所属
医学部附属病院 産科婦人科 講師
大学院担当
大学院医学系研究科
職名
講師
ウシダ タカフミ
牛田 貴文
USHIDA Takafumi
学位 1
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医学博士 （ 2017年7月 名古屋大学 ）
研究キーワード 4
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エピジェネティクス
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メタボリック症候群
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心血管障害
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妊娠高血圧腎症, 母体炎症
研究分野 2
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ライフサイエンス / 産婦人科学
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ライフサイエンス / 胎児医学、小児成育学
現在の研究課題とSDGs 2
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妊娠高血圧腎症妊婦から出生した児におけるDOHaD仮説の検証と早期介入への戦略
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妊娠高血圧腎症と将来の心血管障害発症との関連性～エピジェネティクスの観点より
経歴 3
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名古屋大学 産婦人科 助教
2017年4月 - 現在
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名古屋大学 産婦人科
2013年4月 - 2017年3月
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愛知県厚生農業協同組合連合会 安城更生病院 産婦人科
2006年4月 - 2013年3月
学歴 1
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名古屋大学 医学部 医学科
1999年4月 - 2006年3月
国名： 日本国
所属学協会 4
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日本産科婦人科学会 指導医
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日本周産期・新生児医学会 指導医
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日本妊娠高血圧学会 総務役員
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日本胎盤学会
委員歴 1
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日本妊娠高血圧学会 総務委員
2018年4月 - 現在
団体区分：学協会
受賞 3
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学術集会長賞
2019年11月 日本産科麻酔学会
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学術奨励賞
2018年12月 尚和会
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Y.W. Loke New Investigator Travel Award
2014年9月 International Federation of Placenta Associations
論文 79
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Mortality and neurological outcomes in extremely and very preterm infants born to mothers with hypertensive disorders of pregnancy 査読有り
Nakamura Noriyuki, Ushida Takafumi, Nakatochi Masahiro, Kobayashi Yumiko, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Hayakawa Masahiro, Kajiyama Hiroaki, Kikkawa Fumitaka, Kotani Tomomi
SCIENTIFIC REPORTS 11 巻 ( 1 ) 2021年1月
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Antenatal corticosteroids and preterm offspring outcomes in hypertensive disorders of pregnancy: A Japanese cohort study 査読有り
Ushida Takafumi, Kotani Tomomi, Hayakawa Masahiro, Hirakawa Akihiro, Sadachi Ryo, Nakamura Noriyuki, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Kikkawa Fumitaka
SCIENTIFIC REPORTS 10 巻 ( 1 ) 2020年6月
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Antenatal Corticosteroids and Outcomes in Preterm Twins 査読有り
Ushida Takafumi, Kotani Tomomi, Sadachi Ryo, Hirakawa Akihiro, Hayakawa Masahiro, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Kikkawa Fumitaka
OBSTETRICS AND GYNECOLOGY 135 巻 ( 6 ) 頁： 1387 - 1397 2020年6月
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Persistence of risk factors associated with maternal cardiovascular disease following aberrant inflammation in rat pregnancy 査読有り 国際共著
Ushida Takafumi, Macdonald-Goodfellow Shannyn K., Quadri Allegra, Tse M. Yat, Winn Louise M., Pang Stephen C., Adams Michael A., Kotani Tomomi, Kikkawa Fumitaka, Graham Charles H.
BIOLOGY OF REPRODUCTION 97 巻 ( 1 ) 頁： 143-152 2017年7月
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Ohori, Y; Imai, K; Tano, S; Owaki, T; Miki, R; Nozaki, Y; Ushida, T; Kajiyama, H; Kotani, T
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 2024年1月
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Matsuo, S; Ushida, T; Tano, S; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T
REPRODUCTIVE BIOMEDICINE ONLINE 47 巻 ( 6 ) 頁： 103331 2023年12月
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Ushida, T; Nakamura, N; Katsuki, S; Mizutani, H; Iitani, Y; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T
HYPERTENSION RESEARCH 46 巻 ( 12 ) 頁： 2583 - 2592 2023年12月
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Predictive performance of Shock Index for postpartum hemorrhage during cesarean delivery.
Mizutani H, Ushida T, Ozeki K, Tano S, Iitani Y, Imai K, Nishiwaki K, Kajiyama H, Kotani T
International journal of obstetric anesthesia 頁： 103957 2023年11月
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Interleukin-17A stimulation induces alterations in Microglial microRNA expression profiles
Iitani, Y; Miki, R; Imai, K; Fuma, K; Ushida, T; Tano, S; Yoshida, K; Yokoi, A; Kajiyama, H; Kotani, T
PEDIATRIC RESEARCH 95 巻 ( 1 ) 頁： 167 - 173 2023年9月
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Nosaka, R; Ushida, T; Kidokoro, H; Kawaguchi, M; Shiraki, A; Iitani, Y; Imai, K; Nakamura, N; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T
ARCHIVES OF GYNECOLOGY AND OBSTETRICS 2023年5月
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Antenatal corticosteroids-to-delivery interval associates cord blood S100B levels
Fuma Kazuya, Kotani Tomomi, Ushida Takafumi, Imai Kenji, Iitani Yukako, Nakamura Noriyuki, Miki Rika, Katsuki Satoru, Kinoshita Fumie, Sato Yoshiaki, Hayakawa Masahiro, Kajiyama Hiroaki
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 49 巻 ( 4 ) 頁： 1129 - 1136 2023年2月
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Clinical significances of Bishop score and vaginal bleeding to controlled-release dinoprostone delivery system (PROPESS) efficacy for cervical ripening: A retrospective single-center study in Japan
Imai Kenji, Aoki Chieko, Tano Sho, Iitani Yukako, Nakamura Noriyuki, Ushida Takafumi, Kajiyama Hiroaki, Kotani Tomomi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 49 巻 ( 4 ) 頁： 1154 - 1160 2023年2月
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Trend changes in age-related body mass index gain after coronavirus disease 2019 pandemic in Japan: a multicenter retrospective cohort study
Tano Sho, Kotani Tomomi, Ushida Takafumi, Iitani Yukako, Imai Kenji, Kinoshita Fumie, Kajiyama Hiroaki
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 21 巻 ( 1 ) 頁： 7 2023年1月
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Prenatal diagnosis of distal 13q deletion syndrome in a fetus with esophageal atresia: a case report and review of the literature
Kotani Tomomi, Tsuda Hiroyuki, Ito Yumiko, Nakamura Noriyuki, Ushida Takafumi, Imai Kenji, Iitani Yukako, Fuma Kazuya, Muramatsu Yukako, Hayakawa Masahiro, Kajiyama Hiroaki
JOURNAL OF MEDICAL CASE REPORTS 16 巻 ( 1 ) 頁： 481 2022年12月
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Antenatal prediction models for outcomes of extremely and very preterm infants based on machine learning
Ushida Takafumi, Kotani Tomomi, Baba Joji, Imai Kenji, Moriyama Yoshinori, Nakano-Kobayashi Tomoko, Iitani Yukako, Nakamura Noriyuki, Hayakawa Masahiro, Kajiyama Hiroaki
ARCHIVES OF GYNECOLOGY AND OBSTETRICS 2022年12月
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A case of non-immune hydrops fetalis with maternal mirror syndrome diagnosed by trio-based exome sequencing: An autopsy case report and literature review
Tano Sho, Kotani Tomomi, Yoshihara Masato, Nakamura Noriyuki, Matsuo Seiko, Ushida Takafumi, Imai Kenji, Ito Miharu, Oka Yasuyoshi, Sato Emi, Hayashi Shin, Ogi Tomoo, Kajiyama Hiroaki
MOLECULAR GENETICS AND METABOLISM REPORTS 33 巻 頁： 100925 2022年12月
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Aberrant inflammation in rat pregnancy leads to cardiometabolic alterations in their offspring and intrauterine growth restriction in the F2 generation
Ushida Takafumi, Cotechini Tiziana, Protopapas Nicole, Atallah Aline, Collyer Charlotte, Toews Alexa J., Macdonald-Goodfellow Shannyn K., Tse M. Yat, Winn Louise M., Pang Stephen C., Adams Michael A., Othman Maha, Kotani Tomomi, Kajiyama Hiroaki, Graham Charles H.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE 13 巻 ( 6 ) 頁： 706 - 718 2022年12月
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Antenatal corticosteroids and outcomes of small for gestational age infants born at 24-31 gestational weeks: a population-based propensity score matching analysis
Ushida Takafumi, Nakatochi Masahiro, Kobayashi Yumiko, Nakamura Noriyuki, Fuma Kazuya, Iitani Yukako, Imai Kenji, Sato Yoshiaki, Hayakawa Masahiro, Kajiyama Hiroaki, Kotani Tomomi, Japan Neonatal Research Network Of
ARCHIVES OF GYNECOLOGY AND OBSTETRICS 2022年11月
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Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells
Aoki Chieko, Imai Kenji, Mizutani Teruyuki, Sugiyama Daisuke, Miki Rika, Koya Yoshihiro, Kobayashi Tomoko, Ushida Takafumi, Iitani Yukako, Nakamura Noriyuki, Owaki Taro, Nishikawa Hiroyoshi, Toyokuni Shinya, Kajiyama Hiroaki, Kotani Tomomi
LIFE SCIENCES 308 巻 頁： 120955 2022年11月
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5p deletion with congenital diaphragmatic hernia: a case report
Kotani Tomomi, Ushida Takafumi, Nakamura Noriyuki, Imai Kenji, Iitani Yukako, Tano Sho, Iwagaki Shigenori, Takahashi Yuichiro, Ito Miharu, Hayakawa Masahiro, Kajiyama Hiroaki
JOURNAL OF MEDICAL CASE REPORTS 16 巻 ( 1 ) 頁： 390 2022年10月
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Optimal annual body mass index change for preventing spontaneous preterm birth in a subsequent pregnancy
Tano Sho, Kotani Tomomi, Ushida Takafumi, Yoshihara Masato, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Iitani Yukako, Kinoshita Fumie, Yoshida Shigeru, Yamashita Mamoru, Kishigami Yasuyuki, Oguchi Hidenori, Kajiyama Hiroaki
SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 17502 2022年10月
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DEVELOPING OF A NOVEL THERAPEUTIC AGENT FOR FGR THROUGH DRUG REPOSITIONING
Tano Sho, Kotani Tomomi, Ushida Takafumi, Nakamura Noriyuki, Iitani Yukako, Yoshihara Masato, Imai Kenji, Kajiyama Hiroaki
PLACENTA 128 巻 頁： 124 - 124 2022年10月
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Severe Congenital Diaphragmatic Hernia With Trisomy 9: A Case Report and Review of the Literature
Fuma Kazuya, Kotani Tomomi, Nakamura Noriyuki, Ushida Takafumi, Kajiyama Hiroaki
CUREUS JOURNAL OF MEDICAL SCIENCE 14 巻 ( 8 ) 頁： e28395 2022年8月
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Impact of hypertensive disorders of pregnancy on respiratory outcomes in extremely and very preterm infants: A population-based study in Japan
Ushida Takafumi, Nakamura Noriyuki, Nakatochi Masahiro, Kobayashi Yumiko, Sato Yoshiaki, Iitani Yukako, Imai Kenji, Nakano-Kobayashi Tomoko, Hayakawa Masahiro, Kajiyama Hiroaki, Kotani Tomomi
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH 29 巻 頁： 54 - 60 2022年8月
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Machine learning prediction models for postpartum depression: A multicenter study in Japan
Matsuo Seiko, Ushida Takafumi, Emoto Ryo, Moriyama Yoshinori, Iitani Yukako, Nakamura Noriyuki, Imai Kenji, Nakano-Kobayashi Tomoko, Yoshida Shigeru, Yamashita Mamoru, Matsui Shigeyuki, Kajiyama Hiroaki, Kotani Tomomi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 48 巻 ( 7 ) 頁： 1775 - 1785 2022年7月
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Reassessing the duration of each stage of labor and their relation to postpartum hemorrhage in the current Japanese population
Ushida Takafumi, Matsuo Seiko, Nakamura Noriyuki, Iitani Yukako, Imai Kenji, Nakano-Kobayashi Tomoko, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 48 巻 ( 7 ) 頁： 1760 - 1767 2022年7月
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The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia
Aoki Chieko, Imai Kenji, Owaki Taro, Kobayashi-Nakano Tomoko, Ushida Takafumi, Iitani Yukako, Nakamura Noriyuki, Kajiyama Hiroaki, Kotani Tomomi
MEDICINA-LITHUANIA 58 巻 ( 6 ) 2022年6月
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Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb)
Maki Shintaro, Tanaka Hiroaki, Takakura Sho, Nii Masafumi, Tanaka Kayo, Ogura Toru, Kotera Mayumi, Nishimura Yuki, Tamaru Satoshi, Ushida Takafumi, Tanaka Yasuhiro, Kikuchi Norihiko, Kinjo Tadatsugu, Kawamura Hiroshi, Takano Mayumi, Nakamura Koji, Suga Sachie, Kasai Michi, Yasui Osamu, Nagao Kenji, Maegawa Yuka, Kotani Tomomi, Endo Masayuki, Yasuhi Ichiro, Aoki Shigeru, Aoki Yoichi, Yoshida Yoshio, Nakata Masahiko, Sekizawa Akihiko, Ikeda Tomoaki
BMJ OPEN 12 巻 ( 6 ) 頁： e054925 2022年6月
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Intrauterine exposure to hypertensive disorders of pregnancy and postnatal growth in extremely and very preterm infants
Ushida Takafumi, Kotani Tomomi, Nakatochi Masahiro, Kobayashi Yumiko, Nakamura Noriyuki, Imai Kenji, Iitani Yukako, Nakano-Kobayashi Tomoko, Hayakawa Masahiro, Kajiyama Hiroaki
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH 28 巻 頁： 174 - 179 2022年6月
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Pregnancy Outcomes in Women with Thyroid Diseases.
Kotani T, Imai K, Ushida T, Moriyama Y, Nakano-Kobayashi T, Osuka S, Tsuda H, Sumigama S, Yamamoto E, Kinoshita F, Hirakawa A, Iwase A, Kikkawa F, Kajiyama H
JMA journal 5 巻 ( 2 ) 頁： 216 - 223 2022年4月
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Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase
Koike Hiroshi, Nishida Yoshihiro, Shinomura Tamayuki, Ohkawara Bisei, Ohno Kinji, Zhuo Lisheng, Kimata Koji, Ushida Takahiro, Imagama Shiro
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 巻 ( 8 ) 2022年4月
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Annual Body Mass Index Gain and Risk of Gestational Diabetes Mellitus in a Subsequent Pregnancy
Tano Sho, Kotani Tomomi, Ushida Takafumi, Yoshihara Masato, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Iitani Yukako, Kinoshita Fumie, Yoshida Shigeru, Yamashita Mamoru, Kishigami Yasuyuki, Oguchi Hidenori, Kajiyama Hiroaki
FRONTIERS IN ENDOCRINOLOGY 13 巻 頁： 815390 2022年3月
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Assessment of placental abruption with diffusion-weighted imaging
Mizutani Teruyuki, Kotani Tomomi, Kato Noriko, Imai Kenji, Ushida Takafumi, Nakano-Kobayashi Tomoko, Kinoshita Yoshimi, Ito Masato, Kinoshita Fumie, Yamamuro Osamu, Kajiyama Hiroaki
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 2022年2月
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Pre-pregnancy sleep duration and postpartum depression: a multicenter study in Japan
Matsuo Seiko, Ushida Takafumi, Iitani Yukako, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi
ARCHIVES OF WOMENS MENTAL HEALTH 25 巻 ( 1 ) 頁： 181 - 189 2022年2月
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Prevalence and risk factors of labor-onset hypertension: A multicenter study in Japan
Ushida Takafumi, Kotani Tomomi, Imai Kenji, Nakano-Kobayashi Tomoko, Iitani Yukako, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH 26 巻 頁： 48 - 53 2021年12月
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Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study
Katsuki Satoru, Ushida Takafumi, Kidokoro Hiroyuki, Nakamura Noriyuki, Iitani Yukako, Fuma Kazuya, Imai Kenji, Nakano-Kobayashi Tomoko, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi
EARLY HUMAN DEVELOPMENT 163 巻 頁： 105479 2021年12月
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Annual body mass index gain and risk of hypertensive disorders of pregnancy in a subsequent pregnancy
Tano Sho, Kotani Tomomi, Ushida Takafumi, Yoshihara Masato, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Iitani Yukako, Kinoshita Fumie, Yoshida Shigeru, Yamashita Mamoru, Kishigami Yasuyuki, Oguchi Hidenori, Kajiyama Hiroaki
SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 22519 2021年11月
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Manual removal of the placenta and postpartum hemorrhage: A multicenter retrospective study
Fujita Kei, Ushida Takafumi, Imai Kenji, Nakano-Kobayashi Tomoko, Iitani Yukako, Matsuo Seiko, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 47 巻 ( 11 ) 頁： 3867 - 3874 2021年11月
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Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction
Nomoto Masataka, Kotani Tomomi, Miki Rika, Ushida Takafumi, Imai Kenji, Iitani Yukako, Tano Sho, Wang Jingwen, Moriyama Yoshinori, Kobayashi Tomoko, Mimura Nobuko, Iriyama Takayuki, Kikkawa Fumitaka, Kajiyama Hiroaki
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 69 巻 ( 3 ) 頁： 280 - 285 2021年11月
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TRANSGENERATIONAL EFFECTS OF ABERRANT INFLAMMATION IN RAT PREGNANCY
Atallah Aline, Ushida Takafumi, Protopapas Nicole, Macdonald-Goodfellow Shannyn, Graham Charles, Cotechini Tiziana
PLACENTA 112 巻 頁： E39 - E39 2021年9月
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Current Issues within the Perinatal Mental Health Care System in Aichi Prefecture, Japan: A Cross-Sectional Questionnaire Survey
Fujita Kei, Kotani Tomomi, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Kobayashi-Nakano Tomoko, Kato Noriko, Kano Takeo, Kikkawa Fumitaka, Kajiyama Hiroaki
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 18 巻 ( 17 ) 2021年9月
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Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia
Miura Mayo, Imai Kenji, Tsuda Hiroyuki, Miki Rika, Tano Sho, Ito Yumiko, Hirako-Takamura Shima, Moriyama Yoshinori, Ushida Takafumi, Iitani Yukako, Nakano-Kobayashi Tomoko, Toyokuni Shinya, Kajiyama Hiroaki, Kotani Tomomi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 巻 ( 17 ) 2021年9月
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Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study
Ushida Takafumi, Kidokoro Hiroyuki, Nakamura Noriyuki, Katsuki Satoru, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH 25 巻 頁： 143 - 149 2021年8月
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Antenatal prediction models for short- and medium-term outcomes in preterm infants
Ushida Takafumi, Moriyama Yoshinori, Nakatochi Masahiro, Kobayashi Yumiko, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Hayakawa Masahiro, Kajiyama Hiroaki, Kotani Tomomi
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 100 巻 ( 6 ) 頁： 1089 - 1096 2021年6月
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Platelet counts during normal pregnancies and pregnancies complicated with hypertensive disorders
Ushida Takafumi, Kotani Tomomi, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Kinoshita Fumie, Nakamura Noriyuki, Iitani Yukako, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH 24 巻 頁： 73 - 78 2021年6月
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Postpartum alterations following inflammation in rat pregnancy: a discovery proteomic analysis
Ushida Takafumi, Kotani Tomomi, Moriyama Yoshinori, Hindmarch Charles C. T., Cotechini Tiziana, Imai Kenji, Nakano-Kobayashi Tomoko, Kajiyama Hiroaki, Graham Charles H.
REPRODUCTION 161 巻 ( 5 ) 頁： 513 - 522 2021年5月
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Assessment of myocardial performance index in late-onset fetal growth restriction
Tran Thao Nguyen Nguyen, Kotani Tomomi, Imai Kenji, Ushida Takafumi, Moriyama Yoshinori, Kobayashi Tomoko, Niimi Kaoru, Sumigama Seiji, Yamamoto Eiko, Van Duc Vo, Minh Tam Le, Lam Huong Le, Dac Nguyen Nguyen, Vu Quoc Huy Nguyen, Quang Vinh Truong, Ngoc Thanh Cao, Kikkawa Fumitaka
NAGOYA JOURNAL OF MEDICAL SCIENCE 83 巻 ( 2 ) 頁： 259 - 268 2021年5月
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Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia 査読有り
Ito Yumiko, Tsuda Hiroyuki, Imai Kenji, Miki Rika, Miura Mayo, Tachi Asuka, Tano Sho, Hirako-Takamura Shima, Moriyama Yoshinori, Ushida Takafumi, Kobayashi Tomoko, Sumigama Seiji, Kajiyama Hiroaki, Kikkawa Fumitaka, Kotani Tomomi
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 700 巻 2021年3月
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Trisomy 5p with bilateral congenital diaphragmatic hernia: a case report
Nakamura Noriyuki, Ushida Takafumi, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Osuka Satoko, Goto Maki, Kajiyama Hiroaki, Asada Hideyuki, Hayakawa Masahiro, Kotani Tomomi
JOURNAL OF MEDICAL CASE REPORTS 15 巻 ( 1 ) 頁： 114 2021年3月
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Shock Index and Postpartum Hemorrhage in Vaginal Deliveries: A Multicenter Retrospective Study
Ushida Takafumi, Kotani Tomomi, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kikkawa Fumitaka
SHOCK 55 巻 ( 3 ) 頁： 332 - 337 2021年3月
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Maternal low birth weight and hypertensive disorders of pregnancy
Ushida Takafumi, Kotani Tomomi, Kinoshita Fumie, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH 23 巻 頁： 5 - 10 2021年3月
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Liver transaminase levels during pregnancy: a Japanese multicenter study 査読有り
Ushida Takafumi, Kotani Tomomi, Kinoshita Fumie, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 2021年2月
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Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage 査読有り
Owaki Taro, Imai Kenji, Miki Rika, Niwa Yuri, Kotani Tomomi, Nakano-Kobayashi Tomoko, Ushida Takafumi, Kajiyama Hiroaki
CYTOKINE 138 巻 2021年2月
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Forced expression of KIAA1199, a novel hyaluronidase, inhibits tumorigenicity of low-grade chondrosarcoma
Koike Hiroshi, Nishida Yoshihiro, Shinomura Tamayuki, Zhuo Lisheng, Hamada Shunsuke, Ikuta Kunihiro, Ito Kan, Kimata Koji, Ushida Takahiro, Ishiguro Naoki
JOURNAL OF ORTHOPAEDIC RESEARCH 38 巻 ( 9 ) 頁： 1942 - 1951 2020年9月
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A proteome signature of umbilical cord serum associated with congenital diaphragmatic hernia.
Tachi A, Moriyama Y, Tsuda H, Miki R, Ushida T, Miura M, Ito Y, Imai K, Nakano-Kobayashi T, Hayakawa M, Kikkawa F, Kotani T
Nagoya journal of medical science 82 巻 ( 2 ) 頁： 345 - 354 2020年5月
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Determination of the cytokine levels in fetal pleural effusion and their association with fetal/neonatal findings
Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Kobayashi Tomoko, Ushida Takafumi, Moriyama Yoshinori, Kikkawa Fumitaka
CYTOKINE 127 巻 2020年3月
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Adverse effects of endometriosis on pregnancy: a case-control study 査読有り
Miura Mayo, Ushida Takafumi, Imai Kenji, Wang Jingwen, Moriyama Yoshinori, Nakano-Kobayashi Tomoko, Osuka Satoko, Kikkawa Fumitaka, Kotani Tomomi
BMC PREGNANCY AND CHILDBIRTH 19 巻 ( 1 ) 2019年10月
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A pitfall in diagnosing fetal abdominal lymphangioma: A report of two cases 査読有り
Niwa Yuri, Imai Kenji, Kotani Tomomi, Nakano Tomoko, Ushida Takafumi, Moriyama Yoshinori, Kikkawa Fumitaka
JOURNAL OF CLINICAL ULTRASOUND 47 巻 ( 8 ) 頁： 494 - 496 2019年10月
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Feasibility of using a handheld tissue hardness meter to quantify uterine contractions and its clinical application for obstetric bleeding management 査読有り
Imai Kenji, Kotani Tomomi, Ushida Takafumi, Moriyama Yoshinori, Nakano Tomoko, Kikkawa Fumitaka
JOURNAL OF OBSTETRICS AND GYNAECOLOGY 39 巻 ( 6 ) 頁： 757 - 762 2019年8月
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ABERRANT INFLAMMATION IN RAT PREGNANCY CONTRIBUTES TO RISK FACTORS ASSOCIATED WITH CARDIOVASCULAR DISEASE AND PREGNANCY COMPLICATIONS IN SUBSEQUENT GENERATIONS
Protopapas Nicole, Ushida Takafumi, Macdonald-Goodfellow Shannyn K., Graham Charles H.
PLACENTA 83 巻 頁： E76 - E76 2019年8月
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Relationship between cytokine profiles of cord blood and cord S100B levels in preterm infants.
Niwa Y, Imai K, Kotani T, Miki R, Nakano T, Ushida T, Moriyama Y, Kikkawa F
Early human development 129 巻 頁： 65-70 2019年2月
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The role of E2F8 in the human placenta
Mizuno Masako, Miki Rika, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Niimi Kaoru, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Senga Takeshi, Iwase Akira, Kikkawa Fumitaka, Kotani Tomomi
MOLECULAR MEDICINE REPORTS 19 巻 ( 1 ) 頁： 293-301 2019年1月
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Clinical utility and limitations of FibCare (R) for the rapid measurement of fibrinogen concentrations: The first clinical experience
Imai Kenji, Kotani Tomomi, Nakano Tomoko, Ushida Takafumi, Kikkawa Fumitaka
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY 57 巻 ( 6 ) 頁： 899-900 2018年12月
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A rare pseudo tumour in the extraembryonic coelom in first trimester of pregnancy: ultrasound and pathology.
Sumigama S, Enomoto A, Matsukawa S, Ushida T, Imai K, Nakano T, Kotani T, Kikkawa F
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 頁： 1-2 2018年11月
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The rate of neonatal respiratory distress syndrome/transient tachypnea in the newborn and the amniotic lamellar body count in twin pregnancies compared with singleton pregnancies
Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka
CLINICA CHIMICA ACTA 484 巻 頁： 293-297 2018年9月
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The impact of fertility treatment on the neonatal respiratory outcomes and amniotic lamellar body counts in twin pregnancies
Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka
CLINICA CHIMICA ACTA 484 巻 頁： 192-196 2018年9月
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PLACENTAL PROTEOMIC ANALYSIS OF PLACENTA ACCRETA
Moriyama Yoshinori, Sumigama Seiji, Mizutani Teruyuki, Nomoto Masataka, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka
PLACENTA 69 巻 頁： E74-E75 2018年9月
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PLACENTAL MORPHOLOGY AND PREGNANCY COMPLICATIONS IN FULLTERM PREGNANCY
Ushida Takafumi, Mizutani Teruyuki, Nomoto Masataka, Moriyama Yoshinori, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka
PLACENTA 69 巻 頁： E76-E76 2018年9月
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EFFECTOR REGULATORY. CELLS IN THE DECIDUA DECREASE IN LABOR
Mizutani Teruyuki, Kotani Tomomi, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Moriyama Yoshinori, Nomoto Masataka, Kikkawa Fumitaka
PLACENTA 69 巻 頁： E69-E69 2018年9月
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DRUG REPOSITIONING FOR SEARCH THE DRUG TO SUPPORT PLACENTAL GROWTH
Nomoto Masataka, Kotani Tomomi, Mizutani Teruyuki, Moriyama Yoshinori, Ushida Takefumi, Imai Kenji, Nakano Tomoko, Kikkawa Fumitaka
PLACENTA 69 巻 頁： E21-E21 2018年9月
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Altered proteomic profile in umbilical arterial serum from mothers with schizophrenia
Moriyama Yoshinori, Kotani Tomomi, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Tsuda Hiroyuki, Kikkawa Fumitaka
SCHIZOPHRENIA RESEARCH 197 巻 頁： 615-617 2018年7月
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Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model
Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Ushida Takafumi, Iwase Akira, Nagai Taku, Toyokuni Shinya, Suzumura Akio, Kikkawa Fumitaka
SCIENTIFIC REPORTS 8 巻 ( 1 ) 頁： 9221 2018年6月
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Effect of molecular hydrogen on uterine inflammation during preterm labour
Nakano Tomoko, Kotani Tomomi, Imai Kenji, Iitani Yukako, Ushida Takafumi, Tsuda Hiroyuki, Li Hua, Iwase Akira, Toyokuni Shinya, Kikkawa Fumitaka
BIOMEDICAL REPORTS 8 巻 ( 5 ) 頁： 454-460 2018年5月
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Maternal protein S activity is associated with massive hemorrhage during caesarean section: retrospective case-control study. 査読有り
Imai K, Kotani T, Nakano T, Ushida T, Hirakawa A, Kikkawa F
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 頁： 1-181 2018年2月
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The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis.
Moroi H, Kotani T, Miki R, Tsuda H, Mizuno M, Ito Y, Ushida T, Imai K, Nakano T, Li H, Sumigama S, Yamamoto E, Iwase A, Kikkawa F
Journal of clinical biochemistry and nutrition 62 巻 ( 1 ) 頁： 63-67 2018年1月
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Discordant Relationship Between Evaluation of Facial Expression and Subjective Pain Rating Due to the Low Pain Magnitude.
Hayashi K, Ikemoto T, Ueno T, Arai YP, Shimo K, Nishihara M, Suzuki S, Ushida T
Basic and clinical neuroscience 9 巻 ( 1 ) 頁： 43 - 50 2018年1月
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ABERRANT MATERNAL INFLAMMATION IN PREGNANCY LEADS TO PERSISTENCE OF RISK FACTORS FOR CARDIOVASCULAR DISEASE IN THE OFFSPRING
Ushida Takafumi, Macdonald-Goodfellow Shannyn, Tse M. Yat, Winn Louise, Pang Stephen, Adams Michael, Kotani Tomomi, Kikkawa Fumitaka, Graham Charles
PLACENTA 57 巻 頁： 243-243 2017年9月
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PERSISTENCE OF RISK FACTORS ASSOCIATED WITH MATERNAL CARDIOVASCULAR DISEASE FOLLOWING ABERRANT INFLAMMATION IN RAT PREGNANCY
Ushida Takafumi, Macdonald-Goodfellow Shannyn, Quadri Allegra, Tse M. Yat, Winn Louise, Pang Stephen, Adams Michael, Kotani Tomomi, Kikkawa Fumitaka, Graham Charles
PLACENTA 57 巻 頁： 279-279 2017年9月
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A large mediastinal tumour invading into the liver with foetal hydrops: A rare case of infantile myofibromatosis 査読有り
Ushida Takafumi, Tsuda Hiroyuki, Takahara Taishi, Takahashi Yuichiro, Kotani Tomomi, Kikkawa Fumitaka
JOURNAL OF OBSTETRICS AND GYNAECOLOGY 37 巻 ( 6 ) 頁： 821-823 2017年
科研費 2
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ターゲットプロテオミクス応用による母体胎児境界面環境戦略に向けた学際的研究
研究課題/研究課題番号：23KK0157 2023年9月 - 2027年3月
科学研究費助成事業 国際共同研究加速基金(海外連携研究)
小谷 友美, 牛田 貴文, 伊吉 祥平, 松尾 聖子
担当区分：研究分担者
わが国では約1/13人が生殖補助医療（ART)で誕生する。ART妊娠に多い合併症に、癒着胎盤スペクトラム及び妊娠高血圧腎症がある。いずれも母児間境界面における絨毛細胞（胎児）と間葉系脱落膜細胞（母体）との相互作用による胎盤絨毛浸潤異常(各々過剰・不全)が関与する。母児間境界面を一つの包括的環境基軸と見なし、「胎児-母体間の細胞コミュニケーション」をつなぐ主要な媒体であるペプチドに着目する。 Schilling博士(フライブルグ大学)との国際共同研究を通して、ターゲットプロテオミクス解析を用いて機序を解明し、ペプチダーゼ阻害剤の創薬につなげ、ART妊娠女性への新たな治療開発を目指す。
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妊娠高血圧症候群による児の神経学的後障害の病態解明と先制医療への戦略
研究課題/研究課題番号：22K16857 2022年4月 - 2025年3月
科学研究費助成事業 若手研究
牛田 貴文
担当区分：研究代表者
配分額：4420000円 （ 直接経費：3400000円 、 間接経費：1020000円 ）
妊娠高血圧症候群は妊婦の5～10%に発症し、高血圧や蛋白尿を特徴とする疾患である。妊娠高血圧症候群を発症した母から出生した児は、脳性麻痺や運動障害のみならず自閉症スペクトラム障害、注意欠陥多動性障害などの神経学的後障害のリスクが上昇することが報告されている。本研究では妊娠高血圧症候群による胎内での児の脳神経・免疫細胞への影響を解析する。また、MRI画像を用いた解析や日本の約200施設の早産児データベースを用いた解析により、神経学的後障害のハイリスクとなる児をどのように早期に見つけ出すかという臨床上の課題に取り組む。