Updated on 2022/04/07

写真a

 
KONDO Yutaka
 
Organization
Graduate School of Medicine Center for Neurological Diseases and Cance Division Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor

Degree 1

  1. 医学博士 ( 2000.3   名古屋市立大学 ) 

Research Interests 4

  1. 疾患研究

  2. 腫瘍生物学

  3. 非翻訳RNA

  4. エピジェネティクス

Research Areas 1

  1. Life Science / Tumor biology

Current Research Project and SDGs 1

  1. がんエピゲノムの解明

Education 2

  1. Nagoya City University   Graduate School, Division of Medicine

    1996.4 - 2000.3

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    Country: Japan

  2. Nagoya City University   Faculty of Medicine

    1984.4 - 1990.3

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    Country: Japan

 

Papers 23

  1. Newly established patient-derived organoid model of intracranial meningioma.

    Yamazaki S, Ohka F, Hirano M, Shiraki Y, Motomura K, Tanahashi K, Tsujiuchi T, Motomura A, Aoki K, Shinjo K, Murofushi Y, Kitano Y, Maeda S, Kato A, Shimizu H, Yamaguchi J, Adilijiang A, Wakabayashi T, Saito R, Enomoto A, Kondo Y, Natsume A

    Neuro-oncology   Vol. 23 ( 11 ) page: 1936 - 1948   2021.11

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    Language:English  

    DOI: 10.1093/neuonc/noab155

    PubMed

  2. Cancer-specific targeting of taurine upregulated gene 1 enhances the effects of chemotherapy in pancreatic cancer Invited Reviewed

    Tasaki T, Suzuki M, Katsushima K, Shinjo K, Iijima K, Murofushi Y, Naiki-Ito A, Hayashi K, Qiu C, Takahashi A, Tanaka Y, Kawaguchi T, Sugawara M, Kataoka T, Taito M, Miyata K, Kataoka K, Noda T, Gao W, Kataoka H, Takahashi S, Kimura K, Kondo Y

      Vol. 81 ( 7 ) page: 1654 - 1666   2021.4

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    Language:English  

    DOI: 10.1158/0008-5472.CAN-20-3021

    PubMed

  3. Peritoneal Lavage Tumor DNA as a Novel Biomarker for Predicting Peritoneal Recurrence in Pancreatic Ductal Adenocarcinoma.

    Suenaga M, Fujii T, Yamada S, Hayashi M, Shinjo K, Takami H, Niwa Y, Sonohara F, Shimizu D, Kanda M, Kobayashi D, Tanaka C, Nakayama G, Koike M, Fujiwara M, Kondo Y, Kodera Y

    Annals of surgical oncology   Vol. 28 ( 4 ) page: 2277 - 2286   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-020-08990-w

    Web of Science

    PubMed

  4. Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder Invited Reviewed

    Kato H, Kushima I, Mori D, Yoshimi A, Branko A, Nawa Y, Toyama M, Furuta S, Yanjie Yu, Ishizuka K, Kimura H, Arioka Y, Tsujimura K, Morikawa M, Okada T, Inada T, Nakatochi M, Shinjo K, Kondo Y, Kaibuchi K, Funabiki Y, Kimura R, Suzuki T, Yamakawa K, Ikeda M, Iwata N, Takahashi T, Suzuki M, Okahisa Y, Takaki M, Egawa J, Someya T, Ozaki N

    Transl Psychiatry   Vol. 10 ( 1 ) page: 421 - 421   2020.12

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    Language:English  

    DOI: 10.1038/s41398-020-01107-7

    PubMed

  5. Long non-coding RNA: A recently accentuated molecule in chemoresistance in cancer.

    Peng Y, Tang D, Zhao M, Kajiyama H, Kikkawa F, Kondo Y

    Cancer metastasis reviews   Vol. 39 ( 3 ) page: 825 - 835   2020.9

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  6. The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells.

    Hirata E, Ishibashi K, Kohsaka S, Shinjo K, Kojima S, Kondo Y, Mano H, Yano S, Kiyokawa E, Sahai E

    iScience   Vol. 23 ( 9 ) page: 101480   2020.8

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  7. Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma

    Totani Haruhito, Shinjo Keiko, Suzuki Miho, Katsushima Keisuke, Mase Shoko, Masaki Ayako, Ito Asahi, Ri Masaki, Kusumoto Shigeru, Komatsu Hirokazu, Ishida Takashi, Inagaki Hiroshi, Iida Shinsuke, Kondo Yutaka

    ONCOGENE   Vol. 39 ( 35 ) page: 5782 - 5794   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41388-020-01393-x

    Web of Science

    PubMed

  8. Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas

    Ohka Fumiharu, Shinjo Keiko, Deguchi Shoichi, Matsui Yusuke, Okuno Yusuke, Katsushima Keisuke, Suzuki Miho, Kato Akira, Ogiso Noboru, Yamamichi Akane, Aoki Kosuke, Suzuki Hiromichi, Sato Shinya, Rayan Nirmala Arul, Prabhakar Shyam, Goke Jonathan, Shimamura Teppei, Maruyama Reo, Takahashi Satoru, Suzumura Akio, Kimura Hiroshi, Wakabayashi Toshihiko, Zong Hui, Natsume Atsushi, Kondo Yutaka

    CANCER RESEARCH   Vol. 79 ( 19 ) page: 4814 - 4827   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/0008-5472.CAN-19-1272

    Web of Science

    PubMed

  9. ZNF671 DNA methylation as a molecular predictor for the early recurrence of serous ovarian cancer

    Mase Shoko, Shinjo Keiko, Totani Haruhito, Katsushima Keisuke, Arakawa Atsushi, Takahashi Satoru, Lai Hung-Cheng, Lin Ru-Inn, Chan Michael W. Y., Sugiura-Ogasawara Mayumi, Kondo Yutaka

    CANCER SCIENCE   Vol. 110 ( 3 ) page: 1105 - 1116   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13936

    Web of Science

    PubMed

  10. A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR

    Hirano Masaki, Ohka Fumiharu, Maeda Sachi, Chalise Lushun, Yamamichi Akane, Aoki Kosuke, Kato Akira, Tanahashi Kuniaki, Motomura Kazuya, Nishimura Yusuke, Hara Masahito, Shinjo Keiko, Kondo Yutaka, Wakabayashi Toshihiko, Natsume Atsushi

    BRAIN TUMOR PATHOLOGY   Vol. 35 ( 2 ) page: 97 - 105   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-018-0310-7

    Web of Science

    PubMed

  11. Organotypic brain explant culture as a drug evaluation system for malignant brain tumors.

    Minami N, Maeda Y, Shibao S, Arima Y, Ohka F, Kondo Y, Maruyama K, Kusuhara M, Sasayama T, Kohmura E, Saya H, Sampetrean O

    Cancer medicine   Vol. 6 ( 11 ) page: 2635 - 2645   2017.11

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  12. Newly Established Patient-derived Organoid Model of Intracranial Meningioma.

        2021.7

  13. Establishment and characterization of cell lines from human endometrial epithelial and mesenchymal cells from patients with endometriosis Invited Reviewed

    Muraoka A, Osuka S, Kiyono T, Suzuki M, Yokoi A, Murase T, Nishino K, Niimi K, Nakamura T, Goto M, Kajiyama H, Kondo Y, Kikkawa F

    Fertil Steril Sci   Vol. 2 ( 2 ) page: 195 - 205   2020.11

  14. A novel sensitive detection method for DNA methylation in circulating free DNA of pancreatic cancer

    Shinjo Keiko, Hara Kazuo, Nagae Genta, Umeda Takayoshi, Katsushima Keisuke, Suzuki Miho, Murofushi Yoshiteru, Umezu Yuta, Takeuchi Ichiro, Takahashi Satoru, Okuno Yusuke, Matsuo Keitaro, Ito Hidemi, Tajima Shoji, Aburatani Hiroyuki, Yamao Kenji, Kondo Yutaka

    PLOS ONE   Vol. 15 ( 6 ) page: e0233782   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0233782

    Web of Science

    PubMed

  15. H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant

    Maeda Sachi, Ohka Fumiharu, Okuno Yusuke, Aoki Kosuke, Motomura Kazuya, Takeuchi Kazuhito, Kusakari Hironao, Yanagisawa Nobuyuki, Sato Shinya, Yamaguchi Junya, Tanahashi Kuniaki, Hirano Masaki, Kato Akira, Shimizu Hiroyuki, Kitano Yotaro, Yamazaki Shintaro, Yamashita Shinji, Takeshima Hideo, Shinjo Keiko, Kondo Yutaka, Wakabayashi Toshihiko, Natsume Atsushi

    ACTA NEUROPATHOLOGICA COMMUNICATIONS   Vol. 8 ( 1 ) page: 8   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40478-020-0882-4

    Web of Science

    PubMed

  16. Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay

    Murashima Akihiro, Shinjo Keiko, Katsushima Keisuke, Onuki Tetsuo, Kondoh Yasumitsu, Osada Hiroyuki, Kagaya Noritaka, Shin-ya Kazuo, Kimura Hiroshi, Yoshida Minoru, Murakami Shingo, Kondo Yutaka

    JOURNAL OF BIOCHEMISTRY   Vol. 166 ( 1 ) page: 41 - 50   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvz007

    Web of Science

    PubMed

  17. DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes5

    Kondo Naohide, Tohnai Genki, Sahashi Kentaro, Iida Madoka, Kataoka Mayumi, Nakatsuji Hideaki, Tsutsumi Yutaka, Hashizume Atsushi, Adachi Hiroaki, Koike Haruki, Shinjo Keiko, Kondo Yutaka, Sobue Gen, Katsuno Masahisa

    EMBO MOLECULAR MEDICINE   Vol. 11 ( 5 )   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.15252/emmm.201708547

    Web of Science

    PubMed

  18. In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers

    Watanabe Sumiyo, Hayashi Kotaro, Toh Kazuko, Kim Hyun Jin, Liu Xueying, Chaya Hiroyuki, Fukushima Shigeto, Katsushima Keisuke, Kondo Yutaka, Uchida Satoshi, Ogura Satomi, Nomoto Takahiro, Takemoto Hiroyasu, Cabral Horacio, Kinoh Hiroaki, Tanaka Hiroyoshi Y., Kano Mitsunobu R., Matsumoto Yu, Fukuhara Hiroshi, Uchida Shunya, Nangaku Masaomi, Osada Kensuke, Nishiyama Nobuhiro, Miyata Kanjiro, Kataoka Kazunori

    NATURE COMMUNICATIONS   Vol. 10 ( 1 ) page: 1894   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-019-09856-w

    Web of Science

    PubMed

  19. Genome-Epigenome-Senescence: Is TET1 a Caretaker of p53-Injured Lung Cancer Cells?

    Kondo Yutaka

    CANCER RESEARCH   Vol. 79 ( 8 ) page: 1751 - 1752   2019.4

  20. Notch3 is frequently downregulated in oral cancer

    Ichimura Norihisa, Yamamoto Noriyuki, Nishikawa Masaya, Furue Hiroki, Kondo Yutaka, Hibi Hideharu

    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY   Vol. 29 ( 6 ) page: 504-510   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajoms.2017.06.006

    Web of Science

  21. POLYION COMPLEX-MEDIATED INTRAVENOUS DELIVERY OF ANTISENSE OLIGONUCLEOTIDES AGAINST THE NOTCH-REGULATED NON-CODING RNA TUG1 IN GLIOMA

    Natsume Atsushi, Katsushima Keisuke, Ohka Fumiharu, Shinjo Keiko, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka

    NEURO-ONCOLOGY   Vol. 19   page: 265 - 265   2017.11

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  22. Long non-coding RNAs as an epigenetic regulator in human cancers

    Kondo Yutaka, Shinjo Keiko, Katsushima Keisuke

    CANCER SCIENCE   Vol. 108 ( 10 ) page: 1927 - 1933   2017.10

  23. Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis

    Deguchi S., Katsushima K., Hatanaka A., Shinjo K., Ohka F., Wakabayashi T., Zong H., Natsume A., Kondo Y.

    ONCOGENE   Vol. 36 ( 32 ) page: 4629-4640   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/onc.2017.88

    Web of Science

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Books 25

  1. エピゲノムで新たな解明が進む「先天性疾患」

    株式会社メディカルドゥ.遺伝子医学MOOK36  2021 

  2. Non-coding RNAの多様な機能とゲノム安定性維持における役割

    医歯薬出版株式会社  2020 

  3. エピゲノム標的薬

    新城恵子、近藤 豊

    化学同人  2019 

  4. 血中DNAメチル化解析とがん診断

    新城恵子、近藤 豊

    シーエムシー出版  2017 

  5. .DNAメチル化によるがん診断

    間瀬聖子、近藤 豊

    2017 

  6. がん幹細胞とエピゲノム制御

    田崎慶彦、勝島啓祐、木村和哲、近藤 豊

    日本臨牀  2017 

  7. .がん幹細胞を制御するエピゲノム機構―グリオーマのエピゲノム治療に向けて

    大岡史治、近藤 豊

    医歯薬出版株式会社  2015 

  8. Chapter 15: Clinical Significance of Epigenetic Alterations in Glioblastoma

    Ohka F, Natume A, Kondo Y

    Academic Press  2015 

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    Responsible for pages:339-350  

  9. .ヒストンメチル化酵素EZH2の発がんにおける役割と治療標的としての可能性」

    近藤 豊

    羊土社.  2014 

  10. .がんのヒストン異常

    勝島啓佑、近藤 豊

    .シーエムシー出版  2014 

  11. .がん

    近藤 豊、新城恵子

    羊土社  2013 

  12. .脳腫瘍の発生に関わるエピジェネティクス異常

    大岡史治、近藤 豊

    メディカルドゥ  2013 

  13. .がんにおけるエピジェネティクス異常と医療応用

    近藤 豊

    羊土社  2013 

  14. .がん細胞のエピゲノム異常 がんエピゲノム可塑性を標的とした治療法の開発. . .

    近藤 豊

    南山堂  2013 

  15. Genetic and Epigenetic Alterations in Inflammation-Related Cancers ¾ General Mechanisms of Cancers

    Okamoto Y, Kondo Y

    World Scientific Publishing.   2012 

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    Responsible for pages:29-48  

  16. 造血器腫瘍とエピジェネティクス

    近藤 豊

    医薬ジャーナル社  2012 

  17. Clinical implications of epigenetic alterations in human thoracic malignancies: epigenetic alterations in lung cancer

    Shinjo K, Kondo Y

    Methods Mol Biol  2012 

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    Responsible for pages:221-39  

  18. Chapter 12 - Epigenetic Changes in Hepatic Tissues: Evidence of Field Cancerization

    Kondo Y

    Nova Science Publishers.  2010 

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    Responsible for pages:178-192  

  19. エピジェネティクスのがん診断への応用

    新城恵子、近藤 豊

    羊土社  2010 

  20. Chromatin Remodeling

    Kondo Y

    Springer.   2009 

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    Responsible for pages:662-665  

  21. Chapter 5: Inflammation-related aberrant patterns of DNA methylation: detection and role in epigenetic deregulation of cancer cell transcriptome

    Suzuki H, Toyota M, Kondo Y, Shinomura Y

    Humana Press  2009 

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    Responsible for pages:55-69  

  22. Pyrosequencing (パイロシークエンス法)

    近藤 豊..

    羊土社  2008 

  23. Chapter 5: Chromatin immunoprecipitation for microarray analysis

    Kondo Y, Issa JPJ

    DNA Press  2006 

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    Responsible for pages:77-88  

  24. ヒストンのメチル化とアセチル化

    近藤 豊

    羊土社  2004 

  25. 肝炎

    近藤 豊、溝上雅史.

    医薬ジャーナル社.   1997 

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Presentations 21

  1. 「エピジェネティクス」

    近藤 豊

    第80回日本癌学会学術総会  2021.9.30 

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    Event date: 2021.9 - 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

  2. 新規LSD 1阻害剤による脳腫瘍治療効果とその機序の解明

    近藤 豊

    第80回日本癌学会学術総会  2021.9.30 

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    Event date: 2021.9 - 2021.10

    Language:Japanese   Presentation type:Poster presentation  

  3. 脳転移におけるグリアネットワークの破綻

    近藤 豊

    第80回日本癌学会学術総会  2021.10.1 

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    Event date: 2021.9 - 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

  4. 長鎖非翻訳RNA TUG1はR-loopを解消しがん細胞の増殖を促進する

    近藤 豊

    第80回日本癌学会学術総会  2021.9.30 

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    Event date: 2021.9 - 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

  5. がんの起源を探って

    近藤 豊

    第80回日本癌学会学術総会  2021.10.2 

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    Event date: 2021.9 - 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

  6. がん細胞の維持に関わる長鎖非翻訳RNAの解析と治療への応用

    近藤 豊

    第17回日本病理学会カンファレンス  2021.8.21 

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    Event date: 2021.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  7. エピジェネティックな間質細胞の変化が増殖性病変を誘導する

    近藤 豊

    AMED 次世代がん医療創生研究事業 「微小環境多様性に連動する難治がんの分子遺伝学的多様性創成機構の解明と新たながん治療法・予測医療技術の開発」班 令和3年度 第1回班会議  2021.7.24 

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    Event date: 2021.7

    Language:Japanese  

  8. 細胞のゲノム調節分子としての長鎖非翻訳RN

    近藤 豊

    生化学会北陸支部シンポジウム  2021.6.5 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  9. 「ゲノム・エピゲノム」新規LSD1阻害剤の開発

    近藤 豊

    第25回日本がん分子標的治療学会学術集会  2021.5.26 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation (general)  

  10. ゲノム不安定化機構研究の新潮流

    近藤 豊

    第49回大会日本環境変異現学会  2020.11.26 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  11. がんの進展に関わるエピジェネティクスの解明と創薬への応用

    近藤 豊

    第24回日本がん分子標的治療学会学術集会  2020.10.7 

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    Event date: 2020.10

    Venue:徳島  

  12. 神経膠腫のエピゲノム解読と新規治療法の開発

    近藤 豊

    第79回日本癌学会学術総会  2020.10.1 

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    Event date: 2020.10

    Venue:広島  

  13. がん細胞のDNA複製ストレスを調節する長鎖非翻訳RNAの機能解明

    近藤 豊

    第93回日本生化学会大会  2020.9.14 

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    Event date: 2020.9

  14. LncRNA TUG1 is a Potent Therapeutic Target Via Enhancing 5-FU Sensitivity in Pancreatic Cancer Invited International conference

    Yutaka Kondo

    The Translational Medicine Forum 

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    Event date: 2019.12

    Language:English   Presentation type:Oral presentation (keynote)  

    Country:China  

  15. Long non-coding RNA as an essential regulator of DNA replication stress in human malignancies Invited

    近藤 豊

    HIGO最先端研究セミナー(熊本大学リエゾンラボ研究会)  2019.12.11 

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    Event date: 2019.12

    Venue:熊本  

  16. Anti-sense Oligonucleotides-based Nucleic-acid Therapeutics Targeting Long Non-coding RNA in Human Cancers Invited International conference

    Yutaka Kondo

    8th Annual Conference of International Chemical Biology Society 

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    Event date: 2019.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:India  

  17. Long non-coding RNA as an essential regulator of DNA replication in cancers Invited

    近藤 豊

    Tohoku Forum for Creativity (Thematic program 2019), Cancer – from Biology to Acceptance Cancer Etiology  2019.9.24 

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    Event date: 2019.9

    Venue:仙台  

  18. Long non-coding RNA as an essential regulator of DNA replication for maintenance of cancer cells Invited International conference

    Yutaka Kondo

    8th Annual Conference of International Chemical Biology Society 

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    Event date: 2019.9

    Language:English   Presentation type:Oral presentation (keynote)  

    Country:Singapore  

  19. がん細胞におけるゲノム調節分子としての長鎖非翻訳RNA Invited

    近藤 豊

    第56回日本臨床分子医学会学術集会スポンサードセミナー1  2019.4.26 

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    Event date: 2019.4

    Venue:名古屋  

  20. Cancer Epigenetics – Strategies for Clinical Therapy Invited International conference

    Yutaka Kondo

    4th National Neuroscience Institute (NNI) Neuro-Oncology Symposium 

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (keynote)  

    Country:Singapore  

  21. Tumorigenic roles of lncRNAs in human gliomas Invited International conference

    Yutaka Kondo

    AACR Annual Meeting 2018 

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    Event date: 2018.4

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:United States  

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KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. DNA損傷時のエピゲノム修復における長鎖非翻訳RNAの役割と発がんへの関与

    Grant number:20K20598  2020.7 - 2023.3

    科学研究費補助金  挑戦的研究(開拓)

    近藤 豊

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    Authorship:Principal investigator 

    Grant amount:\26000000 ( Direct Cost: \20000000 、 Indirect Cost:\6000000 )

    ゲノム、およびエピゲノム安定性の維持は細胞の生存や個体の発生において極めて重要であり、その破綻はがん等の疾患の原因となる。ゲノム安定性の維持機構については長年の研究により詳細なメカニズムが解明されてきた。一方でエピゲノムの安定性については、DNA損傷時にエピゲノム情報が失われたり傷ついた際に、どのようにオリジナルのエピゲノム修飾が修復・維持されるのか(エビゲノム修復機構)については解明が進んでいない。本申請課題では、DNA損傷によってDNAメチル化情報やヒストンタンパク質の脱離した領域におけるエピゲノム修復機構として、lncRNAを介する機構を提起し、エピゲノム安定性に関して解明を試みる。

  2. A study of mechanism of resolving DNA replication stress by long non-coding RNA in cancer cell

    Grant number:20H03511  2020.4 - 2023.3

    Kondo Yutaka

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    Authorship:Principal investigator 

    Grant amount:\17940000 ( Direct Cost: \13800000 、 Indirect Cost:\4140000 )

  3. 消化器がん化学療法における新規バイオマーカーとしてのDNAメチル化の探索的研究

    Grant number:20K08328  2020.4 - 2023.3

    科学研究費補助金  基盤研究(C)

    近藤 豊

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    Authorship:Coinvestigator(s) 

  4. 膵臓がんのがん間質ダイナミクスを制御する機能性RNAの同定と標的化

    Grant number:19KK0209  2019.10 - 2022.3

    科学研究費補助金  国際共同研究加速基金(国際共同研究強化(B))

    近藤 豊

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    Authorship:Coinvestigator(s) 

  5. Long non-coding RNA as an epigenetic modulator in cancer cells

    Grant number:17H03582  2017.4 - 2020.3

    Kondo Yutaka

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    Authorship:Principal investigator 

    Grant amount:\18070000 ( Direct Cost: \13900000 、 Indirect Cost:\4170000 )

    We identified that TUG1 (taurine upregulated gene 1) is an indispensable long noncoding RNA (lncRNA) to regulate intrinsic DNA replication stress (RS)/ DNA repair in cancer cells. When replication was disrupted, the ATR signaling pathway was activated and immediately induced transcription of TUG1. Mechanistically, TUG1 promoted recruitment of replication protein A (RPA) to the replication forks. Our data reveal a novel spatiotemporal role of TUG1 as an indispensable molecule to relieve RS in cancer cells and provide a strong rationale for targeting TUG1 as a specific and potent therapeutic approach for cancer treatment.

 

Teaching Experience (On-campus) 4

  1. Distinctive Educational Program - Cancer science course

    2021

  2. Molecular Pathology

    2021

  3. Distinctive Educational Program - Cancer science course

    2020

  4. Molecular Pathology

    2020