Updated on 2022/07/05

写真a

 
TASHIMA Yuko
 
Organization
Institute for Glyco-core Research Lecturer
Graduate School of Medicine Assistant Professor
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 2

  1. 博士(医学) ( 2006.3   大阪大学 ) 

  2. 修士(薬学) ( 2002.3   武庫川女子大学 ) 

Research Interests 2

  1. Molecular biology

  2. Glycobiology

Research Areas 2

  1. Life Science / Molecular biology

  2. Life Science / Cell biology  / Glycobiology

Current Research Project and SDGs 1

  1. 糖鎖修飾によるタンパク質の機能制御や発現制御の機構の解明

Research History 5

  1. Nagoya University   Assistant Professor

    2016.10

  2. 大阪大学微生物病研究所   免疫不全疾患研究分野   助教

    2014.4 - 2016.9

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    Country:Japan

  3. 国立循環器病研究センター研究所   分子病態部   流動研究員

    2012.4 - 2014.3

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    Country:Japan

  4. Albert Einstein College of Medicine of Yeshiva University   Dep. Cell Biology

    2007.4 - 2012.2

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    Country:United States

  5. 大阪大学微生物病研究所   免疫不全疾患研究分野   特任研究員

    2006.4 - 2007.3

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    Country:Japan

Education 2

  1. Osaka University   Graduate School, Division of Medical Sciences

    - 2006.3

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    Country: Japan

  2. Mukogawa Women's University   Faculty of Pharmaceutical Science

    - 1996.4

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    Country: Japan

Professional Memberships 3

  1. Society for Glycobiology

  2. 日本血栓止血学会

  3. The molecular biology society of Japan

Awards 1

  1. 第40回日本血栓止血学会学術集会、若手奨励賞

    2018.6   日本血栓止血学会  

    田嶌優子

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

 

Papers 19

  1. Glycoproteomics of NOTCH1 EGF repeat fragments overexpressed with different glycosyltransferases in HEK293T cells reveals insights into O-GlcNAcylation of NOTCH1.

    Tsukamoto Y, Ogawa M, Yogi K, Tashima Y, Takeuchi H, Okajima T

    Glycobiology     2022.3

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    Language:English  

    DOI: 10.1093/glycob/cwac015

    PubMed

  2. Contribution of Glucosylceramide Synthase to the Proliferation of Mouse Osteoblasts.

    Mishima Y, Hamamura K, Kato H, Furukawa K, Tashima Y, Okajima T, Kondo H, Sato T, Miyazawa K, Goto S, Togari A

    In vivo (Athens, Greece)   Vol. 35 ( 6 ) page: 3111 - 3123   2021.11

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    Language:English  

    DOI: 10.21873/invivo.12606

    PubMed

  3. Differential use of p24 family members as cargo receptors for the transport of glycosylphosphatidylinositol-anchored proteins and Wnt1.

    Tashima Y, Hirata T, Maeda Y, Murakami Y, Kinoshita T

    Journal of biochemistry     2021.10

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    Language:English  

    DOI: 10.1093/jb/mvab108

    PubMed

  4. Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers

    Barua Rashu, Mizuno Kazuyuki, Tashima Yuko, Ogawa Mitsutaka, Takeuchi Hideyuki, Taguchi Ayumu, Okajima Tetsuya

    MOLECULES   Vol. 26 ( 4 )   2021.2

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  5. 細胞外O-GlcNAcの構造と機能 Invited Reviewed

    田嶌 優子、岡島徹也

    生化学 みにれびゅう   Vol. 92 ( 6 ) page: 833 - 837   2020.12

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    Authorship:Lead author   Language:Japanese  

  6. N-glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization

    Alam Sayad Md Didarul, Tsukamoto Yohei, Ogawa Mitsutaka, Senoo Yuya, Ikeda Kazutaka, Tashima Yuko, Takeuchi Hideyuki, Okajima Tetsuya

    GLYCOBIOLOGY   Vol. 30 ( 12 ) page: 1031 - 1032   2020.12

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    Language:Japanese  

    Web of Science

  7. Glycoproteomic analysis identifies cryptdin-related sequence 1 as O-glycosylated protein modified with alpha 1,2-fucose in the small intestine

    Hashiguchi Hiroki, Tsukamoto Yohei, Ogawa Mitsutaka, Tashima Yuko, Takeuchi Hideyuki, Nakamura Masanao, Kawashima Hiroki, Fujishiro Mitsuhiro, Okajima Tetsuya

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 695   page: 108653   2020.11

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  8. N-Glycans on EGF domain-specificO-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization

    Alam Sayad Md. Didarul, Tsukamoto Yohei, Ogawa Mitsutaka, Senoo Yuya, Ikeda Kazutaka, Tashima Yuko, Takeuchi Hideyuki, Okajima Tetsuya

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 295 ( 25 ) page: 8560 - 8574   2020.6

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  9. Contribution of extracellular O-GlcNAc to the stability of folded epidermal growth factor-like domains and Notch1 trafficking

    Ogawa Mitsutaka, Tashima Yuko, Sakaguchi Yamato, Takeuchi Hideyuki, Okajima Tetsuya

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 526 ( 1 ) page: 184 - 190   2020.5

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  10. Congenital diseases caused by defective O-glycosylation of Notch receptors

    Tashima Yuko, Okajima Tetsuya

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 3 ) page: 299-307   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.80.3.299

    Web of Science

    PubMed

  11. Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions

    Tashima Yuko, Banno Fumiaki, Kita Toshiyuki, Matsuda Yasuyuki, Yanamoto Hiroji, Miyata Toshiyuki

    PLOS ONE   Vol. 12 ( 7 ) page: e0180981   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0180981

    Web of Science

    PubMed

  12. Influence of ADAMTS13 deficiency on venous thrombosis in mice Invited Reviewed

    Y.Tashima, F.Banno, M.Akiyama, T.Miyata

    Thrombosis and Haemostasis   Vol. 114 ( 1 ) page: 206 - 207   2015

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    Authorship:Lead author  

  13. Antibodies that Detect O-GlcNAc on the Extracellular Domain of Cell Surface Glycoproteins Reviewed

    Y.Tashima, P.Stanley

    The Journal of Biological Chemistry   Vol. 289 ( 16 ) page: 11132 - 11142   2014

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    Authorship:Lead author   Language:English  

  14. Galactose differentially modulates lunatic and manic Fringe effects on Delta1-induced NOTCH signaling Reviewed

    X.Hou, *Y.Tashima, P.Stanley

    The Journal of Biological Chemistry   Vol. 287 ( 1 ) page: 474 - 483   2012

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    Authorship:Lead author   Language:English  

  15. Roles of Pofut1 and O-fucose in mammalian Notch signaling Reviewed

    The Journal of Biological Chemistry   Vol. 283 ( 20 ) page: 13638 - 13651   2008

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    Language:English  

  16. Fatty acid remodeling of GPI-anchored proteins is required for their raft association Reviewed

    Y.Maeda, Y.Tashima, T.Houjou, M.Fujita, T.Yoko-O, Y.Jigami, R.Taguchi, T.Kinoshita

    Molecular Biology of the Cell   Vol. 18 ( 4 ) page: 1497 - 1506   2007

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    Language:English  

  17. PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins Reviewed

    Y.Tashima, R.Taguchi, C.Murata, H.Ashida, T.Kinoshita, Y.Maeda

    Molecular Biology of the Cell   Vol. 17 ( 3 ) page: 1410 - 1420   2006

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    Authorship:Lead author   Language:English  

  18. The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component Reviewed

    Y.Murakami, U.Siripanyaphinyo, Y.Hong, Y.Tashima, Y.Maeda, T.Kinoshita

    Molecular Biology of the Cell   Vol. 16 ( 11 ) page: 5236 - 5246   2005

  19. Inositol-deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p Reviewed

    S.Tanaka, Y.Maeda, Y.Tashima, T.Kinoshita

    The Journal of Biological Chemistry   Vol. 279 ( 14 ) page: 14256 - 14263   2004

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    Language:English  

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Books 3

  1. 新・止血血栓血管学 凝固と炎症、 2部 ショック・敗血症と凝血・炎症系

    木下タロウ、田嶌優子( Role: Sole author ,  18凝固系と補体系反応:PNHを含む)

    金芳堂  2015  ( ISBN:978-4-7653-1646-0

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    Total pages:7   Language:Japanese

  2. プリンシプル血液疾患の臨床、よくわかる血栓•止血異常の診療

    宮田敏行、田嶌優子( Role: Sole author ,  第1章 血栓止血異常症を理解するために、B 凝固反応を理解する)

    中山書店  2014.11  ( ISBN:978-4-521-73780-5

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    Total pages:10   Language:Japanese Book type:Scholarly book

  3. 実験医学別冊 タンパク質の翻訳後修飾解析プロトコール

    田嶌優子、前田祐輔( Role: Joint author ,  6章 脂質修飾の解析、5. GPIアンカー型タンパク質の解析)

    羊土社  2005.12  ( ISBN:978-4-89706-418-5

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    Total pages:7   Language:Japanese Book type:Scholarly book

KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. Significance of structural diversity of O-glucose glycans in Notch signaling

    Grant number:19KK0195  2019.10 - 2022.3

    Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

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    Authorship:Coinvestigator(s) 

  2. Identification of factor proteins in the transport of GPI-anchored proteins to the cell surface from Golgi

    Grant number:16K14696  2016.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    TASHIMA YUKO

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    Authorship:Principal investigator 

    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

    Glycosylphosphatidylinositol (GPI) tether a hydrophilic protein on the plasma membrane. Synthesis of GPI-anchored proteins (GPI-APs) in the ER and its lipid remodeling in the Golgi have been studied very well, but the transport process to the cell surface from the Golgi have not been known well. We newly established a method to monitor the transport of GPI-APs to the cell surface from the Golgi using retention using selective hooks system [Boncompain G et al., Nature methods, 2012] and HEK293 cells. To identify factor proteins for transport of GPI-APs to the cell surface from the Golgi, we used this method by introducing reporter cells with CRISPR/Cas9 and single guide RNA library. We sorted mutant cells that delayed transport of a reporter GPI to the cell surface from the Golgi. The candidate factor proteins to be related with transport of GPI-APs are analyzing by next generation sequencing.

  3. 遺伝子改変マウスを用いたプラスミノーゲン栃木変異と血栓症の検討

    2013.4 - 2015.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

 

Teaching Experience (On-campus) 4

  1. ベーシックトレーニング

    2020

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    コレステロール及びリン脂質の抽出と検出の実習を大学院生に行う。

  2. 生化学実習

    2020

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    脂質の抽出と検出の実習を3回生に行う。

  3. 生物の化学

    2020

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    エネルギー代謝について2回生に解説する。

  4. 生物学基礎I

    2020

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    生命活動に必須のエネルギーについて、1回生に解説する。