研究者詳細 - 田中　哲人

論文 - 田中　哲人

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Coronary air embolism following transbronchial lung biopsy 査読有り

Sumi Takuya, Tanaka Akihito, Ishii Hideki, Suzuki Susumu, Kada Kenji, Murohara Toyoaki

CARDIOVASCULAR INTERVENTION AND THERAPEUTICS 34 巻 ( 1 ) 頁： 64 - 66 2019年1月

Impact of Nutritional and Inflammation Status on Long-Term Bleeding in Patients Undergoing Percutaneous Coronary Intervention with an Oral Anticoagulant 査読有り

Yoshida Ruka, Ishii Hideki, Morishima Itsuro, Tanaka Akihito, Morita Yasuhiro, Takagi Kensuke, Yoshioka Naoki, Hirayama Kenshi, Iwakawa Naoki, Tashiro Hiroshi, Kojima Hiroki, Mitsuda Takayuki, Hitora Yusuke, Furusawa Kenji, Tsuboi Hideyuki, Murohara Toyoaki

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 26 巻 ( 8 ) 頁： 728 - 737 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本動脈硬化学会

Aim: Patients undergoing percutaneous coronary intervention (PCI) who require both oral anticoagulant (OAC) and antiplatelet therapy (APT) are exposed to a serious risk of bleeding. The aim of this study was to clarify the relationship among nutritional and inflammation status and long-term bleeding in patients requiring both OACs and APT after PCI. Methods: We performed PCI in 3,718 consecutive patients between April 2011 and March 2017, 302 of whom were treated with both OACs and APT. Patients were followed for up to 3 years for bleeding events, defined as the Bleeding Academic Research Consortium (BARC) class ≥ 3 bleeding. We retrospectively evaluated the ability of the Geriatric Nutritional Risk Index (GNRI) and high-sensitivity C-reactive protein (hs-CRP) to detect bleeding events. Results: During a median follow-up of 1,080 days, bleeding events were observed in 53 (17.5%) patients. Bleeding events were associated with a low GNRI (≤ 98) (hazard ratio [HR], 3.16; 95% confidence interval [CI], 1.84 – 5.45; p＜0.0001) and hs-CRP level ≥ 2.5 mg/L (HR, 2.75; 95% CI, 1.61 – 4.78; p=0.0003). A low GNRI＋ high hs-CRP showed a 5.12-fold increase in the incidence of BARC class ≥ 3 bleeding (95% CI, 2.68 – 9.91; p＜ 0.0001) compared with a normal GNRI＋low hs-CRP. The addition of the GNRI and hs-CRP to the PRECISE-DAPT score improved C-statistics from 0.67 to 0.71 and enhanced the net reclassification improvement (NRI) and integrated discrimination improvement (IDI) (NRI, 0.36, p＜0.0001; IDI, 0.066, p＜0.0001). Conclusions: The GNRI and hs-CRP were novel predictors of the long-term bleeding risk in patients requiring both OACs and APT after PCI.

DOI： 10.5551/jat.47654

Early versus delayed invasive strategy in patients with non-ST-elevation acute coronary syndrome and concomitant congestive heart failure 査読有り

JOURNAL OF CARDIOLOGY 74 巻 ( 3-4 ) 頁： 320 - 327 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Cardiology

Background: Although there are guidelines that recommend an early invasive strategy in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) and concomitant congestive heart failure (CHF), optimal timing of the invasive strategy remains controversial. Methods: Among 2045 patients who were admitted owing to NSTE-ACS or CHF, 300 presented with NSTE-ACS and concomitant CHF. Of the 300 patients, we enrolled 160 patients for whom coronary angiography (CAG) during their hospital stay was planned at the time of admission; 64 of these patients were classified into the early invasive group (<24 h) and 96 were classified to the delayed invasive group (≥24 h). We evaluated the primary outcome which was defined as a composite of cardiac mortality, life-threatening arrhythmia, and non-fatal myocardial infarction (MI). Results: The median time between presentation and CAG was 2 h in the early invasive group and 240 h in the delayed group. During follow-up, the primary outcome was significantly lower in the early invasive group [hazard ratio (HR), 0.52; 95% confidence interval (CI), 0.30–0.87; p = 0.01]. After the adjustment of confounding factors, the primary outcome was significantly less frequent (HR, 0.44; 95% CI, 0.23–0.78; p = 0.004) in the early invasive group compared to the delayed invasive group. Conclusions: The early invasive strategy was associated with a lower risk of the composite primary outcome in the long-term follow-up of patients with NSTE-ACS and concomitant CHF.

DOI： 10.1016/j.jjcc.2019.03.006

JCS GUIDELINES : JCS 2018 Guideline on Diagnosis and Treatment of Acute Coronary Syndrome

Kimura Kazuo, Kimura Takeshi, Ishihara Masaharu, Nakagawa Yoshihisa, Nakao Koichi, Miyauchi Katsumi, Sakamoto Tomohiro, Tsujita Kenichi, Hagiwara Nobuhisa, Miyazaki Shunichi, Ako Junya, Arai Hirokuni, Ishii Hideki, Origuchi Hideki, Shimizu Wataru, Takemura Hirofumi, Tahara Yoshio, Morino Yoshihiro, Iino Kenji, Itoh Tomonori, Iwanaga Yoshitaka, Uchida Keiji, Endo Hirohisa, Kongoji Ken, Sakamoto Kenji, Shiomi Hiroki, Shimohama Takao, Suzuki Atsushi, Takahashi Jun, Takeuchi Ichiro, Tanaka Akihito, Tamura Toshihiro, Nakashima Takahiro, Noguchi Teruo, Fukamachi Daisuke, Mizuno Tomohiro, Yamaguchi Junichi, Yodogawa Kenji, Kosuge Masami, Kohsaka Shun, Yoshino Hideaki, Yasuda Satoshi, Shimokawa Hiroaki, Hirayama Atsushi, Akasaka Takashi, Haze Kazuo, Ogawa Hisao, Tsutsui Hiroyuki, Yamazaki Tsutomu

日本循環器學誌 83 巻 ( 5 ) 頁： 1085 - 1196 2019年

Myocardial salvage after ST-segment-elevation myocardial infarction: comparison between prasugrel and clopidogrel in the presence or absence of high-residual platelet reactivity 査読有り

Yoshida Ruka, Takagi Kensuke, Ishii Hideki, Morishima Itsuro, Tanaka Akihito, Morita Yasuhiro, Kanzaki Yasunori, Nagai Hiroaki, Watanabe Naoki, Furui Koichi, Shibata Naoki, Yoshioka Naoki, Yamauchi Ryota, Komeyama Shotaro, Sugiyama Hiroki, Tsuboi Hideyuki, Murohara Toyoaki

JOURNAL OF NUCLEAR CARDIOLOGY 28 巻 ( 4 ) 頁： 1422 - 1434 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Nuclear Cardiology

Background: The effect of prasugrel over clopidogrel on myocardial salvage in ST-segment-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (p-PCI) is not fully elucidated. Methods: Among 854 consecutive STEMI patients who underwent p-PCI, 446 patients were evaluated by two-phase (7 days and 3 months) single-photo emission computed tomography (SPECT). Patients were divided into two groups based on the loading P2Y12 inhibitor. The clopidogrel group was further divided based on the result of platelet function testing. Thus, the prasugrel group included 227 patients; the clopidogrel without high-residual platelet reactivity (HRPR) group, 109 patients; and the clopidogrel with HRPR group, 107 patients. The primary endpoint was the Myocardial Salvage Index (MSI), determined by SPECT. Results: The incidence of final TIMI 0/1 and TIMI myocardial perfusion grade 0/1 was higher in the clopidogrel with HRPR group (0.9%, 1.8%, and 7.5%, P = .002; 19.8%, 29.4%, and 41.1%, P = .0002, in the prasugrel, clopidogrel without HRPR, and clopidogrel with HRPR groups, respectively). The MSI was significantly lower in the clopidogrel with HRPR group (48% [27-66], 44% [30-72], and 36% [15-55], P = .006, respectively). Conclusions: Prasugrel in STEMI patients was associated with an increased MSI compared with clopidogrel in the presence of HRPR.

DOI： 10.1007/s12350-019-01852-3

Incidence, Technical Safety, and Feasibility of Coronary Angiography and Intervention Following Self-expanding Transcatheter Aortic Valve Replacement. 査読有り

Tanaka A, Jabbour RJ, Testa L, Agnifili M, Ettori F, Fiorina C, Adamo M, Bruschi G, Giannini C, Petronio AS, Barbanti M, Tamburino C, De Felice F, Reimers B, Poli A, Colombo A, Latib A

Cardiovascular revascularization medicine : including molecular interventions 20 巻 ( 5 ) 頁： 371 - 375 2019年

A survival case of a young adult patient with ST-elevated myocardial infarction with high levels of lipoprotein(a)

Hiraiwa H., Morimoto R., Okumura T., Arao Y., Oishi H., Kato H., Yamaguchi S., Kuwayama T., Haga T., Yokoi T., Kondo T., Watanabe N., Mitsuda T., Fukaya K., Sawamura A., Tanaka A., Ishii H., Morishima I., Tsuboi H., Murohara T.

Journal of Cardiology Cases 19 巻 ( 6 ) 頁： 207 - 210 2019年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Cardiology Cases

A 23-year-old Japanese man presented to a nearby hospital with a complaint of chest pain. In terms of the risk factors for cardiovascular events, there were no abnormal findings in past medical examinations and no smoking history. The 12-lead electrocardiogram revealed ST-elevation in V1-V6, I, and aVL, and he was diagnosed with acute myocardial infarction. Emergency coronary angiography findings revealed total occlusion of the left main trunk and collateral vessels from the right coronary artery to the left anterior descending artery. He underwent emergency percutaneous coronary intervention and placement of drug-eluting stent under the support of venoarterial-extracorporeal membrane oxygenator (VA-ECMO). On day 8 after the onset, transthoracic echocardiography revealed that cardiac function improved with left ventricular ejection fraction from 10% to 20% and VA-ECMO was successfully removed. Alternatively, laboratory findings revealed abnormally high levels of serum lipoprotein(a) [Lp(a), 74 mg/dL] despite the normal levels of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride. In addition, computed tomography angiography revealed atherosclerosis and stenosis of internal and external carotid arteries, subclavian artery, and renal artery. The abnormally high levels of serum Lp(a) could influence systemic atherosclerosis as well as the onset of myocardial infarction in our young adult patient. <Learning objective: This was a rare survival case of a young adult patient with acute extensive myocardial infarction owing to plaque rupture of the left main trunk. Additionally, he had atherosclerosis of the whole body, including the carotid artery, subclavian artery, and renal artery. Blood test results revealed abnormally high levels of serum lipoprotein(a) [Lp(a)] despite the normal levels of low-density lipoprotein cholesterol. Lp(a) could strongly influence coronary atherosclerosis and myocardial infarction.>

DOI： 10.1016/j.jccase.2019.02.004

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New-generation drug-eluting stents for left main coronary artery disease according to the EXCEL trial enrollment criteria: Insights from the all-comers, international, multicenter DELTA-2 registry. 査読有り国際共著

Tanaka A, Giustino G, Briede I, Sawaya FJ, Daemen J, Kawamoto H, Meliga E, D'Ascenzo F, Cerrato E, Stefanini GG, Capodanno D, Mangiameli A, Templin C, Erglis A, Morice MC, Mehran R, Van Mieghem NM, Nakamura S, De Benedictis M, Pavani M, Varbella F, Pisaniello M, Sharma SK, Tamburino C, Tchetche D, Colombo A, Chieffo A, DELTA 2 Investigators.

International journal of cardiology 280 巻頁： 30 - 37 2018年12月

New-Generation Drug-Eluting Stents for Left Main In-Stent Restenosis: The DELTA-2 Registry. 査読有り国際共著

Giustino G, Tanaka A, Erglis A, Morice MC, Van Mieghem NM, Meliga E, D'Ascenzo F, Stefanini GG, Capodanno D, Chieffo A, DELTA-2 Investigators.

JACC. Cardiovascular interventions 11 巻 ( 23 ) 頁： 2438-2440 - 2440 2018年12月

Long-term follow-up of BVS from a prospective multicenter registry: Impact of a dedicated implantation technique on clinical outcomes. 査読有り

Regazzoli D, Latib A, Ezhumalai B, Tanaka A, Leone PP, Khan S, Kumar V, Rastogi V, Ancona MB, Mangieri A, Giannini F, Mitomo S, Seth A, Colombo A

International journal of cardiology 270 巻頁： 113-117 - 117 2018年11月

Vasospastic angina in a 16-year-old female 査読有り

Sumi Takuya, Tanaka Akihito, Ishii Hideki, Suzuki Susumu, Oguri Mitsutoshi, Murohara Toyoaki

CARDIOVASCULAR INTERVENTION AND THERAPEUTICS 33 巻 ( 4 ) 頁： 393 - 394 2018年10月

Clinical Impact of Circulating Irisin on Classified Coronary Plaque Characteristics

Hirayama Kenshi, Ishii Hideki, Kikuchi Ryosuke, Suzuki Susumu, Aoki Toshijiro, Harada Kazuhiro, Sumi Takuya, Negishi Yosuke, Shibata Yohei, Tatami Yosuke, Tanaka Akihito, Murohara Toyoaki

JOURNAL OF APPLIED LABORATORY MEDICINE 3 巻 ( 1 ) 頁： 79 - 88 2018年7月

記述言語：日本語出版者・発行元：The journal of applied laboratory medicine

BACKGROUND: Myokines are hormones secreted by skeletal muscles during physical activity. Low myokine levels may contribute to metabolic dysfunction and cardiovascular disorders. Irisin, a newly identified myokine, has been the focus of recent research. The aim of the present study was to analyze the association between circulating irisin levels and tissue characteristics of nonculprit left main coronary artery (LMCA) plaques with the use of integrated backscatter (IB) intravascular ultrasound (IVUS). METHODS: This observational study enrolled 55 Japanese patients following successful percutaneous coronary intervention for lesions in the left anterior descending arteries or left circumflex arteries. Circulating myokine levels, including myostatin, brain-derived neurotrophic factor, and irisin, were measured by an enzyme-linked immunosorbent assay. Tissue characteristics of LMCA plaque were evaluated by IB-IVUS. RESULTS: Circulating irisin levels were negatively associated with percent lipid volume (%LV) [r = -0.31 (95% CI, -2.52 to -0.21), P = 0.02] and positively associated with percent fibrous volume (%FV) [r = 0.32 (95% CI, 0.22-2.20), P = 0.02]. The optimal cutoff value of circulating irisin for the prediction of lipid-rich LMCA plaques was 6.02 μg/mL [area under the curve = 0.713, P < 0.01 (95% CI, 0.58-0.85)]. Multivariate linear regression analysis identified circulating irisin levels as independent predictors for %LV and %FV of the LMCA [β = -0.29 (95% CI, -2.53 to -0.07), P = 0.04 and β = 0.30 (95% CI, 0.10-2.23), P = 0.03, respectively]. CONCLUSIONS: Circulating irisin levels are significantly associated with tissue characteristics of nonculprit LMCA plaques.

DOI： 10.1373/jalm.2017.025296

Association between the ratio of anti-angiogenic isoform of VEGF-A to total VEGF-A and adverse clinical outcomes in patients after acute myocardial infarction

Harada Kazuhiro, Kikuchi Ryosuke, Ishii Hideki, Shibata Yohei, Suzuki Susumu, Tanaka Akihito, Suzuki Atsuo, Hirayama Kenshi, Murohara Toyoaki

IJC HEART & VASCULATURE 19 巻頁： 3 - 7 2018年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：IJC Heart and Vasculature

Background: Vascular endothelial growth factor-A (VEGF-A) promotes neovascularization and is attracting considerable attention as a remarkable risk factor in patients after acute myocardial infarction (AMI). In contrast, the association between VEGF-A165b, which is the main anti-angiogenic isoform of VEGF-A, and adverse clinical outcomes after AMI remains unclear. The present study aimed to investigate the association between serum VEGF-A165b and major adverse cardiac and cerebrovascular events (MACCEs) after percutaneous coronary intervention (PCI) for AMI. Methods: We evaluated 23 patients with AMI who underwent primary percutaneous coronary intervention. VEGF-A and VEGF-A165b levels were measured on admission (day 1) and at days 3, 7, and 30 after PCI. Results: The levels of total VEGF-A tended to be lower, while the ratio of VEGF-A165b to total VEGF-A tended to be higher in patients with MACCEs than in those without. The patients with a high ratio of VEGF-A165b to total VEGF-A had a significantly higher risk of MACCEs using the cut-off values for MACCEs at day 30 after PCI (0.87 vs. 0.25, log-rank test, p = 0.0058). Conclusion: The assessment of VEGF-A165b combined with VEGF-A may be a valuable screening tool for predicting MACCEs in clinical practice.

DOI： 10.1016/j.ijcha.2018.03.004

Impact of high-density lipoprotein 3 cholesterol subfraction on periprocedural myocardial injury in patients who underwent elective percutaneous coronary intervention

Harada Kazuhiro, Kikuchi Ryosuke, Suzuki Susumu, Tanaka Akihito, Aoki Toshijiro, Iwakawa Naoki, Kojima Hiroki, Hirayama Kenshi, Mitsuda Takayuki, Sumi Takuya, Negishi Yosuke, Ishii Hideki, Murohara Toyoaki

LIPIDS IN HEALTH AND DISEASE 17 巻 ( 1 ) 頁： 21 2018年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Lipids in Health and Disease

Background: Periprocedural myocardial injury (PMI) is a major complication of percutaneous coronary intervention (PCI) and is associated with atherosclerotic coronary plaque and worse clinical outcomes. High-density lipoprotein cholesterol (HDL-C) is a protective factor for cardiovascular disease. However, the role of HDL-C subfractions, such as HDL2 cholesterol (HDL2-C) or HDL3 cholesterol (HDL3-C), in cardiovascular disease remains unclear. The purpose of the study was to investigate the relationship between HDL2-C and HDL3-C subfractions and the incidence of PMI in patients who underwent elective PCI. Methods: We enrolled 129 patients who underwent elective PCI for stable angina pectoris. PMI was defined as an increase in high-sensitivity troponin T levels > 5 times the upper normal limit (> 0.070 ng/mL) at 24 h after PCI. Serum HDL-C subfractions (HDL2-C and HDL3-C) were assessed using ultracentrifugation in patients with and those without PMI. Results: HDL3-C levels were significantly lower in patients with PMI than in those without (15.1 ± 3.0 mg/dL vs. 16.4 ± 2.9 mg/dL, p = 0.016) and had an independent and inverse association with PMI (odds ratio, 0.86; 95% confidence interval, 0.74-0.99; p = 0.038). When divided by the cut-off value of HDL3-C for PMI (14.3 mg/dL), the incidence of PMI was significantly higher in low HDL3-C patients than in high HDL3-C patients (51.2% vs. 30.2%, p = 0.020). Conclusions: HDL3-C was an independent inverse predictor of PMI in patients who underwent elective PCI.

DOI： 10.1186/s12944-018-0670-3

Comparison of mid-term clinical outcomes after treatment of ostial right coronary artery lesions with early and new generation drug-eluting stents: Insights from an international multicenter registry. 査読有り

Mitomo S, Jabbour RJ, Watanabe Y, Mangieri A, Ancona M, Regazzoli D, Tanaka A, Nakajima A, Naganuma T, Giannini F, Latib A, Nakamura S, Colombo A

International journal of cardiology 254 巻頁： 53 - 58 2018年

Impact of post-dilatation on longitudinal stent elongation: An in vitro study

Sumi Takuya, Ishii Hideki, Tanaka Akihito, Suzuki Susumu, Kojima Hiroki, Iwakawa Naoki, Aoki Toshijiro, Hirayama Kenshi, Mitsuda Takayuki, Harada Kazuhiro, Negishi Yosuke, Ota Tomoyuki, Kada Kenji, Murohara Toyoaki

JOURNAL OF CARDIOLOGY 71 巻 ( 5-6 ) 頁： 464 - 470 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Cardiology

Objectives: To evaluate whether balloon inflation for post-dilatation causes longitudinal stent deformation (LSD). Methods and results: Two stents, sized 2.5 mm × 28 mm and 3.5 mm × 28 mm (Nobori ® , biodegradable polymer biolimus-eluting stent; Ultimaster ® , biodegradable polymer sirolimus-eluting stent; Terumo Co., Tokyo, Japan), were deployed at nominal pressure in straight and tapered silicon vessel models. Then, post-dilatation was performed in two ways: dilatation from the distal (D-P group) or proximal (P-D group) side of the stent. Microscopic findings showed that the stents were elongated during every step of the procedure regardless of the post-dilatation method and type of vessel model. The D-P group showed linear elongation during each step of post-dilatation (straight model: 28.7 ± 0.3 mm vs. 29.9 ± 0.3 mm, p = 0.002; tapered model: 28.0 ± 0.1 mm vs. 29.9 ± 0.1 mm, p < 0.001). In contrast, in the P-D group, the most significant change was observed in the first step of post-dilatation and only slight changes were observed thereafter (straight model: 28.6 ± 0.1 mm vs. 29.5 ± 0.1 mm, p < 0.001; tapered model: 28.2 ± 0.1 mm vs. 29.5 ± 0.1 mm, p < 0.001). Optical frequency domain imaging analysis showed that the frequency of stent strut malapposition was positively correlated with the percentage change in stent length (r = 0.74, p < 0.0001). Conclusion: LSD was observed during every step of post-dilatation in both the straight and tapered vessel models. However, some differences were observed between the D-P and P-D groups. Minimizing stent strut malapposition may reduce the risk of LSD.

DOI： 10.1016/j.jjcc.2017.11.003

Different Behavior of Bioresorbable Vascular Scaffold and Metallic Stent With Positive Vessel Remodeling. 査読有り

Mitomo S, Regazzoli D, Candilio L, Tanaka A, Latib A, Colombo A

Circulation journal : official journal of the Japanese Circulation Society 82 巻 ( 6 ) 頁： 1716 - 1717 2018年

A comparison of the fully repositionable and retrievable Boston Lotus and direct flow medical valves for the treatment of severe aortic stenosis: A single center experience. 査読有り

Giannini F, Latib A, Montorfano M, Ruparelia N, Romano V, Longoni M, Ferri L, Jabbour R, Mangieri A, Regazzoli D, Ancona M, Buzzatti N, Azzalini L, Tanaka A, Agricola E, Chieffo A, Alfieri O, Colombo A

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 91 巻 ( 5 ) 頁： 966 - 974 2018年

Bioresorbable vascular scaffold versus everolimus-eluting stents or drug eluting balloon for the treatment of coronary in-stent restenosis: 1-Year follow-up of a propensity score matching comparison (the BIORESOLVE-ISR Study). 査読有り

Moscarella E, Tanaka A, Ielasi A, Cortese B, Coscarelli S, De Angelis MC, Piraino D, Latib A, Grigis G, Bianchi R, Buccheri D, Calabrò P, Tespili M, Silva Orrego P, Colombo A, Varricchio A

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 92 巻 ( 4 ) 頁： 668 - 677 2018年

Predictors of Advanced Conduction Disturbances Requiring a Late (≥48 H) Permanent Pacemaker Following Transcatheter Aortic Valve Replacement.

Mangieri A, Lanzillo G, Bertoldi L, Jabbour RJ, Regazzoli D, Ancona MB, Tanaka A, Mitomo S, Garducci S, Montalto C, Pagnesi M, Giannini F, Giglio M, Montorfano M, Chieffo A, Rodès-Cabau J, Monaco F, Paglino G, Della Bella P, Colombo A, Latib A

JACC. Cardiovascular interventions 11 巻 ( 15 ) 頁： 1519 - 1526 2018年

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