フロンティア生命化学研究会

日本農芸化学会

Investigating the applicability of the CYP102A1-decoy-molecule system to other members of the CYP102A subfamily Reviewed International coauthorship

Stanfield, JK; Onoda, H; Ariyasu, S; Kasai, C; Burfoot, EM; Sugimoto, H; Shoji, O

Journal of Inorganic Biochemistry   Vol. 245   page： 112235   2023.8

A Compound I Mimic Reveals the Transient Active Species of a Cytochrome P450 Enzyme: Insight into the Stereoselectivity of P450-Catalysed Oxidations Reviewed

Suzuki, K; Stanfield, JK; Omura, K; Shisaka, Y; Ariyasu, S; Kasai, C; Aiba, Y; Sugimoto, H; Shoji, O

Angewandte Chemie-International Edition   Vol. 62 ( 13 ) page： e202215706   2023.3

A P450 Harboring Manganese Protoporphyrin IX Generates a Manganese Analogue of Compound I by Activating Dioxygen Reviewed

Omura, K; Aiba, Y; Suzuki, K; Ariyasu, S; Sugimoto, H; Shoji, O

ACS Catalysis   Vol. 12 ( 18 ) page： 11108 - 11117   2022.9

Expanding the applicability of cytochrome P450s and other haemoproteins Invited Reviewed

Ariyasu Shinya, Stanfield Joshua Kyle, Aiba Yuichiro, Shoji Osami

Current Opinion in Chemical Biology   Vol. 59   page： 155 - 163   2020.12

Systematic Evolution of Decoy Molecules for the Highly Efficient Hydroxylation of Benzene and Small Alkanes Catalyzed by Wild-Type Cytochrome P450BM3 Reviewed

Yonemura Kai, Ariyasu Shinya, Stanfield Joshua Kyle, Suzuki Kazuto, Onoda Hiroki, Kasai Chie, Sugimoto Hiroshi, Aiba Yuichiro, Watanabe Yoshihito, Shoji Osami

ACS Catalysis   Vol. 10 ( 16 ) page： 9136 - 9144   2020.8

Molecular Design and Regulation of Metalloenzyme Activities through Two Novel Approaches: Ferritin and P450s Invited Reviewed

Watanabe Yoshihito, Aiba Yuichiro, Ariyasu Shinya, Abe Satoshi

Bulletin of the Chemical Society of Japan   Vol. 93 ( 3 ) page： 379 - 392   2020.3

Development of a High-Pressure Reactor Based on Liquid-Flow Pressurisation to Facilitate Enzymatic Hydroxylation of Gaseous Alkanes Reviewed

Ariyasu Shinya, Kodama Yusaku, Kasai Chie, Cong Zhiqi, Stanfield Joshua Kyle, Aiba Yuichiro, Watanabe Yoshihito, Shoji Osami

ChemCatChem   Vol. 11 ( 19 ) page： 4709 - 4714   2019.10

Simple and Convenient Method for the Isolation, Culture, and Recollection of Cancer Cells from Blood by Using Glass-Bead Filters Reviewed

Babita Shashni, Hidehiko Matsuura, Riku Saito, Takuma Hirata, Shinya Ariyasu, Kenta Nomura, Hiroshi Takemura, Kazunori Akimoto, Naoyuki Aikawa, Atsuo Yasumori, Shin Aoki

ACS Biomaterials Science & Engineering   Vol. 5   page： 438 - 452   2018.12

Reconstitution of full-length P450BM3 with an artificial metal complex by utilising the transpeptidase Sortase A Reviewed

Omura Keita, Aiba Yuichiro, Onoda Hiroki, Stanfield Joshua Kyle, Ariyasu Shinya, Sugimoto Hiroshi, Shiro Yoshitsugu, Shoji Osami, Watanabe Yoshihito

Chemical Communications   Vol. 54 ( 57 ) page： 7892 - 7895   2018.7

Size-based Differentiation of Cancer and Normal Cells by a Particle Size Analyzer Assisted by a Cell-recognition PC Software Reviewed

Babita Shashni, Shinya Ariyasu, Reisa Takeda, Toshihiro Suzuki, Shota Shiina, Kazunori Akimoto, Takuto Maeda, Naoyuki Aikawa, Ryo Abe, Tomohiro Osaki, Norihiko Itoh, Shin Aoki

Biological and Pharmaceutical Bulletin   Vol. 41   page： 7892 - 7895   2018.5

Reconstitution of self-sufficient cytochrome P450 with artificial metal complexes

Omura Keita, Aiba Yuichiro, Ariyasu Shinya, Shoji Osami, Sugimoto Hiroshi, Shiro Yoshitsugu, Watanabe Yoshihito

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 255   page： .   2018.3

Site-specific Dual Functionalization of Cysteine Residue in Peptides and Proteins with 2-Azidoacrylates Reviewed

Shinya Ariyasu, Hirohito Hayashi, Bengang Xing, Shunsuke Chiba

Bioconjugate Chemistry   Vol. 28   page： 897 - 902   2018.2

A chemical modulator of p53 transactivation that acts as a radioprotective agonist Reviewed

Akinori Morita, Ippei Takahashi, Megumi Sasatani, Shin Aoki, Bing Wang, Shinya Ariyasu, Kaoru Tanaka, Tetsuji Yamaguchi, Akiko Sawa, Yurie Nishi, Tatsuro Teraoka, Shohei Ujita, Yosuke Kawate, Chihiro Yanagawa, Keiji Tanimoto, Atsushi Enomoto, Mitsuru Nenoi, Kenji Kamiya, Yasushi Nagata, Yoshio Hosoi, Toshiya Inaba

Molecular Cancer Therapeutics   Vol. 17   page： 432 - 442   2017.8

Investigation of Thermally Induced Cellular Ablation and Heat Response Triggered by Planar MoS2-based Nanocomposite Reviewed

Shinya Ariyasu, Jing Mu, Xiao Zhang, Ying Huang, Edwin Kok Lee Yeow, Hua Zhang, Bengang Xing

Bioconjugate Chemistry   Vol. 28   page： 1069 - 1076   2017.2

Glycopeptide Antibiotic Analogs for Selective Inactivation and Two-Photon Imaging of Vancomycin-Resistant Strains Reviewed

Shinya Ariyasu, Pei Chui Too, Jing Mu, Chi Ching Goh, Yichen Ding, Ya Lin Tnay, Edwin Kok Lee Yeow, Liang Yang, Lai Guan Ng, Shunsuke Chiba, Bengang Xing

Chemical Communications   Vol. 52   page： 4667 - 4670   2016.2

Development of a novel sulfonate ester-based prodrug strategy Reviewed

Kengo Hanaya, Shohei Yoshioka, Shinya Ariyasu, Shin Aoki, Mitsuru Shoji, Takeshi Sugai

Bioorganic & Medicinal Chemistry Letters   Vol. 26   page： 545 - 550   2015.11

Enrichment of circulating tumor cells in tumor-bearing mouse blood by a deterministic lateral displacement microfluidic device Reviewed

Hiromasa Okano, Tomoki Konishi, Toshihiro Suzuki, Takahiro Suzuki, Shinya Ariyasu, Shin Aoki, Masanori Hayase

Biomedical Microdevices   Vol. 17   page： 1 - 11   2015.5

AS-2, a novel inhibitor of p53-dependent apoptosis, prevents apoptotic mitochondrial dysfunction in a transcription-independent manner and protects mice from a lethal dose of ionizing radiation Reviewed

Akinori Morita, Shinya Ariyasu, Bing Wang, Tetsuo Asanuma, Takayoshi Onoda, Akiko Sawa, Kaoru Tanaka, Ippei Takahashi, Shotaro Togami, Mitsuru Nenoi, Toshiya Inaba, Shin Aoki

Biochemical and Biophysical Research Communications   Vol. 450   page： 1498 - 1504   2014.7

Design and Synthesis of 8-Hydroxyquinoline-based Radioprotective Agents Reviewed

Shinya Ariyasu, Akiko Sawa, Akinori Morita, Kengo Hanaya, Misato Hoshi, Ippei Takahashi, Bing Wang and Shin Aoki

Bioorganic & Medicinal Chemistry Letters   Vol. 22   page： 3891 - 3905   2014.6

Design, Synthesis and Photochemical Reactivation of Caged Prodrugs of 8-Hydroxyquinoline-based Enzyme Inhibitors Reviewed

Shinya Ariyasu, Yuki Mizuseda, Kengo Hanaya, Shin Aoki

Chemical and Pharmaceutical Bulletin   Vol. 62   page： 642 - 648   2014.4

Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis Reviewed

Akinori Morita, Shinya Ariyasu, Soichiro Ohya, Ippei Takahashi, Bing Wang, Kaoru Tanaka, Takatoshi Uchida, Haruna Okazaki, Kengo Hanaya, Atsushi Enomoto, Mitsuru Nenoi, Masahiko Ikekita, Shin Aoki, Yoshio Hosoi

Oncotarget   Vol. 4   page： 2439 - 2450   2013.11

The Selective Capture and Collection of Live Target Cells Using a Silicon Wafer Device Modified with Antibodies via a Photocleavable Linker Reviewed

Shinya Ariyasu, Kengo Hanaya, Eita Watanabe, Toshihiro Suzuki, Kazutaka Horie, Masanori Hayase, Ryo Abe, Shin Aoki

Langmuir   Vol. 59   page： 13118 - 13126   2012.8

Photochemical Cleavage Reaction of 8-Quinolinyl Sulfonates That Are Halogenated and Nitrated at the 7-Position Reviewed

Shinya Ariyasu, Kengo Hanaya, Megumi Tsunoda, Masanori Kitamura, Masanori Hayase, Ryo Abe, Shin Aoki

Chemical and Pharmaceutical Bulletin   Vol. 59   page： 1355 - 1362   2011.8

Affinity Clusters: An Adenine-Coated Gold Cluster Binds to Thymine Loops in DNA. Reviewed

Takeshi Yamamura, Shinya Ariyasu, Ryota Sakamoto

Chemistry an Asian Journal   Vol. 6   page： 1761 - 1765   2011.4

Inorganic Bioconjugates of Gold Clusters and Nanoparticles -Briefly History and Recent Development- Invited

Takeshi Yamamura, Shinya Ariyasu

Bulletin of Japan Society of Coordination Chemistry   Vol. 55   page： 71 - 77   2010.2

Alignment of Gold Clusters on DNA via a DNA-recognizing Zinc Finger-Metallothionein Fusion Protein Reviewed

Shinya Ariyasu, Akira Onoda, Ryota Sakamoto, Takeshi Yamamura

Bioconjugate Chemistry   Vol. 20   page： 2278 - 2285   2009.9

Minimal motif peptide structure of metzincin clan zinc peptidases in micelles Reviewed

Akira Onoda, Takako Suzuki, Hiroaki Ishizuka, Shinya Ariyasu, Takeshi Yamamura

Journal of Peptide Science   Vol. 15   page： 832 - 841   2009.8

Conjugation of Au11 Cluster with Cys-rich Peptides Containing the -Domain of Metallothionein Reviewed

Shinya Ariyasu, Akira Onoda, Ryota Sakamoto, Takeshi Yamamura

Dalton Transactions   Vol. 38   page： 3742 - 3747   2009.2

Circular Dichroism of Neutral Zinc Porphyrin-Oligonucleotide Conjugates Modified with Flexible Linker Reviewed

Akira Onoda, Masahiro Igarashi, Satoshi Naganawa, Kiyomi Sasaki, Shinya Ariyasu, Takeshi Yamamura

Bulletin of the Chemical Society of Japan   Vol. 82   page： 1280 - 1286   2009.2

8-quinolinol誘導体の化学反応と酵素阻害剤・バイオケミカルツールへの応用

青木伸、有安真也、花屋賢悟、久松洋介、須貝威（ Role： Joint author）

有機合成化学協会  2016 

「気体を安全に加圧可能な高圧反応装置の開発！ ～不活性な気体資源の有効活用に道筋～」

名古屋大学-JST共同発表プレスリリース     2019.8

脂肪酸末端水酸化酵素CYP153の基質誤認識を利用した1級選択的ガス状アルカン水酸化

有安 真也、児玉 侑朔、愛場 雄一郎、荘司 長三

第31回金属の関与する生体関連反応シンポジウム  2022.6.19 

Enzymatic Methane Hydroxylation by Cytochrome P450BM3 with Chemically Evolved Decoy Molecules

Shinya Ariyasu, Kai Yonemura, Chie Kasai, Yuichiro Aiba, Hiroshi Sugimoto, Osami Shoji

2021.9.18 

シトクロムP450を用いた高圧条件下ガス状アルカンの直接水酸化

2有安真也、児玉侑朔、米村開、笠井千枝、愛場雄一郎、久保稔、當舎武彦、杉本宏、荘司長三

第47回生体分子科学討論会  2021.6.5 

Enzymatic Hydroxylation of Small Alkanes by P450BM3 with Decoy Molecules under High Pressure International conference

Shinya Ariyasu, Yusaku Kodama, Kai Yonemura, Chie Kasai, Joshua Kyle Stanfield, Yuma Shisaka, Yuichiro Aiba, Yoshihito Watanabe, Osami Shoji

The 4th IRCCS International Symposium "Multidimensional control over material structure and function”  2021.3.15 

合成分子による酵素の機能改変に基づく化学的生合成リデザイン Invited

有安　真也

新学術領域研究「生合成リデザイン」第9回公開シンポジウム  2020.11.14 

シトクロムP450による高難度ガス状アルカンの直接水酸化

有安　真也、児玉　侑朔、米村　開、笠井　千枝、愛場　雄一郎、荘司　長三

第14回バイオ関連化学シンポジウム  2020.9.8 

合成分子を用いた生体分子の機能制御と改変：シトクロムP450BM3の基質特異性変換とメタンの直接水酸化への応用 Invited

有安　真也

第180回名古屋市立大学薬学談話会  2018.10.5 

Catalytic Oxidation of Methane by Cytochrome P450BM3 Variants with Decoy Molecules International conference

Shinya Ariyasu, Zhiqi Cong, Osami Shoji, Yuichiro Aiba, Chie Kasai, Hiroki Onoda, Kazuto Suzuki, Hiroshi Sugimoto, Yoshitsugu Shiro, Takashi Kamachi, Kazunari Yoshizawa, Yoshihito Watanabe

43rd International Conference on Coordination Chemistry (ICCC2018)  2018.8.4 

Enzymatic Oxidation of Methane by Cytochrome P450BM3 Variants with Decoy Molecules under High Pressure Condition International conference

Shinya Ariyasu, Zhiqi Cong, Osami Shoji, Yuichiro Aiba, Chie Kasai, Hiroki Onoda, Kazuto Suzuki, Hiroshi Sugimoto, Yoshitsugu Shiro, Takashi Kamachi, Kazunari Yoshizawa, Yoshihito Watanabe

Cytochrome P450 Biodiversity & Biotechnology 2018  2018.7.18 

Catalytic Oxidation of Small Gaseous Alkanes by P450BM3 with Decoy Molecules International conference

Shinya Ariyasu, Zhiqi Cong, Osami Shoji, Yuichiro Aiba, Chie Kasai, Hiroki Onoda, Kazuto Suzuki, Hiroshi Sugimoto, Yoshitsugu Shiro, Takashi Kamachi, Kazunari Yoshizawa, Yoshihito Watanabe

IRCCS The 1st International Symposium  2018.1.24 

シトクロムP450 によるガス状アルカンの酸化 Invited

有安　真也

生物有機化学フォーラム2017  2017.11.11 

Divalent Glycopeptide Antibiotic Analogs for Selective Inactivation and Two-Photon Imaging of Vancomycin-Resistant Bacteria over Non-Pathogenic Escherichia coli Invited International conference

Shinya Ariyasu, Pei Chui Too, Jing Mu, Chi Ching Goh, Yichen Ding, Ya Lin Tnay, Edwin Kok Lee Yeow, Liang Yang, Lai Guan Ng, Shunsuke Chiba, Bengang Xing

4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)  2016.2.27 

Evaluation of Radioprotective Activity of Zinc-Chelator Derivatives Invited International conference

Shinya Ariyasu, Akiko Sawa, Misato Hoshi, Kengo Hanaya, Akinori Morita, Ippei Takahashi, Bing Wang, Shin Aoki

International Symposium on Technologies against Cancer (ISTC2014)  2014.3.8 

Antibody-Coated Phoreactive Microdevice for Selective Capture and Collection of Live Target Cells International conference

Shinya Ariyasu, Yuto Mukai, Eita Watanabe, Toshihiro Suzuki, Kazutaka Horie, Masanori Hayase, Ryo Abe, Shin Aoki

The 15th Asian Chemical Congress  2013.8.20 

Design and Synthesis of a Photocleavable Linker for the Isolation Device of Circulating Tumor Cells (CTCs) Invited International conference

Shinya Ariyasu, Kengo Hanaya, Eita Watanabe, Toshihiro Suzuki, Megumi Tsunoda, Misato Hoshi, Masanori Kitamura, Masanori Hayase, Ryo Abe, Shin Aoki

International Symposium on Technologies against Cancer (ISTC2011)  2011.9.2 

Location of a gold cluster at the desired position of DNA via a zinc finger-metallothionein conjugate Invited International conference

Shinya Ariyasu, Ryota Sakamoto, Takeshi Yamamura

2nd International Symposium on Bioinorganic Chemistry of the New Era  2009.8.2 

ジンクフィンガー・メタロチオネイン融合蛋白質を用いた Au クラスターの DNA 上への配列 Invited

有安　真也

錯体化学若手の会関東支部勉強会  2007.12.1 

Location of a gold cluster at the desired position of DNA via a zinc finger-metallothionein conjugate International conference

Shinya Ariyasu, Ryota Sakamoto, Takeshi Yamamura

International Union of Materials Research Societies-International Conference in Asia  2008.12 

Conjugation of Au11 Cluster with Cys-rich Peptides Containing the alpha-Domain of Metallothionein. International conference

Shinya Ariyasu, Akira Onoda, Ryota Sakamoto, Takeshi Yamamura

International Conference on Biological Inorganic Chemistry  2009.7 

Alignment of Gold Clusters on DNA via a Zinc Finger-Metallothionein Fusion Protein International conference

Shinya Ariyasu, Takeshi Yamamura, Shin Aoki

2010 International Chemical Congress of Pacific Basin Societies (PACICHEM2010)  2010.12 

The Selective Capture and Collection of Live Target Cells Using a Photoreactive Silicon Wafer Device Modified with Antibodies via Photocleavable Linkers

Shinya Ariyasu, Kengo Hanaya, Eita Watanabe, Misato Hoshi, Toshihiro Suzuki, Kazutaka Horie, Masanori Hayase, Ryo Abe, Shin Aoki

13th Tetrahedron Symposium Asia Edition  2012.11.27 

シトクロムP450によるガス状アルカンの高効率水酸化を目指した高圧反応装置の開発

有安　真也、児玉　侑朔、笠井　千枝、愛場　雄一郎、渡辺　芳人、荘司　長三

第52回酸化反応討論会  2019.11.10 

Catalytic Oxidation of Methane by Cytochrome P450BM3 Variants with Decoy Molecules

Shinya Ariyasu, Zhiqi Cong, Osami Shoji, Yuichiro Aiba, Chie Kasai, Hiroki Onoda, Kazuto Suzuki, Hiroshi Sugimoto, Yoshitsugu Shiro, Takashi Kamachi, Kazunari Yoshizawa, Yoshihito Watanabe

2018.7.30 

高圧条件下におけるP450BM3の基質誤認識を用いたガス状アルカンの水酸化

有安　真也、Zhiqi　Cong, 荘司　長三、愛場　雄一郎、笠井　千枝、児玉　侑朔、小野田　浩宜、鈴木　和人、杉本　宏、城　宜嗣、渡辺　芳人

第２８回金属の関与する生体関連反応シンポジウム  2018.6.30 

Hydroxylation of Small Gaseous Alkane by Mutated Cytochrome P450BM3 with Decoy Molecules

Shinya Ariyasu, Osami Shoji, Yuichiro Aiba, Hiroshi Sugimoto, Yoshitsugu Shiro, Yoshihito Watanabe

2018.3.20 

可視光応答性マイクロデバイスによる目的細胞の選択的捕捉と回収

有安　真也・向井　裕人、竹田　礼紗、鈴木　利宙、早瀬　仁則、安部　良、青木　伸

日本化学会第94春季年会  2014.3.27 

p53を標的とする放射線防護剤の設計と合成

有安　真也・森田　明典・高橋　一平・王　冰・澤　晶子・星　美里・内田　孝俊・大谷　聡一郎・細井　義夫・青木　伸

第7回バイオ関連化学シンポジウム  2013.9.27 

光分解可能なケミカルリンカーの設計と合成と、目的細胞の選択的捕捉、回収用デバイスへの応用

有安　真也、向井　裕人、渡邉　瑛太、鈴木　利宙、堀江　和峰、早瀬　仁則、安部　良、青木　伸

第11回次世代を担う有機化学シンポジウム  2013.5.25 

p53を標的とする放射線防護剤の探索と機構解析

有安　真也、森田　明典、高橋　一平、澤　晶子、葛岡　朋代、内田　孝俊、大谷　聡一郎、細井　義夫、青木　伸

日本化学会第93春季年会  2013.3.25 

光分解性リンカーを介した抗体修飾デバイスによる目的細胞の選択的捕捉と回収

有安　真也、花屋　賢悟、渡邉　瑛太、星　美里、鈴木　利宙、堀江　和峰、早瀬　仁則、安部　良、青木　伸

第6回バイオ関連化学シンポジウム  2012.9 

光分解性リンカーを用いた目的細胞の単離・回収用シリコンデバイスの開発

有安 真也、花屋 賢悟、星 美里、渡邉 瑛太、鈴木 利宙、早瀬 仁則、安部　良、青木 伸

日本薬学会第132年会  2012.3 

目的細胞の効率的検出・回収を目的とした光応答性抗体修飾シリコン基板の開発

有安 真也、花屋 賢悟、星 美里、渡邉 瑛太、鈴木 利宙、早瀬 仁則、安部　良、青木 伸

第5回バイオ関連化学シンポジウム  2011.9 

8-キノリノールスルホン酸エステルの光分解能向上のための官能基導入

有安　真也、花屋　賢悟、角田　めぐみ、安部　良、青木　伸

第60回有機合成化学協会関東支部シンポジウム  2011.5 

ターゲット細胞の捕捉と回収を可能とする新規光応答性シリコン基板の開発

有安　真也、花屋　賢悟、村上　明一、鈴木　利宙、渡邉　瑛太、東　隆親、安部　良、早瀬　仁則、青木　伸

日本薬学会第131年会  2011.3 

8-メルカプトアデニンを配位子とする金クラスターの合成とチミンループ含有 DNA との結合

有安 真也、角井 俊昭、坂本 良太、山村 剛士

第58回錯体化学討論会  2009.9 

DNA-ジンクフィンガー相互作用を用いた金クラスターの自由配列

有安　真也、角井　俊昭、坂本　良太、山村　剛士

日本化学会第88春季年会  2008.3 

ジンクフィンガー-メタロチオネイン-Au ナノクラスター複合体の DNA 結合能の向上

有安　真也、角井　俊昭、小野田　晃、坂本　良太、山村　剛士

第57回錯体化学討論会  2007.9 

温和な条件下での金ナノクラスターのメタロチオネインへの結合

有安　真也、角井　俊昭、小野田　晃、山村　剛士

日本化学会第87春季年会  2007.3 

ジンクフィンガーと Au ナノドット・クラスターの1:1複合体形成

有安　真也、小野田　晃、山村　剛士

第56回錯体化学討論会  2006.9 

Development of the Specific Antibodies-Coating Photoreactive Silicon Devices for Efficient Detection and Collection of Target Cell

Shinya Ariyasu, Kengo Hanaya, Misato Hoshi, Eita Watanabe, Toshihiro Suzuki, Masanori Hayase, Ryo Abe, Shin Aoki

8th AFMC International Medicinal and Chemical Symposium (AIMECS11)  2011 

Laboratory Experiments in Inorganic Chemistry

2022

Chemistry Exercises II

2021

Chemistry Exercises I

2021

Chemistry Laboratory

2021

Laboratory Experiments in Inorganic Chemistry

2021

Laboratory Experiments in Inorganic Chemistry

2020

Chemistry Laboratory

2020