Updated on 2025/04/01

写真a

 
USHIDA Takafumi
 
Organization
Nagoya University Hospital Maternity and Perinatal Care Center Associate professor
Graduate School
Graduate School of Medicine
Title
Associate professor

Degree 1

  1. 医学博士 ( 2017.7   名古屋大学 ) 

Research Interests 4

  1. エピジェネティクス

  2. メタボリック症候群

  3. 心血管障害

  4. 妊娠高血圧腎症, 母体炎症

Research Areas 2

  1. Life Science / Obstetrics and gynecology

  2. Life Science / Embryonic medicine and pediatrics

Current Research Project and SDGs 2

  1. 妊娠高血圧腎症妊婦から出生した児におけるDOHaD仮説の検証と早期介入への戦略

  2. 妊娠高血圧腎症と将来の心血管障害発症との関連性~エピジェネティクスの観点より

Research History 3

  1. Nagoya University   Assistant Professor

    2017.4

  2. Nagoya University

    2013.4 - 2017.3

  3. 愛知県厚生農業協同組合連合会 安城更生病院   産婦人科

    2006.4 - 2013.3

Education 1

  1. Nagoya University

    1999.4 - 2006.3

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    Country: Japan

Professional Memberships 4

  1. 日本産科婦人科学会   指導医

  2. 日本周産期・新生児医学会   指導医

  3. 日本妊娠高血圧学会   総務役員

  4. 日本胎盤学会

Committee Memberships 1

  1. 日本妊娠高血圧学会   総務委員  

    2018.4   

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    Committee type:Academic society

Awards 3

  1. 学術集会長賞

    2019.11   日本産科麻酔学会  

  2. 学術奨励賞

    2018.12   尚和会  

  3. Y.W. Loke New Investigator Travel Award

    2014.9   International Federation of Placenta Associations  

 

Papers 105

  1. Visualizing risk modification of hypertensive disorders of pregnancy: development and validation of prediction model for personalized interpregnancy weight management

    Tano, S; Kotani, T; Ushida, T; Matsuo, S; Yoshihara, M; Imai, K; Kinoshita, F; Moriyama, Y; Nomoto, M; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    HYPERTENSION RESEARCH   Vol. 48 ( 3 ) page: 884 - 893   2025.3

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  2. Dietary supplements and prevention of preeclampsia

    Ushida, T; Tano, S; Matsuo, S; Fuma, K; Imai, K; Kajiyama, H; Kotani, T

    HYPERTENSION RESEARCH     2025.2

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  3. Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders

    Fuma, K; Iitani, Y; Imai, K; Ushida, T; Tano, S; Yoshida, K; Yokoi, A; Miki, R; Kidokoro, H; Sato, Y; Hara, Y; Ogi, T; Nomaki, K; Tsuda, M; Komine, O; Yamanaka, K; Kajiyama, H; Kotani, T

    COMMUNICATIONS BIOLOGY   Vol. 8 ( 1 ) page: 75   2025.1

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  4. Effect of Cytokine Concentrations on Long-term Neurological Outcomes in Fetal Pleural Effusion Managed with Thoracoamniotic Shunt.

    Imai K, Tano S, Fuma K, Matsuo S, Ushida T, Kajiyama H, Kotani T

    JMA journal   Vol. 8 ( 1 ) page: 288 - 292   2025.1

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    Language:English  

    DOI: 10.31662/jmaj.2024-0227

    PubMed

  5. Effect of Cytokine Concentrations on Long-term Neurological Outcomes in Fetal Pleural Effusion Managed with Thoracoamniotic Shunt

    Imai, K; Tano, S; Fuma, K; Matsuo, S; Ushida, T; Kajiyama, H; Kotani, T

    JMA JOURNAL   Vol. 8 ( 1 ) page: 288 - 292   2025.1

  6. Early-onset preeclampsia/gestational hypertension may be associated with a low incidence of cerebral palsy at 3 years old in singleton very low-birth-weight infants born at 28-31 weeks of gestation (EOPE-DQ study): a multi-center retrospective cohort study in 2013-2016

    Ohkuchi, A; Suzuki, H; Kanai, A; Fukuda, M; Takeda, Y; Fuseya, C; Nomiyama, M; Ushida, T; Watanabe, K; Kono, Y; Naruse, K; Seki, H; Saito, S

    HYPERTENSION RESEARCH   Vol. 48 ( 1 ) page: 88 - 101   2025.1

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  7. Patient awareness of long-term cardiovascular and metabolic disease risks after hypertensive disorders of pregnancy in Japan

    Ushida, T; Tano, S; Matsuo, S; Fuma, K; Imai, K; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 51 ( 1 ) page: e16183   2025.1

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  8. Effect of Cytokine Concentrations on Long-term Neurological Outcomes in Fetal Pleural Effusion Managed with Thoracoamniotic Shunt

    Imai, K; Tano, S; Fuma, K; Matsuo, S; Ushida, T; Kajiyama, H; Kotani, T

    JMA JOURNAL     2024.12

  9. Assisted reproductive technology and prolonged third stage of labour: a multicentre study in Japan

    Kato, A; Ushida, T; Matsuo, S; Tano, S; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    REPRODUCTIVE BIOMEDICINE ONLINE   Vol. 49 ( 6 ) page: 104382   2024.12

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  10. Impact of antenatal corticosteroids on subcortical volumes in preterm infants at term-equivalent age: A retrospective observational study

    Fuma, K; Ushida, T; Kawaguchi, M; Nosaka, R; Kidokoro, H; Tano, S; Imai, K; Sato, Y; Hayakawa, M; Kajiyama, H; Kotani, T

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 302   page: 7 - 14   2024.11

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  11. Elevated levels of apolipoprotein A4 in umbilical cord serum from the maternal major depressive disorder

    Matsuo, S; Moriyama, Y; Ushida, T; Imai, K; Tano, S; Miki, R; Yoshida, K; Yokoi, A; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 11 ) page: 2038 - 2045   2024.11

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  12. Sleep state-dependent development of resting-state functional connectivity during the preterm period

    Shiraki, A; Kidokoro, H; Watanabe, H; Taga, G; Ushida, T; Narita, H; Mitsumatsu, T; Kumai, S; Suzui, R; Sawamura, F; Ito, Y; Yamamoto, H; Nakata, T; Sato, Y; Hayakawa, M; Takahashi, Y; Natsume, J

    SLEEP   Vol. 47 ( 12 )   2024.10

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  13. Possible Efficacy of Vaginal Progesterone on Asymptomatic Women with a Short Cervix after 24 Weeks of Gestation: A Historical Cohort Study in Japan

    Otsuka, N; Imai, K; Tano, S; Matsuo, S; Ushida, T; Nomoto, M; Iitani, Y; Ishi, M; Kawai, Y; Furui, T; Kajiyama, H; Kotani, T

    JMA JOURNAL   Vol. 7 ( 4 ) page: 582 - 589   2024.10

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  14. Effect of chorioamnionitis on postnatal growth in very preterm infants: a population-based study in Japan

    Ushida, T; Nosaka, R; Nakatochi, M; Kobayashi, Y; Tano, S; Fuma, K; Matsuo, S; Imai, K; Sato, Y; Hayakawa, M; Kajiyama, H; Kotani, T; Neonatal Res Network Japan

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS     2024.10

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  15. Impact of antenatal corticosteroids-to-delivery interval on very preterm neonatal outcomes: a retrospective study in two tertiary centers in Japan

    Fuma, K; Kotani, T; Tsuda, H; Oshiro, M; Tano, S; Ushida, T; Imai, K; Sato, Y; Kajiyama, H

    BMC PREGNANCY AND CHILDBIRTH   Vol. 24 ( 1 ) page: 607   2024.9

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  16. TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta

    Miki, R; Matsuo, S; Ushida, T; Tano, S; Imai, K; Nawa, A; Kajiyama, H; Kotani, T

    MOLECULAR AND CELLULAR ENDOCRINOLOGY   Vol. 591   page: 112277   2024.9

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  17. PATHOPHYSIOLOGY OF INCREASED VASCULAR PERMEABILITY MEDIATED BY PLACENTA-DERIVED EXTRACELLULAR VESICLES IN PREECLAMPSIA.

    Matsuo, S; Yokoi, A; Ushida, T; Yoshida, K; Kitagawa, M; Inami, E; Tano, S; Imai, K; Kajiyama, H; Kotani, T

    PLACENTA   Vol. 154   page: 226 - 226   2024.9

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  18. Identifying the high-benefit population for weight management-based cardiovascular disease prevention in Japan

    Tano, S; Kotani, T; Matsuo, S; Ushida, T; Imai, K; Kajiyama, H

    PREVENTIVE MEDICINE REPORTS   Vol. 43   page: 102782   2024.7

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  19. Amniotic fluid-derived small extracellular vesicles for predicting postnatal severe outcome of congenital diaphragmatic hernia.

    Matsuo S, Yokoi A, Yoshida K, Kitagawa M, Asano-Inami E, Miura M, Yasui T, Tano S, Ushida T, Imai K, Kajiyama H, Kotani T

    Journal of extracellular biology   Vol. 3 ( 6 ) page: e160   2024.6

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    Language:English  

    DOI: 10.1002/jex2.160

    PubMed

  20. Postpartum and interpregnancy care of women with a history of hypertensive disorders of pregnancy

    Ushida, T; Tano, S; Imai, K; Matsuo, S; Kajiyama, H; Kotani, T

    HYPERTENSION RESEARCH   Vol. 47 ( 6 ) page: 1457 - 1469   2024.6

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  21. Predictive performance of Shock Index for postpartum hemorrhage during cesarean delivery

    Mizutani, H; Ushida, T; Ozeki, K; Tano, S; Iitani, Y; Imai, K; Nishiwaki, K; Kajiyama, H; Kotani, T

    INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA   Vol. 58   page: 103957   2024.5

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  22. Intrauterine exposure to chorioamnionitis and neuroanatomical alterations at term-equivalent age in preterm infants

    Nosaka, R; Ushida, T; Kidokoro, H; Kawaguchi, M; Shiraki, A; Iitani, Y; Imai, K; Nakamura, N; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 309 ( 5 ) page: 1909 - 1918   2024.5

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  23. Importance of the time sequence between measurement of the predictor and of the predicted outcome: Response

    Mizutani, H; Ushida, T; Kajiyama, H; Kotani, T

    INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA   Vol. 58   page: 103995   2024.5

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  24. Practical weight management to minimize pregnancy complications and promote women's health: the possibility of interpregnancy care

    Kotani, T; Tano, S; Ushida, T; Imai, K; Kajiyama, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 86 ( 2 ) page: 160 - 168   2024.5

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  25. Predicting preterm birth within 2 weeks in asymptomatic women with a short cervix: Combined effects of cervicovaginal fluid cytokine levels and fetal fibronectin test

    Ohori, Y; Imai, K; Tano, S; Owaki, T; Miki, R; Nozaki, Y; Ushida, T; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 4 ) page: 587 - 595   2024.4

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  26. Interleukin-17A stimulation induces alterations in Microglial microRNA expression profiles

    Iitani, Y; Miki, R; Imai, K; Fuma, K; Ushida, T; Tano, S; Yoshida, K; Yokoi, A; Kajiyama, H; Kotani, T

    PEDIATRIC RESEARCH   Vol. 95 ( 1 ) page: 167 - 173   2024.1

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  27. Risk factors for non-previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan

    Matsuo, S; Kotani, T; Tano, S; Ushida, T; Imai, K; Nakamura, T; Osuka, S; Goto, M; Osawa, M; Asada, Y; Kajiyama, H

    REPRODUCTIVE MEDICINE AND BIOLOGY   Vol. 23 ( 1 ) page: e12592   2024.1

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  28. Sex-specific differences in head circumference of term singletons after assisted reproductive technology: a multicentre study in Japan

    Matsuo, S; Ushida, T; Tano, S; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    REPRODUCTIVE BIOMEDICINE ONLINE   Vol. 47 ( 6 ) page: 103331   2023.12

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  29. New-onset postpartum hypertension in women without a history of hypertensive disorders of pregnancy: a multicenter study in Japan

    Ushida, T; Nakamura, N; Katsuki, S; Mizutani, H; Iitani, Y; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    HYPERTENSION RESEARCH   Vol. 46 ( 12 ) page: 2583 - 2592   2023.12

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  30. Antenatal prediction models for outcomes of extremely and very preterm infants based on machine learning

    Ushida, T; Kotani, T; Baba, J; Imai, K; Moriyama, Y; Nakano-Kobayashi, T; Iitani, Y; Nakamura, N; Hayakawa, M; Kajiyama, H

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 308 ( 6 ) page: 1755 - 1763   2023.12

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  31. Antenatal corticosteroids and outcomes of small for gestational age infants born at 24-31 gestational weeks: a population-based propensity score matching analysis

    Ushida, T; Nakatochi, M; Kobayashi, Y; Nakamura, N; Fuma, K; Iitani, Y; Imai, K; Sato, Y; Hayakawa, M; Kajiyama, H; Kotani, T; Japan, NRNO

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 308 ( 5 ) page: 1463 - 1471   2023.11

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  32. Comparison of the efficacy between controlled-release dinoprostone delivery system (PROPESS) and Cook's double balloon catheter plus oxytocin: A retrospective single-center study in Japan

    Imai, K; Nozaki, Y; Ushida, T; Tano, S; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 9 ) page: 2317 - 2323   2023.9

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  33. Altered offspring neurodevelopment in an L-NAME-induced preeclampsia rat model

    Nakamura, N; Ushida, T; Onoda, A; Ueda, K; Miura, R; Suzuki, T; Katsuki, S; Mizutani, H; Yoshida, K; Tano, S; Iitani, Y; Imai, K; Hayakawa, M; Kajiyama, H; Sato, Y; Kotani, T

    FRONTIERS IN PEDIATRICS   Vol. 11   page: 1168173   2023.7

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  34. Evaluating glucose variability through OGTT in early pregnancy and its association with hypertensive disorders of pregnancy in non-diabetic pregnancies: a large-scale multi-center retrospective study

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakamura, N; Iitani, Y; Moriyama, Y; Emoto, R; Kato, S; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Matsui, S; Kajiyama, H

    DIABETOLOGY & METABOLIC SYNDROME   Vol. 15 ( 1 ) page: 123   2023.6

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  35. Antenatal corticosteroids-to-delivery interval associates cord blood S100B levels

    Fuma, K; Kotani, T; Ushida, T; Imai, K; Iitani, Y; Nakamura, N; Miki, R; Katsuki, S; Kinoshita, F; Sato, Y; Hayakawa, M; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 4 ) page: 1129 - 1136   2023.4

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  36. Clinical significances of Bishop score and vaginal bleeding to controlled-release dinoprostone delivery system (PROPESS) efficacy for cervical ripening: A retrospective single-center study in Japan

    Imai, K; Aoki, C; Tano, S; Iitani, Y; Nakamura, N; Ushida, T; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 4 ) page: 1154 - 1160   2023.4

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  37. Trend changes in age-related body mass index gain after coronavirus disease 2019 pandemic in Japan: a multicenter retrospective cohort study

    Tano, S; Kotani, T; Ushida, T; Iitani, Y; Imai, K; Kinoshita, F; Kajiyama, H

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 21 ( 1 ) page: 7   2023.1

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  38. Prenatal diagnosis of distal 13q deletion syndrome in a fetus with esophageal atresia: a case report and review of the literature

    Kotani, T; Tsuda, H; Ito, Y; Nakamura, N; Ushida, T; Imai, K; Iitani, Y; Fuma, K; Muramatsu, Y; Hayakawa, M; Kajiyama, H

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 16 ( 1 ) page: 481   2022.12

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  39. A case of non-immune hydrops fetalis with maternal mirror syndrome diagnosed by trio-based exome sequencing: An autopsy case report and literature review

    Tano, S; Kotani, T; Yoshihara, M; Nakamura, N; Matsuo, S; Ushida, T; Imai, K; Ito, M; Oka, Y; Sato, E; Hayashi, S; Ogi, T; Kajiyama, H

    MOLECULAR GENETICS AND METABOLISM REPORTS   Vol. 33   page: 100925   2022.12

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  40. Aberrant inflammation in rat pregnancy leads to cardiometabolic alterations in their offspring and intrauterine growth restriction in the F2 generation

    Ushida, T; Cotechini, T; Protopapas, N; Atallah, A; Collyer, C; Toews, AJ; Macdonald-Goodfellow, SK; Tse, MY; Winn, LM; Pang, SC; Adams, MA; Othman, M; Kotani, T; Kajiyama, H; Graham, CH

    JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE   Vol. 13 ( 6 ) page: 706 - 718   2022.12

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  41. Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells

    Aoki, C; Imai, K; Mizutani, T; Sugiyama, D; Miki, R; Koya, Y; Kobayashi, T; Ushida, T; Iitani, Y; Nakamura, N; Owaki, T; Nishikawa, H; Toyokuni, S; Kajiyama, H; Kotani, T

    LIFE SCIENCES   Vol. 308   page: 120955   2022.11

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  42. 5p deletion with congenital diaphragmatic hernia: a case report

    Kotani, T; Ushida, T; Nakamura, N; Imai, K; Iitani, Y; Tano, S; Iwagaki, S; Takahashi, Y; Ito, M; Hayakawa, M; Kajiyama, H

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 16 ( 1 ) page: 390   2022.10

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  43. Optimal annual body mass index change for preventing spontaneous preterm birth in a subsequent pregnancy

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Iitani, Y; Kinoshita, F; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 17502   2022.10

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  44. DEVELOPING OF A NOVEL THERAPEUTIC AGENT FOR FGR THROUGH DRUG REPOSITIONING

    Tano, S; Kotani, T; Ushida, T; Nakamura, N; Iitani, Y; Yoshihara, M; Imai, K; Kajiyama, H

    PLACENTA   Vol. 128   page: 124 - 124   2022.10

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  45. Severe Congenital Diaphragmatic Hernia With Trisomy 9: A Case Report and Review of the Literature

    Fuma, K; Kotani, T; Nakamura, N; Ushida, T; Kajiyama, H

    CUREUS JOURNAL OF MEDICAL SCIENCE   Vol. 14 ( 8 ) page: e28395   2022.8

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  46. Impact of hypertensive disorders of pregnancy on respiratory outcomes in extremely and very preterm infants: A population-based study in Japan

    Ushida, T; Nakamura, N; Nakatochi, M; Kobayashi, Y; Sato, Y; Iitani, Y; Imai, K; Nakano-Kobayashi, T; Hayakawa, M; Kajiyama, H; Kotani, T

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 29   page: 54 - 60   2022.8

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  47. Machine learning prediction models for postpartum depression: A multicenter study in Japan

    Matsuo, S; Ushida, T; Emoto, R; Moriyama, Y; Iitani, Y; Nakamura, N; Imai, K; Nakano-Kobayashi, T; Yoshida, S; Yamashita, M; Matsui, S; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 7 ) page: 1775 - 1785   2022.7

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  48. Reassessing the duration of each stage of labor and their relation to postpartum hemorrhage in the current Japanese population

    Ushida, T; Matsuo, S; Nakamura, N; Iitani, Y; Imai, K; Nakano-Kobayashi, T; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 7 ) page: 1760 - 1767   2022.7

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  49. The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia

    Aoki, C; Imai, K; Owaki, T; Kobayashi-Nakano, T; Ushida, T; Iitani, Y; Nakamura, N; Kajiyama, H; Kotani, T

    MEDICINA-LITHUANIA   Vol. 58 ( 6 )   2022.6

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  50. Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb)

    Maki, S; Tanaka, H; Takakura, S; Nii, M; Tanaka, K; Ogura, T; Kotera, M; Nishimura, Y; Tamaru, S; Ushida, T; Tanaka, Y; Kikuchi, N; Kinjo, T; Kawamura, H; Takano, M; Nakamura, K; Suga, S; Kasai, M; Yasui, O; Nagao, K; Maegawa, Y; Kotani, T; Endo, M; Yasuhi, I; Aoki, S; Aoki, Y; Yoshida, Y; Nakata, M; Sekizawa, A; Ikeda, T

    BMJ OPEN   Vol. 12 ( 6 ) page: e054925   2022.6

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  51. Intrauterine exposure to hypertensive disorders of pregnancy and postnatal growth in extremely and very preterm infants

    Ushida, T; Kotani, T; Nakatochi, M; Kobayashi, Y; Nakamura, N; Imai, K; Iitani, Y; Nakano-Kobayashi, T; Hayakawa, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 28   page: 174 - 179   2022.6

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  52. Pregnancy Outcomes in Women with Thyroid Diseases

    Kotani, T; Imai, K; Ushida, T; Moriyama, Y; Nakano-Kobayashi, T; Osuka, S; Tsuda, H; Sumigama, S; Yamamoto, E; Kinoshita, F; Hirakawa, A; Iwase, A; Kikkawa, F; Kajiyama, H

    JMA JOURNAL   Vol. 5 ( 2 ) page: 216 - 223   2022.4

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  53. Assessment of placental abruption with diffusion-weighted imaging

    Mizutani, T; Kotani, T; Kato, N; Imai, K; Ushida, T; Nakano-Kobayashi, T; Kinoshita, Y; Ito, M; Kinoshita, F; Yamamuro, O; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 4 ) page: 930 - 937   2022.4

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  54. Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase

    Koike Hiroshi, Nishida Yoshihiro, Shinomura Tamayuki, Ohkawara Bisei, Ohno Kinji, Zhuo Lisheng, Kimata Koji, Ushida Takahiro, Imagama Shiro

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 23 ( 8 )   2022.4

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  55. Annual Body Mass Index Gain and Risk of Gestational Diabetes Mellitus in a Subsequent Pregnancy

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Iitani, Y; Kinoshita, F; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    FRONTIERS IN ENDOCRINOLOGY   Vol. 13   page: 815390   2022.3

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  56. Pre-pregnancy sleep duration and postpartum depression: a multicenter study in Japan

    Matsuo, S; Ushida, T; Iitani, Y; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    ARCHIVES OF WOMENS MENTAL HEALTH   Vol. 25 ( 1 ) page: 181 - 189   2022.2

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  57. Liver transaminase levels during pregnancy: a Japanese multicenter study Reviewed

    Ushida, T; Kotani, T; Kinoshita, F; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE   Vol. 35 ( 25 ) page: 5761 - 5767   2022

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  58. Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study

    Katsuki, S; Ushida, T; Kidokoro, H; Nakamura, N; Iitani, Y; Fuma, K; Imai, K; Nakano-Kobayashi, T; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    EARLY HUMAN DEVELOPMENT   Vol. 163   page: 105479   2021.12

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  59. Prevalence and risk factors of labor-onset hypertension: A multicenter study in Japan

    Ushida, T; Kotani, T; Imai, K; Nakano-Kobayashi, T; Iitani, Y; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 26   page: 48 - 53   2021.12

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  60. Annual body mass index gain and risk of hypertensive disorders of pregnancy in a subsequent pregnancy

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Iitani, Y; Kinoshita, F; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 22519   2021.11

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  61. Manual removal of the placenta and postpartum hemorrhage: A multicenter retrospective study

    Fujita, K; Ushida, T; Imai, K; Nakano-Kobayashi, T; Iitani, Y; Matsuo, S; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 11 ) page: 3867 - 3874   2021.11

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  62. Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction

    Nomoto, M; Kotani, T; Miki, R; Ushida, T; Imai, K; Iitani, Y; Tano, S; Wang, JW; Moriyama, Y; Kobayashi, T; Mimura, N; Iriyama, T; Kikkawa, F; Kajiyama, H

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 69 ( 3 ) page: 280 - 285   2021.11

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  63. TRANSGENERATIONAL EFFECTS OF ABERRANT INFLAMMATION IN RAT PREGNANCY

    Atallah, A; Ushida, T; Protopapas, N; Macdonald-Goodfellow, S; Graham, C; Cotechini, T

    PLACENTA   Vol. 112   page: E39 - E39   2021.9

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  64. Current Issues within the Perinatal Mental Health Care System in Aichi Prefecture, Japan: A Cross-Sectional Questionnaire Survey

    Fujita, K; Kotani, T; Moriyama, Y; Ushida, T; Imai, K; Kobayashi-Nakano, T; Kato, N; Kano, T; Kikkawa, F; Kajiyama, H

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH   Vol. 18 ( 17 )   2021.9

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  65. Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia

    Miura, M; Imai, K; Tsuda, H; Miki, R; Tano, S; Ito, Y; Hirako-Takamura, S; Moriyama, Y; Ushida, T; Iitani, Y; Nakano-Kobayashi, T; Toyokuni, S; Kajiyama, H; Kotani, T

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 22 ( 17 )   2021.9

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  66. Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study

    Ushida, T; Kidokoro, H; Nakamura, N; Katsuki, S; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 25   page: 143 - 149   2021.8

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  67. Antenatal prediction models for short- and medium-term outcomes in preterm infants

    Ushida, T; Moriyama, Y; Nakatochi, M; Kobayashi, Y; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Hayakawa, M; Kajiyama, H; Kotani, T

    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA   Vol. 100 ( 6 ) page: 1089 - 1096   2021.6

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  68. Platelet counts during normal pregnancies and pregnancies complicated with hypertensive disorders

    Ushida, T; Kotani, T; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Kinoshita, F; Nakamura, N; Iitani, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 24   page: 73 - 78   2021.6

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  69. Assessment of myocardial performance index in late-onset fetal growth restriction

    Nguyen, TTN; Kotani, T; Imai, K; Ushida, T; Moriyama, Y; Kobayashi, T; Niimi, K; Sumigama, S; Yamamoto, E; Vo, VD; Le, MT; Le, LH; Nguyen, DN; Nguyen, VQH; Truong, QV; Cao, NT; Kikkawa, F

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 2 ) page: 259 - 268   2021.5

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  70. Postpartum alterations following inflammation in rat pregnancy: a discovery proteomic analysis

    Ushida, T; Kotani, T; Moriyama, Y; Hindmarch, CCT; Cotechini, T; Imai, K; Nakano-Kobayashi, T; Kajiyama, H; Graham, CH

    REPRODUCTION   Vol. 161 ( 5 ) page: 513 - 522   2021.5

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  71. Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia Reviewed

    Ito, Y; Tsuda, H; Imai, K; Miki, R; Miura, M; Tachi, A; Tano, S; Hirako-Takamura, S; Moriyama, Y; Ushida, T; Kobayashi, T; Sumigama, S; Kajiyama, H; Kikkawa, F; Kotani, T

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 700   page: 108769   2021.3

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  72. Trisomy 5p with bilateral congenital diaphragmatic hernia: a case report

    Nakamura, N; Ushida, T; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Osuka, S; Goto, M; Kajiyama, H; Asada, H; Hayakawa, M; Kotani, T

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 15 ( 1 ) page: 114   2021.3

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  73. Maternal low birth weight and hypertensive disorders of pregnancy

    Ushida, T; Kotani, T; Kinoshita, F; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 23   page: 5 - 10   2021.3

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  74. Shock Index and Postpartum Hemorrhage in Vaginal Deliveries: A Multicenter Retrospective Study

    Ushida, T; Kotani, T; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H; Kikkawa, F

    SHOCK   Vol. 55 ( 3 ) page: 332 - 337   2021.3

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  75. Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage Reviewed

    Owaki, T; Imai, K; Miki, R; Niwa, Y; Kotani, T; Nakano-Kobayashi, T; Ushida, T; Kajiyama, H

    CYTOKINE   Vol. 138   page: 155406   2021.2

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  76. Mortality and neurological outcomes in extremely and very preterm infants born to mothers with hypertensive disorders of pregnancy Reviewed

    Nakamura, N; Ushida, T; Nakatochi, M; Kobayashi, Y; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Hayakawa, M; Kajiyama, H; Kikkawa, F; Kotani, T

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 1729   2021.1

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  77. Forced expression of KIAA1199, a novel hyaluronidase, inhibits tumorigenicity of low-grade chondrosarcoma

    Koike Hiroshi, Nishida Yoshihiro, Shinomura Tamayuki, Zhuo Lisheng, Hamada Shunsuke, Ikuta Kunihiro, Ito Kan, Kimata Koji, Ushida Takahiro, Ishiguro Naoki

    JOURNAL OF ORTHOPAEDIC RESEARCH   Vol. 38 ( 9 ) page: 1942 - 1951   2020.9

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  78. Antenatal corticosteroids and preterm offspring outcomes in hypertensive disorders of pregnancy: A Japanese cohort study Reviewed

    Ushida, T; Kotani, T; Hayakawa, M; Hirakawa, A; Sadachi, R; Nakamura, N; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Kikkawa, F

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 9312   2020.6

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  79. Antenatal Corticosteroids and Outcomes in Preterm Twins Reviewed

    Ushida, T; Kotani, T; Sadachi, R; Hirakawa, A; Hayakawa, M; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Kikkawa, F

    OBSTETRICS AND GYNECOLOGY   Vol. 135 ( 6 ) page: 1387 - 1397   2020.6

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  80. A proteome signature of umbilical cord serum associated with congenital diaphragmatic hernia.

    Tachi A, Moriyama Y, Tsuda H, Miki R, Ushida T, Miura M, Ito Y, Imai K, Nakano-Kobayashi T, Hayakawa M, Kikkawa F, Kotani T

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 345 - 354   2020.5

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    DOI: 10.18999/nagjms.82.2.345

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  81. Determination of the cytokine levels in fetal pleural effusion and their association with fetal/neonatal findings

    Imai, K; Kotani, T; Tsuda, H; Kobayashi, T; Ushida, T; Moriyama, Y; Kikkawa, F

    CYTOKINE   Vol. 127   page: 154945   2020.3

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  82. Adverse effects of endometriosis on pregnancy: a case-control study Reviewed

    Miura, M; Ushida, T; Imai, K; Wang, JW; Moriyama, Y; Nakano-Kobayashi, T; Osuka, S; Kikkawa, F; Kotani, T

    BMC PREGNANCY AND CHILDBIRTH   Vol. 19 ( 1 ) page: 373   2019.10

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  83. A pitfall in diagnosing fetal abdominal lymphangioma: A report of two cases Reviewed

    Niwa, Y; Imai, K; Kotani, T; Nakano, T; Ushida, T; Moriyama, Y; Kikkawa, F

    JOURNAL OF CLINICAL ULTRASOUND   Vol. 47 ( 8 ) page: 494 - 496   2019.10

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  84. Feasibility of using a handheld tissue hardness meter to quantify uterine contractions and its clinical application for obstetric bleeding management Reviewed

    Imai, K; Kotani, T; Ushida, T; Moriyama, Y; Nakano, T; Kikkawa, F

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 39 ( 6 ) page: 757 - 762   2019.8

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  85. Maternal protein S activity is associated with massive hemorrhage during caesarean section: retrospective case-control study. Reviewed

    Imai K, Kotani T, Nakano T, Ushida T, Hirakawa A, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 32 ( 16 ) page: 2633 - 2637   2019.8

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    DOI: 10.1080/14767058.2018.1443067

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  86. ABERRANT INFLAMMATION IN RAT PREGNANCY CONTRIBUTES TO RISK FACTORS ASSOCIATED WITH CARDIOVASCULAR DISEASE AND PREGNANCY COMPLICATIONS IN SUBSEQUENT GENERATIONS

    Protopapas, N; Ushida, T; Macdonald-Goodfellow, SK; Graham, CH

    PLACENTA   Vol. 83   page: E76 - E76   2019.8

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  87. Relationship between cytokine profiles of cord blood and cord S100B levels in preterm infants.

    Niwa Y, Imai K, Kotani T, Miki R, Nakano T, Ushida T, Moriyama Y, Kikkawa F

    Early human development   Vol. 129   page: 65 - 70   2019.2

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    DOI: 10.1016/j.earlhumdev.2019.01.013

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  88. The role of E2F8 in the human placenta

    Mizuno Masako, Miki Rika, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Niimi Kaoru, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Senga Takeshi, Iwase Akira, Kikkawa Fumitaka, Kotani Tomomi

    MOLECULAR MEDICINE REPORTS   Vol. 19 ( 1 ) page: 293 - 301   2019.1

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    DOI: 10.3892/mmr.2018.9617

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  89. A rare pseudo tumour in the extraembryonic coelom in first trimester of pregnancy: ultrasound and pathology.

    Sumigama S, Enomoto A, Matsukawa S, Ushida T, Imai K, Nakano T, Kotani T, Kikkawa F

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology   Vol. 39 ( 4 ) page: 545 - 546   2019

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    DOI: 10.1080/01443615.2018.1511971

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  90. Clinical utility and limitations of FibCare (R) for the rapid measurement of fibrinogen concentrations: The first clinical experience

    Imai Kenji, Kotani Tomomi, Nakano Tomoko, Ushida Takafumi, Kikkawa Fumitaka

    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY   Vol. 57 ( 6 ) page: 899 - 900   2018.12

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    DOI: 10.1016/j.tjog.2018.10.024

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  91. DRUG REPOSITIONING FOR SEARCH THE DRUG TO SUPPORT PLACENTAL GROWTH

    Nomoto Masataka, Kotani Tomomi, Mizutani Teruyuki, Moriyama Yoshinori, Ushida Takefumi, Imai Kenji, Nakano Tomoko, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E21 - E21   2018.9

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  92. The rate of neonatal respiratory distress syndrome/transient tachypnea in the newborn and the amniotic lamellar body count in twin pregnancies compared with singleton pregnancies

    Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 484   page: 293 - 297   2018.9

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    DOI: 10.1016/j.cca.2018.06.015

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  93. The impact of fertility treatment on the neonatal respiratory outcomes and amniotic lamellar body counts in twin pregnancies

    Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 484   page: 192 - 196   2018.9

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    DOI: 10.1016/j.cca.2018.05.060

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  94. PLACENTAL PROTEOMIC ANALYSIS OF PLACENTA ACCRETA

    Moriyama Yoshinori, Sumigama Seiji, Mizutani Teruyuki, Nomoto Masataka, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E74 - E75   2018.9

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  95. PLACENTAL MORPHOLOGY AND PREGNANCY COMPLICATIONS IN FULLTERM PREGNANCY

    Ushida Takafumi, Mizutani Teruyuki, Nomoto Masataka, Moriyama Yoshinori, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E76 - E76   2018.9

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  96. EFFECTOR REGULATORY. CELLS IN THE DECIDUA DECREASE IN LABOR

    Mizutani Teruyuki, Kotani Tomomi, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Moriyama Yoshinori, Nomoto Masataka, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E69 - E69   2018.9

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  97. Altered proteomic profile in umbilical arterial serum from mothers with schizophrenia

    Moriyama Yoshinori, Kotani Tomomi, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Tsuda Hiroyuki, Kikkawa Fumitaka

    SCHIZOPHRENIA RESEARCH   Vol. 197   page: 615 - 617   2018.7

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    DOI: 10.1016/j.schres.2018.02.024

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  98. Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model

    Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Ushida Takafumi, Iwase Akira, Nagai Taku, Toyokuni Shinya, Suzumura Akio, Kikkawa Fumitaka

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 9221   2018.6

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    DOI: 10.1038/s41598-018-27626-4

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  99. Effect of molecular hydrogen on uterine inflammation during preterm labour

    Nakano Tomoko, Kotani Tomomi, Imai Kenji, Iitani Yukako, Ushida Takafumi, Tsuda Hiroyuki, Li Hua, Iwase Akira, Toyokuni Shinya, Kikkawa Fumitaka

    BIOMEDICAL REPORTS   Vol. 8 ( 5 ) page: 454 - 460   2018.5

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    DOI: 10.3892/br.2018.1082

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  100. The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis.

    Moroi H, Kotani T, Miki R, Tsuda H, Mizuno M, Ito Y, Ushida T, Imai K, Nakano T, Li H, Sumigama S, Yamamoto E, Iwase A, Kikkawa F

    Journal of clinical biochemistry and nutrition   Vol. 62 ( 1 ) page: 63 - 67   2018.1

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    DOI: 10.3164/jcbn.16-103

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  101. Discordant Relationship Between Evaluation of Facial Expression and Subjective Pain Rating Due to the Low Pain Magnitude.

    Hayashi K, Ikemoto T, Ueno T, Arai YP, Shimo K, Nishihara M, Suzuki S, Ushida T

    Basic and clinical neuroscience   Vol. 9 ( 1 ) page: 43 - 50   2018.1

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    DOI: 10.29252/NIRP.BCN.9.1.43

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  102. ABERRANT MATERNAL INFLAMMATION IN PREGNANCY LEADS TO PERSISTENCE OF RISK FACTORS FOR CARDIOVASCULAR DISEASE IN THE OFFSPRING

    Ushida Takafumi, Macdonald-Goodfellow Shannyn, Tse M. Yat, Winn Louise, Pang Stephen, Adams Michael, Kotani Tomomi, Kikkawa Fumitaka, Graham Charles

    PLACENTA   Vol. 57   page: 243 - 243   2017.9

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    DOI: 10.1016/j.placenta.2017.07.074

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  103. PERSISTENCE OF RISK FACTORS ASSOCIATED WITH MATERNAL CARDIOVASCULAR DISEASE FOLLOWING ABERRANT INFLAMMATION IN RAT PREGNANCY

    Ushida Takafumi, Macdonald-Goodfellow Shannyn, Quadri Allegra, Tse M. Yat, Winn Louise, Pang Stephen, Adams Michael, Kotani Tomomi, Kikkawa Fumitaka, Graham Charles

    PLACENTA   Vol. 57   page: 279 - 279   2017.9

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    DOI: 10.1016/j.placenta.2017.07.180

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  104. Persistence of risk factors associated with maternal cardiovascular disease following aberrant inflammation in rat pregnancy Reviewed International coauthorship

    Ushida Takafumi, Macdonald-Goodfellow Shannyn K., Quadri Allegra, Tse M. Yat, Winn Louise M., Pang Stephen C., Adams Michael A., Kotani Tomomi, Kikkawa Fumitaka, Graham Charles H.

    BIOLOGY OF REPRODUCTION   Vol. 97 ( 1 ) page: 143 - 152   2017.7

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    DOI: 10.1093/biolre/iox072

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  105. A large mediastinal tumour invading into the liver with foetal hydrops: A rare case of infantile myofibromatosis Reviewed

    Ushida Takafumi, Tsuda Hiroyuki, Takahara Taishi, Takahashi Yuichiro, Kotani Tomomi, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 37 ( 6 ) page: 821 - 823   2017

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    DOI: 10.1080/01443615.2017.1303468

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KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. Interdisciplinary research toward the feto-maternal interface environmental strategies with targeted proteomics

    Grant number:23KK0157  2023.9 - 2027.3

    Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (International Collaborative Research)

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    Authorship:Coinvestigator(s) 

  2. 妊娠高血圧症候群による児の神経学的後障害の病態解明と先制医療への戦略

    Grant number:22K16857  2022.4 - 2025.3

    科学研究費助成事業  若手研究

    牛田 貴文

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    妊娠高血圧症候群は妊婦の5~10%に発症し、高血圧や蛋白尿を特徴とする疾患である。妊娠高血圧症候群を発症した母から出生した児は、脳性麻痺や運動障害のみならず自閉症スペクトラム障害、注意欠陥多動性障害などの神経学的後障害のリスクが上昇することが報告されている。本研究では妊娠高血圧症候群による胎内での児の脳神経・免疫細胞への影響を解析する。また、MRI画像を用いた解析や日本の約200施設の早産児データベースを用いた解析により、神経学的後障害のハイリスクとなる児をどのように早期に見つけ出すかという臨床上の課題に取り組む。
    本研究では以下の3点を目指している。
    (1)妊娠高血圧症候群を発症した母から生まれた児における神経学的後障害のメカニズム解明、(2)新生児合併症予測プログラムに基づく、Webツールの作成および公開、(3)新生児先進的頭部MRI画像解析を用いた神経学的ハイリスク児抽出アルゴリズムの開発を目指している。
    (1)については、妊娠高血圧症候群モデル動物を用いて神経学的後障害の解析を行うため、sFlt-1アデノ随伴ウィルスベクター投与による動物モデルの作成を行っているが、モデル作成には至らないため、アンギオテンシンII投与による動物モデルを使うことにした。
    (2)については、新生児臨床研究ネットワークのデータベースを用いて、児の神経学的予後(短期および長期)を予測するプログラムを作成したが、より日常臨床で使用しやすいようにWebツールを2023年2月名古屋大学産婦人科学教室のHP上に公開した(https://www.med.nagoya-u.ac.jp/obgy/research/obstetrics/prediction_index.html)。今後は各周産期施設においてこのプログラムの周知、普及を目指す。
    (3)に関しては、妊娠高血圧症候群や絨毛膜羊膜炎などの妊娠合併症が児の脳神経系にどのような変化を生じるか画像解析を用いて知見を集積している。組織学的絨毛膜羊膜炎による児の脳皮質下灰白質における各領域での容積変化を、セグメンテーションツールであるInfant FreeSurferを用いて解析し、両側淡蒼球および側坐核が有意に減少することが明らかになった。今年度は国際誌に投稿しアクセプトされた。また妊娠高血圧症候群による児の脳容積への影響に関する学会発表を行い、今後国際誌に投稿予定である。
    理由
    (1)妊娠高血圧症候群を発症した母から生まれた児における神経学的後障害のメカニズム解明については、sFlt-1アデノ随伴ウィルスベクター投与による動物モデルの作成を行っているが、モデル作成に難渋している。ベクター作成は完了したが、マウスに投与しても十分な血中濃度を得られず、投与量の調整やベクターの変更を行っているが血圧上昇を認めなかった。そのためアンギオテンシンII投与モデルを作成することにした。
    (2)新生児合併症予測プログラムに基づく、Webツールの作成および公開については、2023年2月名古屋大学産婦人科学教室のHP上に公開できた。
    (3)新生児先進的頭部MRI画像解析を用いた神経学的ハイリスク児抽出アルゴリズムの開発については、組織学的絨毛膜羊膜炎による児の脳皮質下灰白質にお
    ける脳容積変化に関する知見を得られ、国際誌にアクセプトされた。上記状況により、進行具合としてはおおむね順調と考える。
    (1)妊娠高血圧症候群を発症した母から生まれた児における神経学的後障害のメカニズム解明については、sFlt-1ウィルスベクターによるモデルは困難と判断し、アンギオテンシンII投与による妊娠高血圧症候群モデルマウスを作成し、神経学的後障害を評価する。
    (2)新生児合併症予測プログラムに基づくWebツールについては、2023年2月に公開が完了したため、今後は各周産期施設においてこのプログラムの周知、普及を目指す。
    (3)新生児先進的頭部MRI画像解析を用いた神経学的ハイリスク児抽出アルゴリズムの開発については、現在Infant FreeSurferを用いて妊娠高血圧症候群による児の脳容積への影響について検討を行う。

  3. Verification of DOHaD theory in the offspring born to mother with preeclampsia, and establishment of early intervention for long term consequences due to preeclampsia.

    Grant number:19K18637  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Ushida Takafumi

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    Authorship:Principal investigator 

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    Growing evidence demonstrated that offspring born from mothers with hypertensive disorders of pregnancy (HDP) have increased risk for various complications such as cardiovascular disease, diabetes mellitus, and neurodevelopmental disorders. In this study, we demonstrated that abnormal maternal inflammation can contribute to increased risk of cardiovascular disease and metabolic disease in the offspring, and that the effects of inflammation may cross generations.
    In addition, we evaluated the alterations of brain volume, brain injury score, and metabolism attributed to intrauterine exposure to HDP in very preterm infants. Our study contributed to the elucidation of mechanism of neurodevelopmental disorders.

  4. Preeclampsia on subsequent risk of cardiovascular and metabolic disease in mothers

    Grant number:17H06754  2017.8 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Research Activity Start-up

    Ushida Takafumi

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    Authorship:Principal investigator 

    Grant amount:\2730000 ( Direct Cost: \2100000 、 Indirect Cost:\630000 )

    Preeclampsia is one of the pregnancy complications characterized by new-onset hypertension and proteinuria. Recent epidemiological researches have revealed that women experienced preeclampsia have 2-4 times increased risk of cardiovascular disease and metabolic disease in later life. We sought to demonstrate that the increased risks are due to maternal aberrant inflammation by using animal model. We found that abnormal inflammation during pregnancy developed preeclampsia and affected the risks of subsequent cardiovascular and metabolic diseases in mothers. Thus, these results suggested that anti-inflammatory agents such as TNF-α might decrease these risks.