所属
医学部附属病院 消化器内科 講師
大学院担当
大学院医学系研究科
職名
講師
イシカワ タクヤ
石川 卓哉
ISHIKAWA Takuya
学位 2
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医学博士 （ 2011年3月 名古屋大学 ）
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医学学士 （ 2001年3月 名古屋大学 ）
研究分野 1
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ライフサイエンス / 消化器内科学 / 消化器内科学
現在の研究課題とSDGs 1
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膵疾患に対する超音波内視鏡検査の診断能向上を目的とした人工知能の臨床応用
学歴 1
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名古屋大学 医学系研究科 消化器内科学
2007年4月 - 2011年3月
国名： 日本国
論文 156
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Accuracy of Serum Leucine-Rich Alpha-2 Glycoprotein in Evaluating Endoscopic Disease Activity in Crohn's Disease
Kawamura Tatsuya, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Iida Tadashi, Mizutani Yasuyuki, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi
INFLAMMATORY BOWEL DISEASES 29 巻 ( 2 ) 頁： 245 - 253 2023年2月
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CO2 enterography in endoscopic retrograde cholangiography using double-balloon endoscopy: A randomized clinical trial
Murate Kentaro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Kida Yuichi, Esaki Masaya, Hamazaki Motonobu, Iida Tadashi, Mizutani Yasuyuki, Yamao Kentaro, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Kinoshita Fumie, Ando Masahiko, Kawashima Hiroki
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 2023年1月
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Efficacy of 1-kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double-blind, placebo-controlled pilot study
Ikegami Shuji, Nakamura Masanao, Honda Takashi, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Yamamoto Kenta, Furune Satoshi, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Ishigami Masatoshi, Kinoshita Fumie, Kadota Yoshihiro, Tochio Takumi, Shimomura Yoshiharu, Hirooka Yoshiki, Kawashima Hiroki
ALIMENTARY PHARMACOLOGY & THERAPEUTICS 2023年1月
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Diagnostic Performance of Endocytoscopy for Esophageal Eosinophilia
Hida Emiko, Muroi Koichi, Kakushima Naomi, Furune Satoshi, Ishikawa Eri, Mizutani Yasuyuki, Sawada Tsunaki, Keiko Maeda, Yamamura Takeshi, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Nakamura Masanao, Nishida Kazuki, Fujishiro Mitsuhiro, Kawashima Hiroki
DIGESTION 頁： 1 - 10 2023年1月
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Current Status of the Diagnosis of Early-Stage Pancreatic Ductal Adenocarcinoma
Nakaoka Kazunori, Ohno Eizaburo, Kawabe Naoto, Kuzuya Teiji, Funasaka Kohei, Nakagawa Yoshihito, Nagasaka Mitsuo, Ishikawa Takuya, Watanabe Ayako, Tochio Takumi, Miyahara Ryoji, Shibata Tomoyuki, Kawashima Hiroki, Hashimoto Senju, Hirooka Yoshiki
DIAGNOSTICS 13 巻 ( 2 ) 2023年1月
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Factors Related to Delayed Adverse Events of Endoscopic Submucosal Dissection in the Duodenum 査読有り
Kawamura Tatsuya, Hirose Takashi, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ishikawa Eri, Sawada Tsunaki, Keiko Maeda, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Fujishiro Mitsuhiro
DIGESTIVE DISEASES 41 巻 ( 1 ) 頁： 80 - 88 2023年1月
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Network Analysis of Gut Microbiota Including Fusobacterium and Oral Origin Bacteria and Their Distribution on Tumor Surface, Normal Mucosa, and in Feces in Patients with Colorectal Cancer
Ohashi Ayako, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Yamamoto Kenta, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro
DIGESTION 103 巻 ( 6 ) 頁： 451 - 461 2022年12月
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Analysis of immunologic comorbidities in ulcerative colitis patients: a tool to prevent exacerbations in ulcerative colitis cases
Meza Miguel Ricardo Rodriguez, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Iida Tadashi, Mizutani Yasuyuki, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi
NAGOYA JOURNAL OF MEDICAL SCIENCE 84 巻 ( 4 ) 頁： 733 - 745 2022年11月
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Author Correction: Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer.
Yoshikawa M, Ishikawa T, Ohno E, Iida T, Furukawa K, Nakamura M, Honda T, Ishigami M, Kinoshita F, Kawashima H, Fujishiro M
Scientific reports 12 巻 ( 1 ) 頁： 16190 2022年9月
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Modified N score is helpful for identifying patients who need endoscopic intervention among those with black stools without hematemesis
Ito Nobuhito, Funasaka Kohei, Fujiyoshi Toshihisa, Furukawa Kazuhiro, Kakushima Naomi, Furune Satoshi, Ishikawa Eri, Mizutani Yasuyuki, Sawada Tsunaki, Maeda Keiko, Ishikawa Takuya, Yamamura Takeshi, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Haruta Jun-Ichi, Fujishiro Mitsuhiro
DIGESTIVE ENDOSCOPY 34 巻 ( 6 ) 頁： 1157 - 1165 2022年9月
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Endoscopic management of perihilar cholangiocarcinoma
Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Mizutani Yasuyuki, Iida Tadashi, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao
DIGESTIVE ENDOSCOPY 34 巻 ( 6 ) 頁： 1147 - 1156 2022年9月
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Comparison of outcomes between secondary fully covered and uncovered self-expandable metal stents in the treatment of recurrent biliary obstruction of pancreatic cancer 査読有り
Kataoka Kunio, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Mizutani Yasuyuki, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 36 巻 ( 8 ) 頁： 5676 - 5683 2022年8月
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Fecal microbiota transplantation in the treatment of irritable bowel syndrome: a single-center prospective study in Japan
Hamazaki Motonobu, Sawada Tsunaki, Yamamura Takeshi, Maeda Keiko, Mizutani Yasuyuki, Ishikawa Eri, Furune Satoshi, Yamamoto Kenta, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Nakamura Masanao, Fujishiro Mitsuhiro
BMC GASTROENTEROLOGY 22 巻 ( 1 ) 頁： 342 2022年7月
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Comparison of an Inside Stent and a Fully Covered Self-Expandable Metallic Stent as Preoperative Biliary Drainage for Patients with Resectable Perihilar Cholangiocarcinoma
Mori Hiroshi, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Yamao Kentaro, Mizutani Yasuyuki, Iida Tadashi, Nakamura Masanao, Ishigami Masatoshi, Onoe Shunsuke, Mizuno Takashi, Ebata Tomoki, Fujishiro Mitsuhiro
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 2022 巻 頁： 3005210 2022年7月
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Endoscopic sphincterotomy and endoscopic biliary stenting do not affect the sensitivity of transpapillary forceps biopsy for the diagnosis of bile duct adenocarcinoma
Aoki Toshinori, Ohno Eizaburo, Ishikawa Takuya, Mizutani Yasuyuki, Iida Tadashi, Yamao Kentaro, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Yatsuya Hiroshi, Kawashima Hiroki
BMC GASTROENTEROLOGY 22 巻 ( 1 ) 頁： 329 2022年7月
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Factors associated with misdiagnosis of preoperative endoscopic ultrasound in patients with pancreatic cystic neoplasms undergoing surgical resection
Ohno Eizaburo, Ishikawa Takuya, Mizutani Yasuyuki, Iida Tadashi, Uetsuki Kota, Yashika Jun, Yamada Kenta, Gibo Noriaki, Aoki Toshinori, Kawashima Hiroki
JOURNAL OF MEDICAL ULTRASONICS 49 巻 ( 3 ) 頁： 433 - 441 2022年7月
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Results of a Phase II Study on the Use of Neoadjuvant Chemotherapy (FOLFIRINOX or GEM/nab-PTX) for Borderline-resectable Pancreatic Cancer (NUPAT-01) 査読有り
Yamaguchi Junpei, Yokoyama Yukihiro, Fujii Tsutomu, Yamada Suguru, Takami Hideki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Maeda Osamu, Ogawa Hiroshi, Kodera Yasuhiro, Nagino Masato, Ebata Tomoki
ANNALS OF SURGERY 275 巻 ( 6 ) 頁： 1043 - 1049 2022年6月
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Comparison of contrast-enhanced transabdominal ultrasonography following endoscopic ultrasonography with GD-EOB-DTPA-enhanced MRI for the sequential diagnosis of liver metastasis in patients with pancreatic cancer 査読有り
Ishikawa Takuya, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Koya Toshinari, Sasaki Yutaka, Ogawa Hiroshi, Kinoshita Fumie, Hirooka Yoshiki, Kawashima Hiroki
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES 29 巻 ( 6 ) 頁： 682 - 692 2022年6月
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Effects of steroid use for stenosis prevention after endoscopic submucosal dissection for cervical esophageal cancer 査読有り
Muroi Koichi, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ito Nobuhito, Hirose Takashi, Ishikawa Eri, Mizutani Yasuyuki, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Funasaka Kohei, Miyahara Ryoji, Fujishiro Mitsuhiro
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 27 巻 ( 5 ) 頁： 940 - 947 2022年5月
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Gelsolin as a Potential Biomarker for Endoscopic Activity and Mucosal Healing in Ulcerative Colitis
Maeda Keiko, Nakamura Masanao, Yamamura Takeshi, Sawada Tsunaki, Ishikawa Eri, Oishi Akina, Ikegami Shuji, Kakushima Naomi, Furukawa Kazuhiro, Iida Tadashi, Mizutani Yasuyuki, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki
BIOMEDICINES 10 巻 ( 4 ) 2022年4月
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Relationship between psoas muscle index and long-term survival in older patients aged >= 80 years after endoscopic submucosal dissection for gastric cancer
Ito Nobuhito, Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 27 巻 ( 4 ) 頁： 729 - 738 2022年4月
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Pancreatic acinar cell carcinoma with predominant extension into the main pancreatic duct: A case report.
Ishikawa T, Ohno E, Mizutani Y, Iida T, Kawashima H
DEN open 2 巻 ( 1 ) 頁： e96 2022年4月
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Diagnostic performance of endoscopic classifications for neoplastic lesions in patients with ulcerative colitis: A retrospective case-control study
Kida Yuichi, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Mizutani Yasuyuki, Kakushima Naomi, Furukawa Kazuhiro, Ishikawa Takuya, Ohno Eizaburo, Kawashima Hiroki, Nakamura Masanao, Ishigami Masatoshi, Fujishiro Mitsuhiro
WORLD JOURNAL OF GASTROENTEROLOGY 28 巻 ( 10 ) 頁： 1055 - 1066 2022年3月
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The impact of the age-adjusted Charlson comorbidity index as a prognostic factor for endoscopic papillectomy in ampullary tumors 査読有り
Takada Yoshihisa, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Mizutani Yasuyuki, Iida Tadashi, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Ito Akihiro, Hirooka Yoshiki
JOURNAL OF GASTROENTEROLOGY 57 巻 ( 3 ) 頁： 199 - 207 2022年3月
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Artificial intelligence-based diagnosis of upper gastrointestinal subepithelial lesions on endoscopic ultrasonography images 査読有り
Hirai Keiko, Kuwahara Takamichi, Furukawa Kazuhiro, Kakushima Naomi, Furune Satoshi, Yamamoto Hideko, Marukawa Takahiro, Asai Hiromitsu, Matsui Kenichi, Sasaki Yoji, Sakai Daisuke, Yamada Koji, Nishikawa Takahiro, Hayashi Daijuro, Obayashi Tomohiko, Komiyama Takuma, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro
GASTRIC CANCER 25 巻 ( 2 ) 頁： 382 - 391 2022年3月
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Fecal incontinence and oral regurgitation during duodenal endoscopic submucosal dissection using the water pressure method 査読有り
Takada Yoshihisa, Hirose Takashi, Nishida Kazuki, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Fujishiro Mitsuhiro
DIGESTIVE ENDOSCOPY 34 巻 ( 3 ) 頁： 526 - 534 2022年3月
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A novel scoring system to predict therapeutic intervention for non-variceal upper gastrointestinal bleeding 査読有り
Ito Nobuhito, Funasaka Kohei, Furukawa Kazuhiro, Kakushima Naomi, Hirose Takashi, Muroi Koichi, Suzuki Tomohiko, Suzuki Takahiro, Hida Emiko, Ishikawa Takuya, Yamamura Takeshi, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Fujishiro Mitsuhiro
INTERNAL AND EMERGENCY MEDICINE 17 巻 ( 2 ) 頁： 423 - 430 2022年3月
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Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma 査読有り
Mizutani Yasuyuki, Iida Tadashi, Ohno Eizaburo, Ishikawa Takuya, Kinoshita Fumie, Kuwatsuka Yachiyo, Imai Miwa, Shimizu Shinobu, Tsuruta Toshihisa, Enomoto Atsushi, Kawashima Hiroki, Fujishiro Mitsuhiro
BMC CANCER 22 巻 ( 1 ) 頁： 205 2022年2月
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Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients 査読有り
Nakamura Masanao, Maeda Keiko, Yamamoto Kenta, Yamamura Takeshi, Sawada Tsunaki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Iida Tadashi, Mizutani Yasuyuki, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki
DIGESTION 頁： 1 - 12 2022年2月
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Initial experience of tofacitinib for treating refractory moderate-to-severe ulcerative colitis 査読有り
Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro
NAGOYA JOURNAL OF MEDICAL SCIENCE 84 巻 ( 1 ) 頁： 169 - 179 2022年2月
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Development of a Novel Evaluation Method for Endoscopic Ultrasound-Guided Fine-Needle Biopsy in Pancreatic Diseases Using Artificial Intelligence 査読有り
Ishikawa Takuya, Hayakawa Masato, Suzuki Hirotaka, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Fujishiro Mitsuhiro, Kawashima Hiroki, Hotta Kazuhiro
DIAGNOSTICS 12 巻 ( 2 ) 2022年2月
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Usefulness of Macroscopic On-Site Evaluation Using a Stereomicroscope during EUS-FNB for Diagnosing Solid Pancreatic Lesions 査読有り
Ishikawa Takuya, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Uetsuki Kota, Yashika Jun, Yamada Kenta, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Takada Yoshihisa, Takahashi Hidekazu, Aoi Hironori, Kato Katsuyuki, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao, Hirooka Yoshiki, Kawashima Hiroki
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 2022 巻 頁： 2737578 2022年1月
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Current status of the diagnosis of chronic pancreatitis by ultrasonographic elastography 査読有り
Nakaoka Kazunori, Hashimoto Senju, Miyahara Ryoji, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kuwahara Takamichi, Tanaka Hiroyuki, Hirooka Yoshiki
KOREAN JOURNAL OF INTERNAL MEDICINE 37 巻 ( 1 ) 頁： 27 - 36 2022年1月
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Differentiation Between Solid Pseudopapillary Neoplasm of the Pancreas and Nonfunctional Pancreatic Neuroendocrine Neoplasm Using Endoscopic Ultrasound 査読有り
Kataoka Kunio, Ishikawa Takuya, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro
PANCREAS 51 巻 ( 1 ) 頁： 106 - 111 2022年1月
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Evaluation of ulcerative colitis activity using transabdominal ultrasound shear wave elastography 査読有り
Yamada Kenta, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Iida Tadashi, Ishikawa Eri, Mizutani Yasuyuki, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao, Ishigami Masatoshi, Fujishiro Mitsuhiro
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY 12 巻 ( 1 ) 頁： 618 - 626 2022年1月
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Fish bone migration after pancreaticoduodenectomy: Incidence and treatment options 査読有り
Takada Yoshihisa, Ishikawa Takuya, Kawashima Hiroki, Mizutani Yasuyuki, Ohno Eisaburo, Iida Tadashi, Ogawa Hiroshi, Hayashi Masamichi, Takami Hideki, Onoe Shunsuke, Ishigami Masatoshi
JOURNAL OF DIGESTIVE DISEASES 23 巻 ( 1 ) 頁： 44 - 49 2022年1月
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[Leptomeningeal carcinomatosis from duodenal papillary carcinoma].
Yamada K, Ohno E, Ishikawa T, Mizutani Y, Iida T, Uetsuki K, Yashika J, Aoki T, Mori H, Kawashima H
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 119 巻 ( 11 ) 頁： 1043 - 1047 2022年
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A Microfluidic Device with Check Valves to Detect Cancer using Caenorhabditis elegans
Shiga Hiromasa, Takeuchi Masaru, Kim Eunhye, Hisamoto Naoki, Ishikawa Takuya, Fukuda Toshio
2022 IEEE/SICE INTERNATIONAL SYMPOSIUM ON SYSTEM INTEGRATION (SII 2022) 頁： 969 - 970 2022年
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Comparison of Endoscopic Ultrasonography and Conventional Endoscopy for Prediction of Tumor Depth in Superficial Nonampullary Duodenal Epithelial Tumors
Matsuda Noritaka, Hirose Takashi, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Fujishiro Mitsuhiro
DIGESTION 103 巻 ( 4 ) 頁： 319 - 328 2022年
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Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching 査読有り
Saito Masashi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Mizutani Yasuyuki, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro
WORLD JOURNAL OF GASTROENTEROLOGY 27 巻 ( 47 ) 頁： 8182 - 8193 2021年12月
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Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival 査読有り
Yamada Kentaro, Sawada Tsunaki, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Ishikawa Eri, Iida Tadashi, Mizutani Yasuyuki, Kakushima Naomi, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Furune Satoshi, Hase Tetsunari, Yokota Kenji, Maeda Osamu, Hashimoto Naozumi, Akiyama Masashi, Ando Yuichi, Fujishiro Mitsuhiro
WORLD JOURNAL OF GASTROENTEROLOGY 27 巻 ( 41 ) 頁： 7190 - 7206 2021年11月
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Gastrointestinal: Pancreatic metastasis from extramammary Paget's disease diagnosed by endoscopic ultrasound-guided fine-needle biopsy 査読有り
Suzuki H., Ishikawa T., Ohno E., Kawashima H., Fujishiro M.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 36 巻 ( 11 ) 頁： 3000 - 3000 2021年11月
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Endocytoscopy Is Useful for the Diagnosis of Superficial Nonampullary Duodenal Epithelial Tumors 査読有り
Hirose Takashi, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Nishida Kazuki, Yokoi Takio, Kawashima Hiroki, Fujishiro Mitsuhiro
DIGESTION 102 巻 ( 6 ) 頁： 895 - 902 2021年11月
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Differentiation between pancreatic metastases from renal cell carcinoma and pancreatic neuroendocrine neoplasm using endoscopic ultrasound 査読有り
Kataoka Kunio, Ishikawa Takuya, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Ishikawa Eri, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro
PANCREATOLOGY 21 巻 ( 7 ) 頁： 1364 - 1370 2021年10月
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Imaging diagnosis of autoimmune pancreatitis using endoscopic ultrasonography 査読有り
Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Mizutani Yasuyuki, Fujishiro Mitsuhiro
JOURNAL OF MEDICAL ULTRASONICS 48 巻 ( 4 ) 頁： 543 - 553 2021年10月
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An Unusual Pancreatic Mass with Ductal Disruption: Benign or Malignant? Type 2 Autoimmune Pancreatitis 査読有り
Takada Yoshihisa, Ishikawa Takuya, Kawashima Hiroki
GASTROENTEROLOGY 161 巻 ( 4 ) 頁： 1113 - 1115 2021年10月
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Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms 査読有り
Esaki Masaya, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Suzuki Hiroto, Kuno Takeshi, Yamada Kentaro, Hasegawa Issei, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro
DIGESTION 102 巻 ( 5 ) 頁： 701 - 713 2021年9月
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A forward-viewing radial-array echoendoscope is useful for diagnosing the depth of colorectal neoplasia invasion 査読有り
Kuno Takeshi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Esaki Masaya, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 35 巻 ( 8 ) 頁： 4389 - 4398 2021年8月
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Feasibility of patency capsule and colon capsule endoscopy in patients with suspected gastrointestinal stenosis: a prospective study 査読有り
Otsuka Hiroyuki, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawade Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Iliroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro
NAGOYA JOURNAL OF MEDICAL SCIENCE 83 巻 ( 3 ) 頁： 419 - 430 2021年8月
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Detection of Colorectal Neoplasms Using Linked Color Imaging: A Prospective, Randomized, Tandem Colonoscon Trial 査読有り
Hasegawa Issei, Yamamura Takeshi, Suzuki Hiroto, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Nakamura Masanao, Fujishiro Mitsuhiro
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 19 巻 ( 8 ) 頁： 1708 - + 2021年8月
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Double common bile duct associated with pancreaticobiliary maljunction 査読有り
Yamada Kenta, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yoshikawa Masakatsu, Takami Hideki, Inokawa Yoshikuni, Uchida Hiroo, Kawashima Hiroki, Fujishiro Mitsuhiro
NAGOYA JOURNAL OF MEDICAL SCIENCE 83 巻 ( 3 ) 頁： 655 - 661 2021年8月
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Lewis score on capsule endoscopy can predict the prognosis in patients with small bowel lesions of Crohn's disease 査読有り
Nishikawa Takahiro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 36 巻 ( 7 ) 頁： 1851 - 1858 2021年7月
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Subjective Symptoms in Patients with Eosinophilic Esophagitis Are Related to Esophageal Wall Thickness and Esophageal Body Pressure 査読有り
Muroi Koichi, Kakushima Naomi, Furukawa Kazuhiro, Ishikawa Eri, Sawada Tsunaki, Ishikawa Takuya, Maeda Keiko, Yamamura Takeshi, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Funasaka Kohei, Miyahara Ryoji, Fujishiro Mitsuhiro
DIGESTIVE DISEASES AND SCIENCES 66 巻 ( 7 ) 頁： 2291 - 2300 2021年7月
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Endoscopic papillectomy for ampullary adenoma and early adenocarcinoma: Analysis of factors related to treatment outcome and long-term prognosis 査読有り
Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Tanaka Hiroyuki, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Hashimoto Senju, Itoh Akihiro, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro
DIGESTIVE ENDOSCOPY 33 巻 ( 5 ) 頁： 858 - 869 2021年7月
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Long-Term Prognostic Predictors of Esophageal Squamous Cell Carcinoma Potentially Indicated for Endoscopic Submucosal Dissection 査読有り
Suzuki Tomohiko, Furukawa Kazuhiro, Funasaka Kohei, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Fujishiro Mitsuhiro
DIGESTION 102 巻 ( 4 ) 頁： 563 - 571 2021年6月
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Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus 査読有り
Muroi Koichi, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Onoue Takeshi, Arima Hiroshi, Hirooka Yoshiki, Fujishiro Mitsuhiro
DIGESTION 102 巻 ( 4 ) 頁： 554 - 562 2021年6月
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Endosonography-guided transmural drainage of pancreatic fluid collections: comparative outcomes by stent type 査読有り
Kayal Ahmed, Taghizadeh Niloofar, Ishikawa Takuya, Gonzalez-Moreno Emmanuel, Bass Sydney, Cole Martin J., Heitman Steven J., Mohamed Rachid, Turbide Christian, Chen Yen- I, Forbes Nauzer
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 35 巻 ( 6 ) 頁： 2698 - 2708 2021年6月
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An evaluation of resectability among endoscopic treatment methods for rectal neuroendocrine tumors < 10 mm 査読有り
Toriyama Kazuhiro, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Furukawa Kazuhiro, Ishikawa Takuya, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro
ARAB JOURNAL OF GASTROENTEROLOGY 22 巻 ( 2 ) 頁： 104 - 110 2021年6月
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An initial trial of quantitative evaluation of autoimmune pancreatitis using shear wave elastography and shear wave dispersion in transabdominal ultrasound 査読有り
Suzuki Hirotaka, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Fujishiro Mitsuhiro
PANCREATOLOGY 21 巻 ( 4 ) 頁： 682 - 687 2021年6月
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Immunohistochemical staining for IMP3 in patients with duodenal papilla tumors: assessment of the potential for diagnosing endoscopic resectability and predicting prognosis 招待有り 査読有り
Tanaka Hiroyuki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Ishikawa Eri, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Shimoyama Yoshie, Miyahara Ryoji, Kawabe Naoto, Kuzuya Teiji, Hashimoto Senju, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro
BMC GASTROENTEROLOGY 21 巻 ( 1 ) 頁： 224 2021年5月
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Measurement of fasting breath hydrogen concentration as a simple diagnostic method for pancreatic exocrine insufficiency 査読有り
Uetsuki Kota, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Yamamoto Kenta, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro
BMC GASTROENTEROLOGY 21 巻 ( 1 ) 頁： 211 2021年5月
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Diagnostic performance of endoscopic ultrasonography-guided elastography for solid pancreatic lesions: Shear-wave measurements versus strain elastography with histogram analysis 査読有り
Ohno Eizaburo, Kawashima Hiroki, Ishikawa Takuya, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Hirooka Yoshiki, Fujishiro Mitsuhiro
DIGESTIVE ENDOSCOPY 33 巻 ( 4 ) 頁： 629 - 638 2021年5月
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Endoscopic removal of a fish bone piercing the bile duct after pancreaticoduodenectomy 査読有り
Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Nakamura Masanao, Yamada Suguru, Hayashi Masamichi, Fujishiro Mitsuhiro
ENDOSCOPY 53 巻 ( 05 ) 頁： E164 - E165 2021年5月
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Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy 査読有り
Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 2021 巻 頁： 8875564 2021年4月
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Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer 査読有り
Yoshikawa Masakatsu, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kinoshita Fumie, Kawashima Hiroki, Fujishiro Mitsuhiro
SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 7409 2021年4月
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Filtrated Adipose Tissue-Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice 査読有り
Nishikawa Takahiro, Maeda Keiko, Nakamura Masanao, Yamamura Takeshi, Sawada Tsunaki, Mizutani Yasuyuki, Ito Takanori, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Yamamoto Tokunori, Matsumoto Seiji, Hotta Yuji, Fujishiro Mitsuhiro
DIGESTIVE DISEASES AND SCIENCES 66 巻 ( 4 ) 頁： 1034 - 1044 2021年4月
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Utility of multiphase contrast enhancement patterns on CEH-EUS for the differential diagnosis of IPMN-derived and conventional pancreatic cancer
Yashika Jun, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Shimoyama Yoshie, Ishikawa Eri, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Hirooka Yoshiki, Kawashima Hiroki, Fujishiro Mitsuhiro
PANCREATOLOGY 21 巻 ( 2 ) 頁： 390 - 396 2021年3月
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Endoscopic ultrasound elastography for small solid pancreatic lesions with or without main pancreatic duct dilatation
Kataoka Kunio, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro
PANCREATOLOGY 21 巻 ( 2 ) 頁： 451 - 458 2021年3月
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Diagnostic yield of colon capsule endoscopy for Crohn's disease lesions in the whole gastrointestinal tract
Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro
BMC GASTROENTEROLOGY 21 巻 ( 1 ) 頁： 75 2021年2月
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Clinical characteristics and long-term prognosis of autoimmune pancreatitis with renal lesions
Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Hirooka Yoshiki, Fujishiro Mitsuhiro
SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 406 2021年1月
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Risks and characteristics of pancreatic cancer and pancreatic relapse in autoimmune pancreatitis patients
Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yamada Kenta, Yashika Jun, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Fujishiro Mitsuhiro
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 35 巻 ( 12 ) 頁： 2281 - 2288 2020年12月
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The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease
Hattori Shun, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Yamamoto Kenta, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro
JOURNAL OF GASTROENTEROLOGY 55 巻 ( 12 ) 頁： 1138 - 1149 2020年12月
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Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy
Niwa Yoshiki, Nakamura Masanao, Kawashima Hiroki, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro
WORLD JOURNAL OF GASTROENTEROLOGY 26 巻 ( 42 ) 頁： 6669 - 6678 2020年11月
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Mutation analysis of gastrointestinal stromal tumors using RNA obtained via endoscopic ultrasound-guided fine-needle aspiration
Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Hirooka Yoshiki, Ohmiya Naoki, Fujishiro Mitsuhiro
TRANSLATIONAL ONCOLOGY 13 巻 ( 11 ) 頁： 100848 2020年11月
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Endoscopic Activity and Serum TNF-alpha Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn's Disease Patients
Murate Kentaro, Maeda Keiko, Nakamura Masanao, Sugiyama Daisuke, Wada Hirotaka, Yamamura Takeshi, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Miyahara Ryoji, Ishigami Masatoshi, Nishikawa Hiroyoshi, Fujishiro Mitsuhiro
INFLAMMATORY BOWEL DISEASES 26 巻 ( 11 ) 頁： 1669 - 1681 2020年11月
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Usefulness of endoscopic ultrasound-guided fine-needle biopsy for the diagnosis of autoimmune pancreatitis using a 22-gauge Franseen needle: a prospective multicenter study
Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Suhara Hiroki, Hayashi Daijuro, Hiramatsu Takeshi, Matsubara Hiroshi, Suzuki Takahisa, Kuwahara Takamichi, Ishikawa Eri, Shimoyama Yoshie, Kinoshita Fumie, Hirooka Yoshiki, Fujishiro Mitsuhiro
ENDOSCOPY 52 巻 ( 11 ) 頁： 978 - 985 2020年11月
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AMINO ACID POLYMORPHISM IN HEPATITIS B VIRUS ASSOCIATED WITH NATURAL CLEARANCE OF HBV DNA AND HBsAg
Honda Takashi, Yamada None, Murayama Asako, Kato Asuka, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Ishigami Masatoshi, Murakami Yoshiki, Ishikawa Tetsuya, Fujishiro Mitsuhiro, Kato Takanobu
HEPATOLOGY 72 巻 頁： 508A - 509A 2020年11月
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What is the role of measuring shear wave dispersion using shear wave elastography in pancreatic parenchyma?
Suzuki Hirotaka, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Hashimoto Senju, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro
JOURNAL OF MEDICAL ULTRASONICS 47 巻 ( 4 ) 頁： 575 - 581 2020年10月
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Can contrast-enhanced harmonic endoscopic ultrasonography accurately diagnose main pancreatic duct involvement in intraductal papillary mucinous neoplasms?
Ohno Eizaburo, Kawashima Hiroki, Ishikawa Takuya, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Hirooka Yoshiki, Fujishiro Mitsuhiro
PANCREATOLOGY 20 巻 ( 5 ) 頁： 887 - 894 2020年7月
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Gender difference in the transabdominal ultrasound findings of solid-pseudopapillary neoplasm
Sasaki Yutaka, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Shimoyama Yoshie, Ishikawa Eri, Fujishiro Mitsuhiro
PANCREATOLOGY 20 巻 ( 5 ) 頁： 997 - 1003 2020年7月
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Giant fibrovascular polyp of the esophagus with intermittent airway obstruction
Ishikawa Takuya, Bishay Kirles, Belletrutti Paul J., Gui Xianyong, Forbes Nauzer
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 32 巻 ( 7 ) 頁： 895 - 896 2020年7月
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Endoscopic ultrasonography for the evaluation of pancreatic cystic neoplasms
Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Fujishiro Mitsuhiro
JOURNAL OF MEDICAL ULTRASONICS 47 巻 ( 3 ) 頁： 401 - 411 2020年7月
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Use of Immunostaining for the diagnosis of Lymphovascular invasion in superficial Barrett's esophageal adenocarcinoma
Hosono Isao, Miyahara Ryoji, Furukawa Kazuhiro, Funasaka Kohei, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Yokoi Takio, Hirooka Yoshiki, Fujishiro Mitsuhiro, Tsukamoto Tetsuya
BMC GASTROENTEROLOGY 20 巻 ( 1 ) 頁： 175 2020年6月
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ENDOSCOPIC DIAGNOSIS USING MAGNIFYING IMAGE-ENHANCED ENDOSCOPY FOR SUPERFICIAL NON-AMPULLARY DUODENAL EPITHELIAL TUMORS
Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Sawada Tsunaki, Keiko Maeda, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Fujishiro Mitsuhiro
GASTROINTESTINAL ENDOSCOPY 91 巻 ( 6 ) 頁： AB618 - AB618 2020年6月
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EVALUATION OF RESECTABILITY BETWEEN ENDOSCOPIC TREATMENT METHODS FOR RECTAL NEUROENDOCRINE TUMOR
Toriyama Kazuhiro, Yamamura Takeshi, Nakamura Masanao, Keiko Maeda, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro
GASTROINTESTINAL ENDOSCOPY 91 巻 ( 6 ) 頁： AB101 - AB101 2020年6月
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NOVEL METHOD TO DETERMINE THE DEPTH OF INVASION IN COLORECTAL NEOPLASMS WITH ULTRASOUND ELASTOGRAPHY USING A FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE
Esaki Masaya, Yamamura Takeshi, Nakamura Masanao, Keiko Maeda, Sawada Tsunaki, Mizutani Yasuyuki, Kuno Takeshi, Yamada Kentaro, Hasegawa Issei, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro
GASTROINTESTINAL ENDOSCOPY 91 巻 ( 6 ) 頁： AB430 - AB430 2020年6月
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PROSPECTIVE MULTICENTER STUDY ON THE USEFULNESS OF EUS-GUIDED FINE NEEDLE BIOPSY FOR THE DIAGNOSIS OF AUTOIMMUNE PANCREATITIS USING A 22-GAUGE FRANSEEN NEEDLE
Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yamada Kenta, Yashika Jun, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Keiko Maeda, Sawada Tsunaki, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Fujishiro Mitsuhiro
GASTROINTESTINAL ENDOSCOPY 91 巻 ( 6 ) 頁： AB172 - AB172 2020年6月
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Clinical Factors Associated with Missing Colorectal Polyp on Colon Capsule Endoscopy
Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hotta Naoki, Hirooka Yoshiki
DIGESTION 101 巻 ( 3 ) 頁： 316 - 322 2020年5月
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Diagnosis of vascular invasion in pancreatic ductal adenocarcinoma using endoscopic ultrasound elastography
Yamada Kenta, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Tanaka Hiroyuki, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro
BMC GASTROENTEROLOGY 20 巻 ( 1 ) 頁： 81 2020年3月
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Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study
Nishio Ryo, Kawashima Hiroki, Nakamura Masanao, Ohno Eizaburo, Ishikawa Takuya, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Tanaka Hiroyuki, Sakai Daisuke, Miyahara Ryoji, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro
WORLD JOURNAL OF GASTROENTEROLOGY 26 巻 ( 10 ) 頁： 1056 - 1066 2020年3月
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Usefulness of Endoscopic Ultrasound Elastography Combined With the Strain Ratio in the Estimation of Treatment Effect in Autoimmune Pancreatitis
Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Tanaka Hiroyuki, Maeda Keiko, Sawada Tsunaki, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Fujishiro Mitsuhiro
PANCREAS 49 巻 ( 2 ) 頁： E21 - E22 2020年2月
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Color information from linked color imaging is associated with invasion depth and vascular diameter in superficial esophageal squamous cell carcinoma
Kobayashi Kenichi, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Nakaguro Masato, Okumura Yuki, Hirooka Yoshiki, Fujishiro Mitsuhiro
DIGESTIVE ENDOSCOPY 32 巻 ( 1 ) 頁： 65 - 73 2020年1月
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Generation of magnifying endoscopic images of gastric neoplasms based on an all-in-focus algorithm
Matsui Kenichi, Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Ohara Kenichi, Hirooka Yoshiki, Goto Hidemi
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 35 巻 ( 1 ) 頁： 65 - 70 2020年1月
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A Prospective Study of Factors Associated with Abdominal Pain in Patients during Unsedated Colonoscopy Using a Magnifying Endoscope
Suzuki Hiroto, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro
INTERNAL MEDICINE 59 巻 ( 15 ) 頁： 1795 - 1801 2020年
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Nasal patency as a factor for successful transnasal endoscopy
Nagaya Toshihiko, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Nakashima Tsutomu, Nakata Sciichi, Hirooka Yoshiki
NAGOYA JOURNAL OF MEDICAL SCIENCE 81 巻 ( 4 ) 頁： 587 - 595 2019年11月
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Mucinous cystic neoplasm of the pancreas assessed with a real-time three-dimensional imaging using a transesophageal echocardiography probe
Ishikawa Takuya, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Fujishiro Mitsuhiro
CLINICAL JOURNAL OF GASTROENTEROLOGY 12 巻 ( 5 ) 頁： 479 - 483 2019年10月
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Feasibility and usefulness of endoscopic ultrasonography-guided shear-wave measurement for assessment of autoimmune pancreatitis activity: a prospective exploratory study
Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Tanaka Hiroyuki, Sakai Daisuke, Ishizu Yoji, Kuzuya Teiji, Nakamura Masanao, Honda Takashi
JOURNAL OF MEDICAL ULTRASONICS 46 巻 ( 4 ) 頁： 425 - 433 2019年10月
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Increased hardness of the underlying pancreas correlates with the presence of intraductal papillary-mucinous neoplasm in a limited number of cases
Koya Toshinari, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi, Hirooka Yoshiki
JOURNAL OF MEDICAL ULTRASONICS 46 巻 ( 4 ) 頁： 441 - 447 2019年10月
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Objective evaluation of the therapeutic effect of ustekinumab on Crohn's disease
Yamamura T., Nakamura M., Murate K., Maeda K., Sawada T., Mizutani Y., Nishikawa T., Hattori S., Yamamoto K., Pu L. Zorron Cheng Tao, Ishikawa T., Furukawa K., Ohno E., Miyahara R., Kawashima H., Fujishiro M.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 34 巻 頁： 145 - 145 2019年9月
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Specific members of gut microbiota predict mucosal healing in Crohn's disease
Hattori S., Nakamura M., Yamamura T., Maeda K., Sawada T., Mizutani Y., Yamamoto K., Pu L. Zorron Cheng Tao, Honda T., Ishikawa T., Furukawa K., Ohno E., Miyahara R., Kawashima H., Fujishiro M.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 34 巻 頁： 152 - 152 2019年9月
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THE PROPAGATION DISPLAY METHOD IMPROVES THE REPRODUCIBILITY OF PANCREATIC SHEAR WAVE ELASTOGRAPHY
Hashizume Kiyotaka, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kawai Manabu, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Kuwahara Takamichi, Hashimoto Senju, Goto Hidemi
ULTRASOUND IN MEDICINE AND BIOLOGY 45 巻 ( 8 ) 頁： 2242 - 2247 2019年8月
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Comparison of 8-and 10-mm diameter fully covered self-expandable metal stents: A multicenter prospective study in patients with distal malignant biliary obstruction
Kawashima Hiroki, Hashimoto Senju, Ohno Eizaburo, Ishikawa Takuya, Morishima Tomomasa, Matsubara Hiroshi, Sugimoto Hiroyuki, Nonogaki Koji, Kanamori Akira, Hara Kazuo, Kuwahara Takamichi, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Ando Masahiko, Hirooka Yoshiki
DIGESTIVE ENDOSCOPY 31 巻 ( 4 ) 頁： 439 - 447 2019年7月
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CLINICAL SIGNIFICANCE OF THE PATENCY OF GASTROINTESTINAL TRACT IN CROHN'S DISEASE EVALUATED BY PATENCY CAPSULE
Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Kuno Takeshi, Yamada Keisaku, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki
GASTROINTESTINAL ENDOSCOPY 89 巻 ( 6 ) 頁： AB333 - AB333 2019年6月
-
USEFULLNESS OF EUS-GUIDED SHEAR-WAVE MEASUREMENT (EUS-SWM) FOR THE ASSESSMENT OF ACTIVITIES OF AUTOIMMUNE PANCREATITIS; A PROSPECTIVE EXPLORATORY STUDY
Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Tanaka Hiroyuki, Sakai Daisuke, Iida Tadashi, Nishio Ryo, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Miyahara Ryoji
GASTROINTESTINAL ENDOSCOPY 89 巻 ( 6 ) 頁： AB608 - AB608 2019年6月
-
USEFULNESS OF THE FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE IN THE DIAGNOSIS OF INVASION DEPTH OF COLORECTAL NEOPLASIA
Kuno Takeshi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Suzuki Hiroto, Esaki Masaya, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki
GASTROINTESTINAL ENDOSCOPY 89 巻 ( 6 ) 頁： AB324 - AB324 2019年6月
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FACTORS RELATED TO MISSED COLORECTAL POLYPS ON COLON CAPSULE ENDOSCOPY IN CLINICAL PRACTICE
Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Otsuka Hiroyuki, Suzuki Hiroto, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hotta Naoki, Pu Leonardo Zorron Cheng Tao, Hirooka Yoshiki
GASTROINTESTINAL ENDOSCOPY 89 巻 ( 6 ) 頁： AB155 - AB155 2019年6月
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Phase II study of chemoradiotherapy combined with gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic ductal adenocarcinoma (NUPAT 05 Trial): study protocol for a single arm phase II study
Takano Nao, Yamada Suguru, Hirakawa Akihiro, Yokoyama Yukihiro, Kawashima Hiroki, Maeda Osamu, Okada Tohru, Ohno Eizaburo, Yamaguchi Junpei, Ishikawa Takuya, Sonohara Fuminori, Suenaga Masaya, Takami Hideki, Hayashi Masamichi, Niwa Yukiko, Hirooka Yoshiki, Ito Yoshiyuki, Naganawa Shinji, Ando Yuichi, Nagino Masato, Goto Hidemi, Fuji Tsutomu, Kodera Yasuhiro
NAGOYA JOURNAL OF MEDICAL SCIENCE 81 巻 ( 2 ) 頁： 233 - 239 2019年5月
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Utility of linked color imaging for endoscopic diagnosis of early gastric cancer
Fujiyoshi Toshihisa, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Nakaguro Masato, Nakatochi Masahiro, Hirooka Yoshiki
WORLD JOURNAL OF GASTROENTEROLOGY 25 巻 ( 10 ) 頁： 1248 - 1258 2019年3月
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Transabdominal ultrasound elastography of the esophagogastric junction predicts reflux esophagitis
Suhara Hiroki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi
JOURNAL OF MEDICAL ULTRASONICS 46 巻 ( 1 ) 頁： 99 - 104 2019年1月
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Randomized Phase II Study of Consecutive-Day versus Alternate-Day Treatment with S-1 as Second-Line Chemotherapy in Advanced Pancreatic Cancer
Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Matsubara Hiroshi, Sasaki Yoji, Achiwa Koichi, Kanamori Akira, Sumi Hajime, Hirai Takanori, Nonogaki Koji, Tsuzuki Tomoyuki, Kuroiwa Masanori, Hattori Masashi, Maruta Shinya, Hiramatsu Takeshi, Ando Masahiko, Hashimoto Senju, Hirooka Yoshiki
ONCOLOGY 96 巻 ( 1 ) 頁： 1 - 7 2019年
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Plummer-Vinson Syndrome with Esophageal Web Formation in which Detailed Endoscopic Images Were Obtained
Hirose Takashi, Funasaka Kohei, Furukawa Kazuhiro, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki
INTERNAL MEDICINE 58 巻 ( 6 ) 頁： 785 - 789 2019年
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Clinical Impact of EUS-Guided Fine Needle Biopsy Using a Novel Franseen Needle for Histological Assessment of Pancreatic Diseases
Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Tanaka Hiroyuki, Sakai Daisuke, Iida Tadashi, Nishio Ryo, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Miyahara Ryoji, Hashimoto Senju, Ishigami Masatoshi, Hirooka Yoshiki
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 2019 巻 頁： 8581743 2019年
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Lewis Score on Capsule Endoscopy as a Predictor of the Risk for Crohn's Disease-Related Emergency Hospitalization and Clinical Relapse in Patients with Small Bowel Crohn's Disease
Nishikawa Takahiro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki
GASTROENTEROLOGY RESEARCH AND PRACTICE 2019 巻 頁： 4274257 2019年
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Feasibility of EUS-guided shear-wave measurement: A preliminary clinical study
Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya
ENDOSCOPIC ULTRASOUND 8 巻 ( 3 ) 頁： 215 - 216 2019年
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Validity of Capsule Endoscopy in Monitoring Therapeutic Interventions in Patients with Crohn's Disease
Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Koulaouzidis Anastasios, Hirooka Yoshiki
JOURNAL OF CLINICAL MEDICINE 7 巻 ( 10 ) 2018年10月
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Effectiveness of a modified 6-Fr endoscopic nasobiliary drainage catheter for patients with preoperative perihilar cholangiocarcinoma
Kawashima Hiroki, Hirooka Yoshiki, Ohno Eizaburo, Ishikawa Takuya, Miyahara Ryoji, Watanabe Osamu, Hayashi Kazuhiko, Ishigami Masatoshi, Hashimoto Senju, Ebata Tomoki, Nagino Masato, Goto Hidemi
ENDOSCOPY INTERNATIONAL OPEN 6 巻 ( 8 ) 頁： E1020 - E1030 2018年8月
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Objective evaluation of blood flow in the small-intestinal villous: quantification of findings from dynamic endoscopy with concomitant narrow-band imaging
Takeyama Tomoaki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Goto Hidemi
ENDOSCOPY INTERNATIONAL OPEN 6 巻 ( 8 ) 頁： E941 - E949 2018年8月
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Neuroendocrine neoplasm of pancreas with cystic degeneration mimicking mucinous cystic neoplasm
Kaosombatwattana Uayporn, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Suhara Hiroki, Goto Hidemi
CLINICAL JOURNAL OF GASTROENTEROLOGY 11 巻 ( 4 ) 頁： 333 - 337 2018年8月
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Increase in breath hydrogen concentration was correlated with the main pancreatic duct stenosis
Sakai Daisuke, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Iida Tadashi, Nishio Ryo, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Tsuruta Akihiro, Shin Woosuck, Goto Hidemi
JOURNAL OF BREATH RESEARCH 12 巻 ( 3 ) 頁： 036004 2018年7月
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Measurements of renal shear wave velocities in chronic kidney disease patients
Sasaki Yutaka, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Takeshita Kyosuke, Goto Hidemi
ACTA RADIOLOGICA 59 巻 ( 7 ) 頁： 884 - 890 2018年7月
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International consensus statements on early chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with The International Association of Pancreatology, American Pancreatic Association, Japan Pancreas Society, PancreasFest Working Group and European Pancreatic Club
Whitcomb David C., Shimosegawa Tooru, Chari Suresh T., Forsmark Christopher E., Frulloni Luca, Garg Pramod, Hegyi Peter, Hirooka Yoshiki, Irisawa Atsushi, Ishikawa Takuya, Isaji Shuiji, Lerch Markus M., Levy Philippe, Masamune Atsushi, Wilcox Charles M., Windsor John, Yadav Dhiraj, Sheel Andrea, Neoptolemos John P.
PANCREATOLOGY 18 巻 ( 5 ) 頁： 516 - 527 2018年7月
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DIAGNOSTIC IMAGING SYSTEM WITH VIRTUAL ENTEROSCOPY AND COMPUTER-AIDED DETECTION FOR EVALUATION OF SMALL BOWEL LESIONS OF CROHN'S DISEASE
Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Suhara Hiroki, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Oda Masahiro, Mori Kensaku, Hirooka Yoshiki, Goto Hidemi
GASTROINTESTINAL ENDOSCOPY 87 巻 ( 6 ) 頁： AB304-AB304 2018年6月
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USEFULNESS OF HISTOLOGICAL ASSESSMENT WITH EUS-GUIDED FINE NEEDLE BIOPSY USING A NEW CORE NEEDLE IN PANCREATIC DISEASES
Ishikawa Takuya, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi
GASTROINTESTINAL ENDOSCOPY 87 巻 ( 6 ) 頁： AB432-AB433 2018年6月
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USEFULLNESS OF CONTRAST-ENHANCED HARMONIC EUS(CH-EUS) FOR THE PREOPERATIVE ASSESSMENT OF MPD INVOLVEMENT IN IPMN; A RETROSPECTIVE COMPARISON STUDY OF CH-EUS AND IDUS
Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Furukawa Kazuhiro, Yamamura Takeshi, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi
GASTROINTESTINAL ENDOSCOPY 87 巻 ( 6 ) 頁： AB426-AB427 2018年6月
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THE DIAGNOSTIC ABILITY AND PITFALL OF JNET(JAPAN NBI EXPERT TEAM)CLASSIFICATION IN TRAINEES
Suzuki Hiroto, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Niwa Yoshiki, Uchida Genta, Otsuka Hiroyuki, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keisaku, Hattori Shun, Kajikawa Go, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi
GASTROINTESTINAL ENDOSCOPY 87 巻 ( 6 ) 頁： AB489-AB490 2018年6月
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OUTCOMES AND PREDICTORS OF SEVERE SUBMUCOSAL FIBROSIS IN COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION
Kaosombatwattana Uayporn, Yamamura Takeshi, Limsrivilai Julajak, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Leelakusolvong Somchai, Hirooka Yoshiki, Goto Hidemi
GASTROINTESTINAL ENDOSCOPY 87 巻 ( 6 ) 頁： AB377-AB377 2018年6月
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EVALUATION OF LOCAL RECURRENCE AFTER COLD POLYPECTOMY COMPARED WITH CONVENTIONAL HOT POLYPECTOMY IN A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL
Yamamura Takeshi, Saito Masashi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Suzuki Hiroto, Otsuka Hiroyuki, Uchida Genta, Nishikawa Takahiro, Ishida Tetsuya, Kuno Takeshi, Yamada Keisaku, Hattori Shun, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi
GASTROINTESTINAL ENDOSCOPY 87 巻 ( 6 ) 頁： AB478-AB478 2018年6月
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ENDOSCOPIC TREATMENT FOR SUPERFICIAL NON-AMPULLARY DUODENAL TUMORS
Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Suhara Hiroki, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi
GASTROINTESTINAL ENDOSCOPY 87 巻 ( 6 ) 頁： AB315-AB316 2018年6月
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PROSPECTIVE STUDY OF SMALL BOWEL CAPSULE ENDOSCOPY FOR EVALUATING THE THERAPEUTIC EFFECTS IN PATIENTS WITH CROHN'S DISEASE
Nakamura Masanao, Hirooka Yoshiki, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Koulaouzidis Anastasios, Goto Hidemi
GASTROINTESTINAL ENDOSCOPY 87 巻 ( 6 ) 頁： AB393 - AB393 2018年6月
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A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer
Hirooka Yoshiki, Kasuya Hideki, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Villalobos Itzel B., Naoe Yoshinori, Ichinose Toru, Koyama Nobuto, Tanaka Maki, Kodera Yasuhiro, Goto Hidemi
BMC CANCER 18 巻 ( 1 ) 頁： 596 2018年5月
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Fecal calprotectin reflects endoscopic activity in patients with small-bowel Crohn's disease according to double-balloon endoscopy findings
Matsuura Rinzaburo, Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Suhara Hiroki, Furukawa Kazuhiro, Ishikawa Takuya, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi
NAGOYA JOURNAL OF MEDICAL SCIENCE 80 巻 ( 2 ) 頁： 257 - 266 2018年5月
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Nomogram-based prediction of rebleeding in small bowel bleeding patients: the 'PRSBB' score
Uchida Genta, Hirooka Yoshiki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi
SCIENTIFIC REPORTS 8 巻 ( 1 ) 頁： 6378 2018年4月
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Multiphase evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic solid lesions
Ishikawa Takuya, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Hashizume Kiyotaka, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Goto Hidemi
PANCREATOLOGY 18 巻 ( 3 ) 頁： 291 - 297 2018年4月
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Usefulness of shear wave elastography as a quantitative diagnosis of chronic pancreatitis
Kuwahara Takamichi, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 33 巻 ( 3 ) 頁： 756-761 2018年3月
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Clinical significance of gastrointestinal patency evaluation by using patency capsule in Crohn's disease
Yoshimura Toru, Hirooka Yoshiki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi
NAGOYA JOURNAL OF MEDICAL SCIENCE 80 巻 ( 1 ) 頁： 121 - 128 2018年2月
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Comprehensive immunotherapy combined with intratumoral injection of zoledronate-pulsed dendritic cells, intravenous adoptive activated T lymphocyte and gemcitabine in unresectable locally advanced pancreatic carcinoma: a phase I/II trial
Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kamigaki Takashi, Goto Shigenori, Takahara Masashi, Goto Hidemi
ONCOTARGET 9 巻 ( 2 ) 頁： 2838 - 2847 2018年1月
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Natural history of pancreatic cystic lesions: A multicenter prospective observational study for evaluating the risk of pancreatic cancer
Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Kanamori Akira, Ishikawa Hideki, Sasaki Yoji, Nonogaki Koji, Hara Kazuo, Hashimoto Senju, Matsubara Hiroshi, Hirai Takanori, Sumi Hajime, Sugimoto Hiroyuki, Goto Hidemi
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 33 巻 ( 1 ) 頁： 320 - 328 2018年1月
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Functional Correlation Between the Pancreas and the Small Intestine in Humans: The First Evaluation Using a Newly Developed Enteroscopy
Hayashi Daijuro, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kuwahara Takamichi, Kawai Manabu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi
PANCREAS 47 巻 ( 5 ) 頁： 601 - 608 2018年
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Diagnostic yield of small histological cores obtained with a new EUS-guided fine needle biopsy system
Ishikawa Takuya, Mohamed Rachid, Heitman Steven J., Turbide Christian, Kumar Puja R., Goto Hidemi, Hirooka Yoshiki, Belletrutti Paul J.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 31 巻 ( 12 ) 頁： 5143 - 5149 2017年12月
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Development and validation of a new scoring system to determine the necessity of small-bowel endoscopy in obscure gastrointestinal bleeding
Uchida Genta, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki
DIGESTIVE AND LIVER DISEASE 49 巻 ( 11 ) 頁： 1218 - 1224 2017年11月
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In vivo histological diagnosis for gastric cancer using endocytoscopy
Tsurudome Issei, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Nakaguro Masato, Satou Akira, Hirooka Yoshiki, Goto Hidemi
WORLD JOURNAL OF GASTROENTEROLOGY 23 巻 ( 37 ) 頁： 6894 - 6901 2017年10月
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Making decision to treat with infliximab by the result of periodic surveillance with double-balloon endoscopy after ilectomy can obtain mucosal healing and avoid re-operation on patients with Crohn's disease for a long-term follow-up study
Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Saito Masashi, Matsuura Rinzaburou, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keishi, Kuno Takeshi, Hattori Shun, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 32 巻 頁： 287-287 2017年9月
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ETV1 expression would be a predictive marker of malignancy in GIST
Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 32 巻 頁： 79-80 2017年9月
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Clinical factors related to false-positive rates of patency capsule examination
Sawada Tsunaki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Elzaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY 10 巻 ( 8 ) 頁： 589 - 598 2017年8月
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Quantitative diagnosis of chronic pancreatitis using EUS elastography
Kuwahara Takamichi, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kawai Manabu, Suhara Hiroki, Takeyama Tomoaki, Hashizume Kiyotaka, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi
JOURNAL OF GASTROENTEROLOGY 52 巻 ( 7 ) 頁： 868 - 874 2017年7月
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Prospective multicenter phase II study of gemcitabine plus cisplatin in patients with unresectable gallbladder cancer
Hirooka Yoshiki, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Nonogaki Koji, Kanamori Akira, Hirai Takanori, Uchida Hiroki, Shirai Osamu, Ishikawa Hideki, Goto Hidemi
CANCER CHEMOTHERAPY AND PHARMACOLOGY 80 巻 ( 1 ) 頁： 119-125 2017年7月
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Predicting the Depth of Invasion of Esophageal Squamous Cell Carcinoma: Under Experience of Linked Colored Imaging With LED Light Source
Kobayashi Kenichi, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi
GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB527-AB527 2017年5月
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Establishment of a New Scoring System for Predicting the Necessity of Double-Balloon Endoscopy in Obscure Gastrointestinal Bleeding
Uchida Genta, Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki
GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB300-AB300 2017年5月
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The Study of Diagnostic Ability for the Colorectal Neoplasms by Imaged Enhanced Endoscopy Using by JNET (Japan NBI Expert Team) Classification
Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Matsuura Rinzaburo, Saito Masashi, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi
GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB402-AB402 2017年5月
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The Outcome of Treatment in Hypopharyngeal and Cervical Esophageal Carcinoma
Fujiyoshi Toshihisa, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi
GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB597-AB598 2017年5月
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One Year Follow-Up After Cold Polypectomy Compared With Hot Polypectomy for Small Colorectal Polyps - a Prospective Randomized Controlled Trial
Saito Masashi, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki
GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB365-AB366 2017年5月
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Objective Assessment of Jejunal Villous Blood Flow for Evaluating Pancreas-Jejunum Functional Correlation Using a Novel Image Analyzing System
Takeyama Tomoaki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kawai Manabu, Suhara Hiroki, Hashizume Kiyotaka, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi
GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB319-AB320 2017年5月
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Novel EMR Technique for Preoperative Diagnosis and Treatment of Submucosal Tumor in the Small Bowel at Double-Balloon Endoscopy
Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki
GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB300-AB300 2017年5月
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Clinical Factors Related to False Positive Rates of Patency Capsule Examination
Sawada Tsunaki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Goto Hidemi, Hirooka Yoshiki
GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB305-AB305 2017年5月
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An Unusual Case of Pancreatic Metastasis from Squamous Cell Carcinoma of the Lung Diagnosed by EUS-Guided Fine Needle Biopsy.
Ishikawa T, Hirooka Y, Teman CJ, Goto H, Belletrutti PJ
Case reports in gastrointestinal medicine 2017 巻 頁： 3212056 2017年
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[Risk factors for rebleeding and risk-based follow-up of obscure gastrointestinal bleeding after its initial diagnosis].
Uchida G, Nakamura M, Watanabe O, Yamamura T, Matsushita M, Ishikawa T, Furukawa K, Funasaka K, Ohno E, Kawashima H, Miyahara R, Goto H, Hirooka Y
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 114 巻 ( 10 ) 頁： 1819 - 1829 2017年
科研費 5
-
膵癌早期診断を目的とした、IPMNの病変及び周囲背景膵における遺伝子変異解析
研究課題/研究課題番号：22K08010 2022年4月 - 2025年3月
科学研究費助成事業 基盤研究(C)
大野 栄三郎, 石川 卓哉, 加藤 あす香, 川嶋 啓揮, 西田 一貴, 飯田 忠, 水谷 泰之
担当区分：研究分担者
膵癌早期診断は喫緊の課題であるが、未だに高リスク群の絞り込みは不十分である。膵管内乳頭粘液性腫瘍(IPMN)は自身の悪性化に加え、通常型膵癌が高頻度に発生すると報告されている。本研究では、サーベイランス中の膵嚢胞症例中、手術例(膵癌または悪性IPMN疑い)における、切除病変の遺伝子変異プロファイルと周囲正常膵実質内の膵管上皮内腫瘍性病変(PanIN)の発症頻度および背景膵実質内膵管上皮における遺伝子変異プロファイルを同時に解析し、IPMN症例における膵管癌発生の超高リスク群の特徴を解明する。更にその結果を蓄積された臨床情報、画像情報、血液検体と対比し、膵発癌予測の新規バイオマーカーを探索する。
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胆膵疾患の十二指腸主乳頭擦過採取による表在細菌叢プロファイル作成と臨床応用の探索
研究課題/研究課題番号：21K19897 2021年7月 - 2024年3月
科学研究費助成事業 挑戦的研究(萌芽)
川嶋 啓揮, 大野 栄三郎, 石川 卓哉, 飯田 忠, 中村 正直
担当区分：研究分担者
本研究の目的は、胆膵疾患の十二指腸主乳頭（PV）のブラシ擦過採取による表層細菌叢プロファイル作成と将来の基礎研究・臨床応用の可能性を探索することである。Fusobacterium nucleatumと大腸癌の関連が報告され、膵癌についても腫瘍内細菌の存在が明らかとなり注目されている。しかし、膵癌以外の胆膵疾患に関する報告は乏しい。PVは胆管・膵管が開口し、病変を通過した胆汁・膵液にさらされており、直視下に低侵襲でサンプル採取出来る特徴をもつ。本研究はPV擦過採取による細菌叢解析を行い今後の胆膵疾患の表層細菌叢、手術検体による病変内細菌叢、PV表層細菌叢と臨床所見を比較検討できるかを探索する。
本研究の目的は、胆膵疾患の十二指腸主乳頭（PV）のブラシ擦過採取による表層細菌叢プロファイル作成と将来の基礎研究・臨床応用の可能性を探索することである。膵癌についても腫瘍内細菌の存在が明らかとなり注目されている。しかし、膵癌以外の胆膵疾患に関する報告は乏しい。PVは胆管・膵管が開口し、病変を通過した胆汁・膵液にさらされており、直視下に低侵襲でサンプル採取出来る特徴をもつ。本研究はPV擦過採取による細菌叢解析を行い今後の胆膵疾患の表層細菌叢、手術検体による病変内細菌叢、PV表層細菌叢と臨床所見を比較検討できるかを探索する。
2021年度で乳頭部腺腫11例、乳頭部癌6例、胆管癌14例に同意を取得し、サンプル採取を行った。乳頭部癌と腺腫では菌種に有意差が認められ、一部、大腸がんなど他の癌での増加が指摘されている菌種の増加が指摘され、α多様性にも有意差が認められた。胆管癌症例の乳頭部擦過による菌叢解析は可能であるが、胆管病変部のNGS解析可能率が50％を下回っており採取方法に工夫が必要だと考えられた。この結果により少なくとも、PVと胆管病変表層には細菌叢が存在しており、PVにおいては腺癌症例の菌種が有意に異なることが分かった。
2022年度は、特に胆管病変の症例数を増やすとともに、解析率を改善できる取り組みも考慮する。乳頭部腺腫、腺癌症例については当院で施行している大腸腫瘍症例との比較検討を行うとともに、発癌メカニズムの解析につながるような基礎的発展研究の可能性も模索したい。
症例数の蓄積は順調に進んでいる。PVと胆管病変表層には細菌叢が存在していることが分かり、解析も可能であり今後の研究の継続に期待が持てる。乳頭部腺腫、乳頭部腺癌症例では予想されていた菌種の増加が認められた。名古屋大学医学部附属病院消化器内科で施行している大腸腫瘍の研究との差異を見出しながら、症例数を増やすとともに、発癌メカニズムの解析など基礎的検討も考慮できる状況である。胆管病変部の解析率の改善に向けて原因検索を行っている状態であるが、症例数は増えているので解析数はまずまずの数字になっている。
乳頭部腫瘍については大腸や他の消化器疾患における細菌叢との比較なども考慮していく。胆管病変については、まず多くの症例をエントリーして解析可能な症例数を増やすとともに採取方法の改善を模索する。摘出標本での擦過や組織採取も進めていきたい。 -
免疫チェックポイント阻害剤抵抗性を改善する革新的膵癌治療法の開発
研究課題/研究課題番号：21K07941 2021年4月 - 2024年3月
科学研究費助成事業 基盤研究(C)
飯田 忠, 大野 栄三郎, 石川 卓哉, 川嶋 啓揮, 藤城 光弘
担当区分：研究分担者
膵がんに代表される難治がんは免疫チェックポイント阻害剤（以下ICI）に対して抵抗性であり、その原因としてCAFが重要な役割を担っている。近年の研究によりCAFを促進性から抑制性にリプログラム（CAF初期化）させることで抵抗性が改善される可能性が示唆されているがその有効性に関しては明らかとなっていない。我々はMeflinを指標とすることでCAF初期化薬の候補薬を既に同定しており、本研究ではこれらの薬剤とICIとの併用効果を検証し、間質をターゲットとした革新的新規治療法の確立を目指す。
本研究ではAM80と免疫チェックポイント阻害剤との併用による腫瘍縮小効果の検証、非臨床検体を用いたAM80による免疫プロファイルの変化と作用機序の解明、さらには臨床検体を用いたAM80による免疫プロファイルの変化の検証を行う予定である。本年度はMeflinの発現量を上昇させる薬剤としてAM80を同定し、抗がん剤とAM80の併用において抗がん剤単剤投与群に比べ優位な縮小効果が得られることを確認し論文化（Iida T et al ,Oncogene,2022）を行った。このデータを基礎にして現在切除不能膵癌に対するAM80とゲムシタビン/ナブパクリタキセルの併用療法に関する治験を計画しプロトコール論文も作成している（Mizutani Y,Iida T et al ,BMC Cancer,2022）。治験は今年度より開始されており、今後臨床検体も得られる予定である（PMDA受付番号：2021-2196）。さらに膵癌細胞株（ｍT5）を用いICIとAM80の併用したところ、ICI単剤群と比べ優位な腫瘍縮小効果を確認することができている。引き続き他の膵癌細胞株、他のモデルマウスをを用いて検証を行っているところである。また、一細胞解析ではAM80非投与群と比べAM80投与群では癌関連線維芽細胞以外の細胞でも様々な変化が認められている。同時に条件をいくつか変えた腫瘍をRNAseqに提出しており一細胞解析の結果と比較検討する予定でいる。この検証は癌関連線維芽細胞との関連性を含めさらなるメカニズムの解明につながる可能性があり当初の計画通り実験は進んでいると考えている。
計画通り順調に進んでいるため。
今後の研究の中心はAM80投与群の免疫プロファイルの検証に移る予定である。AM80による免疫細胞への直接的な作用も考えられるが、癌関連線維芽細胞を中心としたメカニズムの解明へとつながるかどうかも含めメフリン欠失マウス等を用い検証する予定である。 -
膵疾患に対する超音波内視鏡検査の診断能向上を目的とした人工知能の臨床応用
研究課題/研究課題番号：20K12689 2020年4月 - 2023年3月
科学研究費助成事業 基盤研究(C)
石川 卓哉, 大野 栄三郎, 川嶋 啓揮, 藤城 光弘
担当区分：研究代表者
配分額：3510000円 （ 直接経費：2700000円 、 間接経費：810000円 ）
膵癌は早期発見が困難な上に進行が早く、極めて予後不良である。超音波内視鏡検査（EUS）は体の表面からの超音波検査と違って消化管の空気や脂肪などの影響を受けにくく、小さな膵癌の診断にも有用とされる。近年では超音波用造影剤を組みあわせることで血行動態などさらに詳細な評価も可能となった。しかし、EUSは検査の特性上主観性が高く、術者の技量や経験によるところが大きい。一方、消化器内視鏡画像を用いた人工知能（AI）診断の有用性が報告されており、EUSの分野でも応用が期待される。本研究では、EUSで得られた画像をAIに機械学習させることで術者の技量や経験の差を軽減し、膵癌診断における新たな診断体系の確立を目指す。
膵癌の予後改善のためには早期発見と適切な診断が必須である。画像診断技術の進歩により、膵臓の小腫瘤性病変が発見されるようになってきたが、良悪性診断は容易ではない。研究代表者らはこれまでに膵腫瘤の診断における、EUSに超音波用造影剤を組み合わせた造影EUSの有用性について報告してきた。しかし、EUSは主観性が高く、術者の技量や経験によるところも大きい。本研究では、造影EUSで得られた画像を人工知能（AI）に機械学習させることで術者の技量や経験の差を軽減し、膵腫瘤診断における新たな診断体系の確立を目的とした。
現在までに膵癌58例、非膵癌61例の合計119例の画像データを集積し、研究協力者である名城大学電気電子工学科の力を借りて機械学習による解析を行った。機械学習には、Attentionを使用したV-Netという手法を用いて学習・検証・テストを行った。3回の交差検証による膵癌・非膵癌の自動診断の感度、特異度、正診率の平均は、それぞれ83.3%、88.9%、86%であった。今後Attentionで重要視する領域を再分析、改善させることで、さらなる診断能向上が期待される。
令和3年度は膵病変に対するEUSガイド下穿刺生検(EUS-FNB)におけるAIの有用性についても検討を行った。膵疾患に対して22Gフランシーン形状針を用いてEUS-FNBを施行し、検体採取直後に実体顕微鏡で撮影を行った96例173検体を対象とし、機械学習の一つである対照学習を用いた、膵疾患におけるEUS-FNB検体の新たな評価法の開発を目的とした。対照学習を用いた8分割交差検証（学習13時間、推論11分）による自動診断の感度、特異度、正診率の平均は、それぞれ90.34%、53.5%、84.39%であり、EUS熟練者による肉眼的判定と同等、もしくはそれ以上の診断能を得た。
造影EUSの症例数としては当初の目標であった膵癌、非膵癌合計100例に対し、合計119例の症例を集積できた。
また、膵臓に対する造影EUS以外の検討として、EUSガイド下穿刺生検（EUS-FNB）における人工知能（AI）の有用性についても症例の集積、研究をすすめることができた。
機械学習による解析についても名城大学電気電子工学科の協力のもと、解析をすすめており、概ね順調に進展していると考えている。
AIを用いた造影EUSによる膵腫瘤性病変に対する良悪性診断能の検討については、解析結果を令和3年4月に日本消化器病学会総会で発表した。今後さらに症例を集積し、論文化を目指す。
EUSガイド下穿刺生検（EUS-FNB）で得られた検体の実体顕微鏡写真に基づく機械学習による解析結果については、令和3年9月に日本膵臓学会大会にてdeep learningを用いた解析結果について発表した。この結果を踏まえ、deep learningに加えて機械学習の手法である対照学習を用いた解析結果を令和4年5月に日本消化器内視鏡学会総会で発表する予定である。 -
超音波内視鏡下エラストグラフィによる組織硬度測定による膵癌の臨床病理学的病態解析
研究課題/研究課題番号：18K12054 2018年4月 - 2021年3月
科学研究費助成事業 基盤研究(C)
大野 栄三郎, 川嶋 啓揮, 廣岡 芳樹, 宮原 良二, 中村 正直, 石川 卓哉
担当区分：研究分担者
本研究課題では膵癌における「硬度」情報測定方法の確立及び「硬度」と膵癌の生物学的悪性度、分子生物学的特徴との関連を解明すべく研究を行った。新規硬度測定ツールであるEUS-shear wave elastographyは硬度計測に不安定性を示し、組織硬度評価にはヒストグラム解析を付加したStrain法が膵腫瘍硬度評価に安定した結果を示し、膵腫瘍の種類別に硬度が層別化されることを示した。膵癌の臨床病理学的特徴と硬度との関連では、高硬度の膵癌は切除後予後が有意に不良であることが示され、非切除例では抗がん剤治療の奏効期間と相関を認めた。現在組織硬度に関連する癌組織、CAFの遺伝子変異を解析中である。
最新の膵癌治療戦略において、近年ではCAFをターゲットとして、膵癌関連間質の特徴を変化させることにより抗がん剤のドラッグデリバリを改善をはじめとして化学療法の奏功率を向上させる試みが行われている。膵癌組織に対して癌線維性間質を組織学的所見以外で正確に評価する腫瘍は確立していない。本研究結果ではEUSエラストグラフィを用いた組織硬度計測の不安定性の課題が残るため、より正確な組織硬度計測手法の開発が期待される。本研究課題の結果成果は膵癌病態解明及び膵癌に対する新規治療開発の基礎となることが期待される。