Updated on 2022/06/08

写真a

 
INOUE Aiko
 
Organization
Institutes of Innovation for Future Society Designated lecturer
Graduate School of Medicine Designated lecturer
Title
Designated lecturer

Degree 1

  1. 博士(医学) ( 2017.3   名古屋大学 ) 

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2017.3

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    Country: Japan

  2. Hamamatsu University School of Medicine   Graduate School, Division of Medical Sciences

    - 2003.3

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    Country: Japan

Professional Memberships 2

  1. 日本老年医学会

  2. 日本サルコペニア・フレイル学会   評議員

Committee Memberships 3

  1.   豊山町地域包括支援センター運営協議会委員  

    2121.8   

  2.   豊山町健康づくり審議会委員  

    2022.7   

  3.   豊山町総合計画審議会委員  

    2018.11   

Awards 1

  1. 第4回日本サルコペニア・フレイル学会大会最優秀演題賞

    2017.10   第4回日本サルコペニア・フレイル学会大会  

    井上愛子、成憲武、朴麗梅、五藤大貴、小笠原真雄、葛谷雅文

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

 

Papers 28

  1. Cathepsin K activity controls cachexia-induced muscle atrophy via the modulation of IRS1 ubiquitination

    Meng Xiangkun, Huang Zhe, Inoue Aiko, Wang Hailong, Wan Ying, Yue Xueling, Xu Shengnan, Jin Xueying, Shi Guo-Ping, Kuzuya Masafumi, Cheng Xian Wu

    JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE   Vol. 13 ( 2 ) page: 1197 - 1209   2022.4

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    Language:Japanese  

    DOI: 10.1002/jcsm.12919

    Web of Science

  2. Short- and long-term effects of different exercise programs on the gait performance of older adults with subjective cognitive decline: A randomized controlled trial

    Fujita Kosuke, Umegaki Hiroyuki, Makino Taeko, Uemura Kazuki, Hayashi Takahiro, Inoue Aiko, Uno Chiharu, Kitada Tomoharu, Huang Chi Hsien, Shimada Hiroyuki, Kuzuya Masafumi

    EXPERIMENTAL GERONTOLOGY   Vol. 156   2021.12

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  3. Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice

    Goto Hiroki, Inoue Aiko, Piao Limei, Hu Lina, Huang Zhe, Meng Xiangkun, Suzuki Yusuke, Umegaki Hiroyuki, Kuzuya Masafumi, Cheng Xian Wu

    STEM CELLS INTERNATIONAL   Vol. 2021   2021.11

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    Language:Japanese  

    DOI: 10.1155/2021/9202990

    Web of Science

  4. Statins Mitigate Stress-Related Vascular Aging and Atherosclerosis in apoE-Deficient Mice Fed High Fat-Diet: The Role of Glucagon-Like Peptide-1/Adiponectin Axis

    Lei Yanna, Cui Qingsong, Yang Guang, Piao Limei, Inoue Aiko, Wu Hongxian, Li Xiang, Kuzuya Masafumi, Cheng Xian Wu

    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY   Vol. 9   2021.7

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    Language:Japanese  

    DOI: 10.3389/fcell.2021.687868

    Web of Science

  5. Effect of Various Exercises on Intrinsic Capacity in Older Adults With Subjective Cognitive Concerns

    Huang Chi Hsien, Umegaki Hiroyuki, Makino Taeko, Uemura Kazuki, Hayashi Takahiro, Kitada Tomoharu, Inoue Aiko, Shimada Hiroyuki, Kuzuya Masafumi

    JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION   Vol. 22 ( 4 ) page: 780 - +   2021.4

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  6. Mental Health Status of the Older Adults in Japan During the COVID-19 Pandemic

    Fujita Kosuke, Inoue Aiko, Kuzuya Masafumi, Uno Chiharu, Huang Chi Hsien, Umegaki Hiroyuki, Onishi Joji

    JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION   Vol. 22 ( 1 ) page: 220 - 221   2021.1

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  7. Effect of various exercises on frailty among older adults with subjective cognitive concerns: a randomised controlled trial

    Huang Chi Hsien, Umegaki Hiroyuki, Makino Taeko, Uemura Kazuki, Hayashi Takahiro, Kitada Tomoharu, Inoue Aiko, Shimada Hiroyuki, Kuzuya Masafumi

    AGE AND AGEING   Vol. 49 ( 6 ) page: 1011 - 1019   2020.11

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    Language:Japanese  

    DOI: 10.1093/ageing/afaa086

    Web of Science

  8. Deficiency of cysteinyl cathepsin K suppresses the development of experimental intimal hyperplasia in response to chronic stress

    Meng Xiangkun, Piao Limei, Wang Hailong, Inoue Aiko, Huang Zhe, Jiang Haiying, Nakamura Kae, Sasaki Takeshi, Li Xiang, Xu Wenhu, Yu Chenglin, Hu Lina, Wu Hongxian, Murohara Toyoaki, Shi Guo-Ping, Kuzuya Masafumi, Cheng Xian Wu

    JOURNAL OF HYPERTENSION   Vol. 38 ( 8 ) page: 1514 - 1524   2020.8

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  9. Increased dipeptidyl peptidase-4 accelerates chronic stress-related thrombosis in a mouse carotid artery model

    Jin Xianglan, Jin Chunzi, Nakamura Kae, Jin Tiefeng, Xin Minglong, Wan Ying, Yue Xueling, Jin Shengyu, Wang Hailong, Inoue Aiko, Nan Yongshan, Lin Zhenhua, Kuzuya Masafumi, Cheng Xian Wu

    JOURNAL OF HYPERTENSION   Vol. 38 ( 8 ) page: 1504 - 1513   2020.8

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  10. Combined Impact of Physical Frailty and Social Isolation on Rate of Falls in Older Adults

    Hayashi T., Umegaki Hiroyuki, Makino T., Huang C. H., Inoue A., Shimada H., Kuzuya M.

    JOURNAL OF NUTRITION HEALTH & AGING   Vol. 24 ( 3 ) page: 312 - 318   2020.3

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    Language:Japanese  

    DOI: 10.1007/s12603-020-1316-5

    Web of Science

  11. PLF-1 (Proliferin-1) Modulates Smooth Muscle Cell Proliferation and Development of Experimental Intimal Hyperplasia

    Hu Lina, Huang Zhe, Ishii Hideki, Wu Hongxian, Suzuki Susumu, Inoue Aiko, Kim Weon, Jiang Haiying, Li Xiang, Zhu Enbo, Piao Limei, Zhao Guangxian, Lei Yanna, Okumura Kenji, Shi Guo-Ping, Murohara Toyoaki, Kuzuya Masafumi, Cheng Xian Wu

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   Vol. 8 ( 24 )   2019.12

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    Language:Japanese  

    DOI: 10.1161/JAHA.117.005886

    Web of Science

  12. Cathepsin S-Mediated Negative Regulation of Wnt5a/SC35 Activation Contributes to Ischemia-Induced Neovascularization in Aged Mice

    Xu Wenhu, Yu Chenglin, Piao Limei, Inoue Aiko, Wang Hailong, Meng Xiangkun, Li Xiang, Cui Lan, Umegaki Hiroyuki, Shi Guo-Ping, Murohara Toyoaki, Kuzuya Masafumi, Cheng Xian Wu

    CIRCULATION JOURNAL   Vol. 83 ( 12 ) page: 2537 - +   2019.12

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    Language:Japanese  

    DOI: 10.1253/circj.CJ-19-0325

    Web of Science

  13. Cathepsin S Deficiency Mitigated Chronic Stress-Related Neointimal Hyperplasia in Mice

    Wang Hailong, Meng Xiangkun, Piao Limei, Inoue Aiko, Xu Wenhu, Yu Chenglin, Nakamura Kae, Hu Lina, Sasaki Takeshi, Wu Hongxian, Unno Kazumasa, Umegaki Hiroyuki, Murohara Toyoaki, Shi Guo-Ping, Kuzuya Masafumi, Cheng Xian Wu

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   Vol. 8 ( 14 )   2019.7

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    Language:Japanese  

    DOI: 10.1161/JAHA.119.011994

    Web of Science

  14. Cathepsin S Deficiency Impaired Noevascularization in Response to Ischemia via the Activation of Wnt5-SC35 Signaling Pathway in Advanced Age

    Xu Wenhu, Yu Chenglin, Piao Limei, Inoue Aiko, Kuzuya Masafumi, Cheng Xian Wu

    CIRCULATION   Vol. 138   2018.11

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    Language:Japanese  

    Web of Science

  15. ACDF-1Modulates Smooth Muscle Cell Proliferation and Development of Experimental Intimal Hyperplasia

    Hu Lina, Ishii Hideki, Wu Hongxian, Suzuki Susumu, Inoue Aiko, Shi Guo-Ping, Murohara Toyoaki, Kuzuya Masafumi, Cheng Xian Wu

    CIRCULATION   Vol. 138   2018.11

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    Language:Japanese  

    Web of Science

  16. Adiponectin/AdipoR1 Signal Inactivation Contributes to Impaired Angiogenesis in Mice of Advanced Age

    Piao Limei, Yu Chenglin, Xu Wenhu, Inoue Aiko, Shibata Rei, Ouchi Noriyuki, Murohara Toyoaki, Kuzuya Masafumi, Cheng Xian Wu

    CIRCULATION   Vol. 138   2018.11

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    Language:Japanese  

    Web of Science

  17. Apoptotic Cell-Derived Growth Factor-1 Modulates Noevascularization in Response to Ischemia via the activation of PI3K/Akt/p38MAPK-Depended and -Independent mTOR Signaling Cascades

    Yu Chenglin, Piao Limei, Xu Wenhu, Inoue Aiko, Kuzuya Masafumi, Cheng Xian Wu

    CIRCULATION   Vol. 138   2018.11

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    Language:Japanese  

    Web of Science

  18. Cathepsin S Controls Injury-Related Neointimal Formation in Mice Under Chronic Stress via the Modulation of Inflammation and Immune Action

    Wang Hailong, Li Limei, Meng Xiangkun, Inoue Aiko, Shi Guo-Ping, Kuzuya Masafumi, Cheng Xian Wu

    CIRCULATION   Vol. 138   2018.11

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    Language:Japanese  

    Web of Science

  19. Adiponectin/AdiopR1 signal inactivation contributes to impaired angiogenesis in mice of advanced age

    Piao Limei, Yu Chenglin, Xu Wenhu, Inoue Aiko, Shibata Rei, Li Xiang, Nan Yongshan, Zhao Guangxian, Wang Hailong, Meng Xiangkun, Lei Yanna, Goto Hiroki, Ouchi Noriyuki, Murohara Toyoaki, Kuzuya Masafumi, Cheng Xian Wu

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 267   page: 150-155   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcard.2018.05.089

    Web of Science

  20. Response to letter "DPP-4 inhibition as a therapeutic strategy to ameliorate diabetic metabolic memory"

    Cheng Xian Wu, Lei Yanna, Piao Limei, Inoue Aiko, Yang Guang, Zhu Enbo, Kuzuya Masafumi

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 256   page: 17-17   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcard.2017.08.041

    Web of Science

  21. Cathepsin K activity controls cardiotoxin-induced skeletal muscle repair in mice

    Ogasawara Shinyu, Cheng Xian Wu, Inoue Aiko, Hu Lina, Piao Limei, Yu Chenglin, Goto Hiroki, Xu Wenhu, Zhao Guangxian, Lei Yanna, Yang Guang, Kimura Kaoru, Umegaki Hiroyuki, Shi Guo-Ping, Kuzuya Masafumi

    JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE   Vol. 9 ( 1 ) page: 160 - 175   2018.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcsm.12248

    Web of Science

  22. Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis

    Piao Limei, Zhao Guangxian, Zhu Enbo, Inoue Aiko, Shibata Rei, Lei Yanna, Hu Lina, Yu Chenglin, Yang Guang, Wu Hongxian, Xu Wenhu, Okumura Kenji, Ouchi Noriyuki, Murohara Toyoaki, Kuzuya Masafumi, Cheng Xian Wu

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   Vol. 6 ( 10 )   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/JAHA.117.006421

    Web of Science

  23. Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress

    Lei Yanna, Yang Guang, Hu Lina, Piao Limei, Inoue Aiko, Jiang Haiying, Sasaki Takeshi, Zhao Guangxian, Yisireyili Maimaiti, Yu Chenglin, Xu Wenhu, Takeshita Kyosuke, Okumura Kenji, Kuzuya Masafumi, Cheng Xian Wu

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 243   page: 413-420   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcard.2017.05.062

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  24. Exenatide mitigated diet-induced vascular aging and atherosclerotic plaque growth in ApoE-deficient mice under chronic stress

    Yang Guang, Lei Yanna, Inoue Aiko, Piao Limei, Hu Lina, Jiang Haiying, Sasaki Takeshi, Wu Hongxian, Xu Wenhu, Yu Chenglin, Zhao Guangxian, Ogasawara Shinyu, Okumura Kenji, Kuzuya Masafumi, Cheng Xian-Wu

    ATHEROSCLEROSIS   Vol. 264   page: 1-10   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2017.07.014

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  25. Dipeptidyl Peptidase-4 Regulates Hematopoietic Stem Cell Activation in Response to Chronic Stress

    Zhu Enbo, Hu Lina, Wu Hongxian, Piao Limei, Zhao Guangxian, Inoue Aiko, Kim Weon, Yu Chenglin, Xu Wenhu, Bando Yasuko K., Li Xiang, Lei Yanna, Hao Chang-Ning, Takeshita Kyosuke, Kim Woo-Shik, Okumura Kenji, Murohara Toyoaki, Kuzuya Masafumi, Cheng Xian Wu

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   Vol. 6 ( 7 )   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/JAHA.117.006394

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  26. Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice Reviewed

    Aiko Inoue, Xian Wu Cheng, Zhe Huang, Lina Hu, Ryosuke Kikuchi, Haiying Jiang, Limei Piao,Takeshi Sasaki, Kohji Itakura, Hongxian Wu, Guangxian Zhao, Yanna Lei, Guang Yang, Enbo Zhu, Xiang Li, Kohji Sato, Teruhiko Koike, Masafumi Kuzuya.

    Journal of Cachexia, Sarcopenia and Muscle   Vol. 8 ( 3 ) page: 370-385   2017.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcsm.12166.

    PubMed

  27. Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice

    Inoue Aiko, Cheng Xian Wu, Huang Zhe, Hu Lina, Kikuchi Ryosuke, Jiang Haiying, Piao Limei, Sasaki Takeshi, Itakura Kohji, Wu Hongxian, Zhao Guangxian, Lei Yanna, Yang Guang, Zhu Enbo, Li Xiang, Sato Kohji, Koike Teruhiko, Kuzuya Masafumi

    JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE   Vol. 8 ( 3 ) page: 370 - 385   2017.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcsm.12166

    Web of Science

  28. The Soluble VEGF Receptor sFlt-1 Contributes to Impaired Neovascularization in Aged Mice

    Zhao Guangxian, Cheng Xian W., Piao Limei, Hu Lina, Lei Yanna, Yang Guang, Inoue Aiko, Ogasawara Shinyu, Wu Hongxian, Hao Chang-Ning, Okumura Kenji, Kuzuya Masafumi

    AGING AND DISEASE   Vol. 8 ( 3 ) page: 287-300   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.14336/AD.2016.0920

    Web of Science

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. 超高齢社会における健康増進のためのICT/IoT利活用に関する研究

    Grant number:21K12593  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    浦田 真由, 安田 孝美, 井上 愛子

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    Authorship:Coinvestigator(s) 

    超高齢社会において,高齢者の社会的孤立をいかに防ぐかは自治体の大きな課題となっているが,新型コロナウイルス感染症の影響により,地域での高齢者支援サービスの実施が困難となっている。本研究では,地域在住高齢者の健康増進のためのICT/IoT利活用を社会情報学と老年医学の学際研究として取り組み,地域への実装によってその効果を検証する。健康寿命を延ばすためのモデルを構築し,地域のICT/IoT 利活用を支える担い手の育成を行うことで,研究期間後も取り組みを継続させることを目指している。

  2. 独居高齢者に対するICTを活用した包括的フレイル予防システムの運用による介入効果

    Grant number:21K17436  2021.4 - 2024.3

    科学研究費助成事業  若手研究

    井上 愛子

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    世界に類を見ないスピードで超高齢社会を迎えている我が国において、ケアが必要な高齢者の絶対数の増加と現役世代の減少により医療・介護を担う人的資源が枯渇していく中で、持続可能なフレイルへの対策が急務となっている。
    本研究では、申請者らが2019年度に構築した循環型健康寿命延伸プログラムをスマートスピーカーを活用した独居高齢者向けのフレイル予防アプリケーション(独居高齢者見守りシステム)として新たに改良し、包括的フレイル予防支援システムによる独居高齢者の心身機能の維持・向上やフレイル予防効果ならびに健康行動促進要因を明らかにする。

  3. Mechanism of skeletal muscle remodeling and regeneration for the prevention of frailty and sarcopenia

    Grant number:18K15414  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Inoue Aiko

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    Skeletal muscle in the elderly is often accompanied with damage (e.g., sarcopenia, frailty, etc.), and the approach to the skeletal muscle regeneration is necessary for the treatment. Notch-1 signaling, which plays an important role in cell differentiation, proliferation, and apoptosis, is reported to be inactivated during aging. Cathepsin K has been reported to activate Notch1. In this study, we have investigated the mechanism of sarcopenia, specially focused on cathepsin K-mediated Notch1 singling activation. We found that cathepsin K is involved in skeletal muscle disorders such as sarcopenia.