Updated on 2024/09/18

写真a

 
OSUKA Satoko
 
Organization
Graduate School of Medicine Program in Integrated Medicine Medicine in Growth and Aging Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor

Degree 1

  1. Ph.D ( 2017.5   Nagoya University ) 

Research Areas 1

  1. Life Science / Obstetrics and gynecology  / Obstetrics and Gynecology

 

Papers 61

  1. Serum miRNA as a predictive biomarker for ovarian reserve after endometrioma-cystectomy

    Yabuki, A; Muraoka, A; Osuka, S; Yokoi, A; Yoshida, K; Kitagawa, M; Bayasura; Sonehara, R; Miyake, N; Nakanishi, N; Nakamura, T; Iwase, A; Kajiyama, H

    REPRODUCTIVE BIOLOGY   Vol. 24 ( 1 ) page: 100821   2024.3

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  2. Small extracellular vesicles in follicular fluids for predicting reproductive outcomes in assisted reproductive technology.

    Muraoka A, Yokoi A, Yoshida K, Kitagawa M, Asano-Inami E, Murakami M, Bayasula, Miyake N, Nakanishi N, Nakamura T, Osuka S, Iwase A, Kajiyama H

    Communications medicine   Vol. 4 ( 1 ) page: 33   2024.2

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    Language:English  

    DOI: 10.1038/s43856-024-00460-8

    PubMed

  3. The influence of radical trachelectomy on endometrial thickness in in vitro fertilization-embryo transfer

    Yabuki, A; Muraoka, A; Tamauchi, S; Seki, T; Takeda, T; Sonehara, R; Miyake, N; Nakamura, T; Osuka, S; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 2 ) page: 218 - 224   2024.2

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  4. Effect of radical trachelectomy on ovarian reserve: A single-institute prospective study

    Nakagawa, A; Tamauchi, S; Sato, M; Yoshihara, M; Yokoi, A; Shimizu, Y; Ikeda, Y; Yoshikawa, N; Niimi, K; Osuka, S; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 2 ) page: 212 - 217   2024.2

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  5. Anti-Müllerian hormone for screening, diagnosis, evaluation, and prediction: A systematic review and expert opinions

    Iwase, A; Asada, Y; Sugishita, Y; Osuka, S; Kitajima, M; Kawamura, K

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 1 ) page: 15 - 39   2024.1

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  6. Risk factors for non-previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan

    Matsuo, S; Kotani, T; Tano, S; Ushida, T; Imai, K; Nakamura, T; Osuka, S; Goto, M; Osawa, M; Asada, Y; Kajiyama, H

    REPRODUCTIVE MEDICINE AND BIOLOGY   Vol. 23 ( 1 ) page: e12592   2024.1

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  7. Rheological characterization of human follicular fluid under shear and extensional stress conditions

    Muto, M; Kikuchi, K; Yoshino, T; Muraoka, A; Iwata, S; Nakamura, M; Osuka, S; Tamano, S

    FRONTIERS IN PHYSICS   Vol. 11   2023.12

  8. Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts

    Muraoka Ayako, Suzuki Miho, Hamaguchi Tomonari, Watanabe Shinya, Iijima Kenta, Murofushi Yoshiteru, Shinjo Keiko, Osuka Satoko, Hariyama Yumi, Ito Mikako, Ohno Kinji, Kiyono Tohru, Kyo Satoru, Iwase Akira, Kikkawa Fumitaka, Kajiyama Hiroaki, Kondo Yutaka

    SCIENCE TRANSLATIONAL MEDICINE   Vol. 15 ( 700 ) page: eadd1531   2023.6

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  9. Follicle development and its prediction in patients with primary ovarian insufficiency: Possible treatments and markers to maximize the ability to conceive with residual follicles

    Osuka, S; Kasahara, Y; Iyoshi, S; Sonehara, R; Myake, N; Muraoka, A; Nakamura, T; Iwase, A; Kajiyama, H

    REPRODUCTIVE MEDICINE AND BIOLOGY   Vol. 22 ( 1 )   2023.1

  10. Association Between Anti-Mullerian Hormone Levels and Polycystic Ovarian Syndrome in a General Cohort of Young Women in Japan

    Miyake Natsuki, Osuka Satoko, Goto Maki, Seki Tomomi, Muraoka Ayako, Nakanishi Natsuki, Nakamura Tomoko, Iwase Akira, Kajiyama Hiroaki

    REPRODUCTIVE SCIENCES   Vol. 30   page: 172A - 172A   2023.1

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  11. Unkeito (Wen-jing-tang) Decreases Ovulation Disorder in a Rat Model of Polycystic Ovary Syndrome

    Osuka Satoko, Yoshita Sayako, Shimizu Tomofumi, Matsumoto Chinami, Seki Tomomi, Miyake Natsuki, Sonehara Reina, Muraoka Ayako, Nananishi Natsuki, Nakamura Tomoko, Kajiyama Hiroaki

    REPRODUCTIVE SCIENCES   Vol. 30   page: 250A - 251A   2023.1

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  12. Serum leucine-rich & alpha;2-glycoprotein as a possible marker for inflammatory status in endometriosis

    Kobayashi Mio, Nakamura Orie, Kitahara Yoshikazu, Inoue Naoki, Tsukui Yumiko, Hasegawa Yuko, Hiraishi Hikaru, Yabuki Atsushi, Muraoka Ayako, Osuka Satoko, Iwase Akira

    REPRODUCTIVE MEDICINE AND BIOLOGY   Vol. 22 ( 1 ) page: e12536   2023.1

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  13. Unkeito promotes follicle development by restoring reduced follicle-stimulating hormone responsiveness in rats with polycystic ovary syndrome.

    Yoshita S, Osuka S, Shimizu T, Fujitsuka N, Matsumoto C, Bayasula, Miyake N, Muraoka A, Nakanishi N, Nakamura T, Goto M, Kajiyama H

    Frontiers in endocrinology   Vol. 14   page: 1228088   2023

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    DOI: 10.3389/fendo.2023.1228088

    PubMed

  14. Upregulated Ribosomal Pathway Impairs Follicle Development in a Polycystic Ovary Syndrome Mouse Model: Differential Gene Expression Analysis of Oocytes

    Nakanishi Natsuki, Osuka Satoko, Kono Tomohiro, Kobayashi Hisato, Ikeda Shinya, Bayasula Bayasula, Sonehara Reina, Murakami Mayuko, Yoshita Sayako, Miyake Natsuki, Muraoka Ayako, Kasahara Yukiyo, Murase Tomohiko, Nakamura Tomoko, Goto Maki, Iwase Akira, Kajiyama Hiroaki

    REPRODUCTIVE SCIENCES     2022.10

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  15. Predictive factors for massive hemorrhage in women with retained products of conception: a prospective study

    Sonehara Reina, Nakamura Tomoko, Iwase Akira, Nishida Kazuki, Takikawa Sachiko, Murakami Mayuko, Yoshita Sayako, Muraoka Ayako, Miyake Natsuki, Nakanishi Natsuki, Osuka Satoko, Goto Maki, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 11859   2022.7

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  16. Anti-M?llerian hormone levels in the diagnosis of adolescent polycystic ovarian syndrome: a systematic review and meta-analysis

    Tsukui Yumiko, Kitahara Yoshikazu, Hasegawa Yuko, Kobayashi Mio, Osuka Satoko, Iwase Akira

    ENDOCRINE JOURNAL   Vol. 69 ( 8 ) page: 897 - 906   2022.6

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  17. Pregnancy Outcomes in Women with Thyroid Diseases.

    Kotani T, Imai K, Ushida T, Moriyama Y, Nakano-Kobayashi T, Osuka S, Tsuda H, Sumigama S, Yamamoto E, Kinoshita F, Hirakawa A, Iwase A, Kikkawa F, Kajiyama H

    JMA journal   Vol. 5 ( 2 ) page: 216 - 223   2022.4

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    DOI: 10.31662/jmaj.2021-0191

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  18. Effectiveness of NLRP3 Inhibitor as a Non-Hormonal Treatment for ovarian endometriosis

    Murakami Mayuko, Osuka Satoko, Muraoka Ayako, Hayashi Shotaro, Bayasula, Kasahara Yukiyo, Sonehara Reina, Hariyama Yumi, Shinjo Kanako, Tanaka Hideaki, Miyake Natsuki, Yoshita Sayako, Nakanishi Natsuki, Nakamura Tomoko, Goto Maki, Kajiyama Hiroaki

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 20 ( 1 ) page: 58   2022.3

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  19. Functional Lactotrophs in Induced Adenohypophysis Differentiated From Human iPS Cells

    Miyake Natsuki, Nagai Takashi, Suga Hidetaka, Osuka Satoko, Kasai Takatoshi, Sakakibara Mayu, Soen Mika, Ozaki Hajime, Miwata Tsutomu, Asano Tomoyoshi, Kano Mayuko, Muraoka Ayako, Nakanishi Natsuki, Nakamura Tomoko, Goto Maki, Yasuda Yoshinori, Kawaguchi Yohei, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Hagiwara Daisuke, Iwama Shintaro, Iwase Akira, Inoshita Naoko, Arima Hiroshi, Kajiyama Hiroaki

    ENDOCRINOLOGY   Vol. 163 ( 3 )   2022.3

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  20. Tamoxifen Activates Dormant Primordial Follicles in Mouse Ovaries

    Wei Wei, Komatsu Kouji, Osuka Satoko, Murase Tomohiko, Bayasula Bayasula, Nakanishi Natsuki, Nakamura Tomoko, Goto Maki, Iwase Akira, Masubuchi Satoru, Kajiyama Hiroaki

    REPRODUCTIVE SCIENCES     2022.2

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  21. Effect of hypothyroidism and thyroid autoimmunity on the ovarian reserve: A systematic review and meta-analysis.

    Hasegawa Y, Kitahara Y, Osuka S, Tsukui Y, Kobayashi M, Iwase A

    Reproductive medicine and biology   Vol. 21 ( 1 ) page: e12427   2022.1

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    DOI: 10.1002/rmb2.12427

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  22. Guidelines for Reproductive Medicine in Japan

    Yamada Mitsutoshi, Ishikawa Tomonori, Iwasa Takeshi, Oishi Hajime, Osuka Satoko, Oka Kenji, Ono Shuichi, Ono Masanori, Orisaka Makoto, Kanasaki Haruhiko, Kawano Yasushi, Kawamura Kazuhiro, Kishi Hiroshi, Kimura Fuminori, Kuroda Shinnosuke, Kuwahara Akira, Kobayashi Hideyuki, Komiya Akira, Saito Hidekazu, Sato Kenji, Sato Suguru, Shiraishi Koji, Shirasawa Hiromitsu, Suzuki Tatsuya, Takai Yasushi, Takae Seido, Takahashi Toshifumi, Takiuchi Tsuyoshi, Tachibana Masahito, Tamura Isao, Tamura Hiroshi, Jwa Seung Chik, Baba Tsuyoshi, Harada Miyuki, Hirata Tetsuya, Fukui Atsushi, Fukuda Yusuke, Fukuhara Shinichiro, Maruyama Tetsuo, Yumura Yasushi, Yoshino Osamu, Hirota Yasushi, Tsujimura Akira, Kuji Naoaki, Osuga Yutaka

    REPRODUCTIVE MEDICINE AND BIOLOGY   Vol. 21 ( 1 ) page: e12483   2022.1

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  23. Phosphate Burden and Inflammation.

    Erem AS, Osuka S, Razzaque MS

    Advances in experimental medicine and biology   Vol. 1362   page: 7 - 13   2022

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    DOI: 10.1007/978-3-030-91623-7_2

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  24. Anti-Mullerian hormone levels in the diagnosis of adolescent polycystic ovarian syndrome: a systematic review and meta-analysis

    Tsukui Yumiko, Kitahara Yoshikazu, Hasegawa Yuko, Kobayashi Mio, Osuka Satoko, Iwase Akira

    ENDOCRINE JOURNAL   Vol. 69 ( 8 ) page: 897 - 906   2022

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  25. Impact of perioperative use of GnRH agonist or dienogest on ovarian reserve after cystectomy for endometriomas: a randomized controlled trial

    Muraoka Ayako, Osuka Satoko, Yabuki Atsushi, Bayasula, Yoshihara Masato, Tanaka Hideaki, Sonehara Reina, Miyake Natsuki, Murakami Mayuko, Yoshita Sayako, Nakanishi Natsuki, Nakamura Tomoko, Goto Maki, Iwase Akira, Kajiyama Hiroaki

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 19 ( 1 ) page: 179   2021.12

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  26. Recent Insights into Human Endometrial Peptidases in Blastocyst Implantation via Shedding of Microvesicles

    Yoshihara Masato, Mizutani Shigehiko, Kato Yukio, Matsumoto Kunio, Mizutani Eita, Mizutani Hidesuke, Fujimoto Hiroki, Osuka Satoko, Kajiyama Hiroaki

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 22 ( 24 )   2021.12

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  27. Primate-specific POTE-actin gene could play a role in human folliculogenesis by controlling the proliferation of granulosa cells

    Kasahara Yukiyo, Osuka Satoko, Takasaki Nobuyoshi, Bayasula, Koya Yoshihiro, Nakanishi Natsuki, Murase Tomohiko, Nakamura Tomoko, Goto Maki, Iwase Akira, Kajiyama Hiroaki

    CELL DEATH DISCOVERY   Vol. 7 ( 1 ) page: 186   2021.7

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  28. Trisomy 5p with bilateral congenital diaphragmatic hernia: a case report

    Nakamura Noriyuki, Ushida Takafumi, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Osuka Satoko, Goto Maki, Kajiyama Hiroaki, Asada Hideyuki, Hayakawa Masahiro, Kotani Tomomi

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 15 ( 1 ) page: 114   2021.3

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  29. Establishment and characterization of cell lines from human endometrial epithelial and mesenchymal cells from patients with endometriosis.

    Muraoka A, Osuka S, Kiyono T, Suzuki M, Yokoi A, Murase T, Nishino K, Niimi K, Nakamura T, Goto M, Kajiyama H, Kondo Y, Kikkawa F

    F&S science   Vol. 1 ( 2 ) page: 195 - 205   2020.11

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    DOI: 10.1016/j.xfss.2020.09.001

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  30. Involvement of Transcription Factor 21 in the Pathogenesis of Fibrosis in Endometriosis.

    Ganieva U, Nakamura T, Osuka S, Bayasula, Nakanishi N, Kasahara Y, Takasaki N, Muraoka A, Hayashi S, Nagai T, Murase T, Goto M, Iwase A, Kikkawa F

    The American journal of pathology   Vol. 190 ( 1 ) page: 145 - 157   2020.1

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    DOI: 10.1016/j.ajpath.2019.09.008

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  31. Reduced response to controlled ovarian stimulation after radical trachelectomy: A pitfall of fertility-sparing surgery for cervical cancer

    Tamauchi Satoshi, Kajiyama Hiroaki, Osuka Satoko, Moriyama Yoshinori, Yoshihara Masato, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS     2021.1

  32. Very Low Levels of Serum Anti-Mullerian Hormone as a Possible Marker for Follicle Growth in Patients with Primary Ovarian Insufficiency Under Hormone Replacement Therapy

    Kasahara Yukiyo, Osuka Satoko, Bayasula, Nakanishi Natsuki, Murase Tomohiko, Nakamura Tomoko, Goto Maki, Kotani Tomomi, Iwase Akira, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 28 ( 1 ) page: 31 - 36   2021.1

  33. Focal Adhesion Kinase-Mediated Sequences, Including Cell Adhesion, Inflammatory Response, and Fibrosis, as a Therapeutic Target in Endometriosis

    Nagai Takashi, Ishida Chiharu, Nakamura Tomoko, Iwase Akira, Mori Masahiko, Murase Tomohiko, Bayasula, Osuka Satoko, Takikawa Sachiko, Goto Maki, Kotani Tomomi, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( 7 ) page: 1400 - 1410   2020.7

  34. Expressions and Effects of Phoenixin and Its Receptor GPR173 During the Human Menstrual Cycle.

    Xuan Phuoc Nguyen, Nakamura Tomoko, Osuka Satoko, Bayasula Bayasula, Muraoka Ayako, Hayashi Shotaro, Nakanishi Natsuki, Kasahara Yukiyo, Murase Tomohiko, Goto Maki, Iwase Akira, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( SUPPL 1 ) page: 281A - 281A   2020.3

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  35. Exogenous Anti-AMHRII Antibody Treatment Induces Follicular Development in Sliced Ovarian Tissue Cultures.

    Murase Tomohiko, Komatsu Kouji, Wei Wei, Sonehara Reina, Miyake Natsuki, Murakami Mayuko, Umida Ganieva, Bayasula Bayasula, Yoshita Sayako, Muraoka Ayako, Hayashi Shotaro, Nakanishi Natsuki, Kasahara Yukiyo, Nguyen Phuoc X., Takasaki Nobuyoshi, Nakamura Tomoko, Osuka Satoko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( SUPPL 1 ) page: 367A - 367A   2020.3

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  36. Effect of Unkeito, a Traditional Herbal Medicine, on a Rat Model of Polycystic Ovary Syndrome.

    Yoshita Sayako, Osuka Satoko, Sonehara Reina, Miyake Natsuki, Murakami Mayuko, Wei Wei, Hayashi Shotaro, Muraoka Ayako, Ganieva Umida, Nakanishi Natsuki, Kasahara Yukiyo, Bayasula Bayasula, Takasaki Nobuyoshi, Murase Tomohiko, Nakamura Tomoko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( SUPPL 1 ) page: 191A - 192A   2020.3

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  37. Discovery and Quantification of Novel Markers of Primary Ovarian Insufficiency.

    Osuka Satoko, Kasahara Yukiyo, Takasaki Nobuyoshi, Sula Baya, Yoshita Sayako, Nakanishi Natsuki, Murase Tomohiko, Nakamura Tomoko, Goto Maki, Iwase Akira, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( SUPPL 1 ) page: 358A - 358A   2020.3

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  38. Differential Gene Expression and DNA Methylation Analysis of Oocytes from a Mouse Model of Polycystic Ovarian Syndrome.

    Nakanishi Natsuki, Osuka Satoko, Sonehara Reina, Miyake Natsuki, Murakami Mayuko, Wei Wei, Ganieva Umida, Hayashi Shotaro, Muraoka Ayako, Yoshita Sayako, Kasahara Yukiyo, Bayasula Bayasula, Takasaki Nobuyoshi, Murase Tomohiko, Nakamura Tomoko, Maki Goto, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( SUPPL 1 ) page: 272A - 273A   2020.3

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  39. Primary Follicles Suppress the Growth of Primordial Follicles.

    Wei Wei, Komatsu Kouji, Murase Tomohiko, Sonehara Reina, Miyake Natsuki, Murakami Mayuko, Ganieva Umida, Bayasula Bayasula, Yoshita Sayako, Muraoka Ayako, Hayashi Shotaro, Nakanishi Natsuki, Kasahara Yukiyo, Takasaki Nobuyoshi, Nakamura Tomoko, Osuka Satoko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( SUPPL 1 ) page: 283A - 283A   2020.3

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  40. The Function of POTEF in Human Granulosa Cells, an Antigen for Ovarian Autoimmunity, in POI Patients.

    Kasahara Yukiyo, Osuka Satoko, Takasaki Nobuyoshi, Wei Wei, Nakanishi Natsuki, Bayasula Bayasula, Nakamura Tomoko, Murase Tomohiko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( SUPPL 1 ) page: 199A - 199A   2020.3

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  41. Involvement of Transcription Factor 21 in the Pathogenesis of Fibrosis in Endometriosis

    Ganieva Umida, Nakamura Tomoko, Osuka Satoko, Bayasula, Nakanishi Natsuki, Kasahara Yukiyo, Takasaki Nobuyoshi, Muraoka Ayako, Hayashi Shotaro, Nagai Takashi, Murase Tomohiko, Goto Maki, Iwase Akira, Kikkawa Fumitaka

    AMERICAN JOURNAL OF PATHOLOGY   Vol. 190 ( 1 ) page: 145 - 157   2020.1

  42. Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations

    Inoue Satoshi, Hirota Yasushi, Ueno Toshihide, Fukui Yamato, Yoshida Emiko, Hayashi Takuo, Kojima Shinya, Takeyama Reina, Hashimoto Taiki, Kiyono Tohru, Ikemura Masako, Taguchi Ayumi, Tanaka Tomoki, Tanaka Yosuke, Sakata Seiji, Takeuchi Kengo, Muraoka Ayako, Osuka Satoko, Saito Tsuyoshi, Oda Katsutoshi, Osuga Yutaka, Terao Yasuhisa, Kawazu Masahito, Mano Hiroyuki

    NATURE COMMUNICATIONS   Vol. 10   2019.12

  43. REDUCED RESPONSE TO CONTROLLED OVARIAN STIMULATION AFTER RADICAL TRACHELECTOMY

    Tamauchi S., Kajiyama H., Osuka S., Moriyama Y., Yoshihara M., Iyoshi S., Yoshida K., Ikeda Y., Yoshikawa N., Nishino K., Niimi K., Suzuki S., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29   page: A269 - A270   2019.11

  44. Adverse effects of endometriosis on pregnancy: a case-control study

    Miura Mayo, Ushida Takafumi, Imai Kenji, Wang Jingwen, Moriyama Yoshinori, Nakano-Kobayashi Tomoko, Osuka Satoko, Kikkawa Fumitaka, Kotani Tomomi

    BMC PREGNANCY AND CHILDBIRTH   Vol. 19 ( 1 )   2019.10

  45. Upregulation of Fibroblast Growth Factors Caused by Heart and Neural Crest Derivatives Expressed 2 Suppression in Endometriotic Cells: A Possible Therapeutic Target in Endometriosis.

    Kato N, Iwase A, Ishida C, Nagai T, Mori M, Bayasula, Nakamura T, Osuka S, Ganiyeva U, Qin Y, Miki R, Kikkawa F

    Reproductive sciences (Thousand Oaks, Calif.)   Vol. 26 ( 7 ) page: 979 - 987   2019.7

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    DOI: 10.1177/1933719118802053

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  46. Effect of the neuropeptide phoenixin and its receptor GPR173 during folliculogenesis

    Xuan Phuoc Nguyen, Nakamura Tomoko, Osuka Satoko, Bayasula Bayasula, Nakanishi Natsuki, Kasahara Yukiyo, Muraoka Ayako, Hayashi Shotaro, Nagai Takashi, Murase Tomohiko, Goto Maki, Iwase Akira, Kikkawa Fumitaka

    REPRODUCTION   Vol. 158 ( 1 ) page: 25 - 34   2019.7

  47. Molecular mechanism of FSHR expression induced by BMP15 in human granulosa cells

    Shimizu Ken, Nakamura Tomoko, Bayasula, Nakanishi Natsuki, Kasahara Yukiyo, Nagai Takashi, Murase Tomohiko, Osuka Satoko, Goto Maki, Iwase Akira, Kikkawa Fumitaka

    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS   Vol. 36 ( 6 ) page: 1185 - 1194   2019.6

  48. Animal models of polycystic ovary syndrome: A review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides

    Osuka Satoko, Nakanishi Natsuki, Murase Tomohiko, Nakamura Tomoko, Goto Maki, Iwase Akira, Kikkawa Fumitaka

    REPRODUCTIVE MEDICINE AND BIOLOGY   Vol. 18 ( 2 ) page: 151 - 160   2019.4

  49. Protective effects of mangafodipir against chemotherapy-induced ovarian damage in mice

    Qin Ying, Iwase Akira, Murase Tomohiko, Bayasula, Ishida Chiharu, Kato Nao, Nakamura Tomoko, Osuka Satoko, Takikawa Sachiko, Goto Maki, Kotani Tomomi, Kikkawa Fumitaka

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 16 ( 1 ) page: 106   2018.10

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    DOI: 10.1186/s12958-018-0426-y

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  50. TCF21 REGULATION OF PERIOSTIN IN THE PROGRESSION OF ENDOMETRIOTIC FIBROSIS.

    Ganieva U., Nakamura T., Nguyen P. X., Wei W., Murakami M., Miyake N., Nakanishi N., Kasahara Y., Takasaki N., Muraoka A., Hayashi S., Nagai T., Murase T., Osuka S., Goto M., Iwase A.

    FERTILITY AND STERILITY   Vol. 110 ( 4 ) page: E393-E393   2018.9

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  51. Neuropeptide phoenixin (PNX) and its novel receptor GPR173 induce COX-1/COX-2 expression and PGE2 production through the CREB signaling pathway

    Nguyen X. P., Iwase A., Murase T., Ganieva U., Qin Y., Bayasula B., Shimizu K., Osuka S., Nakamura T., Goto M., Kikkawa F.

    HUMAN REPRODUCTION   Vol. 33   page: 287-287   2018.7

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  52. Thyroid Autoantibodies do not Impair the Ovarian Reserve in Euthyroid Infertile Women: A Cross-Sectional Study

    Osuka Satoko, Iwase Akira, Goto Maki, Takikawa Sachiko, Nakamura Tomoko, Murase Tomohiko, Kato Nao, Bayasula, Kotani Tomomi, Kikkawa Fumitaka

    HORMONE AND METABOLIC RESEARCH   Vol. 50 ( 7 ) page: 537 - 542   2018.7

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    DOI: 10.1055/a-0637-9430

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  53. Clinical application of serum anti-Mullerian hormone as an ovarian reserve marker: A review of recent studies

    Iwase Akira, Osuka Satoko, Goto Maki, Murase Tomohiko, Nakamura Tomoko, Takikawa Sachiko, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 44 ( 6 ) page: 998 - 1006   2018.6

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    DOI: 10.1111/jog.13633

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  54. Directive Action of Neuropeptide Phoenixin and Its Receptor GPR173 during Folliculogenesis.

    Nguyen Phuoc X., Iwase Akira, Murase Tomohiko, Ganieva Umida, Qin Ying, Bayasula Bayasula, Shimizu Ken, Osuka Satoko, Nakamura Tomoko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 25   page: 321A-322A   2018.3

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  55. Exogenous GDF-9 Treatment Induces Follicular Development through Downregulation of Anti-Mullerian Hormone Receptor as Visualized in the Sliced Ovarian Tissue Culture System.

    Murase Tomohiko, Iwase Akira, Komatsu Kouji, Wei Wei, Ganieva Umida, Bayasula Bayasula, Nguyen Phuoc X., Yoshita Sayako, Qin Ying, Muraoka Ayako, Hayashi Shotaro, Kasahara Yukiyo, Nakanishi Natsuki, Nagai Takashi, Shimizu Ken, Ishida Chiharu, Nakamura Tomoko, Osuka Satoko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 25   page: 177A-177A   2018.3

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  56. Follicle dynamics: visualization and analysis of follicle growth and maturation using murine ovarian tissue culture.

    Murase T, Iwase A, Komatsu K, Bayasula, Nakamura T, Osuka S, Takikawa S, Goto M, Kotani T, Kikkawa F

    Journal of assisted reproduction and genetics   Vol. 35 ( 2 ) page: 339 - 343   2018.2

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    DOI: 10.1007/s10815-017-1073-5

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  57. Retrospective analysis of magnetic resonance imaging for differentiating intraligamentous leiomyomas from subserosal leiomyomas

    Shimizu Ken, Iwase Akira, Sakurai Yusuke, Nakamura Tomoko, Osuka Satoko, Takikawa Sachiko, Goto Maki, Kikkawa Fumitaka

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 215   page: 256 - 257   2017.8

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    DOI: 10.1016/j.ejogrb.2017.06.046

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  58. Mass Spectrometry Analysis of Ovarian Autoimmunity in Spontaneous Primary Ovarian Insufficiency (POI) Patients.

    Osuka Satoko, Iwase Akira, Kasahara Yukiyo, Murase Tomohiko, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 24   page: 292A-293A   2017.3

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  59. Growth Differentiation Factor 9 Induces Granulosa Cell Proliferation via Inhibition of the Expression of AMH Type II Receptor.

    Iwase Akira, Osuka Satoko, Bayasula Bayasula, Takikawa Sachiko, Murase Tomohiko, Nakamura Tomoko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 24   page: 163A-163A   2017.3

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  60. Analysis of Follicular Growth and Oocyte Maturation in Cultured Murine Ovarian Tissue.

    Murase Tomohiko, Iwase Akira, Nguyen Phuoc Xuan, Ganieva Umida, Qin Ying, Nakanishi Natsuki, Kasahara Yukiyo, Nagai Takashi, Shimizu Ken, Ishida Chiharu, Kato Nao, Osuka Satoko, Nakamura Tomoko, Takikawa Sachiko, Goto Maki, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 24   page: 292A-292A   2017.3

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  61. Kisspeptin in the Hypothalamus of 2 Rat Models of Polycystic Ovary Syndrome

    Osuka Satoko, Iwase Akira, Nakahara Tatsuo, Kondo Mika, Saito Ai, Bayasula, Nakamura Tomoko, Takikawa Sachiko, Goto Maki, Kotani Tomomi, Kikkawa Fumitaka

    ENDOCRINOLOGY   Vol. 158 ( 2 ) page: 367 - 377   2017.2

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    DOI: 10.1210/en.2016-1333

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Presentations 3

  1. POIにおける卵胞発育の予見・予測

    大須賀智子、笠原幸代、岩瀬明、梶山広明

    第67回 日本生殖医学会学術講演会  2022.11.3 

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    Event date: 2022.11

    Presentation type:Symposium, workshop panel (nominated)  

  2. アンドロゲン曝露による キスペプチン/ゴナドトロピン分泌異常 と不妊症(多嚢胞性卵巣症候群)

    大須賀智子

    第36回 下垂体研究会学術集会  2022.8.6 

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    Event date: 2022.8

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  3. Diverse approaches provide novel non-hormonal therapies or proper hormonal therapies for endometriosis Invited International conference

    Osuka S, Muraoka A, Ishida C, Nagai T, Nakamura T, Murase T, Goto M, Iwase A, Kikkawa F

    Taiwan Endometriosis International Symposium and Taiwan Endometriosis Society 2019 Annual Meeting  2019.11.23 

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    Event date: 2019.11

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

Research Project for Joint Research, Competitive Funding, etc. 1

  1. インフラマソーム阻害に着目した新規非ホルモン性子宮内膜症治療薬の探索

    研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. Inflammaging-細胞老化を標的とした卵巣機能長寿化への挑戦

    Grant number:24K02583  2024.4 - 2028.3

    科学研究費助成事業  基盤研究(B)

    岩瀬 明, 北原 慈和, 大須賀 智子, 小松 紘司, 中村 智子, 小林 未央

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    女性における妊孕性は卵の質と量に依存している。加齢以外にも卵巣機能に影響を及ぼす疾患として、子宮内膜症、多嚢胞性卵巣症候群、自己免疫性甲状腺炎が知られており、それぞれ病因は異なるが卵巣局所の慢性炎症が共通病態である。本研究では慢性炎症による卵巣機能低下(ovarian inflammaging)と加齢による変化に共通する分子基盤として細胞老化に着目した検討を行う。上記3疾患のモデルマウスを作製し、ovarian inflammaging-細胞老化メカニズムを探索する。細胞老化を標的とした卵巣機能長寿化への介入方法の確立を目指し、in vitro, in vivo(モデルマウス)の解析を行う。

  2. 細胞老化からアプローチする子宮内膜症の病態解明と新規治療の確立

    Grant number:23K08820  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    中村 智子, 岩瀬 明, 大須賀 智子, 仲西 菜月

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    本研究では顆粒膜細胞株HGrC1や卵巣内膜症モデルマウスを用い、老化とパラクライン老化が内膜症性不妊をきたす機序を解明し、内膜症への細胞老化治療の有用性を調べる。
    具体的にはまず、内膜症病変中の老化細胞の発生と制御を検討する。細胞老化関連分泌形質(SASP)を同定するとともに、老化細胞が発生する段階や機序を検討する。
    次に、パラクライン老化の広がりや卵巣組織への影響について評価する。
    さらに、細胞老化治療が内膜症病変および卵胞発育に与える効果について評価する。
    これらの研究を通して、非ホルモン性の新規内膜症治療の確立を目指す。

  3. 早発卵巣不全予測マーカー測定法開発と妊孕性温存療法への展開

    Grant number:23K08865  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    大須賀 智子, 村岡 彩子, 三宅 菜月

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    昨今の不妊治療技術の向上により、これまで妊娠を諦めざるを得なかった不妊症の患者が子を持つことが可能となってきた。一方で、早発卵巣不全や加齢による妊孕能の低下等、現在の不妊治療でも克服できない問題もあり難治性不妊症と呼ばれる。早発卵巣不全は40歳未満で卵子が枯渇し閉経状態に至る疾患である。不可逆性であり一旦成立すると自身の卵子で妊娠することはほぼ不可能である。事前に予測できれば卵子凍結や卵巣組織凍結による妊孕性温存が技術的に可能であるが、現在そのようなマーカーはない。
    本研究は、新規妊孕能マーカーの測定によりこのような不可逆性不妊が成立する前にリスク例を検出することを目的とする。

  4. 新規自己抗体標的抗原に着目した自己免疫関連生殖機能障害の病態解明と早期診断法確立

    Grant number:20H03819  2020.4 - 2024.3

    岩瀬 明

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    不妊症・不育症には自己免疫疾患が合併することがあるが、その詳細は不明である。我々は患者血清中に存在する自己抗体とその標的タンパクProstate, ovary, testis, ankyrin domain family member F (POTEF)を同定した。POTEFは卵巣、胎盤に特異性高く発現し、自己免疫機序によるPOTEFの障害が卵巣機能不全、反復流産の病態であるという仮説をたてた。
    卵巣、胎盤におけるPOTEFの機能解析を行うとともに、抗POTE抗体をマウスに投与し、自己免疫機序による病態の再現が可能かどうか検証する。抗POTEF抗体のアッセイ系を用い臨床的検討もあわせて行う。

  5. リプロダクティブヘルスケア/ライツ啓発を組み入れた新規早発卵巣不全予測法の検証

    Grant number:20K11508  2020.4 - 2023.3

    後藤 真紀

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    若い世代への加齢による卵の質の低下や卵巣予備能の啓発は重要である。また早発卵巣不全という疾患は40 歳未満で 1-2/100の発症率と稀な疾患ではないが、原因不明であり発症後の治療や自己卵子での妊娠が非常に困難となる疾患である。本研究では講義形式のみの受動的な啓発手法に加えて、能動的に卵巣予備能を測定し自身の卵巣予備能について認識してもらう啓発プログラムの有効性を検証し、早発卵巣不全ハイリスク患者の抽出とリスク因子を解析することで、早発卵巣不全の早期発見を可能にするスクリーニング法の開発と検証を同時に行う。

  6. 顆粒膜細胞障害に着目した子宮内膜症における卵胞発育障害の解明

    Grant number:20K09615  2020.4 - 2023.3

    中村 智子

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    内膜症による卵胞発育障害の機序を、炎症と線維化による顆粒膜細胞障害から解明し、排卵を抑制しない新規内膜症治療薬の開発を目的とする。機序の解明に際し、効果的な阻害剤や補充療法を選定し、マウスモデルを用いて新規治療薬としての効果判定を行う。他疾患と共通する機序が見出されれば、既存の臨床治療薬が内膜症治療に応用可能か調べる。さらに内膜症に限らず、同じく線維化が主病態である卵巣の加齢・早発機能不全(POF)・がん生殖においても卵胞機能保全の方策の一助とする。

  7. 臓器連関に着目した多嚢胞性卵巣症候群の病態解析と新規治療法の開発

    Grant number:20K18217  2020.4 - 2023.3

    若手研究

    大須賀 智子

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    PCOSはその多彩な症状のため、病因の詳細は不明であるため対症療法が主であり、根本的な治療法の開発には至っていない。近年、糖質・脂質代謝調節などの疾患おいて臓器連関の関与が着目されており、多臓器で代謝異常や内分泌異常を呈するPCOSでは、このような臓器間のネットワークがその病態において重要な役割をもつ可能性が高い。本研究では、生殖生理・内分泌を制御する視床下部-下垂体-卵巣軸に加え、肝臓、筋肉、骨、消化管など、これらをとりまく複数の臓器から分泌される因子に着目した解析により、新規治療につながるようなPCOSの病態解明をめざす。

  8. 胎児環境によるエピジェネティック変化を標的としたPCOS新規治療法の開発

    Grant number:17K16844  2017.4 - 2021.3

    大須賀 智子

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    多嚢胞性卵巣症候群 (PCOS) の新規治療ターゲットを解析するため、胎生期アンドロゲン投与により作成したPCOSモデルについて、DNAメチル化変化に着目し、これまでヒトやモデル動物で網羅的な解析の行われていない臓器である視床下部と肝臓における解析を行った。
    モデルラットは胎生16-19日目に経母体DHT投与により作成した。PCOS様表現型として、性周期の異常と血清LH (luteinizing hormone) 値高値、卵巣の多嚢胞化所見を確認した。視床下部と肝臓について、DNAメチル化解析、RNA-seqによる遺伝子発現変動の解析を施行した。
    プロモーター領域のDNAメチル化変化の解析では、モデルにおいてコントロールに比して高メチル化を示した遺伝子は視床下部で500、肝臓で200、内共通する遺伝子は20であった。低メチル化を示した遺伝子は視床下部で424、肝臓で186、内共通する遺伝子は12であった。RNA-seqにおける発現変動遺伝子 (FC>2, p<0.05) 数は視床下部で12、肝臓で57、内共通したものは3遺伝子であった。視床下部と肝臓で共通して変化を示した遺伝子では、メチル化変化と発現変動遺伝子との関連は示されなかった。メチル化変化と発現変動を示した遺伝子は、視床下部でVglut1 (高メチル化/発現低下)、Bcmo1 (低メチル化/発現低下)が認められた。さらに、肝臓のRNA-seqにおいて、遺伝子発現変動のみられたアディポカイン・ヘパトカインにLect2、Rbp4が認められた。このうちRBP4は、ELISA (enzyme-linked immunosorbent assay) にて血清濃度の上昇が確認された。
    モデル動物の作成と、DNAメチル化解析、RNA-seqによる発現解析とそれらの比較を施行し、治療標的となる可能性のある分子の候補を選出することができた。一方で、当該分子についてのヒト検体を用いた解析や、モデル動物等を用いた治療薬候補の検討までは至らなかったため。
    これまでのモデル動物を用いた検討により、メチル化変化と発現変動を示した遺伝子は、視床下部ではVglut1 (高メチル化/発現低下)、Bcmo1 (低メチル化/発現低下)であった。VGLUT1-positive glutamatergic neuronはストレス反応における褐色脂肪細胞の熱産生やGnRHニューロンの制御に関連するという報告がある。またBCMO1の遺伝子多型とPCOSの関連の報告がある。さらに、肝臓のRNA-seqにおいて、遺伝子発現変動のみられたアディポカイン・ヘパトカインにLect2、Rbp4が認められた。このうちRBP4は、ELISA (enzyme-linked immunosorbent assay) にて血清濃度の上昇が確認された。RBP4はヒトPCOSにおける血中濃度の上昇の報告がある。またPioglitazoneやfenretinideなどの下降剤がある。
    これらのモデルにおいて変化の認められた分子を対象に、今後ヒト検体を用いた評価や、モデル動物によるin vivo,ヒト由来の組織や細胞を用いたex vivoやin vitroの解析を行い、治療標的としての解析を行いたい。

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Teaching Experience (On-campus) 2

  1. 選択特別講義 産婦人科医療の発展と課題

    2023

  2. 臓器別臨床講義 産婦人科学

    2023

 

Social Contribution 1

  1. 愛知県不妊不育相談センター 公開講座

    Role(s):Advisor, Organizing member

    2023.1