Updated on 2022/03/23

写真a

 
BUSTOS VILLALOBOS Itzel
 
Organization
Graduate School of Medicine Lecturer
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Lecturer
Contact information
メールアドレス
Profile
Experienced Associate Professor with a demonstrated history of working in the higher education industry. Skilled in Primary Cell Isolation, Cancer Immunotherapy, Cancer Research, Multi-color Flow Cytometry, and Bone Marrow Transplantation.
Strong education professional with a Doctor of Philosophy (PhD) focused in Pediatric Oncology from Nagoya University

Degree 2

  1. PhD ( 2010.3   名古屋大学 ) 

  2. MD degree ( 2002.1   Medical degree ) 

Research Areas 3

  1. Life Science / Tumor biology

  2. Life Science / Hematology and medical oncology

  3. Life Science / Immunology  / 膵癌

Current Research Project and SDGs 1

  1. PD-L1を標的としたウイルス表面リガンド改変腫瘍溶解性ウイルスの開発

 

Papers 19

  1. Relapse of leukemia with loss of mismatched HLA due to uniparental disomy following haploidentical hematopoietic stem cell transplantation Invited Reviewed

    Itzel Bustos Villalobos, Y. Takahashi, Y. Akatsuka, H. Muramatsu, N. Nishio, A.Hama, H. Yagasaki, H. Saji, M. Kato, S. Ogawa and S. Kojima

    Blood   Vol. 115 ( 15 ) page: 3158 - 3161   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

  2. S-1 facilitates canerpaturev (C-REV)-induced antitumor efficacy in a triple-negative breast cancer model

    Miyajima Noriyuki, Eissa Ibrahim Ragab, Abdelmoneim Mohamed, Naoe Yoshinori, Ichinose Toru, Matsumura Shigeru, Bustos-Villalobos Itzel, Mukoyama Nobuaki, Morimoto Daishi, Shibata Masahiro, Takeuchi Dai, Tsunoda Nobuyuki, Kikumori Toyone, Tanaka Maki, Kodera Yasuhiro, Kasuya Hideki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 4 ) page: 683 - 696   2021.11

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  3. Oncolytic herpes simplex virus HF10 (canerpaturev) promotes accumulation of CD8(+)PD-1(-) tumor-infiltrating T cells in PD-L1-enriched tumor microenvironment

    Eissa Ibrahim Ragab, Mukoyama Nobuaki, Abdelmoneim Mohamed, Naoe Yoshinori, Matsumura Shigeru, Bustos-Villalobos Itzel, Ichinose Toru, Miyajima Noriyuki, Morimoto Daishi, Tanaka Maki, Fujimoto Yasushi, Sone Michihiko, Kodera Yasuhiro, Kasuya Hideki

    INTERNATIONAL JOURNAL OF CANCER   Vol. 149 ( 1 ) page: 214 - 227   2021.7

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  4. C-REV Retains High Infectivity Regardless of the Expression Levels of cGAS and STING in Cultured Pancreatic Cancer Cells

    Morimoto Daishi, Matsumura Shigeru, Bustos-Villalobos Itzel, Sibal Patricia Angela, Ichinose Toru, Naoe Yoshinori, Eissa Ibrahim Ragab, Abdelmoneim Mohamed, Mukoyama Nobuaki, Miyajima Noriyuki, Tanaka Maki, Kodera Yasuhiro, Kasuya Hideki

    CELLS   Vol. 10 ( 6 )   2021.6

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  5. Problem-Based Learning in Child and Adolescent Psychiatry: A Perspective from Japan

    Iwatsuki Junko, Kondo Takeshi, Takahashi Noriyuki, Takami Hideki, Nishigori Hiroshi, Bustos-Villalobos Itzel, Aleksic Branko, Kasuya Hideki, Ban Nobutaro, Yagi Tetsuya, Skokauskas Norbert

    ADVANCES IN MEDICAL EDUCATION AND PRACTICE   Vol. 12   page: 1329 - 1335   2021

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  6. Combination of Cetuximab and Oncolytic Virus Canerpturev synergistically inhibits Human colorectal cancer Growth Invited Reviewed

    Wu Z, Ichinose T, Naoe Y, Matsumura S, Villalobos IB, Eissa IR, Miyajima N, Kasuya H

    Mol Ther Oncolytics     2019.5

  7. Joint degree program for graduate students at the Nagoya University Graduate school of medicine Invited Reviewed

    Kasuya H, Aleksic B, Sumigama S, Bustos I, Hasegawa H, Kasai MP, Kobayashi M, Samizo Y

    Nagoya J Med Sci     2019.5

  8. The Current Status and Future Prospects of Oncolytic Viruses in Clinical Trials against Melanoma, Glioma, Pancreatic, and Breast Cancers

    Eissa Ibrahim Ragab, Bustos-Villalobos Itzel, Ichinose Toru, Matsumura Shigeru, Naoe Yoshinori, Miyajima Noriyuki, Morimoto Daishi, Mukoyama Nobuaki, Wu Zhiwen, Tanaka Maki, Hasegawa Hitoki, Sumigama Seiji, Aleksic Branko, Kodera Yasuhiro, Kasuya Hideki

    CANCERS   Vol. 10 ( 10 )   2018.10

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  9. The current status and future prospect of oncolytic viruses in clinical trials against Melanoma, Glioma, Pancreatic, and Breast cancers Invited Reviewed International coauthorship

    Eissa IR, Bustos-Villalobos I, Ichinose T, Matsumura S, Naoe Y, Miyajima N, Morimoto D, Mukoyama N, Tanaka M, Hasegawa H, Sumigama A, Aleksic B, Kodera Y, Kasuya H

    Cancers   Vol. 10 ( 10 )   2018.9

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    Language:English  

  10. A Phase I clinical trial od EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer Invited Reviewed International coauthorship

    Hirooka Y, Kasuya H, Ishikawa T, Kawashima H, Ohno E, Villalobos IB, Naoe Y, Ichinose T, Koyama N, Tanaka M, Kodera Y, Goto H

    BMC Cancer   Vol. 18 ( 1 ) page: 596   2018.5

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    Language:English  

  11. ITK inhibition for the targeted treatment of CTCL.

    Bustos-Villalobos I, Bergstrom JW, Haigh NE, Luna JI, Mitra A, Marusina AI, Merleev AA, Wang EA, Sukhov A, Sultani H, Liu R, Bhardwaj G, Guo W, Kung HJ, Lam KS, Maverakis E

    Journal of dermatological science   Vol. 87 ( 1 ) page: 88 - 91   2017.7

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    Language:English  

    DOI: 10.1016/j.jdermsci.2017.04.001

    PubMed

  12. Pathophysiology of autoimmune bullous diseases: Nature versus nurture Invited Reviewed

    Forum Patel, Reason Wilken, Falin B Patel, Hawa Sultani, Itzel Bustos, Christopher Duong, John J Zone, Siba P Raychaudhuri, Emanual Maverakis

    Indian Journal of Dermatology   Vol. 62 ( 3 ) page: 262 - 267   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  13. Curative effect of HF10 on liver and peritoneal metastasis mediated by host immunity Invited Reviewed

    12) Hotta Y, Kasuya H, Bustos Villalobos Itzel, Naoe Y, Ichinose T, Tanaka M, Kodera Y

    Oncolytic Virotherapy   Vol. 6   page: 31 - 38   2017.3

  14. CD4+ virtual memory: Antigen-inexperienced T cells reside in the naïve, regulatory, and memory T cell compartments at similar frequencies, implications for autoimmunity Invited Reviewed

    Marusina AI, Ono Y, Merleev AA, Shimoda M, Ogawa H, Wang EA, Kondo K, Olney L, Luxardi G, Miyamura Y, Yilma TD, Villalobos IB, Bergstrom JW, Kronenberg DG, Soulika AM, Adamopoulos IE, Maverakis E

    Journal of Autoimmunity   Vol. 77   page: 76 - 88   2017.2

  15. Genomic Signature of the Natural Oncolytic Herpes Simplex Virus HF10 and Its Therapeutic Role in Preclinical and Clinical Trials.

    Eissa IR, Naoe Y, Bustos-Villalobos I, Ichinose T, Tanaka M, Zhiwen W, Mukoyama N, Morimoto T, Miyajima N, Hitoki H, Sumigama S, Aleksic B, Kodera Y, Kasuya H

    Frontiers in oncology   Vol. 7   page: 149   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fonc.2017.00149

    PubMed

  16. Serbian Language version of the Modified Checklist for Autism in Toddlers, revised, with Follow-up: Cross-Cultural Adaptation and Assessment of Reliability Invited Reviewed

    Carakovac Mia, Jovanovic Jelena, Kalanj Marko, Rudic Nenad, Aleksic-Hil Olivera, Aleksic Branko, Villalobos Bustos Itzel, Kasuya Hideki, Ozaki Norio, Lecic-Tosevski Dusica, Pejovic-Milovancevic Milica

    Scientific report   Vol. 6   page: 38222   2016.12

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    Language:English  

  17. Persistence of Autoreactive IgA-Secreting B cells Despite Multiple Immunosuppressive Medications Including Rituximab (Anti-CD20 therapy): A Mechanism For Treatment-Resistant IgA Immunobullous Diseases Invited Reviewed

    He Yong, Michiko Shimoda, Yoko Ono, Itzel Bustos Villalobos, Mitra A, Maverakis E

    JAMA dermatology   Vol. 151 ( 6 ) page: 646 - 650   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  18. Multimodal therapy of idiopathic gangrenosum Invited Reviewed

    Victoria Sharon, Barbara Burrall, Forum Patel, Yong He, Thomas Konia, Itzel Bustos Villalobos, Maverakis E

    Dermatology on line Journal   Vol. 20 ( 6 ) page: 6   2014

  19. Lack of CD4+CD25+Foxp3+ regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki disease Invited Reviewed

    Yu Hirabayashi, Yoshiyuki Takahashi, Yinyan Xu, Kazuyuki Akane, Itzel Bustos Villalobos, Yusuke Okuno, Shinji Hasegawa, Hideki Muramatsu, Asahito Hama, Taichi Kato, S. Kojima

    European Journal of Pediatrics   Vol. 172 ( 6 )   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

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Presentations 2

  1. The Role of Technology in Education Today and into the Future Invited

    Academic Consortium 21 on line international Forum   2020.12.8 

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    Event date: 2020.12

    Presentation type:Oral presentation (invited, special)  

    Country:Thailand  

  2. Program Mixer on Summer Camp Bologna 2020 International conference

    GAME/ TEI 

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    Event date: 2020.7

    Country:Italy  

Works 1

  1. Started on line joint clinical case discussions internationally International coauthorship

    Itzel Bustos

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. PD-L1 as target for the development of a new oncolytic virus

    Grant number:18K15274  2018.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Bustos Itzel

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    The purpose of this study was to develop a novel oncolytic virus that not only has a tropism for PD-L1-expressing cells but also has a function as an immune checkpoint inhibitor. We have succeeded in constructing the anti-PD-L1 antibody gene vector, but have not yet created the desired virus. The combination of HF10 and anti-PD-L1 antibody against the bilateral flank tumors of mouse squamous cell carcinoma SCC VII showed a strong antitumor effect on the bilateral tumors. It was suggested that the infiltration of immune cells into the tumor is involved in this enhancement of antitumor effect.

 

Teaching Experience (On-campus) 5

  1. On line joint clinical case discussion

    2020

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    First time of clinical case discussion between CUHK, KU, NU and LMU. Organized by NU

  2. Introduction to endocrinology

    2020

  3. Basic of neurology

    2020

  4. Pediatrics

    2020

  5. USMLE quiz review

    2020