Updated on 2024/03/26

写真a

 
YASUI Takeshi
 
Organization
Graduate School of Pharmaceutical Sciences Department of Basic Medicinal Sciences Organic Chemistry Assistant Professor
Graduate School
Graduate School of Pharmaceutical Sciences
Undergraduate School
School of Engineering Chemistry and Biotechnology
Title
Assistant Professor

Degree 1

  1. 博士(工学) ( 2013.3   名古屋大学 ) 

Research Areas 2

  1. Life Science / Pharmaceutical chemistry and drug development sciences

  2. Nanotechnology/Materials / Synthetic organic chemistry

Research History 3

  1. Nagoya University   Assistant Professor

    2017.8

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    Country:Japan

  2. Takeda Pharmaceutical Company Limited

    2013.4 - 2017.7

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    Country:Japan

  3. 日本学術振興会 特別研究員 DC1

    2010.4 - 2013.3

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    Country:Japan

Education 2

  1. Nagoya University   Graduate School, Division of Engineering

    - 2013.3

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    Country: Japan

  2. Nagoya University   Faculty of Engineering

    - 2008.3

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    Country: Japan

Professional Memberships 3

  1. 日本化学会

  2. 日本薬学会

  3. 有機合成化学協会

Awards 1

  1. 日本薬学会東海支部学術奨励賞

    2022.7   日本薬学会東海支部  

    安井 猛

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    Award type:Award from Japanese society, conference, symposium, etc. 

 

Papers 35

  1. Enantioselective Desymmetrization of Trifluoromethylated Tertiary Benzhydrols via Hydrogen-Acceptor-Free Ir-Catalyzed Dehydrogenative C-H Silylation: Decisive Role of the Trifluoromethyl Group. Reviewed

    Yamamoto Y, Tadano R, Yasui T

    JACS Au   Vol. 4 ( 2 ) page: 807 - 815   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JACS Au  

    Although the trifluoromethyl (CF3) group is one of the most important fluorinated groups owing to its significant ability to modulate pharmacological properties, constructing trifluoromethylated stereogenic centers in an enantioselective manner has been a formidable challenge. Herein, we report the development of the enantioselective desymmetrization of trifluoromethylated benzhydrols via intramolecular dehydrogenative silylation using Ir catalysts with chiral pyridine-oxazoline (PyOX) ligands. The produced benzoxasilol was transformed into several unsymmetrical benzhydrols via iododesilylation and subsequent transition-metal-catalyzed cross-coupling reactions. Moreover, the same Ir catalyst system was used for the kinetic resolution of unsymmetrical trifluoromethylated benzhydrols.

    DOI: 10.1021/jacsau.3c00794

    Scopus

    PubMed

  2. Cobalt/Organophotoredox Dual Catalysis-Enabled Cyclization of 1,5,10-Enediynes Involving Metallole-Mediated Remote C(sp3)-H Bond Activation Leading to Axially Chiral Alkenes Reviewed

    Keiji Yamada, Nobuaki Koga, Takeshi Yasui, Yoshihiko Yamamoto

    ACS Catalysis     2024.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi/10.1021/acscatal.3c05848

  3. 生物活性分子にみられる多環式骨格の一挙構築を可能にする触媒的環化異性化反応の開発 Invited Reviewed

    Takeshi Yasui

    YAKUGAKU ZASSHI   Vol. 143 ( 11 ) page: 889 - 895   2023.11

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1248/yakushi.23-00127

    Scopus

    PubMed

  4. Rh(III)-Catalyzed Highly Site- and Regio-Selective Alkenyl C–H Activation/Annulation of 4-Amino-2-Quinolones with Alkynes via Reversible Alkyne Insertion Reviewed

    Naohiro Hirako, Takeshi Yasui, Yoshihiko Yamamoto

    Chemical Science     2023.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1039/D3SC03987K

  5. Cycloaddition of Cyclopropenes with Alkynes via Carbon-Carbon Double Bond Cleavage Enabled by a Ruthenium Catalyst: Synthesis of Cyclopentadienes and Cycloheptatrienes Reviewed

    Kikuchi Tomohiro, Yasui Takeshi, Yamamoto Yoshihiko

    ACS CATALYSIS   Vol. 13 ( 14 ) page: 9656 - 9666   2023.7

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:ACS Catalysis  

    Transition-metal-mediated carbon-carbon single-bond cleavage of cyclopropenes has been widely exploited in organic synthesis. However, the ring-opening of cyclopropenes via the cleavage of their carbon-carbon double bond remains a formidable challenge. Herein, we report an intramolecular cycloaddition of cyclopropenes with alkynes via cleavage of the carbon-carbon double bond of cyclopropenes enabled by a ruthenium catalyst to afford 1,2-fused cyclopentadienes, which are difficult to access by conventional synthetic methods. Density functional theory calculations indicate that the reaction proceeds via a cyclopropane-fused ruthenacycle that undergoes ring expansion to generate a six-membered cyclic biscarbenoid. We also synthesized fused cycloheptatrienes via the cycloaddition of cyclopropene-diynes.

    DOI: 10.1021/acscatal.3c02543

    Web of Science

    Scopus

  6. Trifluoromethylated Oxidopyridinium Betaines: Unique (5+2) Cycloaddition Selectivity Imposed by 2-or 6-Trifluoromethyl Groups Reviewed

    Yamamoto Yoshihiko, Tazawa Syunji, Tadano Ryu, Yasui Takeshi

    CHEMISTRY-AN ASIAN JOURNAL   Vol. 18 ( 10 ) page: e202300211   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Chemistry - An Asian Journal  

    Despite the significant advances in trifluoromethylation methods, the synthesis of complex trifluoromethylated molecules, bearing a natural-product-like three-dimensional framework, remains as a formidable challenge. Therefore, the cycloaddition of unprecedented CF3-substituted oxidopyridinium betaines was investigated. After the methylation of trifluoromethylated pyridin-3-ols with methyl triflate, pyridinium ions generated in-situ were treated with triethylamine in the presence of N-methylmaleimide to produce trifluoromethylated 8-azabicyclo[3.2.1]octane derivatives via (5+2) cycloaddition of the corresponding oxidopyridinium betaines. Exo/endo-selectivity varied depending on the positions of the CF3 substituents; endo-products were preferred in the reactions of oxidopyridinium betaines with the CF3 group at the 2- or 6-positions, whereas the 5-CF3-substituted betaine exclusively produced an exo-product. Moreover, unique regio- and stereoselectivities have been observed in the reactions of 2- or 6-CF3-substituted oxidopyridinium betaines with vinyl sulfones and trans-1,2-disubstituted alkenes. To gain insight into the reactivity of trifluoromethylated oxidopyridinium betaines, computational investigations were also conducted.

    DOI: 10.1002/asia.202300211

    Web of Science

    Scopus

    PubMed

  7. Oxidopyridinium Cycloadditions Revisited: A Combined Computational and Experimental Study on the Reactivity of 1-(2-Pyrimidyl)-3-oxidopyridinium Betaine Reviewed

    Yoshihiko Yamamoto, Yudai Shizume, Syunji Tazawa, Takeshi Yasui

    The Journal of Organic Chemistry     2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1021/acs.joc.2c02971

  8. Construction of Diverse Poly cyclic Structures via Group 9 Metal-Catalyzed Cycloisomerization of 1,6-Diyne Derivatives Reviewed

    Yasui T., Yamamoto Y.

    Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry   Vol. 81 ( 2 ) page: 127 - 138   2023

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry  

    Polycyclic structures are found in many natural products and pharmaceuticals. The transition-metal-catalyzed cycloisomerization of unsaturated compounds is one of the most powerful methods for construction of polycyclic frameworks in a single operation. In particular, 1,6-diyne is the structural motif widely used for the cycloisomerization as it readily reacts with low-valent metal catalysts to form metallacyclopentadiene intermediates. However, this method has been mainly exploited for the synthesis of aromatic compounds such as benzenes and pyridines. This article describes our recent studies regarding the synthesis of various polycyclic structures including non-aromatic carbocycles, such as 5-6-5 tricyclic cyclohexadienes bearing a quaternary bridgehead carbon and tetralone-containing exocyclic dienes, via the group 9 metal-catalyzed cycloisomerization reaction of 1,6-diyne derivatives. In the course of our study, we elucidated that the cobalt/photoredox dual catalysis is very efficient for the cycloisomerization of 1,6-diyne derivatives such as enediynes. We also found a novel cascade cyclization of 1,6-diynyl esters to form various cyclic compounds through the formation of vinylallene intermediates.

    DOI: 10.5059/yukigoseikyokaishi.81.127

    Scopus

  9. Concise Synthesis of Functionalized Cyclopentadienyl Rhodium(III) Complexes via Suzuki–Miyaura Cross Coupling Reviewed

    Takeshi Yasui, Shouta Tanabe, Takuya Masueda, Yoshihiko Yamamoto

    Synthesis     2022.11

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/a-1983-4777

  10. Combined Computational and Experimental Study on [5 + 2] Cycloaddition of 2-Trifluoromethylated Oxidopyrylium Species Leading to 1-(Trifluoromethyl)-8-oxabicyclo[3.2.1]oct-3-en-2-ones Reviewed

    Yoshihiko Yamamoto, Yuya Nakazato, Ryu Tadano, Takeshi Yasui

    Journal of Organic Chemistry     2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1021/acs.joc.2c01189

  11. Co-Catalyzed atom transfer radical addition of bromodifluoroacetamides, expanding the scope of radical difluoroalkylation Reviewed

    Yoshihiko Yamamoto, Harufumi Suzuki, Eisuke Kuroyanagi, Keiji Yamada, Takeshi Yasui

    Organic & Biomolecular Chemistry     2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1039/D2OB00437B

  12. Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain Reviewed

    Aya Sakaki, Takeshi Yasui, Masashi Watanabe, Rine Tatsumi, Yoshihiko Yamamoto, Wataru Takano, Yuki Tani, Izumi Okamura, Hirokazu Hirai, Shigeki Takeda

    Genes to Cells     2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1111/gtc.12931

  13. Cobalt/Organophotoredox Dual-Catalysis-Enabled Cascade Cyclization of 1,6-Diynyl Esters via Formal 1,8-Acyloxy Migration Reviewed

    Takeshi Yasui, Keiji Yamada, Rine Tatsumi, Yoshihiko Yamamoto

    ACS Catalysis     2021.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1021/acscatal.1c03704

  14. Catalyst-Free Csp−Csp3 Cross-Coupling of Bromodifluoroacetamides with 1-Iodoalkynes under Visible-Light Irradiation Reviewed

    Yoshihiko Yamamoto, Eisuke Kuroyanagi, Harufumi Suzuki, Takeshi Yasui

    Advanced Synthesis & Catalysis     2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1002/adsc.202100846

  15. Highly Enantioselective [2+2+2] Cycloaddition of Enediynes Enabled by Cobalt/Organophotoredox Cooperative Catalysis Reviewed

    Takeshi Yasui, Rine Tatsumi, and Yoshihiko Yamamoto

    ACS Catalysis     2021.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1021/acscatal.1c02410

  16. Enantioselective Construction of 5-6-5 Tricyclic Lactone Framework Bearing a Quaternary Bridgehead Carbon via Rh-Catalyzed Asymmetric [2+2+2] Cycloaddition of Enediynes Reviewed

    Takeshi Yasui, Yuya Nakazato, Koutarou Kurisaki, and Yoshihiko Yamamoto

    Advanced Synthesis & Catalysis     2021.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1002/adsc.202100513

  17. Synthesis of Benzo-Fused Cyclic Ketones via Metal-Free Ring Expansion of Cyclopropanols Enabled by Proton-Coupled Electron Transfer Reviewed

    Tomohiro Kikuchi, Keiji Yamada, Takeshi Yasui, Yoshihiko Yamamoto

    Organic Letters     2021.6

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1021/acs.orglett.1c01436

  18. Synthesis of difluoromethylated diarylmethanes via Fe(OTf)3-catalyzed Friedel–Crafts reaction of 2,2-difluoro-1-arylethyl phosphates Reviewed

    Yoshihiko Yamamoto, Tomoya Takase, Eisuke Kuroyanagi, Takeshi Yasui

    Chemical Communications     2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  19. A Combined Experimental and Computational Study on the Palladium-Catalyzed Sequential [2+2+1] Spirocyclization/Arene C–H Activation of 4-Iodo-2-quinolones with Diphenylacetylene Reviewed

    Yoshihiko Yamamoto, Naohiro Hirako, Takeshi Yasui

    Bulletin of the Chemical Society of Japan     2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  20. Synthesis of 1-(Difluoromethyl)alk-1-enes via Palladium-Catalyzed S(N)2 '-Type Substitution Reaction of Difluoromethylated Allylic Phosphates with 1,3-Dicarbonyl Compounds and Imides Reviewed

      Vol. 86 ( 1 ) page: 1053 - 1064   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.0c02538

    Web of Science

  21. Rhodium-catalyzed cycloisomerization of ester-tethered 1,6-diynes with cyclopropanol moiety leading to tetralone/exocyclic diene hybrid molecules. Reviewed

    Yasui T, Kikuchi T, Yamamoto Y

    Chemical communications (Cambridge, England)     2020.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d0cc05429a

    PubMed

  22. Palladium-Catalyzed [3+2] and [2+2+2] Annulations of 4-Iodo-2-quinolones with Activated Alkynes through Selective C-H Activation Reviewed

    Yamamoto Yoshihiko, Jiang Jiyue, Yasui Takeshi

    CHEMISTRY-A EUROPEAN JOURNAL   Vol. 26 ( 17 ) page: 3749-3757   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chem.201904558

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  23. Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations. Reviewed

    Li J, Fukase Y, Shang Y, Zou W, Muñoz-Félix JM, Buitrago L, van Agthoven J, Zhang Y, Hara R, Tanaka Y, Okamoto R, Yasui T, Nakahata T, Imaeda T, Aso K, Zhou Y, Locuson C, Nesic D, Duggan M, Takagi J, Vaughan RD, Walz T, Hodivala-Dilke K, Teitelbaum SL, Arnaout MA, Filizola M, Foley MA, Coller BS

      Vol. 2 ( 6 ) page: 387-401   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsptsci.9b00041

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  24. Synthesis of (Difluoromethyl)cycloalkenes from 2-Cycloalkenones by Utilizing Phospha-Brook Rearrangement Reviewed

    Yamamoto Yoshihiko, Ishida Yuki, Takamizu Yosuke, Yasui Takeshi

    ADVANCED SYNTHESIS & CATALYSIS   Vol. 361 ( 16 ) page: 3739-3743   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/adsc.201900469

    Web of Science

  25. SYNTHESIS OF gamma-DIFLUOROMETHYLATED TETRONATE DERIVATIVES FROM SQUARATES USING DIFLUOROMETHYLPHOSPHONATE

    Yamamoto Yoshihiko, Ishida Yuki, Kurohara Takashi, Shibuya Masatoshi, Yasui Takeshi

    HETEROCYCLES   Vol. 99 ( 1 ) page: 363-378   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3987/COM-18-S(F)29

    Web of Science

  26. The vinylogous Catellani reaction: a combined computational and experimental study

    Yamamoto Y., Murayama T., Jiang J., Yasui T., Shibuya M.

    CHEMICAL SCIENCE   Vol. 9 ( 5 ) page: 1191-1199   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c7sc04265e

    Web of Science

  27. Combined Experimental and Computational Study on Catalytic Cyclocoupling of Epxides and CO2 Using Porphyrin-Based Cu(II) Metal-Organic Frameworks with 2D Coordination Networks Reviewed

    Tsukasa Murayama, Masayuki Asano, Tetsushi Ohmura, Arimitsu Usuki, Takeshi Yasui, Yoshihiko Yamamoto

    Bull. Chem. Soc. Jpn.   Vol. 91   page: 383-390   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/bcsj.20170371

  28. Chiral Hypervalent Organoiodine-Catalyzed Enantioselective Oxidative Spirolactonization of Naphthol Derivatives

    Uyanik Muhammet, Yasui Takeshi, Ishihara Kazuaki

    JOURNAL OF ORGANIC CHEMISTRY   Vol. 82 ( 22 ) page: 11946-11953   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.7b01941

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    PubMed

  29. Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.

    Yasui T, Yamamoto T, Sakai N, Asano K, Takai T, Yoshitomi Y, Davis M, Takagi T, Sakamoto K, Sogabe S, Kamada Y, Lane W, Snell G, Iwata M, Goto M, Inooka H, Sakamoto JI, Nakada Y, Imaeda Y

    Bioorganic & medicinal chemistry   Vol. 25 ( 17 ) page: 4876-4886   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmc.2017.07.037

    PubMed

  30. Hydrogen Bonding and Alcohol Effects in Asymmetric Hypervalent Iodine Catalysis: Enantioselective Oxidative Dearomatization of Phenols Reviewed

    Muhammet Uyanik, Takeshi Yasui, Kazuaki Ishihara

    Angewandte Chemie International Edition   Vol. 52 ( 35 ) page: 9215-9218   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201303559

  31. In Situ Generated (Hypo)Iodite Catalysts for the Direct alpha-Oxyacylation of Carbonyl Compounds with Carboxylic Acids Reviewed

    Dr. Muhammet Uyanik, Daisuke Suzuki, Takeshi Yasui, Kazuaki Ishihara

    Angewandte Chemie International Edition   Vol. 50 ( 23 ) page: 5331-5334   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201101522

  32. Enantioselective Kita Oxidative Spirolactonization Catalyzed by In Situ Generated Chiral Hypervalent Iodine(III) Species Reviewed

    Muhammet Uyanik, Takeshi Yasui, Kazuaki Ishihara

    Angewandte Chemie International Edition   Vol. 49   page: 2175-2177   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.200907352

  33. Chiral Hypervalent Iodine-Catalyzed Enantioselective Oxidative Kita Spirolactonization of 1-Naphthol Derivatives and One-Pot Diastereoselective Oxidation to Epoxyspirolactones Invited Reviewed

    Muhammet Uyanik, Takeshi Yasui, Kazuaki Ishihara

    Tetrahedron   Vol. 66 ( 31 ) page: 5841-5851   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tet.2010.04.060

  34. Quaternary Ammonium (Hypo)iodite Catalysis for Enantioselective Oxidative Cycloetherification Reviewed

    Muhammet Uyanik, Hiroaki Okamoto, Takeshi Yasui, Kazuaki Ishihara

    Science   Vol. 328 ( 5984 ) page: 1376-1379   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.1188217

  35. Hypervalent Iodine-Catalyzed Oxylactonization of Ketocarboxylic Acids to Ketolactones Invited Reviewed

    Muhammet Uyanik, Takeshi Yasui, Kazuaki Ishihara

    Bioorganic & Medicinal Chemistry Letters   Vol. 19   page: 3848-3851   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmcl.2009.03.148

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MISC 2

  1. 熱力学の壁を超えろ! :内部アルケンから末端アルケンへの異性化

    安井 猛

    ファルマシア   Vol. 58 ( 10 ) page: 974   2022.10

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    Language:Japanese  

  2. ニトロメタンから窒素原子を取りだす!?危険な反応をより安全に行える新手法 Invited

    月刊「化学」   Vol. 75 ( 5 ) page: 71 - 72   2020.5

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    Language:Japanese  

Presentations 35

  1. コバルト/光レドックス協働触媒を用いる1,6-ジインとアルケンの不斉[2+2+2]環化付加反応の開発

    中川琴子、石川祐輝、山田啓士、安井 猛、山本芳彦

    日本薬学会第144年会  2024.3.30 

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    Event date: 2024.3

    Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜  

  2. 可視光駆動型コバルト触媒を利用する遠隔位C(sp3)-H結合活性化を伴う環化異性化反応の開発

    山田啓士、安井 猛、山本芳彦

    日本薬学会第144年会  2024.3.29 

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    Event date: 2024.3

    Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜  

  3. 熱力学制御による位置選択的C-H官能基化を利用した3,4-縮環2-キノロン誘導体の合成

    平子直洋、安井 猛、山本芳彦

    第52回 複素環化学討論会  2023.10.12 

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    Event date: 2023.10

    Presentation type:Oral presentation (general)  

    Venue:東北大学  

  4. Cobalt/Organophotoredox Dual Catalysis-Enabled Cycloisomerization of 1,5,10-Endiynes via C-H Activation

    2023.9.13 

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    Event date: 2023.9

    Presentation type:Oral presentation (general)  

  5. Rh (III) 触媒によるC-H 官能基化を利用した3,4-縮環2-キノロン誘導体の合成とその機構研究

    平子直洋,安井猛,山本芳彦

    第69回日本薬学会東海支部大会  2023.7.8  日本薬学会東海支部

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    Event date: 2023.7

    Presentation type:Oral presentation (general)  

    Venue:名古屋大学  

  6. コバルト/光レドックス協働触媒によるビアリール化合物の不斉合成

    川又匠,安井猛,山本芳彦

    第69回日本薬学会東海支部大会  2023.7.8  日本薬学会東海支部

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    Event date: 2023.7

    Presentation type:Oral presentation (general)  

  7. ルテニウム触媒によるシクロプロペンの炭素-炭素二重結合の切断を利用する縮環シクロペンタジエンと縮環シクロヘプタトリエンの合成

    菊池友宏、安井猛、山本芳彦

    日本化学会第103春季年会  2023.3.24 

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    Event date: 2023.3

    Presentation type:Oral presentation (general)  

  8. 可視光駆動型コバルト触媒を利用するC-H結合活性化を伴うエンジインの環化異性化反応

    山田啓士、安井猛、山本芳彦

    日本化学会第103春季年会  2023.3.22 

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    Event date: 2023.3

    Presentation type:Oral presentation (general)  

  9. Cp*Rh(III)錯体を用いる位置選択的C-H官能基化を利用した3,4-縮環2-キノロン誘導体の合成

    平子直洋、安井猛、山本芳彦

    日本化学会第103春季年会  2023.3.22 

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    Event date: 2023.3

    Presentation type:Oral presentation (general)  

  10. 鎖状ジインから多彩な環骨格の一挙構築を実現する光/コバルト協働触媒反応の開発

    安井 猛

    創薬等先端技術支援基盤プラットフォーム(BINDS)第4回合成勉強会  2023.3.11 

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    Event date: 2023.3

    Presentation type:Oral presentation (invited, special)  

    Venue:京都大学  

  11. ルテニウム触媒によるシクロプロペン-イン類の環化異性化反応jを利用した縮環シクロペンタジエンおよびシクロヘプタトリエンの合成

    菊池友宏、安井猛、山本芳彦

    第68回有機金属化学討論会  2022.9.8 

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    Event date: 2022.9

    Presentation type:Oral presentation (general)  

    Venue:オンライン  

  12. ロジウム(III)触媒による2-キノロンとアルキンを用いる位置選択的C-H活性化/環化反応

    平子直洋、安井猛、山本芳彦

    第68回有機金属化学討論会  2022.9.6 

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    Event date: 2022.9

    Presentation type:Poster presentation  

    Venue:オンライン  

  13. 可視光駆動型コバルト触媒を利用するC-H結合切断を伴うエンジインの環化異性化反応

    山田啓士、安井猛、山本芳彦

    第68回有機金属化学討論会  2022.9.6 

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    Event date: 2022.9

    Presentation type:Poster presentation  

    Venue:オンライン  

  14. 遷移金属触媒を駆使する1,6-ジイン誘導体から多彩な環構造へのアプローチ Invited

    安井猛

    第68回日本薬学会東海支部大会 学術奨励賞 受賞講演  2022.7.9  日本薬学会

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    Event date: 2022.7

    Presentation type:Oral presentation (invited, special)  

    Venue:愛知学院大学  

  15. ロジウム触媒を用いるC-H活性化を利用した3,4-縮環2-キノロンの合成

    平子直洋、安井猛、山本芳彦

    第68回日本薬学会東海支部大会  2022.7.9  日本薬学会

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    Event date: 2022.7

    Presentation type:Oral presentation (general)  

    Venue:愛知学院大学  

  16. ルテニウム触媒を用いるシクロプロペンの新規活性化法を利用した環拡大反応の開発

    菊池友宏、安井猛、山本芳彦

    第68回日本薬学会東海支部大会  2022.7.9  日本薬学会

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    Event date: 2022.7

    Presentation type:Oral presentation (general)  

    Venue:愛知学院大学  

  17. 可視光駆動型コバルト触媒を利用するC-H結合切断を伴うエンジインの環化異性化反応

    山田啓士、安井猛、山本芳彦

    第68回日本薬学会東海支部大会  2022.7.9  日本薬学会

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    Event date: 2022.7

    Presentation type:Oral presentation (general)  

    Venue:愛知学院大学  

  18. ルテニウム触媒を用いるシクロプロペン-イン類の環化異性化反応を利用した非芳香族分子の合成

    菊池友宏、安井猛、山本芳彦

    創薬懇話会2022 in 名古屋  2022.6.30  日本薬学会

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    Event date: 2022.6 - 2022.7

    Presentation type:Poster presentation  

    Venue:オンライン  

  19. ロジウム触媒を?いるC-H 活性化を利用した3,4 縮環2-キノロンの合成

    平子直洋、安井猛、山本芳彦

    創薬懇話会2022 in 名古屋  2022.6.30  日本薬学会

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    Event date: 2022.6 - 2022.7

    Presentation type:Poster presentation  

    Venue:オンライン  

  20. 可視光駆動型コバルト触媒を利用するC-H 結合切断を伴うエンジインの環化異性化反応

    山田啓士、安井猛、山本芳彦

    創薬懇話会2022 in 名古屋  2022.6.30  日本薬学会

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    Event date: 2022.6 - 2022.7

    Presentation type:Poster presentation  

    Venue:オンライン  

  21. プロトン共役電子移動を起点としたシクロプロパノール誘導体の触媒的環拡大反応を利用するベンゼン縮環環状ケトンの合成

    菊池友宏、安井猛、山本芳彦

    日本薬学会第142年会  2022.3.28  日本薬学会

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  22. Rh触媒を用いたC-H活性化による縮環キノロン誘導体の合成

    平子直洋、安井猛、山本芳彦

    日本薬学会第142年会  2022.3.27  日本薬学会

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  23. 可視光駆動型コバルト触媒を利用した形式的1,8-アシロキシ転移を伴う1,6-ジイニルエステルのカスケード型環化反応の開発

    山田啓士、安井猛、山本芳彦

    日本薬学会第142年会  2022.3.27  日本薬学会

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  24. Enantioselective [2+2+2] Cycloaddition of Enediynes Enabled by Cobalt-Organophotoredox Cooperative Catalysis

    Takeshi Yasui, Rine Tatsumi, Yoshihiko Yamamoto

    2021.9.7 

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    Event date: 2021.9

    Presentation type:Poster presentation  

  25. コバルト/光レドックス触媒によるエステル含有1,6-ジインの環化異性化反応による1-ナフトール誘導体の合成

    山田啓士、安井猛、山本芳彦

    第67回有機金属化学討論会  2021.9.7 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Poster presentation  

  26. プロトン共役電子移動を利用するシクロプロパノール誘導体の触媒的環拡大反応の開発

    菊池友宏,安井猛,山本芳彦

    第67回日本薬学会東海支部大会  2021.7.3 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  27. 可視光駆動型コバルト触媒を用いるエステル含有1,6-ジインの環化異性化反応による1-ナフトール誘導体の合成

    山田啓士,巽理寧、安井猛,山本芳彦

    第67回日本薬学会東海支部大会  2021.7.3 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  28. 可視光駆動型コバルト触媒を用いるエンジインの不斉[2+2+2]環化付加反応の開発

    安井猛,巽理寧、山本芳彦

    第67回日本薬学会東海支部大会  2021.7.3 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  29. コバルト/光レドックス触媒を利用するエステル含有1,6-ジインの環化異性化反応による1-ナフトール誘導体の合成

    山田啓士、安井猛、山本芳彦

    日本化学会第101春季年会  2021.3.19  日本化学会

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  30. ロジウム触媒を用いるシクロプロパノール含有1,6-ジインの環化異性化反応によるらせん状エキソジエン骨格の構築

    菊池友宏、安井猛、山本芳彦 2020

    日本化学会第101春季年会  2021.3.19  日本化学会

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    Event date: 2021.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  31. ロジウム触媒を用いるシクロプロパノール含有1,6-ジインの環化異性化反応によるらせん状エキソジエン骨格の合成

    菊池友宏、安井猛、山本芳彦

    日本薬学会第140年会 

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    Event date: 2020.3

  32. キラルカチオン性ロジウム触媒を用いるエンジインの不斉[2+2+2]付加環化反応の開発

    安井猛,栗崎晃太郎、山本芳彦

    日本薬学会第140年会 

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    Event date: 2020.3

  33. ロジウム触媒を用いるエンジインの[2+2+2]環化付加反応による5-6-5三環性ラクトン骨格の不斉合成

    安井猛,栗崎晃太郎、山本芳彦

    第66回有機金属化学討論会  2019.9.14 

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    Event date: 2019.9 - 0219.9

    Presentation type:Oral presentation (general)  

  34. キラルロジウム触媒を用いるエンジインの[2+2+2]環化付加反応による5-6-5三環性ラクトン骨格の不斉合成

    栗崎晃太朗、安井猛、山本芳彦

    日本化学会第99春季年会  2019.3.17 

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    Event date: 2019.3

    Presentation type:Oral presentation (general)  

  35. ロジウム触媒を用いる1,6-ジインの環化異性化反応によるらせん状エキソジエン骨格の合成

    菊池友宏、安井猛、山本芳彦

    日本化学会第99春季年会  2019.3.17 

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    Event date: 2019.3

    Presentation type:Oral presentation (general)  

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Research Project for Joint Research, Competitive Funding, etc. 2

  1. 炭素-炭素結合活性化を鍵とする新規環化異性化反応の開発

    2022.8 - 2023.7

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1500000

  2. 遷移金属触媒を用いる光学活性らせん性環状エキソジエン合成法の開発

    Grant number:200052  2020.11 - 2022.11

    住友財団 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1500000 ( Direct Cost: \1500000 )

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. コバルト/光レドックス協働触媒が拓くσ結合活性化を伴う環化異性化反応

    Grant number:21K05051  2021.4 - 2024.3

    基盤研究(C)

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    Authorship:Principal investigator 

 

Teaching Experience (On-campus) 22

  1. 化学生命工学実験3

    2021

  2. 化学生命工学実験2

    2021

  3. Organic Chemistry Research Advanced Course

    2021

  4. Seminar in Organic Chemistry IIC

    2021

  5. Seminar in Organic Chemistry IIA

    2021

  6. Organic Chemistry Research Course

    2021

  7. Seminar in Organic Chemistry ⅠB

    2021

  8. Seminar in Organic Chemistry ⅠA

    2021

  9. Organic Chemistry 4 with Exercises

    2021

  10. Seminar in Organic Chemistry IID

    2021

  11. Seminar in Organic Chemistry IIB

    2021

  12. Basic Training for Crossover Research Course

    2021

  13. Advanced Organic Chemistry

    2021

  14. Basic Training for Crossover Research

    2021

  15. Organic Chemistry 4 with Exercises

    2020

  16. Organic Chemistry Research Course

    2020

  17. Seminar in Organic Chemistry ⅠB

    2020

  18. Seminar in Organic Chemistry ⅠA

    2020

  19. 創薬有機化学実習

    2020

  20. 化学生命工学実験3

    2020

  21. 化学生命工学実験2

    2020

  22. 創薬有機化学セミナーⅡB

    2020

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Social Contribution 1

  1. 愛知県立豊田西高等学校 出前講義

    Role(s):Lecturer

    愛知県立豊田西高等学校  2020.11