Updated on 2025/03/19

写真a

 
ISHIKAWA Takuya
 
Organization
Nagoya University Hospital Gastroenterology Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 2

  1. Doctor of Philosophy ( 2011.3   Nagoya University ) 

  2. Doctor of Medicine ( 2001.3   Nagoya University ) 

Research Areas 1

  1. Life Science / Gastroenterology  / Gastroenterology and Hepatology

Current Research Project and SDGs 2

  1. Clinical application of artificial intelligence to improve the diagnostic performance of ultrasound endoscopy for pancreatic diseases

  2. 膵がんにおける組織採取法の最適化と線維芽細胞の多様性に基づく個別化医療の開発

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    2007.4 - 2011.3

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    Country: Japan

  2. Nagoya University   School of Medicine

    1995.4 - 2001.3

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    Country: Japan

Awards 4

  1. 日本胆道学会賞

    2024.10   日本胆道学会   1型自己免疫性膵炎に合併する胆管病変の狭窄部位からみた臨床像と長期予後

    石川卓哉

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  2. The Best Video Abstract Runner Up

    2023.12   APDW 2023   EUS-guided drainage using a forward-viewing echoendoscope for peripancreatic fluid collection associated with pancreatic jejunal anastomosis

    Takuya Ishikawa

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    Award type:Award from international society, conference, symposium, etc.  Country:Thailand

  3. Best Abstract Award 2020

    2020.3   ENDO 2020/JGES   EUS elastography combined with the strain ratio in the estimation of short-term treatment effect in autoimmune pancreatitis

    Takuya Ishikawa

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    Award type:Award from international society, conference, symposium, etc.  Country:Brazil

  4. 日本胆道学会賞

    2012.10   日本胆道学会   悪性黒色腫胆嚢転移の1例

    石川卓哉

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    Country:Japan

 

Papers 195

  1. Endoscopic transpapillary gallbladder drainage using a novel sphincterotome

    Ishikawa, T; Kumano, R; Kawashima, H

    DIGESTIVE ENDOSCOPY   Vol. 37 ( 3 ) page: 297 - 299   2025.3

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  2. Usefulness of endoscopic ultrasonography for differentiating between non-functional pancreatic neuroendocrine neoplasm and intrapancreatic accessory spleen.

    Kano Y, Ishikawa T, Yamao K, Mizutani Y, Iida T, Uetsuki K, Yamamura T, Furukawa K, Nakamura M, Kawashima H

    Scientific reports   Vol. 15 ( 1 ) page: 6385   2025.2

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    Language:English  

    DOI: 10.1038/s41598-025-91272-w

    PubMed

  3. Prognostic Role of Enhancing Mural Nodules in Intraductal Papillary Mucinous Neoplasms with High-Risk Stigmata.

    Kumano R, Ohno E, Ishikawa T, Yamao K, Mizutani Y, Iida T, Uetsuki K, Yamamura T, Furukawa K, Nakamura M, Honda T, Kawashima H

    Annals of surgery     2025.2

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    Language:English  

    DOI: 10.1097/SLA.0000000000006674

    PubMed

  4. A case of pancreatic fistula with disruption of the inferior branch of the pancreatic duct caused by a pancreatic stent after endoscopic papillectomy.

    Takada Y, Ishikawa T, Yamao K, Mizutani Y, Iida T, Uetsuki K, Kawashima H

    Clinical journal of gastroenterology   Vol. 18 ( 1 ) page: 169 - 175   2025.2

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    DOI: 10.1007/s12328-024-02067-x

    PubMed

  5. Clinical features and pathological findings by liver biopsy in patients with immune-related sclerosing cholangitis induced by immune checkpoint inhibitors.

    Yasuda T, Ito T, Ishikawa T, Mizuno K, Yamamoto T, Yokoyama S, Yamamoto K, Imai N, Ishizu Y, Honda T, Koshiyama Y, Yasuda S, Toyoda H, Ando Y, Shimoyama Y, Kawashima H

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     2025.1

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    DOI: 10.1016/j.dld.2025.01.037

    PubMed

  6. Endoscopic ultrasound-guided drainage using a forward-viewing echoendoscope for peripancreatic fluid collection after Child resection

    Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Uetsuki, K; Nakamura, M; Kawashima, H

    ENDOSCOPY   Vol. 56 ( S 01 ) page: E83 - E84   2024.12

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  7. New drug-delivery balloon catheter for easy and fast injection of triamcinolone after esophageal endoscopic submucosal dissection

    Hirose, T; Shibata, H; Furukawa, K; Yamamura, T; Ishikawa, T; Nakamura, M; Kawashima, H

    ENDOSCOPY   Vol. 56 ( S 01 ) page: E634 - E635   2024.12

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  8. Clinical factors influencing patency capsule excretion and confirmation in patients with intestinal patency.

    Ikegami S, Yamamura T, Nakamura M, Maeda K, Sawada T, Ishikawa E, Ishikawa T, Furukawa K, Hirose T, Kawashima H

    Revista espanola de enfermedades digestivas     2024.11

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    DOI: 10.17235/reed.2024.10706/2024

    PubMed

  9. A newly proposed endoscopic score system to evaluate the entire small bowel and predict the prognosis in Crohn's disease.

    Tanaka H, Nakamura M, Yamamura T, Maeda K, Sawada T, Ishikawa E, Hirose T, Uetsuki K, Iida T, Mizutani Y, Yamao K, Ishikawa T, Ishizu Y, Furukawa K, Honda T, Uchida G, Kawashima H

    Nagoya journal of medical science   Vol. 86 ( 4 ) page: 608 - 619   2024.11

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    DOI: 10.18999/nagjms.86.4.608

    PubMed

  10. Risk factors for recurrent biliary obstruction following suprapapillary placement of a plastic stent as preoperative biliary drainage for perihilar biliary malignancy

    Kataoka, K; Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Uetsuki, K; Onoe, S; Mizuno, T; Ebata, T; Kawashima, H

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 31 ( 10 ) page: 726 - 736   2024.10

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  11. Endoscopic Papillectomy for Ampullary Gangliocytic Paraganglioma: A Case Series and Literature Review

    Takada, Y; Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Uetsuki, K; Nakamura, M; Furukawa, K; Yamamura, T; Kawashima, H

    INTERNAL MEDICINE     2024.9

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  12. Diagnosis of isolated hilar-/extrahepatic-type IgG-4-related sclerosing cholangitis can be increased by improved recognition of this condition-A Japanese multicenter analysis

    Kubota, K; Iwasaki, E; Ishikawa, T; Kuwatani, M; Takenaka, M; Iwashita, T; Masuda, A; Ikeura, T; Nakamura, A; Tanaka, A; Isayama, H; Hirooka, Y; Hirano, K; Ryozawa, S; Ogura, T; Fujisawa, T; Kurita, Y; Kikuta, K; Hayashi, N; Masamune, A; Yasuda, I

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 31 ( 9 ) page: 647 - 657   2024.9

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  13. Gastrointestinal: Pancreatic intra-epithelial neoplasia from partial parenchymal atrophy

    Yamao, K; Ishikawa, T; Mizutani, Y; Iida, T; Uetsuki, K; Kawashima, H

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 39 ( 9 ) page: 1711 - 1712   2024.9

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  14. Long-Term Monitoring and Clinical Implications of Small Bowel Capsule Endoscopy in Patients with Crohn's Disease with Small Bowel Lesions: A Retrospective Analysis

    Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Murate, K; Furukawa, K; Hirose, T; Uetsuki, K; Iida, T; Mizutani, Y; Yamao, K; Ishizu, Y; Ishikawa, T; Honda, T; Kawashima, H

    DIGESTION   Vol. 105 ( 5 ) page: 380 - 388   2024.9

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  15. A prospective study on the histological evaluation of type 1 autoimmune pancreatitis using endoscopic ultrasound-guided fine needle biopsy with a 19-gauge Franseen needle

    Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Uetsuki, K; Shimoyama, Y; Nakamura, M; Furukawa, K; Yamamura, T; Kawashima, H

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 31 ( 8 ) page: 581 - 590   2024.8

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  16. Predictors of the efficacy of vedolizumab in patients with ulcerative colitis

    Kajikawa, G; Sawada, T; Nakamura, M; Yamamura, T; Maeda, K; Ishikawa, E; Uetsuki, K; Hirose, T; Iida, T; Mizutani, Y; Yamao, K; Ishikawa, T; Furukawa, K; Kawashima, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 86 ( 3 ) page: 407 - 421   2024.8

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  17. Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade

    Owaki, T; Iida, T; Miyai, Y; Kato, K; Hase, T; Ishii, M; Ando, R; Hinohara, K; Akashi, T; Mizutani, Y; Ishikawa, T; Mii, S; Shiraki, Y; Esaki, N; Yamamoto, M; Tsukamoto, T; Nomura, S; Murakami, T; Takahashi, M; Yuguchi, Y; Maeda, M; Sano, T; Sassa, N; Matsukawa, Y; Kawashima, H; Akamatsu, S; Enomoto, A

    BRITISH JOURNAL OF CANCER   Vol. 131 ( 2 ) page: 372 - 386   2024.7

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  18. Cutting edge of endoscopic ultrasound-guided fine-needle aspiration for solid pancreatic lesions (NOV, 10.1007/s10396-023-01375-y, 2023)

    Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Kawashima, H

    JOURNAL OF MEDICAL ULTRASONICS   Vol. 51 ( 3 ) page: 539 - 539   2024.7

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  19. What is the appropriate method of pathological specimen collection for cholangiocarcinoma detection in primary sclerosing cholangitis?

    Kano, Y; Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Uetsuki, K; Yamamura, T; Furukawa, K; Nakamura, M; Kawashima, H

    JOURNAL OF GASTROENTEROLOGY   Vol. 59 ( 7 ) page: 621 - 628   2024.7

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  20. Cutting edge of endoscopic ultrasound-guided fine-needle aspiration for solid pancreatic lesions

    Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Kawashima, H

    JOURNAL OF MEDICAL ULTRASONICS   Vol. 51 ( 2 ) page: 209 - 217   2024.4

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  21. An atypical case of isolated immunoglobulin G4-related sclerosing cholangitis with a cholangiogram resembling primary sclerosing cholangitis

    Takada, Y; Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Uetsuki, K; Kawashima, H

    CLINICAL JOURNAL OF GASTROENTEROLOGY   Vol. 17 ( 2 ) page: 338 - 344   2024.4

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  22. Artificial intelligence in a prediction model for postendoscopic retrograde cholangiopancreatography pancreatitis

    Takahashi, H; Ohno, E; Furukawa, T; Yamao, K; Ishikawa, T; Mizutani, Y; Iida, T; Shiratori, Y; Oyama, S; Koyama, J; Mori, K; Hayashi, Y; Oda, M; Suzuki, T; Kawashima, H

    DIGESTIVE ENDOSCOPY   Vol. 36 ( 4 ) page: 463 - 472   2024.4

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  23. Outcomes of endoscopic papillectomy of ampullary carcinoma and factors affecting additional surgery

    Takada, Y; Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Uetsuki, K; Gibo, N; Ohno, E; Kawashima, H

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 31 ( 2 ) page: 110 - 119   2024.2

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  24. Risk factors for rebleeding in gastroduodenal ulcers

    Ito, N; Funasaka, K; Fujiyoshi, T; Nishida, K; Satta, Y; Furukawa, K; Kakushima, N; Furune, S; Ishikawa, E; Mizutani, Y; Sawada, T; Maeda, K; Ishikawa, T; Yamamura, T; Ohno, E; Nakamura, M; Miyahara, R; Sasaki, Y; Haruta, JI; Fujishiro, M; Kawashima, H

    IRISH JOURNAL OF MEDICAL SCIENCE   Vol. 193 ( 1 ) page: 173 - 179   2024.2

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  25. Impact of sarcopenia on biliary drainage during neoadjuvant therapy for pancreatic cancer

    Kataoka, K; Ohno, E; Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Takami, H; Maeda, O; Yamaguchi, J; Yokoyama, Y; Ebata, T; Kodera, Y; Kawashima, H

    CLINICAL ENDOSCOPY   Vol. 57 ( 1 ) page: 112 - 121   2024.1

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  26. DeformableFormer for Classification of the Presence or Absence of Pancreatic Tissue Fragments in Pancreatic Disease

    Kurami, T; Ishikawa, T; Hotta, K

    IEEE ACCESS   Vol. 12   page: 122503 - 122512   2024

  27. Analysis of Neuropeptides in the Intestinal Mucus of Patients with Ulcerative Colitis Using RNA Sequencing.

    Nakamura M, Murate K, Maeda K, Yamamura T, Sawada T, Ishikawa E, Furukawa K, Hirose T, Uetsuki K, Iida T, Mizutani Y, Yamao K, Ishizu Y, Ishikawa T, Honda T, Kawashima H

    Digestion   Vol. 105 ( 5 ) page: 400 - 410   2024

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    Language:English  

    DOI: 10.1159/000540052

    PubMed

  28. [Current status of diagnosis and drainage in biliary stenosis lesions].

    Kawashima H, Ishikawa T, Yamao K

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   Vol. 121 ( 4 ) page: 251 - 257   2024

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    DOI: 10.11405/nisshoshi.121.251

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  29. Current status of and future issues related to endoscopic papillectomy

    Kawashima, H; Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Uetsuki, K; Yamamura, T; Furukawa, K; Nakamura, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 4 ) page: 648 - 658   2023.11

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  30. Real-World Effectiveness and Risk Factors for Discontinuation of Ustekinumab in Ulcerative Colitis.

    Uchida G, Nakamura M, Yamamura T, Maeda K, Sawada T, Ishikawa E, Furukawa K, Iida T, Mizutani Y, Yamao K, Ishikawa T, Ishizu Y, Honda T, Ishigami M, Kawashima H

    Inflammatory intestinal diseases   Vol. 8 ( 2 ) page: 60 - 68   2023.10

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    DOI: 10.1159/000531497

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  31. Randomized trial comparing 15 <i>vs</i> 5 actuations per pass during endoscopic ultrasound-guided fine-needle biopsy for specimen acquisition of solid pancreatic lesions

    Kataoka, K; Ishikawa, T; Ohno, E; Yamao, K; Mizutani, Y; Iida, T; Kato, K; Kinoshita, F; Yamamura, T; Furukawa, K; Nakamura, M; Kawashima, H

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 38 ( 9 ) page: 1647 - 1655   2023.9

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  32. Clinical characteristics of Dieulafoy's lesion in the small bowel diagnosed and treated by double-balloon endoscopy

    Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Furukawa, K; Iida, T; Mizutani, Y; Yamao, K; Ishikawa, T; Honda, T; Ishigami, M; Kawashima, H

    BMC GASTROENTEROLOGY   Vol. 23 ( 1 ) page: 290   2023.8

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  33. Diagnostic Performance of Endocytoscopy for Esophageal Eosinophilia

    Hida, E; Muroi, K; Kakushima, N; Furune, S; Ishikawa, E; Mizutani, Y; Sawada, T; Keiko, M; Yamamura, T; Ishikawa, T; Furukawa, K; Ohno, E; Nakamura, M; Nishida, K; Fujishiro, M; Kawashima, H

    DIGESTION   Vol. 104 ( 3 ) page: 202 - 211   2023.6

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  34. Efficacy of 1-kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double-blind, placebo-controlled pilot study

    Ikegami, S; Nakamura, M; Honda, T; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Yamamoto, K; Furune, S; Ishikawa, T; Furukawa, K; Ohno, E; Ishigami, M; Kinoshita, F; Kadota, Y; Tochio, T; Shimomura, Y; Hirooka, Y; Kawashima, H

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   Vol. 57 ( 11 ) page: 1249 - 1257   2023.6

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  35. ENDOSCOPIC TREATMENT OF DUODENAL NEUROENDOCRINE TUMORS

    Furukawa, K; Furune, S; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Nakamura, M; Kawashima, H

    GASTROINTESTINAL ENDOSCOPY   Vol. 97 ( 6 ) page: AB1211 - AB1212   2023.6

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  36. Abdominal pain accompanied by elevated serum inflammatory markers and biliary enzymes for diagnosing immune checkpoint inhibitor-induced sclerosing cholangitis

    Yamamoto, T; Mizuno, K; Ito, T; Yokoyama, S; Yamamoto, K; Imai, N; Ishizu, Y; Honda, T; Ishikawa, T; Kanamori, A; Yasuda, S; Toyoda, H; Yokota, K; Hase, T; Nishio, N; Maeda, O; Ishii, M; Sone, M; Ando, Y; Akiyama, M; Ishigami, M; Kawashima, H

    INVESTIGATIONAL NEW DRUGS   Vol. 41 ( 3 ) page: 512 - 521   2023.6

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  37. CO<sub>2</sub> enterography in endoscopic retrograde cholangiography using double-balloon endoscopy: A randomized clinical trial

    Murate, K; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Kida, Y; Esaki, M; Hamazaki, M; Iida, T; Mizutani, Y; Yamao, K; Ishikawa, T; Furukawa, K; Ohno, E; Honda, T; Ishigami, M; Kinoshita, F; Ando, M; Kawashima, H

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 38 ( 5 ) page: 761 - 767   2023.5

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  38. Accuracy of Serum Leucine-Rich Alpha-2 Glycoprotein in Evaluating Endoscopic Disease Activity in Crohn's Disease

    Kawamura, T; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Ishikawa, E; Iida, T; Mizutani, Y; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M

    INFLAMMATORY BOWEL DISEASES   Vol. 29 ( 2 ) page: 245 - 253   2023.2

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  39. Current Status of the Diagnosis of Early-Stage Pancreatic Ductal Adenocarcinoma

    Nakaoka, K; Ohno, E; Kawabe, N; Kuzuya, T; Funasaka, K; Nakagawa, Y; Nagasaka, M; Ishikawa, T; Watanabe, A; Tochio, T; Miyahara, R; Shibata, T; Kawashima, H; Hashimoto, S; Hirooka, Y

    DIAGNOSTICS   Vol. 13 ( 2 )   2023.1

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  40. Factors Related to Delayed Adverse Events of Endoscopic Submucosal Dissection in the Duodenum Reviewed

    Kawamura, T; Hirose, T; Kakushima, N; Furukawa, K; Furune, S; Ishikawa, E; Sawada, T; Keiko, M; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Honda, T; Ishigami, M; Kawashima, H; Fujishiro, M

    DIGESTIVE DISEASES   Vol. 41 ( 1 ) page: 80 - 88   2023.1

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  41. Network Analysis of Gut Microbiota Including <i>Fusobacterium</i> and Oral Origin Bacteria and Their Distribution on Tumor Surface, Normal Mucosa, and in Feces in Patients with Colorectal Cancer

    Ohashi, A; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Ishikawa, E; Yamamoto, K; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Fujishiro, M

    DIGESTION   Vol. 103 ( 6 ) page: 451 - 461   2022.12

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  42. Analysis of immunologic comorbidities in ulcerative colitis patients: a tool to prevent exacerbations in ulcerative colitis cases

    Meza Miguel Ricardo Rodriguez, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Iida Tadashi, Mizutani Yasuyuki, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 4 ) page: 733 - 745   2022.11

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  43. An improved method to assess skeletal muscle mass in patients with liver cirrhosis based on computed tomography images

    Sugiyama, Y; Ishizu, Y; Ando, Y; Yokoyama, S; Yamamoto, K; Ito, T; Imai, N; Nakamura, M; Honda, T; Kawashima, H; Ishikawa, T; Ishigami, M

    HEPATOLOGY RESEARCH   Vol. 52 ( 11 ) page: 937 - 946   2022.11

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  44. The effects of ustekinumab on small intestinal lesions and stenotic lesions

    Wada, H; Murate, K; Nakamura, M; Furukawa, K; Kakushima, N; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Ishikawa, T; Ohno, E; Honda, T; Kawashima, H; Nakayama, G; Hattori, N; Umeda, S; Ishigami, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 4 ) page: 825 - 838   2022.11

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  45. The role of EUS elastography-guided fine needle biopsy in the histological diagnosis of solid pancreatic lesions: a prospective exploratory study

    Ohno, E; Kawashima, H; Ishikawa, T; Mizutani, Y; Iida, T; Nishio, R; Uetsuki, K; Yashika, J; Yamada, K; Yoshikawa, M; Gibo, N; Aoki, T; Kataoka, K; Mori, H; Takada, Y; Aoi, H; Takahashi, H; Yamamura, T; Furukawa, K; Nakamura, M; Shimoyama, Y; Hirooka, Y; Fujishiro, M

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 16603   2022.10

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  46. Author Correction: Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer.

    Yoshikawa M, Ishikawa T, Ohno E, Iida T, Furukawa K, Nakamura M, Honda T, Ishigami M, Kinoshita F, Kawashima H, Fujishiro M

    Scientific reports   Vol. 12 ( 1 ) page: 16190   2022.9

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    DOI: 10.1038/s41598-022-21219-y

    PubMed

  47. Modified N score is helpful for identifying patients who need endoscopic intervention among those with black stools without hematemesis

    Ito, N; Funasaka, K; Fujiyoshi, T; Furukawa, K; Kakushima, N; Furune, S; Ishikawa, E; Mizutani, Y; Sawada, T; Maeda, K; Ishikawa, T; Yamamura, T; Ohno, E; Nakamura, M; Kawashima, H; Miyahara, R; Hirooka, Y; Haruta, JI; Fujishiro, M

    DIGESTIVE ENDOSCOPY   Vol. 34 ( 6 ) page: 1157 - 1165   2022.9

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  48. Endoscopic management of perihilar cholangiocarcinoma

    Kawashima, H; Ohno, E; Ishikawa, T; Mizutani, Y; Iida, T; Yamamura, T; Kakushima, N; Furukawa, K; Nakamura, M

    DIGESTIVE ENDOSCOPY   Vol. 34 ( 6 ) page: 1147 - 1156   2022.9

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  49. Comparison of outcomes between secondary fully covered and uncovered self-expandable metal stents in the treatment of recurrent biliary obstruction of pancreatic cancer Reviewed

    Kataoka, K; Kawashima, H; Ohno, E; Ishikawa, T; Mizutani, Y; Iida, T; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Fujishiro, M

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 36 ( 8 ) page: 5676 - 5683   2022.8

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  50. Fecal microbiota transplantation in the treatment of irritable bowel syndrome: a single-center prospective study in Japan

    Hamazaki, M; Sawada, T; Yamamura, T; Maeda, K; Mizutani, Y; Ishikawa, E; Furune, S; Yamamoto, K; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Nakamura, M; Fujishiro, M

    BMC GASTROENTEROLOGY   Vol. 22 ( 1 ) page: 342   2022.7

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  51. Comparison of an Inside Stent and a Fully Covered Self-Expandable Metallic Stent as Preoperative Biliary Drainage for Patients with Resectable Perihilar Cholangiocarcinoma

    Mori, H; Kawashima, H; Ohno, E; Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Nakamura, M; Ishigami, M; Onoe, S; Mizuno, T; Ebata, T; Fujishiro, M

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 2022   page: 3005210   2022.7

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  52. Endoscopic sphincterotomy and endoscopic biliary stenting do not affect the sensitivity of transpapillary forceps biopsy for the diagnosis of bile duct adenocarcinoma

    Aoki, T; Ohno, E; Ishikawa, T; Mizutani, Y; Iida, T; Yamao, K; Yamamura, T; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Yatsuya, H; Kawashima, H

    BMC GASTROENTEROLOGY   Vol. 22 ( 1 ) page: 329   2022.7

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  53. Factors associated with misdiagnosis of preoperative endoscopic ultrasound in patients with pancreatic cystic neoplasms undergoing surgical resection

    Ohno, E; Ishikawa, T; Mizutani, Y; Iida, T; Uetsuki, K; Yashika, J; Yamada, K; Gibo, N; Aoki, T; Kawashima, H

    JOURNAL OF MEDICAL ULTRASONICS   Vol. 49 ( 3 ) page: 433 - 441   2022.7

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  54. Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics (Apr, 10.1038/s41388-022-02288-9, 2022)

    Iida, T; Mizutani, Y; Esaki, N; Ponik, SM; Burkel, BM; Weng, L; Kuwata, K; Masamune, A; Ishihara, S; Haga, H; Kataoka, K; Mii, S; Shiraki, Y; Ishikawa, T; Ohno, E; Kawashima, H; Hirooka, Y; Fujishiro, M; Takahashi, M; Enomoto, A

    ONCOGENE   Vol. 41 ( 23 ) page: 3302 - 3302   2022.6

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  55. Results of a Phase II Study on the Use of Neoadjuvant Chemotherapy (FOLFIRINOX or GEM/nab-PTX) for Borderline-resectable Pancreatic Cancer (NUPAT-01) Reviewed

    Yamaguchi, J; Yokoyama, Y; Fujii, T; Yamada, S; Takami, H; Kawashima, H; Ohno, E; Ishikawa, T; Maeda, O; Ogawa, H; Kodera, Y; Nagino, M; Ebata, T

    ANNALS OF SURGERY   Vol. 275 ( 6 ) page: 1043 - 1049   2022.6

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  56. Comparison of contrast-enhanced transabdominal ultrasonography following endoscopic ultrasonography with GD-EOB-DTPA-enhanced MRI for the sequential diagnosis of liver metastasis in patients with pancreatic cancer Reviewed

    Ishikawa, T; Ohno, E; Mizutani, Y; Iida, T; Koya, T; Sasaki, Y; Ogawa, H; Kinoshita, F; Hirooka, Y; Kawashima, H

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 29 ( 6 ) page: 682 - 692   2022.6

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  57. Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics

    Iida, T; Mizutani, Y; Esaki, N; Ponik, SM; Burkel, BM; Weng, L; Kuwata, K; Masamune, A; Ishihara, S; Haga, H; Kataoka, K; Mii, S; Shiraki, Y; Ishikawa, T; Ohno, E; Kawashima, H; Hirooka, Y; Fujishiro, M; Takahashi, M; Enomoto, A

    ONCOGENE   Vol. 41 ( 19 ) page: 2764 - 2777   2022.5

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  58. Effects of steroid use for stenosis prevention after endoscopic submucosal dissection for cervical esophageal cancer Reviewed

    Muroi, K; Kakushima, N; Furukawa, K; Furune, S; Ito, N; Hirose, T; Ishikawa, E; Mizutani, Y; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Funasaka, K; Miyahara, R; Fujishiro, M

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 27 ( 5 ) page: 940 - 947   2022.5

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  59. Gelsolin as a Potential Biomarker for Endoscopic Activity and Mucosal Healing in Ulcerative Colitis

    Maeda, K; Nakamura, M; Yamamura, T; Sawada, T; Ishikawa, E; Oishi, A; Ikegami, S; Kakushima, N; Furukawa, K; Iida, T; Mizutani, Y; Ishikawa, T; Ohno, E; Honda, T; Ishigami, M; Kawashima, H

    BIOMEDICINES   Vol. 10 ( 4 )   2022.4

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  60. Relationship between psoas muscle index and long-term survival in older patients aged ≥ 80 years after endoscopic submucosal dissection for gastric cancer

    Ito, N; Funasaka, K; Miyahara, R; Furukawa, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Hirooka, Y; Fujishiro, M

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 27 ( 4 ) page: 729 - 738   2022.4

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  61. Pancreatic acinar cell carcinoma with predominant extension into the main pancreatic duct: A case report

    Ishikawa, T; Ohno, E; Mizutani, Y; Iida, T; Kawashima, H

    DEN OPEN   Vol. 2 ( 1 ) page: e96   2022.4

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  62. Diagnostic performance of endoscopic classifications for neoplastic lesions in patients with ulcerative colitis: A retrospective case-control study

    Kida, Y; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Mizutani, Y; Kakushima, N; Furukawa, K; Ishikawa, T; Ohno, E; Kawashima, H; Nakamura, M; Ishigami, M; Fujishiro, M

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 28 ( 10 ) page: 1055 - 1066   2022.3

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  63. Fecal incontinence and oral regurgitation during duodenal endoscopic submucosal dissection using the water pressure method Reviewed

    Takada, Y; Hirose, T; Nishida, K; Kakushima, N; Furukawa, K; Furune, S; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Honda, T; Ishigami, M; Kawashima, H; Fujishiro, M

    DIGESTIVE ENDOSCOPY   Vol. 34 ( 3 ) page: 526 - 534   2022.3

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  64. The impact of the age-adjusted Charlson comorbidity index as a prognostic factor for endoscopic papillectomy in ampullary tumors Reviewed

    Takada, Y; Kawashima, H; Ohno, E; Ishikawa, T; Mizutani, Y; Iida, T; Yamamura, T; Kakushima, N; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Ito, A; Hirooka, Y

    JOURNAL OF GASTROENTEROLOGY   Vol. 57 ( 3 ) page: 199 - 207   2022.3

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  65. Artificial intelligence-based diagnosis of upper gastrointestinal subepithelial lesions on endoscopic ultrasonography images Reviewed

    Hirai, K; Kuwahara, T; Furukawa, K; Kakushima, N; Furune, S; Yamamoto, H; Marukawa, T; Asai, H; Matsui, K; Sasaki, Y; Sakai, D; Yamada, K; Nishikawa, T; Hayashi, D; Obayashi, T; Komiyama, T; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Ishigami, M; Fujishiro, M

    GASTRIC CANCER   Vol. 25 ( 2 ) page: 382 - 391   2022.3

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  66. A novel scoring system to predict therapeutic intervention for non-variceal upper gastrointestinal bleeding Reviewed

    Ito, N; Funasaka, K; Furukawa, K; Kakushima, N; Hirose, T; Muroi, K; Suzuki, T; Suzuki, T; Hida, E; Ishikawa, T; Yamamura, T; Ohno, E; Nakamura, M; Kawashima, H; Miyahara, R; Fujishiro, M

    INTERNAL AND EMERGENCY MEDICINE   Vol. 17 ( 2 ) page: 423 - 430   2022.3

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  67. Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma Reviewed

    Mizutani, Y; Iida, T; Ohno, E; Ishikawa, T; Kinoshita, F; Kuwatsuka, Y; Imai, M; Shimizu, S; Tsuruta, T; Enomoto, A; Kawashima, H; Fujishiro, M

    BMC CANCER   Vol. 22 ( 1 ) page: 205   2022.2

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  68. Initial experience of tofacitinib for treating refractory moderate-to-severe ulcerative colitis Reviewed

    Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Kawashima, H; Honda, T; Ishigami, M; Fujishiro, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 1 ) page: 169 - 179   2022.2

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  69. Development of a Novel Evaluation Method for Endoscopic Ultrasound-Guided Fine-Needle Biopsy in Pancreatic Diseases Using Artificial Intelligence Reviewed

    Ishikawa, T; Hayakawa, M; Suzuki, H; Ohno, E; Mizutani, Y; Iida, T; Fujishiro, M; Kawashima, H; Hotta, K

    DIAGNOSTICS   Vol. 12 ( 2 )   2022.2

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  70. Usefulness of Macroscopic On-Site Evaluation Using a Stereomicroscope during EUS-FNB for Diagnosing Solid Pancreatic Lesions Reviewed

    Ishikawa, T; Ohno, E; Mizutani, Y; Iida, T; Uetsuki, K; Yashika, J; Yamada, K; Gibo, N; Aoki, T; Kataoka, K; Mori, H; Takada, Y; Takahashi, H; Aoi, H; Kato, K; Yamamura, T; Kakushima, N; Furukawa, K; Nakamura, M; Hirooka, Y; Kawashima, H

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 2022   page: 2737578   2022.1

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  71. Fish bone migration after pancreaticoduodenectomy: Incidence and treatment options Reviewed

    Takada, Y; Ishikawa, T; Kawashima, H; Mizutani, Y; Ohno, E; Iida, T; Ogawa, H; Hayashi, M; Takami, H; Onoe, S; Ishigami, M

    JOURNAL OF DIGESTIVE DISEASES   Vol. 23 ( 1 ) page: 44 - 49   2022.1

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  72. Evaluation of ulcerative colitis activity using transabdominal ultrasound shear wave elastography Reviewed

    Yamada, K; Ishikawa, T; Kawashima, H; Ohno, E; Iida, T; Ishikawa, E; Mizutani, Y; Sawada, T; Maeda, K; Yamamura, T; Kakushima, N; Furukawa, K; Nakamura, M; Ishigami, M; Fujishiro, M

    QUANTITATIVE IMAGING IN MEDICINE AND SURGERY   Vol. 12 ( 1 ) page: 618 - 626   2022.1

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  73. Current status of the diagnosis of chronic pancreatitis by ultrasonographic elastography Reviewed

    Nakaoka, K; Hashimoto, S; Miyahara, R; Kawashima, H; Ohno, E; Ishikawa, T; Kuwahara, T; Tanaka, H; Hirooka, Y

    KOREAN JOURNAL OF INTERNAL MEDICINE   Vol. 37 ( 1 ) page: 27 - 36   2022.1

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  74. Differentiation Between Solid Pseudopapillary Neoplasm of the Pancreas and Nonfunctional Pancreatic Neuroendocrine Neoplasm Using Endoscopic Ultrasound Reviewed

    Kataoka, K; Ishikawa, T; Ohno, E; Mizutani, Y; Iida, T; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Kawashima, H; Hirooka, Y; Fujishiro, M

    PANCREAS   Vol. 51 ( 1 ) page: 106 - 111   2022.1

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  75. [Leptomeningeal carcinomatosis from duodenal papillary carcinoma].

    Yamada K, Ohno E, Ishikawa T, Mizutani Y, Iida T, Uetsuki K, Yashika J, Aoki T, Mori H, Kawashima H

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   Vol. 119 ( 11 ) page: 1043 - 1047   2022

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    Language:Japanese  

    DOI: 10.11405/nisshoshi.119.1043

    PubMed

  76. A Microfluidic Device with Check Valves to Detect Cancer using <i>Caenorhabditis elegans</i>

    Shiga, H; Takeuchi, M; Kim, E; Hisamoto, N; Ishikawa, T; Fukuda, T

    2022 IEEE/SICE INTERNATIONAL SYMPOSIUM ON SYSTEM INTEGRATION (SII 2022)     page: 969 - 970   2022

  77. Comparison of Endoscopic Ultrasonography and Conventional Endoscopy for Prediction of Tumor Depth in Superficial Nonampullary Duodenal Epithelial Tumors

    Matsuda, N; Hirose, T; Kakushima, N; Furukawa, K; Furune, S; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Honda, T; Ishigami, M; Kawashima, H; Fujishiro, M

    DIGESTION   Vol. 103 ( 4 ) page: 319 - 328   2022

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  78. Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients Reviewed

    Nakamura, M; Maeda, K; Yamamoto, K; Yamamura, T; Sawada, T; Ishikawa, E; Kakushima, N; Furukawa, K; Iida, T; Mizutani, Y; Ishikawa, T; Ohno, E; Honda, T; Ishigami, M; Kawashima, H

    DIGESTION   Vol. 103 ( 3 ) page: 232 - 243   2022

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  79. Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching Reviewed

    Saito, M; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Ishikawa, E; Mizutani, Y; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Kawashima, H; Ishigami, M; Fujishiro, M

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 27 ( 47 ) page: 8182 - 8193   2021.12

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  80. Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival Reviewed

    Yamada, K; Sawada, T; Nakamura, M; Yamamura, T; Maeda, K; Ishikawa, E; Iida, T; Mizutani, Y; Kakushima, N; Ishikawa, T; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Furune, S; Hase, T; Yokota, K; Maeda, O; Hashimoto, N; Akiyama, M; Ando, Y; Fujishiro, M

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 27 ( 41 ) page: 7190 - 7206   2021.11

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  81. Gastrointestinal: Pancreatic metastasis from extramammary Paget's disease diagnosed by endoscopic ultrasound-guided fine-needle biopsy Reviewed

    Suzuki, H; Ishikawa, T; Ohno, E; Kawashima, H; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 36 ( 11 ) page: 3000 - 3000   2021.11

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  82. Endocytoscopy Is Useful for the Diagnosis of Superficial Nonampullary Duodenal Epithelial Tumors Reviewed

    Hirose, T; Kakushima, N; Furukawa, K; Furune, S; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Nishida, K; Yokoi, T; Kawashima, H; Fujishiro, M

    DIGESTION   Vol. 102 ( 6 ) page: 895 - 902   2021.11

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  83. Imaging diagnosis of autoimmune pancreatitis using endoscopic ultrasonography Reviewed

    Ishikawa, T; Kawashima, H; Ohno, E; Mizutani, Y; Fujishiro, M

    JOURNAL OF MEDICAL ULTRASONICS   Vol. 48 ( 4 ) page: 543 - 553   2021.10

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  84. Differentiation between pancreatic metastases from renal cell carcinoma and pancreatic neuroendocrine neoplasm using endoscopic ultrasound Reviewed

    Kataoka, K; Ishikawa, T; Ohno, E; Mizutani, Y; Iida, T; Ishikawa, E; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Kawashima, H; Hirooka, Y; Fujishiro, M

    PANCREATOLOGY   Vol. 21 ( 7 ) page: 1364 - 1370   2021.10

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  85. An Unusual Pancreatic Mass with Ductal Disruption: Benign or Malignant? Type 2 Autoimmune Pancreatitis Reviewed

    Takada, Y; Ishikawa, T; Kawashima, H

    GASTROENTEROLOGY   Vol. 161 ( 4 ) page: 1113 - 1115   2021.10

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  86. Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms Reviewed

    Esaki, M; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Suzuki, H; Kuno, T; Yamada, K; Hasegawa, I; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Kawashima, H; Hirooka, Y; Fujishiro, M

    DIGESTION   Vol. 102 ( 5 ) page: 701 - 713   2021.9

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  87. A forward-viewing radial-array echoendoscope is useful for diagnosing the depth of colorectal neoplasia invasion Reviewed

    Kuno, T; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Mizutani, Y; Esaki, M; Ishikawa, T; Furukawa, K; Ohno, E; Kawashima, H; Fujishiro, M

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 35 ( 8 ) page: 4389 - 4398   2021.8

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  88. Feasibility of patency capsule and colon capsule endoscopy in patients with suspected gastrointestinal stenosis: a prospective study Reviewed

    Otsuka, H; Nakamura, M; Yamamura, T; Maeda, K; Sawade, T; Mizutani, Y; Ishikawa, E; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Kawashima, I; Honda, T; Ishigami, M; Fujishiro, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 3 ) page: 419 - 430   2021.8

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  89. Double common bile duct associated with pancreaticobiliary maljunction Reviewed

    Yamada, K; Ishikawa, T; Ohno, E; Iida, T; Suzuki, H; Uetsuki, K; Yashika, J; Yoshikawa, M; Takami, H; Inokawa, Y; Uchida, H; Kawashima, H; Fujishiro, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 3 ) page: 655 - 661   2021.8

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  90. Detection of Colorectal Neoplasms Using Linked Color Imaging: A Prospective, Randomized, Tandem Colonoscon Trial Reviewed

    Hasegawa, I; Yamamura, T; Suzuki, H; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Kawashima, H; Nakamura, M; Fujishiro, M

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   Vol. 19 ( 8 ) page: 1708 - +   2021.8

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  91. Lewis score on capsule endoscopy can predict the prognosis in patients with small bowel lesions of Crohn's disease Reviewed

    Nishikawa, T; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 36 ( 7 ) page: 1851 - 1858   2021.7

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  92. Subjective Symptoms in Patients with Eosinophilic Esophagitis Are Related to Esophageal Wall Thickness and Esophageal Body Pressure Reviewed

    Muroi, K; Kakushima, N; Furukawa, K; Ishikawa, E; Sawada, T; Ishikawa, T; Maeda, K; Yamamura, T; Ohno, E; Nakamura, M; Kawashima, H; Funasaka, K; Miyahara, R; Fujishiro, M

    DIGESTIVE DISEASES AND SCIENCES   Vol. 66 ( 7 ) page: 2291 - 2300   2021.7

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  93. Endoscopic papillectomy for ampullary adenoma and early adenocarcinoma: Analysis of factors related to treatment outcome and long-term prognosis Reviewed

    Kawashima, H; Ohno, E; Ishikawa, T; Iida, T; Tanaka, H; Furukawa, K; Nakamura, M; Honda, T; Hashimoto, S; Itoh, A; Ishigami, M; Hirooka, Y; Fujishiro, M

    DIGESTIVE ENDOSCOPY   Vol. 33 ( 5 ) page: 858 - 869   2021.7

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  94. Long-Term Prognostic Predictors of Esophageal Squamous Cell Carcinoma Potentially Indicated for Endoscopic Submucosal Dissection Reviewed

    Suzuki, T; Furukawa, K; Funasaka, K; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Miyahara, R; Fujishiro, M

    DIGESTION   Vol. 102 ( 4 ) page: 563 - 571   2021.6

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  95. Endosonography-guided transmural drainage of pancreatic fluid collections: comparative outcomes by stent type Reviewed

    Kayal, A; Taghizadeh, N; Ishikawa, T; Gonzalez-Moreno, E; Bass, S; Cole, MJ; Heitman, SJ; Mohamed, R; Turbide, C; Chen, YI; Forbes, N

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 35 ( 6 ) page: 2698 - 2708   2021.6

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  96. An initial trial of quantitative evaluation of autoimmune pancreatitis using shear wave elastography and shear wave dispersion in transabdominal ultrasound Reviewed

    Suzuki, H; Ishikawa, T; Ohno, E; Iida, T; Uetsuki, K; Yashika, J; Yamada, K; Yoshikawa, M; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Kawashima, H; Fujishiro, M

    PANCREATOLOGY   Vol. 21 ( 4 ) page: 682 - 687   2021.6

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  97. An evaluation of resectability among endoscopic treatment methods for rectal neuroendocrine tumors &lt;10 mm Reviewed

    Toriyama, K; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Furukawa, K; Ishikawa, T; Ohno, E; Kawashima, H; Fujishiro, M

    ARAB JOURNAL OF GASTROENTEROLOGY   Vol. 22 ( 2 ) page: 104 - 110   2021.6

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  98. Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus Reviewed

    Muroi, K; Miyahara, R; Funasaka, K; Furukawa, K; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Onoue, T; Arima, H; Hirooka, Y; Fujishiro, M

    DIGESTION   Vol. 102 ( 4 ) page: 554 - 562   2021.6

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  99. Immunohistochemical staining for IMP3 in patients with duodenal papilla tumors: assessment of the potential for diagnosing endoscopic resectability and predicting prognosis Invited Reviewed

    Tanaka, H; Kawashima, H; Ohno, E; Ishikawa, T; Iida, T; Ishikawa, E; Furukawa, K; Nakamura, M; Honda, T; Shimoyama, Y; Miyahara, R; Kawabe, N; Kuzuya, T; Hashimoto, S; Ishigami, M; Hirooka, Y; Fujishiro, M

    BMC GASTROENTEROLOGY   Vol. 21 ( 1 ) page: 224   2021.5

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  100. Measurement of fasting breath hydrogen concentration as a simple diagnostic method for pancreatic exocrine insufficiency Reviewed

    Uetsuki, K; Kawashima, H; Ohno, E; Ishikawa, T; Iida, T; Yamamoto, K; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Hirooka, Y; Fujishiro, M

    BMC GASTROENTEROLOGY   Vol. 21 ( 1 ) page: 211   2021.5

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  101. Diagnostic performance of endoscopic ultrasonography-guided elastography for solid pancreatic lesions: Shear-wave measurements versus strain elastography with histogram analysis Reviewed

    Ohno, E; Kawashima, H; Ishikawa, T; Iida, T; Suzuki, H; Uetsuki, K; Yashika, J; Yamada, K; Yoshikawa, M; Gibo, N; Aoki, T; Kataoka, K; Mori, H; Yamamura, T; Furukawa, K; Nakamura, M; Hirooka, Y; Fujishiro, M

    DIGESTIVE ENDOSCOPY   Vol. 33 ( 4 ) page: 629 - 638   2021.5

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  102. Endoscopic removal of a fish bone piercing the bile duct after pancreaticoduodenectomy Reviewed

    Ishikawa, T; Kawashima, H; Ohno, E; Nakamura, M; Yamada, S; Hayashi, M; Fujishiro, M

    ENDOSCOPY   Vol. 53 ( 05 ) page: E164 - E165   2021.5

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  103. Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy Reviewed

    Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Kakushima, N; Furukawa, K; Ishikawa, T; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Fujishiro, M

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 2021   page: 8875564   2021.4

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  104. Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer Reviewed

    Yoshikawa, M; Ishikawa, T; Ohno, E; Iida, T; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Kinoshita, F; Kawashima, H; Fujishiro, M

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 7409   2021.4

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  105. Filtrated Adipose Tissue-Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice Reviewed

    Nishikawa, T; Maeda, K; Nakamura, M; Yamamura, T; Sawada, T; Mizutani, Y; Ito, T; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Honda, T; Ishigami, M; Yamamoto, T; Matsumoto, S; Hotta, Y; Fujishiro, M

    DIGESTIVE DISEASES AND SCIENCES   Vol. 66 ( 4 ) page: 1034 - 1044   2021.4

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  106. Utility of multiphase contrast enhancement patterns on CEH-EUS for the differential diagnosis of IPMN-derived and conventional pancreatic cancer

    Yashika, J; Ohno, E; Ishikawa, T; Iida, T; Suzuki, H; Uetsuki, K; Yamada, K; Yoshikawa, M; Gibo, N; Shimoyama, Y; Ishikawa, E; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Hirooka, Y; Kawashima, H; Fujishiro, M

    PANCREATOLOGY   Vol. 21 ( 2 ) page: 390 - 396   2021.3

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  107. Endoscopic ultrasound elastography for small solid pancreatic lesions with or without main pancreatic duct dilatation

    Kataoka, K; Ishikawa, T; Ohno, E; Iida, T; Suzuki, H; Uetsuki, K; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Kawashima, H; Hirooka, Y; Fujishiro, M

    PANCREATOLOGY   Vol. 21 ( 2 ) page: 451 - 458   2021.3

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  108. Diagnostic yield of colon capsule endoscopy for Crohn's disease lesions in the whole gastrointestinal tract

    Yamada, K; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Kawashima, H; Honda, T; Ishigami, M; Fujishiro, M

    BMC GASTROENTEROLOGY   Vol. 21 ( 1 ) page: 75   2021.2

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  109. Clinical characteristics and long-term prognosis of autoimmune pancreatitis with renal lesions

    Ishikawa, T; Kawashima, H; Ohno, E; Iida, T; Suzuki, H; Uetsuki, K; Yashika, J; Yamada, K; Yoshikawa, M; Gibo, N; Aoki, T; Kataoka, K; Mori, H; Yamamura, T; Furukawa, K; Nakamura, M; Hirooka, Y; Fujishiro, M

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 406   2021.1

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  110. The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease

    Hattori, S; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Yamamoto, K; Ishikawa, T; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Hirooka, Y; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY   Vol. 55 ( 12 ) page: 1138 - 1149   2020.12

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  111. Risks and characteristics of pancreatic cancer and pancreatic relapse in autoimmune pancreatitis patients

    Ishikawa, T; Kawashima, H; Ohno, E; Iida, T; Suzuki, H; Uetsuki, K; Yamada, K; Yashika, J; Yoshikawa, M; Gibo, N; Aoki, T; Kataoka, K; Mori, H; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 35 ( 12 ) page: 2281 - 2288   2020.12

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  112. Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy

    Niwa, Y; Nakamura, M; Kawashima, H; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Ishigami, M; Fujishiro, M

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 26 ( 42 ) page: 6669 - 6678   2020.11

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  113. Mutation analysis of gastrointestinal stromal tumors using RNA obtained via endoscopic ultrasound-guided fine-needle aspiration

    Funasaka, K; Miyahara, R; Furukawa, K; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Hirooka, Y; Ohmiya, N; Fujishiro, M

    TRANSLATIONAL ONCOLOGY   Vol. 13 ( 11 ) page: 100848   2020.11

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  114. Endoscopic Activity and Serum TNF-α Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn's Disease Patients

    Murate, K; Maeda, K; Nakamura, M; Sugiyama, D; Wada, H; Yamamura, T; Sawada, T; Mizutani, Y; Ishikawa, T; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Miyahara, R; Ishigami, M; Nishikawa, H; Fujishiro, M

    INFLAMMATORY BOWEL DISEASES   Vol. 26 ( 11 ) page: 1669 - 1681   2020.11

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  115. Usefulness of endoscopic ultrasound-guided fine-needle biopsy for the diagnosis of autoimmune pancreatitis using a 22-gauge Franseen needle: a prospective multicenter study

    Ishikawa, T; Kawashima, H; Ohno, E; Suhara, H; Hayashi, D; Hiramatsu, T; Matsubara, H; Suzuki, T; Kuwahara, T; Ishikawa, E; Shimoyama, Y; Kinoshita, F; Hirooka, Y; Fujishiro, M

    ENDOSCOPY   Vol. 52 ( 11 ) page: 978 - 985   2020.11

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  116. AMINO ACID POLYMORPHISM IN HEPATITIS B VIRUS ASSOCIATED WITH NATURAL CLEARANCE OF HBV DNA AND HBsAg

    Honda Takashi, Yamada None, Murayama Asako, Kato Asuka, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Ishigami Masatoshi, Murakami Yoshiki, Ishikawa Tetsuya, Fujishiro Mitsuhiro, Kato Takanobu

    HEPATOLOGY   Vol. 72   page: 508A - 509A   2020.11

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  117. What is the role of measuring shear wave dispersion using shear wave elastography in pancreatic parenchyma?

    Suzuki, H; Kawashima, H; Ohno, E; Ishikawa, T; Hashimoto, S; Nakamura, M; Miyahara, R; Ishigami, M; Hirooka, Y; Fujishiro, M

    JOURNAL OF MEDICAL ULTRASONICS   Vol. 47 ( 4 ) page: 575 - 581   2020.10

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  118. Can contrast-enhanced harmonic endoscopic ultrasonography accurately diagnose main pancreatic duct involvement in intraductal papillary mucinous neoplasms?

    Ohno, E; Kawashima, H; Ishikawa, T; Iida, T; Suzuki, H; Uetsuki, K; Yashika, J; Yamada, K; Yoshikawa, M; Gibo, N; Aoki, T; Kataoka, K; Mori, H; Hirooka, Y; Fujishiro, M

    PANCREATOLOGY   Vol. 20 ( 5 ) page: 887 - 894   2020.7

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  119. Gender difference in the transabdominal ultrasound findings of solid-pseudopapillary neoplasm

    Sasaki, Y; Ishikawa, T; Kawashima, H; Ohno, E; Shimoyama, Y; Ishikawa, E; Fujishiro, M

    PANCREATOLOGY   Vol. 20 ( 5 ) page: 997 - 1003   2020.7

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  120. Giant fibrovascular polyp of the esophagus with intermittent airway obstruction

    Ishikawa, T; Bishay, K; Belletrutti, PJ; Gui, XY; Forbes, N

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY   Vol. 32 ( 7 ) page: 895 - 896   2020.7

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  121. Endoscopic ultrasonography for the evaluation of pancreatic cystic neoplasms

    Ohno, E; Hirooka, Y; Kawashima, H; Ishikawa, T; Fujishiro, M

    JOURNAL OF MEDICAL ULTRASONICS   Vol. 47 ( 3 ) page: 401 - 411   2020.7

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  122. Use of Immunostaining for the diagnosis of Lymphovascular invasion in superficial Barrett's esophageal adenocarcinoma

    Hosono, I; Miyahara, R; Furukawa, K; Funasaka, K; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Yokoi, T; Hirooka, Y; Fujishiro, M; Tsukamoto, T

    BMC GASTROENTEROLOGY   Vol. 20 ( 1 ) page: 175   2020.6

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  123. ENDOSCOPIC DIAGNOSIS USING MAGNIFYING IMAGE-ENHANCED ENDOSCOPY FOR SUPERFICIAL NON-AMPULLARY DUODENAL EPITHELIAL TUMORS

    Furukawa, K; Miyahara, R; Funasaka, K; Sawada, T; Keiko, M; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Fujishiro, M

    GASTROINTESTINAL ENDOSCOPY   Vol. 91 ( 6 ) page: AB618 - AB618   2020.6

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  124. PROSPECTIVE MULTICENTER STUDY ON THE USEFULNESS OF EUS-GUIDED FINE NEEDLE BIOPSY FOR THE DIAGNOSIS OF AUTOIMMUNE PANCREATITIS USING A 22-GAUGE FRANSEEN NEEDLE

    Ishikawa, T; Kawashima, H; Ohno, E; Nishio, R; Iida, T; Suzuki, H; Uetsuki, K; Yamada, K; Yashika, J; Yoshikawa, M; Gibo, N; Aoki, T; Kataoka, K; Mori, H; Keiko, M; Sawada, T; Yamamura, T; Furukawa, K; Nakamura, M; Fujishiro, M

    GASTROINTESTINAL ENDOSCOPY   Vol. 91 ( 6 ) page: AB172 - AB172   2020.6

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  125. NOVEL METHOD TO DETERMINE THE DEPTH OF INVASION IN COLORECTAL NEOPLASMS WITH ULTRASOUND ELASTOGRAPHY USING A FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE

    Esaki, M; Yamamura, T; Nakamura, M; Keiko, M; Sawada, T; Mizutani, Y; Kuno, T; Yamada, K; Hasegawa, I; Ishikawa, T; Furukawa, K; Ohno, E; Kawashima, H; Fujishiro, M

    GASTROINTESTINAL ENDOSCOPY   Vol. 91 ( 6 ) page: AB430 - AB430   2020.6

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  126. EVALUATION OF RESECTABILITY BETWEEN ENDOSCOPIC TREATMENT METHODS FOR RECTAL NEUROENDOCRINE TUMOR

    Toriyama, K; Yamamura, T; Nakamura, M; Keiko, M; Sawada, T; Mizutani, Y; Ishikawa, T; Furukawa, K; Ohno, E; Kawashima, H; Fujishiro, M

    GASTROINTESTINAL ENDOSCOPY   Vol. 91 ( 6 ) page: AB101 - AB101   2020.6

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  127. Clinical Factors Associated with Missing Colorectal Polyp on Colon Capsule Endoscopy

    Yamada, K; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Hotta, N; Hirooka, Y

    DIGESTION   Vol. 101 ( 3 ) page: 316 - 322   2020.5

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  128. Diagnosis of vascular invasion in pancreatic ductal adenocarcinoma using endoscopic ultrasound elastography

    Yamada, K; Kawashima, H; Ohno, E; Ishikawa, T; Tanaka, H; Nakamura, M; Miyahara, R; Ishigami, M; Hirooka, Y; Fujishiro, M

    BMC GASTROENTEROLOGY   Vol. 20 ( 1 ) page: 81   2020.3

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  129. Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study

    Nishio, R; Kawashima, H; Nakamura, M; Ohno, E; Ishikawa, T; Yamamura, T; Maeda, K; Sawada, T; Tanaka, H; Sakai, D; Miyahara, R; Ishigami, M; Hirooka, Y; Fujishiro, M

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 26 ( 10 ) page: 1056 - 1066   2020.3

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  130. Usefulness of Endoscopic Ultrasound Elastography Combined With the Strain Ratio in the Estimation of Treatment Effect in Autoimmune Pancreatitis

    Ishikawa, T; Kawashima, H; Ohno, E; Tanaka, H; Maeda, K; Sawada, T; Yamamura, T; Furukawa, K; Nakamura, M; Miyahara, R; Ishigami, M; Fujishiro, M

    PANCREAS   Vol. 49 ( 2 ) page: E21 - E22   2020.2

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  131. Color information from linked color imaging is associated with invasion depth and vascular diameter in superficial esophageal squamous cell carcinoma

    Kobayashi, K; Miyahara, R; Funasaka, K; Furukawa, K; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Nakaguro, M; Okumura, Y; Hirooka, Y; Fujishiro, M

    DIGESTIVE ENDOSCOPY   Vol. 32 ( 1 ) page: 65 - 73   2020.1

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  132. Generation of magnifying endoscopic images of gastric neoplasms based on an all-in-focus algorithm

    Matsui, K; Funasaka, K; Miyahara, R; Furukawa, K; Matsushita, M; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Watanabe, O; Ohara, K; Hirooka, Y; Goto, H

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 35 ( 1 ) page: 65 - 70   2020.1

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  133. A Prospective Study of Factors Associated with Abdominal Pain in Patients during Unsedated Colonoscopy Using a Magnifying Endoscope

    Suzuki, H; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, T; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Fujishiro, M

    INTERNAL MEDICINE   Vol. 59 ( 15 ) page: 1795 - 1801   2020

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  134. Nasal patency as a factor for successful transnasal endoscopy

    Nagaya, T; Miyahara, R; Funasaka, K; Furukawa, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Nakashima, T; Nakata, S; Hirooka, Y

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 4 ) page: 587 - 595   2019.11

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  135. Feasibility and usefulness of endoscopic ultrasonography-guided shear-wave measurement for assessment of autoimmune pancreatitis activity: a prospective exploratory study

    Ohno, E; Hirooka, Y; Kawashima, H; Ishikawa, T; Tanaka, H; Sakai, D; Ishizu, Y; Kuzuya, T; Nakamura, M; Honda, T

    JOURNAL OF MEDICAL ULTRASONICS   Vol. 46 ( 4 ) page: 425 - 433   2019.10

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  136. Mucinous cystic neoplasm of the pancreas assessed with a real-time three-dimensional imaging using a transesophageal echocardiography probe.

    Ishikawa T, Hirooka Y, Kawashima H, Ohno E, Fujishiro M

    Clinical journal of gastroenterology   Vol. 12 ( 5 ) page: 479 - 483   2019.10

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  137. Increased hardness of the underlying pancreas correlates with the presence of intraductal papillary-mucinous neoplasm in a limited number of cases

    Koya, T; Kawashima, H; Ohno, E; Ishikawa, T; Ishigami, M; Hashimoto, S; Goto, H; Hirooka, Y

    JOURNAL OF MEDICAL ULTRASONICS   Vol. 46 ( 4 ) page: 441 - 447   2019.10

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  138. Objective evaluation of the therapeutic effect of ustekinumab on Crohn's disease

    Yamamura, T; Nakamura, M; Murate, K; Maeda, K; Sawada, T; Mizutani, Y; Nishikawa, T; Hattori, S; Yamamoto, K; Pu, LZCT; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 34   page: 145 - 145   2019.9

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  139. Specific members of gut microbiota predict mucosal healing in Crohn's disease

    Hattori, S; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Yamamoto, K; Pu, LZCT; Honda, T; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 34   page: 152 - 152   2019.9

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  140. THE PROPAGATION DISPLAY METHOD IMPROVES THE REPRODUCIBILITY OF PANCREATIC SHEAR WAVE ELASTOGRAPHY

    Hashizume, K; Hirooka, Y; Kawashima, H; Ohno, E; Ishikawa, T; Kawai, M; Suhara, H; Takeyama, T; Koya, T; Tanaka, H; Sakai, D; Yamamura, T; Furukawa, K; Funasaka, K; Nakamura, M; Miyahara, R; Watanabe, O; Ishigami, M; Kuwahara, T; Hashimoto, S; Goto, H

    ULTRASOUND IN MEDICINE AND BIOLOGY   Vol. 45 ( 8 ) page: 2242 - 2247   2019.8

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  141. Comparison of 8-mm and 10-mm Diameter Fully-Covered Self-Expandable Metal Stents: A Multicenter Prospective Study in Patients with Distal Malignant Biliary Obstruction.

    Kawashima H, Hashimoto S, Ohno E, Ishikawa T, Morishima T, Matsubara H, Sugimoto H, Nonogaki K, Kanamori A, Hara K, Kuwahara T, Nakamura M, Miyahara R, Ishigami M, Ando M, Hirooka Y, Nagoya Biliary Stent Study (NABIS)-01 Group.

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   Vol. 31 ( 4 ) page: 439 - 447   2019.7

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    DOI: 10.1111/den.13366

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  142. CLINICAL SIGNIFICANCE OF THE PATENCY OF GASTROINTESTINAL TRACT IN CROHN'S DISEASE EVALUATED BY PATENCY CAPSULE

    Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Kuno, T; Yamada, K; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Hirooka, Y

    GASTROINTESTINAL ENDOSCOPY   Vol. 89 ( 6 ) page: AB333 - AB333   2019.6

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    DOI: 10.1016/j.gie.2019.03.453

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  143. USEFULLNESS OF EUS-GUIDED SHEAR-WAVE MEASUREMENT (EUS-SWM) FOR THE ASSESSMENT OF ACTIVITIES OF AUTOIMMUNE PANCREATITIS; A PROSPECTIVE EXPLORATORY STUDY

    Ohno, E; Hirooka, Y; Kawashima, H; Ishikawa, T; Tanaka, H; Sakai, D; Iida, T; Nishio, R; Suzuki, H; Uetsuki, K; Yashika, J; Yamada, K; Yoshikawa, M; Gibo, N; Aoki, T; Yamamura, T; Furukawa, K; Nakamura, M; Miyahara, R

    GASTROINTESTINAL ENDOSCOPY   Vol. 89 ( 6 ) page: AB608 - AB608   2019.6

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  144. USEFULNESS OF THE FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE IN THE DIAGNOSIS OF INVASION DEPTH OF COLORECTAL NEOPLASIA

    Kuno, T; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Mizutani, Y; Suzuki, H; Esaki, M; Ishikawa, T; Furukawa, K; Ohno, E; Kawashima, H; Miyahara, R; Hirooka, Y

    GASTROINTESTINAL ENDOSCOPY   Vol. 89 ( 6 ) page: AB324 - AB324   2019.6

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    DOI: 10.1016/j.gie.2019.03.427

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  145. FACTORS RELATED TO MISSED COLORECTAL POLYPS ON COLON CAPSULE ENDOSCOPY IN CLINICAL PRACTICE

    Yamada, K; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Niwa, Y; Ishikawa, E; Otsuka, H; Suzuki, H; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Hotta, N; Pu, LZCT; Hirooka, Y

    GASTROINTESTINAL ENDOSCOPY   Vol. 89 ( 6 ) page: AB155 - AB155   2019.6

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    DOI: 10.1016/j.gie.2019.03.067

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  146. Feasibility of EUS-guided shear-wave measurement: A preliminary clinical study

    Ohno, E; Hirooka, Y; Kawashima, H; Ishikawa, T

    ENDOSCOPIC ULTRASOUND   Vol. 8 ( 3 ) page: 215 - 216   2019.5

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  147. Phase II study of chemoradiotherapy combined with gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic ductal adenocarcinoma (NUPAT 05 Trial): study protocol for a single arm phase II study

    Takano, N; Yamada, S; Hirakawa, A; Yokoyama, Y; Kawashima, H; Maeda, O; Okada, T; Ohno, E; Yamaguchi, J; Ishikawa, T; Sonohara, F; Suenaga, M; Takami, H; Hayashi, M; Niwa, Y; Hirooka, Y; Ito, Y; Naganawa, S; Ando, Y; Nagino, M; Goto, H; Fuji, T; Kodera, Y

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page: 233 - 239   2019.5

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  148. Utility of linked color imaging for endoscopic diagnosis of early gastric cancer

    Fujiyoshi, T; Miyahara, R; Funasaka, K; Furukawa, K; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Nakaguro, M; Nakatochi, M; Hirooka, Y

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 25 ( 10 ) page: 1248 - 1258   2019.3

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  149. Transabdominal ultrasound elastography of the esophagogastric junction predicts reflux esophagitis

    Suhara Hiroki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi

    JOURNAL OF MEDICAL ULTRASONICS   Vol. 46 ( 1 ) page: 99 - 104   2019.1

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    DOI: 10.1007/s10396-018-0890-1

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  150. A Case of Plummer-Vinson Syndrome with Esophageal Web Formation in which Detailed Endoscopic Images Were Obtained.

    Hirose T, Funasaka K, Furukawa K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Miyahara R, Hirooka Y

    Internal medicine (Tokyo, Japan)   Vol. 58 ( 6 ) page: 785 - 789   2019

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    DOI: 10.2169/internalmedicine.1628-18

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  151. Randomized Phase II Study of Consecutive-Day versus Alternate-Day Treatment with S-1 as Second-Line Chemotherapy in Advanced Pancreatic Cancer

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Matsubara Hiroshi, Sasaki Yoji, Achiwa Koichi, Kanamori Akira, Sumi Hajime, Hirai Takanori, Nonogaki Koji, Tsuzuki Tomoyuki, Kuroiwa Masanori, Hattori Masashi, Maruta Shinya, Hiramatsu Takeshi, Ando Masahiko, Hashimoto Senju, Hirooka Yoshiki

    ONCOLOGY   Vol. 96 ( 1 ) page: 1 - 7   2019

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    DOI: 10.1159/000492388

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  152. Clinical Impact of EUS-Guided Fine Needle Biopsy Using a Novel Franseen Needle for Histological Assessment of Pancreatic Diseases

    Ishikawa, T; Kawashima, H; Ohno, E; Tanaka, H; Sakai, D; Iida, T; Nishio, R; Yamamura, T; Furukawa, K; Nakamura, M; Miyahara, R; Hashimoto, S; Ishigami, M; Hirooka, Y

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 2019   page: 8581743   2019

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  153. Lewis Score on Capsule Endoscopy as a Predictor of the Risk for Crohn's Disease-Related Emergency Hospitalization and Clinical Relapse in Patients with Small Bowel Crohn's Disease

    Nishikawa, T; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Hirooka, Y

    GASTROENTEROLOGY RESEARCH AND PRACTICE   Vol. 2019   page: 4274257   2019

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  154. Validity of Capsule Endoscopy in Monitoring Therapeutic Interventions in Patients with Crohn's Disease

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Koulaouzidis Anastasios, Hirooka Yoshiki

    JOURNAL OF CLINICAL MEDICINE   Vol. 7 ( 10 )   2018.10

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    DOI: 10.3390/jcm7100311

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  155. Effectiveness of a modified 6-Fr endoscopic nasobiliary drainage catheter for patients with preoperative perihilar cholangiocarcinoma

    Kawashima Hiroki, Hirooka Yoshiki, Ohno Eizaburo, Ishikawa Takuya, Miyahara Ryoji, Watanabe Osamu, Hayashi Kazuhiko, Ishigami Masatoshi, Hashimoto Senju, Ebata Tomoki, Nagino Masato, Goto Hidemi

    ENDOSCOPY INTERNATIONAL OPEN   Vol. 6 ( 8 ) page: E1020 - E1030   2018.8

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    DOI: 10.1055/a-0614-2202

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  156. Objective evaluation of blood flow in the small-intestinal villous: quantification of findings from dynamic endoscopy with concomitant narrow-band imaging

    Takeyama Tomoaki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Goto Hidemi

    ENDOSCOPY INTERNATIONAL OPEN   Vol. 6 ( 8 ) page: E941 - E949   2018.8

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    DOI: 10.1055/a-0619-4965

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  157. Neuroendocrine neoplasm of pancreas with cystic degeneration mimicking mucinous cystic neoplasm

    Kaosombatwattana Uayporn, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Suhara Hiroki, Goto Hidemi

    CLINICAL JOURNAL OF GASTROENTEROLOGY   Vol. 11 ( 4 ) page: 333 - 337   2018.8

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    DOI: 10.1007/s12328-018-0846-4

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  158. Increase in breath hydrogen concentration was correlated with the main pancreatic duct stenosis.

    Sakai D, Hirooka Y, Kawashima H, Ohno E, Ishikawa T, Suhara H, Takeyama T, Koya T, Tanaka H, Iida T, Nishio R, Suzuki H, Uetsuki K, Matsushita M, Yamamura T, Furukawa K, Funasaka K, Nakamura M, Miyahara R, Watanabe O, Ishigami M, Tsuruta A, Shin W, Goto H

    Journal of breath research   Vol. 12 ( 3 ) page: 036004   2018.7

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    DOI: 10.1088/1752-7163/aaaf77

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  159. Measurements of renal shear wave velocities in chronic kidney disease patients.

    Sasaki Y, Hirooka Y, Kawashima H, Ishikawa T, Takeshita K, Goto H

    Acta radiologica (Stockholm, Sweden : 1987)   Vol. 59 ( 7 ) page: 884 - 890   2018.7

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    DOI: 10.1177/0284185117734417

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  160. International consensus statements on early chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with The International Association of Pancreatology, American Pancreatic Association, Japan Pancreas Society, PancreasFest Working Group and European Pancreatic Club

    Whitcomb David C., Shimosegawa Tooru, Chari Suresh T., Forsmark Christopher E., Frulloni Luca, Garg Pramod, Hegyi Peter, Hirooka Yoshiki, Irisawa Atsushi, Ishikawa Takuya, Isaji Shuiji, Lerch Markus M., Levy Philippe, Masamune Atsushi, Wilcox Charles M., Windsor John, Yadav Dhiraj, Sheel Andrea, Neoptolemos John P.

    PANCREATOLOGY   Vol. 18 ( 5 ) page: 516 - 527   2018.7

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    DOI: 10.1016/j.pan.2018.05.008

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  161. DIAGNOSTIC IMAGING SYSTEM WITH VIRTUAL ENTEROSCOPY AND COMPUTER-AIDED DETECTION FOR EVALUATION OF SMALL BOWEL LESIONS OF CROHN'S DISEASE

    Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Suhara Hiroki, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Oda Masahiro, Mori Kensaku, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB304 - AB304   2018.6

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  162. USEFULNESS OF HISTOLOGICAL ASSESSMENT WITH EUS-GUIDED FINE NEEDLE BIOPSY USING A NEW CORE NEEDLE IN PANCREATIC DISEASES

    Ishikawa Takuya, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB432 - AB433   2018.6

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  163. USEFULLNESS OF CONTRAST-ENHANCED HARMONIC EUS(CH-EUS) FOR THE PREOPERATIVE ASSESSMENT OF MPD INVOLVEMENT IN IPMN; A RETROSPECTIVE COMPARISON STUDY OF CH-EUS AND IDUS

    Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Furukawa Kazuhiro, Yamamura Takeshi, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB426 - AB427   2018.6

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  164. THE DIAGNOSTIC ABILITY AND PITFALL OF JNET(JAPAN NBI EXPERT TEAM)CLASSIFICATION IN TRAINEES

    Suzuki Hiroto, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Niwa Yoshiki, Uchida Genta, Otsuka Hiroyuki, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keisaku, Hattori Shun, Kajikawa Go, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB489 - AB490   2018.6

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  165. OUTCOMES AND PREDICTORS OF SEVERE SUBMUCOSAL FIBROSIS IN COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION

    Kaosombatwattana Uayporn, Yamamura Takeshi, Limsrivilai Julajak, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Leelakusolvong Somchai, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB377 - AB377   2018.6

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  166. EVALUATION OF LOCAL RECURRENCE AFTER COLD POLYPECTOMY COMPARED WITH CONVENTIONAL HOT POLYPECTOMY IN A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL

    Yamamura Takeshi, Saito Masashi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Suzuki Hiroto, Otsuka Hiroyuki, Uchida Genta, Nishikawa Takahiro, Ishida Tetsuya, Kuno Takeshi, Yamada Keisaku, Hattori Shun, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB478 - AB478   2018.6

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  167. ENDOSCOPIC TREATMENT FOR SUPERFICIAL NON-AMPULLARY DUODENAL TUMORS

    Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Suhara Hiroki, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB315 - AB316   2018.6

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  168. PROSPECTIVE STUDY OF SMALL BOWEL CAPSULE ENDOSCOPY FOR EVALUATING THE THERAPEUTIC EFFECTS IN PATIENTS WITH CROHN'S DISEASE

    Nakamura, M; Hirooka, Y; Watanabe, O; Yamamura, T; Matsushita, M; Suhara, H; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Koulaouzidis, A; Goto, H

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB393 - AB393   2018.6

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  169. A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer

    Hirooka Yoshiki, Kasuya Hideki, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Villalobos Itzel B., Naoe Yoshinori, Ichinose Toru, Koyama Nobuto, Tanaka Maki, Kodera Yasuhiro, Goto Hidemi

    BMC CANCER   Vol. 18 ( 1 ) page: 596   2018.5

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    DOI: 10.1186/s12885-018-4453-z

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  170. Fecal calprotectin reflects endoscopic activity in patients with small-bowel Crohn's disease according to double-balloon endoscopy findings

    Matsuura Rinzaburo, Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Suhara Hiroki, Furukawa Kazuhiro, Ishikawa Takuya, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 2 ) page: 257 - 266   2018.5

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    DOI: 10.18999/nagjms.80.2.257

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  171. Functional Correlation Between the Pancreas and the Small Intestine in Humans: The First Evaluation Using a Newly Developed Enteroscopy

    Hayashi Daijuro, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kuwahara Takamichi, Kawai Manabu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi

    PANCREAS   Vol. 47 ( 5 ) page: 601 - 608   2018.5

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    DOI: 10.1097/MPA.0000000000001039

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  172. Nomogram-based prediction of rebleeding in small bowel bleeding patients: the 'PRSBB' score

    Uchida Genta, Hirooka Yoshiki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 6378   2018.4

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    DOI: 10.1038/s41598-018-24868-0

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  173. Multiphase evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic solid lesions.

    Ishikawa T, Hirooka Y, Kawashima H, Ohno E, Hashizume K, Funasaka K, Nakamura M, Miyahara R, Watanabe O, Ishigami M, Goto H

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   Vol. 18 ( 3 ) page: 291 - 297   2018.4

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    DOI: 10.1016/j.pan.2018.02.002

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  174. Usefulness of shear wave elastography as a quantitative diagnosis of chronic pancreatitis

    Kuwahara Takamichi, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 33 ( 3 ) page: 756 - 761   2018.3

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    DOI: 10.1111/jgh.13926

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  175. Clinical significance of gastrointestinal patency evaluation by using patency capsule in Crohn's disease

    Yoshimura, T; Hirooka, Y; Nakamura, M; Watanabe, O; Yamamura, T; Matsushita, M; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Goto, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 1 ) page: 121 - 128   2018.2

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  176. Comprehensive immunotherapy combined with intratumoral injection of zoledronate-pulsed dendritic cells, intravenous adoptive activated T lymphocyte and gemcitabine in unresectable locally advanced pancreatic carcinoma: a phase I/II trial

    Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kamigaki Takashi, Goto Shigenori, Takahara Masashi, Goto Hidemi

    ONCOTARGET   Vol. 9 ( 2 ) page: 2838 - 2847   2018.1

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    DOI: 10.18632/oncotarget.22974

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  177. Natural history of pancreatic cystic lesions: A multicenter prospective observational study for evaluating the risk of pancreatic cancer

    Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Kanamori Akira, Ishikawa Hideki, Sasaki Yoji, Nonogaki Koji, Hara Kazuo, Hashimoto Senju, Matsubara Hiroshi, Hirai Takanori, Sumi Hajime, Sugimoto Hiroyuki, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 33 ( 1 ) page: 320 - 328   2018.1

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    DOI: 10.1111/jgh.13967

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  178. Diagnostic yield of small histological cores obtained with a new EUS-guided fine needle biopsy system

    Ishikawa Takuya, Mohamed Rachid, Heitman Steven J., Turbide Christian, Kumar Puja R., Goto Hidemi, Hirooka Yoshiki, Belletrutti Paul J.

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 31 ( 12 ) page: 5143 - 5149   2017.12

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    DOI: 10.1007/s00464-017-5580-3

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  179. Development and validation of a new scoring system to determine the necessity of small-bowel endoscopy in obscure gastrointestinal bleeding

    Uchida Genta, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    DIGESTIVE AND LIVER DISEASE   Vol. 49 ( 11 ) page: 1218 - 1224   2017.11

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    DOI: 10.1016/j.dld.2017.08.036

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  180. In vivo histological diagnosis for gastric cancer using endocytoscopy

    Tsurudome Issei, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Nakaguro Masato, Satou Akira, Hirooka Yoshiki, Goto Hidemi

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 23 ( 37 ) page: 6894 - 6901   2017.10

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    DOI: 10.3748/wjg.v23.i37.6894

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  181. ETV1 expression would be a predictive marker of malignancy in GIST

    Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 32   page: 79-80   2017.9

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  182. Making decision to treat with infliximab by the result of periodic surveillance with double-balloon endoscopy after ilectomy can obtain mucosal healing and avoid re-operation on patients with Crohn's disease for a long-term follow-up study

    Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Saito Masashi, Matsuura Rinzaburou, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keishi, Kuno Takeshi, Hattori Shun, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 32   page: 287 - 287   2017.9

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  183. Clinical factors related to false-positive rates of patency capsule examination

    Sawada Tsunaki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Elzaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   Vol. 10 ( 8 ) page: 589 - 598   2017.8

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    DOI: 10.1177/1756283X17722744

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  184. Prospective multicenter phase II study of gemcitabine plus cisplatin in patients with unresectable gallbladder cancer

    Hirooka Yoshiki, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Nonogaki Koji, Kanamori Akira, Hirai Takanori, Uchida Hiroki, Shirai Osamu, Ishikawa Hideki, Goto Hidemi

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   Vol. 80 ( 1 ) page: 119 - 125   2017.7

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    DOI: 10.1007/s00280-017-3341-6

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  185. Quantitative diagnosis of chronic pancreatitis using EUS elastography

    Kuwahara Takamichi, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kawai Manabu, Suhara Hiroki, Takeyama Tomoaki, Hashizume Kiyotaka, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY   Vol. 52 ( 7 ) page: 868 - 874   2017.7

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    DOI: 10.1007/s00535-016-1296-8

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  186. Clinical Factors Related to False Positive Rates of Patency Capsule Examination

    Sawada Tsunaki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB305 - AB305   2017.5

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    DOI: 10.1016/j.gie.2017.03.699

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  187. Novel EMR Technique for Preoperative Diagnosis and Treatment of Submucosal Tumor in the Small Bowel at Double-Balloon Endoscopy

    Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB300 - AB300   2017.5

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    DOI: 10.1016/j.gie.2017.03.685

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  188. Predicting the Depth of Invasion of Esophageal Squamous Cell Carcinoma: Under Experience of Linked Colored Imaging With LED Light Source

    Kobayashi Kenichi, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB527 - AB527   2017.5

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    DOI: 10.1016/j.gie.2017.03.1214

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  189. Establishment of a New Scoring System for Predicting the Necessity of Double-Balloon Endoscopy in Obscure Gastrointestinal Bleeding

    Uchida Genta, Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB300 - AB300   2017.5

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    DOI: 10.1016/j.gie.2017.03.687

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  190. The Study of Diagnostic Ability for the Colorectal Neoplasms by Imaged Enhanced Endoscopy Using by JNET (Japan NBI Expert Team) Classification

    Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Matsuura Rinzaburo, Saito Masashi, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB402 - AB402   2017.5

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    DOI: 10.1016/j.gie.2017.03.932

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  191. The Outcome of Treatment in Hypopharyngeal and Cervical Esophageal Carcinoma

    Fujiyoshi Toshihisa, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB597 - AB598   2017.5

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    DOI: 10.1016/j.gie.2017.03.1377

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  192. One Year Follow-Up After Cold Polypectomy Compared With Hot Polypectomy for Small Colorectal Polyps - a Prospective Randomized Controlled Trial

    Saito Masashi, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB365 - AB366   2017.5

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    DOI: 10.1016/j.gie.2017.03.845

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  193. Objective Assessment of Jejunal Villous Blood Flow for Evaluating Pancreas-Jejunum Functional Correlation Using a Novel Image Analyzing System

    Takeyama Tomoaki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kawai Manabu, Suhara Hiroki, Hashizume Kiyotaka, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB319 - AB320   2017.5

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    DOI: 10.1016/j.gie.2017.03.736

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  194. An Unusual Case of Pancreatic Metastasis from Squamous Cell Carcinoma of the Lung Diagnosed by EUS-Guided Fine Needle Biopsy

    Ishikawa Takuya, Hirooka Yoshiki, Teman Carolin J., Goto Hidemi, Belletrutti Paul J.

    CASE REPORTS IN GASTROINTESTINAL MEDICINE   Vol. 2017   page: 3212056   2017

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    DOI: 10.1155/2017/3212056

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  195. Risk factors for rebleeding and risk-based follow-up of obscure gastrointestinal bleeding after its initial diagnosis.

    Uchida G, Nakamura M, Watanabe O, Yamamura T, Matsushita M, Ishikawa T, Furukawa K, Funasaka K, Ohno E, Kawashima H, Miyahara R, Goto H, Hirooka Y

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   Vol. 114 ( 10 ) page: 1819 - 1829   2017

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    DOI: 10.11405/nisshoshi.114.1819

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Research Project for Joint Research, Competitive Funding, etc. 4

  1. 膵充実性病変に対するEUS-FNB 1セッションあたりの適切な前後運動回数に関する研究

    2021.4 - 2022.3

    堀財団  堀財団先端研究支援経費 

    石川卓哉

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1000000

  2. 体外式超音波装置を用いた、膵胆肝領域における新式シアウェーブエラストグラフィー技術およびフュージョン技術の臨床有用性の検討の研究

    2018.4 - 2019.3

    フィリップス・ジャパン共同研究助成 

    石川卓哉

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\500000

  3. 膵がん患者におけるGd-EOB-DTPA造影MRIと比較した肝転移に対する造影超音波検査の有用性の研究

    2018.4 - 2019.3

    中京長寿医療研究推進財団医学研究助成 

    石川卓哉

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\500000

  4. 自己免疫性膵炎の診断におけるEUS-FNB の有用性に関する多施設共同研究

    2017.4 - 2019.3

    Boston Scientific Corporation医師主導研究支援プログラム 

    石川卓哉

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\560000

KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. 膵IPMNにおけるCFTR遺伝子変異と悪性化の関係解明および治療応用

    Grant number:24K22118  2024.6 - 2027.3

    科学研究費助成事業  挑戦的研究(萌芽)

    川嶋 啓揮, 山口 淳平, 石川 卓哉, 飯田 忠, 水谷 泰之, 山本 明子, 石黒 洋

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    Authorship:Coinvestigator(s) 

    膵IPMN診療の現状は、経過観察による悪性化の早期発見が精一杯であり予防法は皆無である。日常臨床において悪性化予防法に対する患者の要望は非常に強い。一方、CFTR遺伝子変異は膵のう胞を形成することが多いのう胞繊維症の原因である。我々は、ヒトの正常な膵管ではCFTRが発現している一方、IPMN症例ではその発現が低下していることを確認した。このことが、膵液内の重炭酸イオンの濃度を下げ、のう胞内ムチンの粘調度を上げ、IPMNの悪性化や異所性PDAC発現の原因になっているという仮説を立てた。本研究は、このCFTR遺伝子変異とIPMN悪性化の関連を基礎的に検討することである。

  2. 膵腫瘍内pH調整による間質変容誘導療法の開発

    Grant number:24K11067  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    飯田 忠, 石川 卓哉, 川嶋 啓揮

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    膵がんに代表される難治がんは化学療法に対して抵抗性があることは有名である。この原因としてがん関連線維芽細胞(以下CAF)が関与しており、近年の研究によりCAFは単一な細胞集団ではなく、化学療法抵抗性の微小環境を形成するCAFと化学療法感受性の微小環境を形成するCAFが混在している。また、腫瘍内の微小環境は低酸素、低pH、低栄養等が報告されており、これらの環境がCAFへの形質変化にどのような作用を及ぼすかは未だ明らかとなっていない。本研究の目的は腫瘍内微小環境の中でもpHに着目しCAFの形質変化への作用を検証すると同時に、さらにはここで得られた知見を治療応用に結びつけることである。

  3. Optimization of Tissue Sampling Methods and Development of Personalized Medicine Based on Fibroblast Diversity in Pancreatic Cancer

    Grant number:23K07374  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator 

    Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )

  4. 膵癌早期診断を目的とした、IPMNの病変及び周囲背景膵における遺伝子変異解析

    Grant number:22K08010  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    大野 栄三郎, 石川 卓哉, 加藤 あす香, 川嶋 啓揮, 西田 一貴, 飯田 忠, 水谷 泰之

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    膵癌早期診断は喫緊の課題であるが、未だに高リスク群の絞り込みは不十分である。膵管内乳頭粘液性腫瘍(IPMN)は自身の悪性化に加え、通常型膵癌が高頻度に発生すると報告されている。本研究では、サーベイランス中の膵嚢胞症例中、手術例(膵癌または悪性IPMN疑い)における、切除病変の遺伝子変異プロファイルと周囲正常膵実質内の膵管上皮内腫瘍性病変(PanIN)の発症頻度および背景膵実質内膵管上皮における遺伝子変異プロファイルを同時に解析し、IPMN症例における膵管癌発生の超高リスク群の特徴を解明する。更にその結果を蓄積された臨床情報、画像情報、血液検体と対比し、膵発癌予測の新規バイオマーカーを探索する。
    膵管内乳頭粘液性腫瘍(IPMN)は粘液産生を特徴とする膵上皮性腫瘍で緩徐に進行するものと報告されているが、同時に浸潤性膵管癌発症の危険因子ともされている。近年IPMN症例にIPMNとは別病変として浸潤性膵管癌が発症(IPMN併存膵癌と呼称)することも知られており、特に既存のIPMNの近傍より発症した浸潤癌はIPMN由来浸潤癌であるのかIPMN近傍より発症した浸潤性膵管癌であるのかの鑑別は難しい。我々はIPMN症例の中に、背景膵において膵発癌(併存膵癌)のハイリスクとなる前がん病変および遺伝子バリアントを発症する群が存在するとの仮説をもとに、IPMNに併存する浸潤性膵管癌(IPMN併存膵癌)にて切除を実施した症例(A群)、IPMN由来癌にて切除した症例(B群)、浸潤性膵管癌にて切除を行い、その背景膵にIPMNを認めない症例(C群)の各症例における、臨床的背景、術前画像所見、特に超音波内視鏡による背景膵所見、病理学的な背景膵における異型膵管上皮の分布、膵がんの主病巣部および十分に主病変部から離れた膵断端部位の背景膵における遺伝子プロファイルの特徴の対比を目的に研究をすすめている。
    本年度はA群、B群、C群の症例の抽出(各20症例)を選別し、それらの臨床病理学的な背景因子の抽出、術前画像所見(特に造影CTとEUSによる主病変部の特徴と断端部における画像所見)、切除病理標本における切除断端部における病理所見の解析を実施した。その結果、IPMN併存膵癌症例においては、膵断端部に画像上認識が困難であったIPMN病変または膵上皮内腫瘍性病変(PanIN)病変がIPMN由来癌およびIPMNを併存しない浸潤性膵管癌症例に比べて高頻度に認められるという知見を得た。
    研究代表者の移籍から症例の選別、レーザーマイクロダイセクション(LMD)から組織DNA抽出、シークエンスの実施環境準備に時間を要しているが、下記のごとく研究を推進している。
    本年度はA群、B群、C群の症例の抽出(各20症例)を選別し、1)それらの臨床病理学的な背景因子の抽出、術前画像所見(特に造影CTとEUSによる主病変部の特徴と断端部における画像所見)、2)切除病理標本における切除断端部における病理所見の解析を実施した。
    その結果、IPMN併存膵癌症例においては、膵断端部に画像上認識が困難であった膵癌ハイリスク所見(IPMN病変または膵上皮内腫瘍性病変(PanIN)病変)がIPMN由来癌およびIPMNを併存しない浸潤性膵管癌症例に比べて高頻度に認められる知見を得た。(病理所見の具体的な数値表記)
    また術前の画像診断においては断端部領域における背景膵実質の超音波内視鏡による所見においてIPMN併存膵癌(A群)においては、早期慢性膵炎所見を30.7%(B群では10.5%, C群では8.3%)と有意に高い頻度で検出されていた。
    一方臨床的背景との対比において、背景膵に膵癌ハイリスク所見を有する症例の診断時における耐糖能、膵癌家族歴には相関を認めていない。(いずれも論文未発表)
    現在研究の主目的である、膵切除例の背景膵の膵管上皮における遺伝子プロファイル解析の開始にむけ、組織未染色標本の作製、レーザーマイクロダイセクション(LMD)から組織DNA抽出、シークエンスの準備を進めている。主研究者の移籍にともない、LMD作業にやや遅延が生じているが、外注委託により研究を遂行する予定である。
    またその遺伝子プロファイル所見と照合するため、より詳細な病理組織所見および術前の画像における背景膵所見の定量的解析(具体的には造影EUSにおける造影様式の解析、EUS elastographyのパターン、Strain Ratioによる組織硬度定量化、Bモード所見のヒストグラム解析など、CTの造影パターン、CT、MRIによる背景膵脂肪化解析)を並行して実施する予定である。
    順調に解析が進めば、IPMN前向き観察研究参加症例にて切除を行った症例におけるこれまでの臨床経過・画像所見経過との対比を行い、IPMN症例における特に膵癌ハイリスク因子を有する患者群の抽出に有用なキー所見(画像所見・臨床背景)の発見を目指したい。

  5. 胆膵疾患の十二指腸主乳頭擦過採取による表在細菌叢プロファイル作成と臨床応用の探索

    Grant number:21K19897  2021.7 - 2025.3

    科学研究費助成事業  挑戦的研究(萌芽)

    川嶋 啓揮, 大野 栄三郎, 石川 卓哉, 飯田 忠, 中村 正直

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    本研究の目的は、胆膵疾患の十二指腸主乳頭(PV)のブラシ擦過採取による表層細菌叢プロファイル作成と将来の基礎研究・臨床応用の可能性を探索することである。Fusobacterium nucleatumと大腸癌の関連が報告され、膵癌についても腫瘍内細菌の存在が明らかとなり注目されている。しかし、膵癌以外の胆膵疾患に関する報告は乏しい。PVは胆管・膵管が開口し、病変を通過した胆汁・膵液にさらされており、直視下に低侵襲でサンプル採取出来る特徴をもつ。本研究はPV擦過採取による細菌叢解析を行い今後の胆膵疾患の表層細菌叢、手術検体による病変内細菌叢、PV表層細菌叢と臨床所見を比較検討できるかを探索する。
    本研究の目的は、胆膵疾患の十二指腸主乳頭(PV)のブラシ擦過採取による表層細菌叢プロファイル作成と将来の基礎研究・臨床応用の可能性を探索することである。膵癌についても腫瘍内細菌の存在が明らかとなり注目されている。しかし、膵癌以外の胆膵疾患に関する報告は乏しい。PVは胆管・膵管が開口し、病変を通過した胆汁・膵液にさらされており、直視下に低侵襲でサンプル採取出来る特徴をもつ。本研究はPV擦過採取による細菌叢解析を行い今後の胆膵疾患の表層細菌叢、手術検体による病変内細菌叢、PV表層細菌叢と臨床所見を比較検討できるかを探索する。
    2023年度までに乳頭部腺腫23例、乳頭部癌16例、胆管癌39例、膵管狭窄症例10例に同意を取得し、サンプル採取を行った。乳頭部癌と腺腫では菌種に有意差が認められ、一部、大腸がんなど他の癌での増加が指摘されている菌種の増加が指摘され、α多様性にも有意差が認められることが確認された。胆管癌症例の乳頭部擦過による菌叢解析は可能であるが、他疾患との有意な差異は認められなかった。胆管狭窄部の検討においては、41例に施行し、擦過回数を増やすなどの工夫をすることにより胆管病変部のNGS解析可能率が60%程度まで改善したが現在の症例数では良悪性疾患の有意な差は認めなかった。胆汁、膵液については15例にNGS解析を行い解析率は50%程度であった。膵腫瘍に対する穿刺生検(FNA)検体におけるNGS解析可能率は11例に行い50%程度であった。これまでにPVと胆管病変表層、膵腫瘍内、胆汁、膵液には細菌叢が存在しており、PVにおいては腺癌症例の菌種が有意に異なることより明確になった。
    2024年度は、NGS可能であった検体を対象に遅れている解析を進め論文化を進める。これらにより胆膵の発癌メカニズムの解析につながるような次なる基礎的発展研究の可能性も模索する。
    症例数の蓄積は順調に進行した。NGS解析は症例蓄積の後に行うために解析するまでに時間がかかり、その後の解析まで進むのに時間を要している。一定の症例蓄積は行ったので、これまで得られた知見を論文化するとともに、他研究で得られている他疾患の細菌叢との差異や治療反応性の違いなどの解析を進めていく。膵癌などのFNA検体は症例数が少ないため、さらに症例を蓄積してNGS解析を進めることにより新たな知見が得られることに期待している。
    乳頭部腫瘍については大腸や他の消化器疾患、糞便の細菌叢との比較なども考慮していく。胆管病変については、疾患による細菌叢の差異を認めることは困難と考えられ治療反応性など他の方面から解析を進める。膵疾患に対するFNA検体の採取・解析数の増加を予定している。

  6. 免疫チェックポイント阻害剤抵抗性を改善する革新的膵癌治療法の開発

    Grant number:21K07941  2021.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    飯田 忠, 大野 栄三郎, 石川 卓哉, 川嶋 啓揮, 藤城 光弘

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    膵がんに代表される難治がんは免疫チェックポイント阻害剤(以下ICI)に対して抵抗性であり、その原因としてCAFが重要な役割を担っている。近年の研究によりCAFを促進性から抑制性にリプログラム(CAF初期化)させることで抵抗性が改善される可能性が示唆されているがその有効性に関しては明らかとなっていない。我々はMeflinを指標とすることでCAF初期化薬の候補薬を既に同定しており、本研究ではこれらの薬剤とICIとの併用効果を検証し、間質をターゲットとした革新的新規治療法の確立を目指す。
    本研究ではAM80と免疫チェックポイント阻害剤との併用による腫瘍縮小効果の検証、非臨床検体を用いたAM80による免疫プロファイルの変化と作用機序の解明、さらには臨床検体を用いたAM80による免疫プロファイルの変化の検証を行う予定である。今年度は膵癌、尿路上皮癌、胃癌、肺癌のマウスモデルに対してICI(抗PD-1抗体あるいは抗PD-L1抗体)とAM80との併用による有効性を確認することができた。また、一細胞解析を用いたところAM80投与群はAM80非投与群と比べ、リンパ球、マクロファージにおいて変化が見られ、特にマクロファージの変化がICI感受性を増強していることが判明した。さらに一細胞解析だけでなく、免疫染色やフローサイトメトリーを使用して追加で検証する予定である。また、この免疫細胞の変化がCAFを介しての作用であるかどうか、その場合のメカニズムに関しても確認し現在再現性を確認しているところである。
    臨床試験に向けては、非臨床性の充足性に関してレギュラトリーサイエンス戦略相談事前面談を行った。結果、AM80とICIの併用の臨床試験を実施することについて追加の非臨床安全性試験が必要か確認したが、特に追加は不要であるとの回答を得て尿路上皮癌に関しての治験計画を行っている。膵癌に関しては特定臨床試験を計画し各種書類を作成した。2024年2月には先進医療Bの認可、3月にはEDC構築も終了し令和6年度4月より開始する予定である。
    本研究ではAM80と免疫チェックポイント阻害剤との併用による腫瘍縮小効果の検証、非臨床検体を用いたAM80による免疫プロファイルの変化と作用機序の解明、さらには臨床検体を用いたAM80による免疫プロファイルの変化の検証を行う予定である。今年度は膵癌、尿路上皮癌、胃癌、肺癌のマウスモデルに対してICI(抗PD-1抗体あるいは抗PD-L1抗体)とAM80との併用による有効性を確認できた。また、一細胞解析を用いAM80投与群はAM80非投与群と比べ、リンパ球、マクロファージにおいて変化が見られ、特にマクロファージの変化がICI感受性を増強していることが判明した。さらに一細胞解析だけでなく、免疫染色やフローサイトメトリーを使用して追加で検証し同様な変化を確認することができている。
    臨床試験に向けては、非臨床性の充足性に関してレギュラトリーサイエンス戦略相談事前面談を行った。結果、AM80とICIの併用の臨床試験を実施することについて追加の非臨床安全性試験が必要か確認したが、特に追加は不要であるとの回答を得て尿路上皮癌に関しての治験計画を行っている。膵癌に関しては特定臨床試験を計画し各種書類を作成した。2024年2月には先進医療Bの認可、3月にはEDC構築も終了し令和6年度4月より開始する予定である。
    AM80投与群はAM80非投与群と比べ、リンパ球、マクロファージにおいて変化が見られ、特にマクロファージの変化がICI感受性を増強していることが判明した。次年度はさらに臨床検体を用いて検証する予定である。

  7. Clinical Application of Artificial Intelligence to Improve Diagnostic Performance of Endoscopic Ultrasound for Pancreatic Diseases

    Grant number:20K12689  2020.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator 

    Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )

  8. The clinicopathological analysis of pancreatic cancer from the viewpoint of tissue elasticity measured by EUS elastography

    Grant number:18K12054  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ohno Eizaburo

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    In this research project, we researched to establish a method for measuring "tissue elasticity" in pancreatic cancer(PC) by EUS elastography and to elucidate the relationship between "elasticity" and the biological behavior and molecular biological characteristics of PC. EUS-shear wave elastography, a novel elasticity measurement tool, showed instability in measurement, and the Strain elastography method with histogram analysis showed feasible results in the evaluation of elasticity of pancreatic tumor. In the relationship between the clinicopathological features of PC and tissue elasticity, high-elasticity ”Hard” PCs showed significantly poor prognosis after surgical resection, and even in unresectable PC cases, it correlated with the duration of response to specific anticancer drug treatment.
    Currently, we are analyzing the gene mutation of PC and CAFs to investigate the correlated factors in histopathological specimens of PCs.

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