Updated on 2025/03/13

写真a

 
HYODO Ryota
 
Organization
Graduate School of Medicine Department of Fundamental Development for Advanced Low Invasive Diagnostic Imaging Endowed Chair Designated lecturer
Title
Designated lecturer

Degree 1

  1. 医学博士 ( 2015.3 ) 

Research Interests 1

  1. 4D flow MRI

Research Areas 1

  1. Life Science / Radiological sciences  / 4D Flow MRI

Research History 3

  1. Nagoya University Graduate Scgool of Medicine   Radiology   Assistant Professor

    2018.4

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    Country:Japan

  2. 市立四日市病院   放射線科   医員

    2015.4 - 2018.3

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    Country:Japan

  3. 名古屋大学医学部附属病院   放射線科   医員

    2012.4 - 2015.3

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    Country:Japan

Education 1

  1. Nagoya University   Graduate School of Medicine

    2012.4 - 2016.3

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    Country: Japan

Professional Memberships 3

  1. Japanese Society for Magnetic Resonance in Medicine

    2022.12

  2. 日本医学放射線学会

    2011.4

  3. 日本IVR学会

    2011.4

Awards 5

  1. 医学系研究科医学奨励賞 最優秀賞

    2024.2   東海国立大学機構  

    兵藤良太

  2. Certificate of Merit

    2022.5   European Sociery of Gastrointestinal and Abdominal Radiology  

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Masataka Sugiyama, Tomoki Ebata, Shinji Naganawa

  3. 第50回日本IVR学会総会 優秀症例報告賞

    2021.7   日本IVR学会   4D flow MRIが血行動態把握や治療評価に有用であったBudd-Chiari症候群の1例

    兵藤良太

  4. 第50回日本IVR学会総会 優秀症例報告賞

    2021.5   日本IVR学会   4D flow MRIが血行動態把握や治療評価に有用であったBudd-Chiari症候群の1例

    兵藤良太

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  5. 第50回日本IVR学会総会 優秀症例報告賞

    2021.5   日本IVR学会   4D flow MRIが血行動態把握や治療評価に有用であったBudd-Chiari症候群の1例

    兵藤良太

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

 

Papers 17

  1. Evaluation of 4D Flow MRI‐Derived Relative Residence Time as a Marker for Cirrhosis Associated Portal Vein Thrombosis

    Ryota Hyodo, Yasuo Takehara, Yoji Ishizu, Kazuki Nishida, Takashi Mizuno, Kazushige Ichikawa, Ryota Horiguchi, Nobuhiko Kurata, Yasuhiro Ogura, Shinya Yokoyama, Shinji Naganawa, Ning Jin, Yoshito Ichiba

    Journal of Magnetic Resonance Imaging   Vol. 60 ( 6 ) page: 2592 - 2601   2024.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jmri.29357

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  2. Four-dimensional Flow MRI Assessment of Portal Hemodynamics and Hepatic Regeneration after Portal Vein Embolization. International journal

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Ryota Horiguchi, Shoji Kawakatsu, Takashi Mizuno, Tomoki Ebata, Shinji Naganawa, Ning Jin, Yoshito Ichiba

    Radiology   Vol. 308 ( 3 ) page: e230709   2023.9

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    Background Percutaneous transhepatic portal vein (PV) embolization (PVE) is a standard preoperative procedure for advanced biliary cancer when the future liver remnant (FLR) is insufficient, yet the effect of this procedure on portal hemodynamics is still unclear. Purpose To assess whether four-dimensional (4D) MRI flowmetry can be used to estimate FLR volume and to identify the optimal time for this measurement. Materials and Methods This prospective single-center study enrolled consecutive adult patients with biliary cancer who underwent percutaneous transhepatic PVE for the right liver between June 2020 and November 2022. Portal hemodynamics were assessed using 4D flow MRI before PVE and within 1 day (0-day group) or 3-4 days (3-day group) after PVE. FLR volume was measured using CT before PVE and after PVE but before surgery. Blood flow changes were analyzed with the Wilcoxon signed rank test, and correlations with Spearman rank correlation. Results The 0-day group included 24 participants (median age, 72 years [IQR, 69-77 years]; 17 male participants), and the 3-day group included 13 participants (median age, 71 years [IQR, 68-78 years]; eight male participants). Both groups showed increased left PV (LPV) flow rate after PVE (0-day group: from median 3.72 mL/sec [IQR, 2.83-4.55 mL/sec] to 9.48 mL/sec [IQR, 8.12-10.7 mL/sec], P < .001; 3-day group: from median 3.65 mL/sec [IQR, 2.14-3.79 mL/sec] to 8.16 mL/sec [IQR, 6.82-8.98 mL/sec], P < .001). LPV flow change correlated with FLR volume change relative to the number of days from PVE to presurgery CT only in the 3-day group (ρ = 0.62, P = .02; 0-day group, P = .11). The output of the regression equation for estimating presurgery FLR volume correlated with CT-measured volume (ρ = 0.78; P = .002). Conclusion Four-dimensional flow MRI demonstrated increased blood flow in residual portal branches 3-4 days after PVE, offering insights for estimating presurgery FLR volume. Published under a CC BY 4.0 license. Supplemental material is available for this article. See also the editorial by Roldán-Alzate and Oechtering in this issue.

    DOI: 10.1148/radiol.230709

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  3. 4D Flow MRI in the portal venous system: imaging and analysis methods, and clinical applications. International journal Open Access

    Ryota Hyodo, Yasuo Takehara, Shinji Naganawa

    La Radiologia medica   Vol. 127 ( 11 ) page: 1181 - 1198   2022.11

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    Thus far, ultrasound, CT, and 2D cine phase-contrast MRI has been adopted to evaluate blood flow and vascular morphology in the portal venous system; however, all these techniques have some shortcomings, such as limited field of view and difficulty in accurately evaluating blood flow. A new imaging technique, namely 3D cine phase-contrast (4D Flow) MRI, can acquire blood flow data of the entire abdomen at once and in a time-resolved manner, allowing visual, quantitative, and comprehensive assessment of blood flow in the portal venous system. In addition, a retrospective blood flow analysis, i.e., "retrospective flowmetry," is possible. Although the development of 4D Flow MRI for the portal system has been delayed compared to that for the arterial system owing to the lower flow velocity of the portal venous system and the presence of respiratory artifacts, several useful reports have recently been published as the technology has advanced. In the first part of this narrative review article, technical considerations of image acquisition and analysis methods of 4D Flow MRI for the portal venous system and the validations of their results are described. In the second part, the current clinical application of 4D Flow MRI for the portal venous system is reviewed.

    DOI: 10.1007/s11547-022-01553-x

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  4. Pancreatic neuroendocrine tumors containing areas of iso- or hypoattenuation in dynamic contrast-enhanced computed tomography: Spectrum of imaging findings and pathological grading. International journal

    Ryota Hyodo, Kojiro Suzuki, Hiroshi Ogawa, Tomohiro Komada, Shinji Naganawa

    European journal of radiology   Vol. 84 ( 11 ) page: 2103 - 2109   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    PURPOSE: To evaluate dynamic contrast-enhanced computed tomography (CT) features of pancreatic neuroendocrine tumors (PNETs) containing areas of iso- or hypoattenuation and the relationship with pathological grading. MATERIALS AND METHODS: Between June 2006 and March 2014, 61 PNETs in 58 consecutive patients (29 male, 29 female; median-age 55 years), which were surgically diagnosed, underwent preoperative dynamic contrast-enhanced CT. PNETs were classified based on contrast enhancement patterns in the pancreatic phase: iso/hypo-PNETs were defined as tumors containing areas of iso- or hypoattenuation except for cystic components, and hyper-PNETs were tumors showing hyperattenuation over the whole area. CT findings and contrast-enhancement patterns of the tumors were evaluated retrospectively by two radiologists and compared with the pathological grading. RESULTS: Iso/hypo-PNETs comprised 26 tumors, and hyper-PNETs comprised 35 tumors. Not only hyper-PNETs but also most iso/hypo-PNETs showed peak enhancement in the pancreatic phase and a washout from the portal venous phase to the delayed phase. Iso/hypo-PNETs showed larger tumor size than the hyper-PNETs (mean, 3.7 cm vs. 1.6 cm; P<0.001), and were significantly correlated with unclear tumor margins (n=4 vs. n=0; P=0.029), the existence of cystic components (n=10 vs. n=3; P=0.006), intratumoral blood vessels in the early arterial phase (n=13 vs. n=3; P<0.001), and a smooth rim enhancement in the delayed phase (n=12 vs. n=6; P=0.019). Iso/hypo-PNETs also showed significantly higher pathological grading (WHO 2010 classification; iso/hypo, G1=14, G2=11, G3=1; hyper, G1=34, G2=1; P<0.001). CONCLUSION: PNETs containing iso/hypo-areas showed a rapid enhancement pattern as well as hyper-PNETs, various radiological features and higher malignant potential.

    DOI: 10.1016/j.ejrad.2015.08.014

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  5. Editorial for "Comparative Performance of 2018 LI-RADS versus Modified LIRADS (mLI-RADS): An Individual Participant Data Meta-Analysis". International journal

    Yasuo Takehara, Ryota Hyodo

    Journal of magnetic resonance imaging : JMRI   Vol. 60 ( 3 ) page: 1092 - 1093   2024.9

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  6. The immediate post-operative impact of infrarenal aortic endografts on renal arterial flow dynamics: Insights from four-dimensional flow magnetic resonance imaging analysis

    Sugimoto, M; Horiguchi, R; Ikeda, S; Kawai, Y; Niimi, K; Hyodo, R; Banno, H

    VASCULAR     page: 17085381241277651   2024.8

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    Language:English   Publisher:Vascular  

    Objectives: This study aims to quantify changes in renal blood flow before and after endovascular aneurysm repair (EVAR) using four-dimensional (4D) flow magnetic resonance imaging (MRI) and evaluate its correlation with renal impairment. Methods: In this retrospective analysis, 18 patients underwent elective EVAR for infrarenal fusiform abdominal aortic aneurysms using Excluder or Endurant endografts. 4D flow MRI scans were conducted before and 1–4 days after EVAR. Hemodynamics were quantified at the suprarenal aorta (SupAo), bilateral renal arteries (RRA and LRA), and infrarenal aorta (InfAo). Cardiac phase-resolved blood flow values (BFVs), relative flow distribution (RFD), and flow change rates (FCRs) were assessed. Estimated glomerular filtration rate (eGFR) was measured pre- and postoperatively. Results: A total of 16 patients were analyzed after excluding two outliers. Pre-EVAR BFVs were 23.1 ± 8.3, 3.7 ± 1.3, 3.4 ± 1.2, and 15.1 ± 5.9 mL/cycle, while post-EVAR BFVs were 20.9 ± 6.9, 3.8 ± 1.1, 3.2 ± 0.9, and 12.1 ± 4.3 mL/cycle in SupAo, RRA, LRA, and InfAo, respectively. Comparing Excluder (N = 8) and Endurant (N = 8), the total renal FCR was 121.8% [106.6–144.7] versus 101.3% [63.8–121.8] (p = 0.110), suggesting a potential improvement in renal blood flow with the Excluder, although not statistically significant. A significant correlation was found between the total renal FCR and the relative eGFR at 6 months (Spearman correlation coefficient, 0.789; p < 0.001). Conclusions: The endografts, particularly the Excluder, showed potential in improving renal artery blood flow in some patients. The significant correlation between the total renal FCR and the relative eGFR at 6 months suggests that acute hemodynamic alterations induced by EVAR may impact post-operative renal function. Further research is needed to confirm these findings and assess their clinical implications.

    DOI: 10.1177/17085381241277651

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  7. Postendovascular Aneurysmal Repair Increase in Local Energy Loss for Fusiform Abdominal Aortic Aneurysm: Assessments With 4D flow MRI. International journal Open Access

    Ryota Horiguchi, Yasuo Takehara, Masataka Sugiyama, Ryota Hyodo, Tomohiro Komada, Masaya Matsushima, Shinji Naganawa, Takashi Mizuno, Yasuo Sakurai, Masayuki Sugimoto, Hiroshi Banno, Kimihiro Komori, Keiichi Itatani

    Journal of magnetic resonance imaging : JMRI   Vol. 57 ( 4 ) page: 1199 - 1211   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    BACKGROUND: Although endovascular aneurysmal repair (EVAR) is a preferred treatment for abdominal aortic aneurysm (AAA) owing to its low invasiveness, its impact on the local hemodynamics has not been fully assessed. PURPOSE: To elucidate how EVAR affects the local hemodynamics in terms of energy loss (EL). STUDY TYPE: Prospective single-arm study. FIELD STRENGTH/SEQUENCE: A 3.0 T/4D flow MRI using a phase-contrast three-dimensional cine-gradient-echo sequence. POPULATION: A total of 13 consecutive patients (median [interquartile range] age: 77.0 [73.0, 78.8] years, 11 male) scheduled for EVAR as an initial treatment for fusiform AAA. ASSESSMENT: 4D flow MRI covering the abdominal aorta and bilateral common iliac arteries and the corresponding stent-graft (SG) lumen was performed before and after EVAR. Plasma brain natriuretic peptide (BNP) was measured within 1 week before and 1 month after EVAR. The hemodynamic data, including mean velocity and the local EL, were compared pre-/post-EVAR. EL was correlated with AAA neck angle and with BNP. Patients were subdivided into deformed (N = 5) and undeformed SG subgroups (N = 8) and pre-/post-EVAR BNP compared in each. STATISTICS: Parametric or nonparametric methods. Spearman's rank correlation coefficients (r). The interobserver/intraobserver variabilities with Bland-Altman plots. A P value < 0.05 is considered significant. RESULTS: The mean velocity (cm/sec) at the AAA was five times greater after EVAR: 4.79 ± 0.32 vs. 0.91 ± 0.02. The total EL (mW) increased by 1.7 times after EVAR: 0.487 (0.420, 0.706) vs. 0.292 (0.192, 0.420). The total EL was proportional to the AAA neck angle pre-EVAR (r = 0.691) and post-EVAR (r = 0.718). BNP (pg/mL) was proportional to the total EL post-EVAR (r = 0.773). In the deformed SG group, EL (0.349 [0.261, 0.416]) increased 2.4-fold to 0.848 (0.597, 1.13), and the BNP 90.3 (53.6, 105) to 100 (67.2, 123) post-EVAR. CONCLUSION: The local EL showed a 1.7-fold increase after EVAR. The larger increase in the EL in the deformed SG group might be a potential concern for frail patients. EVIDENCE LEVEL: 1 TECHNICAL EFFICACY: Stage 2.

    DOI: 10.1002/jmri.28359

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  8. "Speckled Enhancement" on Gd-EOB-DTPA Enhanced MR Imaging of Primary Hepatic Mucosa-associated Lymphoid Tissue Lymphoma. Open Access

    Ryota Hyodo, Yasuo Takehara, Ayumi Nishida, Masaya Matsushima, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 22 ( 3 ) page: 273 - 281   2023

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Magnetic Resonance in Medicine  

    PURPOSE: To elucidate MRI features of primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma, particularly, the "speckled enhancement" on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI. METHODS: The institutional review board approved this retrospective observational study and waived informed consent. Using our picture archiving and communication systems and electronic medical records, five patients histopathologically diagnosed as hepatic MALT lymphoma and clinically confirmed as primary lesions who had undergone dynamic contrast-enhanced (DCE)-CT and DCE-MRI with Gd-EOB-DTPA were identified from September 2009 to December 2020. Two radiologists assessed their CT and MRI data in consensus with a pathologist's advice. RESULTS: Overall, five lesions in five patients were included in this study. Precontrast CT showed hypoattenuation in all lesions. In the arterial phase of DCE-CT, four lesions (80%) showed hyperattenuation, whereas all lesions showed iso- to hypoattenuation in the delayed phase. A vessel penetration sign was also observed in all lesions. On MRI, all lesions showed hypointensity on T1-weighted images, hyperintensity on T2-weighted images, and restricted diffusion on diffusion-weighted images. Both DCE-CT and DCE-MRI with Gd-EOB-DTPA showed similar enhancement patterns, except for the hepatocyte phase. Notably, however, four out of five lesions showed characteristic "speckled enhancement" that refers to punctate positive enhancements within the low signal lesions on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI pathologically confirmed to be hepatocyte clusters that remained in the tumor. CONCLUSION: Primary hepatic MALT lymphomas were characterized by arterial phase enhancement, restricted diffusion, vessel penetration sign, and more specifically "speckled enhancement" in the hepatobiliary phase of DCE-MRI with Gd-EOB-DTPA.

    DOI: 10.2463/mrms.mp.2021-0069

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  9. Assessing the Complicated Venous Hemodynamics and Therapeutic Outcomes of Budd-Chiari Syndrome with Respiratory-gated 4D Flow MR Imaging During the Expiratory and Inspiratory Phases. Open Access

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Shinya Yokoyama, Yoji Ishizu, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 22 ( 1 ) page: 1 - 6   2023

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Magnetic Resonance in Medicine  

    A man in his 50s with Budd-Chiari syndrome diagnosed with the suprahepatic inferior vena cava (IVC) obstruction on CT was assessed using 4D Flow MRI before and after balloon angioplasty. 4D Flow MRI acquired in two respiratory phases, depicted complex hemodynamic and respiratory variability, and a jet stream at the narrowed channel of the membranous IVC. Post-interventional 4D Flow MRI showed that the IVC blood flow increased with corrected flow directions in the infrarenal IVC.

    DOI: 10.2463/mrms.ici.2021-0110

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  10. Embolization using patient-specific vascular models created by a 3D printer for difficult cases: a report of two cases.

    Tomohiro Komada, Takeshi Kamomae, Masaya Matsushima, Ryota Hyodo, Shinji Naganawa

    Nagoya journal of medical science   Vol. 84 ( 2 ) page: 477 - 483   2022.5

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    With the widespread use of three-dimensional printers, organ models created by these printers are now being used in the medical field for preoperative planning of surgeries. In this article, we report two cases in which embolization was expected to be difficult, and the three-dimensional printer-based vascular modeling was helpful in planning the surgery. The first case involved an aneurysm of the splenic artery. We attempted to embolize the aneurysm but were unable to advance the catheter into the distal artery and discontinued the procedure. The second case was a perianal varicose vein, which was initially treated with percutaneous transhepatic obliteration but was recanalized and required embolization. However, we expected difficulty in selecting the inferior mesenteric vein. In both cases, the vascular models were created using a 3D printer from the patients' computed tomography images. Preoperative planning, including treatment simulation, was based on these models. The time required to print a three-dimensional vascular model was approximately 12 hours at a cost of less than $10 each. Patient-specific vascular models using a three-dimensional printer can be a simple and inexpensive tool that can increase the success of embolization in difficult cases.

    DOI: 10.18999/nagjms.84.2.477

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  11. Time-resolved 3D cine phase-contrast magnetic resonance imaging (4D-flow MRI) can quantitatively assess portosystemic shunt severity and confirm normalization of portal flow after embolization of large portosystemic shunts. International journal

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yoji Ishizu, Masataka Sugiyama, Shinji Naganawa

    Hepatology research : the official journal of the Japan Society of Hepatology   Vol. 51 ( 3 ) page: 343 - 349   2021.3

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    Diagnosis and severity assessments of portosystemic shunts (PSSs) are important because the pathology sometimes results in severe hepatic encephalopathy, which can be treated almost completely by shunt embolization. At present, morphological assessment of PSS is performed mainly by computed tomography, and ultrasound is used for blood flow assessment. In two cases of PSS-related hepatic encephalopathy, we used time-resolved 3D cine phase-contrast (4D-flow) magnetic resonance imaging (MRI) to assess blood flow before and after shunt embolization. Before the intervention, blood flow in the main trunk of the superior mesenteric vein was mostly hepatofugal. However, post-interventional 4D-flow MRI revealed hepatopetal superior mesenteric vein flow with significantly increased portal vein blood flow. 4D-flow MRI is an ideal adjunct to Doppler ultrasonography, allowing for objective and visual assessment of morphology and blood flow of the portal venous system, including PSSs, and is useful in determining the indications for, and outcome of, PSS embolization.

    DOI: 10.1111/hepr.13616

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  12. Portal Vein Stenosis Following Liver Transplantation Hemodynamically Assessed with 4D-flow MRI before and after Portal Vein Stenting. Open Access

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yasuhiro Ogura, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 3 ) page: 231 - 235   2021

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Magnetic Resonance in Medicine  

    We present a case of a patient who underwent portal vein (PV) stenting for PV stenosis after a living-donor liver transplantation. A pretreatment 3D cine phase-contrast (4D-flow) MRI showed decreased, though hepatopetal, blood flow in the PV. After stenting, 4D-flow MRI confirmed an improvement in PV flow, with a more homogeneous flow distribution to each hepatic segment. 4D-flow MRI are valuable for understanding the hemodynamics of this area, planning for treatments, and evaluating the outcome of the interventions.

    DOI: 10.2463/mrms.ici.2020-0057

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  13. 画像診断と病理 食道平滑筋腫

    兵藤 良太, 岩野 信吾, 長縄 慎二, 宮田 一志, 島田 聡子

    画像診断   Vol. 39 ( 7 ) page: 662 - 663   2019.5

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    DOI: 10.15105/gz.0000001162

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  14. Assessment of percutaneous transhepatic portal vein embolization with portal vein stenting for perihilar cholangiocarcinoma with severe portal vein stenosis.

    Ryota Hyodo, Kojiro Suzuki, Tomoki Ebata, Tomohiro Komada, Yoshine Mori, Yukihiro Yokoyama, Tsuyoshi Igami, Gen Sugawara, Shinji Naganawa, Masato Nagino

    Journal of hepato-biliary-pancreatic sciences   Vol. 22 ( 4 ) page: 310 - 315   2015.4

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    BACKGROUND: The aim of the present study was to assess the clinical efficiency of portal vein (PV) stenting when performed with preoperative percutaneous transhepatic portal vein embolization (PTPVE) in patients with severe PV stenosis due to tumor invasion. METHODS: Between 2007 and 2013, four consecutive patients (one male, three females; mean age, 52 years; age range, 25-73 years) with perihilar cholangiocarcinoma and PV stenosis underwent PTPVE and PV stenting. Patients were analyzed with regard to the procedure, hypertrophy of the future remnant liver (FRL), and plasma clearance rate of indocyanine green by the FRL (ICGK-F). Further, the %FRL volume increase in PTPVE was compared between the stenting group and the usual PTPVE group who have perihilar cholangiocarcinomas without PV stenosis. RESULTS: Preoperative PTPVE with PV stenting was successfully performed and portal flow to the FRL improved after stenting in all four patients. The %FRL volume increase was 18-60% (mean, 34%) in the stenting group and was 12-51% (mean, 21%) in the usual PTPVE group. The ICGK-F value after PTPVE exceeded 0.05 in all four patients. All patients achieved R0 resection. CONCLUSIONS: Preoperative PTPVE with PV stenting appears to be feasible in cases of severe PV tumor invasion and stenosis. This procedure may allow a broader indication for surgery.

    DOI: 10.1002/jhbp.200

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  15. SOLITARY FIBROUS TUMORS IN THE EXTREMITIES: IMAGING FINDINGS FOR SIX PATIENTS Reviewed

    Ryota Hyodo, Tomohiro Komada, Akira Takada, Hisashi Kawai, Shinji Ito, Yoshihiro Nishida, Shinji Naganawa

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 77 ( 1-2 ) page: 167 - 178   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:NAGOYA UNIV, SCH MED  

    The purpose of this study was to describe the magnetic resonance imaging (MRI) and computed tomography (CT) findings for solitary fibrous tumors (SFTs) in the extremities in correlation with histopathological findings. Between 2006 and 2013, 6 consecutive patients with SFT in an extremity were studied with MRI (6 patients) and CT (4 patients). Diffusion-weighted images were also performed in 3 patients and dynamic contrast-enhanced CT in 2 patients. All 6 tumors were diagnosed after surgical excision, and the pre-surgical imaging findings were correlated with the histopathological findings. As a result, all 6 patients were female, and each had a clearly palpable, well-circumscribed, round or oval mass adjacent to fascia in an extremity, of less than 10 cm maximum diameter in 5 patients. On MRI, the tumors were iso-intense with muscle on T1-weighted image, and appeared heterogeneous and high-intensity on T2-weighted image. After injection of a contrast agent, the tumors demonstrated strong enhancement. A vascular pedicle was detected in 4 patients with tumors having a maximum diameter more than 5 cm. Diffusion-weighted images demonstrated high signal intensities, and apparent diffusion coefficient values were iso to high compared to muscle (from 1.41-2.10x10(-3) mm(2)/s). All the tumors were benign histopathologically and clinically. In 1 patient, the imaging appearance revealed underlying histopathological components, including fibrous-rich, cellular-rich, and myxoid change areas. In conclusion, a SFT in an extremity comprises a well-circumscribed mass adjacent to fascia having a fibrous-dominant area, strong contrast enhancement, and a vascular pedicle.

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  16. Solitary fibrous tumors in the extremities: imaging findings for six patients.

    Ryota Hyodo, Tomohiro Komada, Akira Takada, Hisashi Kawai, Shinji Ito, Yoshihiro Nishida, Shinji Naganawa

    Nagoya journal of medical science   Vol. 77 ( 1-2 ) page: 167 - 78   2015.2

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    The purpose of this study was to describe the magnetic resonance imaging (MRI) and computed tomography (CT) findings for solitary fibrous tumors (SFTs) in the extremities in correlation with histopathological findings. Between 2006 and 2013, 6 consecutive patients with SFT in an extremity were studied with MRI (6 patients) and CT (4 patients). Diffusion-weighted images were also performed in 3 patients and dynamic contrast-enhanced CT in 2 patients. All 6 tumors were diagnosed after surgical excision, and the pre-surgical imaging findings were correlated with the histopathological findings. As a result, all 6 patients were female, and each had a clearly palpable, well-circumscribed, round or oval mass adjacent to fascia in an extremity, of less than 10 cm maximum diameter in 5 patients. On MRI, the tumors were iso-intense with muscle on T1-weighted image, and appeared heterogeneous and high-intensity on T2-weighted image. After injection of a contrast agent, the tumors demonstrated strong enhancement. A vascular pedicle was detected in 4 patients with tumors having a maximum diameter more than 5 cm. Diffusion-weighted images demonstrated high signal intensities, and apparent diffusion coefficient values were iso to high compared to muscle (from 1.41-2.10×10(-3) mm(2)/s). All the tumors were benign histopathologically and clinically. In 1 patient, the imaging appearance revealed underlying histopathological components, including fibrous-rich, cellular-rich, and myxoid change areas. In conclusion, a SFT in an extremity comprises a well-circumscribed mass adjacent to fascia having a fibrous-dominant area, strong contrast enhancement, and a vascular pedicle.

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  17. Solitary fibrous tumors in the extremities: Imaging findings for six patients

    Hyodo R., Komada T., Takada A., Kawai H., Ito S., Nishida Y., Naganawa S.

    Nagoya Journal of Medical Science   Vol. 77 ( 1-2 ) page: 167 - 178   2015

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    Language:Japanese   Publisher:Nagoya Journal of Medical Science  

    The purpose of this study was to describe the magnetic resonance imaging (MRI) and computed tomography (CT) findings for solitary fibrous tumors (SFTs) in the extremities in correlation with histopathological findings. Between 2006 and 2013, 6 consecutive patients with SFT in an extremity were studied with MRI (6 patients) and CT (4 patients). Diffusion-weighted images were also performed in 3 patients and dynamic contrast-enhanced CT in 2 patients. All 6 tumors were diagnosed after surgical excision, and the pre-surgical imaging findings were correlated with the histopathological findings. As a result, all 6 patients were female, and each had a clearly palpable, well-circumscribed, round or oval mass adjacent to fascia in an extremity, of less than 10 cm maximum diameter in 5 patients. On MRI, the tumors were iso-intense with muscle on T1-weighted image, and appeared heterogeneous and high-intensity on T2-weighted image. After injection of a contrast agent, the tumors demonstrated strong enhancement. A vascular pedicle was detected in 4 patients with tumors having a maximum diameter more than 5 cm. Diffusion-weighted images demonstrated high signal intensities, and apparent diffusion coefficient values were iso to high compared to muscle (from 1.41-2.10×10-3 mm2/s). All the tumors were benign histopathologically and clinically. In 1 patient, the imaging appearance revealed underlying histopathological components, including fibrous-rich, cellular-rich, and myxoid change areas. In conclusion, a SFT in an extremity comprises a well-circumscribed mass adjacent to fascia having a fibrous-dominant area, strong contrast enhancement, and a vascular pedicle.

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MISC 1

  1. ロボット支援前立腺全摘除術後の難治性乳び腹水に対してリンパ管塞栓術が奏功した一例

    兵藤 良太, 山田 恵一郎, 堀口 瞭太, 伊藤 準, 松島 正哉, 駒田 智大, 大脇 貴之, 竹原 康雄, 長縄 慎二

    日本インターベンショナルラジオロジー学会雑誌   Vol. 35 ( Suppl. ) page: 290 - 290   2020.8

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    Language:Japanese   Publisher:(一社)日本インターベンショナルラジオロジー学会  

Presentations 25

  1. 肝硬変と門脈圧亢進症 Invited

    兵藤良太

    第51回日本磁気共鳴医学会大会  2023.9.22 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  2. 門脈領域の4D flow MRI Invited

    兵藤良太

    第50回日本磁気共鳴医学会大会  2022.9.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  3. Portal blood flow in the remnant portal branches is increased after percutaneous transhepatic portal vein embolization (PTPVE) for biliary tract cancer: An analysis with 4D flow MRI

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Masataka Sugiyama, Tomoki Ebata, Shinji Naganawa

    ESGAR 2022 

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    Event date: 2022.5 - 2022.6

    Language:English   Presentation type:Poster presentation  

  4. Fully Automated Segmentation Using Artificial Intelligence for Post-Analysis in 4D Flow MRI of the Portal Vein

    Ryota Hyodo, Rintaro Ito, Ryota Horiguchi, Takashi Mizuno, Kazushige Ichikawa, Mami Iima, Shinji Naganawa

    Society of Magnetic Resonance Angiography 2024  2024.11.13 

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    Event date: 2024.11

    Language:English   Presentation type:Oral presentation (general)  

  5. 4D Flow MRI: 介入治療術前後(大血管・門脈) Invited

    兵藤良太

    第52回日本磁気共鳴医学会大会  2024.9.20 

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    Event date: 2024.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  6. 門脈血流解析の進化:4D Flow MRIを用いた新たなアプローチ Invited

    兵藤良太

    第52回日本磁気共鳴医学会大会  2024.9.22 

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    Event date: 2024.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  7. Body Imaging: 4D Flow MRI in the Portal Vein Area Invited

    Ryota Hyodo

    2024.9.21 

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    Event date: 2024.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  8. Reproducibility of 4D Flow-Derived Hemodynamic Parameters in the Portal Venous Region Using Non-Contrast 4D Flow MRI

    Ryota Hyodo, Yasuo Takehara, Masataka Sugiyama, Daiki Tamashiro, Takashi Mizuno, Kazushige Ichikawa, Nobuhiko Kurata, Yasuhiro Ogura, Shinji Naganawa

    European Society of Gastrointestinal and Abdominal Radiology (ESGAR) 2024 

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    Event date: 2024.5

    Language:English   Presentation type:Poster presentation  

  9. Four-dimensional Flow MRI Assessment of Portal Hemodynamics and Hepatic Regeneration after Portal Vein Embolization Invited

    Ryota Hyodo

    2024.5.8 

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    Event date: 2024.5

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  10. Hemodynamic changes in liver transplant donors after surgery: analysis with 4D flow MRI

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yasuhiro Ogura, Shinji Naganawa

    2023.10 

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    Event date: 2023.10

    Language:English   Presentation type:Poster presentation  

  11. Embolization of the large portosystemic shunt increases portal blood flow and improves liver function: a 4D Flow MRI analysis

    Ryota Hyodo, Yasuo Takehara, Yoji Ishizu, Takashi Mizuno, Kazushige Ichikawa, Shinji Naganawa

    Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2023  2023.9 

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    Event date: 2023.9

    Language:English   Presentation type:Poster presentation  

  12. Patients with liver cirrhosis have more stagnant portal venous blood flow compared to non-cirrhotic subjects: analysis using 4D flow MRI

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yoji Ishizu, Yasuhiro Ogura, Shinji Naganawa

    International Society for Magnetic Resonance in Medicine (ISMRM) 2023  2023.6.7 

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    Event date: 2023.6

    Language:English   Presentation type:Poster presentation  

  13. Hemodynamic changes in liver transplant donors after surgery: analysis with 4D flow MRI

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yasuhiro Ogura, Shinji Naganawa

    2023.3 

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    Event date: 2023.3

    Language:English   Presentation type:Poster presentation  

  14. 小児に対し部分脾動脈塞栓術を施行した一例

    小木曽由梨, 長坂憲, 兵藤良太, 松島正哉, 駒田智大, 岩野信吾, 長縄慎二

    第71回中部・第72回関西IVR研究会  2023.2.4 

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    Event date: 2023.2

    Language:Japanese   Presentation type:Oral presentation (general)  

  15. CV リザーバー抜去困難に対しガイディングシースでカテーテルの固着を剥離し、 抜去できた一例

    松島正哉, 佐藤雄基, 小木曾由梨, 長坂 憲, 兵藤良太, 駒田智大, 岩野信吾, 長縄慎二, 下方智也

    第70回中部IVR研究会  2022.7.9 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  16. A case of a large portosystemic shunt in which 4D flow MRI was useful for hemodynamic evaluation

    Ryota Hyodo, Yasuo Takehara, Tomohiro Komada, Masaya Matsushima, Takashi Mizuno, Kazushige Ichikawa, Yoshiaki Sugiyama, Yoji Ishizu, Yuki Sato, Yuri Ogiso, Ken Nagasaka, Masataka Sugiyama, Shinji Naganawa

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    Event date: 2022.6

    Language:English   Presentation type:Poster presentation  

  17. COVID-19 肺炎加療中に生じた胆嚢出血に対して塞栓術を施行した 1 例

    小木曾由梨, 長坂 憲, 佐藤雄基, 兵藤良太, 松島正哉, 駒田智大, 岩野信吾, 長縄慎二

    第69回中部IVR研究会  2022.2.19 

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    Event date: 2022.2

    Language:Japanese   Presentation type:Oral presentation (general)  

  18. EDコイルが有用であった膵癌術前化学放射線療法中の消化管出血の症例 Invited

    兵藤良太, 駒田智大, 佐藤雄基, 小木曾由梨, 長坂憲, 松島正哉

    IVR-WEB講演会 ~この症例同治療する?~  2021.12.15 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  19. 左後腹悪性リンパ腫に合併した後腹膜血腫、仮性動脈瘤に対して塞栓術を施行した1例

    佐藤雄基, 松島正哉, 小木曾由梨, 長坂 憲, 兵藤良太, 駒田智大, 岩野信吾, 長縄慎二, 葉名尻良, 武内 大, 堀口瞭太

    第68回中部IVR研究会  2021.7.3 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  20. A case of Budd-Chiari syndrome in which 4D flow MRI was useful in assessing hemodynamics and therapy

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    Event date: 2021.5

    Language:Japanese   Presentation type:Poster presentation  

  21. ロボット支援前立腺全摘除術後の難治性乳び腹水に対して リンパ管塞栓術が奏功した一例

    兵藤良太, 山田恵一郎, 堀口瞭太, 伊藤準, 松島正哉, 駒田智大, 大脇貴之, 竹原康雄, 長縄慎二

    第49回日本IVR学会総会 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Poster presentation  

  22. 肝内門脈静脈短絡に対し塞栓術を施行した2例

    松島正哉, 駒田智大, 山田恵一郎, 堀口瞭太, 伊藤 準, 兵藤良太, 岩野信吾, 長縄慎二, 石津洋二, 田中 卓, 馬越弘泰

    第66回中部IVR研究会  2019.7.13 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  23. 感染契機の肺動脈仮性動脈瘤からの喀血に対して塞栓術を施行した1例

    山田恵一郎, 兵藤良太, 堀口瞭太, 伊藤準, 松島正哉, 駒田智大, 長縄慎二, 進藤有一郎, 長坂憲

    第49回日本IVR学会総会 

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    Event date: 2019.5 - 2019.6

    Language:Japanese   Presentation type:Poster presentation  

  24. Pancreatic neuroendocrine tumors: Assessment of dynamic contrast-enhanced CT features and the pathological grading

    Ryota Hyodo, Kojiro Suzuki, Hiroshi Ogawa, Tomohiro Komada, Shinji Naganawa

    The 74rd Annual meeting of the Japan Radiological Society  2015.4.19 

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    Event date: 2015.4

    Language:Japanese   Presentation type:Oral presentation (general)  

  25. 門脈系の4D Flow MRI Invited

    兵藤良太

    第23回放射線研究セミナー  2022.4.2 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. 進行胆道癌術前の経皮経肝門脈塞栓術による肝血流・機能変化:4D-Flow MRIとCFD解析

    Grant number:23K14917  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  若手研究

    兵藤 良太

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    進行胆道癌の術前経皮経肝門脈塞栓術の前後に3次元シネ位相コントラストMRI(4D-Flow MRI)を撮像することで、門脈の流速、流量や壁剪断応力などの血流パラメータを取得できる。また術前CTのデータからコンピューターシミュレーションも行い、仮想経皮経肝門脈塞栓術前後の門脈の血流パラメータを取得する。これらの術前後の変化が残存予定肝葉の体積の増大や機能の上昇とどのように関連するかを検討し、経皮経肝門脈塞栓術の肝再生への影響を評価する。
    年間で、門脈領域の4D Flow MRIの57症例を収集し解析を行った。具体的には消化器外科とともに門脈塞栓術前後の症例や胆道癌術後症例、移植外科とともに生体肝移植ドナーやレシピエント、消化器内科とともに肝硬変・門脈血栓・カテーテル介入前後の症例を収集した。
    このうち、胆道癌術前の門脈塞栓術に関しては、その前後の血流変化と残存予定肝実質の体積増大の関連を解析し、門脈右枝塞栓術前と塞栓3-4日後の門脈左枝の流量の変化が、その後の肝体積増大の予測に役立つことを示し、これを論文化した。この論文内では4D Flow MRIからWall shear Stress(血流の血管壁への摩擦を示す値)を算出しており、その塞栓術前後の変化を検討している。このWall Shear Stressはいままで基礎研究において肝再生カスケードのトリガーになると報告されてきたがin vivoでは評価不可能であった。まだ空間分解能が低いものの、本研究ではこのWall Shear Stressの値を門脈領域においてin vivoで初めて報告した。
    また、門脈血栓がある症例とない症例を集めて、多変量解析で評価したところ、門脈血栓の存在している症例は4D Flow MRIから得られる血流ベクトル由来血流パラメーターであるRelative Residence Timeが有意に高く、また血小板数が有意に低いという結果を得た。このRelative Residence Timeは血流ベクトル由来パラメーターであるWall Shear StressとOscillatory Shear Index(Wall Shear Stressの時間変動を示す)から計算され、血流のよどみを示すとされており、血栓形成のウィルヒョウの3徴の1つを表すと考えられている。これについても論文化した。
    症例集積が終了し、すでにRadiology誌(2023;308:e230709)に「Four-dimensional Flow MRI Assessment of Portal Hemodynamics and Hepatic Regeneration after Portal Vein Embolization」という題名で論文が掲載されたため。
    報告はPTPEにおいても肝右葉の塞栓のみの症例であり、左3区域(肝左葉と前区域)でも同様の結果が出るかどうかの検討、および論文中で提案したPTPE後の肝体積増大の推定式が実際に有用かどうかの評価を行っていく。

  2. Development of Rupture-Risk-Prediction System for Aortic Aneurysm Using Fluid&#8211;Structure Interaction Analysis.

    Grant number:21H02868  2021.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Takehara Yasuo

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    Authorship:Coinvestigator(s) 

    The abdominal aorta undergoes arteriosclerosis with aging, resulting in elongated and curved flow paths that induce local turbulence and a decrease in local wall shear stress (WSS). This promotes the worsening of atherosclerosis and further wall weakening through coagulation-fibrinolysis and immune systems, leading to local wall bulging and further turbulence. This vicious cycle creates abdominal aortic aneurysms. We developed an in-silico model using fluid-structure interaction (FSI) analysis to iteratively reproduce this vicious cycle. This model was validated against in-vivo results from contrast-enhanced MR angiography and 4D Flow MRI, and in-vitro results from phantom experiments, in 12 actual AAA patients. The prototype model showed that the non-dilated abdominal aorta remodels and gradually approximates the shape of an actual AAA.

  3. Small-for-size syndrome and portal vein wall shear stress in living donor liver transplantation: 4D Flow and CFD analysis

    Grant number:19K17165  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Hyodo Ryota

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    By imaging 4D flow MRI of the portal venous system in liver transplantation (before and after donor and recipient surgery), gastroenterology (before and after percutaneous transcatheter embolization for hepatic encephalopathy), and gastroenterology surgery (before and after percutaneous transhepatic portal vein embolization, etc.), we can obtain portal vein blood flow and blood flow parameters that can be measured with the 4D flow in normal and cirrhotic livers. Based on these changes, we examined whether the mechanism of liver regeneration shown in in-virto can be applied in-vivo, and also examined the indications and therapeutic effects of treatment for each disease. As a result, we were able to confirm in-vivo the liver regeneration after an increase in wall shear stress as shown in basic research, and were also able to visualize the therapeutic effects of other treatments based on the changes in blood flow after treatment.