Faculty Profiles - TAKEICHI Takuya

Takuya Hanamura, Michihiro Kono, Kenji Yokota, Takuya Takeichi, Kei Kohno, Shigeo Nakamura, Teruyuki Mitsuma, Kosei Nakajima, Yoshinao Muro, Masashi Akiyama

The Journal of dermatology Vol. 46 ( 3 ) page： E97 - E99 2019.3

The lipoxygenase-hepoxilin pathway is activated in cutaneous plaque lesions of psoriasis Reviewed International journal

Takuya Takeichi, Fumie Kinoshita, Hirotaka Tanaka, Setsuko Fujita, Yumiko Kobayashi, Masahiro Nakatochi, Kazumitsu Sugiura, Masashi Akiyama

Journal of Cutaneous Immunology and Allergy Vol. 2 ( 1 ) page： 15 - 24 2019.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Blackwell Publishing Ltd

Psoriasis is a common skin disorder that is characterized by hyperkeratosis, epidermal hyperplasia, T-cell and neutrophil recruitment, and changes in the vascular endothelial system. The several upregulated variable lipid mediators, including the eicosanoids, in psoriatic keratinocytes were described previously, although some results were contradictory. Since hepoxilin is less stable than other eicosanoids such as hydroxyeicosatetraenoic acid (HETE), the measurement of hepoxilin is difficult. In this study, to clarify the relationship between hepoxilin/hepoxilin-related fatty acid derivatives and psoriasis vulgaris, we evaluated the amount of production of lipid mediators including hepoxilins in skin tissues of patients with psoriasis vulgaris in comparison with normal controls by high-performance liquid chromatography/mass spectrometry. Most of the hepoxilins and related lipids evaluated in this study tended to be more abundant in the lesional skin from the psoriasis patient group (PPG) than in the skin from controls. Interestingly, 12R-HETE was markedly higher in the skin samples from the PPG. In addition, the lipids produced in the lipoxygenase pathway, including hepoxilin, were elevated in the skin lesions of the PPG compared with those of normal controls, whereas the lipids produced in the cyclooxygenase pathway were decreased in the skin lesions from the PPG. Our results suggest that an imbalance between the lipoxygenase and cyclooxygenase pathways may contribute to psoriatic pathomechanisms.

DOI： 10.1002/cia2.12039

Web of Science

Scopus

A novel missense mutation in the ABCA12 gene in Japanese siblings with congenital ichthyosis erythroderma Reviewed

Kobashi H., Ishimoto T., Yamamoto M., Nakajima K., Takeichi T., Akiyama S., Sano S.

Nishinihon Journal of Dermatology Vol. 81 ( 5 ) page： 382 - 386 2019

[Successful treatment of pre-engraftment disseminated fusariosis with high-dose liposomal amphotericin B in a cord blood transplant recipient]. Reviewed

Yasuhiko Harada, Makoto Murata, Akane Matsumoto, Daizo Kato, Tetsuya Yagi, Takashi Yaguchi, Takenori Yoshikawa, Takuya Takeichi, Masashi Akiyama, Yohei Yamaguchi, Daisuke Koyama, Seitaro Terakura, Tetsuya Nishida, Hitoshi Kiyoi

[Rinsho ketsueki] The Japanese journal of clinical hematology Vol. 60 ( 12 ) page： 1641 - 1646 2019

Language：Japanese Publishing type：Research paper (scientific journal)

A 47-year-old man with acute myeloid leukemia and myelodysplastic-related changes relapsed after an allogenic bone marrow transplant and received a cord blood transplant as salvage therapy. The patient developed febrile neutropenia that was resistant to broad-spectrum antibiotics and multiple, painful, nodular skin lesions on his trunk and extremities before engraftment. A skin biopsy and blood culture found mold, and the subsequent microscopic examination, mass spectrometry, and DNA sequencing of the fungal colonies identified Fusarium solani. The patient's fever and skin lesions began to improve with the administration of liposomal amphotericin B at 5 mg/kg/day. Neutrophilic engraftment occurred on day 19. Stage 3 acute skin graft-versus-host disease was cured by the application of topical steroid. Unexpectedly, a change from liposomal amphotericin B to voriconazole on day 38 exacerbated the Fusarium infection. The Fusarium infection was finally cured by the administration of liposomal amphotericin B for a total of 19 weeks. Neutrophilic engraftment, an immediate definitive diagnosis, the sufficient and long-term administration of appropriate antifungal medication, and avoidance of the systemic administration of steroids might have contributed to the successful outcome of this patient.

DOI： 10.11406/rinketsu.60.1641

PubMed

Reduction of stratum corneum ceramides in Neu-Laxova syndrome caused by phosphoglycerate dehydrogenase deficiency. Reviewed International journal

Takuya Takeichi, Yusuke Okuno, Akane Kawamoto, Takeshi Inoue, Eiko Nagamoto, Chiaki Murase, Eri Shimizu, Kenichi Tanaka, Yuichi Kageshita, Satoshi Fukushima, Michihiro Kono, Junko Ishikawa, Hironobu Ihn, Yoshiyuki Takahashi, Masashi Akiyama

Journal of lipid research Vol. 59 ( 12 ) page： 2413 - 2420 2018.12

Language：English Publishing type：Research paper (scientific journal)

Neu-Laxova syndrome (NLS) is a very rare autosomal recessive congenital disorder characterized by disturbed development of the central nervous system and the skin and caused by mutations in any of the three genes involved in de novo l-serine biosynthesis: PHGDH, PSAT1, and PSPH l-Serine is essential for the biosynthesis of phosphatidylserine and sphingolipids. The extracellular lipid of the stratum corneum, of which sphingolipid constitutes a significant part, plays a primary role in skin barrier function. Here, we describe a Japanese NLS pedigree with a previously unreported nonsense mutation in PHGDH and a unique inversion of chromosome 1. In addition, the levels of 11 major ceramide classes in the tape-stripped stratum corneum of the NLS patient's skin were assessed by LC/MS. Notably, lower amounts of ceramides of all classes were found in the patient's stratum corneum than in those of controls. This is the first report to demonstrate the reduction of ceramides in the stratum corneum of an NLS patient due to PHGDH mutations. The clinical findings and a detailed analysis of ceramides from the stratum corneum in the family extend the spectrum of clinical anomalies and give us a clue to the pathomechanisms of ichthyosis in NLS patients with phosphoglycerate dehydrogenase deficiency.

DOI： 10.1194/jlr.P087536

Web of Science

Scopus

PubMed

Hearing impairment: A secondary symptom in a congenital ichthyosiform erythroderma patient with ABCA12 mutations. Reviewed International journal

Chiaki Murase, Takuya Takeichi, Kazumitsu Sugiura, Miki Kobayashi, Kozue Shiomi, Kaichiro Ikebuchi, Yutaka Tsutsumi, Masashi Akiyama

The Journal of dermatology Vol. 45 ( 11 ) page： E303 - E304 2018.11

Dyschromatosis symmetrica hereditaria may be successfully controlled by topical sunscreen. Reviewed International journal

Michihiro Kono, Takashi Okamoto, Takuya Takeichi, Yoshinao Muro, Masashi Akiyama

European journal of dermatology : EJD Vol. 28 ( 6 ) page： 840 - 841 2018.11

Cross-sectional survey on disease severity in Japanese patients with harlequin ichthyosis/ichthyosis: Syndromic forms and quality-of-life analysis in a subgroup. Reviewed International journal

Chiaki Murase, Takuya Takeichi, Akitaka Shibata, Masahiro Nakatochi, Fumie Kinoshita, Akiharu Kubo, Kimiko Nakajima, Norito Ishii, Hiroo Amano, Koji Masuda, Hiroshi Kawakami, Takuro Kanekura, Ken Washio, Masayuki Asano, Kazuya Teramura, Eijiro Akasaka, Mikiko Tohyama, Yutaka Hatano, Toyoko Ochiai, Shinichi Moriwaki, Tomotaka Sato, Akemi Ishida-Yamamoto, Mariko Seishima, Michiko Kurosawa, Shigaku Ikeda, Masashi Akiyama

Journal of dermatological science Vol. 92 ( 2 ) page： 127 - 133 2018.11

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Congenital ichthyoses (CIs) adversely affect quality of life (QOL) in patients. However, the effects of CIs on patient QOL have not been studied sufficiently. OBJECTIVE: To investigate the association between disease severity and QOL in patients with harlequin ichthyosis (HI) and ichthyosis: syndromic forms (ISFs) METHODS: Clinical information of patients with HI and ISFs from 2010 to 2015 were obtained from 100 dermatology departments/divisions of principal institutes/hospitals throughout Japan. We examined the relationship between disease severity and QOL in patients with HI and ISFs. Patients who were aged 8 years or older and participated in a multicenter retrospective questionnaire survey in Japan were assessed by dermatology life quality index (DLQI, range of 0-30) and clinical ichthyosis score (range of 0-100). RESULTS: Netherton syndrome patients had a significantly higher risk of allergy to food or environmental allergens than patients with other phenotypes. Keratitis-ichthyosis-deafness (KID) syndrome patients showed a significantly higher risk of skin infections than patients with other phenotypes. Complete data on DLQI were obtained from 13 patients, whose median age was 21 (8-71) years. Nine patients were male, and 4 were female. Systemic retinoids were administrated to 2 of the 3 HI patients. The Spearman's correlation coefficient between the clinical ichthyosis score and DLQI was 0.611 (P < 0.05). CONCLUSION: We confirmed that Netherton syndrome and KID syndrome patients have a higher risk of allergy to food or environmental allergens and of skin infections, respectively. QOL impairment correlates with disease severity in HI and ISFs patients.

DOI： 10.1016/j.jdermsci.2018.08.008

Web of Science

Scopus

PubMed

Autosomal dominant progressive hyperpigmentation and lentigines in a Japanese pedigree due to a missense mutation near the C-terminus of KIT. Reviewed International journal

T Takeichi, K Sugiura, K Tanahashi, K Noda, M Kono, M Akiyama

The British journal of dermatology Vol. 179 ( 5 ) page： 1210 - 1211 2018.11

Mild Hailey-Hailey disease cases with aberrant splicing variants of ATP2C1 successfully controlled with excimer light. Reviewed

Kono M, Niizawa M, Takeichi T, Muro Y, Akiyama M

Journal of the European Academy of Dermatology and Venereology : JEADV Vol. 32 ( 11 ) page： E413 - E416 2018.11

Sterol profiles are valuable biomarkers for phenotype expression of Conradi-Hünermann-Happle syndrome with EBP mutations. Reviewed

Takeichi T, Honda A, Okuno Y, Kojima D, Kono M, Nakamura Y, Tohyama M, Tanaka T, Aoyama Y, Akiyama M

The British journal of dermatology Vol. 179 ( 5 ) page： 1186 - 1188 2018.11

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Papers - TAKEICHI Takuya