Updated on 2024/09/10

写真a

 
AOKI Kosuke
 
Organization
Graduate School of Medicine Designated lecturer
Title
Designated lecturer

Degree 1

  1. 博士(医学) ( 2017.10   名古屋大学 ) 

Research Interests 1

  1. 脳腫瘍

Education 2

  1. Nagoya University   Faculty of Medicine   Department of Neurosurgery

    2011.4 - 2015.3

      More details

    Country: Japan

  2. Nagoya University   Faculty of Medicine

    2000.4 - 2006.3

      More details

    Country: Japan

Professional Memberships 4

  1. 脳神経外科学会

  2. 脳腫瘍学会

  3. Society for NeuroOncology

  4. 日本癌学会

Awards 5

  1. 第38回日本脳腫瘍学会学術集会 Top Scoring Abstract賞

    2020.11   日本脳腫瘍学会  

     More details

    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  2. 第20回日本分子脳神経外科学会賞

    2019.8   日本分子脳神経外科学会賞  

     More details

    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  3. 平成30年名古屋大学医師会研究奨励賞

    2018.11   名古屋大学医師会  

     More details

    Country:Japan

  4. 第85回日本脳神経外科学会中部支部学術集会 優秀論文賞受賞

    2013   日本脳神経外科学会中部支部学術集会  

     More details

    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  5. 第75回日本脳神経外科学会中部支部学術集会 優秀論文賞受賞

    2008   日本脳神経外科学会中部支部学術集会  

     More details

    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

 

Papers 73

  1. Mutational landscape and clonal architecture in grade Ⅱ and Ⅲ gliomas. Reviewed

    Suzuki H, Aoki K, Chiba K, Sato Y, Shiozawa Y, Shiraishi Y, Shimamura T, Niida A, Motomura K, Ohka F, Yamamoto T, Tanahashi K, Ranjit M, Wakabayashi T, Yoshizato T, Kataoka K, Yoshida K, Nagata Y, Sato-Otsubo A, Tanaka H, Sanada M, Kondo Y, Nakamura H, Mizoguchi M, Abe T, Muragaki Y, Watanabe R, Ito I, Miyano S, Natsume A, Ogawa S.

    Nature Genetics   Vol. 47 ( 5 ) page: 458-468   2015.8

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ng.3273

    PubMed

  2. Prognostic relevance of genetic alterations in diffuse lower-grade gliomas Reviewed

    Aoki K, Nakamura H, Suzuki H, Matsuo K, Kataoka K, Shimamura T, Motomura K, Ohka F, Shiina S, Yamamoto T, Nagata Y, Yoshizato T, Mizoguchi M, Abe T, Momii Y, Muragaki Y, Watanabe R, Ito I, Sanada M, Yajima H, Morita N, Takeuchi I, Miyano S, Wakabayashi T, Ogawa S, Natsume A

    Neuro-oncology   Vol. 20 ( 1 ) page: 66 - 77   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/neuonc/nox132

    Web of Science

    PubMed

  3. Overview of DNA methylation in adult diffuse gliomas

    Aoki Kosuke, Natsume Atsushi

    BRAIN TUMOR PATHOLOGY   Vol. 36 ( 2 ) page: 84 - 91   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-019-00339-w

    Web of Science

    PubMed

  4. Genetic analysis in patients with newly diagnosed glioblastomas treated with interferon-beta plus temozolomide in comparison with temozolomide alone

    Natsume Atsushi, Aoki Kosuke, Ohka Fumiharu, Maeda Sachi, Hirano Masaki, Adilijiang Alimu, Motomura Kazuya, Sumi Minako, Nishikawa Ryo, Narita Yoshitaka, Muragaki Yoshihiro, Maruyama Takashi, Ito Tamio, Beppu Takaaki, Nakamura Hideo, Kayama Takamasa, Sato Shinya, Nagane Motoo, Mishima Kazuhiko, Nakasu Yoko, Kurisu Kaoru, Yamasaki Fumiyuki, Sugiyama Kazuhiko, Onishi Takanori, Iwadate Yasuo, Terasaki Mizuhiko, Kobayashi Hiroyuki, Matsumura Akira, Ishikawa Eiichi, Sasaki Hikaru, Mukasa Akitake, Matsuo Takayuki, Hirano Hirofumi, Kumabe Toshihiro, Shinoura Nobusada, Hashimoto Naoya, Aoki Tomokazu, Asai Akio, Abe Tatsuya, Yoshino Atsuo, Arakawa Yoshiki, Asano Kenichiro, Yoshimoto Koji, Shibui Soichiro, Okuno Yusuke, Wakabayashi Toshihiko

    JOURNAL OF NEURO-ONCOLOGY   Vol. 148 ( 1 ) page: 17 - 27   2020.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11060-020-03505-9

    Web of Science

    PubMed

  5. Aberrant Transcriptional Regulation of Super-enhancers by RET Finger Protein-histone Deacetylase 1 Complex in Glioblastoma: Chemoresistance to Temozolomide

    Natsume Atsushi, Hirano Masaki, Ranjit Melissa, Aoki Kosuke, Wakabayashi Toshihiko

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 59 ( 8 ) page: 293 - 298   2019.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmc.ra.2019-0049

    Web of Science

    PubMed

  6. Comparison of the inter-laminar approach and laminotomy open approach for filum terminale lipoma: A retrospective analysis

    Nawashiro, T; Kurimoto, M; Nagakura, M; Kato, M; Aoki, K; Saito, R

    CHILDS NERVOUS SYSTEM     2024.7

     More details

  7. Pediatric-type high-grade gliomas with <i>PDGFRA</i> amplification in adult patients with Li-Fraumeni syndrome: clinical and molecular characterization of three cases

    Kibe, Y; Ohka, F; Aoki, K; Yamaguchi, J; Motomura, K; Ito, E; Takeuchi, K; Nagata, Y; Ito, S; Mizutani, N; Shiba, Y; Maeda, S; Nishikawa, T; Shimizu, H; Saito, R

    ACTA NEUROPATHOLOGICA COMMUNICATIONS   Vol. 12 ( 1 ) page: 57   2024.4

     More details

  8. Minor Suture Fusion is Associated With Chiari Malformation in Nonsyndromic Craniosynostosis

    Mizutani, K; Kurimoto, M; Nagakura, M; Nawashiro, T; Nagai, T; Aoki, K; Kato, M; Saito, R

    JOURNAL OF CRANIOFACIAL SURGERY   Vol. 34 ( 8 ) page: 2308 - 2312   2023.11

     More details

  9. IMAGING FEATURES AND CONSIDERATION OF PROGRESSION PATTERN OF DIFFUSE HEMISPHERIC GLIOMAS, H3 G34-MUTANT

    Kibe, Y; Ohka, F; Motomura, K; Aoki, K; Maeda, S; Yamaguchi, J; Shimizu, H; Saito, R

    NEURO-ONCOLOGY   Vol. 25   2023.11

     More details

  10. Predictive factors of post-operative apathy in patients with diffuse frontal gliomas undergoing awake brain mapping

    Motomura, K; Kawamura, A; Ohka, F; Aoki, K; Nishikawa, T; Yamaguchi, J; Kibe, Y; Shimizu, H; Maeda, S; Saito, R

    JOURNAL OF NEUROPSYCHOLOGY   Vol. 18 Suppl 1   page: 73 - 84   2023.9

     More details

  11. Mutation detection of urinary cell-free DNA via catch-and-release isolation on nanowires for liquid biopsy

    Takahashi, H; Yasui, T; Hirano, M; Shinjo, K; Miyazaki, Y; Shinoda, W; Hasegawa, T; Natsume, A; Kitano, Y; Ida, M; Zhang, M; Shimada, T; Paisrisarn, P; Zhu, ZT; Ohka, F; Aoki, K; Rahong, S; Nagashima, K; Yanagida, T; Baba, Y

    BIOSENSORS & BIOELECTRONICS   Vol. 234   page: 115318   2023.8

     More details

  12. Rapid detection of the <i>MYD88</i> L265P mutation for pre- and intra-operative diagnosis of primary central nervous system lymphoma

    Yamaguchi, J; Ohka, F; Kitano, Y; Maeda, S; Motomura, K; Aoki, K; Takeuchi, K; Nagata, Y; Hattori, H; Tsujiuchi, T; Motomura, A; Nishikawa, T; Kibe, Y; Shinjo, K; Kondo, Y; Saito, R

    CANCER SCIENCE   Vol. 114 ( 6 ) page: 2544 - 2551   2023.6

     More details

  13. Efficacy and safety of bevacizumab, irinotecan, and temozolomide combination for relapsed or refractory pediatric central nervous system embryonal tumor: a single-institution study

    Shiba, Y; Motomura, K; Taniguchi, R; Kurimoto, M; Mizutani, K; Ohka, F; Aoki, K; Ito, E; Nishikawa, T; Yamaguchi, J; Kibe, Y; Shimizu, H; Maeda, S; Nakashima, T; Suzuki, H; Muramatsu, H; Takahashi, Y; Saito, R

    JOURNAL OF NEUROSURGERY-PEDIATRICS   Vol. 31 ( 6 ) page: 624 - 632   2023.6

     More details

  14. Clinical characteristics and radiological features of glioblastoma, <i>IDH</i>-wildtype, grade 4 with histologically lower-grade gliomas

    Motomura, K; Kibe, Y; Ohka, F; Aoki, K; Yamaguchi, J; Saito, R

    BRAIN TUMOR PATHOLOGY   Vol. 40 ( 2 ) page: 48 - 55   2023.4

     More details

  15. Easy-to-use machine learning system for the prediction of IDH mutation and 1p/19q codeletion using MRI images of adult-type diffuse gliomas

    Nishikawa, T; Ohka, F; Aoki, K; Suzuki, H; Motomura, K; Yamaguchi, J; Maeda, S; Kibe, Y; Shimizu, H; Natsume, A; Innan, H; Saito, R

    BRAIN TUMOR PATHOLOGY   Vol. 40 ( 2 ) page: 85 - 92   2023.4

     More details

  16. <i>CD79B</i> Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma

    Yamaguchi, J; Ohka, F; Lushun, C; Motomura, K; Aoki, K; Takeuchi, K; Nagata, Y; Ito, S; Mizutani, N; Ohno, M; Suzaki, N; Takasu, S; Seki, Y; Kano, T; Wakabayashi, K; Oyama, H; Kurahashi, S; Tanahashi, K; Hirano, M; Shimizu, H; Kitano, Y; Maeda, S; Yamazaki, S; Wakabayashi, T; Kondo, Y; Natsume, A; Saito, R

    CANCER MEDICINE   Vol. 12 ( 6 ) page: 7116 - 7126   2023.3

     More details

  17. Mathematical Modeling Reveals Optimal Therapy to Prevent Malignant Transformation in Grade II IDH-Mutant Gliomas

    Haeno, H; Aoki, K; Natsume, A

    CANCER SCIENCE   Vol. 114   page: 1655 - 1655   2023.2

     More details

  18. Identification of therapeutic targets exhibiting synthetic lethality with IDH1 inhibitor using the CRISPR/Cas9 system

    Maeda, S; Aoki, K; Hinohara, K; Yamaguchi, J; Ohka, F; Natsume, A; Saito, R

    CANCER SCIENCE   Vol. 114   page: 1460 - 1460   2023.2

     More details

  19. All-in-One Nanowire Assay System for Capture and Analysis of Extracellular Vesicles from an<i> ex</i><i> Vivo</i> Brain Tumor Model

    Chattrairat, K; Yasui, T; Suzuki, S; Natsume, A; Nagashima, K; Iida, M; Zhang, M; Shimada, T; Kato, A; Aoki, K; Ohka, F; Yamazaki, S; Yanagida, T; Baba, Y

    ACS NANO   Vol. 17 ( 3 ) page: 2235 - 2244   2023.1

     More details

  20. Imaging features of localized <i>IDH</i> wild-type histologically diffuse astrocytomas: a single-institution case series

    Kibe, Y; Motomura, K; Ohka, F; Aoki, K; Shimizu, H; Yamaguchi, J; Nishikawa, T; Saito, R

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 23   2023.1

     More details

  21. ROLE OF CD79B Y196 MUTATION IN PCNSL AS A POTENT PREDICTIVE MARKER FOR FAVORABLE RESPONSE TO R-MPV TREATMENT AND DEVELOPMENT OF RAPID ALL-IN-ONE GENOTYPING SYSTEM FOR MOLECULAR MARKERS OF PCNSL

    Yamaguchi, J; Ohka, F; Lushun, C; Motomura, K; Aoki, K; Takeuchi, K; Nagata, Y; Ito, S; Mizutani, N; Ohno, M; Suzaki, N; Takasu, S; Seki, Y; Tanahashi, K; Hirano, M; Shimizu, H; Kitano, Y; Maeda, S; Yamazaki, S; Wakabayashi, T; Kondo, Y; Saito, R

    NEURO-ONCOLOGY   Vol. 24   page: 18 - 18   2022.11

     More details

  22. IDENTIFICATION OF A NOVEL THERAPEUTIC TARGET THAT IS SYNTHETICALLY LETHAL WITH MUTANT IDH INHIBITOR IN GLIOMA USING THE CRISPR/CAS9 GENOME EDITING TECHNOLOGY

    Maeda, S; Aoki, K; Hinohara, K; Yamaguchi, J; Ohka, F; Motomura, K; Kibe, Y; Natsume, A; Saito, R

    NEURO-ONCOLOGY   Vol. 24   page: 107 - 107   2022.11

     More details

  23. CLINICAL AND MOLECULAR FEATURES OF GLIOBLASTOMA, IDH-WILDTYPE ARISING IN THE SETTING OF LI FRAUMENI SYNDROME

    Kibe, Y; Ohka, F; Motomura, K; Aoki, K; Maeda, S; Yamaguchi, J; Nishikawa, T; Mizutani, K; Shimizu, H; Hiramatsu, T; Suzuki, K; Saito, R

    NEURO-ONCOLOGY   Vol. 24   page: 154 - 154   2022.11

     More details

  24. Characteristic DNA methylation profiles of chorionic villi in recurrent miscarriage

    Matsumoto, Y; Shinjo, K; Mase, S; Fukuyo, M; Aoki, K; Ozawa, F; Yoshihara, H; Goto, S; Kitaori, T; Ozaki, Y; Takahashi, S; Kaneda, A; Sugiura-Ogasawara, M; Kondo, Y

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 11673   2022.7

     More details

  25. Supratotal Resection of Gliomas With Awake Brain Mapping: Maximal Tumor Resection Preserving Motor, Language, and Neurocognitive Functions

    Motomura, K; Ohka, F; Aoki, K; Saito, R

    FRONTIERS IN NEUROLOGY   Vol. 13   page: 874826   2022.5

     More details

  26. Reliability of IDH1-R132H and ATRX and/or p53 immunohistochemistry for molecular subclassification of Grade 2/3 gliomas

    Nishikawa, T; Watanabe, R; Kitano, Y; Yamamichi, A; Motomura, K; Ohka, F; Aoki, K; Hirano, M; Kato, A; Yamaguchi, J; Maeda, S; Kibe, Y; Saito, R; Wakabayashi, T; Kato, Y; Sato, S; Ogino, T; Natsume, A; Ito, I

    BRAIN TUMOR PATHOLOGY   Vol. 39 ( 1 ) page: 14 - 24   2022.1

     More details

  27. Simple and robust methylation test for risk stratification of patients with juvenile myelomonocytic leukemia

    Kitazawa, H; Okuno, Y; Muramatsu, H; Aoki, K; Murakami, N; Wakamatsu, M; Suzuki, K; Narita, K; Kataoka, S; Ichikawa, D; Hamada, M; Taniguchi, R; Kawashima, N; Nishikawa, E; Narita, A; Nishio, N; Hama, A; Loh, ML; Stieglitz, E; Kojima, S; Takahashi, Y

    BLOOD ADVANCES   Vol. 5 ( 24 ) page: 5507 - 5518   2021.12

     More details

  28. Newly established patient-derived organoid model of intracranial meningioma

    Yamazaki, S; Ohka, F; Hirano, M; Shiraki, Y; Motomura, K; Tanahashi, K; Tsujiuchi, T; Motomura, A; Aoki, K; Shinjo, K; Murofushi, Y; Kitano, Y; Maeda, S; Kato, A; Shimizu, H; Yamaguchi, J; Adilijiang, A; Wakabayashi, T; Saito, R; Enomoto, A; Kondo, Y; Natsume, A

    NEURO-ONCOLOGY   Vol. 23 ( 11 ) page: 1936 - 1948   2021.11

     More details

  29. Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury

    Nagashima, Y; Nishimura, Y; Ohka, F; Eguchi, K; Aoki, K; Ito, H; Nishii, T; Oyama, T; Hara, M; Kitano, Y; Masaki, H; Wakabayashi, T; Natsume, A

    CELLS   Vol. 10 ( 10 )   2021.10

     More details

  30. Intraoperative seizure outcome of levetiracetam combined with perampanel therapy in patients with glioma undergoing awake brain surgery

    Motomura, K; Chalise, L; Shimizu, H; Yamaguchi, J; Nishikawa, T; Ohka, F; Aoki, K; Tanahashi, K; Hirano, M; Wakabayashi, T; Natsume, A

    JOURNAL OF NEUROSURGERY   Vol. 135 ( 4 ) page: 998 - 1007   2021.10

  31. Mathematical Modeling and Mutational Analysis Reveal Optimal Therapy to Prevent Malignant Transformation in Grade II IDH-Mutant Gliomas

    Aoki, K; Suzuki, H; Yamamoto, T; Yamamoto, KN; Maeda, S; Okuno, Y; Ranjit, M; Motomura, K; Ohka, F; Tanahashi, K; Hirano, M; Nishikawa, T; Shimizu, H; Kitano, Y; Yamaguchi, J; Yamazaki, S; Nakamura, H; Takahashi, M; Narita, Y; Nakada, M; Deguchi, S; Mizoguchi, M; Momii, Y; Muragaki, Y; Abe, T; Akimoto, J; Wakabayashi, T; Saito, R; Ogawa, S; Haeno, H; Natsume, A

    CANCER RESEARCH   Vol. 81 ( 18 ) page: 4861 - 4873   2021.9

     More details

  32. Long-term survival in patients with primary intracranial germ cell tumors treated with surgery, platinum-based chemotherapy, and radiotherapy: a single-institution study.

    Shimizu H, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Yamaguchi J, Yoshida J, Natsume A, Wakabayashi T

    Journal of neurosurgery   Vol. 135 ( 2 ) page: 449 - 457   2021.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3171/2020.6.JNS20638

    Web of Science

    PubMed

  33. Annealed ZnO/Al<sub>2</sub>O<sub>3</sub> Core-Shell Nanowire as a Platform to Capture RNA in Blood Plasma

    Takahashi, H; Yasui, T; Klamchuen, A; Khemasiri, N; Wuthikhun, T; Paisrisarn, P; Shinjo, K; Kitano, Y; Aoki, K; Natsume, A; Rahong, S; Baba, Y

    NANOMATERIALS   Vol. 11 ( 7 )   2021.7

     More details

  34. Impact of the extent of resection on the survival of patients with grade II and III gliomas using awake brain mapping

    Motomura, K; Chalise, L; Ohka, F; Aoki, K; Tanahashi, K; Hirano, M; Nishikawa, T; Yamaguchi, J; Shimizu, H; Wakabayashi, T; Saito, R

    JOURNAL OF NEURO-ONCOLOGY   Vol. 153 ( 2 ) page: 361 - 372   2021.6

     More details

  35. Urinary MicroRNA-Based Diagnostic Model for Central Nervous System Tumors Using Nanowire Scaffolds

    Kitano, Y; Aoki, K; Ohka, F; Yamazaki, S; Motomura, K; Tanahashi, K; Hirano, M; Naganawa, T; Iida, M; Shiraki, Y; Nishikawa, T; Shimizu, H; Yamaguchi, J; Maeda, S; Suzuki, H; Wakabayashi, T; Baba, Y; Yasui, T; Natsume, A

    ACS APPLIED MATERIALS & INTERFACES   Vol. 13 ( 15 ) page: 17316 - 17329   2021.4

     More details

  36. <i>Neurod4</i> converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury

    Fukuoka, T; Kato, A; Hirano, M; Ohka, F; Aoki, K; Awaya, T; Adilijiang, A; Sachi, M; Tanahashi, K; Yamaguchi, J; Motomura, K; Shimizu, H; Nagashima, Y; Ando, R; Wakabayashi, T; Lee-Liu, D; Larrain, J; Nishimura, Y; Natsume, A

    ISCIENCE   Vol. 24 ( 2 ) page: 102074   2021.2

     More details

  37. Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review.

    Yamaguchi J, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Shimizu H, Natsume A, Wakabayashi T, Saito R

    NMC case report journal   Vol. 8 ( 1 ) page: 747 - 753   2021

     More details

    Language:English  

    DOI: 10.2176/nmccrj.cr.2021-0120

    PubMed

  38. INFANTILE HEMISPHERIC BRAIN TUMOR WITH A GOPC-ROS1 FUSION GENE: A CASE REPORT

    Taniguchi, R; Natsume, A; Kawashima, N; Tanioka, S; Muramatsu, H; Hamada, M; Ichikawa, D; Imaya, M; Narita, K; Kurimoto, M; Shiba, Y; Aoki, K; Ohka, F; Hirato, J; Wakabayashi, T; Takahashi, Y

    NEURO-ONCOLOGY   Vol. 22   page: 377 - 377   2020.12

     More details

  39. Navigated repetitive transcranial magnetic stimulation as preoperative assessment in patients with brain tumors

    Motomura Kazuya, Takeuchi Hiroki, Nojima Ippei, Aoki Kosuke, Chalise Lushun, Iijima Kentaro, Wakabayashi Toshihiko, Natsume Atsushi

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 9044   2020.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-65944-8

    Web of Science

    PubMed

  40. Neurocognitive and functional outcomes in patients with diffuse frontal lower-grade gliomas undergoing intraoperative awake brain mapping

    Motomura Kazuya, Chalise Lushun, Ohka Fumiharu, Aoki Kosuke, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Yamaguchi Junya, Shimizu Hiroyuki, Wakabayashi Toshihiko, Natsume Atsushi

    JOURNAL OF NEUROSURGERY   Vol. 132 ( 6 ) page: 1683 - 1691   2020.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3171/2019.3.JNS19211

    Web of Science

    PubMed

  41. Malignant transformation of a dysembryoplastic neuroepithelial tumor verified by a shared copy number gain of the tyrosine kinase domain of FGFR1

    Matsumura Nozomi, Natsume Atsushi, Maeda Sachi, Aoki Kosuke, Yamazaki Tatsuya, Nobusawa Sumihito, Yokoo Hideaki

    BRAIN TUMOR PATHOLOGY   Vol. 37 ( 2 ) page: 69-75   2020.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-020-00361-3

    Web of Science

  42. H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant

    Maeda Sachi, Ohka Fumiharu, Okuno Yusuke, Aoki Kosuke, Motomura Kazuya, Takeuchi Kazuhito, Kusakari Hironao, Yanagisawa Nobuyuki, Sato Shinya, Yamaguchi Junya, Tanahashi Kuniaki, Hirano Masaki, Kato Akira, Shimizu Hiroyuki, Kitano Yotaro, Yamazaki Shintaro, Yamashita Shinji, Takeshima Hideo, Shinjo Keiko, Kondo Yutaka, Wakabayashi Toshihiko, Natsume Atsushi

    ACTA NEUROPATHOLOGICA COMMUNICATIONS   Vol. 8 ( 1 ) page: 8   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40478-020-0882-4

    Web of Science

    PubMed

  43. Multiple metastases to the bone and bone marrow from a 1p/19q-codeleted and <i>IDH2</i>-mutant anaplastic oligodendroglioma: a case report and literature review.

    Shimizu H, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Yamaguchi J, Wakabayashi T, Natsume A

    Neuro-oncology advances   Vol. 2 ( 1 ) page: vdaa101   2020.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/noajnl/vdaa101

    Web of Science

    PubMed

  44. AN INTEGRATED APPROACH COMBINING MATHEMATICAL AND GENOMIC METHODS TO REVEAL THE OPTIMAL TIMING OF THERAPEUTIC INTERVENTION IN WHO GRADE II DIFFUSE GLIOMA

    Aoki Kosuke, Yamamoto Takashi, Suzuki Hiromichi, Maeda Sachi, Ranjit Melissa, Motomura Kazuya, Nakamura Hideo, Narita Yoshitaka, Nakada Mitsutoshi, Deguchi Shoichi, Mizoguchi Masahiro, Momii Yasutomo, Muragaki Yoshihiro, Abe Tatsuya, Akimoto Jiro, Wakabayashi Toshihiko, Haeno Hiroshi, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 21   page: 270 - 270   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  45. MACHINE LEARNING TO DETECT GLIOMAS IN URINE-BASED LIQUID BIOPSY

    Kitano Yotaro, Aoki Kosuke, Yasui Takao, Motomura Kazuya, Ohka Fumiharu, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Shimizu Hiroyuki, Yamaguchi Junya, Maeda Sachi, Yamazaki Shintaro, Wakabayashi Toshihiko, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 21   page: 151 - 151   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  46. Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas

    Ohka Fumiharu, Shinjo Keiko, Deguchi Shoichi, Matsui Yusuke, Okuno Yusuke, Katsushima Keisuke, Suzuki Miho, Kato Akira, Ogiso Noboru, Yamamichi Akane, Aoki Kosuke, Suzuki Hiromichi, Sato Shinya, Rayan Nirmala Arul, Prabhakar Shyam, Goke Jonathan, Shimamura Teppei, Maruyama Reo, Takahashi Satoru, Suzumura Akio, Kimura Hiroshi, Wakabayashi Toshihiko, Zong Hui, Natsume Atsushi, Kondo Yutaka

    CANCER RESEARCH   Vol. 79 ( 19 ) page: 4814 - 4827   2019.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/0008-5472.CAN-19-1272

    Web of Science

    PubMed

  47. Spontaneous Tumor Regression of Intracranial Solitary Fibrous Tumor Originating From the Medulla Oblongata: A Case Report and Literature Review

    Yamaguchi Junya, Motomura Kazuya, Ohka Fumiharu, Aoki Kosuke, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Shimizu Hiroyuki, Wakabayashi Toshihiko, Natsume Atsushi

    WORLD NEUROSURGERY   Vol. 130   page: 400 - 404   2019.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2019.07.052

    Web of Science

    PubMed

  48. Next Generation Sequencing-Based Transcriptome Predicts Bevacizumab Efficacy in Combination with Temozolomide in Glioblastoma

    Adilijiang Alimu, Hirano Masaki, Okuno Yusuke, Aoki Kosuke, Ohka Fumiharu, Maeda Sachi, Tanahashi Kuniaki, Motomura Kazuya, Shimizu Hiroyuki, Yamaguchi Junya, Wakabayashi Toshihiko, Natsume Atsushi

    MOLECULES   Vol. 24 ( 17 )   2019.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/molecules24173046

    Web of Science

    PubMed

  49. Myxofibrosarcoma is characterized by frequent abnormalities in TP53 and increased genetic instability

    Takeuchi Yasuhide, Kunitz Annegret, Suzuki Hiromichi, Yoshida Kenichi, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Shimamura Teppei, Kakiuchi Nobuyuki, Shiozawa Yusuke, Yokoyama Akira, Yoshizato Tetsuichi, Aoki Kosuke, Fujii Yoichi, Nannya Yasuhito, Makishima Hideki, Miyano Satoru, Haga Hironori, Damm Frederik, Ogawa Seishi

    CANCER RESEARCH   Vol. 79 ( 13 )   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/1538-7445.AM2019-738

    Web of Science

  50. Predictive Factors Associated with Pain Relief of Spinal Cord Stimulation for Central Post-stroke Pain

    Tanei Takafumi, Kajita Yasukazu, Takebayashi Shigenori, Aoki Kosuke, Nakahara Norimoto, Wakabayashi Toshihiko

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 59 ( 6 ) page: 213 - 221   2019.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmc.oa.2018-0292

    Web of Science

    PubMed

  51. Molecular pathogenesis of disease progression in MLL-rearranged AML.

    Kotani S, Yoda A, Kon A, Kataoka K, Ochi Y, Shiozawa Y, Hirsch C, Takeda J, Ueno H, Yoshizato T, Yoshida K, Nakagawa MM, Nannya Y, Kakiuchi N, Yamauchi T, Aoki K, Shiraishi Y, Miyano S, Maeda T, Maciejewski JP, Takaori-Kondo A, Ogawa S, Makishima H

    Leukemia   Vol. 33 ( 3 ) page: 612-624   2019.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41375-018-0253-3

    PubMed

  52. Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma

    Ranjit Melissa, Hirano Masaki, Aoki Kosuke, Okuno Yusuke, Ohka Fumiharu, Yamamichi Akane, Kato Akira, Maeda Sachi, Motomura Kazuya, Matsuo Keitaro, Enomoto Atsushi, Ino Yasushi, Todo Tomoki, Takahashi Masahide, Wakabayashi Toshihiko, Kato Takuya, Natsume Atsushi

    CELL REPORTS   Vol. 26 ( 9 ) page: 2274 - +   2019.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2019.01.109

    Web of Science

    PubMed

  53. A mathematical model for predicting the optimal timing of treatment to minimize the malignant transformation rate in WHO grade II diffuse glioma

    Aoki Kousuke, Motomura Kazuya, Nakamura Hideo, Narita Yoshitaka, Yoshimoto Koji, Momii Yasutomo, Muragaki Yoshihiro, Wakabayashi Toshihiko, Haeno Hiroshi, Natsume Atsushi

    BRAIN PATHOLOGY   Vol. 29   page: 67 - 68   2019.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  54. Age-related remodelling of oesophageal epithelia by mutated cancer drivers.

    Yokoyama A, Kakiuchi N, Yoshizato T, Nannya Y, Suzuki H, Takeuchi Y, Shiozawa Y, Sato Y, Aoki K, Kim SK, Fujii Y, Yoshida K, Kataoka K, Nakagawa MM, Inoue Y, Hirano T, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Nishikawa Y, Amanuma Y, Ohashi S, Aoyama I, Horimatsu T, Miyamoto S, Tsunoda S, Sakai Y, Narahara M, Brown JB, Sato Y, Sawada G, Mimori K, Minamiguchi S, Haga H, Seno H, Miyano S, Makishima H, Muto M, Ogawa S

    Nature   Vol. 565 ( 7739 ) page: 312-317   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41586-018-0811-x

    PubMed

  55. Aberrant active-enhancers associated with downregulation of HDAC1-RFP complex overcome chemoresistance in glioblastoma

    Hirano Masaki, Melissa Ranjit, Ohka Fumiharu, Aoki Kosuke, Yamamichi Akane, Kato Takuya, Matsuo Keitaro, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

    CANCER SCIENCE   Vol. 109   page: 207 - 207   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  56. ABERRANT ACTIVE-ENHANCERS ASSOCIATED WITH DOWNREGULATION OF HDAC1-RET FINGER PROTEIN COMPLEX OVERCOME CHEMORESISTANCE IN GLIOBLASTOMA

    Hirano Masaki, Ranjit Melissa, Ohka Fumiharu, Aoki Kosuke, Yamamichi Akane, Kato Takuya, Matsuo Keitaro, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 20   page: 111 - 111   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  57. Characterization of lntraoperative Motor Evoked Potential Monitoring for Surgery of the Pediatric Population with Brain Tumors

    Motomura Kazuya, Sumita Kayo, Chalise Lushun, Nishikawa Tomohide, Tanahashi Kuniaki, Ohka Fumiharu, Aoki Kosuke, Hirano Masaki, Nakamura Tomohiko, Matsushita Tadashi, Wakabayashi Toshihiko, Natsume Atsushi

    WORLD NEUROSURGERY   Vol. 119   page: E1052 - E1059   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2018.08.039

    Web of Science

    PubMed

  58. Supratotal Resection of Diffuse Frontal Lower Grade Gliomas with Awake Brain Mapping, Preserving Motor, Language, and Neurocognitive Functions

    Motomura Kazuya, Chalise Lushun, Ohka Fumiharu, Aoki Kosuke, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Wakabayashi Toshihiko, Natsume Atsushi

    WORLD NEUROSURGERY   Vol. 119   page: 30 - 39   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2018.07.193

    Web of Science

    PubMed

  59. Validation of a novel molecular RPA classification in glioblastoma (GBM-molRPA) treated with chemoradiation: A multi-institutional collaborative study

    Wee Chan Woo, Kim Il Han, Park Chul-Kee, Kim Jin Wook, Dho Yun-Sik, Ohka Fumiharu, Aoki Kosuke, Motomura Kazuya, Natsume Atsushi, Kim Nalee, Suh Chang-Ok, Chang Jong Hee, Kim Se Hoon, Cho Won Kyung, Lim Do Hoon, Nam Do-Hyun, Choi Jung Won, Kim In Ah, Kim Chae-Yong, Oh Young-Taek, Cho Oyeon, Chung Woong-Ki, Kim Sung-Hwan, Kim Eunji

    RADIOTHERAPY AND ONCOLOGY   Vol. 129 ( 2 ) page: 347 - 351   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.radonc.2018.09.001

    Web of Science

    PubMed

  60. Long-term Effect and Predictive Factors of Motor Cortex and Spinal Cord Stimulation for Chronic Neuropathic Pain

    Tanei Takafumi, Kajita Yasukazu, Maesawa Satoshi, Nakatsubo Daisuke, Aoki Kosuke, Noda Hiroshi, Takebayashi Shigenori, Nakahara Norimoto, Wakabayashi Toshihiko

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 58 ( 10 ) page: 422 - 434   2018.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmc.oa.2018-0106

    Web of Science

    PubMed

  61. Comprehensive analysis of genetic alterations and intratumor heterogeneity in myxofibrosarcoma

    Takeuchi Yasuhide, Kunitz Annegret, Suzuki Hiromichi, Yoshida Kenichi, Kakiuchi Nobuyuki, Shiozawa Yusuke, Yokoyama Akira, Fujii Yoichi, Yoshizato Tetsuichi, Aoki Kosuke, Kataoka Keisuke, Nannya Yasuhito, Shiraishi Yuichi, Shimamura Teppei, Chiba Kenichi, Tanaka Hiroko, Makishima Hideki, Miyano Satoru, Haga Hironori, Damm Frederik, Ogawa Seishi

    CANCER RESEARCH   Vol. 78 ( 13 )   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/1538-7445.AM2018-3401

    Web of Science

  62. Pediatric-Type Follicular Lymphoma in the Dura: A Case Report and Literature Review

    Yamaguchi Junya, Kato Seiichi, Iwata Eri, Aoki Kosuke, Kabeya Ryusuke, Natsume Atsushi, Wakabayashi Toshihiko

    WORLD NEUROSURGERY   Vol. 115   page: 176 - 180   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2018.04.053

    Web of Science

    PubMed

  63. A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR

    Hirano Masaki, Ohka Fumiharu, Maeda Sachi, Chalise Lushun, Yamamichi Akane, Aoki Kosuke, Kato Akira, Tanahashi Kuniaki, Motomura Kazuya, Nishimura Yusuke, Hara Masahito, Shinjo Keiko, Kondo Yutaka, Wakabayashi Toshihiko, Natsume Atsushi

    BRAIN TUMOR PATHOLOGY   Vol. 35 ( 2 ) page: 97 - 105   2018.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-018-0310-7

    Web of Science

    PubMed

  64. Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion

    Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Kato Akira, Hirano Masaki, Motomura Kazuya, Tanahashi Kuniaki, Chalise Lushun, Maeda Sachi, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

    BRAIN TUMOR PATHOLOGY   Vol. 35 ( 2 ) page: 106 - 113   2018.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-018-0312-5

    Web of Science

    PubMed

  65. Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma.

    Kataoka K, Iwanaga M, Yasunaga JI, Nagata Y, Kitanaka A, Kameda T, Yoshimitsu M, Shiraishi Y, Sato-Otsubo A, Sanada M, Chiba K, Tanaka H, Ochi Y, Aoki K, Suzuki H, Shiozawa Y, Yoshizato T, Sato Y, Yoshida K, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Shide K, Kubuki Y, Hidaka T, Nakamaki T, Ishiyama K, Miyawaki S, Ishii R, Nureki O, Tobinai K, Miyazaki Y, Takaori-Kondo A, Shibata T, Miyano S, Ishitsuka K, Utsunomiya A, Shimoda K, Matsuoka M, Watanabe T, Ogawa S

    Blood   Vol. 131 ( 2 ) page: 215-225   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2017-01-761874

    PubMed

  66. Aberrant super-enhancers associated with downregulation of RET finger protein overcomes chemoresistance in glioblastoma

    Hirano Masaki, Ranjit Melissa, Yamamichi Akane, Aoki Kosuke, Ohka Fumiharu, Kato Takuya, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

    CANCER SCIENCE   Vol. 109   page: 461 - 461   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  67. Does ATRX immunohistochemistry deserve a surrogate of 1p/19q codel in grade II, III gliomas?

    Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Hirano Masaki, Motomura Kazuya, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

    CANCER SCIENCE   Vol. 109   page: 926 - 926   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  68. Targeting Dysregulation of EZH2-H3K27me3 as an Effective Treatment for IDH-wildtype Lower Grade Glioma

    Ohka Fumiharu, Natsume Atsushi, Suzuki Hiromichi, Aoki Kosuke, Deguchi Shoichi, Katsushima Keisuke, Shinjo Keiko, Wakabayashi Toshihiko, Kondo Yutaka

    CANCER SCIENCE   Vol. 109   page: 463 - 463   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  69. Significance of perivascular tumour cells defined by CD109 expression in progression of glioma

    Shiraki Yukihiro, Mii Shinji, Enomoto Atsushi, Momota Hiroyuki, Han Yi-Peng, Kato Takuya, Ushida Kaori, Kato Akira, Asai Naoya, Murakumo Yoshiki, Aoki Kosuke, Suzuki Hiromichi, Ohka Fumiharu, Wakabayashi Toshihiko, Todo Tomoki, Ogawa Seishi, Natsume Atsushi, Takahashi Masahide

    JOURNAL OF PATHOLOGY   Vol. 243 ( 4 ) page: 468 - 480   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/path.4981

    Web of Science

    PubMed

  70. ABERRANT SUPER-ENHANCERS ASSOCIATED WITH DOWNREGULATION OF RET FINGER PROTEIN OVERCOMES CHEMORESISTANCE IN GLIOBLASTOMA

    Hirano Masaki, Ranjit Melissa, Yamamichi Akane, Aoki Kosuke, Ohka Fumiharu, Kato Takuya, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 19   page: 103 - 103   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  71. IS ATRX IMMUNOCHEMISTRY USEFUL AS A SUBSTITUTE FOR ANALYSIS OF 1p/19q CODELETION IN GRADES II, III GLIOMAS?

    Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Hirano Masaki, Motomura Kazuya, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 19   page: 180 - 180   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  72. Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation

    Yoshizato Tetsuichi, Nannya Yasuhito, Atsuta Yoshiko, Shiozawa Yusuke, Iijima-Yamashita Yuka, Yoshida Kenichi, Shiraishi Yuichi, Suzuki Hiromichi, Nagata Yasunobu, Sato Yusuke, Kakiuchi Nobuyuki, Matsuo Keitaro, Onizuka Makoto, Kataoka Keisuke, Chiba Kenichi, Tanaka Hiroko, Ueno Hiroo, Nakagawa Masahiro M., Przychodzen Bartlomiej, Haferlach Claudia, Kern Wolfgang, Aoki Kosuke, Itonaga Hidehiro, Kanda Yoshinobu, Sekeres Mikkael A., Maciejewski Jaroslaw P., Haferlach Torsten, Miyazaki Yasushi, Horibe Keizo, Sanada Masashi, Miyano Satoru, Makishima Hideki, Ogawa Seishi

    BLOOD   Vol. 129 ( 17 ) page: 2347 - 2358   2017.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2016-12-754796

    Web of Science

    PubMed

  73. A novel all-in-one intraoperative genotyping system for IDH1-mutant glioma

    Ohka Fumiharu, Yamamichi Akane, Kurimoto Michihiro, Motomura Kazuya, Tanahashi Kuniaki, Suzuki Hiromichi, Aoki Kosuke, Deguchi Shoichi, Chalise Lushun, Hirano Masaki, Kato Akira, Nishimura Yusuke, Hara Masahito, Kato Yukinari, Wakabayashi Toshihiko, Natsume Atsushi

    BRAIN TUMOR PATHOLOGY   Vol. 34 ( 2 ) page: 91 - 97   2017.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-017-0281-0

    Web of Science

    PubMed

▼display all

Books 1

  1. がん転移学 中枢神経系の分子機構

    青木恒介、鈴木啓道、大岡史治、夏目敦至、小川誠司( Role: Contributor)

    日本臨床  2017.11 

     More details

    Language:Japanese

Presentations 1

  1. Comprehensive mutational and cytogenetic analysis revealed genetic prognostic factors in grade II and III gliomas. International conference

    Kosuke Aoki, Hiromichi Suzuki, Hideo Nakamura, Keitaro Matsuo, Kazuya Motomura, Fumiharu Ohka, Masahiro Mizoguchi, Yasutomo Momii, Yoshihiro Muragaki, Reiko Watanabe, Ichiro Ito, Toshihiko Wakabayashi, Atsushi Natsume, Seishi Ogawa

    21th ANNUAL SOCIETY FOR NEURO-ONCOLOGY SCIENTIFIC MEETING 

     More details

    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Scottsdale   Country:United States  

Research Project for Joint Research, Competitive Funding, etc. 4

  1. IDH変異神経膠腫の治療抵抗性サブクローンの解明

    2020.4 - 2021.3

    学内共同研究 

  2. IDH変異神経膠腫における治療抵抗性サブクローンの解明

    2020.4 - 2021.3

    学内共同研究 

  3. シングルセルレベルNGS解析を用いたIDH変異神経膠腫の薬物抵抗性の解明

    2020.4 - 2021.3

    学内共同研究 

  4. 高効率濃縮エクソソームを捕捉するナノワイヤ人工リンパ節を用いた脳腫瘍に対する免疫賦活

    2019.4 - 2021.3

    学内共同研究 

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. The evolutional trajection and precision-medicine to gliomas

    Grant number:20H03789  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Authorship:Coinvestigator(s) 

  2. Identification and evolutionary lineage of treatment resistance from diverse subclones in IDH mutant glioma

    2020.4 - 2022.3

    Grant-in-Aid for Scientific Research 

      More details

    Authorship:Principal investigator 

  3. IDH変異神経膠腫における多様なサブクローンからの治療抵抗性の識別と進化系統

    Grant number:20K17960  2020.4 - 2022.3

    科学研究費助成事業  若手研究

    青木 恒介

      More details

    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    低悪性度神経膠腫(LGG)は初期に緩徐な増殖を示す一方で徐々に悪性の性格を示し、しばしば致死的となる腫瘍である。LGGの8割はIDH変異が腫瘍発生に関与し、IDH変異がない症例とは遺伝学的にも臨床的にも大きく様相が異なる。IDH変異LGGに対し、化学療法や放射線治療は腫瘍縮小効果を示すが、経過中次第に抵抗性を示すようになる。本課題では、IDH変異LGGに対し一細胞毎にDNAバーコードを導入し治療前後に生存する腫瘍群を比較することで、治療抵抗性がいつ獲得されているのか、そして治療抵抗性獲得には遺伝子異常やエピゲノム変化の蓄積がどのような影響を与えるのかの解明することを目指す。
    脳腫瘍、特に低悪性度神経膠腫のゲノム異常が明らかになりつつある。神経膠腫の8割はIDH1変異が腫瘍発生に関与し、乏突起膠腫系と星細胞腫系の系譜に分かれ、特有の遺伝子変化を獲得しながら、 時間空間的に指向性を持って悪性転化・進展する。低悪性度神経膠腫に対する化学療法や放射線治療は腫瘍縮小効果を示すが、経過中次第に抵抗性を示すようになる。これらの腫瘍が腫瘍発生~診断~悪性転化~腫瘍死という時間軸のなかで、治療抵抗性をいかに獲得してくるのかは不明である。本課題では、IDH1変異神経膠腫において(1)治療抵抗性を持つサブクローンの起源と、(2)腫瘍発生~悪性転化~腫瘍死という時間軸におけるゲノムとエピゲノムの変化が、治療抵抗性にいかにかかわっているのかを明らかにすることを目指す。
    我々は、IDH1変異神経膠腫細胞株に対し、新規分子標的薬である変異IDH1阻害剤を投与した際の、細胞の増殖能や形態的変化、変異タンパク質が産生するD-2-ヒドロキシグルタル酸(D2HG)の発現量や、RNAシークエンスによる網羅的な遺伝子発現を確認した。その結果、変異IDH1阻害薬は、D2HGの発現を有意に抑制し、DNAおよびヒストンのメチル化による抑制されていた遺伝子の発現が高まる一方で、増殖能や細胞形態には変化を起こさなかった。当初の計画では、DNAバーコードライブラリを用いた治療によるサブクローン変化の追跡を予定していたが、入手可能な細胞株は阻害薬投与の有無による増殖変化を示さなかったため、サブクローン変化追跡には不向きと判断された。代わって我々は、CRISPR/Cas9を用いて遺伝子機能と治療抵抗性に関するゲノムワイドな探索を行った。その結果、変異IDH阻害薬に対する治療抵抗性を引き起こす候補遺伝子を同定し、現在in vitro実験を進めている。

  4. Novel treatment strategy targeting neoantigen induced by epigenetic alterations in malignant glioma formation

    Grant number:19KK0228  2019.10 - 2023.3

    Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

    Natsume Atsushi

      More details

    Authorship:Coinvestigator(s) 

    We have focused on a molecule named Podoplanin (PDPN) as a therapeutic target of malignant brain tumors. PDPN, a type I transmembrane mucin-like glycoprotein, is abundant in several solid tumors including squamous cell carcinoma, malignant mesothelioma, Kaposi sarcoma, angiosarcoma, testicular seminoma, and brain tumor. The expression level of PDPN is reported to be in accordance with tumor malignancy. We can relieve patients from suffering potential side effects if new measures are developed by which PDPN-expressing tumor cells are only killed.

  5. Intraoperative rapid and sensitive detection of genetic alterations in lower-grade gliomas

    Grant number:17K16643  2017.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    AOKI KOSUKE

      More details

    Authorship:Principal investigator 

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    The classification of lower-grade glioma (LGG) are based on not only pathological diagnosis, but also genetic alterations: the presence or absence of IDH mutation and 1p/19q co-deletion. Since the ATRX mutation is mutually exclusive with the 1p/19q co-deletion, it has been suggested that it could serve as a surrogate marker for genotyping of LGG. In this study, we performed immunostaining against ATRX on 78 cases of LGG with a known genetic background. Then the genetic classification was misjudged in 14% of tumors if ATRX mutation was used as a surrogate marker. We reported that ATRX mutation alone was not suitable for genotyping of LGG (Yamamichi et al, Brain Tumor Pathology, 2018). In the future, more accurate and simple genetic diagnostic methods are desired.

  6. 低悪性度悪性神経膠腫における予後不良因子の解明

    2015 - 2016

    科学研究費補助金 

      More details

    Authorship:Principal investigator 

    神経膠腫は最も高頻度に発生する脳腫瘍の一つであり、WHO gradeⅠ~Ⅳに分類される。WHO gradeⅡ・Ⅲの神経膠腫(lower grade glioma、以下LGG)は全神経膠腫の1/3を占める腫瘍であるが、今まで遺伝子異常の全貌は明らかでなかった。申請者らは757例のLGGに対し網羅的な遺伝子変異、コピー数異常の解析を行い、その全貌を世界で初めて明らかにした。それにより、LGGは発生する特徴的遺伝子異常により3つのgenetic subtypeに分かれることが分かった。これまである特定の遺伝子異常について小規模な報告はあるが、それぞれの遺伝子異常と患者予後について網羅的に解析した報告はこれまでにされていない。LGGに対する治療は未だエビデンスを持った標準治療は確立いないのが現状であり、今回それぞれのgenetic subtypeにおいて予後不良因子となる遺伝子異常を明らかにすることにより、早期治療介入が必要な群を明らかにすること、また効果的な治療法を明らかにすることを目指す。

▼display all