Updated on 2024/03/26

写真a

 
NOMA Kentaro
 
Organization
Graduate School of Science Associate professor
Graduate School
Graduate School of Science
Undergraduate School
School of Science Department of Biological Science
Title
Associate professor
Contact information
メールアドレス
Homepage
https://nomatode.com/
External link

Degree 1

  1. PhD (Science) （ 2010.3   Kyoto University ） 

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Research Interests 4

  1. Genetics

  2. Aging

  3. C. elegans

  4. Neuroscience

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Research Areas 2

  1. Life Science / Developmental biology

  2. Life Science / Neuroscience-general

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Current Research Project and SDGs 1

  1. The mechanism of neuronal aging

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Research History 6

  1. Nagoya University   Graduate School of Science   Associate professor

    2021.7

  2. Nagoya University   Graduate School of Science Neuroscience Institute 2   Designated assistant professor

    2017.4 - 2021.6

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  3. JST Presto

    2016.9 - 2020.3

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    Country：Japan

  4. Univerisity of California, San Diego and Howard Hughes Medical Institute   Division of Biological Sciences   Postdoctoral fellow

    2012.1 - 2017.3

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    Country：United States

  5. University of California, San Diego   Division of Biological Sciences   Postdoctoral fellow

    2010.5 - 2011.12

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    Country：United States

  6. Kyoto University   Graduate School of Science, Division of Biological Sciences   Postdoctoral fellow

    2010.4 - 2017.4

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Education 2

  1. Kyoto University   Graduate School, Division of Natural Science

    - 2010.3

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    Country： Japan

  2. Kyoto University   Faculty of Science

    - 2005.3

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    Country： Japan

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Professional Memberships 4

  1. 日本神経科学学会

    2021.1

  2. Genetics Society of America

  3. 日本生物物理学会

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  4. 日本分子生物学会

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Committee Memberships 4

  1. 線虫研究の未来を創る会2023   オーガナイザー  

    2023.3   

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  2. 名古屋大学　アカデミックフラッシュ   オーガナイザー  

    2021.7   

  3. 第45回　日本分子生物学会年会   組織委員  

    2021.4 - 2023.3   

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    Committee type：Academic society

  4. 関西地区線虫勉強会   オーガナイザー  

    2021.3   

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Awards 4

  1. Best speaker award, Studium Generale

    2018   名古屋大学  

  2. Oral Presentation Award

    2016   7th Asia Pacific C. elegans meeting  

  3. DeLill Nasser Award

    2016   Genetic Society of America  

  4. Oral presentation research award at 3rd Annual UCSD Postdoctoral Research Symposium

    2015  

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Papers 13

  1. Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans.

    Suryawinata N, Yokosawa R, Tan KHC, Lai AL, Sone R, Mori I, Noma K

    Scientific reports   Vol. 14 ( 1 ) page： 5529   2024.3

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    Language：English  

    DOI： 10.1038/s41598-024-52272-4

    PubMed

  2. Diets modulate the age-dependent decline of associative learning in <i>Caenorhabditis elegans</i>

    Tanaka, M; Tsukada, S; Mohri, M; Higurashi, S; Mori, I; Noma, K

    ANNALS OF NUTRITION AND METABOLISM   Vol. 79   page： 997 - 997   2023.8

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  3. Bacterial diet affects the age-dependent decline of associative learning in Caenorhabditis elegans.

    Higurashi S, Tsukada S, Aleogho BM, Park JH, Al-Hebri Y, Tanaka M, Nakano S, Mori I, Noma K

    eLife   Vol. 12   2023.5

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    Language：English  

    DOI： 10.7554/eLife.81418

    PubMed

  4. Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans

    Zhang Albert, Noma Kentaro, Yan Dong

    G3-GENES GENOMES GENETICS   Vol. 10 ( 9 ) page： 3271 - 3278   2020.9

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  5. Designer Palmitoylation Motif-Based Self-Localizing Ligand for Sustained Control of Protein Localization in Living Cells and <i>Caenorhabditis elegans</i>

    Akinobu Nakamura, Choji Oki, Shunsuke Sawada, Tatsuyuki Yoshii, Keiko Kuwata, Andrew K. Rudd, Neal K. Devaraj, Kentaro Noma, Shinya Tsukiji

    ACS Chemical Biology   Vol. 15 ( 4 ) page： 837 - 843   2020.4

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acschembio.0c00014

    Web of Science

    PubMed

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  6. Rapid integration of multi-copy transgenes using optogenetic mutagenesis in Caenorhabditis elegans

    Kentaro Noma, Yishi Jin

    G3: Genes, Genomes, Genetics   Vol. 8 ( 6 ) page： 2091 - 2097   2018.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Genetics Society of America  

    Stably transmitted transgenes are indispensable for labeling cellular components and manipulating cellular functions. In Caenorhabditis elegans, transgenes are generally generated as inheritable multi-copy extrachromosomal arrays, which can be stabilized in the genome through a mutagenesis-mediated integration process. Standard methods to integrate extrachromosomal arrays primarily use protocols involving ultraviolet light plus trimethylpsoralen or gamma- or X-ray irradiation, which are laborious and time-consuming. Here, we describe a one-step integration method, following germline-mutagenesis induced by mini Singlet Oxygen Generator (miniSOG). Upon blue light treatment, miniSOG tagged to histone (Histone-miniSOG) generates reactive oxygen species (ROS) and induces heritable mutations, including DNA double-stranded breaks. We demonstrate that we can bypass the need to first establish extrachromosomal transgenic lines by coupling microinjection of desired plasmids with blue light illumination on Histone-miniSOG worms to obtain integrants in the F3 progeny.We consistently obtained more than one integrant from 12 injected animals in two weeks. This optogenetic approach significantly reduces the amount of time and labor for transgene integration. Moreover, it enables to generate stably expressed transgenes that cause toxicity in animal growth.

    DOI： 10.1534/g3.118.200158

    Web of Science

    Scopus

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  7. Microtubule-dependent ribosome localization in C. elegans neurons

    Kentaro Noma, Alexandr Goncharov, Mark Ellisman, Yishi Jin

    ELIFE   Vol. 6   2017.8

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELIFE SCIENCES PUBLICATIONS LTD  

    Subcellular localization of ribosomes defines the capacity for local translation. Methods to visualize ribosomes in live multicellular organisms are desirable for mechanistic investigations of the cell biology of ribosomes. Here, we developed an approach using split GFP for tissue-specific visualization of ribosomes in live Caonorhabditis elegans. Ribosomes are detected as puncta in the axons and synaptic terminals of specific neuron types, correlating with ribosome distribution at the ultrastructural level. We found that axonal ribosomes change localization during neuronal development and after axonal injury. Using genetic screens, we showed that the microtubule cytoskeleton and the JIP3 protein UNC-16 exert distinct effects on localization of axonal and somatic ribosomes. Our data demonstrate the utility of tissue-specific visualization of ribosomes in vivo, and provide insight into the mechanisms of active regulation of ribosome localization in neurons.

    DOI： 10.7554/eLife.26376

    Web of Science

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  8. Optogenetic Random Mutagenesis Using Histone-miniSOG in C. elegans.

    Noma K, Jin Y

    Journal of visualized experiments : JoVE   ( 117 )   2016.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3791/54810

    PubMed

  9. Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling

    Holland Sabrina M., Collura Kaitlin M., Ketschek Andrea, Noma Kentaro, Ferguson Toby A., Jin Yishi, Gallo Gianluca, Thomas Gareth M.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   Vol. 113 ( 3 ) page： 763-768   2016.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1073/pnas.1514123113

    Web of Science

  10. Optogenetic mutagenesis in Caenorhabditis elegans

    Noma Kentaro, Jin Yishi

    NATURE COMMUNICATIONS   Vol. 6   2015.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/ncomms9868

    Web of Science

  11. Systematic Analyses of rpm-1 Suppressors Reveal Roles for ESS-2 in mRNA Splicing in Caenorhabditis elegans

    Noma Kentaro, Goncharov Alexandr, Jin Yishi

    GENETICS   Vol. 198 ( 3 ) page： 1101-+   2014.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1534/genetics.114.167841

    Web of Science

  12. Expanding views of presynaptic terminals: new findings from Caenorhabditis elegans

    Yan Dong, Noma Kentaro, Jin Yishi

    CURRENT OPINION IN NEUROBIOLOGY   Vol. 22 ( 3 ) page： 431-437   2012.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.conb.2011.10.002

    Web of Science

  13. Triple N-Glycosylation in the Long S5-P Loop Regulates the Activation and Trafficking of the Kv12.2 Potassium Channel

    Noma Kentaro, Kimura Kazushi, Minatohara Keiichiro, Nakashima Hisako, Nagao Yasuaki, Mizoguchi Akira, Fujiyoshi Yoshinori

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 284 ( 48 ) page： 33139-33150   2009.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1074/jbc.M109.021519

    Web of Science

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Presentations 18

  1. 遺伝学的スクリーニングによる神経機能老化機構の解明

    野間 健太郎

    老化の多面的理解に向けた融合の場  2023.7.28 

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    Event date： 2023.7

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  2. Investigating the molecular mechanism of neuronal aging using forward genetic screens

    Kentaro Noma

    2023.2.22 

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    Event date： 2023.2

    Language：English   Presentation type：Poster presentation  

    Country：Japan  

  3. 食べると老いる？

    野間　健太郎

    第16 回 オープンイノベーションセミナー 「食」で共想するワークショップ  2022.12.8 

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    Event date： 2022.12

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Country：Japan  

  4. The molecular and cellular mechanisms of age-dependent behavioral decline in C. elegans Invited

    Kentaro Noma

    2022.12.2 

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    Event date： 2022.11 - 2022.12

    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    Country：Japan  

  5. Cellular and molecular mechanisms of behavioral decline in C. elegans Invited International conference

    Kentaro Noma

    Seminar at University of North Carolina  2022.10.20 

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    Event date： 2022.10

    Language：English   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：Online  

  6. Neuronal hyperactivation causes age-dependent decline in an associative learning behavior Invited International conference

    Kentaro Noma

    3rd Indian C. elegans Meeting   2022.9.30 

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    Event date： 2022.9

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Trivandrum   Country：India  

  7. Neuronal hyperactivation causes an age-dependent decline in associative learning behavior International coauthorship International conference

    Kentaro Noma

    CeNeuro2022  2022.7.26 

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    Event date： 2022.7

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Vienna   Country：Austria  

  8. １ミリの虫に問う 仕組まれた老化と死のシナリオ Invited

    野間　健太郎

    名大カフェ  2022.6.23  名古屋大学

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    Event date： 2022.6

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：オンライン   Country：Japan  

  9. Forward genetic screen to isolate mutants ameliorating age-dependent chemotaxis decline

    Kentaro Noma

    Kansai Worm Meeting  2022.3.10 

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    Event date： 2022.3

    Presentation type：Oral presentation (general)  

  10. 食べると老いる？ Invited

    野間　健太郎

    第１３回オープンイノベーションセミナー  2022.3.2  名古屋大学

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    Event date： 2022.3

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

  11. ７日齢のおばあちゃん Invited

    野間　健太郎

    第１回　アカデミックフラッシュ  2021.7.14  名古屋大学

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    Event date： 2021.7

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

  12. ７日齢のおばあちゃん Invited

    野間 健太郎

    第１回 アカデミックフラッシュ  2021.7.14  名古屋大学

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    Event date： 2021.7

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  13. Lactobacilli in a clade ameliorate age-dependent decline of thermotaxis behavior in Caenorhabditis elegans International conference

    Kentaro Noma

    23rd International C. elegans Conference  2021.6.22 

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    Event date： 2021.6

    Language：English   Presentation type：Poster presentation  

  14. Cellular and molecular mechanisms of age-dependent behavioral decline in C. elegans Invited

    Kentaro Noma

    Seminar at CRBS at Strasbourg University  2023.5.15 

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    Language：English   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  15. 加齢に伴う行動減弱の分子神経基盤 Invited

    野間 健太郎

    アドバンス生命理学特論  2023.5.26 

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    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  16. 加齢による⾏動減弱と腸の関係 Invited

    野間 健太郎

    「腸と腸外組織コミュニケーション」研究会  2023.8.31 

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    Language：Japanese  

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  17. The bucket list: 線虫に聞いておきたい老化のしくみ Invited

    野間 健太郎

    The 142nd Scienc-ome  2023.4.26 

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    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  18. Forward genetic screen to discover mutants with a less age-dependent behavioral decline in C. elegans Invited

    Kentaro Noma

    Development & Stem Cell Data Club at Strasbourg University  2023.5.12 

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    Language：English   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Research Project for Joint Research, Competitive Funding, etc. 1

  1. 遺伝学的スクリーニングによる神経機能老化機構の解明

    Grant number：1164272  2022.4

    創発的研究支援事業 

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    Authorship：Principal investigator 

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KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. 加齢による脳機能減弱を引き起こす転写産物の制御機構

    Grant number：21K06014  2021.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    野間 健太郎

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    Authorship：Principal investigator 

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    脳機能の老化は極めて普遍的かつ根源的な生命現象であるのみならず、高齢化へと突き進む現代において解決すべき喫緊の課題である。この課題に取り組むために、申請者は「どのような遺伝的プログラムが神経細胞の機能老化を制御するのか」を研究する。この目的のために本申請研究では、寿命が短く、多個体の扱いが容易で、かつ遺伝学的ツールが豊富な線虫C. elegansを用いる。そして、線虫の化学走性行動をモデルとして、老化がどのように特異的な転写産物の制御を行い、神経機能、さらには行動に影響を及ぼすのかを明らかにする。

  2. 光による革新的ゲノム改変技術の開発

    2016.9 - 2020.3

    文部科学省  戦略的創造研究推進事業 

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    Grant type：Competitive

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Industrial property rights 2

  1. 記憶・学習能維持および／または向上用組成物及び組成物を含む食品、医薬品、飼料

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    Patent/Registration no：特許第6739602号  Date issued：2020.8

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  2. 記憶・学習能維持および／または向上用組成物及び組成物を含む食品、医薬品、飼料

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    Patent/Registration no：特許第6739603号  Date issued：2020.8

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Teaching Experience (On-campus) 2

  1. Physiology and Anatomy II

    2021

  2. Physiology and Anatomy II

    2020

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Teaching Experience (Off-campus) 1

  1. 生活の中の科学

    2021.4 （Nagoya Keizai University）

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    Level：Undergraduate (liberal arts) 

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Academic Activities 1

  1. Frontiers in Physiology

    Role(s)：Peer review

    2021.5

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    Type：Peer review 

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