Organization
Graduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering Division for Advanced Medical Research Designated assistant professor
Title
Designated assistant professor
KAWAUE Takumi
Degree 1
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博士（医） （ 2016.3 名古屋大学 ）
Papers 7
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Kawaue, T; Shitamukai, A; Nagasaka, A; Tsunekawa, Y; Shinoda, T; Saito, K; Terada, R; Bilgic, M; Miyata, T; Matsuzaki, F; Kawaguchi, A
NATURE COMMUNICATIONS Vol. 10 2019.6
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Iwata, M; Iwamoto, K; Kawano, N; Kawaue, T; Ozaki, N
PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 72 ( 10 ) page： 747 - 773 2018.10
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Pham, TQ; Kawaue, T; Hoshi, T; Tanaka, Y; Miyata, T; Sano, A
SCIENTIFIC REPORTS Vol. 8 2018.9
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Role of extrinsic mechanical force in the development of the RA-I tactile mechanoreceptor
Pham, TQ; Kawaue, T; Hoshi, T; Tanaka, Y; Miyata, T; Sano, A
SCIENTIFIC REPORTS Vol. 8 2018.7
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Watanabe, Y; Kawaue, T; Miyata, T
DEVELOPMENT Vol. 145 ( 14 ) 2018.7
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Shinoda, T; Nagasaka, A; Inoue, Y; Higuchi, R; Minami, Y; Kato, K; Suzuki, M; Kondo, T; Kawaue, T; Saito, K; Ueno, N; Fukazawa, Y; Nagayama, M; Miura, T; Adachi, T; Miyata, T
PLOS BIOLOGY Vol. 16 ( 4 ) 2018.4
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Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury
Jinnou, H; Sawada, M; Kawase, K; Kaneko, N; Herranz-Pérez, V; Miyamoto, T; Kawaue, T; Miyata, T; Tabata, Y; Akaike, T; Garcia-Verdugo, JM; Ajioka, I; Saitoh, S; Sawamoto, K
CELL STEM CELL Vol. 22 ( 1 ) page： 128 - + 2018.1
KAKENHI (Grants-in-Aid for Scientific Research) 1
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Grant number：18K14837 2021.3 - 2023.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Kawaue Takumi
Authorship：Principal investigator
Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）
During mammalian brain development, cell contact-mediated interactions, such as Delta-Notch signaling, are important for the cell fate choice of the newborn cells. Although the fundamental molecular mechanism of Delta-Notch signaling is well known, how Delta-presenting cells contact with the neighbors to induce their Notch activation in developing 3D tissues has been challenging to address. In this study, we demonstrated that membrane-bound Delta molecules were enriched in lamellipodia-like protrusions that were extended from the apical process of differentiating cells. In addition, the decrease in lamellipodia-like structures increased the number of differentiating cells in the cerebral cortex. These results suggest that cell-cell contacts through microstructures are involved in cell fate choice for newborn cells.