Faculty Profiles - NIIMI Kiyoaki

リンパ浮腫 Reviewed

新美清章（ Role： Joint author）

医学書院 2020

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Responsible for pages：928-930 Language：Japanese Book type：Textbook, survey, introduction

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Presentations 3

悪性腫瘍患者での深部静脈血栓症診断のための最適なＤダイマーカットオフ値の検証

新美清章1, 西田一貴2, 李昌史1, 池田脩太1, 川井陽平1, 杉本昌之1, 坂野比呂志1

第43回日本静脈学会 2023.7.7

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Event date： 2023.7

Language：Japanese Presentation type：Oral presentation (general)
下腿難治性皮膚潰瘍における人工炭酸泉足浴療法と高気圧酸素療法併用の治療効果

新美清章1，2，佐藤誠洋1, 池田脩太1，鶴岡琢也1，川井陽平1，杉本昌之1，児玉章朗1，坂野比呂志1，古森公浩

第50回　日本血管外科学会 2022.5.16

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Event date： 2022.5

Language：Japanese Presentation type：Oral presentation (general)
VTE診療におけるDVTスクリーニングとDダイマー測定の意義について

新美　清章

日本静脈学会 2020.6.18

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Event date： 2020.6

Language：Japanese Presentation type：Oral presentation (general)

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KAKENHI (Grants-in-Aid for Scientific Research) 4

Analysis of a blood flow modification model for aortic aneurysm suppression.

Grant number：21K08841
大動脈瘤抑制のための血流改変モデルの解析

Grant number：21K08841 2021.4 - 2024.3

科学研究費助成事業基盤研究(C)

新美清章, 古森公浩, 坂野比呂志, 児玉章朗

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Authorship：Principal investigator

Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

腹部大動脈瘤は下肢の動脈瘤も含め、動脈の分岐点で乱流の生じやすい部位に好発し、腹部大動脈瘤は多くは大動脈分岐上、総腸骨動脈瘤や総大腿動脈瘤も同様に分岐直上にできる。一方、直線状になっている外腸骨動脈や浅大腿動脈の瘤化はほとんどない。本研究の目的は、大動脈瘤抑制のための血流改変モデルを作製解析することで腹部大動脈瘤形成および進展のメカニズムを明らかにし、その上で新たな血管病の治療戦略を呈示することにある。
Potent Inhibiting Effect of Activated vitamine D3 on Aortic Aneurysm Dilatation

Grant number：17K10753 2017.4 - 2020.3

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

NIIMI Kiyoaki

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Authorship：Principal investigator

Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

The activity of endogenous MCP-1 was significantly lower in the calsitriol group than in the Saline group. However, there was no significant difference in expression level of IL-1βand MMP-9 causing degeneration of the extracellular matrix between the Saline and calsitriol groups. In that series, we decided to evaluate another anti-inflammatory subject that can suppress atherosclerotic disease. Montelukast is a selective CVS-LT-1receptor antagonist that could surpress atherosclerotic diseases. We evaluated the in vitro properties of montelukast and its in vivo activities in an angiotensinⅡ-infused apolipoprotein E-deficient AAA mouse model. Relative to control,montelukast significantly suppressed gene expression of MMP-2, MMP-9, and IL-1β.In vivo,montelukast significantly decreased aortic expansion and induced infiltration of M2 macrophages.
Impact of Clopidogrel and Prasugrel on suppression of autogenous vein graft.

Grant number：15K10240 2015.4 - 2018.3

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

KODAMA Akio

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Authorship：Coinvestigator(s)

We performed reversed vein graft under normal and poor run-off model.　At first some of grafted veins were occluded because of technical problems, thereby, it was difficult to evaluate the effects of Clopidogrel and Prasugrel. Finally the technical problems were resolved. At the same time we tried to search the optimal administration methods and dosage of these drugs. However, we could not to find them. Therefore, we made some grafted veins of Edoxaban-treated rabbits. The assessment of intimal hyperplasia did not show significant differences in their lumen area, intimal thickness, medial thickness, and intima/media index between control grafted veins and Edoxaban-treated grafted veins.

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