Updated on 2025/03/04

写真a

 
ICHIYANAGI Kenji
 
Organization
Graduate School of Bioagricultural Sciences Department of Animal Sciences Professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences Department of Bioresource Sciences
Title
Professor
Profile
2000 Ph.D. Graduate School of Science, Osaka University, Japan


2000-2002 Post-doc, Wadsworth Center, NY State Department of Health, USA
2002-2003 Post-doc, The University of Tokyo, Japan
2003-2007 Assistant Professor, Tokyo Institute of Technology, Japan
2007-2010 Assistant Professor, National Institute of Genetics, Japan
2010-2014 Assistant Professor, Kyushu University, Japan
2014-2016 Associate Professor, Kyushu University, Japan
2016-present Professor, Nagoya University, Japan
External link

Degree 1

  1. Ph. D ( 2000.3   Osaka University ) 

Research Interests 12

  1. 哺乳類

  2. piRNA

  3. ヒストン修飾

  4. DNAメチル化

  5. 相同DNA組み換え

  6. 減数分裂

  7. 精子形成過程

  8. レトロトランスポゾン

  9. ゲノム進化

  10. エピゲノム

  11. エピジェネティクス

  12. transgenerational epigenetic inheritance

Research Areas 4

  1. Others / Others  / Epigenetics

  2. Life Science / Genome biology

  3. Life Science / Molecular biology

  4. Life Science / Genetics

Current Research Project and SDGs 4

  1. 糖尿病による生殖細胞エピゲノム異常とその遺伝性

  2. 哺乳類のエピゲノム進化機構

  3. 減数分裂組み換えのエピジェネティック制御

  4. レトロトランスポゾンのエピジェネティック制御機構

Research History 7

  1. Nagoya University   Graduate School of Bioregulation   Professor

    2016.7

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    Country:Japan

  2. Kyushu University   Medical Institute of Bioregulation   Associate professor

    2014.7 - 2016.6

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    Country:Japan

  3. Kyushu University   Medical Institute of Bioregulation   Associate Professor

    2010.4 - 2014.6

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    Country:Japan

  4. National Institute of Genetics   Division of Human Genetics   Associate Professor

    2007.4 - 2010.3

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    Country:Japan

  5. Tokyo Institute of Technology   Graduate School of Bioscience and Biotechnology   Associate Professor

    2003.4 - 2007.3

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    Country:Japan

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Education 2

  1. Osaka University   Graduate School, Division of Natural Science

    - 2000.3

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    Country: Japan

  2. Nagoya University   Faculty of Science

    - 1994.3

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    Country: Japan

Professional Memberships 4

  1. 日本エピジェネティクス研究会   幹事

  2. 日本分子生物学会   会員

  3. 日本遺伝学会   幹事、全国評議員、男女共同参画委員会委員長

  4. 日本進化学会   会員

Committee Memberships 2

  1. 日本遺伝学会   男女共同参画委員会 委員長  

    2021.4   

  2. 日本遺伝学会   男女共同参画委員会  

    2012.4   

Awards 1

  1. 日本遺伝学会奨励賞

    2012.9   日本遺伝学会   レトロトランスポゾンの転移機構および宿主との相互作用に関する研究

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

 

Papers 48

  1. Insertion of short L1 sequences generates inter-strain histone acetylation differences in the mouse

    Boyboy, BAG; Ichiyanagi, K

    MOBILE DNA   Vol. 15 ( 1 ) page: 11   2024.5

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  2. The sixth Japanese meeting on biological function and evolution through interactions between hosts and transposable elements

    Ichiyanagi, K; Ikeda, Y; Saito, K

    MOBILE DNA   Vol. 14 ( 1 ) page: 22   2023.12

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  3. Mouse retrotransposons: sequence structure, evolutionary age, genomic distribution and function

    Kawase, M; Ichiyanagi, K

    GENES & GENETIC SYSTEMS   Vol. 98 ( 6 ) page: 337 - 351   2023.11

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  4. Diversity and evolution of highly repetitive DNA sequences constituting chromosome-site specific heterochromatin in two Gerbillinae species

    Uno, Y; Matsubara, K; Inoue, J; Inazawa, J; Shinohara, A; Koshimoto, C; Ichiyanagi, K; Matsuda, Y

    CYTOGENETIC AND GENOME RESEARCH   Vol. 163 ( 1-2 ) page: 42 - 51   2023.11

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  5. C3H/HeNSlc mouse with low phospholipid transfer protein expression showed dyslipidemia.

    Kobayashi M, Kanbe F, Ishii R, Tsubouchi H, Hirai K, Miyasaka Y, Ohno T, Oda H, Ikeda S, Katoh H, Ichiyanagi K, Ishikawa A, Murai A, Horio F

    Scientific reports   Vol. 13 ( 1 ) page: 13813   2023.8

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    Language:English  

    DOI: 10.1038/s41598-023-40917-9

    PubMed

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Books 4

  1. 遺伝学の百科事典 継承と多様性の源

    ( Role: Joint editor)

    丸善出版  2022.1  ( ISBN:978-4621306604

  2. 改訂 遺伝単

    日本遺伝学会( Role: Edit)

    エヌ・ティー・エス  2021.3  ( ISBN:978-4860437121

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    Total pages:456   Book type:Textbook, survey, introduction

  3. ヒトゲノム事典 Reviewed

    斎藤成也(編集委員長)( Role: Joint author ,  11.1 Roadmap Epigenome Project)

    一色出版  2020.12  ( ISBN:978-4-910389-12-7

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    Total pages:500   Book type:Dictionary, encyclopedia

  4. 遺伝単

    日本遺伝学会( Role: Edit)

    エヌ・ティー・エス  2017.9  ( ISBN:978-4860434991

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    Total pages:372  

Presentations 20

  1. 糖尿病による精子エピゲノム異常と次世代への遺伝性

    一柳 健司、Beverly Boyboy、大塚 大和、一柳 朋子、新田 洋久

    第47回日本分子生物学会  2024.11.27 

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    Event date: 2024.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡  

  2. Epigenetic regulation of retrotransposons during germ cell development in the mouse Invited International conference

    Kenji Ichiyanagi

    Kumamoto Key Forum  2024.11.22  熊本大学

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    Event date: 2024.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:熊本  

  3. エピジェネティクスとトランスポゾンの交差点 Invited

    一柳健司

    香川大学ゲノム・遺伝子源解析センター 月例セミナー  2024.11.15  香川大学

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    Event date: 2024.11

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:高松  

  4. Insertion of short L1 sequences generates inter-strain histone acetylation differences in the mouse

    Kenji Ichiyanagi, Beverly Ann Boyboy

    2024.9.4 

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    Event date: 2024.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  5. ヒトAlu SINEの発現制御機構

    一柳健司

    第17回日本エピジェネティクス研究会  2024.6.13  日本エピジェネティクス研究会

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    Event date: 2024.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪  

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Research Project for Joint Research, Competitive Funding, etc. 8

  1. ビタミンC欠乏による精子エピゲノム異常とその遺伝性

    2023.2 - 2024.5

    研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\5000000 ( Direct Cost: \5000000 )

  2. ビタミンC欠乏による精子エピゲノム異常とその遺伝性

    2022.12 - 2025.3

    研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000 ( Direct Cost: \2000000 )

  3. カイガラムシにおける父性染色体不活性化と性分化の分子機構の解明

    2022.10 - 2023.12

    大幸財団  研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4000000 ( Direct Cost: \4000000 )

  4. 父親の糖尿病状態が子に与えるエピジェネティックな変化の解明

    2020.4 - 2021.9

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    Authorship:Principal investigator 

    Grant amount:\1000000

  5. マウス生殖細胞形成過程の時間軸におけるエピジェネティック制御機構の変化

    2017.11 - 2019.11

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KAKENHI (Grants-in-Aid for Scientific Research) 10

  1. Understanding and experimental validation of epigenome evolution that underlies human-specific neuronal differentiation.

    Grant number:23K18153  2023.6 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship:Principal investigator 

    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

  2. Understanding the biological significance of meiosis in terms of host-retrotransposon interactions.

    Grant number:23H02523  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator 

    Grant amount:\18720000 ( Direct Cost: \14400000 、 Indirect Cost:\4320000 )

  3. Molecular mechanisms for changes in epigenome dynamics that have been involved in human-specific traits

    Grant number:19K22452  2019.6 - 2021.3

    Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship:Principal investigator 

    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

  4. Epigenetic regulatory network for retrotransposon silencing during germ cell development

    Grant number:16H04817  2016.4 - 2019.3

    Ichiyanagi Kenji

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    Authorship:Principal investigator 

    Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )

    Regulation of the transposable activity of millions of copies of retrotransposons is important for maintaining the genomic integrity. We have revealed that DNA methylation is an important epigenetic modification to transcriptionally silence the retrotransposons and that piRNAs play an important role in post-transcriptional silencing of retrotransposons. Interestingly, in the early stage of germ cell development (prospermatogonia), piRNAs play a dominant role, whereas DNA methylation becomes more important in the later stage (spermatocytes). We investigated retrotransposon expression by strand-specific mRNA-seq of prospermatogonia, spermatogonia, and spermatocytes of wild-type, Dnmt3L, and Pld6 mutant mice. The results showed that the shift from the piRNA-centered to DNA methylation-centered regulatory systems occurs gradually during development. Moreover, ChIP-seq analysis of spermatogonia revealed that H3K9me3 modification at retrotransposons depends on DNA methylation.

  5. Development of a method for medium-length RNA, and functional analysis of SINE non-coding RNAs

    Grant number:16K14784  2016.4 - 2019.3

    Ichiyanagi Kenji

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    Authorship:Principal investigator 

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    No technique was available to comprehensively analyze the expression levels of RNAs of medium length, such as tRNA, 5S rRNA, spiceosomal RNA, and SINE RNA. In this study, we have developed a protocol to do this, which we designated as meRNA-seq. The protocol involves processing of the 5’ end of RNAs by the RppH enzyme to make a monophosphated end, specific adaptor ligation to the 5’ and 3’ ends, respectively, PCR, and deep sequencing on Illumina MiSeq in a single-end sequencing mode of 300 bp. We then focused on SINE RNA expression, and revealed that SINEs show tissue-specific expression pattern with very high expression in spermatogonia (male germ cells). Interestingly, even in spermatogonia, loss of DNA methylation or piRNA resulted in upregulation of SINEs, suggesting that SINE transcription by RNA polymerase III is epigenetically regulated.

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Teaching Experience (On-campus) 14

  1. 資源生物科学基盤実験実習

    2021

  2. 資源生物科学基盤実験実習

    2020

  3. 資源生物科学実験実習

    2020

  4. 生物情報処理演習

    2020

  5. 分子細胞生物学1

    2020

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Teaching Experience (Off-campus) 1

  1. エピジェネティクス特論

    2019.11 Kyushu University)

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    Level:Postgraduate 

 

Academic Activities 2

  1. 編集委員 International contribution

    Genes and Genetic Systems  2017.1

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    Type:Peer review 

  2. 編集委員

    Mobile DNA  2014.1

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    Type:Peer review