobuyuki, Igami Tsuyoshi, Yokoyama Yukihiro

    Tando   Vol. 34 ( 4 ) page: 781 - 789   2020.10

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    Language:Japanese   Publisher:Japan Biliary Association  

    <p>Hepatectomy for biliary tract cancer is well-known as a high-risk surgical procedure potentially yielding a high morbidity and mortality. Preoperative biliary drainage (PBD) has been routinely used in Japan, which totally conflicts to the indication in the West. However, recent studies demonstrated that PBD reduced the incidence of liver failure and mortality after right or more extended hepatectomy. Percutaneous transhepatic biliary drainage (PTBD) increased the incidences of catheter tract seeding and disseminated disease, thereby reducing postsurgical survival. This observation revises a PBD-strategy from percutaneous approach to endoscopic one, particularly in Japan. In addition, because preoperative cholangitis is highly associated with postoperative mortality, PBD should be chosen on the basis of the potential risk of procedure-related cholangitis. The first-line PBD is endoscopic naso-biliary drainage in Japan; endoscopic biliary stent or percutaneous biliary drainage in the overseas. Thus, the strategy of PBD still differ among regions or hospitals due to lack in scientific evidence.</p>

    DOI: 10.11210/tando.34.781

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  25. Mild Prognostic Impact of Postoperative Complications on Long-Term Survival of Perihilar Cholangiocarcinoma. Reviewed

    Kawakatsu S, Ebata T, Watanabe N, Onoe S, Yamaguchi J, Mizuno T, Igami T, Yokoyama Y, Matsuo K, Nagino M

    Annals of surgery     2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/SLA.0000000000004465

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  26. 特集 進行直腸癌のベストプラクティス II. 各論 5.局所再発直腸癌の再発部位を意識した治療戦略

    小倉 淳司, 上原 圭介, 相場 利貞, 江畑 智希, 横山 幸浩, 國料 俊男, 伊神 剛, 深谷 昌秀, 水野 隆史, 山口 淳平, 宮田 一志, 尾上 俊介, 渡辺 伸元, 梛野 正人

    外科   Vol. 82 ( 7 ) page: 742 - 748   2020.6

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    DOI: 10.15106/j_geka82_742

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  27. Simulation surgery based on patients' data for hepato-biliary-pancreatic surgery

      Vol. 75 ( 4 ) page: 466 - 475   2020.4

  28. A case of small in situ perihilar cholangiocarcinoma incidentally accompanied by benign bile duct stricture after open cholecystectomy Reviewed

    Maeda Takashi, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    SURGICAL CASE REPORTS   Vol. 5 ( 1 ) page: 177   2019.12

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  29. A case of duodenal hemorrhage due to arteriovenous malformation around a serous cystic neoplasm. Reviewed

    Tamura S, Yamamoto Y, Okamura Y, Sugiura T, Ito T, Ashida R, Ohgi K, Watanabe N, Sasaki K, Sugino T, Uesaka K

    Surgical case reports   Vol. 4 ( 1 ) page: 140   2018.12

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    DOI: 10.1186/s40792-018-0547-8

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  30. Clinical influence of preoperative factor XIII activity in patients undergoing pancreatoduodenectomy Reviewed International journal

    Watanabe Nobuyuki, Yokoyama Yukihiro, Ebata Tomoki, Sugawara Gen, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    HPB   Vol. 19 ( 11 ) page: 972 - 977   2017.11

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    DOI: 10.1016/j.hpb.2017.07.002

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  31. Anatomic features of independent right posterior portal vein variants: Implications for left hepatic trisectionectomy Reviewed International journal

    Watanabe Nobuyuki, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    SURGERY   Vol. 161 ( 2 ) page: 347 - 354   2017.2

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    Authorship:Lead author   Language:English   Publisher:Surgery (United States)  

    DOI: 10.1016/j.surg.2016.08.024

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KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. 消化器外科手術後感染性合併症を予防するプロバイオティクス製剤の開発

    Grant number:21K08731  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    横山 幸浩, 山口 淳平, 渡辺 伸元, 江畑 智希, 國料 俊男

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    Authorship:Coinvestigator(s) 

    われわれは先行研究で、周術期にプロバイオティクスを使用することにより、術後感染性合併症発生が抑制されることを確認してきた。われわれがプロバイオティクスとして使用したものはLactobacillus casei ShirotaおよびBifidobacterium breve Yakultであったが、これらがプロバイオティクス製剤として最善のものであるかについては不明である。ヒトの腸内には術後感染性合併症をより強く抑制する菌が存在する可能性がある。本研究では、高度侵襲外科手術後の合併症を最も強力に抑制する腸内細菌種を、無菌マウスにヒトの腸内細菌叢を移植したモデルを用いて探索することを目的にする。

  2. Novel diagnostic methods for invisible pancreas cancer

    Grant number:19K09168  2019.4 - 2022.3

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )