Updated on 2023/10/23

写真a

 
SUZUKI Toshihiko
 
Organization
Nagoya University Hospital Maternity and Perinatal Care Center Assistant Professor
Graduate School
Graduate School of Medicine
Title
Assistant Professor

Degree 1

  1. Ph.D. (Medicine) ( 2020.7   Nagoya University ) 

Research Areas 1

  1. Life Science / Embryonic medicine and pediatrics

Current Research Project and SDGs 1

  1. The relationship between the carbon dioxide ventilatory response (CO2 response) and apnea

Professional Memberships 3

  1. 日本周産期・新生児医学会

  2. 日本新生児成育医学会

  3. 日本小児科学会

 

Papers 10

  1. Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy

    Suzuki Toshihiko, Sato Yoshiaki, Kushida Yoshihiro, Tsuji Masahiro, Wakao Shohei, Ueda Kazuto, Imai Kenji, Iitani Yukako, Shimizu Shinobu, Hida Hideki, Temma Takashi, Saito Shigeyoshi, Iida Hidehiro, Mizuno Masaaki, Takahashi Yoshiyuki, Dezawa Mari, Borlongan Cesar V, Hayakawa Masahiro

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   Vol. 41 ( 7 ) page: 1707 - 1720   2021.7

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0271678X20972656

    Web of Science

    PubMed

  2. Mesenchymal stem/stromal cells stably transduced with an inhibitor of CC chemokine ligand 2 ameliorate bronchopulmonary dysplasia and pulmonary hypertension. Reviewed

    Suzuki T, Sato Y, Yamamoto H, Kato T, Kitase Y, Ueda K, Mimatsu H, Sugiyama Y, Onoda A, Saito S, Takahashi Y, Nakayama T, Hayakawa M

    Cytotherapy     2020.3

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    Authorship:Lead author   Language:English   Publishing type:Doctoral thesis  

    DOI: 10.1016/j.jcyt.2020.01.009

    PubMed

  3. Systemic administration of clinical-grade multilineage-differentiating stress-enduring cells ameliorates hypoxic-ischemic brain injury in neonatal rats.

    Ueda K, Sato Y, Shimizu S, Suzuki T, Onoda A, Miura R, Go S, Mimatsu H, Kitase Y, Yamashita Y, Irie K, Tsuji M, Mishima K, Mizuno M, Takahashi Y, Dezawa M, Hayakawa M

    Scientific reports   Vol. 13 ( 1 ) page: 14958   2023.9

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    Language:English   Publisher:Scientific Reports  

    Multilineage-differentiating stress-enduring (Muse) cells are endogenous reparative pluripotent stem cells present in the bone marrow, peripheral blood, and organ connective tissues. We assessed the homing and therapeutic effects of systemically administered nafimestrocel, a clinical-grade human Muse cell-based product, without immunosuppressants in a neonatal hypoxic–ischemic (HI) rat model. HI injury was induced on postnatal day 7 (P7) and was confirmed by T2-weighted magnetic resonance imaging on P10. HI rats received a single dose nafimestrocel (1 × 106 cells/body) or Hank’s balanced salt solution (vehicle group) intravenously at either three days (on P10; M3 group) or seven days (on P14; M7 group) after HI insult. Radioisotope experiment demonstrated the homing of chromium-51-labeled nafimestrocel to the both cerebral hemispheres. The cylinder test (M3 and M7 groups) and open-field test (M7 group) showed significant amelioration of paralysis and hyperactivity at five weeks of age compared with those in the vehicle group. Nafimestrocel did not cause adverse events such as death or pathological changes in the lung at ten weeks in the both groups. Nafimestrocel attenuated the production of tumor necrosis factor-α and inducible nitric oxide synthase from activated cultured microglia in vitro. These results demonstrate the potential therapeutic benefits and safety of nafimestrocel.

    DOI: 10.1038/s41598-023-41026-3

    Scopus

    PubMed

  4. Altered offspring neurodevelopment in an L-NAME-induced preeclampsia rat model.

    Nakamura N, Ushida T, Onoda A, Ueda K, Miura R, Suzuki T, Katsuki S, Mizutani H, Yoshida K, Tano S, Iitani Y, Imai K, Hayakawa M, Kajiyama H, Sato Y, Kotani T

    Frontiers in pediatrics   Vol. 11   page: 1168173   2023

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    Language:English   Publisher:Frontiers in Pediatrics  

    Introduction: To investigate the mechanism underlying the increased risk of subsequent neurodevelopmental disorders in children born to mothers with preeclampsia, we evaluated the neurodevelopment of offspring of a preeclampsia rat model induced by the administration of N-nitro-L-arginine methyl ester (L-NAME) and identified unique protein signatures in the offspring cerebrospinal fluid. Methods: Pregnant rats received an intraperitoneal injection of L-NAME (250 mg/kg/day) during gestational days 15–20 to establish a preeclampsia model. Behavioral experiments (negative geotaxis, open-field, rotarod treadmill, and active avoidance tests), immunohistochemistry [anti-neuronal nuclei (NeuN) staining in the hippocampal dentate gyrus and cerebral cortex on postnatal day 70], and proteome analysis of the cerebrospinal fluid on postnatal day 5 were performed on male offspring. Results: Offspring of the preeclampsia dam exhibited increased growth restriction at birth (52.5%), but showed postnatal catch-up growth on postnatal day 14. Several behavioral abnormalities including motor development and vestibular function (negative geotaxis test: p < 0.01) in the neonatal period; motor coordination and learning skills (rotarod treadmill test: p = 0.01); and memory skills (active avoidance test: p < 0.01) in the juvenile period were observed. NeuN-positive cells in preeclampsia rats were significantly reduced in both the hippocampal dentate gyrus and cerebral cortex (p < 0.01, p < 0.01, respectively). Among the 1270 proteins in the cerebrospinal fluid identified using liquid chromatography-tandem mass spectrometry, 32 were differentially expressed. Principal component analysis showed that most cerebrospinal fluid samples achieved clear separation between preeclampsia and control rats. Pathway analysis revealed that differentially expressed proteins were associated with endoplasmic reticulum translocation, Rab proteins, and ribosomal proteins, which are involved in various nervous system disorders including autism spectrum disorders, schizophrenia, and Alzheimer's disease. Conclusion: The offspring of the L-NAME-induced preeclampsia model rats exhibited key features of neurodevelopmental abnormalities on behavioral and pathological examinations similar to humans. We found altered cerebrospinal fluid protein profiling in this preeclampsia rat, and the unique protein signatures related to endoplasmic reticulum translocation, Rab proteins, and ribosomal proteins may be associated with subsequent adverse neurodevelopment in the offspring.

    DOI: 10.3389/fped.2023.1168173

    Web of Science

    Scopus

    PubMed

  5. Establishment of a Novel Fetal Growth Restriction Model and Development of a Stem-Cell Therapy Using Umbilical Cord-Derived Mesenchymal Stromal Cells Reviewed

    Front Cell Neurosci     2022.7

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    Language:English  

    DOI: 10.3389/fncel.2020.00212

  6. Safety and tolerability of a multilineage-differentiating stress-enduring cell-based product in neonatal hypoxic-ischaemic encephalopathy with therapeutic hypothermia (SHIELD trial): a clinical trial protocol open-label, non-randomised, dose-escalation trial. Reviewed

    BMJ Open     2022.4

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    Language:English  

    DOI: 10.1136/bmjopen-2021-057073

  7. A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats

    Kitase Yuma, Sato Yoshiaki, Ueda Kazuto, Suzuki Toshihiko, Mikrogeorgiou Alkisti, Sugiyama Yuichiro, Matsubara Kohki, Okabe Yuka Tsukagoshi, Shimizu Shinobu, Hirata Hitoshi, Yukawa Hiroshi, Baba Yoshinobu, Tsuji Masahiro, Takahashi Yoshiyuki, Yamamoto Akihito, Hayakawa Masahiro

    STEM CELLS AND DEVELOPMENT   Vol. 29 ( 2 ) page: 63 - 74   2020.1

  8. Administration of Bone Marrow-Derived Mononuclear Cells Contributed to the Reduction of Hypoxic-lschemic Brain Injury in Neonatal Rats

    Sato Yoshiaki, Ueda Kazuto, Kondo Taiki, Hattori Tetsuo, Mikrogeorgiou Alkisti, Sugiyama Yuichiro, Suzuki Toshihiko, Yamamoto Michiro, Hirata Hitoshi, Hirakawa Akihiro, Nakanishi Keiko, Tsuji Masahiro, Hayakawa Masahiro

    FRONTIERS IN NEUROLOGY   Vol. 9   page: 987   2018.11

  9. Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cell, but not Adipose Tissue-Derived Stem Cell, Ameliorated the Neonatal Hypoxic-Ischemic Brain Injury by Changing Cerebral Inflammatory State in Rat

    Sugiyama Yuichiro, Sato Yoshiaki, Kitase Yuma, Suzuki Toshihiko, Kondo Taiki, Mikrogeorgiou Alkisti, Horinouchi Asuka, Maruyama Shoichi, Shimoyama Yoshie, Tsuji Masahiro, Suzuki Satoshi, Yamamoto Tokunori, Hayakawa Masahiro

    FRONTIERS IN NEUROLOGY   Vol. 9   page: 757   2018.9

  10. 脳室周囲白質軟化症の重症度と拡散テンソル画像によるFA値との関係 Reviewed

    鈴木俊彦,城所博之, 久保田哲夫, 夏目淳, 根来民子

    脳と発達   Vol. 45 ( 1 ) page: 21-25   2013.1

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

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MISC 3

  1. 【小児科学レビュー-最新主要文献とガイドライン-】新生児疾患 慢性肺疾患(総説)

    鈴木俊彦

    小児科臨床   Vol. 76 ( 2 ) page: 29 - 34   2023.2

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  2. 【在胎22~23週の超早産をめぐる課題と展望】NICU入院中の合併症と予防戦略 合併症の対応と予防戦略 慢性肺疾患

    鈴木俊彦

    周産期医学   Vol. 51 ( 8 ) page: 1146 - 1150   2021.8

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  3. 【サクッとチェック NICUからの退院&在宅医療支援 サポート制度のポイントガイド】在宅人工呼吸管理が必要なケース

    鈴木俊彦

    with NEO   Vol. 33 ( 6 ) page: 907 - 911   2020.12

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

Presentations 6

  1. Intravenously transplanted Multilineage-differentiating stress enduring cells as a novel source for cell therapy to target neonatal hypoxic ischemic encephalopathy Invited International conference

    The 4th Taiwan-Korea-Japan Joint Congress on Neonatology  2022.3.19 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  2. A novel treatment for perinatal hypoxic ischemic encephalopathy using Multilineage-differentiating stress enduring cells. Invited International conference

    Toshihiko Suzuki, Yoshiaki Sato,et al.

    Pediatric Academic Societies Meeting 2018 

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    Event date: 2018.5

    Language:English   Presentation type:Poster presentation  

    Country:Canada  

  3. 新生児呼吸管理の新たな治療選択肢~SNIPPV活用術:当院における使用経験を通して~

    鈴木俊彦

    第66回日本新生児成育医学会学術集会  2022.11.26  長谷川久弥

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    Event date: 2022.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:パシフィコ横浜  

  4. 新生児慢性肺疾患に伴う肺高血圧症に対するMultilineage-differentiating stress enduring cellsを用いた治療効果の検討

    佐藤義朗、上田一仁、田中雅人、田中亮 三浦良介、呉尚治、浅田英之、北瀬悠磨、立花貴史、見松はるか、伊藤美春、齊藤明子、村松友佳子、早川昌弘

    成育医学会学術集会 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:埼玉   Country:Japan  

  5. Multilineage-differentiating stress enduring cellsを用いた 新生児低酸素性虚血性脳症に対する 治療効果の検討

    佐藤義朗、呉尚治、上田一仁、 見松はるか、北瀬悠磨、杉山裕一朗1、近藤大貴、中西圭子、辻雅弘、早川昌弘

    成育医学会学術集会 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:埼玉   Country:Japan  

  6. Mesenchymal stem cells stably transduced with a dominant-negative inhibitor of CCL2 ameliorate chronic lung disease and pulmonary hypertension. International conference

    Yoshiaki Sato , Taichi Kato, Kazuto Ueda, Mimatsu Haruka, Yuma Kitase, Alkisti Mikrogeorgiou, Yuichiro Sugiyama, Shigeki Saito, Takayuki Nakamura, Masahiro Hayakawa

    International Society for Stem Cell Research annual meeting 2017. 

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    Event date: 2017.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Boston, USA   Country:United States  

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. 脳性麻痺に対する脱落乳歯歯髄幹細胞(SHED)を用いた遠隔期細胞療法の開発

    Grant number:23K07248  2023.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    周産期・新生児医療の現場では、周産期脳障害に伴う脳性麻痺などの神経発達障害が問題視されている。根本的な治療法は未確立のため新規治療法の開発は喫緊の課題であるが、中でも幹細胞治療は1つの解決策と考えられている。そのため我々の研究グループでは、採取、培養が容易な脱落乳歯歯髄幹細胞(SHED)に着目し、これまでにSHEDの急性期投与が周産期脳障害モデルに対し有効であることを証明してきた。
    一方、脳性麻痺は主に遠隔期に発症することから、脳性麻痺の症状を確認してからでも十分効果をもたらす治療法開発も必要である。
    そこで本研究では、SHEDを用いて遠隔期の神経障害発症後に効果を示す新規細胞療法の開発を行う。

  2. 妊娠高血圧症候群に起因するSGAの慢性肺疾患の重症化機序解明と新規治療法開発

    Grant number: 19K08341  2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

    Grant amount:\4290000

  3. Muse細胞を用いた周産期脳障害の新規治療開発

    Grant number:26860844  2014.4 - 2017.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

    Grant amount:\3770000

Industrial property rights 1

  1. 多能性幹細胞による周産期脳障害の改善及び治療

    佐藤義朗、鈴木俊彦、清水忍、水野正明、早川昌弘、出澤真理

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    Applicant:佐藤義朗、鈴木俊彦、清水忍、水野正明、早川昌弘、出澤真理

    Application no:2016-098186  Date applied:2016.5

    Country of applicant:Domestic  

    Multilineage-differentiating Stress Enduring(Muse)細胞は、多能性を有し直接的に分化転換・組織修復を行うことができる間葉系幹細胞の数%を構成する細胞である。我々はHIEモデル動物で、Muse細胞が脳へ生着すること、並びに行動学的に学習及び運動障害の改善効果があることを確認した。現在HIEの治療法は、効果が限定的な低体温療法しかなく、新規治療法の開発が喫緊の課題とされている。本研究でMuse細胞を用いたHIEの新規治療法の開発を行うことにより、神経学的予後を改善する効果が期待できる。

 

Teaching Experience (On-campus) 1

  1. PBLチュートリアル

    2022

     詳細を見る

    発熱を題材としたPBLチュートリアルに関して、まとめ・総括を実施した。