Organization
Graduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering Division for Advanced Medical Research Designated Assistant Professor
Title
Designated Assistant Professor
KAWAUE Takumi
Degree 1
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博士（医） （ 2016.3 名古屋大学 ）
Research History 6
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Nagoya University Graduate School of Medicine Department of Anatomy and Cell Biology Program-Specific Assistant Professor
2024.9
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Kyoto University Institute for Integrated Cell-Material Sciences, Program-Specific Assistant Professor
2021.5 - 2024.8
Country：Japan
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National University of Singapore Mechanobiology Institute
2019.5 - 2021.4
Country：Singapore
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Nagoya University Graduate School of Medicine Designated Assistant Professor
2017.4 - 2019.4
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Nagoya University Graduate School of Medicine Researcher
2016.4 - 2017.3
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Nagoya University Graduate School of Medicine
2014.4 - 2016.3
Education 1
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Nagoya University Graduate School of Medicine
2012.4 - 2016.3
Papers 16
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Featured Cover
Tanita Frey, Tomonari Murakami, Koichiro Maki, Takumi Kawaue, Naoki Tani, Ayaka Sugai, Naotaka Nakazawa, Kei‐ichiro Ishiguro, Taiji Adachi, Mineko Kengaku, Kenichi Ohki, Yukiko Gotoh, Yusuke Kishi
Aging Cell 2023.9
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Age‐associated reduction of nuclear shape dynamics in excitatory neurons of the visual cortex Reviewed
Tanita Frey, Tomonari Murakami, Koichiro Maki, Takumi Kawaue, Naoki Tani, Ayaka Sugai, Naotaka Nakazawa, Kei‐ichiro Ishiguro, Taiji Adachi, Mineko Kengaku, Kenichi Ohki, Yukiko Gotoh, Yusuke Kishi
Aging Cell 2023.7
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Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation Reviewed
Takumi Kawaue, Ivan Yow, Yuping Pan, Anh Phuong Le, Yuting Lou, Mavis Loberas, Murat Shagirov, Xiang Teng, Jacques Prost, Tetsuya Hiraiwa, Benoit Ladoux, Yusuke Toyama
Developmental Cell Vol. 58 ( 4 ) page： 267 - 277.e5 2023.2
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Interfacial friction and substrate deformation mediate long-range signal propagation in tissues Reviewed
Yuting Lou, Takumi Kawaue, Ivan Yow, Yusuke Toyama, Jacques Prost, Tetsuya Hiraiwa
Biomechanics and Modeling in Mechanobiology Vol. 21 ( 5 ) page： 1511 - 1530 2022.9
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Kawaue, T; Shitamukai, A; Nagasaka, A; Tsunekawa, Y; Shinoda, T; Saito, K; Terada, R; Bilgic, M; Miyata, T; Matsuzaki, F; Kawaguchi, A
NATURE COMMUNICATIONS Vol. 10 2019.6
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Iwata, M; Iwamoto, K; Kawano, N; Kawaue, T; Ozaki, N
PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 72 ( 10 ) page： 747 - 773 2018.10
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Pham, TQ; Kawaue, T; Hoshi, T; Tanaka, Y; Miyata, T; Sano, A
SCIENTIFIC REPORTS Vol. 8 2018.9
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Role of extrinsic mechanical force in the development of the RA-I tactile mechanoreceptor
Pham, TQ; Kawaue, T; Hoshi, T; Tanaka, Y; Miyata, T; Sano, A
SCIENTIFIC REPORTS Vol. 8 2018.7
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Watanabe, Y; Kawaue, T; Miyata, T
DEVELOPMENT Vol. 145 ( 14 ) 2018.7
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Shinoda, T; Nagasaka, A; Inoue, Y; Higuchi, R; Minami, Y; Kato, K; Suzuki, M; Kondo, T; Kawaue, T; Saito, K; Ueno, N; Fukazawa, Y; Nagayama, M; Miura, T; Adachi, T; Miyata, T
PLOS BIOLOGY Vol. 16 ( 4 ) 2018.4
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Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury
Jinnou, H; Sawada, M; Kawase, K; Kaneko, N; Herranz-Pérez, V; Miyamoto, T; Kawaue, T; Miyata, T; Tabata, Y; Akaike, T; Garcia-Verdugo, JM; Ajioka, I; Saitoh, S; Sawamoto, K
CELL STEM CELL Vol. 22 ( 1 ) page： 128 - + 2018.1
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Two-Photon Imaging of DiO-Labelled Meissner Corpuscle in Living Mouse's Fingertip Reviewed
Trung Quang Pham, Takayuki Hoshi, Yoshihiro Tanaka, Akihito Sano, Takumi Kawaue, Takaki Miyata
IEEE TRANSACTIONS ON HAPTICS Vol. 9 ( 4 ) page： 483 - 491 2016.10
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Nagasaka A, Shinoda T, Kawaue T, Suzuki M, Nagayama K, Matsumoto T, Ueno N, Kawaguchi A, Miyata T
Frontiers in cell and developmental biology Vol. 4 page： 139 2016
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Mayumi Okamoto, Tomoyasu Shinoda, Takumi Kawaue, Arata Nagasaka, Takaki Miyata
Neuroscience Research Vol. 86 page： 88 - 95 2014.9
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Takumi Kawaue, Ken Sagou, Hiroshi Kiyonari, Kumiko Ota, Mayumi Okamoto, Tomoyasu Shinoda, Ayano Kawaguchi, Takaki Miyata
DEVELOPMENT GROWTH & DIFFERENTIATION Vol. 56 ( 4 ) page： 293 - 304 2014.5
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Lhx1 in the proximal region of the optic vesicle permits neural retina development in the chicken Reviewed
Takumi Kawaue, Mayumi Okamoto, Akane Matsuyo, Junji Inoue, Yuhki Ueda, Sayuri Tomonari, Sumihare Noji, Hideyo Ohuchi
BIOLOGY OPEN Vol. 1 ( 11 ) page： 1083 - 1093 2012.11
KAKENHI (Grants-in-Aid for Scientific Research) 9
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核ラミナ構成分子の局在シフトと機械刺激がもたらすクロマチンリモデリング
Grant number：25K00115 2025.4 - 2029.3
日本学術振興会 科学研究費助成事業 基盤研究(B)
川上 巧
Authorship：Principal investigator
Grant amount：\17810000 （ Direct Cost: \13700000 、 Indirect Cost：\4110000 ）
思考や行動を司る神経回路の形成は、ニューロンの成熟プロセスを経て開始される。成熟過程において、ニューロンは数千もの遺伝子発現を段階的に変化させることが知られているが、この協調的な発現シフトがいかに達成されているかは十分に理解されていない。本研究では、ニューロン成熟前後に起こる核ラミナのダイナミックな局在シフトに着目して、核ラミナとクロマチンとの相互作用の観点から、クロマチン高次構造の動態変化がもたらす遺伝子発現の変化を調査する。さらに、ニューロン移動に伴う機械刺激に起因した核ラミナとクロマチンとの相互作用の変化と遺伝子発現の変化を調査し、ニューロンにおける核ラミナの存在意義を改めて問う。
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ニューロン成熟期の核ラミナの局在変化を介した遺伝子発現制御メカニズムの解析
2025.4 - 2026.3
堀科学芸術振興財団 研究助成
川上巧
Authorship：Principal investigator
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細胞運動に伴う核変形:神経上皮組織の細胞生産へもたらす影響
2023.4 - 2028.3
武田科学振興財団 ライフサイエンス研究助成
川上 巧
Authorship：Principal investigator
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神経上皮における細胞分裂パターンを決定する細胞動態
Grant number：23K14431 2023.4 - 2025.3
日本学術振興会 科学研究費助成事業 若手研究 若手研究
川上 巧
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細胞周期と生産される細胞種を調節する細胞動態
2023.1 - 2024.1
上原記念生命科学財団 研究奨励
川上 巧
Authorship：Principal investigator
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Grant number：18K14837 2021.3 - 2023.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Kawaue Takumi
Authorship：Principal investigator
Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）
During mammalian brain development, cell contact-mediated interactions, such as Delta-Notch signaling, are important for the cell fate choice of the newborn cells. Although the fundamental molecular mechanism of Delta-Notch signaling is well known, how Delta-presenting cells contact with the neighbors to induce their Notch activation in developing 3D tissues has been challenging to address. In this study, we demonstrated that membrane-bound Delta molecules were enriched in lamellipodia-like protrusions that were extended from the apical process of differentiating cells. In addition, the decrease in lamellipodia-like structures increased the number of differentiating cells in the cerebral cortex. These results suggest that cell-cell contacts through microstructures are involved in cell fate choice for newborn cells.
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The morphogenetic role of apoptotic force: analyses of force generation in the epithelial tissue
2019.5 - 2021.5
JSPS Overseas Research Fellowships
Authorship：Principal investigator
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神経上皮の新規運命選択機構:細胞突起の遠隔的接触によるDelta-Notch制御
2018.4 - 2021.3
文部科学省 科学研究費補助金（若手研究）
川上 巧
Authorship：Principal investigator Grant type：Competitive
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神経上皮における細胞運命決定の研究：新規三次元可視化手法による「微小環境」解析
Grant number：14J04218 2014.4 - 2016.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows
Authorship：Principal investigator
Grant amount：\1900000 （ Direct Cost: \1900000 ）