Updated on 2024/03/20

写真a

 
ICHIYANAGI Kenji
 
Organization
Graduate School of Bioagricultural Sciences Department of Animal Sciences Professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences Department of Bioresource Sciences
Title
Professor
Profile
2000 Ph.D. Graduate School of Science, Osaka University, Japan


2000-2002 Post-doc, Wadsworth Center, NY State Department of Health, USA
2002-2003 Post-doc, The University of Tokyo, Japan
2003-2007 Assistant Professor, Tokyo Institute of Technology, Japan
2007-2010 Assistant Professor, National Institute of Genetics, Japan
2010-2014 Assistant Professor, Kyushu University, Japan
2014-2016 Associate Professor, Kyushu University, Japan
2016-present Professor, Nagoya University, Japan
External link

Degree 1

  1. Ph. D ( 2000.3   Osaka University ) 

Research Interests 12

  1. 哺乳類

  2. piRNA

  3. ヒストン修飾

  4. DNAメチル化

  5. 相同DNA組み換え

  6. 減数分裂

  7. 精子形成過程

  8. レトロトランスポゾン

  9. ゲノム進化

  10. エピゲノム

  11. エピジェネティクス

  12. transgenerational epigenetic inheritance

Research Areas 4

  1. Others / Others  / Epigenetics

  2. Life Science / Genome biology

  3. Life Science / Molecular biology

  4. Life Science / Genetics

Current Research Project and SDGs 4

  1. 糖尿病による生殖細胞エピゲノム異常とその遺伝性

  2. 哺乳類のエピゲノム進化機構

  3. 減数分裂組み換えのエピジェネティック制御

  4. レトロトランスポゾンのエピジェネティック制御機構

Research History 7

  1. Nagoya University   Graduate School of Bioregulation   Professor

    2016.7

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    Country:Japan

  2. Kyushu University   Medical Institute of Bioregulation   Associate professor

    2014.7 - 2016.6

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    Country:Japan

  3. Kyushu University   Medical Institute of Bioregulation   Associate Professor

    2010.4 - 2014.6

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    Country:Japan

  4. National Institute of Genetics   Division of Human Genetics   Associate Professor

    2007.4 - 2010.3

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    Country:Japan

  5. Tokyo Institute of Technology   Graduate School of Bioscience and Biotechnology   Associate Professor

    2003.4 - 2007.3

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    Country:Japan

  6. The University of Tokyo   Institute of Molecular and Cellular Bioscience   post-doc

    2002.6 - 2003.3

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    Country:Japan

  7. Wadsworth Center, New York State Department of Health   Division of Genetic Disorders   post-doc

    2000.4 - 2002.5

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    Country:United States

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Education 2

  1. Osaka University   Graduate School, Division of Natural Science

    - 2000.3

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    Country: Japan

  2. Nagoya University   Faculty of Science

    - 1994.3

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    Country: Japan

Professional Memberships 3

  1. 日本エピジェネティクス研究会   幹事

  2. 日本分子生物学会   会員

  3. 日本遺伝学会   幹事、全国評議員、男女共同参画委員会委員長

Committee Memberships 2

  1. 日本遺伝学会   男女共同参画委員会 委員長  

    2021.4   

  2. 日本遺伝学会   男女共同参画委員会  

    2012.4   

Awards 1

  1. 日本遺伝学会奨励賞

    2012.9   日本遺伝学会   レトロトランスポゾンの転移機構および宿主との相互作用に関する研究

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

 

Papers 47

  1. The sixth Japanese meeting on biological function and evolution through interactions between hosts and transposable elements

    Ichiyanagi, K; Ikeda, Y; Saito, K

    MOBILE DNA   Vol. 14 ( 1 ) page: 22   2023.12

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  2. Mouse retrotransposons: sequence structure, evolutionary age, genomic distribution and function

    Kawase, M; Ichiyanagi, K

    GENES & GENETIC SYSTEMS   Vol. 98 ( 6 ) page: 337 - 351   2023.11

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  3. Diversity and evolution of highly repetitive DNA sequences constituting chromosome-site specific heterochromatin in two Gerbillinae species

    Uno, Y; Matsubara, K; Inoue, J; Inazawa, J; Shinohara, A; Koshimoto, C; Ichiyanagi, K; Matsuda, Y

    CYTOGENETIC AND GENOME RESEARCH   Vol. 163 ( 1-2 ) page: 42 - 51   2023.11

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  4. C3H/HeNSlc mouse with low phospholipid transfer protein expression showed dyslipidemia.

    Kobayashi M, Kanbe F, Ishii R, Tsubouchi H, Hirai K, Miyasaka Y, Ohno T, Oda H, Ikeda S, Katoh H, Ichiyanagi K, Ishikawa A, Murai A, Horio F

    Scientific reports   Vol. 13 ( 1 ) page: 13813   2023.8

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    Language:English  

    DOI: 10.1038/s41598-023-40917-9

    PubMed

  5. Sequence Divergence and Retrotransposon Insertion Underlie Interspecific Epigenetic Differences in Primates

    Hirata, M; Ichiyanagi, T; Katoh, H; Hashimoto, T; Suzuki, H; Nitta, H; Kawase, M; Nakai, R; Imamura, M; Ichiyanagi, K

    MOLECULAR BIOLOGY AND EVOLUTION   Vol. 39 ( 10 )   2022.10

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  6. The Expression Dynamics of piRNAs Derived From Male Germline piRNA Clusters and Retrotransposons

    Kawase, M; Ichiyanagi, K

    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY   Vol. 10   page: 868746   2022.5

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  7. Potential role of KRAB-ZFP binding and transcriptional states on DNA methylation of retroelements in human male germ cells

    Fukuda, K; Makino, Y; Kaneko, S; Shimura, C; Okada, Y; Ichiyanagi, K; Shinkai, Y

    ELIFE   Vol. 11   2022.3

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  8. The regulatory mechanisms that make mature sperm cells in the mouse

    Ichiyanagi, K

    GENES & GENETIC SYSTEMS   Vol. 97 ( 1 ) page: 1 - 1   2022.2

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  9. The fifth Japanese meeting on biological function and evolution through interactions between hosts and transposable elements

    Ichiyanagi, K; Saito, K

    MOBILE DNA   Vol. 13 ( 1 ) page: 3   2022.1

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  10. TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication

    Inatomi, T; Matsuda, S; Ishiuchi, T; Do, Y; Nakayama, M; Abe, S; Kasho, K; Wanrooij, S; Nakada, K; Ichiyanagi, K; Sasaki, H; Yasukawa, T; Kang, D

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH   Vol. 1869 ( 1 ) page: 119167   2022.1

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  11. Quantitative Separation of Precipitation and Permafrost Waters Used for Evapotranspiration in a Boreal Forest: A Numerical Study Using Tracer Model

    Park, H; Tanoue, M; Sugimoto, A; Ichiyanagi, K; Iwahana, G; Hiyama, T

    JOURNAL OF GEOPHYSICAL RESEARCH-BIOGEOSCIENCES   Vol. 126 ( 12 )   2021.12

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    Language:Japanese  

    DOI: 10.1029/2021JG006645

    Web of Science

  12. melRNA-seq for Expression Analysis of SINE RNAs and Other Medium-Length Non-Coding RNAs

    Mori, Y; Ichiyanagi, K

    MOBILE DNA   Vol. 12 ( 1 ) page: 15   2021.6

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  13. B2 SINE Copies Serve as a Transposable Boundary of DNA Methylation and histone Modifications in the Mouse

    Ichiyanagi, T; Katoh, H; Mori, Y; Hirafuku, K; Boyboy, BA; Kawase, M; Ichiyanagi, K

    MOLECULAR BIOLOGY AND EVOLUTION   Vol. 38 ( 6 ) page: 2380 - 2395   2021.6

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  14. Dispersal history of <i>Miniopterus fuliginosus</i> bats and their associated viruses in east Asia

    Kimprasit, T; Nunome, M; Iida, K; Murakami, Y; Wong, ML; Wu, CH; Kobayashi, R; Hengjan, Y; Takemae, H; Yonemitsu, K; Kuwata, R; Shimoda, H; Si, LF; Sohn, JH; Asakawa, S; Ichiyanagi, K; Maeda, K; Oh, HS; Mizutani, T; Kimura, J; Iida, A; Hondo, E

    PLOS ONE   Vol. 16 ( 1 ) page: e0244006   2021.1

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  15. Combined deletions of <i>IHH</i> and <i>NHEJ1</i> cause chondrodystrophy and embryonic lethality in the Creeper chicken

    Kinoshita, K; Suzuki, T; Koike, M; Nishida, C; Koike, A; Nunome, M; Uemura, T; Ichiyanagi, K; Matsuda, Y

    COMMUNICATIONS BIOLOGY   Vol. 3 ( 1 ) page: 144   2020.3

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  16. Non-transmissible MV Vector with Segmented RNA Genome Establishes Different Types of iPSCs from Hematopoietic Cells

    Hiramoto, T; Tahara, M; Liao, JY; Soda, Y; Miura, Y; Kurita, R; Hamana, H; Inoue, K; Kohara, H; Miyamoto, S; Hijikata, Y; Okano, S; Yamaguchi, Y; Oda, Y; Ichiyanagi, K; Toh, H; Sasaki, H; Kishi, H; Ryo, A; Muraguchi, A; Takeda, M; Tani, K

    MOLECULAR THERAPY   Vol. 28 ( 1 ) page: 129 - 141   2020.1

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  17. Characterization of genetic-origin-dependent monoallelic expression in mouse embryonic stem cells

    Ohishi, H; Yeung, WKA; Unoki, M; Ichiyanagi, K; Fukuda, K; Maenohara, S; Shirane, K; Chiba, H; Sado, T; Sasaki, H

    GENES TO CELLS   Vol. 25 ( 1 ) page: 54 - 64   2020.1

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  18. Selective Reduction Mechanism of Graphene Oxide Driven by the Photon Mode <i>versus</i> the Thermal Mode

    Hada, M; Miyata, K; Ohmura, S; Arashida, Y; Ichiyanagi, K; Katayama, I; Suzuki, T; Chen, W; Mizote, S; Sawa, T; Yokoya, T; Seki, T; Matsuo, J; Tokunaga, T; Itoh, C; Tsuruta, K; Fukaya, R; Nozawa, S; Adachi, S; Takeda, J; Onda, K; Koshihara, S; Hayashi, Y; Nishina, Y

    ACS NANO   Vol. 13 ( 9 ) page: 10103 - 10112   2019.9

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  19. Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring

    Inoguchi, Y; Ichiyanagi, K; Ohishi, H; Maeda, Y; Sonoda, N; Ogawa, Y; Inoguchi, T; Sasaki, H

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 10181   2019.7

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  20. Novel roles of Drosophila FUS and Aub responsible for piRNA biogenesis in neuronal disorders.

    Wakisaka KT, Tanaka R, Hirashima T, Muraoka Y, Azuma Y, Yoshida H, Tokuda T, Asada S, Suda K, Ichiyanagi K, Ohno S, Itoh M, Yamaguchi M

    Brain research   Vol. 1708   page: 207 - 219   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.brainres.2018.12.028

    Web of Science

    PubMed

  21. TE studies in Japan: the fourth Japanese meeting on host-transposon interactions

    Ichiyanagi, K; Saito, K

    MOBILE DNA   Vol. 10   page: 11   2019.3

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  22. Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA

    Matsuda Shigeru, Yasukawa Takehiro, Sakaguchi Yuriko, Ichiyanagi Kenji, Unoki Motoko, Gotoh Kazuhito, Fukuda Kei, Sasaki Hiroyuki, Suzuki Tsutomu, Kang Dongchon

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 5801   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-24251-z

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  23. Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis

    Kuroki Shunsuke, Nakai Yuji, Maeda Ryo, Okashita Naoki, Akiyoshi Mika, Yamaguchi Yutaro, Kitano Satsuki, Miyachi Hitoshi, Nakato Ryuichiro, Ichiyanagi Kenji, Shirahige Katsuhiko, Kimura Hiroshi, Shinkai Yoichi, Tachibana Makoto

    STEM CELL REPORTS   Vol. 10 ( 4 ) page: 1340 - 1354   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.stemcr.2018.02.002

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  24. Association of zygotic piRNAs derived from paternal P elements with hybrid dysgenesis in Drosophila melanogaster

    Wakisaka Keiko Tsuji, Ichiyanagi Kenji, Ohno Seiko, Itoh Masanobu

    MOBILE DNA   Vol. 9   page: 7   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13100-018-0110-y

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  25. Locus-specific hypomethylation of the mouse IAP retrotransposon is associated with transcription factor-binding sites

    Shimosuga Ken-ichi, Fukuda Kei, Sasaki Hiroyuki, Ichiyanagi Kenji

    MOBILE DNA   Vol. 8   page: 20   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13100-017-0105-0

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  26. Locus-specific hypomethylation of the mouse IAP retrotransposon is associated with transcription factor-binding sites. Reviewed

    Shimosuga KI, Fukuda K, Sasaki H, Ichiyanagi K.

    MOBILE DNA   Vol. 8   page: 20   2017.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13100-017-0105-0.

  27. Diversity of P-element piRNA production among M' and Q strains and its association with P-M hybrid dysgenesis in Drosophila melanogaster. Reviewed

    Wakisaka KT, Ichiyanagi K, Ohno S, Itoh M

    MOBILE DNA   Vol. 8   page: 13   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  28. Diversity of <i>P-</i>element piRNA production among M' and Q strains and its association with P-M hybrid dysgenesis in <i>Drosophila melanogaster</i>

    Wakisaka, KT; Ichiyanagi, K; Ohno, S; Itoh, M

    MOBILE DNA   Vol. 8   page: 13   2017.10

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  29. Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability. Reviewed

    Fukuda K., Inoguchi Y., Ichiyanagi K., Ichiyanagi T., Go Y., Nagano M., Yanagawa Y., Takaesu N., Ohkawa Y., Imai H., and Sasaki H.

    Hum Mol Genet   Vol. 26 ( 18 ) page: 3508 - 3519   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/hmg/ddx236

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  30. Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice. Reviewed

    Inoue K., Ichiyanagi K., Fukuda K., Glinka M., and Sasaki H.

    PLoS Genet   Vol. 13 ( 7 ) page: e1006926   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pgen.1006926

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  31. The genetic diversity of D-loop sequences in eastern bent-winged bats (Miniopterus fuliginosus) living in Wakayama Prefecture, Japan. Reviewed

    Iida K., Kobayashi R., Hengjan Y., Nagata N., Yonemitsu K., Nunome M., Kuwata R., Suzuki K., Ichiyanagi K., Maeda K., OhmoriY., and Hondo E.

    J Vet Med Sci   Vol. 79 ( 6 ) page: 1142 - 1145   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1292/jvms.17-0152

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    PubMed

  32. Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency. Reviewed

      Vol. 102 ( 3 ) page: 454 - 465   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3324/haematol.2016.151043

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    PubMed

  33. Software updates in the Illumina HiSeq platform affect whole-genome bisulfite sequencing. Reviewed

    Toh H., Shirane K., Miura F., Kubo N. Ichiyanagi K., Hayashi K., Saitou M., Suyama M., Ito T., and Sasaki H

    BMC Genomics   Vol. 18 ( 1 ) page: 31   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12864-016-3392-9

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  34. Chd5 regulates MuERV-L/MERVL expression in mouse embryonic stem cells via H3K27me3 modification and histone H3.1/H3.2. Reviewed

      Vol. 117   page: 780-792   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

  35. TE studies in Japan: The third Japanese meeting on host-transposon interactions.

      Vol. 7   2016

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    Authorship:Lead author   Language:English  

    DOI: DOI: 10.1186/s13100-016-0082-8

  36. Regulating Pol III transcription to change Pol II transcriptome. Invited

      Vol. 13   page: 3625-3626   2014

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    Authorship:Lead author   Language:English  

  37. HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse. Reviewed

    Ichiyanagi T., Ichiyanagi K., Ogawa A., Kuramochi-Miyagawa S., Nakano T., Chuma S., Sasaki H., and Udono H.

    Nucleic Acids Res   Vol. 42   page: 11903-11911   2014

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  38. Transposable elements in eukaryotic genomes: epigenetic regulation by the host and functionalization for the host. Reviewed

    Ichiyanagi K.

    Genes Genet Syst   Vol. 88   page: 1   2013

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    Authorship:Lead author   Language:English  

  39. Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients. Reviewed

    Nitta H., Unoki M., Ichiyanagi K., Kosho T., Shigemura T., Takahashi H., Velasco G., Francastel C., Picard C., Kubota T., and Sasaki H.

    J Hum Genet   ( 58 ) page: 455-460   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

  40. Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus. Reviewed

    Yamamoto Y., Watanabe T., Hoki Y., Shirane K., Li Y., Ichiyanagi K., Kuramochi- Miyagawa S., Toyoda A., Fujiyama A., Oginuma M., Suzuki H., Sado T., Nakano T., and Sasaki, H.

    Genome Res   Vol. 23   page: 292-299   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

  41. Identification of both copy number variation-type and constant-type core elements in a large segmental duplication region of the mouse genome. Reviewed

    Umemori J., Mori A., Ichiyanagi K., Uno T., and Koide T.

    BMC Genomics   Vol. 14   page: 455   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

  42. DNA methylation differences between humans and chimpanzees are associated with genetic changes, transcriptional divergence and disease genes. Reviewed

    Fukuda K., Ichiyanagi K.*, Yamada Y., Go Y., Udono T., Wada S., Maeda M., Soejima H., Saitou N., Ito T., and Sasaki H.

    J Hum Genet   Vol. 58   page: 446-454   2013

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  43. Accumulation and loss of non-CpG methylation during male germ-cell development. Reviewed

    Ichiyanagi T., Ichiyanagi K., Miyake M., and Sasaki H.

    Nucleic Acids Res   Vol. 41   page: 738-745   2013

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  44. Epigenetic regulation of transcription and possible functions of mammalian short interspersed elements, SINEs. Reviewed

      Vol. 88   page: 19-29   2013

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    Authorship:Lead author   Language:English  

  45. Inhibition of MspI cleavage activity by hydroxymethylation of the CpG site: A concern for DNA modification studies using restriction endonucleases. Reviewed

    Ichiyanagi K.

    Epigenetics   Vol. 7   page: 131-136   2012

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  46. Locus- and domain-dependent control of DNA methylation at mouse B1 retrotransposons during male germ cell development. Reviewed

    Ichiyanagi K.*, Li Y., Watanabe T., Ichiyanagi T., Fukuda K., Kitayama J., Yamamoto Y., Kuramochi-Miyagawa S., Nakano T., Yabuta Y., Seki Y., Saitou M., and Sasaki H.

    Genome Res   Vol. 21   page: 2058-2066   2011

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  47. Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Reviewed

    Watanabe T., Tomizawa S., Mitsuya K., Totoki Y., Yamamoto Y., Kuramochi-Miyagawa S., Iida N., Hoki Y., Murphy P.J., Toyoda A., Gotoh K., Hiura H., Arima T., Fujiyama A., Sado T., Shibata T., Nakano T., Lin H., Ichiyanagi K., Soloway P. D., and Sasaki H.

    Science   Vol. 332   page: 848-852   2011

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Books 4

  1. 遺伝学の百科事典 継承と多様性の源

    ( Role: Joint editor)

    丸善出版  2022.1  ( ISBN:978-4621306604

  2. 改訂 遺伝単

    日本遺伝学会( Role: Edit)

    エヌ・ティー・エス  2021.3  ( ISBN:978-4860437121

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    Total pages:456   Book type:Textbook, survey, introduction

  3. ヒトゲノム事典 Reviewed

    斎藤成也(編集委員長)( Role: Joint author ,  11.1 Roadmap Epigenome Project)

    一色出版  2020.12  ( ISBN:978-4-910389-12-7

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    Total pages:500   Book type:Dictionary, encyclopedia

  4. 遺伝単

    日本遺伝学会( Role: Edit)

    エヌ・ティー・エス  2017.9  ( ISBN:978-4860434991

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    Total pages:372  

Presentations 12

  1. 霊長類におけるエピゲノム進化過程の解明に向けて Invited

    一柳健司

    第76回日本人類学会大会・第38回日本霊長類学会大会連合大会  2022.9.18  日本人類学会、日本霊長類学会

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    Event date: 2022.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:京都   Country:Japan  

  2. ヒトとチンパンジーiPS細胞間のエピジェネティック差のゲノム要因

    平田真由 、一柳朋子、加藤大和、橋本琢磨、新田洋久、仲井理沙子、今村公紀、一柳健司

    第94回遺伝学会大会  2022.9.15  日本遺伝学会

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  3. 哺乳類におけるレトロトランスポゾンのエピジェネティック制御機構 Invited

    一柳健司

    環境エピゲノミクス研究会  2022.6.18  環境エピゲノミクス研究会

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    Event date: 2022.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:オンライン   Country:Japan  

  4. ヒトとチンパンジーの iPS細胞のエピゲノム比較解析 Invited

    一柳健司

    第50回ホミニゼーション研究会  2022.3.22 

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    Event date: 2022.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

  5. マウスB2 SINEはDNAメチル化とヒストン修飾の「動くバウンダリー」として機能する Invited

    一柳健司

    第44回日本分子生物学会  2021.12.2 

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    Event date: 2021.12

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

  6. ローカスレベルでのSINE RNA発現解析を 可能にするmelRNA-seq法

    一柳健司

    第93回日本遺伝学会大会 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  7. SINE配列によるクロマチン区画化 Invited

    一柳健司

    第5回トランスポゾン研究会  2021.8.27 

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    Event date: 2021.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  8. B2 SINE copies serve as a transposable boundary of DNA methylation and histone modifications in the mouse Invited International conference

    Kenji Ichiyanagi

    FASEB meeting on mobile DNA  2021.6.9 

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    Event date: 2021.6

    Language:English   Presentation type:Oral presentation (general)  

  9. 霊長類iPS細胞を用いたエピゲノム進化の解析

    一柳健司

    第21回日本再生医療学会  2021.3.17 

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    Event date: 2021.3

    Presentation type:Symposium, workshop panel (nominated)  

  10. Paternal Transgenerational Epigenetic Inheritance of Diabetes in Mice

    Beverly Ann G. Boyboy, Tomoko Ichiyanagi, Hirohisa Nitta, Kenji Ichiyanagi

    2020.12.2 

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    Event date: 2020.12

    Language:English   Presentation type:Poster presentation  

  11. マウス雄性生殖細胞発生過程におけるレトロトランスポゾンのエピジェネティッ ク制御機構

    一柳健司 、杉本大空 、川瀬雅貴

    第92回日本遺伝学会年会  2020.9.16 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  12. マウス精母細胞におけるSETDB1による遺伝子トレトロトランスポゾンの転写抑制機構

    川瀬雅貴、杉本大空、一柳健司

    第92回日本遺伝学会大会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

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Research Project for Joint Research, Competitive Funding, etc. 8

  1. ビタミンC欠乏による精子エピゲノム異常とその遺伝性

    2023.2 - 2024.5

    研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\5000000 ( Direct Cost: \5000000 )

  2. ビタミンC欠乏による精子エピゲノム異常とその遺伝性

    2022.12 - 2025.3

    研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000 ( Direct Cost: \2000000 )

  3. カイガラムシにおける父性染色体不活性化と性分化の分子機構の解明

    2022.10 - 2023.12

    大幸財団  研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4000000 ( Direct Cost: \4000000 )

  4. 父親の糖尿病状態が子に与えるエピジェネティックな変化の解明

    2020.4 - 2021.9

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    Authorship:Principal investigator 

    Grant amount:\1000000

  5. マウス生殖細胞形成過程の時間軸におけるエピジェネティック制御機構の変化

    2017.11 - 2019.11

  6. 生活習慣病による生殖細胞のエピジェネティック変化およびゲノム変異の発生機序

    2017.10 - 2021.9

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    Grant type:Other

    Grant amount:\50000000

  7. 生殖細胞形成におけるレトロトランスポゾン制御ネットワークの解明

    2013.4 - 2014.3

  8. マウス雄性生殖細胞形成過程におけるSINEレトロトランスポゾンのDNAメチル化ダイナミクス

    2009.4 - 2010.4

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KAKENHI (Grants-in-Aid for Scientific Research) 10

  1. Understanding and experimental validation of epigenome evolution that underlies human-specific neuronal differentiation.

    Grant number:23K18153  2023.6 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship:Principal investigator 

    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

  2. Understanding the biological significance of meiosis in terms of host-retrotransposon interactions.

    Grant number:23H02523  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator 

    Grant amount:\18720000 ( Direct Cost: \14400000 、 Indirect Cost:\4320000 )

  3. Molecular mechanisms for changes in epigenome dynamics that have been involved in human-specific traits

    Grant number:19K22452  2019.6 - 2021.3

    Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship:Principal investigator 

    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

  4. Epigenetic regulatory network for retrotransposon silencing during germ cell development

    Grant number:16H04817  2016.4 - 2019.3

    Ichiyanagi Kenji

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    Authorship:Principal investigator 

    Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )

    Regulation of the transposable activity of millions of copies of retrotransposons is important for maintaining the genomic integrity. We have revealed that DNA methylation is an important epigenetic modification to transcriptionally silence the retrotransposons and that piRNAs play an important role in post-transcriptional silencing of retrotransposons. Interestingly, in the early stage of germ cell development (prospermatogonia), piRNAs play a dominant role, whereas DNA methylation becomes more important in the later stage (spermatocytes). We investigated retrotransposon expression by strand-specific mRNA-seq of prospermatogonia, spermatogonia, and spermatocytes of wild-type, Dnmt3L, and Pld6 mutant mice. The results showed that the shift from the piRNA-centered to DNA methylation-centered regulatory systems occurs gradually during development. Moreover, ChIP-seq analysis of spermatogonia revealed that H3K9me3 modification at retrotransposons depends on DNA methylation.

  5. Development of a method for medium-length RNA, and functional analysis of SINE non-coding RNAs

    Grant number:16K14784  2016.4 - 2019.3

    Ichiyanagi Kenji

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    Authorship:Principal investigator 

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    No technique was available to comprehensively analyze the expression levels of RNAs of medium length, such as tRNA, 5S rRNA, spiceosomal RNA, and SINE RNA. In this study, we have developed a protocol to do this, which we designated as meRNA-seq. The protocol involves processing of the 5’ end of RNAs by the RppH enzyme to make a monophosphated end, specific adaptor ligation to the 5’ and 3’ ends, respectively, PCR, and deep sequencing on Illumina MiSeq in a single-end sequencing mode of 300 bp. We then focused on SINE RNA expression, and revealed that SINEs show tissue-specific expression pattern with very high expression in spermatogonia (male germ cells). Interestingly, even in spermatogonia, loss of DNA methylation or piRNA resulted in upregulation of SINEs, suggesting that SINE transcription by RNA polymerase III is epigenetically regulated.

  6. Dynamics and regulation of genomic imprinting and DNA methylation

    Grant number:25112010  2013.6 - 2018.3

    Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

    Sasaki Hiroyuki

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    We have studied the profiles and roles of epigenomic modifications involved in genomic imprinting and transposon repression during mammalian gametogenesis and early development. We found that: histone H3K9 methylation, which is known to be important for transposon repression, is essential for germ cell development; the mechanism of transposon repression switches from RNA degradation to DNA methylation during spermatogenesis; the profiles of DNA methylation and gene expression change upon spermatogonial stem cell formation; a factor responsible for DNA methylation maintenance in somatic cells is involved in de novo methylation in oocytes; primordial germ cell-like cells in culture, which provide an important source for biochemical analyses of germ cells, recapitulate the DNA methylation and gene expression profiles of their in vivo counterparts. Our results provide important insights into the genomic and epigenomic regulation of gametogenesis and early development.

  7. エピジェネティック修飾と分子シャペロンによるレトロトランスポゾンの制御機構

    Grant number:25503003  2013.4 - 2016.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  8. マウス生殖細胞形成におけるSINE配列のDNAメチル化ダイナミクスと機能制御

    Grant number:22770009  2010.4 - 2012.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  9. マウスにおけるエピゲノム種内多型の同定および遺伝的多型や表現型多様性との関係性

    Grant number:21200037  2009.4 - 2012.3

    科学研究費補助金  新学術領域研究

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    Authorship:Principal investigator 

  10. ゲノム中に大量に散在するレトロトラスポゾン配列のゲノム機能における役割

    Grant number:19770002  2007.3 - 2009.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 14

  1. 資源生物科学基盤実験実習

    2021

  2. 資源生物科学基盤実験実習

    2020

  3. 資源生物科学実験実習

    2020

  4. 生物情報処理演習

    2020

  5. 分子細胞生物学1

    2020

  6. 遺伝学

    2020

  7. 生物情報処理演習

    2018

  8. 動物遺伝学特論

    2018

  9. 分子細胞生物学1

    2018

  10. 遺伝学

    2018

  11. 生物学基礎II

    2018

  12. 分子生物学基礎II

    2017

  13. 動物遺伝・生理学特論

    2016

  14. 遺伝学

    2016

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Teaching Experience (Off-campus) 1

  1. エピジェネティクス特論

    2019.11 Kyushu University)

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    Level:Postgraduate 

 

Academic Activities 2

  1. 編集委員 International contribution

    Genes and Genetic Systems  2017.1

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    Type:Peer review 

  2. 編集委員

    Mobile DNA  2014.1

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    Type:Peer review