研究者詳細 - 田中　哲人

論文 - 田中　哲人

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Positive Vessel Remodeling and Appearance of Pulsatile Wall Motion at Long-Term Follow-Up After Bioresorbable Scaffold Implantation in a Chronic Total Occlusion. 査読有り

Tanaka A, Ruparelia N, Kawamoto H, Latib A, Colombo A

JACC. Cardiovascular interventions 8 巻 ( 12 ) 頁： 1635 - 7 2015年

Practical Approach to Evaluate Asymptomatic Coronary Artery Disease in End-Stage Renal Disease Patients at the Initiation of Dialysis 査読有り

Tanaka Akihito, Sakakibara Masaki, Asada Hiroaki, Tanaka Toshikazu, Ishii Hideki, Murohara Toyoaki

THERAPEUTIC APHERESIS AND DIALYSIS 18 巻 ( 2 ) 頁： 167 - 173 2014年

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Therapeutic Apheresis and Dialysis

The high prevalence of significant asymptomatic coronary artery disease (CAD) has been reported in patients with end-stage renal disease (ESRD) at the initiation of dialysis. However, the approach to evaluate asymptomatic CAD for these patients has not been established. The aim of this study is to assess the applicability of our practical approach at the initiation of dialysis. We prospectively enrolled 182 consecutive ESRD patients who initiated dialysis. After echocardiography as primary screening, pharmacologic stress thallium-201 scintigraphy and/or coronary angiography (CAG) were performed to diagnose CAD. The patients were classified into two groups: those with coronary artery stenosis by CAG (CAD+ group), those without coronary artery stenosis by CAG or with negative scintigraphy examination (CAD- group). Of the eligible 93 patients without the history of CAD, 22 patients were allocated to the CAD+ group (18 of 26 patients with abnormal echocardiography and 4 of 13 patients with positive scintigraphy examination) and 71 patients to the CAD- group. Patients were followed up for an average of 520±304 days. The event-free survival rate of major adverse cardiac events was significantly lower in the CAD+ group than in the CAD- group (P<0.001). There was no cardiovascular event including major adverse cardiac events, unstable angina, coronary revascularization or stroke in the CAD- group during the first year of dialysis. Patients without CAD diagnosed by our approach had favorable clinical outcomes. Our approach may be useful for screening of occult CAD in ESRD patients at the initiation of dialysis. © 2014 International Society for Apheresis.

DOI： 10.1111/1744-9987.12098

Temporary Adjunctive Cilostazol vs Clopidogrel Loading for ST-segment Elevation Acute Myocardial Infarction 査読有り

Tanaka Akihito, Ishii Hideki, Sakakibara Masaki, Okumura Satoshi, Jinno Yasushi, Okada Koji, Suzuki Susumu, Inoue Yosuke, Murohara Toyoaki

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS 14 巻 ( 2 ) 頁： 131 - 136 2014年

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Journal of Cardiovascular Drugs

Background: Clopidogrel loading is a standard method to achieve rapid platelet inhibition and prevent thrombotic events. At the current time, little information is available to determine the effect of adjunctive cilostazol compared with clopidogrel loading. Methods: We retrospectively analyzed 212 patients undergoing primary percutaneous coronary intervention with drug-eluting stents for ST-segment elevation acute myocardial infarction. All patients were administered aspirin (100 mg once a day) and clopidogrel (75 mg once a day). The patients were divided into two groups according to the presence (loading group, n = 100) or absence (cilostazol group, n = 112) of clopidogrel loading (300 mg). Patients in the cilostazol group were administered adjunctive cilostazol (100 mg twice a day) in place of clopidogrel loading. Patient characteristics, medications, and 30-day clinical outcomes were examined. Results: The mean duration of cilostazol administration in the cilostazol group was 6.2 ± 4.9 days from the time of primary coronary intervention. No significant difference was observed in major adverse cardiac events (cardiac death, definite stent thrombosis, and non-fatal myocardial infarction) between the loading group and the cilostazol group (9/100; 9.0 vs. 8/112; 7.1 %, p = 0.62). Definite stent thrombosis was observed for two patients in the loading group and one patient in the cilostazol group. The occurrence ratio of bleeding events did not differ significantly between the two groups (9.0 vs. 5.4 %, p = 0.30). Conclusion: There was no significant difference in the incidence of major adverse cardiac events between temporary adjunctive cilostazol treatment and clopidogrel loading in ST-segment elevation acute myocardial infarction patients. Our findings suggest one potential of cilostazol. © 2014 Springer International Publishing.

DOI： 10.1007/s40256-013-0059-7

Impact of diabetic retinopathy on late cardiac events after percutaneous coronary intervention 査読有り

Tanaka Akihito, Ishii Hideki, Tatami Yosuke, Shibata Yohei, Osugi Naohiro, Ota Tomoyuki, Okumura Satoshi, Suzuki Susumu, Inoue Yosuke, Murohara Toyoaki

JOURNAL OF CARDIOLOGY 64 巻 ( 3 ) 頁： 175 - 178 2014年

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Cardiology

Background: Diabetic retinopathy has been identified as a predictor of cardiovascular events and heart failure in patients with diabetes mellitus (DM). This study aimed to assess the impact of diabetic retinopathy on the incidence of late cardiac events following percutaneous coronary intervention. Methods: We enrolled 88 consecutive DM patients who underwent elective percutaneous coronary intervention and whose ophthalmologic records were available. Patients were divided into 2 groups: those with diabetic retinopathy (DR+ group; n = 47), and those without diabetic retinopathy (DR- group; n = 41). We examined the incidence of major adverse cardiac events (MACE) including cardiac death, myocardial infarction, and acute heart failure requiring emergency admission over a period of up to 5 years. Results: Patients in the DR+ group were likely to have a lower estimated glomerular filtration rate. Kaplan-Meier analysis showed that the event-free survival rates for all MACE, myocardial infarction, and heart failure were significantly lower in the DR+ group than in the DR- group (p = 0.002, p = 0.025, and p = 0.022, respectively). Multivariate Cox proportional hazards analysis indicated that the presence of DR was a significant predictor of MACE (hazard ratio: 8.7; 95% CI: 1.1-69.8, p = 0.042). Conclusion: The presence of DR might be a useful predictor of late cardiac events following percutaneous coronary intervention.

DOI： 10.1016/j.jjcc.2013.12.006

The risk of adverse cardiac events following minor surgery under discontinuation of all antiplatelet therapy in patients with prior drug-eluting stent implantation 査読有り

Tanaka Akihito, Sakakibara Masaki, Ishii Hideki, Okumura Satoshi, Suzuki Susumu, Inoue Yosuke, Jinno Yasushi, Okada Koji, Murohara Toyoaki

INTERNATIONAL JOURNAL OF CARDIOLOGY 172 巻 ( 1 ) 頁： E125 - E126 2014年

Evaluation for hypoperfusion distal to arteriovenous vascular access using skin perfusion pressure in fingers 査読有り

Tanaka Akihito, Sakakibara Masaki, Nishimura Hayato, Asano Marina, Kariya Tetsuyoshi, Masamoto Daijiro, Mizutani Makoto, Ishii Hideki, Murohara Toyoaki

JOURNAL OF VASCULAR ACCESS 15 巻 ( 1 ) 頁： 29 - 32 2014年

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Vascular Access

Purpose: The usefulness of skin perfusion pressure (SPP) measurement in the assessment of critical ischemia of the lower limb has previously been established. This study investigated whether finger SPP measurement is useful to evaluate hypoperfusion distal to arteriovenous vascular access in dialysis patients. Methods: Seventeen asymptomatic hemodialysis patients with upper extremity arteriovenous access and 17 non-dialysis control patients were prospectively examined. SPP in the thumb, the middle finger and the little finger of both hands was measured. The bilateral difference of the mean SPP of the three fingers was evaluated. Results: The mean difference of SPP between the contralateral and the arteriovenous access sides among hemodialysis patients (33±2 5 mmHg) was significantly larger than the mean difference of SPP between the left and the right hands among control patients (1.0±6.0 mmHg, p<0.01). Conclusions: This report shows the potential usefulness of SPP measurement to evaluate hypoperfusion distal to arteriovenous vascular access. © 2013 Wichtig Editore.

DOI： 10.5301/jva.5000170

Coronary Subclavian Steal from a Left Internal Thoracic Artery Coronary Bypass Graft due to Ipsilateral Subclavian Artery Stenosis and an Arteriovenous Graft in a Hemodialysis Patient with Left Vertebral Artery Occlusion

Tanaka Akihito, Sakakibara Masaki, Okada Koji, Jinno Yasushi, Ishii Hideki, Murohara Toyoaki

Internal Medicine 52 巻 ( 11 ) 頁： 1195 - 1198 2013年

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Japanese Society of Internal Medicine

Coronary subclavian steal syndrome is an unusual cause of myocardial ischemia, secondary to a reversed blood flow in patients with patent internal thoracic artery coronary bypass grafts. The causes of coronary subclavian steal are either ipsilateral subclavian artery stenosis or upper extremity arteriovenous hemodialysis fistula formation or both. This report involves a 68-year-old woman with left vertebral artery occlusion who developed severe coronary steal in the absence of vertebral subclavian steal due to left subclavian artery stenosis and an arteriovenous hemodialysis graft.<br>

DOI： 10.2169/internalmedicine.52.8950

Treatment of sirolimus-eluting stent restenosis: additional stent, balloon angioplasty, and coronary artery bypass graft. 査読有り国際誌

Ishikawa K, Aoyama Y, Kato K, Tanaka A, Hiramatsu M, Ajioka M, Kamiya H, Tanaka T, Hirayama H

Journal of cardiac surgery 28 巻 ( 2 ) 頁： 97 - 101 2013年

Migration of fractured renal artery stent. 査読有り

Tanaka A, Takahashi S, Saito S

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 77 巻 ( 2 ) 頁： 305 - 7 2011年

Perioperative intra-aortic balloon pumping and staged coronary intervention for a patient with concurrent coronary artery disease and cancer

Ishikawa, K., Tanaka, A., Kawase, H., Tanaka, T.

Acta Cardiologica Sinica 27 巻 ( 4 ) 2011年

Short and mid-term outcomes of coronary intervention with the MULTI-LINK vision™ stent

Tanaka, A., Suzuki, Y., Suzuki, N., Hirai, T., Yasuda, N., Miki, K., Fujita, M., Morishita, Y., Yanagisawa, S., Kawase, H., Tanaka, T.

Japanese Journal of Interventional Cardiology 24 巻 ( 3 ) 2009年

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