Faculty Profiles - TAKEICHI Takuya

Papers - TAKEICHI Takuya

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Comparing the severity of epidermolysis bullosa simplex harboring KRT5 variants with the AlphaMissense score. Reviewed International journal

Michiya Omi, Takuya Takeichi, Takenori Yoshikawa, Yuki Inoue, Ryo Fukaura, Ikumi Hattori, Yuka Nakazawa, Tatsuhiro Noda, Yoshinao Muro, Masashi Akiyama

The Journal of dermatology 2024.10

Generalized pustular psoriasis patient with a heterozygous hypomorphic MPO variant refractory to intravenous spesolimab. Reviewed International journal

Youichi Ogawa, Eri Maejima, Takuya Takeichi, Takashi Okamoto, Hiroshi Mitsui, Shinji Shimada, Masashi Akiyama, Tatsuyoshi Kawamura

The Journal of dermatology Vol. 52 ( 1 ) page： 167 - 170 2024.9

Language：English Publishing type：Research paper (scientific journal)

Generalized pustular psoriasis (GPP) is a recurrent and sometimes life-threatening sterile pustular disease. Because interleukin (IL)-36 is the central cytokine in disease formation, spesolimab, which interferes with IL-36 receptor signaling, is highly effective. Here, we report a patient with GPP with a heterozygous hypomorphic MPO variant refractory to intravenous spesolimab. Although spesolimab showed excellent clinical efficacy in resolving pre-existing pustules and erythema, it did not suppress the emergence of new pustules and erythema, which did not decrease the peripheral blood neutrophil count, therefore bimekizumab, an anti-IL-17A/IL-17F antibody, was administered after the second spesolimab infusion, which resolved the pustules and erythema. We discuss the possible reasons for the resistance mechanism to spesolimab.

DOI： 10.1111/1346-8138.17464

Web of Science

Scopus

PubMed

Correlation of serum allergen-specific IgE with total serum IgE and IgE specific to other allergens in Atopic dermatitis patients. Reviewed International journal

Norika Akashi, Mariko Ogawa-Momohara, Tomoki Taki, Ryo Fukaura, Keiko Wakahara, Satoshi Kamiya, Yuta Yamashita, Haruka Koizumi, Takuya Takeichi, Yoshinao Muro, Masashi Akiyama

Journal of the European Academy of Dermatology and Venereology : JEADV Vol. 38 ( 9 ) page： e761 - e763 2024.9

Multiple subcutaneous reactive angioendotheliomatosis in a patient with antiphospholipid syndrome. Reviewed International journal

Takashi Yokoyama, Masato Nakaguro, Mariko Ogawa-Momohara, Yoshihisa Nakano, Ryo Fukaura, Takuya Takeichi, Yoshinao Muro, Masashi Akiyama

Clinical and experimental dermatology Vol. 49 ( 11 ) page： 1452 - 1455 2024.8

Comment on: Longitudinal study of patients with anti-SAE antibody-positive dermatomyositis: a multicenter cohort study in China. Reviewed International journal

Yuta Yamashita, Yoshinao Muro, Haruka Koizumi, Satoshi Kamiya, Norika Akashi, Mariko Ogawa-Momohara, Takuya Takeichi, Masashi Akiyama

Rheumatology (Oxford, England) 2024.8

A novel splicing CYLD variant associated with trichoepithelioma papulosum multiplex demonstrating intrafamilial severity variability. Reviewed International journal

Ryo Fukaura, Takuya Takeichi, Tatsuhiro Noda, Mariko Seishima, Yoshinao Muro, Masashi Akiyama

The Journal of dermatology Vol. 51 ( 8 ) page： e274 - e276 2024.8

Localized epidermolysis bullosa simplex caused by a previously unreported substitution in the linker 12 domain of keratin 14. Reviewed International journal

Miyu Misaki, Takuya Takeichi, Michiya Omi, Yasutoshi Ito, Tomoo Ogi, Yoshinao Muro, Masashi Akiyama

The Journal of dermatology Vol. 51 ( 8 ) page： e264 - e265 2024.8

Cross-sectional nationwide epidemiologic survey on quality of life and treatment efficacy in Japanese patients with congenital ichthyoses Reviewed International journal

Suzuki, Y; Tanahashi, K; Terashima-Murase, C; Takeichi, T; Kobayashi, Y; Kinoshita, F; Akiyama, M

JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 144 ( 8 ) page： S37 - S37 2024.8

A case of pachyonychia congenita with a hotspot variant at Arg127 in KRT16: Disease severity assessment using AlphaMissense technology. Reviewed International journal

Tatsuhiro Noda, Takuya Takeichi, Kana Tanahashi, Yoshinao Muro, Masashi Akiyama

The Journal of dermatology Vol. 51 ( 8 ) page： 1134 - 1136 2024.8

A Netherton syndrome infant complicated with infective endocarditis. Reviewed International journal

Mahori Tago, Takuya Takeichi, Yuika Suzuki, Takenori Yoshikawa, Yoshiaki Sato, Taichi Kato, Kiyotaka Go, Takashi Sakaida, Yoshinao Muro, Masashi Akiyama

The Journal of dermatology Vol. 52 ( 1 ) page： e12 - e13 2024.7

Panniculitis on the trunk as a possible characteristic feature of anti-SAE1/2 antibody-positive dermatomyositis: A possible cutaneous manifestation of treatment resistance. Reviewed International journal

Mahori Tago, Haruka Koizumi, Satoshi Kamiya, Norika Akashi, Akira Miyazaki, Yuta Yamashita, Mariko Ogawa-Momohara, Takuya Takeichi, Yoshinao Muro, Masashi Akiyama

The Journal of dermatology Vol. 51 ( 7 ) page： e227 - e228 2024.7

病変部毛包内に毛包虫を認めたMorbihan病の1例 Reviewed

竹内想, 武市拓也, 中黒匡人, 秋山真志

皮膚科の臨床 2024.7

角化症の研究から学ぶこと

武市拓也

角化症研究会記録集 2024.7

悪性黒色腫が多発したKRT10変異によるichthyosis with confettiの1例

勅使河原眞子, 武市拓也, 棚橋華奈, 室慶直, 秋山真志, 伊藤靖敏, 中川浩一, 萩朋男

角化症研究会記録集 2024.7

Treating epidermolytic ichthyosis and ichthyosis with confetti with epidermal autografts cultured from revertant skin. Reviewed International journal

Kana Tanahashi, Michihiro Kono, Takenori Yoshikawa, Yuika Suzuki, Masukazu Inoie, Yachiyo Kuwatsuka, Fumie Kinoshita, Takuya Takeichi, Masashi Akiyama

The British journal of dermatology Vol. 191 ( 3 ) page： 397 - 404 2024.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: No efficient treatment has been established yet for epidermolytic ichthyosis (EI) caused by pathogenic variants in KRT1 or KRT10. Patients with ichthyosis with confetti (IWC) show multiple normal-appearing spots, caused by the revertant somatic recombination of pathogenic variants that occurs at each spot independently. Additionally, some patients with EI have large areas of normal skin due to revertant postzygotic mosaicism. OBJECTIVE: To assess the feasibility transplanting cultured epidermal autografts (CEAs) produced from revertant epidermal keratinocytes in patients with EI and IWC. METHODS: We performed a clinical trial of treatment with CEAs produced from each patient's own revertant epidermal keratinocytes as a proof-of-concept study. This is a single-arm, open (masking not used), uncontrolled, single-assignment, treatment purpose study. The primary outcome was the rate of areas without the recurrence of ichthyosis lesions 4 weeks after the final transplant (%). The secondary outcome was the rate of areas without the recurrence of ichthyosis lesions 24 weeks after initial transplantation (%). RESULTS: We successfully produced CEAs from the genetically confirmed revertant skin of the two mosaic EI patients and one IWC patient and genetically confirmed that CEAs mainly consist of revertant wild-type cells by amplicon sequencing and droplet digital PCR analysis. Single-cell RNA sequencing analysis confirmed the normal proliferation and safety profiling of CEAs. CEAs were transplanted to desquamated lesional sites of the patients. Four weeks after this transplantation, the rate of areas without the recurrence of ichthyosis lesions in the three cases was 39.52%, 100.0%, and 100.0% respectively, although the recurrence of ichthyosis lesions was seen at the site of CEA transplantation in all three patients at 24 weeks after transplantation. CONCLUSION: CEAs from normal skin have the potential to be a safe and local treatment option for EI and IWC. TRIAL REGISTRATION: jRCTb041190097.

DOI： 10.1093/bjd/ljae193

Web of Science

Scopus

PubMed

Two patients with Hailey-Hailey disease with novel pathogenic ATP2C1 variants suggesting possible genotype/phenotype correlations. Reviewed International journal

Michiya Omi, Takuya Takeichi, Yasutoshi Ito, Takenori Yoshikawa, Yuki Mizutani, Miki Nagai, Mariko Seishima, Tomoo Ogi, Yoshinao Muro, Masashi Akiyama

The Journal of dermatology Vol. 51 ( 6 ) page： e185 - e187 2024.6

Combined oral lichen planus and oral lichenoid contact hypersensitivity reaction in a patient with Hashimoto's thyroiditis

Suzuki S., Yamashita Y., Fujio M., Hanai Y., Koizumi H., Ogawa-Momohara M., Takeichi T., Muro Y., Akiyama M.

Oral Oncology Reports Vol. 10 2024.6

ELISA detection of anti-eIF2B antibodies in Japanese patients with systemic sclerosis. Reviewed International journal

Haruka Koizumi, Yasuhiko Yamano, Yoshinao Muro, Ryo Fukaura, Yuta Yamashita, Satoshi Kamiya, Norika Akashi, Mariko Ogawa-Momohara, Takuya Takeichi, Yasuhiro Kondoh, Masashi Akiyama

Rheumatology (Oxford, England) Vol. 63 ( 6 ) page： e164 - e165 2024.5

Natal teeth, hypoplasia of the first toe, and growth retardation in a patient with severe epidermolysis bullosa simplex. Reviewed International journal

Maiko Shimomura-Ishihara, Takuya Takeichi, Tatsuhiro Noda, Haruka Koizumi, Teruyuki Mitsuma, Tomoo Ogi, Yoshinao Muro, Masashi Akiyama

The Journal of dermatology Vol. 51 ( 5 ) page： e175 - e177 2024.5

Exploring patient background and biomarkers associated with the development of dupilumab-associated conjunctivitis and blepharitis. Reviewed International journal

Makiko Kido-Nakahara, Daisuke Onozuka, Kenji Izuhara, Hidehisa Saeki, Satoshi Nunomura, Motoi Takenaka, Mai Matsumoto, Yoko Kataoka, Rai Fujimoto, Sakae Kaneko, Eishin Morita, Akio Tanaka, Ryo Saito, Tatsuro Okano, Tomomitsu Miyagaki, Natsuko Aoki, Kimiko Nakajima, Susumu Ichiyama, Kyoko Tonomura, Yukinobu Nakagawa, Risa Tamagawa-Mineoka, Koji Masuda, Takuya Takeichi, Masashi Akiyama, Yozo Ishiuji, Michie Katsuta, Yuki Kinoshita, Chiharu Tateishi, Aya Yamamoto, Akimichi Morita, Haruna Matsuda-Hirose, Yutaka Hatano, Hiroshi Kawasaki, Ayano Fukushima-Nomura, Mamitaro Ohtsuki, Koji Kamiya, Yudai Kabata, Riichiro Abe, Hiroshi Mitsui, Tatsuyoshi Kawamura, Gaku Tsuji, Masutaka Furue, Norito Katoh, Takeshi Nakahara

Allergology international : official journal of the Japanese Society of Allergology Vol. 73 ( 2 ) page： 332 - 334 2024.4

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Papers - TAKEICHI Takuya