2022/04/12 更新

写真a

イシカワ タクヤ
石川 卓哉
ISHIKAWA Takuya
所属
大学院医学系研究科 総合医学専攻 病態内科学 助教
大学院担当
大学院医学系研究科
学部担当
医学部 医学科
職名
助教

学位 2

  1. 医学博士 ( 2011年3月   名古屋大学 ) 

  2. 医学学士 ( 2001年3月   名古屋大学 ) 

研究分野 1

  1. ライフサイエンス / 消化器内科学  / 消化器内科学

現在の研究課題とSDGs 1

  1. 膵疾患に対する超音波内視鏡検査の診断能向上を目的とした人工知能の臨床応用

学歴 1

  1. 名古屋大学   医学系研究科   消化器内科学

    2007年4月 - 2011年3月

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    国名: 日本国

 

論文 138

  1. The modified N score is helpful for identifying patients who need endoscopic intervention among those with black stools without hematemesis.

    Ito N, Funasaka K, Fujiyoshi T, Furukawa K, Kakushima N, Furune S, Ishikawa E, Mizutani Y, Sawada T, Maeda K, Ishikawa T, Yamamura T, Ohno E, Nakamura M, Kawashima H, Miyahara R, Hirooka Y, Haruta JI, Fujishiro M

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society     2022年4月

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    記述言語:英語  

    DOI: 10.1111/den.14323

    PubMed

  2. Endoscopic management of perihilar cholangiocarcinoma.

    Kawashima H, Ohno E, Ishikawa T, Mizutani Y, Iida T, Yamamura T, Kakushima N, Furukawa K, Nakamura M

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society     2022年4月

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    記述言語:英語  

    DOI: 10.1111/den.14317

    PubMed

  3. Relationship between psoas muscle index and long-term survival in older patients aged >= 80 years after endoscopic submucosal dissection for gastric cancer

    Ito Nobuhito, Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   27 巻 ( 4 ) 頁: 729 - 738   2022年4月

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  4. Results of a Phase II Study on the use of Neoadjuvant Chemotherapy (FOLFIRINOX or Gemcitabine with nab-paclitaxel) for Borderline-Resectable Pancreatic Cancer (NUPAT-01). 査読有り

    Yamaguchi J, Yokoyama Y, Fujii T, Yamada S, Takami H, Kawashima H, Ohno E, Ishikawa T, Maeda O, Ogawa H, Kodera Y, Nagino M, Ebata T

    Annals of surgery     2022年3月

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    記述言語:英語  

    DOI: 10.1097/SLA.0000000000005430

    PubMed

  5. The impact of the age-adjusted Charlson comorbidity index as a prognostic factor for endoscopic papillectomy in ampullary tumors 査読有り

    Takada Yoshihisa, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Mizutani Yasuyuki, Iida Tadashi, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Ito Akihiro, Hirooka Yoshiki

    JOURNAL OF GASTROENTEROLOGY   57 巻 ( 3 ) 頁: 199 - 207   2022年3月

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  6. Fecal incontinence and oral regurgitation during duodenal endoscopic submucosal dissection using the water pressure method 査読有り

    Takada Yoshihisa, Hirose Takashi, Nishida Kazuki, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Fujishiro Mitsuhiro

    DIGESTIVE ENDOSCOPY   34 巻 ( 3 ) 頁: 526 - 534   2022年3月

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    記述言語:英語  

    DOI: 10.1111/den.14070

    Web of Science

    PubMed

  7. A novel scoring system to predict therapeutic intervention for non-variceal upper gastrointestinal bleeding 査読有り

    Ito Nobuhito, Funasaka Kohei, Furukawa Kazuhiro, Kakushima Naomi, Hirose Takashi, Muroi Koichi, Suzuki Tomohiko, Suzuki Takahiro, Hida Emiko, Ishikawa Takuya, Yamamura Takeshi, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Fujishiro Mitsuhiro

    INTERNAL AND EMERGENCY MEDICINE   17 巻 ( 2 ) 頁: 423 - 430   2022年3月

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  8. Artificial intelligence-based diagnosis of upper gastrointestinal subepithelial lesions on endoscopic ultrasonography images. 査読有り

    Hirai K, Kuwahara T, Furukawa K, Kakushima N, Furune S, Yamamoto H, Marukawa T, Asai H, Matsui K, Sasaki Y, Sakai D, Yamada K, Nishikawa T, Hayashi D, Obayashi T, Komiyama T, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Ishigami M, Fujishiro M

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   25 巻 ( 2 ) 頁: 382 - 391   2022年3月

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    記述言語:英語  

    DOI: 10.1007/s10120-021-01261-x

    PubMed

  9. Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma 査読有り

    Mizutani Yasuyuki, Iida Tadashi, Ohno Eizaburo, Ishikawa Takuya, Kinoshita Fumie, Kuwatsuka Yachiyo, Imai Miwa, Shimizu Shinobu, Tsuruta Toshihisa, Enomoto Atsushi, Kawashima Hiroki, Fujishiro Mitsuhiro

    BMC CANCER   22 巻 ( 1 ) 頁: 205   2022年2月

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  10. Effects of steroid use for stenosis prevention after endoscopic submucosal dissection for cervical esophageal cancer 査読有り

    Muroi Koichi, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ito Nobuhito, Hirose Takashi, Ishikawa Eri, Mizutani Yasuyuki, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Funasaka Kohei, Miyahara Ryoji, Fujishiro Mitsuhiro

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY     2022年2月

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  11. Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients 査読有り

    Nakamura Masanao, Maeda Keiko, Yamamoto Kenta, Yamamura Takeshi, Sawada Tsunaki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Iida Tadashi, Mizutani Yasuyuki, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki

    DIGESTION     頁: 1 - 12   2022年2月

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    記述言語:英語  

    DOI: 10.1159/000521929

    Web of Science

    PubMed

  12. Factors related to delayed adverse events of endoscopic submucosal dissection in the duodenum. 査読有り

    Kawamura T, Hirose T, Kakushima N, Furukawa K, Furune S, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Honda T, Ishigami M, Kawashima H, Fujishiro M

    Digestive diseases (Basel, Switzerland)     2022年2月

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    記述言語:英語  

    DOI: 10.1159/000522362

    PubMed

  13. Initial experience of tofacitinib for treating refractory moderate-to-severe ulcerative colitis 査読有り

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 1 ) 頁: 169 - 179   2022年2月

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  14. Development of a Novel Evaluation Method for Endoscopic Ultrasound-Guided Fine-Needle Biopsy in Pancreatic Diseases Using Artificial Intelligence 査読有り

    Ishikawa Takuya, Hayakawa Masato, Suzuki Hirotaka, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Fujishiro Mitsuhiro, Kawashima Hiroki, Hotta Kazuhiro

    DIAGNOSTICS   12 巻 ( 2 )   2022年2月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.3390/diagnostics12020434

    Web of Science

    PubMed

  15. Usefulness of Macroscopic On-Site Evaluation Using a Stereomicroscope during EUS-FNB for Diagnosing Solid Pancreatic Lesions 査読有り

    Ishikawa Takuya, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Uetsuki Kota, Yashika Jun, Yamada Kenta, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Takada Yoshihisa, Takahashi Hidekazu, Aoi Hironori, Kato Katsuyuki, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao, Hirooka Yoshiki, Kawashima Hiroki

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2022 巻   頁: 2737578   2022年1月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.1155/2022/2737578

    Web of Science

    PubMed

  16. Comparison of outcomes between secondary fully covered and uncovered self-expandable metal stents in the treatment of recurrent biliary obstruction of pancreatic cancer 査読有り

    Kataoka Kunio, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Mizutani Yasuyuki, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES     2022年1月

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  17. Fish bone migration after pancreaticoduodenectomy: Incidence and treatment options 査読有り

    Takada Yoshihisa, Ishikawa Takuya, Kawashima Hiroki, Mizutani Yasuyuki, Ohno Eisaburo, Iida Tadashi, Ogawa Hiroshi, Hayashi Masamichi, Takami Hideki, Onoe Shunsuke, Ishigami Masatoshi

    JOURNAL OF DIGESTIVE DISEASES   23 巻 ( 1 ) 頁: 44 - 49   2022年1月

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  18. Current status of the diagnosis of chronic pancreatitis by ultrasonographic elastography 査読有り

    Nakaoka Kazunori, Hashimoto Senju, Miyahara Ryoji, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kuwahara Takamichi, Tanaka Hiroyuki, Hirooka Yoshiki

    KOREAN JOURNAL OF INTERNAL MEDICINE   37 巻 ( 1 ) 頁: 27 - 36   2022年1月

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  19. Differentiation Between Solid Pseudopapillary Neoplasm of the Pancreas and Nonfunctional Pancreatic Neuroendocrine Neoplasm Using Endoscopic Ultrasound 査読有り

    Kataoka Kunio, Ishikawa Takuya, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    PANCREAS   51 巻 ( 1 ) 頁: 106 - 111   2022年1月

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  20. Evaluation of ulcerative colitis activity using transabdominal ultrasound shear wave elastography 査読有り

    Yamada Kenta, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Iida Tadashi, Ishikawa Eri, Mizutani Yasuyuki, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao, Ishigami Masatoshi, Fujishiro Mitsuhiro

    QUANTITATIVE IMAGING IN MEDICINE AND SURGERY   12 巻 ( 1 ) 頁: 618 - 626   2022年1月

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  21. Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching 査読有り

    Saito Masashi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Mizutani Yasuyuki, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   27 巻 ( 47 ) 頁: 8182 - 8193   2021年12月

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  22. Comparison of contrast-enhanced transabdominal ultrasonography following endoscopic ultrasonography with GD-EOB-DTPA-enhanced MRI for the sequential diagnosis of liver metastasis in patients with pancreatic cancer 査読有り

    Ishikawa Takuya, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Koya Toshinari, Sasaki Yutaka, Ogawa Hiroshi, Kinoshita Fumie, Hirooka Yoshiki, Kawashima Hiroki

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES     2021年12月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.1002/jhbp.1097

    Web of Science

    PubMed

  23. Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival 査読有り

    Yamada Kentaro, Sawada Tsunaki, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Ishikawa Eri, Iida Tadashi, Mizutani Yasuyuki, Kakushima Naomi, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Furune Satoshi, Hase Tetsunari, Yokota Kenji, Maeda Osamu, Hashimoto Naozumi, Akiyama Masashi, Ando Yuichi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   27 巻 ( 41 ) 頁: 7190 - 7206   2021年11月

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  24. Gastrointestinal: Pancreatic metastasis from extramammary Paget's disease diagnosed by endoscopic ultrasound-guided fine-needle biopsy 査読有り

    Suzuki H., Ishikawa T., Ohno E., Kawashima H., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   36 巻 ( 11 ) 頁: 3000 - 3000   2021年11月

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    記述言語:英語  

    DOI: 10.1111/jgh.15444

    Web of Science

  25. Endocytoscopy Is Useful for the Diagnosis of Superficial Nonampullary Duodenal Epithelial Tumors 査読有り

    Hirose Takashi, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Nishida Kazuki, Yokoi Takio, Kawashima Hiroki, Fujishiro Mitsuhiro

    DIGESTION   102 巻 ( 6 ) 頁: 895 - 902   2021年11月

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    記述言語:英語  

    DOI: 10.1159/000516512

    Web of Science

    PubMed

  26. Imaging diagnosis of autoimmune pancreatitis using endoscopic ultrasonography 査読有り

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Mizutani Yasuyuki, Fujishiro Mitsuhiro

    JOURNAL OF MEDICAL ULTRASONICS   48 巻 ( 4 ) 頁: 543 - 553   2021年10月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.1007/s10396-021-01143-w

    Web of Science

    PubMed

  27. Differentiation between pancreatic metastases from renal cell carcinoma and pancreatic neuroendocrine neoplasm using endoscopic ultrasound 査読有り

    Kataoka Kunio, Ishikawa Takuya, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Ishikawa Eri, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    PANCREATOLOGY   21 巻 ( 7 ) 頁: 1364 - 1370   2021年10月

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  28. An Unusual Pancreatic Mass with Ductal Disruption: Benign or Malignant? Type 2 Autoimmune Pancreatitis 査読有り

    Takada Yoshihisa, Ishikawa Takuya, Kawashima Hiroki

    GASTROENTEROLOGY   161 巻 ( 4 ) 頁: 1113 - 1115   2021年10月

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  29. Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms 査読有り

    Esaki Masaya, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Suzuki Hiroto, Kuno Takeshi, Yamada Kentaro, Hasegawa Issei, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    DIGESTION   102 巻 ( 5 ) 頁: 701 - 713   2021年9月

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    記述言語:英語  

    DOI: 10.1159/000511589

    Web of Science

    PubMed

  30. A forward-viewing radial-array echoendoscope is useful for diagnosing the depth of colorectal neoplasia invasion 査読有り

    Kuno Takeshi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Esaki Masaya, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   35 巻 ( 8 ) 頁: 4389 - 4398   2021年8月

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  31. Feasibility of patency capsule and colon capsule endoscopy in patients with suspected gastrointestinal stenosis: a prospective study 査読有り

    Otsuka Hiroyuki, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawade Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Iliroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    NAGOYA JOURNAL OF MEDICAL SCIENCE   83 巻 ( 3 ) 頁: 419 - 430   2021年8月

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  32. Detection of Colorectal Neoplasms Using Linked Color Imaging: A Prospective, Randomized, Tandem Colonoscon Trial 査読有り

    Hasegawa Issei, Yamamura Takeshi, Suzuki Hiroto, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Nakamura Masanao, Fujishiro Mitsuhiro

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   19 巻 ( 8 ) 頁: 1708 - +   2021年8月

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  33. Double common bile duct associated with pancreaticobiliary maljunction 査読有り

    Yamada Kenta, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yoshikawa Masakatsu, Takami Hideki, Inokawa Yoshikuni, Uchida Hiroo, Kawashima Hiroki, Fujishiro Mitsuhiro

    NAGOYA JOURNAL OF MEDICAL SCIENCE   83 巻 ( 3 ) 頁: 655 - 661   2021年8月

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  34. Lewis score on capsule endoscopy can predict the prognosis in patients with small bowel lesions of Crohn's disease 査読有り

    Nishikawa Takahiro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   36 巻 ( 7 ) 頁: 1851 - 1858   2021年7月

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    記述言語:英語  

    DOI: 10.1111/jgh.15366

    Web of Science

    PubMed

  35. Subjective Symptoms in Patients with Eosinophilic Esophagitis Are Related to Esophageal Wall Thickness and Esophageal Body Pressure 査読有り

    Muroi Koichi, Kakushima Naomi, Furukawa Kazuhiro, Ishikawa Eri, Sawada Tsunaki, Ishikawa Takuya, Maeda Keiko, Yamamura Takeshi, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Funasaka Kohei, Miyahara Ryoji, Fujishiro Mitsuhiro

    DIGESTIVE DISEASES AND SCIENCES   66 巻 ( 7 ) 頁: 2291 - 2300   2021年7月

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  36. Endoscopic papillectomy for ampullary adenoma and early adenocarcinoma: Analysis of factors related to treatment outcome and long-term prognosis 査読有り

    Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Tanaka Hiroyuki, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Hashimoto Senju, Itoh Akihiro, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    DIGESTIVE ENDOSCOPY   33 巻 ( 5 ) 頁: 858 - 869   2021年7月

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    記述言語:英語  

    DOI: 10.1111/den.13881

    Web of Science

    PubMed

  37. Long-Term Prognostic Predictors of Esophageal Squamous Cell Carcinoma Potentially Indicated for Endoscopic Submucosal Dissection 査読有り

    Suzuki Tomohiko, Furukawa Kazuhiro, Funasaka Kohei, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Fujishiro Mitsuhiro

    DIGESTION   102 巻 ( 4 ) 頁: 563 - 571   2021年6月

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    記述言語:英語  

    DOI: 10.1159/000510091

    Web of Science

    PubMed

  38. An evaluation of resectability among endoscopic treatment methods for rectal neuroendocrine tumors < 10 mm 査読有り

    Toriyama Kazuhiro, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Furukawa Kazuhiro, Ishikawa Takuya, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro

    ARAB JOURNAL OF GASTROENTEROLOGY   22 巻 ( 2 ) 頁: 104 - 110   2021年6月

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  39. Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus 査読有り

    Muroi Koichi, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Onoue Takeshi, Arima Hiroshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    DIGESTION   102 巻 ( 4 ) 頁: 554 - 562   2021年6月

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    記述言語:英語  

    DOI: 10.1159/000510081

    Web of Science

    PubMed

  40. Endosonography-guided transmural drainage of pancreatic fluid collections: comparative outcomes by stent type 査読有り

    Kayal Ahmed, Taghizadeh Niloofar, Ishikawa Takuya, Gonzalez-Moreno Emmanuel, Bass Sydney, Cole Martin J., Heitman Steven J., Mohamed Rachid, Turbide Christian, Chen Yen- I, Forbes Nauzer

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   35 巻 ( 6 ) 頁: 2698 - 2708   2021年6月

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  41. An initial trial of quantitative evaluation of autoimmune pancreatitis using shear wave elastography and shear wave dispersion in transabdominal ultrasound 査読有り

    Suzuki Hirotaka, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Fujishiro Mitsuhiro

    PANCREATOLOGY   21 巻 ( 4 ) 頁: 682 - 687   2021年6月

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  42. Immunohistochemical staining for IMP3 in patients with duodenal papilla tumors: assessment of the potential for diagnosing endoscopic resectability and predicting prognosis 招待有り 査読有り

    Tanaka Hiroyuki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Ishikawa Eri, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Shimoyama Yoshie, Miyahara Ryoji, Kawabe Naoto, Kuzuya Teiji, Hashimoto Senju, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   21 巻 ( 1 ) 頁: 224   2021年5月

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  43. Measurement of fasting breath hydrogen concentration as a simple diagnostic method for pancreatic exocrine insufficiency 査読有り

    Uetsuki Kota, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Yamamoto Kenta, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   21 巻 ( 1 ) 頁: 211   2021年5月

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  44. Diagnostic performance of endoscopic ultrasonography-guided elastography for solid pancreatic lesions: Shear-wave measurements versus strain elastography with histogram analysis 査読有り

    Ohno Eizaburo, Kawashima Hiroki, Ishikawa Takuya, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Hirooka Yoshiki, Fujishiro Mitsuhiro

    DIGESTIVE ENDOSCOPY   33 巻 ( 4 ) 頁: 629 - 638   2021年5月

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    記述言語:英語  

    DOI: 10.1111/den.13791

    Web of Science

    PubMed

  45. Endoscopic removal of a fish bone piercing the bile duct after pancreaticoduodenectomy 査読有り

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Nakamura Masanao, Yamada Suguru, Hayashi Masamichi, Fujishiro Mitsuhiro

    ENDOSCOPY   53 巻 ( 05 ) 頁: E164 - E165   2021年5月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.1055/a-1224-3724

    Web of Science

    PubMed

  46. Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy 査読有り

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2021 巻   頁: 8875564   2021年4月

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  47. Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer 査読有り

    Yoshikawa Masakatsu, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kinoshita Fumie, Kawashima Hiroki, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   11 巻 ( 1 ) 頁: 7409   2021年4月

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  48. Filtrated Adipose Tissue-Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice 査読有り

    Nishikawa Takahiro, Maeda Keiko, Nakamura Masanao, Yamamura Takeshi, Sawada Tsunaki, Mizutani Yasuyuki, Ito Takanori, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Yamamoto Tokunori, Matsumoto Seiji, Hotta Yuji, Fujishiro Mitsuhiro

    DIGESTIVE DISEASES AND SCIENCES   66 巻 ( 4 ) 頁: 1034 - 1044   2021年4月

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  49. Utility of multiphase contrast enhancement patterns on CEH-EUS for the differential diagnosis of IPMN-derived and conventional pancreatic cancer

    Yashika Jun, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Shimoyama Yoshie, Ishikawa Eri, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Hirooka Yoshiki, Kawashima Hiroki, Fujishiro Mitsuhiro

    PANCREATOLOGY   21 巻 ( 2 ) 頁: 390 - 396   2021年3月

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  50. Endoscopic ultrasound elastography for small solid pancreatic lesions with or without main pancreatic duct dilatation

    Kataoka Kunio, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    PANCREATOLOGY   21 巻 ( 2 ) 頁: 451 - 458   2021年3月

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  51. Diagnostic yield of colon capsule endoscopy for Crohn's disease lesions in the whole gastrointestinal tract

    Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   21 巻 ( 1 ) 頁: 75   2021年2月

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  52. Clinical characteristics and long-term prognosis of autoimmune pancreatitis with renal lesions

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Hirooka Yoshiki, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   11 巻 ( 1 ) 頁: 406   2021年1月

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  53. Risks and characteristics of pancreatic cancer and pancreatic relapse in autoimmune pancreatitis patients

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yamada Kenta, Yashika Jun, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   35 巻 ( 12 ) 頁: 2281 - 2288   2020年12月

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    記述言語:日本語  

    DOI: 10.1111/jgh.15163

    Web of Science

    PubMed

  54. The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease

    Hattori Shun, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Yamamoto Kenta, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY   55 巻 ( 12 ) 頁: 1138 - 1149   2020年12月

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  55. Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy

    Niwa Yoshiki, Nakamura Masanao, Kawashima Hiroki, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   26 巻 ( 42 ) 頁: 6669 - 6678   2020年11月

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  56. Mutation analysis of gastrointestinal stromal tumors using RNA obtained via endoscopic ultrasound-guided fine-needle aspiration

    Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Hirooka Yoshiki, Ohmiya Naoki, Fujishiro Mitsuhiro

    TRANSLATIONAL ONCOLOGY   13 巻 ( 11 ) 頁: 100848   2020年11月

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  57. Endoscopic Activity and Serum TNF-alpha Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn's Disease Patients

    Murate Kentaro, Maeda Keiko, Nakamura Masanao, Sugiyama Daisuke, Wada Hirotaka, Yamamura Takeshi, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Miyahara Ryoji, Ishigami Masatoshi, Nishikawa Hiroyoshi, Fujishiro Mitsuhiro

    INFLAMMATORY BOWEL DISEASES   26 巻 ( 11 ) 頁: 1669 - 1681   2020年11月

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  58. Usefulness of endoscopic ultrasound-guided fine-needle biopsy for the diagnosis of autoimmune pancreatitis using a 22-gauge Franseen needle: a prospective multicenter study.

    Ishikawa T, Kawashima H, Ohno E, Suhara H, Hayashi D, Hiramatsu T, Matsubara H, Suzuki T, Kuwahara T, Ishikawa E, Shimoyama Y, Kinoshita F, Hirooka Y, Fujishiro M

    Endoscopy   52 巻 ( 11 ) 頁: 978 - 985   2020年11月

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    記述言語:英語  

    DOI: 10.1055/a-1183-3583

    PubMed

  59. AMINO ACID POLYMORPHISM IN HEPATITIS B VIRUS ASSOCIATED WITH NATURAL CLEARANCE OF HBV DNA AND HBsAg

    Honda Takashi, Yamada None, Murayama Asako, Kato Asuka, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Ishigami Masatoshi, Murakami Yoshiki, Ishikawa Tetsuya, Fujishiro Mitsuhiro, Kato Takanobu

    HEPATOLOGY   72 巻   頁: 508A - 509A   2020年11月

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    記述言語:日本語  

    Web of Science

  60. What is the role of measuring shear wave dispersion using shear wave elastography in pancreatic parenchyma?

    Suzuki Hirotaka, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Hashimoto Senju, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    JOURNAL OF MEDICAL ULTRASONICS   47 巻 ( 4 ) 頁: 575 - 581   2020年10月

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  61. Can contrast-enhanced harmonic endoscopic ultrasonography accurately diagnose main pancreatic duct involvement in intraductal papillary mucinous neoplasms?

    Ohno Eizaburo, Kawashima Hiroki, Ishikawa Takuya, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    PANCREATOLOGY   20 巻 ( 5 ) 頁: 887 - 894   2020年7月

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  62. Gender difference in the transabdominal ultrasound findings of solid-pseudopapillary neoplasm

    Sasaki Yutaka, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Shimoyama Yoshie, Ishikawa Eri, Fujishiro Mitsuhiro

    PANCREATOLOGY   20 巻 ( 5 ) 頁: 997 - 1003   2020年7月

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  63. Giant fibrovascular polyp of the esophagus with intermittent airway obstruction

    Ishikawa Takuya, Bishay Kirles, Belletrutti Paul J., Gui Xianyong, Forbes Nauzer

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY   32 巻 ( 7 ) 頁: 895 - 896   2020年7月

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  64. Endoscopic ultrasonography for the evaluation of pancreatic cystic neoplasms

    Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Fujishiro Mitsuhiro

    JOURNAL OF MEDICAL ULTRASONICS   47 巻 ( 3 ) 頁: 401 - 411   2020年7月

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  65. Use of Immunostaining for the diagnosis of Lymphovascular invasion in superficial Barrett's esophageal adenocarcinoma

    Hosono Isao, Miyahara Ryoji, Furukawa Kazuhiro, Funasaka Kohei, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Yokoi Takio, Hirooka Yoshiki, Fujishiro Mitsuhiro, Tsukamoto Tetsuya

    BMC GASTROENTEROLOGY   20 巻 ( 1 ) 頁: 175   2020年6月

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  66. ENDOSCOPIC DIAGNOSIS USING MAGNIFYING IMAGE-ENHANCED ENDOSCOPY FOR SUPERFICIAL NON-AMPULLARY DUODENAL EPITHELIAL TUMORS

    Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Sawada Tsunaki, Keiko Maeda, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB618 - AB618   2020年6月

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    記述言語:日本語  

    Web of Science

  67. EVALUATION OF RESECTABILITY BETWEEN ENDOSCOPIC TREATMENT METHODS FOR RECTAL NEUROENDOCRINE TUMOR

    Toriyama Kazuhiro, Yamamura Takeshi, Nakamura Masanao, Keiko Maeda, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB101 - AB101   2020年6月

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    記述言語:日本語  

    Web of Science

  68. NOVEL METHOD TO DETERMINE THE DEPTH OF INVASION IN COLORECTAL NEOPLASMS WITH ULTRASOUND ELASTOGRAPHY USING A FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE

    Esaki Masaya, Yamamura Takeshi, Nakamura Masanao, Keiko Maeda, Sawada Tsunaki, Mizutani Yasuyuki, Kuno Takeshi, Yamada Kentaro, Hasegawa Issei, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB430 - AB430   2020年6月

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    記述言語:日本語  

    Web of Science

  69. PROSPECTIVE MULTICENTER STUDY ON THE USEFULNESS OF EUS-GUIDED FINE NEEDLE BIOPSY FOR THE DIAGNOSIS OF AUTOIMMUNE PANCREATITIS USING A 22-GAUGE FRANSEEN NEEDLE

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yamada Kenta, Yashika Jun, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Keiko Maeda, Sawada Tsunaki, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB172 - AB172   2020年6月

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    記述言語:日本語  

    Web of Science

  70. Clinical Factors Associated with Missing Colorectal Polyp on Colon Capsule Endoscopy

    Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hotta Naoki, Hirooka Yoshiki

    DIGESTION   101 巻 ( 3 ) 頁: 316 - 322   2020年5月

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    記述言語:日本語  

    DOI: 10.1159/000498942

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    PubMed

  71. Diagnosis of vascular invasion in pancreatic ductal adenocarcinoma using endoscopic ultrasound elastography

    Yamada Kenta, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Tanaka Hiroyuki, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   20 巻 ( 1 ) 頁: 81   2020年3月

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  72. Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study

    Nishio Ryo, Kawashima Hiroki, Nakamura Masanao, Ohno Eizaburo, Ishikawa Takuya, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Tanaka Hiroyuki, Sakai Daisuke, Miyahara Ryoji, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   26 巻 ( 10 ) 頁: 1056 - 1066   2020年3月

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  73. Usefulness of Endoscopic Ultrasound Elastography Combined With the Strain Ratio in the Estimation of Treatment Effect in Autoimmune Pancreatitis

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Tanaka Hiroyuki, Maeda Keiko, Sawada Tsunaki, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Fujishiro Mitsuhiro

    PANCREAS   49 巻 ( 2 ) 頁: E21 - E22   2020年2月

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  74. Color information from linked color imaging is associated with invasion depth and vascular diameter in superficial esophageal squamous cell carcinoma

    Kobayashi Kenichi, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Nakaguro Masato, Okumura Yuki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    DIGESTIVE ENDOSCOPY   32 巻 ( 1 ) 頁: 65 - 73   2020年1月

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    記述言語:日本語  

    DOI: 10.1111/den.13469

    Web of Science

    PubMed

  75. Generation of magnifying endoscopic images of gastric neoplasms based on an all-in-focus algorithm

    Matsui Kenichi, Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Ohara Kenichi, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   35 巻 ( 1 ) 頁: 65 - 70   2020年1月

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    記述言語:日本語  

    DOI: 10.1111/jgh.14792

    Web of Science

    PubMed

  76. A Prospective Study of Factors Associated with Abdominal Pain in Patients during Unsedated Colonoscopy Using a Magnifying Endoscope

    Suzuki Hiroto, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    INTERNAL MEDICINE   59 巻 ( 15 ) 頁: 1795 - 1801   2020年

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  77. Nasal patency as a factor for successful transnasal endoscopy

    Nagaya Toshihiko, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Nakashima Tsutomu, Nakata Sciichi, Hirooka Yoshiki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   81 巻 ( 4 ) 頁: 587 - 595   2019年11月

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  78. Mucinous cystic neoplasm of the pancreas assessed with a real-time three-dimensional imaging using a transesophageal echocardiography probe

    Ishikawa Takuya, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Fujishiro Mitsuhiro

    CLINICAL JOURNAL OF GASTROENTEROLOGY   12 巻 ( 5 ) 頁: 479 - 483   2019年10月

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  79. Feasibility and usefulness of endoscopic ultrasonography-guided shear-wave measurement for assessment of autoimmune pancreatitis activity: a prospective exploratory study

    Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Tanaka Hiroyuki, Sakai Daisuke, Ishizu Yoji, Kuzuya Teiji, Nakamura Masanao, Honda Takashi

    JOURNAL OF MEDICAL ULTRASONICS   46 巻 ( 4 ) 頁: 425 - 433   2019年10月

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  80. Increased hardness of the underlying pancreas correlates with the presence of intraductal papillary-mucinous neoplasm in a limited number of cases

    Koya Toshinari, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi, Hirooka Yoshiki

    JOURNAL OF MEDICAL ULTRASONICS   46 巻 ( 4 ) 頁: 441 - 447   2019年10月

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  81. Objective evaluation of the therapeutic effect of ustekinumab on Crohn's disease

    Yamamura T., Nakamura M., Murate K., Maeda K., Sawada T., Mizutani Y., Nishikawa T., Hattori S., Yamamoto K., Pu L. Zorron Cheng Tao, Ishikawa T., Furukawa K., Ohno E., Miyahara R., Kawashima H., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 145 - 145   2019年9月

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    記述言語:日本語  

    Web of Science

  82. Specific members of gut microbiota predict mucosal healing in Crohn's disease

    Hattori S., Nakamura M., Yamamura T., Maeda K., Sawada T., Mizutani Y., Yamamoto K., Pu L. Zorron Cheng Tao, Honda T., Ishikawa T., Furukawa K., Ohno E., Miyahara R., Kawashima H., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 152 - 152   2019年9月

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    記述言語:日本語  

    Web of Science

  83. THE PROPAGATION DISPLAY METHOD IMPROVES THE REPRODUCIBILITY OF PANCREATIC SHEAR WAVE ELASTOGRAPHY

    Hashizume Kiyotaka, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kawai Manabu, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Kuwahara Takamichi, Hashimoto Senju, Goto Hidemi

    ULTRASOUND IN MEDICINE AND BIOLOGY   45 巻 ( 8 ) 頁: 2242 - 2247   2019年8月

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  84. Comparison of 8- and 10-mm diameter fully covered self-expandable metal stents: A multicenter prospective study in patients with distal malignant biliary obstruction.

    Kawashima H, Hashimoto S, Ohno E, Ishikawa T, Morishima T, Matsubara H, Sugimoto H, Nonogaki K, Kanamori A, Hara K, Kuwahara T, Nakamura M, Miyahara R, Ishigami M, Ando M, Hirooka Y, Nagoya Biliary Stent Study (NABIS)-01 Group.

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   31 巻 ( 4 ) 頁: 439 - 447   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/den.13366

    PubMed

  85. CLINICAL SIGNIFICANCE OF THE PATENCY OF GASTROINTESTINAL TRACT IN CROHN'S DISEASE EVALUATED BY PATENCY CAPSULE

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Kuno Takeshi, Yamada Keisaku, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB333 - AB333   2019年6月

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    記述言語:日本語  

    Web of Science

  86. USEFULLNESS OF EUS-GUIDED SHEAR-WAVE MEASUREMENT (EUS-SWM) FOR THE ASSESSMENT OF ACTIVITIES OF AUTOIMMUNE PANCREATITIS; A PROSPECTIVE EXPLORATORY STUDY

    Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Tanaka Hiroyuki, Sakai Daisuke, Iida Tadashi, Nishio Ryo, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Miyahara Ryoji

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB608 - AB608   2019年6月

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    記述言語:日本語  

    Web of Science

  87. USEFULNESS OF THE FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE IN THE DIAGNOSIS OF INVASION DEPTH OF COLORECTAL NEOPLASIA

    Kuno Takeshi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Suzuki Hiroto, Esaki Masaya, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB324 - AB324   2019年6月

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    記述言語:日本語  

    Web of Science

  88. FACTORS RELATED TO MISSED COLORECTAL POLYPS ON COLON CAPSULE ENDOSCOPY IN CLINICAL PRACTICE

    Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Otsuka Hiroyuki, Suzuki Hiroto, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hotta Naoki, Pu Leonardo Zorron Cheng Tao, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB155 - AB155   2019年6月

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    記述言語:日本語  

    Web of Science

  89. Phase II study of chemoradiotherapy combined with gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic ductal adenocarcinoma (NUPAT 05 Trial): study protocol for a single arm phase II study

    Takano Nao, Yamada Suguru, Hirakawa Akihiro, Yokoyama Yukihiro, Kawashima Hiroki, Maeda Osamu, Okada Tohru, Ohno Eizaburo, Yamaguchi Junpei, Ishikawa Takuya, Sonohara Fuminori, Suenaga Masaya, Takami Hideki, Hayashi Masamichi, Niwa Yukiko, Hirooka Yoshiki, Ito Yoshiyuki, Naganawa Shinji, Ando Yuichi, Nagino Masato, Goto Hidemi, Fuji Tsutomu, Kodera Yasuhiro

    NAGOYA JOURNAL OF MEDICAL SCIENCE   81 巻 ( 2 ) 頁: 233 - 239   2019年5月

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  90. Utility of linked color imaging for endoscopic diagnosis of early gastric cancer

    Fujiyoshi Toshihisa, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Nakaguro Masato, Nakatochi Masahiro, Hirooka Yoshiki

    WORLD JOURNAL OF GASTROENTEROLOGY   25 巻 ( 10 ) 頁: 1248 - 1258   2019年3月

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  91. Transabdominal ultrasound elastography of the esophagogastric junction predicts reflux esophagitis

    Suhara Hiroki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi

    JOURNAL OF MEDICAL ULTRASONICS   46 巻 ( 1 ) 頁: 99 - 104   2019年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10396-018-0890-1

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  92. Randomized Phase II Study of Consecutive-Day versus Alternate-Day Treatment with S-1 as Second-Line Chemotherapy in Advanced Pancreatic Cancer.

    Ishikawa T, Kawashima H, Ohno E, Matsubara H, Sasaki Y, Achiwa K, Kanamori A, Sumi H, Hirai T, Nonogaki K, Tsuzuki T, Kuroiwa M, Hattori M, Maruta S, Hiramatsu T, Ando M, Hashimoto S, Hirooka Y

    Oncology   96 巻 ( 1 ) 頁: 1 - 7   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000492388

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  93. Plummer-Vinson Syndrome with Esophageal Web Formation in which Detailed Endoscopic Images Were Obtained

    Hirose Takashi, Funasaka Kohei, Furukawa Kazuhiro, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki

    INTERNAL MEDICINE   58 巻 ( 6 ) 頁: 785 - 789   2019年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1628-18

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  94. Clinical Impact of EUS-Guided Fine Needle Biopsy Using a Novel Franseen Needle for Histological Assessment of Pancreatic Diseases

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Tanaka Hiroyuki, Sakai Daisuke, Iida Tadashi, Nishio Ryo, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Miyahara Ryoji, Hashimoto Senju, Ishigami Masatoshi, Hirooka Yoshiki

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2019 巻   頁: 8581743   2019年

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    記述言語:日本語  

    DOI: 10.1155/2019/8581743

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  95. Lewis Score on Capsule Endoscopy as a Predictor of the Risk for Crohn's Disease-Related Emergency Hospitalization and Clinical Relapse in Patients with Small Bowel Crohn's Disease

    Nishikawa Takahiro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki

    GASTROENTEROLOGY RESEARCH AND PRACTICE   2019 巻   頁: 4274257   2019年

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    記述言語:日本語  

    DOI: 10.1155/2019/4274257

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  96. Feasibility of EUS-guided shear-wave measurement: A preliminary clinical study

    Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya

    ENDOSCOPIC ULTRASOUND   8 巻 ( 3 ) 頁: 215 - 216   2019年

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    記述言語:日本語  

    DOI: 10.4103/eus.eus_6_19

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  97. Validity of Capsule Endoscopy in Monitoring Therapeutic Interventions in Patients with Crohn's Disease

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Koulaouzidis Anastasios, Hirooka Yoshiki

    JOURNAL OF CLINICAL MEDICINE   7 巻 ( 10 )   2018年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/jcm7100311

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  98. Effectiveness of a modified 6-Fr endoscopic nasobiliary drainage catheter for patients with preoperative perihilar cholangiocarcinoma

    Kawashima Hiroki, Hirooka Yoshiki, Ohno Eizaburo, Ishikawa Takuya, Miyahara Ryoji, Watanabe Osamu, Hayashi Kazuhiko, Ishigami Masatoshi, Hashimoto Senju, Ebata Tomoki, Nagino Masato, Goto Hidemi

    ENDOSCOPY INTERNATIONAL OPEN   6 巻 ( 8 ) 頁: E1020 - E1030   2018年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/a-0614-2202

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  99. Objective evaluation of blood flow in the small-intestinal villous: quantification of findings from dynamic endoscopy with concomitant narrow-band imaging

    Takeyama Tomoaki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Goto Hidemi

    ENDOSCOPY INTERNATIONAL OPEN   6 巻 ( 8 ) 頁: E941 - E949   2018年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/a-0619-4965

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  100. Neuroendocrine neoplasm of pancreas with cystic degeneration mimicking mucinous cystic neoplasm

    Kaosombatwattana Uayporn, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Suhara Hiroki, Goto Hidemi

    CLINICAL JOURNAL OF GASTROENTEROLOGY   11 巻 ( 4 ) 頁: 333 - 337   2018年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s12328-018-0846-4

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  101. Increase in breath hydrogen concentration was correlated with the main pancreatic duct stenosis

    Sakai Daisuke, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Iida Tadashi, Nishio Ryo, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Tsuruta Akihiro, Shin Woosuck, Goto Hidemi

    JOURNAL OF BREATH RESEARCH   12 巻 ( 3 ) 頁: 036004   2018年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1088/1752-7163/aaaf77

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  102. Measurements of renal shear wave velocities in chronic kidney disease patients

    Sasaki Yutaka, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Takeshita Kyosuke, Goto Hidemi

    ACTA RADIOLOGICA   59 巻 ( 7 ) 頁: 884 - 890   2018年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1177/0284185117734417

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  103. International consensus statements on early chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with The International Association of Pancreatology, American Pancreatic Association, Japan Pancreas Society, PancreasFest Working Group and European Pancreatic Club.

    Whitcomb DC, Shimosegawa T, Chari ST, Forsmark CE, Frulloni L, Garg P, Hegyi P, Hirooka Y, Irisawa A, Ishikawa T, Isaji S, Lerch MM, Levy P, Masamune A, Wilcox CM, Windsor J, Yadav D, Sheel A, Neoptolemos JP, Working Group for the International (IAP – APA – JPS – EPC) Consensus Guidelines for Chronic Pancreatitis.

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   18 巻 ( 5 ) 頁: 516 - 527   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.pan.2018.05.008

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  104. DIAGNOSTIC IMAGING SYSTEM WITH VIRTUAL ENTEROSCOPY AND COMPUTER-AIDED DETECTION FOR EVALUATION OF SMALL BOWEL LESIONS OF CROHN'S DISEASE

    Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Suhara Hiroki, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Oda Masahiro, Mori Kensaku, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB304-AB304   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  105. USEFULNESS OF HISTOLOGICAL ASSESSMENT WITH EUS-GUIDED FINE NEEDLE BIOPSY USING A NEW CORE NEEDLE IN PANCREATIC DISEASES

    Ishikawa Takuya, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB432-AB433   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  106. USEFULLNESS OF CONTRAST-ENHANCED HARMONIC EUS(CH-EUS) FOR THE PREOPERATIVE ASSESSMENT OF MPD INVOLVEMENT IN IPMN; A RETROSPECTIVE COMPARISON STUDY OF CH-EUS AND IDUS

    Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Furukawa Kazuhiro, Yamamura Takeshi, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB426-AB427   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  107. THE DIAGNOSTIC ABILITY AND PITFALL OF JNET(JAPAN NBI EXPERT TEAM)CLASSIFICATION IN TRAINEES

    Suzuki Hiroto, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Niwa Yoshiki, Uchida Genta, Otsuka Hiroyuki, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keisaku, Hattori Shun, Kajikawa Go, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB489-AB490   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  108. OUTCOMES AND PREDICTORS OF SEVERE SUBMUCOSAL FIBROSIS IN COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION

    Kaosombatwattana Uayporn, Yamamura Takeshi, Limsrivilai Julajak, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Leelakusolvong Somchai, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB377-AB377   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  109. EVALUATION OF LOCAL RECURRENCE AFTER COLD POLYPECTOMY COMPARED WITH CONVENTIONAL HOT POLYPECTOMY IN A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL

    Yamamura Takeshi, Saito Masashi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Suzuki Hiroto, Otsuka Hiroyuki, Uchida Genta, Nishikawa Takahiro, Ishida Tetsuya, Kuno Takeshi, Yamada Keisaku, Hattori Shun, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB478-AB478   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  110. ENDOSCOPIC TREATMENT FOR SUPERFICIAL NON-AMPULLARY DUODENAL TUMORS

    Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Suhara Hiroki, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB315-AB316   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  111. PROSPECTIVE STUDY OF SMALL BOWEL CAPSULE ENDOSCOPY FOR EVALUATING THE THERAPEUTIC EFFECTS IN PATIENTS WITH CROHN'S DISEASE

    Nakamura Masanao, Hirooka Yoshiki, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Koulaouzidis Anastasios, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB393 - AB393   2018年6月

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    記述言語:日本語  

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  112. A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer

    Hirooka Yoshiki, Kasuya Hideki, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Villalobos Itzel B., Naoe Yoshinori, Ichinose Toru, Koyama Nobuto, Tanaka Maki, Kodera Yasuhiro, Goto Hidemi

    BMC CANCER   18 巻 ( 1 ) 頁: 596   2018年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s12885-018-4453-z

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  113. Fecal calprotectin reflects endoscopic activity in patients with small-bowel Crohn's disease according to double-balloon endoscopy findings

    Matsuura Rinzaburo, Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Suhara Hiroki, Furukawa Kazuhiro, Ishikawa Takuya, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   80 巻 ( 2 ) 頁: 257 - 266   2018年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18999/nagjms.80.2.257

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  114. Nomogram-based prediction of rebleeding in small bowel bleeding patients: the 'PRSBB' score

    Uchida Genta, Hirooka Yoshiki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi

    SCIENTIFIC REPORTS   8 巻 ( 1 ) 頁: 6378   2018年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-018-24868-0

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  115. Multiphase evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic solid lesions

    Ishikawa Takuya, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Hashizume Kiyotaka, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Goto Hidemi

    PANCREATOLOGY   18 巻 ( 3 ) 頁: 291 - 297   2018年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.pan.2018.02.002

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  116. Usefulness of shear wave elastography as a quantitative diagnosis of chronic pancreatitis

    Kuwahara Takamichi, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33 巻 ( 3 ) 頁: 756-761   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jgh.13926

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  117. Clinical significance of gastrointestinal patency evaluation by using patency capsule in Crohn's disease

    Yoshimura Toru, Hirooka Yoshiki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   80 巻 ( 1 ) 頁: 121 - 128   2018年2月

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  118. Comprehensive immunotherapy combined with intratumoral injection of zoledronate-pulsed dendritic cells, intravenous adoptive activated T lymphocyte and gemcitabine in unresectable locally advanced pancreatic carcinoma: a phase I/II trial

    Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kamigaki Takashi, Goto Shigenori, Takahara Masashi, Goto Hidemi

    ONCOTARGET   9 巻 ( 2 ) 頁: 2838 - 2847   2018年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18632/oncotarget.22974

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  119. Natural history of pancreatic cystic lesions: A multicenter prospective observational study for evaluating the risk of pancreatic cancer.

    Ohno E, Hirooka Y, Kawashima H, Ishikawa T, Kanamori A, Ishikawa H, Sasaki Y, Nonogaki K, Hara K, Hashimoto S, Matsubara H, Hirai T, Sumi H, Sugimoto H, Goto H, NSPINAL study group.

    Journal of gastroenterology and hepatology   33 巻 ( 1 ) 頁: 320 - 328   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jgh.13967

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  120. Functional Correlation Between the Pancreas and the Small Intestine in Humans: The First Evaluation Using a Newly Developed Enteroscopy

    Hayashi Daijuro, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kuwahara Takamichi, Kawai Manabu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi

    PANCREAS   47 巻 ( 5 ) 頁: 601 - 608   2018年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MPA.0000000000001039

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  121. Diagnostic yield of small histological cores obtained with a new EUS-guided fine needle biopsy system

    Ishikawa Takuya, Mohamed Rachid, Heitman Steven J., Turbide Christian, Kumar Puja R., Goto Hidemi, Hirooka Yoshiki, Belletrutti Paul J.

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   31 巻 ( 12 ) 頁: 5143 - 5149   2017年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00464-017-5580-3

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  122. Development and validation of a new scoring system to determine the necessity of small-bowel endoscopy in obscure gastrointestinal bleeding

    Uchida Genta, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    DIGESTIVE AND LIVER DISEASE   49 巻 ( 11 ) 頁: 1218 - 1224   2017年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.dld.2017.08.036

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  123. In vivo histological diagnosis for gastric cancer using endocytoscopy

    Tsurudome Issei, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Nakaguro Masato, Satou Akira, Hirooka Yoshiki, Goto Hidemi

    WORLD JOURNAL OF GASTROENTEROLOGY   23 巻 ( 37 ) 頁: 6894 - 6901   2017年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3748/wjg.v23.i37.6894

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  124. Making decision to treat with infliximab by the result of periodic surveillance with double-balloon endoscopy after ilectomy can obtain mucosal healing and avoid re-operation on patients with Crohn's disease for a long-term follow-up study

    Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Saito Masashi, Matsuura Rinzaburou, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keishi, Kuno Takeshi, Hattori Shun, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32 巻   頁: 287-287   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  125. ETV1 expression would be a predictive marker of malignancy in GIST

    Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32 巻   頁: 79-80   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  126. Clinical factors related to false-positive rates of patency capsule examination

    Sawada Tsunaki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Elzaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   10 巻 ( 8 ) 頁: 589 - 598   2017年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1177/1756283X17722744

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    PubMed

  127. Prospective multicenter phase II study of gemcitabine plus cisplatin in patients with unresectable gallbladder cancer

    Hirooka Yoshiki, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Nonogaki Koji, Kanamori Akira, Hirai Takanori, Uchida Hiroki, Shirai Osamu, Ishikawa Hideki, Goto Hidemi

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   80 巻 ( 1 ) 頁: 119-125   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00280-017-3341-6

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  128. Quantitative diagnosis of chronic pancreatitis using EUS elastography

    Kuwahara Takamichi, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kawai Manabu, Suhara Hiroki, Takeyama Tomoaki, Hashizume Kiyotaka, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY   52 巻 ( 7 ) 頁: 868 - 874   2017年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00535-016-1296-8

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  129. Predicting the Depth of Invasion of Esophageal Squamous Cell Carcinoma: Under Experience of Linked Colored Imaging With LED Light Source

    Kobayashi Kenichi, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB527-AB527   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  130. Establishment of a New Scoring System for Predicting the Necessity of Double-Balloon Endoscopy in Obscure Gastrointestinal Bleeding

    Uchida Genta, Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB300-AB300   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  131. The Study of Diagnostic Ability for the Colorectal Neoplasms by Imaged Enhanced Endoscopy Using by JNET (Japan NBI Expert Team) Classification

    Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Matsuura Rinzaburo, Saito Masashi, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB402-AB402   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  132. The Outcome of Treatment in Hypopharyngeal and Cervical Esophageal Carcinoma

    Fujiyoshi Toshihisa, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB597-AB598   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  133. One Year Follow-Up After Cold Polypectomy Compared With Hot Polypectomy for Small Colorectal Polyps - a Prospective Randomized Controlled Trial

    Saito Masashi, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB365-AB366   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  134. Objective Assessment of Jejunal Villous Blood Flow for Evaluating Pancreas-Jejunum Functional Correlation Using a Novel Image Analyzing System

    Takeyama Tomoaki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kawai Manabu, Suhara Hiroki, Hashizume Kiyotaka, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB319-AB320   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  135. Novel EMR Technique for Preoperative Diagnosis and Treatment of Submucosal Tumor in the Small Bowel at Double-Balloon Endoscopy

    Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB300-AB300   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  136. Clinical Factors Related to False Positive Rates of Patency Capsule Examination

    Sawada Tsunaki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB305-AB305   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  137. Risk factors for rebleeding and risk-based follow-up of obscure gastrointestinal bleeding after its initial diagnosis.

    Uchida G, Nakamura M, Watanabe O, Yamamura T, Matsushita M, Ishikawa T, Furukawa K, Funasaka K, Ohno E, Kawashima H, Miyahara R, Goto H, Hirooka Y

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   114 巻 ( 10 ) 頁: 1819-1829   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.11405/nisshoshi.114.1819

    PubMed

  138. An Unusual Case of Pancreatic Metastasis from Squamous Cell Carcinoma of the Lung Diagnosed by EUS-Guided Fine Needle Biopsy

    Ishikawa Takuya, Hirooka Yoshiki, Teman Carolin J., Goto Hidemi, Belletrutti Paul J.

    CASE REPORTS IN GASTROINTESTINAL MEDICINE   2017 巻   頁: 3212056   2017年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1155/2017/3212056

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    PubMed

▼全件表示

科研費 4

  1. 胆膵疾患の十二指腸主乳頭擦過採取による表在細菌叢プロファイル作成と臨床応用の探索

    研究課題/研究課題番号:21K19897  2021年7月 - 2024年3月

    科学研究費助成事業  挑戦的研究(萌芽)

    川嶋 啓揮, 大野 栄三郎, 石川 卓哉, 飯田 忠, 中村 正直

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    担当区分:研究分担者 

    本研究の目的は、胆膵疾患の十二指腸主乳頭(PV)のブラシ擦過採取による表層細菌叢プロファイル作成と将来の基礎研究・臨床応用の可能性を探索することである。Fusobacterium nucleatumと大腸癌の関連が報告され、膵癌についても腫瘍内細菌の存在が明らかとなり注目されている。しかし、膵癌以外の胆膵疾患に関する報告は乏しい。PVは胆管・膵管が開口し、病変を通過した胆汁・膵液にさらされており、直視下に低侵襲でサンプル採取出来る特徴をもつ。本研究はPV擦過採取による細菌叢解析を行い今後の胆膵疾患の表層細菌叢、手術検体による病変内細菌叢、PV表層細菌叢と臨床所見を比較検討できるかを探索する。

  2. 免疫チェックポイント阻害剤抵抗性を改善する革新的膵癌治療法の開発

    研究課題/研究課題番号:21K07941  2021年4月 - 2024年3月

    科学研究費助成事業  基盤研究(C)

    飯田 忠, 大野 栄三郎, 石川 卓哉, 川嶋 啓揮, 藤城 光弘

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    担当区分:研究分担者 

    膵がんに代表される難治がんは免疫チェックポイント阻害剤(以下ICI)に対して抵抗性であり、その原因としてCAFが重要な役割を担っている。近年の研究によりCAFを促進性から抑制性にリプログラム(CAF初期化)させることで抵抗性が改善される可能性が示唆されているがその有効性に関しては明らかとなっていない。我々はMeflinを指標とすることでCAF初期化薬の候補薬を既に同定しており、本研究ではこれらの薬剤とICIとの併用効果を検証し、間質をターゲットとした革新的新規治療法の確立を目指す。

  3. 膵疾患に対する超音波内視鏡検査の診断能向上を目的とした人工知能の臨床応用

    研究課題/研究課題番号:20K12689  2020年4月 - 2023年3月

    科学研究費助成事業  基盤研究(C)

    石川 卓哉, 大野 栄三郎, 川嶋 啓揮, 藤城 光弘

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    担当区分:研究代表者 

    配分額:3510000円 ( 直接経費:2700000円 、 間接経費:810000円 )

    膵癌は早期発見が困難な上に進行が早く、極めて予後不良である。超音波内視鏡検査(EUS)は体の表面からの超音波検査と違って消化管の空気や脂肪などの影響を受けにくく、小さな膵癌の診断にも有用とされる。近年では超音波用造影剤を組みあわせることで血行動態などさらに詳細な評価も可能となった。しかし、EUSは検査の特性上主観性が高く、術者の技量や経験によるところが大きい。一方、消化器内視鏡画像を用いた人工知能(AI)診断の有用性が報告されており、EUSの分野でも応用が期待される。本研究では、EUSで得られた画像をAIに機械学習させることで術者の技量や経験の差を軽減し、膵癌診断における新たな診断体系の確立を目指す。
    膵癌の予後改善のためには早期発見と適切な診断が必須である。画像診断技術の進歩により、膵臓に小腫瘤性病変が発見されるようになってきた。これらには癌の他に低悪性度腫瘍や良性疾患も含まれるが、良悪性診断は容易ではない。研究代表者らはこれまでに膵腫瘤の診断における、EUSに超音波用造影剤を組み合わせた造影EUSの有用性について報告してきた。しかし、EUSは主観性が高く、術者の技量や経験によるところも大きい。一方、消化器内視鏡画像を用いた人工知能(AI)による診断の有用性が報告され、医師の診断を補助する新たなツールとして期待されている。そこで本研究では、EUSで得られた画像をAIに機械学習させることで術者の技量や経験の差を軽減し、膵腫瘤診断における新たな診断体系の確立を目的とした。
    令和二年度は当院で膵腫瘤病変に対して行った造影EUSの画像データを抽出し、機械学習による解析を行うことを目標とした。AI診断の精度は元となる画像データが多ければ多いほど正確なものに近づくが、当施設で膵腫瘤性病変に対して行われる造影EUSが年間約50件あり、このうちAI解析に耐えうるだけの画像データが揃えられる症例数数を考慮し 、まずは膵癌、非膵癌症例それぞれ50例ずつの集積を目指した。その結果、現在までに膵癌58例、非膵癌61例の合計119例の画像データを集積した。
    得られた画像については研究協力者である名城大学電気電子工学科の力を借りて機械学習による解析を行っている。機械学習には、Attentionを使用したV-Netという手法を用いて学習・検証・テストを行った。まだ解析の途中段階であるが、3回の交差検証による膵癌・非膵癌の自動診断の感度、特異度、正診率の平均はそれぞれ83.3%、88.9%、86%であった。今後Attentionで重要視する領域を再分析、改善させることで、さらなる診断能向上が期待される。
    症例数としては当初の目標であった膵癌、非膵癌合計100例に対し、合計119例の症例を集積できた。
    機械学習による解析についても名城大学電気電子工学科の協力のもと、解析をすすめており、概ね順調に進展していると考えている。
    現在解析を行っているAIを用いた造影EUSによる膵腫瘤性病変に対する良悪性診断能の検討については、今後解析結果を令和3年4月の日本消化器病学会総会で発表予定であり、その後に論文化を目指す。
    また今後の計画として、造影EUS以外の膵疾患に対して行ったEUSを用いた検査について、AIの活用を検討している。現在、膵腫瘤性病変に対してEUSガイド下に穿刺生検(EUS-FNA)を行った検体について実体顕微鏡で撮影した画像を集積中である。EUS-FNA検体の組織学的診断可否に対する、Deep learningを用いたAIによる自動診断能についても今後解析予定である。

  4. 超音波内視鏡下エラストグラフィによる組織硬度測定による膵癌の臨床病理学的病態解析

    研究課題/研究課題番号:18K12054  2018年4月 - 2021年3月

    科学研究費助成事業  基盤研究(C)

    大野 栄三郎, 川嶋 啓揮, 廣岡 芳樹, 宮原 良二, 中村 正直, 石川 卓哉

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    担当区分:研究分担者 

    本研究課題では膵癌における「硬度」情報測定方法の確立及び「硬度」と膵癌の生物学的悪性度、分子生物学的特徴との関連を解明すべく研究を行った。新規硬度測定ツールであるEUS-shear wave elastographyは硬度計測に不安定性を示し、組織硬度評価にはヒストグラム解析を付加したStrain法が膵腫瘍硬度評価に安定した結果を示し、膵腫瘍の種類別に硬度が層別化されることを示した。膵癌の臨床病理学的特徴と硬度との関連では、高硬度の膵癌は切除後予後が有意に不良であることが示され、非切除例では抗がん剤治療の奏効期間と相関を認めた。現在組織硬度に関連する癌組織、CAFの遺伝子変異を解析中である。
    最新の膵癌治療戦略において、近年ではCAFをターゲットとして、膵癌関連間質の特徴を変化させることにより抗がん剤のドラッグデリバリを改善をはじめとして化学療法の奏功率を向上させる試みが行われている。膵癌組織に対して癌線維性間質を組織学的所見以外で正確に評価する腫瘍は確立していない。本研究結果ではEUSエラストグラフィを用いた組織硬度計測の不安定性の課題が残るため、より正確な組織硬度計測手法の開発が期待される。本研究課題の結果成果は膵癌病態解明及び膵癌に対する新規治療開発の基礎となることが期待される。