Updated on 2026/07/28

写真a

 
ONOE Shunsuke
 
Organization
Nagoya University Hospital Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 1

  1. 博士(医学) ( 2014.3   名古屋大学 ) 

Research History 11

  1. Nagoya University   Nagoya University Hospital   Lecturer

    2023.12

  2. Nagoya University   Lecturer

    2023.6 - 2023.11

  3. Nagoya University   Lecturer of hospital

    2021.11 - 2023.5

  4. 名古屋大学医学部附属病院   消化器外科1   助教

    2018.10 - 2021.10

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    Country:Japan

  5. 名古屋大学医学部附属病院   消化器外科1   病院助教

    2017.4 - 2018.9

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    Country:Japan

  6. 大垣市民病院   外科   医長

    2013.10 - 2017.3

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    Country:Japan

  7. 名古屋大学医学部附属病院   消化器外科1   医員

    2011.4 - 2013.9

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    Country:Japan

  8. 国立がんセンター中央病院   外科レジデント

    2008.4 - 2011.3

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    Country:Japan

  9. 医療法人 山下病院   消化器外科

    2006.4 - 2008.3

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    Country:Japan

  10. 豊橋市民病院   一般外科   医員

    2003.7 - 2006.3

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    Country:Japan

  11. 豊橋市民病院   研修医

    2002.5 - 2003.6

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2014.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 2002.3

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    Country: Japan

Professional Memberships 3

  1. 日本外科学会

  2. 日本消化器外科学会

  3. 日本肝胆膵外科学会

 

Papers 117

  1. The impact of preoperative histological and serum biochemical factors on the early recurrence of patients undergoing surgery for retroperitoneal liposarcoma. Open Access

    Sunagawa M, Yokoyama Y, Kokuryo T, Mizuno T, Onoe S, Watanabe N, Baba T, Yamada M, Kawakatsu S, Ebata T

    Surgical oncology   Vol. 67   page: 102496   2026.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.suronc.2026.102496

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  2. Radial Margin Distance in Perihilar Cholangiocarcinoma: Defining Dual Cutoff Values of 0 and 1 mm.

    Yamamoto R, Onoe S, Mizuno T, Watanabe N, Kawakatsu S, Sunagawa M, Ogura A, Baba T, Yamada M, Shimoyama Y, Karube K, Imaizumi T, Emoto R, Ebata T

    Annals of surgery     2026.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/SLA.0000000000007138

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  3. Effectiveness of a multi-surgical department online recruitment event 'GEKA-Navi' on career motivation and residency entry: a 5-year experience Open Access

    Nakamura, S; Takami, H; Onoe, S; Baba, T; Fujii, T; Makita, S; Masano, Y; Ikeda, S; Takeuchi, D; Chen-Yoshikawa, TF

    SURGERY TODAY     2026.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-026-03362-5

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  4. [FGFR2 Fusion Gene-Positive Solid Tumors].

    Kokuryo T, Mizuno T, Onoe S, Sunagawa M, Watanabe N, Baba T, Yamada M, Kurimoto K, Kawakatsu S, Ebata T

    Gan to kagaku ryoho. Cancer & chemotherapy   Vol. 53 ( 5 ) page: 327 - 331   2026.5

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  5. Differences in Right Hepatic Duct Length Among Left-Sided Hepatectomies: Conventional Hepatectomy Versus Extended Hepatectomy Versus Trisectionectomy Open Access

    Sugiura, K; Yamada, M; Mizuno, T; Onoe, S; Watanabe, N; Kawakatsu, S; Yamaguchi, J; Sunagawa, M; Baba, T; Ebata, T

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 33 ( 5 ) page: 361 - 370   2026.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jhbp.70097

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  6. Gene profiling using whole genome analysis of bile tract cancer and its association with clinical factors

    Kokuryo, T; Sunagawa, M; Yamaguchi, J; Baba, T; Mizuno, T; Onoe, S; Watanabe, N; Yamada, M; Kawakatsu, S; Ebata, T

    CANCER RESEARCH   Vol. 86 ( 7 )   2026.4

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    DOI: 10.1158/1538-7445.AM2026-3254

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  7. KRAS mutations disrupt interactions between CD8<SUP>+</SUP> T cells and antigen-presenting cells in the tumor microenvironment of biliary tract cancer Open Access

    Terasaki, F; Kumagai, S; Fukuda, A; Tanaka, Y; Irie, T; Ito, S; Yamada, M; Onoe, S; Mizuno, T; Kokuryo, T; Koyama, S; Karube, K; Nishikawa, H; Ebata, T

    INTERNATIONAL IMMUNOLOGY   Vol. 38 ( 4 ) page: 236 - 250   2026.4

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    DOI: 10.1093/intimm/dxaf065

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  8. Influence of the Functional Reserve of the Remnant Liver on Major Hepatectomy Combined With Pancreatoduodenectomy Open Access

    Mizuno, T; Onoe, S; Watanabe, N; Yamada, M; Kawakatsu, S; Yamaguchi, J; Sunagawa, M; Baba, T; Ebata, T

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 33 ( 2 ) page: 94 - 103   2026.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jhbp.70026

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  9. A phase II study of re-introduction of gemcitabine plus cisplatin in combination with durvalumab after durvalumab maintenance therapy in patients with unresectable or recurrent biliary tract cancer (PRIDE study). Open Access

    Takeda, H; Umemoto, K; Takada, R; Satake, T; Onoe, S; Shimizu, S; Nakase, H; Hirata, K; Shioji, K; Matsumoto, K; Hata, A; Tanabe, K; Ueno, M; Furuse, J; Sunakawa, Y

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 44 ( 2_SUPPL ) page: TPS609 - TPS609   2026.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1200/JCO.2026.44.2_suppl.TPS609

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  10. Association of Preoperative Gut Microbiota Disturbances with Postoperative Infectious Complications in Major Gastrointestinal Cancer Surgery: A Large-Scale Exploratory Study Open Access

    Sugimoto, T; Yokoyama, Y; Kado, Y; Yamamoto, S; Mizuno, T; Yamaguchi, J; Onoe, S; Ebata, T; Asahara, T

    ANNALS OF SURGICAL ONCOLOGY   Vol. 33 ( 1 ) page: 224 - 234   2026.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-025-18298-2

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  11. ASO Visual Abstract: Association of Preoperative Gut Microbiota Disturbances with Postoperative Infectious Complications in Major Gastrointestinal Cancer Surgery-A Large-scale Exploratory Study

    Sugimoto, T; Yokoyama, Y; Kado, Y; Yamamoto, S; Mizuno, T; Yamaguchi, J; Onoe, S; Ebata, T; Asahara, T

    ANNALS OF SURGICAL ONCOLOGY   Vol. 33 ( 1 ) page: 327 - 328   2026.1

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    DOI: 10.1245/s10434-025-18493-1

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  12. ASO Author Reflections: Preoperative Gut Microbiota Disturbance in Gastrointestinal Cancer Surgery is Associated with Postoperative Infectious Complications

    Sugimoto, T; Yokoyama, Y; Kado, Y; Yamamoto, S; Mizuno, T; Yamaguchi, J; Onoe, S; Ebata, T; Asahara, T

    ANNALS OF SURGICAL ONCOLOGY   Vol. 33 ( 1 ) page: 311 - 312   2026.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-025-18453-9

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  13. [Surgical treatment for biliary tract cancer:up-to-date overview]. Open Access

    Onoe S, Mizuno T, Ebata T

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   Vol. 123 ( 4 ) page: 246 - 254   2026

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11405/nisshoshi.123.246

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  14. FAM111B Suppression Enhances Sensitivity to Gemcitabine in Pancreatic Cancer Through Intracellular pH Regulation Open Access

    Nishimura, M; Sunagawa, M; Kokuryo, T; Yamaguchi, J; Baba, T; Mizuno, T; Onoe, S; Watanabe, N; Kawakatsu, S; Ebata, T

    CANCER SCIENCE   Vol. 116 ( 12 ) page: 3519 - 3531   2025.12

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    DOI: 10.1111/cas.70212

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  15. Adipose-derived Stem Cell Sheets Induce Angiogenesis and Hepatic Stellate Cell Activation Open Access

    Watanabe, Y; Kokuryo, T; Onoe, S; Yamaguchi, J; Sunagawa, M; Baba, T; Kawakatsu, S; Watanabe, N; Mizuno, T; Ebata, T

    IN VIVO   Vol. 39 ( 6 ) page: 3106 - 3115   2025.11

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    DOI: 10.21873/invivo.14112

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  16. Prognostic Impact of HER2 Overexpression in Intraductal Papillary Neoplasm of the Bile Duct Open Access

    Onoe, S; Mizuno, T; Watanabe, N; Kawakatsu, S; Yamaguchi, J; Baba, T; Yamamoto, R; Shimoyama, Y; Kokuryo, T; Ebata, T

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 32 ( 11 ) page: 838 - 846   2025.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jhbp.70000

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  17. Close correlation between patients' positive mood and postoperative complication burden in hepato-biliary-pancreatic cancer: a prospective comparative cohort trial Open Access

    Onoe, S; Yokoyama, Y; Igami, T; Yamaguchi, J; Mizuno, T; Inokawa, Y; Takami, H; Sunagawa, M; Watanabe, N; Kawakatsu, S; Tokura, T; Imaizumi, T; Ebata, T

    HPB   Vol. 27 ( 11 ) page: 1390 - 1399   2025.11

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    DOI: 10.1016/j.hpb.2025.07.015

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  18. Tumor Serosal Invasion in Perihilar Cholangiocarcinoma: A Lethal But Overlooked Feature. Open Access

    Yamamoto R, Mizuno T, Onoe S, Watanabe N, Kawakatsu S, Sunagawa M, Yamaguchi J, Ogura A, Baba T, Yamada M, Shimoyama Y, Karube K, Imaizumi T, Ebata T

    Annals of surgery     2025.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/SLA.0000000000006957

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  19. The Impact of Adjuvant Chemotherapy in Patients With Locally Advanced Rectal Cancer After NeoadjuvantChemotherapy: A Propensity Score Matching Cohort Study Open Access

    Fukata, K; Ogura, A; Murata, Y; Kobayashi, R; Kawakatsu, S; Sugita, S; Onoe, S; Miyata, K; Yamaguchi, J; Mizuno, T; Ebata, T

    ANTICANCER RESEARCH   Vol. 45 ( 10 ) page: 4431 - 4439   2025.10

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    DOI: 10.21873/anticanres.1779

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  20. Dedifferentiation-Dependent Regeneration of the Biliary Ductal Epithelium in Response to Hepatic Injury in TFF1-Deficient Mice Open Access

    Yamamoto, T; Yamaguchi, J; Kokuryo, T; Yokoyama, Y; Mizuno, T; Onoe, S; Sunagawa, M; Baba, T; Ebata, T

    CELLS   Vol. 14 ( 17 )   2025.8

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    DOI: 10.3390/cells14171323

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  21. Clinical and Medical Economic Value of Screening Colonoscopy before Laparoscopic Cholecystectomy Open Access

    Igami, T; Nakamura, M; Ishikawa, T; Yamamura, T; Yamao, K; Maeda, K; Mizutani, Y; Sawada, T; Yokoyama, Y; Mizuno, T; Yamaguchi, J; Onoe, S; Sunagawa, M; Watanabe, N; Baba, T; Kawakatsu, S; Kawashima, H; Ebata, T

    MEDICAL PRINCIPLES AND PRACTICE   Vol. 34 ( 4 ) page: 369 - 378   2025.8

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    DOI: 10.1159/000545322

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  22. Delayed Laparoscopic Cholecystectomy With Fluorescent Cholangiography for Acute Cholecystitis: Is It Safe? Open Access

    Igami, T; Ishikawa, T; Yamao, K; Mizutani, Y; Yokoyama, Y; Mizuno, T; Yamaguchi, J; Onoe, S; Sunagawa, M; Watanabe, N; Kawakatsu, S; Kawashima, H; Ebata, T

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   Vol. 18 ( 1 ) page: e70092   2025.6

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    DOI: 10.1111/ases.70092

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  23. Durvalumab-combined chemotherapy for biliary tract cancer in a Japanese expert center: initial 50 cases in daily practice Open Access

    Inokawa, Y; Onoe, S; Kawakatsu, S; Hayashi, M; Watanabe, N; Maeda, O; Mizuno, T; Takami, H; Kawashima, H; Ando, Y; Ebata, T

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 87 ( 2 ) page: 254 - 263   2025.5

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    DOI: 10.18999/nagjms.87.2.254

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  24. Effect of Preoperative Autologous Blood Storage in Major Hepatectomy for Perihilar Malignancy Open Access

    Onoe, S; Yokoyama, Y; Igami, T; Yamaguchi, J; Mizuno, T; Sunagawa, M; Watanabe, N; Kawakatsu, S; Ando, M; Nagino, M; Ebata, T

    ANNALS OF SURGERY   Vol. 281 ( 5 ) page: 741 - 747   2025.5

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    DOI: 10.1097/SLA.0000000000006547

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  25. Prognostic impact of preoperative cachexia in patients undergoing major hepatopancreatobiliary surgery for malignancy Open Access

    Fugane, Y; Tanaka, S; Mizuno, Y; Nakajima, H; Yamamoto, H; Inoue, T; Nagaya, M; Nishida, Y; Onoe, S; Yamaguchi, J; Mizuno, T; Yokoyama, Y; Ebata, T

    CLINICAL NUTRITION   Vol. 47   page: 112 - 118   2025.4

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    DOI: 10.1016/j.clnu.2025.02.014

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  26. Accumulating Genetic Mutations from Primary to Secondary Biliary Tract Cancers: Analysis of Four Patients With Metachronous Biliary Tract Cancer Using Comprehensive Genomic Profiling Open Access

    Kokuryo, T; Koike, Y; Yamaguchi, J; Sunagawa, M; Baba, T; Watanabe, N; Onoe, S; Mizuno, T; Ebata, T

    CANCER GENOMICS & PROTEOMICS   Vol. 22 ( 2 ) page: 346 - 353   2025.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/cgp.20505

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  27. Reappraisal of carcinoma <i>in situ</i> residue at the bile duct margin: a single-center review of 681 patients with perihilar cholangiocarcinoma Open Access

    Yamamoto, R; Onoe, S; Mizuno, T; Watanabe, N; Kawakatsu, S; Sunagawa, M; Yamaguchi, J; Ogura, A; Baba, T; Igami, T; Yamada, M; Shimoyama, Y; Ebata, T

    HPB   Vol. 27 ( 3 ) page: 362 - 370   2025.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.hpb.2024.12.005

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  28. New Tumor Classification Using Invasion Depth in Biliary Tract Cancer Around the Cystic Duct Junction.

    Ushida Y, Watanabe N, Kawakatsu S, Yamamoto R, Mizuno T, Onoe S, Yokoyama Y, Kokuryo T, Igami T, Yamaguchi J, Sunagawa M, Baba T, Shimoyama Y, Ebata T

    Annals of surgery     2025.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/SLA.0000000000006672

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  29. TLK1 inhibition enhances the anticancer effect of deep UV irradiation

    Kokuryo, T; Koike, Y; Yamaguchi, J; Sunagawa, M; Ogura, A; Watanabe, N; Onoe, S; Miyata, K; Mizuno, T; Uehara, K; Igami, T; Yokoyama, Y; Ebata, T; Nagino, M

    CANCER SCIENCE   Vol. 116   page: 445 - 445   2025.1

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  30. Whole-genome Sequencing Analysis of Bile Tract Cancer Reveals Mutation Characteristics and Potential Biomarkers Open Access

    Kokuryo, T; Sunagawa, M; Yamaguchi, J; Baba, T; Kawakatsu, S; Watanabe, N; Onoe, S; Mizuno, T; Ebata, T

    CANCER GENOMICS & PROTEOMICS   Vol. 22 ( 1 ) page: 34 - 40   2025.1

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    DOI: 10.21873/cgp.20484

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  31. Pathological Complete Response after Pembrolizumab Treatment for Unresectable Perihilar Cholangiocarcinoma with High Microsatellite Instability: A Case Report Open Access

    Inokawa, Y; Mizuno, H; Yamada, M; Kawakatsu, S; Watanabe, N; Onoe, S; Mizuno, T; Okayama, K; Okumura, F; Kajikawa, M; Ebata, T

    SURGICAL CASE REPORTS   Vol. 11 ( 1 )   2025

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    DOI: 10.70352/scrj.cr.25-0025

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  32. Application of fluorescent cholangiography to complex biliary variants of the confluence of the cystic duct and the infraportal type of the left lateral bile duct during single-incision laparoscopic cholecystectomy: A case report Open Access

    Nishino, S; Igami, T; Yokoyama, Y; Mizuno, T; Yamaguchi, J; Onoe, S; Sunagawa, M; Watanabe, N; Baba, T; Kawakatsu, S; Ebata, T

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   Vol. 18 ( 1 ) page: e13404   2024.11

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    DOI: 10.1111/ases.13404

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  33. A clinical assessment of three-dimensional-printed liver model navigation for thrice or more repeated hepatectomy based on a conversation analysis Open Access

    Igami, T; Maehigashi, A; Nakamura, Y; Hayashi, Y; Oda, M; Yokoyama, Y; Mizuno, T; Yamaguchi, J; Onoe, S; Sunagawa, M; Watanabe, N; Baba, T; Kawakatsu, S; Mori, K; Miwa, K; Ebata, T

    SURGERY TODAY   Vol. 54 ( 10 ) page: 1238 - 1247   2024.10

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    DOI: 10.1007/s00595-024-02835-9

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  34. Risk factors for recurrent biliary obstruction following suprapapillary placement of a plastic stent as preoperative biliary drainage for perihilar biliary malignancy Open Access

    Kataoka, K; Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Uetsuki, K; Onoe, S; Mizuno, T; Ebata, T; Kawashima, H

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 31 ( 10 ) page: 726 - 736   2024.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jhbp.12043

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  35. Factors Affecting Nonfunctioning Small Pancreatic Neuroendocrine Neoplasms and Proposed New Treatment Strategies Open Access

    Hijioka, S; Yamashige, D; Esaki, M; Honda, G; Higuchi, R; Masui, T; Shimizu, Y; Ohtsuka, M; Kumamoto, Y; Katanuma, A; Gotohda, N; Akita, H; Unno, M; Endo, I; Yokoyama, Y; Yamada, S; Matsumoto, I; Ohtsuka, T; Hirano, S; Yasuda, H; Kawai, M; Aoki, T; Nakamura, M; Hashimoto, D; Rikiyama, T; Horiguchi, A; Fujii, T; Mizuno, S; Hanada, K; Tani, M; Hatori, T; Ito, T; Okuno, M; Kagawa, S; Tajima, H; Ishii, T; Sugimoto, M; Onoe, S; Takami, H; Takada, R; Miura, T; Kurita, Y; Kamei, K; Mataki, Y; Okazaki, K; Takeyama, Y; Yamaue, H; Satoi, S

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   Vol. 22 ( 7 ) page: 1416 - 1426   2024.7

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    DOI: 10.1016/j.cgh.2024.03.029

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  36. TLK1 Inhibition Enhances the Anticancer Effect of Deep UV Irradiation Through CHK1 Activation Open Access

    Koike, Y; Kokuryo, T; Yamaguchi, J; Sunagawa, M; Ogura, A; Watanabe, N; Onoe, S; Miyata, K; Mizuno, T; Uehara, K; Igami, T; Yokoyama, Y; Ebata, T; Nagino, M

    ANTICANCER RESEARCH   Vol. 44 ( 7 ) page: 2827 - 2836   2024.7

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    DOI: 10.21873/anticanres.17095

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  37. Trefoil factor 1 suppresses stemness and enhances chemosensitivity of pancreatic cancer Open Access

    Yamaguchi, J; Kokuryo, T; Yokoyama, Y; Oishi, S; Sunagawa, M; Mizuno, T; Onoe, S; Watanabe, N; Ogura, A; Ebata, T

    CANCER MEDICINE   Vol. 13 ( 11 ) page: e7395   2024.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cam4.7395

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  38. Intraductal papillary neoplasms of the bile ducts: a comparative study of a rare disease in Europe and Nagoya, Japan Open Access

    Lluis, N; Onoe, S; Serradilla-Martin, M; Achalandabaso, M; Mizuno, T; Jehaes, F; Dasari, BVM; Mambrilla-Herrero, S; Sparrelid, E; Balakrishnan, A; Hoogwater, FJH; Amaral, MJ; Andersson, B; Berrevoet, F; Doussot, A; López-López, V; Detry, O; Pozo, CDD; Machairas, N; Pekli, D; Alcázar-López, CF; Asbun, H; Bjoernsson, B; Christophides, T; Diez-Caballero, A; Francart, D; Noel, CB; Sousa-Silva, D; Toledo-Martínez, E; Tzimas, GN; Yaqub, S; Yamaguchi, J; Dokmak, S; Prieto-Calvo, M; D'Souza, MA; Spiers, HVM; Heuvel, MCV; Charco, R; Lesurtel, M; Ebata, T; Ramia, JM

    HPB   Vol. 26 ( 4 ) page: 565 - 575   2024.4

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    DOI: 10.1016/j.hpb.2024.01.009

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  39. Utility of modified pancreaticoduodenectomy (Hi-cut PD) for middle-third cholangiocarcinoma: an alternative to hepatopancreaticoduodenectomy Open Access

    Onoe, S; Mizuno, T; Watanabe, N; Yokoyama, Y; Igami, T; Yamaguchi, J; Sunagawa, M; Kawakatsu, S; Shimoyama, Y; Ebata, T

    HPB   Vol. 26 ( 4 ) page: 530 - 540   2024.4

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    DOI: 10.1016/j.hpb.2023.12.008

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  40. Liver remnant volume to body weight ratio of 0.65% as a lower limit in right hepatic trisectionectomy with bile duct resection Open Access

    Hayashi, D; Mizuno, T; Kawakatsu, S; Baba, T; Sando, M; Yamaguchi, J; Onoe, S; Watanabe, N; Sunagawa, M; Ebata, T

    SURGERY   Vol. 175 ( 2 ) page: 404 - 412   2024.2

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  41. The Goal of Intraoperative Blood Loss in Major Hepatobiliary Resection for Perihilar Cholangiocarcinoma Saving Patients From a Heavy Complication Burden Open Access

    Kawakatsu, S; Mizuno, T; Yamaguchi, J; Watanabe, N; Onoe, S; Sunagawa, M; Baba, T; Igami, T; Yokoyama, Y; Imaizumi, T; Ebata, T

    ANNALS OF SURGERY   Vol. 278 ( 5 ) page: E1035 - E1040   2023.11

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    DOI: 10.1097/SLA.0000000000005869

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  42. Two-step arterial reconstruction technique for <i>en bloc</i> resection of a large retroperitoneal liposarcoma involving the common iliac artery Open Access

    Sunagawa, M; Yokoyama, Y; Banno, H; Sugimoto, M; Mizuno, T; Yamaguchi, J; Onoe, S; Watanabe, N; Kawakatsu, S; Ebata, T

    SURGERY TODAY   Vol. 53 ( 11 ) page: 1320 - 1324   2023.11

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    DOI: 10.1007/s00595-023-02684-y

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  43. Clinical value of fluorescent cholangiography for the infraportal type of right posterior bile duct Open Access

    Igami, T; Asai, Y; Minami, T; Seita, K; Yokoyama, Y; Mizuno, T; Yamaguchi, J; Onoe, S; Watanabe, N; Ebata, T

    MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES   Vol. 32 ( 5 ) page: 256 - 263   2023.10

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    DOI: 10.1080/13645706.2023.2217915

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  44. Standard versus delayed initiation of S-1 adjuvant chemotherapy after surgery for pancreatic cancer: a secondary analysis of a nationwide cohort by the Japan Pancreas Society Open Access

    Tomimaru, Y; Eguchi, H; Shimomura, Y; Kitamura, T; Inoue, Y; Nagakawa, Y; Ohba, A; Onoe, S; Unno, M; Hashimoto, D; Kawakatsu, S; Hayashi, T; Higuchi, R; Kitagawa, H; Uemura, K; Kimura, Y; Satoi, S; Takeyama, Y; Comm of Clin Res; Japan Pancreas Soc

    JOURNAL OF GASTROENTEROLOGY   Vol. 58 ( 8 ) page: 790 - 799   2023.8

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    DOI: 10.1007/s00535-023-01988-7

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  45. Is a specific T classification needed for extrahepatic intraductal papillary neoplasm of the bile duct (IPNB) type 2 associated with invasive carcinoma?

    Mitake, Y; Onoe, S; Igami, T; Mizuno, T; Yamaguchi, J; Sunagawa, M; Watanabe, N; Kawakatsu, S; Shimoyama, Y; Ebata, T

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 30 ( 6 ) page: 745 - 754   2023.6

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  46. Impact of skeletal muscle mass on the prognosis of patients undergoing neoadjuvant chemotherapy for resectable or borderline resectable pancreatic cancer Open Access

    Nakajima, H; Yamaguchi, J; Takami, H; Hayashi, M; Kodera, Y; Nishida, Y; Watanabe, N; Onoe, S; Mizuno, T; Yokoyama, Y; Ebata, T

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 28 ( 5 ) page: 688 - 697   2023.5

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    DOI: 10.1007/s10147-023-02321-1

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  47. Cyclodextrin Conjugated α-Bisabolol Suppresses FAK Phosphorylation and Induces Apoptosis in Pancreatic Cancer Open Access

    Kano, MT; Kokuryo, TOSHIO; Baba, TAISUKE; Yamazaki, KIMITOSHI; Yamaguchi, J; Sunagawa, M; Ogura, A; Watanabe, N; Onoe, S; Miyata, K; Mizuno, T; Uehara, K; Igami, T; Yokoyama, Y; Ebata, T; Nagino, M

    ANTICANCER RESEARCH   Vol. 43 ( 3 ) page: 1009 - 1016   2023.3

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    DOI: 10.21873/anticanres.16245

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  48. Which modality is better to diagnose high-grade transformation in retroperitoneal liposarcoma? Comparison of computed tomography, positron emission tomography, and magnetic resonance imaging Open Access

    Nakashima, Y; Yokoyama, Y; Ogawa, H; Sakakibara, A; Sunagawa, M; Nishida, Y; Mizuno, T; Yamaguchi, J; Onoe, S; Watanabe, N; Kawakatsu, S; Igami, T; Ebata, T

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 28 ( 3 ) page: 482 - 490   2023.3

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    DOI: 10.1007/s10147-022-02287-6

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  49. Efficacy of Extended Modification in Left Hemihepatectomy for Advanced Perihilar Cholangiocarcinoma <i>Comparison Between H12345</i>′<i>8</i>′-<i>B</i>-<i>MHV and H1234</i>-<i>B</i> Open Access

    Otsuka, S; Mizuno, T; Yamaguchi, J; Onoe, S; Watanabe, N; Shimoyama, Y; Igami, T; Uehara, K; Yokoyama, Y; Nagino, M; Ebata, T

    ANNALS OF SURGERY   Vol. 277 ( 3 ) page: E585 - E591   2023.3

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    DOI: 10.1097/SLA.0000000000005248

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  50. Early Prediction of a Serious Postoperative Course in Perihilar Cholangiocarcinoma <i>Trajectory Analysis of the Comprehensive Complication Index</i> Open Access

    Kawakatsu, S; Yamaguchi, J; Mizuno, T; Watanabe, N; Onoe, S; Igami, T; Yokoyama, Y; Uehara, K; Nagino, M; Matsuo, K; Ebata, T

    ANNALS OF SURGERY   Vol. 277 ( 3 ) page: 475 - 483   2023.3

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    DOI: 10.1097/SLA.0000000000005162

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  51. Antitumor Effects of Deep Ultraviolet Irradiation for Pancreatic Cancer Open Access

    Yamazaki, K; Kokuryo, T; Yamaguchi, J; Sunagawa, M; Ogura, A; Watanabe, N; Onoe, S; Miyata, K; Mizuno, T; Uehara, K; Igami, T; Yokoyama, Y; Ebata, T; Nagino, M

    ANTICANCER RESEARCH   Vol. 43 ( 2 ) page: 621 - 630   2023.2

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    DOI: 10.21873/anticanres.16198

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  52. Impact of preoperative muscle mass and quality on surgical outcomes in patients undergoing major hepatectomy for perihilar cholangiocarcinoma Open Access

    Asai, Y; Yamaguchi, J; Mizuno, T; Onoe, S; Watanabe, N; Igami, T; Uehara, K; Yokoyama, Y; Ebata, T

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 30 ( 2 ) page: 202 - 211   2023.2

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    DOI: 10.1002/jhbp.1220

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  53. Structure of MotA, a flagellar stator protein, from hyperthermophile

    Nishikino, T; Takekawa, N; Tran, DP; Kishikawa, J; Hirose, M; Onoe, S; Kojima, S; Homma, M; Kitao, A; Kato, T; Imada, K

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 631   page: 78 - 85   2022.11

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    DOI: 10.1016/j.bbrc.2022.09.072

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  54. Early volume loss of skeletal muscle after esophagectomy: a risk for late-onset postoperative pneumonia Open Access

    Nishimura, K; Miyata, K; Fukaya, M; Yokoyama, Y; Uehara, K; Yamaguchi, J; Mizuno, T; Onoe, S; Ogura, A; Ebata, T

    DISEASES OF THE ESOPHAGUS   Vol. 35 ( 11 )   2022.11

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  55. A proposal of drain removal criteria in hepatobiliary resection

    Watanabe, N; Mizuno, T; Yamaguchi, J; Yokoyama, Y; Igami, T; Onoe, S; Uehara, K; Sunagawa, M; Ebata, T

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 29 ( 9 ) page: 974 - 982   2022.9

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    DOI: 10.1002/jhbp.1194

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  56. Comparison of an Inside Stent and a Fully Covered Self-Expandable Metallic Stent as Preoperative Biliary Drainage for Patients with Resectable Perihilar Cholangiocarcinoma Open Access

    Mori, H; Kawashima, H; Ohno, E; Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Nakamura, M; Ishigami, M; Onoe, S; Mizuno, T; Ebata, T; Fujishiro, M

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 2022   page: 3005210   2022.7

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    DOI: 10.1155/2022/3005210

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  57. Mild Prognostic Impact of Postoperative Complications on Long-term Survival of Perihilar Cholangiocarcinoma

    Kawakatsu, S; Ebata, T; Watanabe, N; Onoe, S; Yamaguchi, J; Mizuno, T; Igami, T; Yokoyama, Y; Matsuo, K; Nagino, M

    ANNALS OF SURGERY   Vol. 276 ( 1 ) page: 146 - 152   2022.7

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    DOI: 10.1097/SLA.0000000000004465

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  58. Superiority of clinical American Joint Committee on Cancer T classification for perihilar cholangiocarcinoma

    Yamada, M; Mizuno, T; Yamaguchi, J; Yokoyama, Y; Igami, T; Onoe, S; Watanabe, N; Uehara, K; Matsuo, K; Ebata, T

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 29 ( 7 ) page: 768 - 777   2022.7

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    DOI: 10.1002/jhbp.1066

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  59. A long-term survivor of advanced retroperitoneal dedifferentiated liposarcoma: a successful multimodal approach with extended resection and chemotherapy Open Access

    Nakahashi, K; Yokoyama, Y; Fukaya, M; Igami, T; Mizuno, T; Yamaguchi, J; Onoe, S; Watanabe, N; Ebata, T

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 1 ) page: 200 - 207   2022.2

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    DOI: 10.18999/nagjms.84.1.200

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  60. Combined Vascular Resection for Locally Advanced Perihilar Cholangiocarcinoma

    Mizuno, T; Ebata, T; Yokoyama, Y; Igami, T; Yamaguchi, J; Onoe, S; Watanabe, N; Kamei, Y; Nagino, M

    ANNALS OF SURGERY   Vol. 275 ( 2 ) page: 382 - 390   2022.2

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    DOI: 10.1097/SLA.0000000000004322

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  61. Fish bone migration after pancreaticoduodenectomy: Incidence and treatment options Open Access

    Takada, Y; Ishikawa, T; Kawashima, H; Mizutani, Y; Ohno, E; Iida, T; Ogawa, H; Hayashi, M; Takami, H; Onoe, S; Ishigami, M

    JOURNAL OF DIGESTIVE DISEASES   Vol. 23 ( 1 ) page: 44 - 49   2022.1

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    DOI: 10.1111/1751-2980.13077

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  62. A clinicopathological reappraisal of intraductal papillary neoplasm of the bile duct (IPNB): a continuous spectrum with papillary cholangiocarcinoma in 181 curatively resected cases Open Access

    Onoe, S; Ebata, T; Yokoyama, Y; Igami, T; Mizuno, T; Yamaguchi, J; Watanabe, N; Otsuka, S; Nakamura, S; Shimoyama, Y; Nagino, M

    HPB   Vol. 23 ( 10 ) page: 1525 - 1532   2021.10

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    DOI: 10.1016/j.hpb.2021.03.004

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  63. [Ⅱ.Treatment for Recurrent Cholangiocarcinoma].

    Watanabe N, Yokoyama Y, Igami T, Uehara K, Mizuno T, Yamaguchi J, Miyata K, Onoe S, Ogura A, Ebata T

    Gan to kagaku ryoho. Cancer & chemotherapy   Vol. 48 ( 10 ) page: 1223 - 1226   2021.10

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  64. Adjuvant S-1 vs gemcitabine for node-positive perihilar cholangiocarcinoma: A propensity score-adjusted analysis

    Takahashi, D; Mizuno, T; Yokoyama, Y; Igami, T; Yamaguchi, J; Onoe, S; Watanabe, N; Maeda, O; Ando, M; Ebata, T

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 28 ( 9 ) page: 716 - 726   2021.9

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    DOI: 10.1002/jhbp.1005

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  65. A presurgical prognostic stratification based on nutritional assessment and carbohydrate antigen 19-9 in pancreatic carcinoma: An approach with nonanatomic biomarkers Open Access

    Onoe, S; Yokoyama, Y; Kokuryo, T; Igami, T; Mizuno, T; Yamaguchi, J; Watanabe, N; Kawakatsu, S; Ebata, T

    SURGERY   Vol. 169 ( 6 ) page: 1463 - 1470   2021.6

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    DOI: 10.1016/j.surg.2020.11.035

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  66. Hepatopancreatoduodenectomy with simultaneous resection of the portal vein and hepatic artery for locally advanced cholangiocarcinoma: Short- and long-term outcomes of superextended surgery

    Nagino, M; Ebata, T; Yokoyama, Y; Igami, T; Mizuno, T; Yamaguchi, J; Onoe, S; Watanabe, N

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 28 ( 4 ) page: 376 - 386   2021.4

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    DOI: 10.1002/jhbp.914

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  67. Application of fluorescent cholangiography during single-incision laparoscopic cholecystectomy in the cystohepatic duct without preoperative diagnosis

    Asai, Y; Igami, T; Ebata, T; Yokoyama, Y; Mizuno, T; Yamaguchi, J; Onoe, S; Watanabe, N; Nagino, M

    ANZ JOURNAL OF SURGERY   Vol. 91 ( 3 ) page: 470 - 472   2021.3

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    DOI: 10.1111/ans.16162

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  68. Impact of the preoperative body composition indexes on intraoperative blood loss in patients undergoing pancreatoduodenectomy

    Ishii, K; Yokoyama, Y; Ebata, T; Igami, T; Mizuno, T; Yamaguchi, J; Onoe, S; Watanabe, N; Nagino, M

    SURGERY TODAY   Vol. 51 ( 1 ) page: 52 - 60   2021.1

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    DOI: 10.1007/s00595-020-02054-y

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  69. Impact of Perioperative Steroid Administration in Patients Undergoing Major Hepatectomy with Extrahepatic Bile Duct Resection: A Randomized Controlled Trial

    Onoe, S; Yokoyama, Y; Ebata, T; Igami, T; Mizuno, T; Yamaguchi, J; Watanabe, N; Suzuki, S; Nishiwaki, K; Ando, M; Nagino, M

    ANNALS OF SURGICAL ONCOLOGY   Vol. 28 ( 1 ) page: 121 - 130   2021.1

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    DOI: 10.1245/s10434-020-08745-7

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  70. Study of the Portal Branches Arising from the Cranial Part of the Umbilical Portion of the Left Portal Vein: Implications for Anatomic Right Hepatic Trisectionectomy

    Minami, T; Ebata, T; Yokoyama, Y; Igami, T; Mizuno, T; Yamaguchi, J; Onoe, S; Watanabe, N; Nagino, M

    WORLD JOURNAL OF SURGERY   Vol. 44 ( 12 ) page: 4231 - 4235   2020.12

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    DOI: 10.1007/s00268-020-05753-2

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  71. ASO Author Reflections: Is Perioperative Steroids Administration Beneficial for Patients Undergoing Major Hepatectomy with Extrahepatic Bile Duct Resection?

    Onoe, S; Yokoyama, Y; Ebata, T; Nagino, M

    ANNALS OF SURGICAL ONCOLOGY   Vol. 27 ( Suppl 3 ) page: 808 - 809   2020.12

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    DOI: 10.1245/s10434-020-08804-z

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  72. How long should follow-up be continued after R0 resection of perihilar cholangiocarcinoma? Open Access

    Nakahashi, K; Ebata, T; Yokoyama, Y; Igami, T; Mizuno, T; Yamaguchi, J; Onoe, S; Watanabe, N; Nagino, M

    SURGERY   Vol. 168 ( 4 ) page: 617 - 624   2020.10

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    DOI: 10.1016/j.surg.2020.04.068

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  73. Tumor marker recovery rather than major pathological response is a preferable prognostic factor in patients with pancreatic ductal adenocarcinoma with preoperative therapy

    Yamada Suguru, Yokoyama Yukihiro, Sonohara Fuminori, Yamaguchi Junpei, Takami Hideki, Hayashi Masamichi, Onoe Shunsuke, Fujii Tsutomu, Nagino Masato, Kodera Yasuhiro

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES     2020.5

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    DOI: 10.1002/jhbp.748

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  74. Postoperative infectious complications caused by multidrug-resistant pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection.

    Sugawara G, Yokoyama Y, Ebata T, Igami T, Yamaguchi J, Mizuno T, Onoe S, Watanabe N, Nagino M

    Surgery     2020.4

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    DOI: 10.1016/j.surg.2020.02.015

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  75. The influence of the preoperative thickness of the abdominal cavity on the gastrojejunal anatomic position and delayed gastric emptying after pancreatoduodenectomy. Open Access

    Watanabe N, Yokoyama Y, Ebata T, Igami T, Mizuno T, Yamaguchi J, Onoe S, Nagino M

    HPB : the official journal of the International Hepato Pancreato Biliary Association     2020.4

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    DOI: 10.1016/j.hpb.2020.03.016

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  76. Study on the Segmentation of the Right Posterior Sector of the Liver

    Minami Takayuki, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    WORLD JOURNAL OF SURGERY   Vol. 44 ( 3 ) page: 896-901   2020.3

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    DOI: 10.1007/s00268-019-05238-x

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  77. Predictive performance of Blumgart T staging for perihilar cholangiocarcinoma in a Japanese center

    Ebata Tomoki, Mizuno Takashi, Yokoyama Yukihiro, Igami Tsuyoshi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 27 ( 3 ) page: 132-140   2020.3

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    DOI: 10.1002/jhbp.694

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  78. A case of small in situ perihilar cholangiocarcinoma incidentally accompanied by benign bile duct stricture after open cholecystectomy Open Access

    Maeda Takashi, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    SURGICAL CASE REPORTS   Vol. 5 ( 1 ) page: 177   2019.12

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    DOI: 10.1186/s40792-019-0745-z

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  79. Postoperative Pancreatic Fistula in Surgery for Perihilar Cholangiocarcinoma

    Watanabe Nobuyuki, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Nagino Masato

    WORLD JOURNAL OF SURGERY   Vol. 43 ( 12 ) page: 3094-3100   2019.12

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    DOI: 10.1007/s00268-019-05127-3

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  80. Benign hilar bile duct strictures resected as perihilar cholangiocarcinoma

    Otsuka S., Ebata T., Yokoyama Y., Igami T., Mizuno T., Yamaguchi J., Onoe S., Watanabe N., Shimoyama Y., Nagino M.

    BRITISH JOURNAL OF SURGERY   Vol. 106 ( 11 ) page: 1504-1510   2019.10

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    DOI: 10.1002/bjs.11257

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  81. Discrepancy between volume and functional recovery in early phase liver regeneration following extended hepatectomy with extrahepatic bile duct resection

    Maeda Takashi, Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Ando Masahiko, Nagino Masato

    HEPATOLOGY RESEARCH   Vol. 49 ( 10 ) page: 1227-1235   2019.10

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    DOI: 10.1111/hepr.13378

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  82. Cholangiographic Tumor Classification for Simple Patient Selection Prior to Hepatopancreatoduodenectomy for Cholangiocarcinoma

    Toyoda Yoshitaka, Ebata Tomoki, Mizuno Takashi, Yokoyama Yukihiro, Igami Tsuyoshi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    ANNALS OF SURGICAL ONCOLOGY   Vol. 26 ( 9 ) page: 2971-2979   2019.9

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    DOI: 10.1245/s10434-019-07457-x

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  83. Occult synchronous liver metastasis from perihilar cholangiocarcinoma Open Access

    Ohiwa Takashi, Ebata Tomoki, Mizuno Takashi, Yokoyama Yukihiro, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    SURGERY   Vol. 166 ( 3 ) page: 290-296   2019.9

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    DOI: 10.1016/j.surg.2019.04.029

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  84. Preoperative course of patients undergoing endoscopic nasobiliary drainage during the management of resectable perihilar cholangiocarcinoma Open Access

    Maeda Takashi, Ebata Tomoki, Yokoyama Yukihiro, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Kawashima Hiroki, Nagino Masato

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 26 ( 8 ) page: 341-347   2019.8

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    DOI: 10.1002/jhbp.640

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  85. Left trisectionectomy combined with resection of the right hepatic vein and inferior vena cava after right hepatic vein embolization for advanced intrahepatic cholangiocarcinoma Open Access

    Suzuki Toshihiro, Ebata Tomoki, Yokoyama Yukihiro, Mizuno Takashi, Igami Tsuyoshi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    SURGICAL CASE REPORTS   Vol. 5 ( 1 ) page: 98   2019.6

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    DOI: 10.1186/s40792-019-0655-0

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  86. Pleural dissemination of cholangiocarcinoma caused by percutaneous transhepatic biliary drainage during the management of resectable cholangiocarcinoma

    Yamashita Hiromasa, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Ando Masahiko, Nagino Masato

    SURGERY   Vol. 165 ( 5 ) page: 912-917   2019.5

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    DOI: 10.1016/j.surg.2018.10.015

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  87. A Study on Radial Margin Status in Resected Perihilar Cholangiocarcinoma.

    Shinohara K, Ebata T, Shimoyama Y, Mizuno T, Yokoyama Y, Yamaguchi J, Onoe S, Watanabe N, Nagino M

    Annals of surgery     2019.4

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    DOI: 10.1097/SLA.0000000000003305

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  88. Major hepatectomy with or without pancreatoduodenectomy for advanced gallbladder cancer Open Access

    Mizuno T., Ebata T., Yokoyama Y., Igami T., Yamaguchi J., Onoe S., Watanabe N., Ando M., Nagino M.

    BRITISH JOURNAL OF SURGERY   Vol. 106 ( 5 ) page: 626-635   2019.4

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    DOI: 10.1002/bjs.11088

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  89. The Prognostic Impact of the Lymphocyte-to-Monocyte Ratio in Resected Pancreatic Head Adenocarcinoma. Open Access

    Onoe S, Maeda A, Takayama Y, Fukami Y, Takahashi T, Uji M, Kaneoka Y

    Medical principles and practice : international journal of the Kuwait University, Health Science Centre   Vol. 28 ( 6 ) page: 517-525   2019

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    DOI: 10.1159/000501017

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  90. Comparison between autologous and homologous blood transfusions in liver resection for biliary tract cancer: a propensity score matching analysis

    Onoe Shunsuke, Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Watanabe Nobuyuki, Nagino Masato

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 25 ( 12 ) page: 550-559   2018.12

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    DOI: 10.1002/jhbp.592

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  91. Surgery for perihilar cholangiocarcinoma from a viewpoint of age: Is it beneficial to octogenarians in an aging society?

    Akashi Kumiko, Ebata Tomoki, Mizuno Takashi, Yokoyama Yukihiro, Igami Tsuyoshi, Yamaguchi Junpei, Onoe Shunsuke, Nagino Masato

    SURGERY   Vol. 164 ( 5 ) page: 1023-1029   2018.11

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    DOI: 10.1016/j.surg.2018.05.051

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  92. Comparison of outcomes of laparoscopy-assisted and open proximal gastrectomy with jejunal interposition for early gastric cancer in the upper third of the stomach: A retrospective observational study.

    Takayama Y, Kaneoka Y, Maeda A, Fukami Y, Onoe S

    Asian journal of endoscopic surgery   Vol. 11 ( 4 ) page: 329-336   2018.11

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    DOI: 10.1111/ases.12469

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  93. Ethanol ablation for refractory bile leakage after complex hepatectomy Open Access

    Ito A., Ebata T., Yokoyama Y., Igami T., Mizuno T., Yamaguchi J., Onoe S., Nagino M.

    BRITISH JOURNAL OF SURGERY   Vol. 105 ( 8 ) page: 1036 - 1043   2018.7

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    DOI: 10.1002/bjs.10801

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  94. Internal hernia after proximal gastrectomy with jejunal interposition.

    Takayama Y, Kaneoka Y, Maeda A, Fukami Y, Takahashi T, Onoe S, Uji M

    Updates in surgery   Vol. 70 ( 1 ) page: 85-90   2018.3

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    DOI: 10.1007/s13304-017-0497-x

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  95. Determination of therapeutic strategy for adhesive small bowel obstruction using water-soluble contrast agents: An audit of 776 cases in a single center.

    Mori H, Kaneoka Y, Maeda A, Takayama Y, Takahashi T, Onoe S, Fukami Y

    Surgery   Vol. 162 ( 1 ) page: 139-146   2017.7

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    DOI: 10.1016/j.surg.2017.01.023

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  96. Extracorporeal Hand-Sewn Anastomosis Through a Minilaparotomy in Laparoscopic Distal Gastrectomy.

    Takayama Y, Kaneoka Y, Maeda A, Fukami Y, Onoe S

    Journal of laparoendoscopic & advanced surgical techniques. Part A   Vol. 27 ( 7 ) page: 726-732   2017.7

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    DOI: 10.1089/lap.2016.0133

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  97. Preoperative radiographic vascular involvement score predicts the prognosis of resected pancreatic head adenocarcinoma.

    Onoe S, Kaneoka Y, Maeda A, Takayama Y, Fukami Y

    Langenbeck's archives of surgery   Vol. 402 ( 3 ) page: 439-446   2017.5

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    DOI: 10.1007/s00423-017-1562-0

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  98. A preoperative predictive scoring system to predict the ability to achieve the critical view of safety during laparoscopic cholecystectomy for acute cholecystitis. Open Access

    Onoe S, Maeda A, Takayama Y, Fukami Y, Kaneoka Y

    HPB : the official journal of the International Hepato Pancreato Biliary Association   Vol. 19 ( 5 ) page: 406-410   2017.5

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    DOI: 10.1016/j.hpb.2016.12.013

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  99. Ultrasonic energy device versus monopolar energy device in laparoscopic transabdominal preperitoneal (TAPP) inguinal hernia repair.

    Otsuka S, Kaneoka Y, Maeda A, Takayama Y, Fukami Y, Onoe S

    Updates in surgery   Vol. 69 ( 1 ) page: 55-60   2017.3

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    DOI: 10.1007/s13304-016-0412-x

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  100. Bilobar versus unilobar multiple colorectal liver metastases: a propensity score analysis of surgical outcomes and recurrence patterns

    Fukami Yasuyuki, Kaneoka Yuji, Maeda Atsuyuki, Takayama Yuichi, Takahashi Takamasa, Onoe Shunsuke, Uji Masahito, Wakai Kenji

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 24 ( 3 ) page: 153-160   2017.3

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    DOI: 10.1002/jhbp.427

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  101. Postoperative complications following aggressive repeat hepatectomy for colorectal liver metastasis have adverse oncological outcomes.

    Fukami Y, Kaneoka Y, Maeda A, Takayama Y, Onoe S

    Surgery today   Vol. 47 ( 1 ) page: 99-107   2017.1

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    DOI: 10.1007/s00595-016-1340-6

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  102. Feasibility of laparoscopic cholecystectomy for acute cholecystitis beyond 72 h of symptom onset.

      Vol. 68 ( 4 ) page: 377-383   2016.12

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    DOI: 10.1007/s13304-016-0409-5

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  103. Prognostic impact of splenic artery invasion for pancreatic cancer of the body and tail.

    Fukami Y, Kaneoka Y, Maeda A, Takayama Y, Onoe S

    International journal of surgery (London, England)   Vol. 35   page: 64-68   2016.11

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    DOI: 10.1016/j.ijsu.2016.09.076

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  104. Major hepatopancreatoduodenectomy with simultaneous resection of the hepatic artery for advanced biliary cancer.

    Fukami Y, Kaneoka Y, Maeda A, Takayama Y, Onoe S

    Langenbeck's archives of surgery   Vol. 401 ( 4 ) page: 471-8   2016.6

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    DOI: 10.1007/s00423-016-1413-4

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  105. Benefit of extended radical surgery for incidental gallbladder carcinoma Open Access

    Yamaguchi Junpei, Kaneoka Yuji, Maeda Atsuyuki, Takayama Yuichi, Onoe Shunsuke, Isogai Masatoshi

    SURGERY TODAY   Vol. 46 ( 4 ) page: 453-459   2016.4

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    DOI: 10.1007/s00595-015-1198-z

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  106. Hepatic Artery Reconstruction with a Continuous Suture Method for Hepato-Biliary-Pancreatic Surgery.

    Otsuka S, Kaneoka Y, Maeda A, Takayama Y, Fukami Y, Onoe S

    World journal of surgery   Vol. 40 ( 4 ) page: 951-7   2016.4

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    DOI: 10.1007/s00268-015-3310-3

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  107. Positive surgical margins in surgically treated unifocal and multifocal IPMN.

    Yamaguchi J, Kaneoka Y, Maeda A, Takayama Y, Onoe S, Isogai M

    International journal of surgery (London, England)   Vol. 28   page: 51-5   2016.4

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    DOI: 10.1016/j.ijsu.2016.02.065

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  108. Simultaneous resection for colorectal cancer and synchronous liver metastases.

    Fukami Y, Kaneoka Y, Maeda A, Takayama Y, Onoe S, Isogai M

    Surgery today   Vol. 46 ( 2 ) page: 176-82   2016.2

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    DOI: 10.1007/s00595-015-1188-1

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  109. Hepatectomy of segment 4b and 5 with extrahepatic bile duct resection for pT2 gallbladder carcinoma is valid: a single-institution result.

    Onoe S, Kaneoka Y, Maeda A, Takayama Y, Fukami Y, Isogai M

    Updates in surgery   Vol. 67 ( 3 ) page: 265-71   2015.9

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    DOI: 10.1007/s13304-015-0319-y

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  110. Intrapancreatic bile duct metastasis from colon cancer after resection of liver metastasis with intrabiliary growth: a case report. Open Access

    Kawakatsu S, Kaneoka Y, Maeda A, Takayama Y, Fukami Y, Onoe S

    World journal of surgical oncology   Vol. 13   page: 254   2015.8

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    DOI: 10.1186/s12957-015-0676-5

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  111. Clinicopathological Significance of Mucin Production in Patients with Papillary Cholangiocarcinoma

    Onoe Shunsuke, Shimoyama Yoshie, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Nakamura Shigeo, Nagino Masato

    WORLD JOURNAL OF SURGERY   Vol. 39 ( 5 ) page: 1177-1184   2015.5

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    DOI: 10.1007/s00268-014-2923-2

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  112. Does Gadoxetic acid-enhanced 3.0T MRI in addition to 64-detector-row contrast-enhanced CT provide better diagnostic performance and change the therapeutic strategy for the preoperative evaluation of colorectal liver metastases?

    Sofue K, Tsurusaki M, Murakami T, Onoe S, Tokue H, Shibamoto K, Arai Y, Sugimura K

    European radiology   Vol. 24 ( 10 ) page: 2532-9   2014.10

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    DOI: 10.1007/s00330-014-3233-7

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  113. Synchronous unilateral triple breast cancers composed of invasive ductal carcinoma, invasive lobular carcinoma, and Paget's disease.

    Onoe S, Tsuda H, Akashi-Tanaka S, Hasebe T, Iwamoto E, Hojo T, Kinoshita T

    Breast cancer (Tokyo, Japan)   Vol. 21 ( 2 ) page: 241-5   2014.3

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    DOI: 10.1007/s12282-010-0245-2

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  114. Prognostic delineation of papillary cholangiocarcinoma based on the invasive proportion: A single-institution study with 184 patients Open Access

    Onoe Shunsuke, Shimoyama Yoshie, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Get, Nakamura Shigeo, Nagino Masato

    SURGERY   Vol. 155 ( 2 ) page: 280-291   2014.2

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    DOI: 10.1016/j.surg.2013.08.011

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  115. Prognostic delineation of papillary cholangiocarcinoma based on the invasive proportion

    Onoe, S; Shimoyama, Y; Ebata, T; Yokoyama, Y; Igami, T; Sugawara, G; Nakamura, S; Nagino, M

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 31 ( 15 )   2013.5

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  116. Feasibility of breast conserving surgery for Paget's disease. Open Access

    Onoe S, Kinoshita T, Tamura N, Nagao T, Kuno H, Hojo T, Akashi-Tanaka S, Tsuda H

    Breast (Edinburgh, Scotland)   Vol. 20 ( 6 ) page: 515-8   2011.12

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    DOI: 10.1016/j.breast.2011.05.010

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  117. A case of hepatic metastasis from gastric GIST successfully resected following neoadjuvant targeted therapy.

    Onoe S, Sakamoto Y

    Japanese journal of clinical oncology   Vol. 41 ( 4 ) page: 590   2011.4

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    DOI: 10.1093/jjco/hyr040

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KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. In vivo 門脈血流イメージングを指標にする胆道癌肝切除の新規外科治療戦略

    Grant number:26K11639  2026.4 - 2029.3

    科学研究費助成事業  基盤研究(C)

    江畑 智希, 渡辺 伸元, 尾上 俊介, 川勝 章司, 馬場 泰輔, 山田 美保子, 砂川 真輝, 國料 俊男, 水野 隆史

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    Authorship:Coinvestigator(s) 

    胆道癌肝切除における術後死亡率は今でも高く世界的な問題である。今回、手術に伴う門脈形態の経時的変化が門脈血流不全を介して肝不全の原因になるという仮説を立て、門脈形態と門脈血行動態から新規外科治療戦略を構築することを計画した。本研究で用いる3次元シネ位相コントラストMRIにより門脈血栓症のリスク同定、術前・術後にかけての門脈解剖の経時的変化、術後門脈血行動態の解析、門脈切除再建法と門脈血行動態との関係を検討し、切除後の多彩な門脈形態の中に潜む“高リスク形態”を同定し、外科介入が必要な形として新たな診療指針を提出したい。また、同時に“理想的な形態”も追求し、現行の門脈切除再建手技を再構築する。

  2. Study on the molecular subtypes of bile duct cancer based on RNA-seq analysis.

    Grant number:24K11928  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

  3. 胆道癌肝切除における術後経過の視覚的解析手法と経過不良群予測システムの開発

    Grant number:23K08127  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    江畑 智希, 川勝 章司, 渡辺 伸元, 尾上 俊介, 水野 隆史, 山口 淳平, 國料 俊男

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    胆管切除を伴う肝切除は現在でも手術後死亡率が5-10%である。今まで、特定の術後合併症に注目し改善策が提案されてきたが、死亡率低下にはつながっていない。近年、合併症の総量を算出する方法が報告されたが、われわれはその総量が経時的蓄積量として視覚的に表現できることを発見した。
    本研究では、従来曖昧に扱われてきた術後経過を包括化・可視化・類型化し、予後不良群の特定、その特徴や予測因子を調査する。本研究の目標は経過不良群の早期予測システムの開発であり、今までなしえなかった術後死亡率の低下に貢献することである。
    胆道癌に対する治療の第一選択は外科切除であり、胆管切除を伴う肝切除は標準手術の一つである。本術式が提唱されすでに30年ほど経過しているが、現在でも手術後死亡率が5-10%と報告され、消化器外科手術の中で際立って高い。今まで、特定の術後合併症に注目した検討により個々の危険因子や改善策が提案され、周術期管理プログラムの中に組み込まれてきた。本アプローチは個別の合併症の軽減には有用であったが、死亡率の低下に大きく貢献することはなかった。この理由として、複合的・遂次的に発生する雑多な有害事象が、相互に影響していることがあげられる。近年、合併症の数と程度を考慮し、その総量を算出する
    方法が報告された。われわれは本評価法に新たに時間要素を加味し、術後合併症の経時的蓄積量として視覚的に表現できることを発見した。
    本研究では、従来曖昧に扱われてきた術後経過を包括化・可視化・類型化し、予後不良(術後死亡)群の特定、その特徴や予測・寄与因子を同定する。その目標は経過不良群の早期予測システムの開発であり、今までなしえなかった術後死亡率の低下に貢献することである。行き詰った合併症研究に対し、高死亡率の機序を新たな方法論で解明する本プロジェクトは、本邦のみならず世界の外科臨床に与える影響が大きいと考えられる。
    <BR>
    現在大きい課題として進捗しているのは、以下の3つである。1)肝切除の新規術式(拡大左葉切除)の術後経過における肝機能推移を解析し、問題のないことを検証した。現在論文投稿中である。2)合併総量の評価は2週間でほぼプラトーに達することを発見し、至適時期として提唱可能であることを発見した。解析終了した。3)同じ肝切除量である肝右葉切除において、負荷術式が術後経過に与える影響を検証した。ここでは新たにリアルタイムにCCIを追跡する手法を開発した。
    現在3年目を迎え、2年目に達成した事項を下記に示す。1)データ集積は終了した。2)肝切除の新規術式(拡大左葉切除)の術後経過における肝機能推移を解析し、問題のないことを検証した。現在論文投稿中である。3)合併総量の評価は2週間でほぼプラトーに達することを発見し、至適時期として提唱可能であることを発見した。解析終了した。4)同じ肝切除量である肝右葉切除において、負荷術式が術後経過に与える影響を検証した。ここでは新たにリアルタイムにCCIを追跡する手法を開発した。5)術中・後の門脈血栓発生機序についても研究を開始した。
    これらの解析、論文化がおおむね順調に進行しており、3年目に促進する予定である。
    ここまでの研究により、CCIを用いてその実測値を利用した解析のみならず、新規の術後経過の視覚化手法として、連続的累積変化をTrajectory解析する方法とリアルタイムに評価する方法を開発した。
    <BR>
    胆道癌肝切除という切除術式の特殊性が明らかになり、術後経過は年齢、出血量、残肝サイズの連続変数により大きく規定されることが発見された。この3因子の中では出血量だけが調整可能な因子である。今後は年齢別や残肝サイズ別に安全な術後経過を目標にした出血量が設定できる可能性がある。今まで不明瞭であった術後経過不良のプロセスが明らかになりつつある。

  4. Novel treatment using adipose stem cell for postoperative liver damage

    Grant number:19K09118  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    ONOE Shunsuke

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    Adipose stem cell sheets have no side effect, such as ascites retention or infection in the mouse model of 30% hepatectomy and partial hepatectomy. Angiogenesis was increased in the sheet in time dependent manner. A fluorescent-labeled human adipose stem cells were identified on the liver side of the mouse. Interestingly, a large number of mouse cells were observed in the human adipose stem cell sheet. These results suggest that bidirectional migration between human adipose stem cells and mouse cells is involved in liver regeneration using a human adipose stem cell sheet.

  5. The comprehensive sequence analysis of genes concerning malignant alteration in the bile duct cancer

    Grant number:17H06750  2017.8 - 2019.3

    ONOE SYUNSUKE

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    Authorship:Principal investigator 

    Grant amount:\2730000 ( Direct Cost: \2100000 、 Indirect Cost:\630000 )

    Gene sequences were analyzed in heterochronic cholangiocarcinomas by next-generation sequencing.In case 1, several gene mutations were identified in APC, CDKN2A, CDKN2B, CDKN1B, MDM2, CD274 and STK11 in the primary lesion and in APC, CDKN2A, CDKN2B, CDKN1B, MDM2, CD274, STK11, PTPRD, SMAD4, KEAP1, ARID1A, FBXW7 and PIK3R1 in the secondary lesion. In case 2, several variations were found in APC, TP53, JAK1, RB1, SMAD4 and AMER1 in the primary lesion and in APC, TP53, JAK1, RB1, SMAD4, AMER1, KRAS, CDKN2A and CDKN2B in the secondary lesion. The common mutations were those in APC, CDKN2A, CDKN2B and SMAD4 in both cases. New variations in the secondary lesion were detected, compared with those in the primary lesion, in heterochronic cholangiocarcinoma.
    Further investigations will be required to clarify the malignant alterations. Our results are thought to be a clue for the development of novel methods for the diagnosis and therapy of cancer.