Organization
Graduate School of Medicine Center for Neurological Diseases and Cance Division Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor
KONDO Yutaka
Degree 1
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医学博士 （ 2000.3 名古屋市立大学 ）
Research Interests 4
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疾患研究
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腫瘍生物学
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非翻訳RNA
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エピジェネティクス
Research Areas 1
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Life Science / Tumor biology
Current Research Project and SDGs 1
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がんエピゲノムの解明
Education 2
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Nagoya City University Graduate School, Division of Medicine
1996.4 - 2000.3
Country： Japan
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Nagoya City University Faculty of Medicine
1984.4 - 1990.3
Country： Japan
Papers 44
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Mutation of the SWI/SNF complex component Smarce1 decreases nucleosome stability in embryonic stem cells and impairs differentiation.
Kashiwagi K, Yoshida J, Kimura H, Shinjo K, Kondo Y, Horie K
Journal of cell science Vol. 137 ( 6 ) 2024.3
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Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR.
Ishibashi K, Ichinose T, Kadokawa R, Mizutani R, Iwabuchi S, Togi S, Ura H, Tange S, Shinjo K, Nakayama J, Nanjo S, Niida Y, Kondo Y, Hashimoto S, Sahai E, Yano S, Nakada M, Hirata E
Developmental cell Vol. 59 ( 5 ) page： 579 - 594.e6 2024.3
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Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties.
Das ND, Chang JC, Hon CC, Kelly ST, Ito S, Lizio M, Kaczkowski B, Watanabe H, Katsushima K, Natsume A, Koseki H, Kondo Y, Minoda A, Umehara T
BMC genomics Vol. 24 ( 1 ) page： 574 2023.9
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TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation.
Suzuki MM, Iijima K, Ogami K, Shinjo K, Murofushi Y, Xie J, Wang X, Kitano Y, Mamiya A, Kibe Y, Nishimura T, Ohka F, Saito R, Sato S, Kobayashi J, Yao R, Miyata K, Kataoka K, Suzuki HI, Kondo Y
Nature communications Vol. 14 ( 1 ) page： 4521 2023.8
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Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts.
Muraoka A, Suzuki M, Hamaguchi T, Watanabe S, Iijima K, Murofushi Y, Shinjo K, Osuka S, Hariyama Y, Ito M, Ohno K, Kiyono T, Kyo S, Iwase A, Kikkawa F, Kajiyama H, Kondo Y
Science translational medicine Vol. 15 ( 700 ) page： eadd1531 2023.6
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Rapid detection of the MYD88 L265P mutation for pre- and intra-operative diagnosis of primary central nervous system lymphoma.
Yamaguchi J, Ohka F, Kitano Y, Maeda S, Motomura K, Aoki K, Takeuchi K, Nagata Y, Hattori H, Tsujiuchi T, Motomura A, Nishikawa T, Kibe Y, Shinjo K, Kondo Y, Saito R
Cancer science Vol. 114 ( 6 ) page： 2544 - 2551 2023.6
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CD79B Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma.
Yamaguchi J, Ohka F, Lushun C, Motomura K, Aoki K, Takeuchi K, Nagata Y, Ito S, Mizutani N, Ohno M, Suzaki N, Takasu S, Seki Y, Kano T, Wakabayashi K, Oyama H, Kurahashi S, Tanahashi K, Hirano M, Shimizu H, Kitano Y, Maeda S, Yamazaki S, Wakabayashi T, Kondo Y, Natsume A, Saito R
Cancer medicine Vol. 12 ( 6 ) page： 7116 - 7126 2023.3
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Long non-coding RNA lnc-CHAF1B-3 promotes renal interstitial fibrosis by regulating EMT-related genes in renal proximal tubular cells. Invited Reviewed
Mol Ther Nucleic Acids 2022.12
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CA19-9 in Combination with Methylated HOXA1 and SST Is Useful to Diagnose Stage I Pancreatic Cancer
Yutaka Suehiro , Shigeyuki Suenaga , Yuki Kunimune , Shoko Yada . Kaori Hamamoto , Takanori Tsuyama , Shogo Amano , Hiroto Matsui , Shingo Higaki , Ikuei Fujii, Chieko Suzuki , Tomomi Hoshida , Toshihiko Matsumoto , Yuko Fujimoto , Seiji Kaino , Keiko Shinjo , Yutaka Kondo , Isao Sakaida , Taro Takami , Hiroaki Nagano , Takahiro Yamasaki
Oncology 2022.10
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Characteristic DNA methylation profiles of chorionic villi in recurrent miscarriage.
Matsumoto Y, Shinjo K, Mase S, Fukuyo M, Aoki K, Ozawa F, Yoshihara H, Goto S, Kitaori T, Ozaki Y, Takahashi S, Kaneda A, Sugiura-Ogasawara M, Kondo Y
Scientific reports Vol. 12 ( 1 ) page： 11673 2022.7
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Newly established patient-derived organoid model of intracranial meningioma.
Yamazaki S, Ohka F, Hirano M, Shiraki Y, Motomura K, Tanahashi K, Tsujiuchi T, Motomura A, Aoki K, Shinjo K, Murofushi Y, Kitano Y, Maeda S, Kato A, Shimizu H, Yamaguchi J, Adilijiang A, Wakabayashi T, Saito R, Enomoto A, Kondo Y, Natsume A
Neuro-oncology Vol. 23 ( 11 ) page： 1936 - 1948 2021.11
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Cancer-specific targeting of taurine upregulated gene 1 enhances the effects of chemotherapy in pancreatic cancer Invited Reviewed
Tasaki T, Suzuki M, Katsushima K, Shinjo K, Iijima K, Murofushi Y, Naiki-Ito A, Hayashi K, Qiu C, Takahashi A, Tanaka Y, Kawaguchi T, Sugawara M, Kataoka T, Taito M, Miyata K, Kataoka K, Noda T, Gao W, Kataoka H, Takahashi S, Kimura K, Kondo Y
Vol. 81 ( 7 ) page： 1654 - 1666 2021.4
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Peritoneal Lavage Tumor DNA as a Novel Biomarker for Predicting Peritoneal Recurrence in Pancreatic Ductal Adenocarcinoma.
Suenaga M, Fujii T, Yamada S, Hayashi M, Shinjo K, Takami H, Niwa Y, Sonohara F, Shimizu D, Kanda M, Kobayashi D, Tanaka C, Nakayama G, Koike M, Fujiwara M, Kondo Y, Kodera Y
Annals of surgical oncology Vol. 28 ( 4 ) page： 2277 - 2286 2021.4
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Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder Invited Reviewed
Kato H, Kushima I, Mori D, Yoshimi A, Branko A, Nawa Y, Toyama M, Furuta S, Yanjie Yu, Ishizuka K, Kimura H, Arioka Y, Tsujimura K, Morikawa M, Okada T, Inada T, Nakatochi M, Shinjo K, Kondo Y, Kaibuchi K, Funabiki Y, Kimura R, Suzuki T, Yamakawa K, Ikeda M, Iwata N, Takahashi T, Suzuki M, Okahisa Y, Takaki M, Egawa J, Someya T, Ozaki N
Transl Psychiatry Vol. 10 ( 1 ) page： 421 - 421 2020.12
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Establishment and characterization of cell lines from human endometrial epithelial and mesenchymal cells from patients with endometriosis.
Muraoka A, Osuka S, Kiyono T, Suzuki M, Yokoi A, Murase T, Nishino K, Niimi K, Nakamura T, Goto M, Kajiyama H, Kondo Y, Kikkawa F
F&S science Vol. 1 ( 2 ) page： 195 - 205 2020.11
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The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells.
Hirata E, Ishibashi K, Kohsaka S, Shinjo K, Kojima S, Kondo Y, Mano H, Yano S, Kiyokawa E, Sahai E
iScience Vol. 23 ( 9 ) page： 101480 2020.9
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Long non-coding RNA: A recently accentuated molecule in chemoresistance in cancer.
Peng Y, Tang D, Zhao M, Kajiyama H, Kikkawa F, Kondo Y
Cancer metastasis reviews Vol. 39 ( 3 ) page： 825 - 835 2020.9
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Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma
Totani Haruhito, Shinjo Keiko, Suzuki Miho, Katsushima Keisuke, Mase Shoko, Masaki Ayako, Ito Asahi, Ri Masaki, Kusumoto Shigeru, Komatsu Hirokazu, Ishida Takashi, Inagaki Hiroshi, Iida Shinsuke, Kondo Yutaka
ONCOGENE Vol. 39 ( 35 ) page： 5782 - 5794 2020.8
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A novel sensitive detection method for DNA methylation in circulating free DNA of pancreatic cancer
Shinjo Keiko, Hara Kazuo, Nagae Genta, Umeda Takayoshi, Katsushima Keisuke, Suzuki Miho, Murofushi Yoshiteru, Umezu Yuta, Takeuchi Ichiro, Takahashi Satoru, Okuno Yusuke, Matsuo Keitaro, Ito Hidemi, Tajima Shoji, Aburatani Hiroyuki, Yamao Kenji, Kondo Yutaka
PLOS ONE Vol. 15 ( 6 ) page： e0233782 2020
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Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas
Ohka Fumiharu, Shinjo Keiko, Deguchi Shoichi, Matsui Yusuke, Okuno Yusuke, Katsushima Keisuke, Suzuki Miho, Kato Akira, Ogiso Noboru, Yamamichi Akane, Aoki Kosuke, Suzuki Hiromichi, Sato Shinya, Rayan Nirmala Arul, Prabhakar Shyam, Goke Jonathan, Shimamura Teppei, Maruyama Reo, Takahashi Satoru, Suzumura Akio, Kimura Hiroshi, Wakabayashi Toshihiko, Zong Hui, Natsume Atsushi, Kondo Yutaka
CANCER RESEARCH Vol. 79 ( 19 ) page： 4814 - 4827 2019.10
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Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay
Murashima Akihiro, Shinjo Keiko, Katsushima Keisuke, Onuki Tetsuo, Kondoh Yasumitsu, Osada Hiroyuki, Kagaya Noritaka, Shin-ya Kazuo, Kimura Hiroshi, Yoshida Minoru, Murakami Shingo, Kondo Yutaka
JOURNAL OF BIOCHEMISTRY Vol. 166 ( 1 ) page： 41 - 50 2019.7
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ZNF671 DNA methylation as a molecular predictor for the early recurrence of serous ovarian cancer
Mase Shoko, Shinjo Keiko, Totani Haruhito, Katsushima Keisuke, Arakawa Atsushi, Takahashi Satoru, Lai Hung-Cheng, Lin Ru-Inn, Chan Michael W. Y., Sugiura-Ogasawara Mayumi, Kondo Yutaka
CANCER SCIENCE Vol. 110 ( 3 ) page： 1105 - 1116 2019.3
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A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR
Hirano Masaki, Ohka Fumiharu, Maeda Sachi, Chalise Lushun, Yamamichi Akane, Aoki Kosuke, Kato Akira, Tanahashi Kuniaki, Motomura Kazuya, Nishimura Yusuke, Hara Masahito, Shinjo Keiko, Kondo Yutaka, Wakabayashi Toshihiko, Natsume Atsushi
BRAIN TUMOR PATHOLOGY Vol. 35 ( 2 ) page： 97 - 105 2018.4
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Organotypic brain explant culture as a drug evaluation system for malignant brain tumors.
Minami N, Maeda Y, Shibao S, Arima Y, Ohka F, Kondo Y, Maruyama K, Kusuhara M, Sasayama T, Kohmura E, Saya H, Sampetrean O
Cancer medicine Vol. 6 ( 11 ) page： 2635 - 2645 2017.11
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Rapid detection of the MYD88 L265P mutation for pre- and intra-operative diagnosis of primary central nervous system lymphoma
Cancer science 2023.3
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Rapid detection of the MYD88 L265P mutation for pre- and intra-operative diagnosis of primary central nervous system lymphoma
Cancer science 2023.3
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Single-cell RNA sequencing reveals tumor heterogeneity, microenvironment, and drug-resistance mechanisms of recurrent glioblastoma
Cancer Science 2023.2
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Single-cell RNA sequencing reveals tumor heterogeneity, microenvironment, and drug-resistance mechanisms of recurrent glioblastoma
Cancer Science 2023.2
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Long non-coding RNA lnc-CHAF1B-3 promotes renal interstitial fibrosis by regulating EMT-related genes in renal proximal tubular cells.
Mol Ther Nucleic Acids 2022.12
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Long non-coding RNA lnc-CHAF1B-3 promotes renal interstitial fibrosis by regulating EMT-related genes in renal proximal tubular cells.
Mol Ther Nucleic Acids 2022.12
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CD79B Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma. Invited Reviewed
Cancer Medicine 2022.12
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CD79B Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma.
Cancer Medicine 2022.12
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CD79B Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma.
Cancer Medicine 2022.12
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CD79B Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma. Invited Reviewed
Cancer Medicine 2022.12
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Newly Established Patient-derived Organoid Model of Intracranial Meningioma.
2021.7
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Establishment and characterization of cell lines from human endometrial epithelial and mesenchymal cells from patients with endometriosis Invited Reviewed
Muraoka A, Osuka S, Kiyono T, Suzuki M, Yokoi A, Murase T, Nishino K, Niimi K, Nakamura T, Goto M, Kajiyama H, Kondo Y, Kikkawa F
Fertil Steril Sci Vol. 2 ( 2 ) page： 195 - 205 2020.11
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H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant
Maeda Sachi, Ohka Fumiharu, Okuno Yusuke, Aoki Kosuke, Motomura Kazuya, Takeuchi Kazuhito, Kusakari Hironao, Yanagisawa Nobuyuki, Sato Shinya, Yamaguchi Junya, Tanahashi Kuniaki, Hirano Masaki, Kato Akira, Shimizu Hiroyuki, Kitano Yotaro, Yamazaki Shintaro, Yamashita Shinji, Takeshima Hideo, Shinjo Keiko, Kondo Yutaka, Wakabayashi Toshihiko, Natsume Atsushi
ACTA NEUROPATHOLOGICA COMMUNICATIONS Vol. 8 ( 1 ) page： 8 2020.2
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DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes5
Kondo Naohide, Tohnai Genki, Sahashi Kentaro, Iida Madoka, Kataoka Mayumi, Nakatsuji Hideaki, Tsutsumi Yutaka, Hashizume Atsushi, Adachi Hiroaki, Koike Haruki, Shinjo Keiko, Kondo Yutaka, Sobue Gen, Katsuno Masahisa
EMBO MOLECULAR MEDICINE Vol. 11 ( 5 ) 2019.5
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In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
Watanabe Sumiyo, Hayashi Kotaro, Toh Kazuko, Kim Hyun Jin, Liu Xueying, Chaya Hiroyuki, Fukushima Shigeto, Katsushima Keisuke, Kondo Yutaka, Uchida Satoshi, Ogura Satomi, Nomoto Takahiro, Takemoto Hiroyasu, Cabral Horacio, Kinoh Hiroaki, Tanaka Hiroyoshi Y., Kano Mitsunobu R., Matsumoto Yu, Fukuhara Hiroshi, Uchida Shunya, Nangaku Masaomi, Osada Kensuke, Nishiyama Nobuhiro, Miyata Kanjiro, Kataoka Kazunori
NATURE COMMUNICATIONS Vol. 10 ( 1 ) page： 1894 2019.4
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Genome-Epigenome-Senescence: Is TET1 a Caretaker of p53-Injured Lung Cancer Cells?
Kondo Yutaka
CANCER RESEARCH Vol. 79 ( 8 ) page： 1751 - 1752 2019.4
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Notch3 is frequently downregulated in oral cancer
Ichimura Norihisa, Yamamoto Noriyuki, Nishikawa Masaya, Furue Hiroki, Kondo Yutaka, Hibi Hideharu
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY Vol. 29 ( 6 ) page： 504-510 2017.11
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POLYION COMPLEX-MEDIATED INTRAVENOUS DELIVERY OF ANTISENSE OLIGONUCLEOTIDES AGAINST THE NOTCH-REGULATED NON-CODING RNA TUG1 IN GLIOMA
Natsume Atsushi, Katsushima Keisuke, Ohka Fumiharu, Shinjo Keiko, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka
NEURO-ONCOLOGY Vol. 19 page： 265 - 265 2017.11
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Long non-coding RNAs as an epigenetic regulator in human cancers
Kondo Yutaka, Shinjo Keiko, Katsushima Keisuke
CANCER SCIENCE Vol. 108 ( 10 ) page： 1927 - 1933 2017.10
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Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis
Deguchi S., Katsushima K., Hatanaka A., Shinjo K., Ohka F., Wakabayashi T., Zong H., Natsume A., Kondo Y.
ONCOGENE Vol. 36 ( 32 ) page： 4629-4640 2017.8
Books 25
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エピゲノムで新たな解明が進む「先天性疾患」
株式会社メディカルドゥ.遺伝子医学MOOK36 2021
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Non-coding RNAの多様な機能とゲノム安定性維持における役割
医歯薬出版株式会社 2020
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エピゲノム標的薬
新城恵子、近藤 豊
化学同人 2019
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がん幹細胞とエピゲノム制御
田崎慶彦、勝島啓祐、木村和哲、近藤 豊
日本臨牀 2017
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.DNAメチル化によるがん診断
間瀬聖子、近藤 豊
2017
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血中ＤＮＡメチル化解析とがん診断
新城恵子、近藤 豊
シーエムシー出版 2017
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Chapter 15: Clinical Significance of Epigenetic Alterations in Glioblastoma
Ohka F, Natume A, Kondo Y
Academic Press 2015
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.がん幹細胞を制御するエピゲノム機構―グリオーマのエピゲノム治療に向けて
大岡史治、近藤 豊
医歯薬出版株式会社 2015
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.ヒストンメチル化酵素EZH2の発がんにおける役割と治療標的としての可能性」
近藤 豊
羊土社. 2014
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.がんのヒストン異常
勝島啓佑、近藤 豊
.シーエムシー出版 2014
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.がん
近藤 豊、新城恵子
羊土社 2013
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.脳腫瘍の発生に関わるエピジェネティクス異常
大岡史治、近藤 豊
メディカルドゥ 2013
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.がんにおけるエピジェネティクス異常と医療応用
近藤 豊
羊土社 2013
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.がん細胞のエピゲノム異常 がんエピゲノム可塑性を標的とした治療法の開発. . .
近藤 豊
南山堂 2013
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Genetic and Epigenetic Alterations in Inflammation-Related Cancers ¾ General Mechanisms of Cancers
Okamoto Y, Kondo Y
World Scientific Publishing. 2012
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造血器腫瘍とエピジェネティクス
近藤 豊
医薬ジャーナル社 2012
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Clinical implications of epigenetic alterations in human thoracic malignancies: epigenetic alterations in lung cancer
Shinjo K, Kondo Y
Methods Mol Biol 2012
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Chapter 12 - Epigenetic Changes in Hepatic Tissues: Evidence of Field Cancerization
Kondo Y
Nova Science Publishers. 2010
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エピジェネティクスのがん診断への応用
新城恵子、近藤 豊
羊土社 2010
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Chapter 5: Inflammation-related aberrant patterns of DNA methylation: detection and role in epigenetic deregulation of cancer cell transcriptome
Suzuki H, Toyota M, Kondo Y, Shinomura Y
Humana Press 2009
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Chromatin Remodeling
Kondo Y
Springer. 2009
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Pyrosequencing （パイロシークエンス法)
近藤 豊..
羊土社 2008
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Chapter 5: Chromatin immunoprecipitation for microarray analysis
Kondo Y, Issa JPJ
DNA Press 2006
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ヒストンのメチル化とアセチル化
近藤 豊
羊土社 2004
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肝炎
近藤 豊、溝上雅史.
医薬ジャーナル社. 1997
Presentations 23
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LSD1を標的した脳腫瘍の新規治療薬の開発
第27回日本がん分子標的治療学会学術集 2023.6.22
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長鎖非翻訳RNA ECONEXINによる大脳皮質の発生制御機構
2022年度先端モデル動物支援プラットフォーム成果発表会 2023.2.9
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「エピジェネティクス」
近藤 豊
第80回日本癌学会学術総会 2021.9.30
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新規LSD 1阻害剤による脳腫瘍治療効果とその機序の解明
近藤 豊
第80回日本癌学会学術総会 2021.9.30
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脳転移におけるグリアネットワークの破綻
近藤 豊
第80回日本癌学会学術総会 2021.10.1
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長鎖非翻訳RNA TUG1はR-loopを解消しがん細胞の増殖を促進する
近藤 豊
第80回日本癌学会学術総会 2021.9.30
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がんの起源を探って
近藤 豊
第80回日本癌学会学術総会 2021.10.2
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がん細胞の維持に関わる長鎖非翻訳RNAの解析と治療への応用
近藤 豊
第17回日本病理学会カンファレンス 2021.8.21
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エピジェネティックな間質細胞の変化が増殖性病変を誘導する
近藤 豊
AMED 次世代がん医療創生研究事業 「微小環境多様性に連動する難治がんの分子遺伝学的多様性創成機構の解明と新たながん治療法・予測医療技術の開発」班 令和３年度 第1回班会議 2021.7.24
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細胞のゲノム調節分子としての長鎖非翻訳RN
近藤 豊
生化学会北陸支部シンポジウム 2021.6.5
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「ゲノム・エピゲノム」新規LSD1阻害剤の開発
近藤 豊
第25回日本がん分子標的治療学会学術集会 2021.5.26
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ゲノム不安定化機構研究の新潮流
近藤 豊
第49回大会日本環境変異現学会 2020.11.26
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がんの進展に関わるエピジェネティクスの解明と創薬への応用
近藤 豊
第24回日本がん分子標的治療学会学術集会 2020.10.7
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神経膠腫のエピゲノム解読と新規治療法の開発
近藤 豊
第79回日本癌学会学術総会 2020.10.1
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がん細胞のDNA複製ストレスを調節する長鎖非翻訳RNAの機能解明
近藤 豊
第93回日本生化学会大会 2020.9.14
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LncRNA TUG1 is a Potent Therapeutic Target Via Enhancing 5-FU Sensitivity in Pancreatic Cancer Invited International conference
Yutaka Kondo
The Translational Medicine Forum
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Long non-coding RNA as an essential regulator of DNA replication stress in human malignancies Invited
近藤 豊
HIGO最先端研究セミナー（熊本大学リエゾンラボ研究会） 2019.12.11
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Anti-sense Oligonucleotides-based Nucleic-acid Therapeutics Targeting Long Non-coding RNA in Human Cancers Invited International conference
Yutaka Kondo
8th Annual Conference of International Chemical Biology Society
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Long non-coding RNA as an essential regulator of DNA replication in cancers Invited
近藤 豊
Tohoku Forum for Creativity (Thematic program 2019), Cancer – from Biology to Acceptance Cancer Etiology 2019.9.24
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Long non-coding RNA as an essential regulator of DNA replication for maintenance of cancer cells Invited International conference
Yutaka Kondo
8th Annual Conference of International Chemical Biology Society
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がん細胞におけるゲノム調節分子としての長鎖非翻訳RNA Invited
近藤 豊
第56回日本臨床分子医学会学術集会スポンサードセミナー１ 2019.4.26
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Cancer Epigenetics – Strategies for Clinical Therapy Invited International conference
Yutaka Kondo
4th National Neuroscience Institute (NNI) Neuro-Oncology Symposium
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Tumorigenic roles of lncRNAs in human gliomas Invited International conference
Yutaka Kondo
AACR Annual Meeting 2018
KAKENHI (Grants-in-Aid for Scientific Research) 5
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DNA損傷時のエピゲノム修復における長鎖非翻訳RNAの役割と発がんへの関与
Grant number：20K20598 2020.7 - 2023.3
科学研究費補助金 挑戦的研究(開拓)
近藤 豊
Authorship：Principal investigator
Grant amount：\26000000 （ Direct Cost: \20000000 、 Indirect Cost：\6000000 ）
ゲノム、およびエピゲノム安定性の維持は細胞の生存や個体の発生において極めて重要であり、その破綻はがん等の疾患の原因となる。ゲノム安定性の維持機構については長年の研究により詳細なメカニズムが解明されてきた。一方でエピゲノムの安定性については、DNA損傷時にエピゲノム情報が失われたり傷ついた際に、どのようにオリジナルのエピゲノム修飾が修復・維持されるのか（エビゲノム修復機構）については解明が進んでいない。本申請課題では、DNA損傷によってDNAメチル化情報やヒストンタンパク質の脱離した領域におけるエピゲノム修復機構として、lncRNAを介する機構を提起し、エピゲノム安定性に関して解明を試みる。
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A study of mechanism of resolving DNA replication stress by long non-coding RNA in cancer cell
Grant number：20H03511 2020.4 - 2023.3
Kondo Yutaka
Authorship：Principal investigator
Grant amount：\17940000 （ Direct Cost: \13800000 、 Indirect Cost：\4140000 ）
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消化器がん化学療法における新規バイオマーカーとしてのDNAメチル化の探索的研究
Grant number：20K08328 2020.4 - 2023.3
科学研究費補助金 基盤研究(C)
近藤 豊
Authorship：Coinvestigator(s)
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膵臓がんのがん間質ダイナミクスを制御する機能性RNAの同定と標的化
Grant number：19KK0209 2019.10 - 2022.3
科学研究費補助金 国際共同研究加速基金（国際共同研究強化(B)）
近藤 豊
Authorship：Coinvestigator(s)
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Long non-coding RNA as an epigenetic modulator in cancer cells
Grant number：17H03582 2017.4 - 2020.3
Kondo Yutaka
Authorship：Principal investigator
Grant amount：\18070000 （ Direct Cost: \13900000 、 Indirect Cost：\4170000 ）
We identified that TUG1 (taurine upregulated gene 1) is an indispensable long noncoding RNA (lncRNA) to regulate intrinsic DNA replication stress (RS)/ DNA repair in cancer cells. When replication was disrupted, the ATR signaling pathway was activated and immediately induced transcription of TUG1. Mechanistically, TUG1 promoted recruitment of replication protein A (RPA) to the replication forks. Our data reveal a novel spatiotemporal role of TUG1 as an indispensable molecule to relieve RS in cancer cells and provide a strong rationale for targeting TUG1 as a specific and potent therapeutic approach for cancer treatment.
Teaching Experience (On-campus) 4
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Molecular Pathology
2021
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Distinctive Educational Program - Cancer science course
2021
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Distinctive Educational Program - Cancer science course
2020
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Molecular Pathology
2020