Updated on 2026/04/13

写真a

 
BUSTOS VILLALOBOS Itzel
 
Organization
Graduate School of Medicine Lecturer
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Lecturer
Contact information
メールアドレス
Profile
Experienced Associate Professor with a demonstrated history of working in the higher education industry. Skilled in Primary Cell Isolation, Cancer Immunotherapy, Cancer Research, Multi-color Flow Cytometry, and Bone Marrow Transplantation.
Strong education professional with a Doctor of Philosophy (PhD) focused in Pediatric Oncology from Nagoya University

Degree 2

  1. PhD ( 2010.3   名古屋大学 ) 

  2. MD degree ( 2002.1   Medical degree ) 

Research Areas 3

  1. Life Science / Tumor biology

  2. Life Science / Hematology and oncology

  3. Life Science / Immunology  / 膵癌

Current Research Project and SDGs 1

  1. PD-L1を標的としたウイルス表面リガンド改変腫瘍溶解性ウイルスの開発

Committee Memberships 1

  1. AMEE: Association for Medical Education in Europe   Membershio  

    2020.3 - 2023.3   

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    Committee type:Academic society

 

Papers 27

  1. Relapse of leukemia with loss of mismatched HLA due to uniparental disomy following haploidentical hematopoietic stem cell transplantation Invited Reviewed

    Itzel Bustos Villalobos, Y. Takahashi, Y. Akatsuka, H. Muramatsu, N. Nishio, A.Hama, H. Yagasaki, H. Saji, M. Kato, S. Ogawa and S. Kojima

    Blood   Vol. 115 ( 15 ) page: 3158 - 3161   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

  2. Enhancing mesothelin CAR T cell therapy for pancreatic cancer with an oncolytic herpes virus boosting CAR target antigen expression

    Aboalela, MA; Abdelmoneim, M; Matsumura, S; Eissa, IR; Bustos-Villalobos, I; Sibal, PA; Orikono, Y; Takido, Y; Naoe, Y; Kasuya, H

    CANCER IMMUNOLOGY IMMUNOTHERAPY   Vol. 74 ( 7 ) page: 202   2025.5

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  3. Bridging Cultures in Medical Education by Developing English Problem-Based Learning Scenarios at Nagoya University, Japan

    Aleksic, B; Villalobos, IB; Yagi, T; Skokauskas, N

    INTERNATIONAL MEDICAL EDUCATION   Vol. 4 ( 2 )   2025.4

  4. The Nagoya University and the University of Adelaide Joint PhD Degree Program in Medicine-A Program of Opportunity

    Aleksic, B; Arthur, A; Kasai-Prince, M; Chretien, B; Bustos-Villalobos, I; Plewa, C; Kasuya, H; Page, AJ; Zannettino, AC; Kimura, H

    ADVANCES IN MEDICAL EDUCATION AND PRACTICE   Vol. 18   page: 1635 - 1640   2025

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  5. Online Problem-Based Learning in Child and Adolescent Psychiatry at Nagoya University, Japan

    Kwon, D; Kondo, T; Takahashi, N; Takami, H; Nishigori, H; Aleksic, B; Bustos-Villalobos, I; Yagi, T; Skokauskas, N

    INTERNATIONAL MEDICAL EDUCATION   Vol. 3 ( 4 ) page: 501 - 511   2024.12

  6. STING activator 2′3′-cGAMP enhanced HSV-1-based oncolytic viral therapy

    Sibal, PA; Matsumura, S; Ichinose, T; Bustos-Villalobos, I; Morimoto, D; Eissa, IR; Abdelmoneim, M; Aboalela, MAM; Mukoyama, N; Tanaka, M; Naoe, Y; Kasuya, H

    MOLECULAR ONCOLOGY   Vol. 18 ( 5 ) page: 1259 - 1277   2024.5

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  7. The Impact of Metformin on Tumor-Infiltrated Immune Cells: Preclinical and Clinical Studies

    Abdelmoneim, M; Aboalela, MA; Naoe, Y; Matsumura, S; Eissa, IR; Bustos-Villalobos, I; Sibal, PA; Takido, Y; Kodera, Y; Kasuya, H

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 24 ( 17 )   2023.9

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  8. Undergraduate Interprofessional Education in the European Higher Education Area: A Systematic Review

    Colonnello, V; Kinoshita, Y; Yoshida, N; Villalobos, IB

    INTERNATIONAL MEDICAL EDUCATION   Vol. 2 ( 2 ) page: 100 - 112   2023.6

  9. Metformin enhances the antitumor activity of oncolytic herpes simplex virus HF10 (canerpaturev) in a pancreatic cell cancer subcutaneous model

    Abdelmoneim, M; Eissa, IR; Aboalela, MA; Naoe, Y; Matsumura, S; Sibal, PA; Bustos-Villalobos, I; Tanaka, M; Kodera, Y; Kasuya, H

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 21570   2022.12

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  10. S-1 facilitates canerpaturev (C-REV)-induced antitumor efficacy in a triple-negative breast cancer model Open Access

    Miyajima, N; Eissa, IR; Abdelmoneim, M; Naoe, Y; Ichinose, T; Matsumura, S; Bustos-Villalobos, I; Mukoyama, N; Morimoto, D; Shibata, M; Takeuchi, D; Tsunoda, N; Kikumori, T; Tanaka, M; Kodera, Y; Kasuya, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 4 ) page: 683 - 696   2021.11

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  11. Oncolytic herpes simplex virus HF10 (canerpaturev) promotes accumulation of CD8<SUP>+</SUP>PD-1<SUP>-</SUP> tumor-infiltrating T cells in PD-L1-enriched tumor microenvironment Open Access

    Eissa, IR; Mukoyama, N; Abdelmoneim, M; Naoe, Y; Matsumura, S; Bustos-Villalobos, I; Ichinose, T; Miyajima, N; Morimoto, D; Tanaka, M; Fujimoto, Y; Sone, M; Kodera, Y; Kasuya, H

    INTERNATIONAL JOURNAL OF CANCER   Vol. 149 ( 1 ) page: 214 - 227   2021.7

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  12. C-REV Retains High Infectivity Regardless of the Expression Levels of cGAS and STING in Cultured Pancreatic Cancer Cells Open Access

    Morimoto, D; Matsumura, S; Bustos-Villalobos, I; Sibal, PA; Ichinose, T; Naoe, Y; Eissa, IR; Abdelmoneim, M; Mukoyama, N; Miyajima, N; Tanaka, M; Kodera, Y; Kasuya, H

    CELLS   Vol. 10 ( 6 )   2021.6

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  13. Problem-Based Learning in Child and Adolescent Psychiatry: A Perspective from Japan Open Access

    Iwatsuki, J; Kondo, T; Takahashi, N; Takami, H; Nishigori, H; Bustos-Villalobos, I; Aleksic, B; Kasuya, H; Ban, NO; Yagi, T; Skokauskas, N

    ADVANCES IN MEDICAL EDUCATION AND PRACTICE   Vol. 12   page: 1329 - 1335   2021

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  14. Combination of Cetuximab and Oncolytic Virus Canerpturev synergistically inhibits Human colorectal cancer Growth Invited Reviewed

    Wu Z, Ichinose T, Naoe Y, Matsumura S, Villalobos IB, Eissa IR, Miyajima N, Kasuya H

    Mol Ther Oncolytics     2019.5

  15. Joint degree program for graduate students at the Nagoya University Graduate school of medicine Invited Reviewed Open Access

    Kasuya H, Aleksic B, Sumigama S, Bustos I, Hasegawa H, Kasai MP, Kobayashi M, Samizo Y

    Nagoya J Med Sci     2019.5

  16. The Current Status and Future Prospects of Oncolytic Viruses in Clinical Trials against Melanoma, Glioma, Pancreatic, and Breast Cancers Open Access

    Eissa, IR; Bustos-Villalobos, I; Ichinose, T; Matsumura, S; Naoe, Y; Miyajima, N; Morimoto, D; Mukoyama, N; Wu, ZW; Tanaka, M; Hasegawa, H; Sumigama, S; Aleksic, B; Kodera, Y; Kasuya, H

    CANCERS   Vol. 10 ( 10 )   2018.10

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  17. The current status and future prospect of oncolytic viruses in clinical trials against Melanoma, Glioma, Pancreatic, and Breast cancers Invited Reviewed International coauthorship

    Eissa IR, Bustos-Villalobos I, Ichinose T, Matsumura S, Naoe Y, Miyajima N, Morimoto D, Mukoyama N, Tanaka M, Hasegawa H, Sumigama A, Aleksic B, Kodera Y, Kasuya H

    Cancers   Vol. 10 ( 10 )   2018.9

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    Language:English  

  18. A Phase I clinical trial od EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer Invited Reviewed International coauthorship

    Hirooka Y, Kasuya H, Ishikawa T, Kawashima H, Ohno E, Villalobos IB, Naoe Y, Ichinose T, Koyama N, Tanaka M, Kodera Y, Goto H

    BMC Cancer   Vol. 18 ( 1 ) page: 596   2018.5

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    Language:English  

  19. ITK inhibition for the targeted treatment of CTCL. Open Access

    Bustos-Villalobos I, Bergstrom JW, Haigh NE, Luna JI, Mitra A, Marusina AI, Merleev AA, Wang EA, Sukhov A, Sultani H, Liu R, Bhardwaj G, Guo W, Kung HJ, Lam KS, Maverakis E

    Journal of dermatological science   Vol. 87 ( 1 ) page: 88 - 91   2017.7

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    Language:English  

    DOI: 10.1016/j.jdermsci.2017.04.001

    PubMed

  20. Pathophysiology of autoimmune bullous diseases: Nature versus nurture Invited Reviewed

    Forum Patel, Reason Wilken, Falin B Patel, Hawa Sultani, Itzel Bustos, Christopher Duong, John J Zone, Siba P Raychaudhuri, Emanual Maverakis

    Indian Journal of Dermatology   Vol. 62 ( 3 ) page: 262 - 267   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4103/0019-5154.159620

  21. Curative effect of HF10 on liver and peritoneal metastasis mediated by host immunity Invited Reviewed

    12) Hotta Y, Kasuya H, Bustos Villalobos Itzel, Naoe Y, Ichinose T, Tanaka M, Kodera Y

    Oncolytic Virotherapy   Vol. 6   page: 31 - 38   2017.3

  22. CD4+ virtual memory: Antigen-inexperienced T cells reside in the naïve, regulatory, and memory T cell compartments at similar frequencies, implications for autoimmunity Invited Reviewed

    Marusina AI, Ono Y, Merleev AA, Shimoda M, Ogawa H, Wang EA, Kondo K, Olney L, Luxardi G, Miyamura Y, Yilma TD, Villalobos IB, Bergstrom JW, Kronenberg DG, Soulika AM, Adamopoulos IE, Maverakis E

    Journal of Autoimmunity   Vol. 77   page: 76 - 88   2017.2

  23. Genomic Signature of the Natural Oncolytic Herpes Simplex Virus HF10 and Its Therapeutic Role in Preclinical and Clinical Trials. Open Access

    Eissa IR, Naoe Y, Bustos-Villalobos I, Ichinose T, Tanaka M, Zhiwen W, Mukoyama N, Morimoto T, Miyajima N, Hitoki H, Sumigama S, Aleksic B, Kodera Y, Kasuya H

    Frontiers in oncology   Vol. 7   page: 149   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fonc.2017.00149

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    PubMed

  24. Serbian Language version of the Modified Checklist for Autism in Toddlers, revised, with Follow-up: Cross-Cultural Adaptation and Assessment of Reliability Invited Reviewed

    Carakovac Mia, Jovanovic Jelena, Kalanj Marko, Rudic Nenad, Aleksic-Hil Olivera, Aleksic Branko, Villalobos Bustos Itzel, Kasuya Hideki, Ozaki Norio, Lecic-Tosevski Dusica, Pejovic-Milovancevic Milica

    Scientific report   Vol. 6   page: 38222   2016.12

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    Language:English  

    DOI: 10.1038/srep38222

  25. Persistence of Autoreactive IgA-Secreting B cells Despite Multiple Immunosuppressive Medications Including Rituximab (Anti-CD20 therapy): A Mechanism For Treatment-Resistant IgA Immunobullous Diseases Invited Reviewed

    He Yong, Michiko Shimoda, Yoko Ono, Itzel Bustos Villalobos, Mitra A, Maverakis E

    JAMA dermatology   Vol. 151 ( 6 ) page: 646 - 650   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  26. Multimodal therapy of idiopathic gangrenosum Invited Reviewed

    Victoria Sharon, Barbara Burrall, Forum Patel, Yong He, Thomas Konia, Itzel Bustos Villalobos, Maverakis E

    Dermatology on line Journal   Vol. 20 ( 6 ) page: 6   2014

  27. Lack of CD4+CD25+Foxp3+ regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki disease Invited Reviewed

    Yu Hirabayashi, Yoshiyuki Takahashi, Yinyan Xu, Kazuyuki Akane, Itzel Bustos Villalobos, Yusuke Okuno, Shinji Hasegawa, Hideki Muramatsu, Asahito Hama, Taichi Kato, S. Kojima

    European Journal of Pediatrics   Vol. 172 ( 6 )   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00431-013-1937-3

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Presentations 2

  1. The Role of Technology in Education Today and into the Future Invited

    Academic Consortium 21 on line international Forum   2020.12.8 

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    Event date: 2020.12

    Presentation type:Oral presentation (invited, special)  

    Country:Thailand  

  2. Program Mixer on Summer Camp Bologna 2020 International conference

    GAME/ TEI 

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    Event date: 2020.7

    Country:Italy  

Works 1

  1. Started on line joint clinical case discussions internationally International coauthorship

    Itzel Bustos

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. PD-L1 as target for the development of a new oncolytic virus

    Grant number:18K15274  2018.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Bustos Itzel

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    The purpose of this study was to develop a novel oncolytic virus that not only has a tropism for PD-L1-expressing cells but also has a function as an immune checkpoint inhibitor. We have succeeded in constructing the anti-PD-L1 antibody gene vector, but have not yet created the desired virus. The combination of HF10 and anti-PD-L1 antibody against the bilateral flank tumors of mouse squamous cell carcinoma SCC VII showed a strong antitumor effect on the bilateral tumors. It was suggested that the infiltration of immune cells into the tumor is involved in this enhancement of antitumor effect.

 

Teaching Experience (On-campus) 13

  1. Pediatrics

    2022

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    Lectures of paediatrics delivered in English for medical students of 4th and 5th year

  2. Introduction to Neuroanatomy

    2022

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    Introductory classes to medicine in English. We revise basic neuroanatomy for first grade medical students.

  3. Medical English II

    2022

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    Teaching students Medical terms as well as importance of Globalization in Medicine

  4. Medical English I

    2026

  5. Medical English I

    2025

  6. Joint on line clinical case discussion

    2024

  7. Medical English I

    2024

  8. Joint on line clinical case discussion

    2023

  9. On line joint clinical case discussion

    2020

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    First time of clinical case discussion between CUHK, KU, NU and LMU. Organized by NU

  10. Introduction to endocrinology

    2020

  11. Basic of neurology

    2020

  12. Pediatrics

    2020

  13. USMLE quiz review

    2020

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