Updated on 2022/03/29

写真a

 
YASUI Takeshi
 
Organization
Graduate School of Pharmaceutical Sciences Department of Basic Medicinal Sciences Organic Chemistry Assistant Professor
Graduate School
Graduate School of Pharmaceutical Sciences
Undergraduate School
School of Engineering Chemistry and Biotechnology
Title
Assistant Professor

Degree 1

  1. 博士(工学) ( 2013.3   名古屋大学 ) 

Research Areas 2

  1. Life Science / Pharmaceutical chemistry and drug development sciences

  2. Nanotechnology/Materials / Synthetic organic chemistry

Research History 3

  1. Nagoya University   Assistant Professor

    2017.8

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    Country:Japan

  2. Takeda Pharmaceutical Company Limited

    2013.4 - 2017.7

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    Country:Japan

  3. 日本学術振興会 特別研究員 DC1

    2010.4 - 2013.3

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    Country:Japan

Education 2

  1. Nagoya University   Graduate School, Division of Engineering

    - 2013.3

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    Country: Japan

  2. Nagoya University   Faculty of Engineering

    - 2008.3

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    Country: Japan

Professional Memberships 3

  1. 日本化学会

  2. 日本薬学会

  3. 有機合成化学協会

 

Papers 25

  1. Co-Catalyzed atom transfer radical addition of bromodifluoroacetamides, expanding the scope of radical difluoroalkylation Reviewed

    Yoshihiko Yamamoto, Harufumi Suzuki, Eisuke Kuroyanagi, Keiji Yamada, Takeshi Yasui

    Organic & Biomolecular Chemistry     2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1039/D2OB00437B

  2. Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain Reviewed

    Aya Sakaki, Takeshi Yasui, Masashi Watanabe, Rine Tatsumi, Yoshihiko Yamamoto, Wataru Takano, Yuki Tani, Izumi Okamura, Hirokazu Hirai, Shigeki Takeda

    Genes to Cells     2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1111/gtc.12931

  3. Cobalt/Organophotoredox Dual-Catalysis-Enabled Cascade Cyclization of 1,6-Diynyl Esters via Formal 1,8-Acyloxy Migration Reviewed

    Takeshi Yasui, Keiji Yamada, Rine Tatsumi, Yoshihiko Yamamoto

    ACS Catalysis     2021.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1021/acscatal.1c03704

  4. Catalyst-Free Csp−Csp3 Cross-Coupling of Bromodifluoroacetamides with 1-Iodoalkynes under Visible-Light Irradiation Reviewed

    Yoshihiko Yamamoto, Eisuke Kuroyanagi, Harufumi Suzuki, Takeshi Yasui

    Advanced Synthesis & Catalysis     2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1002/adsc.202100846

  5. Highly Enantioselective [2+2+2] Cycloaddition of Enediynes Enabled by Cobalt/Organophotoredox Cooperative Catalysis Reviewed

    Takeshi Yasui, Rine Tatsumi, and Yoshihiko Yamamoto

    ACS Catalysis     2021.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1021/acscatal.1c02410

  6. Enantioselective Construction of 5-6-5 Tricyclic Lactone Framework Bearing a Quaternary Bridgehead Carbon via Rh-Catalyzed Asymmetric [2+2+2] Cycloaddition of Enediynes Reviewed

    Takeshi Yasui, Yuya Nakazato, Koutarou Kurisaki, and Yoshihiko Yamamoto

    Advanced Synthesis & Catalysis     2021.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1002/adsc.202100513

  7. Synthesis of Benzo-Fused Cyclic Ketones via Metal-Free Ring Expansion of Cyclopropanols Enabled by Proton-Coupled Electron Transfer Reviewed

    Tomohiro Kikuchi, Keiji Yamada, Takeshi Yasui, Yoshihiko Yamamoto

    Organic Letters     2021.6

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1021/acs.orglett.1c01436

  8. Synthesis of difluoromethylated diarylmethanes via Fe(OTf)3-catalyzed Friedel–Crafts reaction of 2,2-difluoro-1-arylethyl phosphates Reviewed

    Yoshihiko Yamamoto, Tomoya Takase, Eisuke Kuroyanagi, Takeshi Yasui

    Chemical Communications     2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  9. A Combined Experimental and Computational Study on the Palladium-Catalyzed Sequential [2+2+1] Spirocyclization/Arene C–H Activation of 4-Iodo-2-quinolones with Diphenylacetylene Reviewed

    Yoshihiko Yamamoto, Naohiro Hirako, Takeshi Yasui

    Bulletin of the Chemical Society of Japan     2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  10. Synthesis of 1-(Difluoromethyl)alk-1-enes via Palladium-Catalyzed S(N)2 '-Type Substitution Reaction of Difluoromethylated Allylic Phosphates with 1,3-Dicarbonyl Compounds and Imides Reviewed

      Vol. 86 ( 1 ) page: 1053 - 1064   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.0c02538

    Web of Science

  11. Rhodium-catalyzed cycloisomerization of ester-tethered 1,6-diynes with cyclopropanol moiety leading to tetralone/exocyclic diene hybrid molecules. Reviewed

    Yasui T, Kikuchi T, Yamamoto Y

    Chemical communications (Cambridge, England)     2020.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d0cc05429a

    PubMed

  12. Palladium-Catalyzed [3+2] and [2+2+2] Annulations of 4-Iodo-2-quinolones with Activated Alkynes through Selective C-H Activation Reviewed

    Yamamoto Yoshihiko, Jiang Jiyue, Yasui Takeshi

    CHEMISTRY-A EUROPEAN JOURNAL   Vol. 26 ( 17 ) page: 3749-3757   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chem.201904558

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  13. Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations. Reviewed

    Li J, Fukase Y, Shang Y, Zou W, Muñoz-Félix JM, Buitrago L, van Agthoven J, Zhang Y, Hara R, Tanaka Y, Okamoto R, Yasui T, Nakahata T, Imaeda T, Aso K, Zhou Y, Locuson C, Nesic D, Duggan M, Takagi J, Vaughan RD, Walz T, Hodivala-Dilke K, Teitelbaum SL, Arnaout MA, Filizola M, Foley MA, Coller BS

      Vol. 2 ( 6 ) page: 387-401   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsptsci.9b00041

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  14. Synthesis of (Difluoromethyl)cycloalkenes from 2-Cycloalkenones by Utilizing Phospha-Brook Rearrangement Reviewed

    Yamamoto Yoshihiko, Ishida Yuki, Takamizu Yosuke, Yasui Takeshi

    ADVANCED SYNTHESIS & CATALYSIS   Vol. 361 ( 16 ) page: 3739-3743   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/adsc.201900469

    Web of Science

  15. SYNTHESIS OF gamma-DIFLUOROMETHYLATED TETRONATE DERIVATIVES FROM SQUARATES USING DIFLUOROMETHYLPHOSPHONATE

    Yamamoto Yoshihiko, Ishida Yuki, Kurohara Takashi, Shibuya Masatoshi, Yasui Takeshi

    HETEROCYCLES   Vol. 99 ( 1 ) page: 363-378   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3987/COM-18-S(F)29

    Web of Science

  16. The vinylogous Catellani reaction: a combined computational and experimental study

    Yamamoto Y., Murayama T., Jiang J., Yasui T., Shibuya M.

    CHEMICAL SCIENCE   Vol. 9 ( 5 ) page: 1191-1199   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c7sc04265e

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  17. Combined Experimental and Computational Study on Catalytic Cyclocoupling of Epxides and CO2 Using Porphyrin-Based Cu(II) Metal-Organic Frameworks with 2D Coordination Networks Reviewed

    Tsukasa Murayama, Masayuki Asano, Tetsushi Ohmura, Arimitsu Usuki, Takeshi Yasui, Yoshihiko Yamamoto

    Bull. Chem. Soc. Jpn.   Vol. 91   page: 383-390   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/bcsj.20170371

  18. Chiral Hypervalent Organoiodine-Catalyzed Enantioselective Oxidative Spirolactonization of Naphthol Derivatives

    Uyanik Muhammet, Yasui Takeshi, Ishihara Kazuaki

    JOURNAL OF ORGANIC CHEMISTRY   Vol. 82 ( 22 ) page: 11946-11953   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.7b01941

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  19. Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.

    Yasui T, Yamamoto T, Sakai N, Asano K, Takai T, Yoshitomi Y, Davis M, Takagi T, Sakamoto K, Sogabe S, Kamada Y, Lane W, Snell G, Iwata M, Goto M, Inooka H, Sakamoto JI, Nakada Y, Imaeda Y

    Bioorganic & medicinal chemistry   Vol. 25 ( 17 ) page: 4876-4886   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmc.2017.07.037

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  20. Hydrogen Bonding and Alcohol Effects in Asymmetric Hypervalent Iodine Catalysis: Enantioselective Oxidative Dearomatization of Phenols Reviewed

    Muhammet Uyanik, Takeshi Yasui, Kazuaki Ishihara

    Angewandte Chemie International Edition   Vol. 52 ( 35 ) page: 9215-9218   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201303559

  21. In Situ Generated (Hypo)Iodite Catalysts for the Direct alpha-Oxyacylation of Carbonyl Compounds with Carboxylic Acids Reviewed

    Dr. Muhammet Uyanik, Daisuke Suzuki, Takeshi Yasui, Kazuaki Ishihara

    Angewandte Chemie International Edition   Vol. 50 ( 23 ) page: 5331-5334   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201101522

  22. Enantioselective Kita Oxidative Spirolactonization Catalyzed by In Situ Generated Chiral Hypervalent Iodine(III) Species Reviewed

    Muhammet Uyanik, Takeshi Yasui, Kazuaki Ishihara

    Angewandte Chemie International Edition   Vol. 49   page: 2175-2177   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.200907352

  23. Chiral Hypervalent Iodine-Catalyzed Enantioselective Oxidative Kita Spirolactonization of 1-Naphthol Derivatives and One-Pot Diastereoselective Oxidation to Epoxyspirolactones Invited Reviewed

    Muhammet Uyanik, Takeshi Yasui, Kazuaki Ishihara

    Tetrahedron   Vol. 66 ( 31 ) page: 5841-5851   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tet.2010.04.060

  24. Quaternary Ammonium (Hypo)iodite Catalysis for Enantioselective Oxidative Cycloetherification Reviewed

    Muhammet Uyanik, Hiroaki Okamoto, Takeshi Yasui, Kazuaki Ishihara

    Science   Vol. 328 ( 5984 ) page: 1376-1379   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.1188217

  25. Hypervalent Iodine-Catalyzed Oxylactonization of Ketocarboxylic Acids to Ketolactones Invited Reviewed

    Muhammet Uyanik, Takeshi Yasui, Kazuaki Ishihara

    Bioorganic & Medicinal Chemistry Letters   Vol. 19   page: 3848-3851   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmcl.2009.03.148

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MISC 1

  1. ニトロメタンから窒素原子を取りだす!?危険な反応をより安全に行える新手法 Invited

    月刊「化学」   Vol. 75 ( 5 ) page: 71 - 72   2020.5

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    Language:Japanese  

Presentations 16

  1. プロトン共役電子移動を起点としたシクロプロパノール誘導体の触媒的環拡大反応を利用するベンゼン縮環環状ケトンの合成

    菊池友宏、安井猛、山本芳彦

    日本薬学会第142年会  2022.3.28  日本薬学会

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  2. Rh触媒を用いたC-H活性化による縮環キノロン誘導体の合成

    平子直洋、安井猛、山本芳彦

    日本薬学会第142年会  2022.3.27  日本薬学会

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  3. 可視光駆動型コバルト触媒を利用した形式的1,8-アシロキシ転移を伴う1,6-ジイニルエステルのカスケード型環化反応の開発

    山田啓士、安井猛、山本芳彦

    日本薬学会第142年会  2022.3.27  日本薬学会

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  4. Enantioselective [2+2+2] Cycloaddition of Enediynes Enabled by Cobalt-Organophotoredox Cooperative Catalysis

    Takeshi Yasui, Rine Tatsumi, Yoshihiko Yamamoto

    2021.9.7 

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    Event date: 2021.9

    Presentation type:Poster presentation  

  5. コバルト/光レドックス触媒によるエステル含有1,6-ジインの環化異性化反応による1-ナフトール誘導体の合成

    山田啓士、安井猛、山本芳彦

    第67回有機金属化学討論会  2021.9.7 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Poster presentation  

  6. Pd触媒を用いた[2+2+1]スピロ環化と芳香族C-H活性化による縮環2-キノロンの合成

    平子直洋,安井猛,山本芳彦

    第67回日本薬学会東海支部大会  2021.7.3 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  7. 可視光駆動型コバルト触媒を用いるエステル含有1,6-ジインの環化異性化反応による1-ナフトール誘導体の合成

    山田啓士,巽理寧、安井猛,山本芳彦

    第67回日本薬学会東海支部大会  2021.7.3 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  8. 可視光駆動型コバルト触媒を用いるエンジインの不斉[2+2+2]環化付加反応の開発

    安井猛,巽理寧、山本芳彦

    第67回日本薬学会東海支部大会  2021.7.3 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  9. プロトン共役電子移動を利用するシクロプロパノール誘導体の触媒的環拡大反応の開発

    菊池友宏,安井猛,山本芳彦

    第67回日本薬学会東海支部大会  2021.7.3 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  10. コバルト/光レドックス触媒を利用するエステル含有1,6-ジインの環化異性化反応による1-ナフトール誘導体の合成

    山田啓士、安井猛、山本芳彦

    日本化学会第101春季年会  2021.3.19  日本化学会

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  11. ロジウム触媒を用いるシクロプロパノール含有1,6-ジインの環化異性化反応によるらせん状エキソジエン骨格の構築

    菊池友宏、安井猛、山本芳彦 2020

    日本化学会第101春季年会  2021.3.19  日本化学会

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    Event date: 2021.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  12. ロジウム触媒を用いるエンジインの[2+2+2]環化付加反応による5-6-5三環性ラクトン骨格の不斉合成

    安井猛,栗崎晃太郎、山本芳彦

    第66回有機金属化学討論会  2019.9.14 

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    Event date: 2019.9 - 0219.9

    Presentation type:Oral presentation (general)  

  13. キラルロジウム触媒を用いるエンジインの[2+2+2]環化付加反応による5-6-5三環性ラクトン骨格の不斉合成

    栗崎晃太朗、安井猛、山本芳彦

    日本化学会第99春季年会  2019.3.17 

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    Event date: 2019.3

    Presentation type:Oral presentation (general)  

  14. ロジウム触媒を用いる1,6-ジインの環化異性化反応によるらせん状エキソジエン骨格の合成

    菊池友宏、安井猛、山本芳彦

    日本化学会第99春季年会  2019.3.17 

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    Event date: 2019.3

    Presentation type:Oral presentation (general)  

  15. ロジウム触媒を用いるシクロプロパノール含有1,6-ジインの環化異性化反応によるらせん状エキソジエン骨格の合成

    菊池友宏、安井猛、山本芳彦

    日本薬学会第140年会 

  16. キラルカチオン性ロジウム触媒を用いるエンジインの不斉[2+2+2]付加環化反応の開発

    安井猛,栗崎晃太郎、山本芳彦

    日本薬学会第140年会 

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Research Project for Joint Research, Competitive Funding, etc. 1

  1. 遷移金属触媒を用いる光学活性らせん性環状エキソジエン合成法の開発

    Grant number:200052  2020.11 - 2022.11

    住友財団 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1500000 ( Direct Cost: \1500000 )

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. コバルト/光レドックス協働触媒が拓くσ結合活性化を伴う環化異性化反応

    Grant number:21K05051  2021.4 - 2024.3

    基盤研究(C)

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    Authorship:Principal investigator 

 

Teaching Experience (On-campus) 22

  1. 化学生命工学実験3

    2021

  2. 化学生命工学実験2

    2021

  3. Organic Chemistry Research Advanced Course

    2021

  4. Seminar in Organic Chemistry IIC

    2021

  5. Seminar in Organic Chemistry IIA

    2021

  6. Organic Chemistry Research Course

    2021

  7. Seminar in Organic Chemistry ⅠB

    2021

  8. Seminar in Organic Chemistry ⅠA

    2021

  9. Organic Chemistry 4 with Exercises

    2021

  10. Seminar in Organic Chemistry IIB

    2021

  11. Basic Training for Crossover Research Course

    2021

  12. Advanced Organic Chemistry

    2021

  13. Basic Training for Crossover Research

    2021

  14. Seminar in Organic Chemistry IID

    2021

  15. Organic Chemistry 4 with Exercises

    2020

  16. Organic Chemistry Research Course

    2020

  17. Seminar in Organic Chemistry ⅠB

    2020

  18. Seminar in Organic Chemistry ⅠA

    2020

  19. 化学生命工学実験3

    2020

  20. 化学生命工学実験2

    2020

  21. 創薬有機化学セミナーⅡB

    2020

  22. 創薬有機化学実習

    2020

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Social Contribution 1

  1. 愛知県立豊田西高等学校 出前講義

    Role(s):Lecturer

    愛知県立豊田西高等学校  2020.11