Updated on 2021/11/02

写真a

 
FURUKAWA Takako
 
Organization
Graduate School of Medicine Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Professor

Degree 1

  1. 薬学博士 ( 1990.9   京都大学 ) 

Research Interests 2

  1. Radiopharmaceuticals

  2. Molecular Imaging

Research Areas 3

  1. Others / Others  / Molecular Imaging

  2. Life Science / Radiological sciences

  3. Life Science / Pharmaceutical analytical chemistry and physicochemistry

Research History 4

  1. Team Leader, Molecular Imaging Center, National Institute of Radiological Sciences

    2006.3 - 2016.3

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    Country:Japan

  2. Associate Professor, Biomedical Imaging Research Center, University of Fukui

    2002.1 - 2006.2

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    Country:Japan

  3. 関西医科大学 衛生学教室 講師

    2000.10 - 2001.12

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    Country:Japan

  4. Research associate, Department of Hygene, Kansai Medical School

    1989.10 - 2000.9

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    Country:Japan

Education 2

  1. Kyoto University   Graduate School, Division of Pharmaceutical Sciences

    1983.4 - 1985.3

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    Country: Japan

  2. Kyoto University   Faculty of Pharmaceutical Science

    1979.4 - 1983.3

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    Country: Japan

Professional Memberships 6

  1. 日本核医学会

  2. 日本分子イメージング学会

  3. 日本癌学会

  4. Society of Nuclear Medicine

  5. World Molecular Imaging Sciety

  6. Society of Radiopharmaceutical Sciences

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Papers 78

  1. Copper-64-Labeled Antibody Fragments for Immuno-PET/ Radioimmunotherapy with Low Renal Radioactivity Levels and Amplified Tumor -Kidney Ratios

    Suzuki Hiroyuki, Kise Shota, Kaizuka Yuta, Watanabe Reo, Sugawa Tsubasa, Furukawa Takako, Fujii Hirofumi, Uehara Tomoya

    ACS OMEGA   Vol. 6 ( 33 ) page: 21556 - 21562   2021.8

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  2. Effect of Gold Nanoparticle Radiosensitization on Plasmid DNA Damage Induced by High-Dose-Rate Brachytherapy Reviewed International journal

    Yogo Katsunori, Misawa Masaki, Shimizu Morihito, Shimizu Hidetoshi, Kitagawa Tomoki, Hirayama Ryoichi, Ishiyama Hiromichi, Furukawa Takako, Yasuda Hiroshi

    INTERNATIONAL JOURNAL OF NANOMEDICINE   Vol. 16   page: 359 - 370   2021

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.2147/IJN.S292105

    Web of Science

    PubMed

  3. Imaging of bremsstrahlung X-rays from tritium water in a plastic bag using a LaGPS radiation imaging system Reviewed International journal

    Yamamoto S., Nakanishi K., Furukawa T., Tomita H., Kamada K., Yoshikawa A.

    JOURNAL OF INSTRUMENTATION   Vol. 15 ( 4 )   2020.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1088/1748-0221/15/04/P04006

    Web of Science

  4. Possibility analysis of bremsstrahlung x-ray imaging of C-14 radionuclide using a LaGPS radiation imaging system

    Yamamoto Seiichi, Nakanishi Kouhei, Furukawa Takako, Tomita Hideo

    BIOMEDICAL PHYSICS & ENGINEERING EXPRESS   Vol. 5 ( 3 )   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1088/2057-1976/ab12bd

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  5. Positron emission tomography of cerebral angiogenesis and TSPO expression in a mouse model of chronic hypoxia. Reviewed International coauthorship International journal

    Kanno I, Seki C, Takuwa H, Jin ZH, Boturyn D, Dumy P, Furukawa T, Saga T, Ito H, Masamoto K

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism   Vol. 38 ( 4 ) page: 687 - 696   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0271678X16689800

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  6. Combined treatment of pancreatic cancer xenograft with <sup>90</sup>Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor. Reviewed International journal

    Aung W, Tsuji AB, Sudo H, Sugyo A, Ukai Y, Kouda K, Kurosawa Y, Furukawa T, Saga T, Higashi T

    World journal of gastroenterology   Vol. 23 ( 42 ) page: 7551 - 7562   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3748/wjg.v23.i42.7551

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  7. <sup>64</sup>Cu-ATSM internal radiotherapy to treat tumors with bevacizumab-induced vascular decrease and hypoxia in human colon carcinoma xenografts. Reviewed International journal

    Yoshii Y, Yoshimoto M, Matsumoto H, Furukawa T, Zhang MR, Inubushi M, Tsuji AB, Fujibayashi Y, Higashi T, Saga T

    Oncotarget   Vol. 8 ( 51 ) page: 88815 - 88826   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.21323

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  8. Improvement of therapeutic efficacy by combing 90Y-ITGA6B4-mediated radioimmunotherapy (RIT) with dual PI3K and mTOR inhibitor NVP-BEZ235

    Aung W., Tsuji A. B., Sudo H., Sugyo A., Ukai Y., Kouda K., Kurosawa Y., Furukawa T., Saga T., Higashi T.

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   Vol. 44   page: S767-S767   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  9. Cu-67-Radiolabeling of a multimeric RGD peptide for alpha(v)beta(3) integrin-targeted radionuclide therapy: stability, therapeutic efficacy, and safety studies in mice Reviewed International journal

    Jin Zhao-Hui, Furukawa Takako, Ohya Tomoyuki, Degardin Melissa, Sugyo Aya, Tsuji Atsushi B., Fujibayashi Yasuhisa, Zhang Ming-Rong, Higashi Tatsuya, Boturyn Didier, Dumy Pascal, Saga Tsuneo

    NUCLEAR MEDICINE COMMUNICATIONS   Vol. 38 ( 4 ) page: 347 - 355   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MNM.0000000000000646

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  10. αVβ3 Integrin-Targeted Radionuclide Therapy with 64Cu-cyclam-RAFT-c(-RGDfK-)4. Reviewed

    Jin ZH, Furukawa T, Degardin M, Sugyo A, Tsuji AB, Yamasaki T, Kawamura K, Fujibayashi Y, Zhang MR, Boturyn D, Dumy P, Saga T.

    Molecular Cancer Therapeutics   Vol. 15 ( 9 ) page: 2076-2085   2016.9

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  11. αVβ3 Integrin-Targeted Radionuclide Therapy with 64Cu-cyclam-RAFT-c(-RGDfK-)4. Reviewed

      Vol. 15 ( 9 ) page: 2076-85   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/1535-7163.MCT-16-0040

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  12. (64)Cu-ATSM therapy targets regions with activated DNA repair and enrichment of CD133(+) cells in an HT-29 tumor model: Sensitization with a nucleic acid antimetabolite. Reviewed

    Yoshii Y, Furukawa T, Matsumoto H, Yoshimoto M, Kiyono Y, Zhang MR, Fujibayashi Y, Saga T.

    Cancer Letters   Vol. 376 ( 1 ) page: 74-82   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.canlet.2016.03.020

  13. Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90Y-labeled anti-α6β4 integrin antibody. Reviewed

      Vol. 7 ( 25 ) page: 38835-38844   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.9631

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  14. Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90Y-labeled anti-α6β4 integrin antibody. Reviewed

    Aung W, Tsuji AB, Sudo H, Sugyo A, Ukai Y, Kouda K, Kurosawa Y, Furukawa T, Saga T.

    Oncotarget   Vol. 7 ( 25 ) page: 38835-38844   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.9631

  15. Regorafenib as a potential adjuvant chemotherapy agent in disseminated small colon cancer: Drug selection outcome of a novel screening system using nanoimprinting 3-dimensional culture with HCT116-RFP cells. Reviewed

    Yoshii Y, Furukawa T, Aoyama H, Adachi N, Zhang MR, Wakizaka H, Fujibayashi Y, Saga T

    International journal of oncology   Vol. 48 ( 4 ) page: 1477-84   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ijo.2016.3361

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  16. <sup>64</sup>Cu-ATSM therapy targets regions with activated DNA repair and enrichment of CD133<sup>+</sup> cells in an HT-29 tumor model: Sensitization with a nucleic acid antimetabolite. Reviewed

    Yoshii Y, Furukawa T, Matsumoto H, Yoshimoto M, Kiyono Y, Zhang MR, Fujibayashi Y, Saga T

    Cancer letters     2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.canlet.2016.03.020

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  17. Immunotargeting of Integrin α6β4 for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model. Reviewed

    Aung W, Tsuji AB, Sudo H, Sugyo A, Furukawa T, Ukai Y, Kurosawa Y, Saga T.

    Molecular Imaging     2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1536012115624917

  18. Immunotargeting of Integrin α6β4 for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model. Reviewed

      Vol. 15   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1536012115624917

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  19. Transcriptomic Signatures of Auger Electron Radioimmunotherapy Using Nuclear Targeting (111)In-Trastuzumab for Potential Combination Therapies. Reviewed

    Li HK, Morokoshi Y, Daino K, Furukawa T, Kamada T, Saga T, Hasegawa S

    Cancer biotherapy & radiopharmaceuticals   Vol. 30 ( 8 ) page: 349-58   2015.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/cbr.2015.1882

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  20. Validation of 64Cu-ATSM damaging DNA via high-LET Auger electron emission. Reviewed

    McMillan DD, Maeda J, Bell JJ, Genet MD, Phoonswadi G, Mann KA, Kraft SL, Kitamura H, Fujimori A, Yoshii Y, Furukawa T, Fujibayashi Y, Kato TA

    Journal of radiation research   Vol. 56 ( 5 ) page: 784-91   2015.9

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    DOI: 10.1093/jrr/rrv042

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  21. A limited overlap between intratumoral distribution of 1-(5-fluoro-5-deoxy-α-D-arabinofuranosyl)-2-nitroimidazole and copper-diacetyl-bis[N(4)-methylthiosemicarbazone]. Reviewed

      Vol. 34 ( 3 ) page: 1379-87   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/or.2015.4079

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  22. High-throughput screening with nanoimprinting 3D culture for efficient drug development by mimicking the tumor environment. Reviewed

    Yoshii Y, Furukawa T, Waki A, Okuyama H, Inoue M, Itoh M, Zhang MR, Wakizaka H, Sogawa C, Kiyono Y, Yoshii H, Fujibayashi Y, Saga T

    Biomaterials   Vol. 51   page: 278-89   2015.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biomaterials.2015.02.008

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  23. Quantifying initial cellular events of mouse radiation lymphomagenesis and its tumor prevention in vivo by positron emission tomography and magnetic resonance imaging. Reviewed

      Vol. 9 ( 3 ) page: 740-8   2015.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molonc.2014.11.009

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  24. Development of the Fibronectin-Mimetic Peptide KSSPHSRN(SG)5RGDSP as a Novel Radioprobe for Molecular Imaging of the Cancer Biomarker α5β1 Integrin. Reviewed

      Vol. 38 ( 11 ) page: 1722-31   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1248/bpb.b15-00344

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  25. Immuno-PET Imaging of HER3 in a Model in which HER3 Signaling Plays a Critical Role. Reviewed

    Yuan Q, Furukawa T, Tashiro T, Okita K, Jin ZH, Aung W, Sugyo A, Nagatsu K, Endo H, Tsuji AB, Zhang MR, Masuko T, Inoue M, Fujibayashi Y, Saga T

    PloS one   Vol. 10 ( 11 ) page: e0143076   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0143076

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  26. Molecular imaging of ectopic metabotropic glutamate 1 receptor in melanoma with a positron emission tomography radioprobe (18) F-FITM. Reviewed

    Xie L, Yui J, Fujinaga M, Hatori A, Yamasaki T, Kumata K, Wakizaka H, Furutsuka K, Takei M, Jin ZH, Furukawa T, Kawamura K, Zhang MR

    International journal of cancer   Vol. 135 ( 8 ) page: 1852-9   2014.10

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    DOI: 10.1002/ijc.28842

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  27. Comparison of intratumoral FDG and Cu-ATSM distributions in cancer tissue originated spheroid (CTOS) xenografts, a tumor model retaining the original tumor properties. Reviewed

    Furukawa T, Yuan Q, Jin ZH, Aung W, Yoshii Y, Hasegawa S, Endo H, Inoue M, Zhang MR, Fujibayashi Y, Saga T

    Nuclear medicine and biology   Vol. 41 ( 8 ) page: 653-9   2014.9

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    DOI: 10.1016/j.nucmedbio.2014.05.139

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  28. Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility. Reviewed

    Sogawa C, Fujiwara Y, Tsukamoto S, Ishida Y, Yoshii Y, Furukawa T, Kunieda T, Saga T

    Reproductive biology and endocrinology : RB&E   Vol. 12   page: 64   2014.7

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    DOI: 10.1186/1477-7827-12-64

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  29. PET imaging and biodistribution analysis of the effects of succinylated gelatin combined with L-lysine on renal uptake and retention of ⁶⁴Cu-cyclam-RAFT-c(-RGDfK-)₄ in vivo. Reviewed

      Vol. 86 ( 3 ) page: 478-86   2014.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejpb.2013.11.006

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  30. Controlled administration of penicillamine reduces radiation exposure in critical organs during 64Cu-ATSM internal radiotherapy: a novel strategy for liver protection. Reviewed

    Yoshii Y, Matsumoto H, Yoshimoto M, Furukawa T, Morokoshi Y, Sogawa C, Zhang MR, Wakizaka H, Yoshii H, Fujibayashi Y, Saga T

    PloS one   Vol. 9 ( 1 ) page: e86996   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0086996

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  31. Micro-positron emission tomography/contrast-enhanced computed tomography imaging of orthotopic pancreatic tumor-bearing mice using the αvβ₃ integrin tracer ⁶⁴Cu-labeled cyclam-RAFT-c(-RGDfK-)₄. Reviewed

      Vol. 12 ( 6 ) page: 376-87   2013.9

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  32. Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo. Reviewed

    Saito S, Hasegawa S, Sekita A, Bakalova R, Furukawa T, Murase K, Saga T, Aoki I

    Cancer research   Vol. 73 ( 11 ) page: 3216-24   2013.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/0008-5472.CAN-12-3837

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  33. Growth retardation and hair loss in transgenic mice overexpressing human H-ferritin gene. Reviewed

    Hasegawa S, Harada K, Morokoshi Y, Tsukamoto S, Furukawa T, Saga T

    Transgenic research   Vol. 22 ( 3 ) page: 651-8   2013.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11248-012-9669-0

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  34. C-type natriuretic peptide specifically acts on the pylorus and large intestine in mouse gastrointestinal tract. Reviewed

    Sogawa C, Wakizaka H, Aung W, Jin ZH, Tsuji AB, Furukawa T, Kunieda T, Saga T

    The American journal of pathology   Vol. 182 ( 1 ) page: 172-9   2013.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajpath.2012.09.015

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  35. Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome. Reviewed

    Yoshii Y, Furukawa T, Oyama N, Hasegawa Y, Kiyono Y, Nishii R, Waki A, Tsuji AB, Sogawa C, Wakizaka H, Fukumura T, Yoshii H, Fujibayashi Y, Lewis JS, Saga T

    PloS one   Vol. 8 ( 5 ) page: e64570   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0064570

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  36. Molecular imaging of aquaglycero-aquaporins: its potential for cancer characterization. Reviewed

    Saito Y, Furukawa T, Obata T, Saga T

    Biological & pharmaceutical bulletin   Vol. 36 ( 8 ) page: 1292-8   2013

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  37. Positron emission tomography imaging of tumor angiogenesis and monitoring of antiangiogenic efficacy using the novel tetrameric peptide probe 64Cu-cyclam-RAFT-c(-RGDfK-)4. Reviewed

    Jin ZH, Furukawa T, Claron M, Boturyn D, Coll JL, Fukumura T, Fujibayashi Y, Dumy P, Saga T

    Angiogenesis   Vol. 15 ( 4 ) page: 569-80   2012.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10456-012-9281-1

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  38. Basic studies on radioimmunotargeting of CD133-positive HCT116 cancer stem cells. Reviewed

    Jin ZH, Sogawa C, Furukawa T, Saito Y, Aung W, Fujibayashi Y, Saga T

    Molecular imaging   Vol. 11 ( 6 ) page: 445-50   2012.11

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  39. H-ferritin overexpression promotes radiation-induced leukemia/lymphoma in mice. Reviewed

    Hasegawa S, Morokoshi Y, Kanda H, Tsukamoto S, Zheng J, Tsuji AB, Furukawa T, Kakinuma S, Shimada Y, Saga T

    Carcinogenesis   Vol. 33 ( 11 ) page: 2269-75   2012.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/carcin/bgs251

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  40. Monoclonal antibody RM2 as a potential ligand for a new immunotracer for prostate cancer imaging. Reviewed

    Hasegawa Y, Oyama N, Nagase K, Fujibayashi Y, Furukawa T, Murayama Y, Arai Y, Saito S, Welch MJ, Yokoyama O

    Nuclear medicine and biology   Vol. 39 ( 7 ) page: 944-7   2012.10

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    DOI: 10.1016/j.nucmedbio.2012.05.008

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  41. Novel human monoclonal antibody against epidermal growth factor receptor as an imaging probe for hepatocellular carcinoma. Reviewed

    Sogawa C, Tsuji AB, Yoshida C, Inubushi M, Furukawa T, Koizumi M, Akahori Y, Ukai Y, Kurosawa G, Kurosawa Y, Saga T

    Nuclear medicine communications   Vol. 33 ( 7 ) page: 719-25   2012.7

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    DOI: 10.1097/MNM.0b013e3283531d68

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  42. Radiolabeled Cu-ATSM as a novel indicator of overreduced intracellular state due to mitochondrial dysfunction: studies with mitochondrial DNA-less ρ0 cells and cybrids carrying MELAS mitochondrial DNA mutation. Reviewed

      Vol. 39 ( 2 ) page: 177-85   2012.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.nucmedbio.2011.08.008

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  43. Photo-excitation of carotenoids causes cytotoxicity via singlet oxygen production. Reviewed

    Yoshii H, Yoshii Y, Asai T, Furukawa T, Takaichi S, Fujibayashi Y

    Biochemical and biophysical research communications   Vol. 417 ( 1 ) page: 640-5   2012.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2011.12.024

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  44. The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation. Reviewed

    Yoshii Y, Waki A, Yoshida K, Kakezuka A, Kobayashi M, Namiki H, Kuroda Y, Kiyono Y, Yoshii H, Furukawa T, Asai T, Okazawa H, Gelovani JG, Fujibayashi Y

    Biomaterials   Vol. 32 ( 26 ) page: 6052-8   2011.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biomaterials.2011.04.076

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  45. Molecular imaging of mesothelioma by detection of manganese-superoxide dismutase activity using manganese-enhanced magnetic resonance imaging. Reviewed

    Hasegawa S, Koshikawa-Yano M, Saito S, Morokoshi Y, Furukawa T, Aoki I, Saga T

    International journal of cancer   Vol. 128 ( 9 ) page: 2138-46   2011.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ijc.25547

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  46. Anticancer effect of dihydroartemisinin (DHA) in a pancreatic tumor model evaluated by conventional methods and optical imaging. Reviewed

    Aung W, Sogawa C, Furukawa T, Saga T

    Anticancer research   Vol. 31 ( 5 ) page: 1549-58   2011.5

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  47. Noninvasive visualization and quantification of tumor αVβ3 integrin expression using a novel positron emission tomography probe, 64Cu-cyclam-RAFT-c(-RGDfK-)4. Reviewed

      Vol. 38 ( 4 ) page: 529-40   2011.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.nucmedbio.2010.11.008

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  48. Target genes of the largest human SWI/SNF complex subunit control cell growth. Reviewed

    Inoue H, Giannakopoulos S, Parkhurst CN, Matsumura T, Kono EA, Furukawa T, Tanese N

    The Biochemical journal   Vol. 434 ( 1 ) page: 83-92   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1042/BJ20101358

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  49. Internal radiotherapy with copper-64-diacetyl-bis (N4-methylthiosemicarbazone) reduces CD133+ highly tumorigenic cells and metastatic ability of mouse colon carcinoma. Reviewed

    Yoshii Y, Furukawa T, Kiyono Y, Watanabe R, Mori T, Yoshii H, Asai T, Okazawa H, Welch MJ, Fujibayashi Y

    Nuclear medicine and biology   Vol. 38 ( 2 ) page: 151-7   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.nucmedbio.2010.08.009

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  50. Evaluation of ferritin-overexpressing brain in newly developed transgenic mice. Reviewed

    Hasegawa S, Saito S, Takanashi J, Morokoshi Y, Furukawa T, Saga T, Aoki I

    Magnetic resonance imaging   Vol. 29 ( 2 ) page: 179-84   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.mri.2010.08.013

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  51. Tumor enhancement effect of overexpressed manganese-superoxide dismutase in manganese-enhanced MR imaging. Reviewed

    Hasegawa S, Saito S, Koshikawa-Yano M, Furukawa T, Aoki I, Saga T

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 10 ( 3 ) page: 155-8   2011

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  52. RGD-cyclam conjugate: synthesis and potential application for positron emission tomography. Reviewed

    Galibert M, Jin ZH, Furukawa T, Fukumura T, Saga T, Fujibayashi Y, Dumy P, Boturyn D

    Bioorganic & medicinal chemistry letters   Vol. 20 ( 18 ) page: 5422-5   2010.9

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    DOI: 10.1016/j.bmcl.2010.07.114

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  53. Fusion protein based on Grb2-SH2 domain for cancer therapy. Reviewed

    Saito Y, Furukawa T, Arano Y, Fujibayashi Y, Saga T

    Biochemical and biophysical research communications   Vol. 399 ( 2 ) page: 262-7   2010.8

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    DOI: 10.1016/j.bbrc.2010.07.066

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  54. Basic study on SH2 domain of Grb2 as a molecular probe for detection of RTK activation. Reviewed

    Saito Y, Furukawa T, Arano Y, Fujibayashi Y, Saga T

    International journal of oncology   Vol. 37 ( 2 ) page: 281-7   2010.8

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  55. Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+ highly tumorigenic cells in mouse colon carcinoma. Reviewed

    Yoshii Y, Furukawa T, Kiyono Y, Watanabe R, Waki A, Mori T, Yoshii H, Oh M, Asai T, Okazawa H, Welch MJ, Fujibayashi Y

    Nuclear medicine and biology   Vol. 37 ( 4 ) page: 395-404   2010.5

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    DOI: 10.1016/j.nucmedbio.2009.12.011

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  56. Effect of multimerization of a linear Arg-Gly-Asp peptide on integrin binding affinity and specificity. Reviewed

    Jin ZH, Furukawa T, Waki A, Akaji K, Coll JL, Saga T, Fujibayashi Y

    Biological & pharmaceutical bulletin   Vol. 33 ( 3 ) page: 370-8   2010

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  57. Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase: implications for the mechanism of acetate PET. Reviewed

    Yoshii Y, Waki A, Furukawa T, Kiyono Y, Mori T, Yoshii H, Kudo T, Okazawa H, Welch MJ, Fujibayashi Y

    Nuclear medicine and biology   Vol. 36 ( 7 ) page: 771-7   2009.10

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    DOI: 10.1016/j.nucmedbio.2009.05.006

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  58. A medaka model of cancer allowing direct observation of transplanted tumor cells in vivo at a cellular-level resolution. Reviewed

    Hasegawa S, Maruyama K, Takenaka H, Furukawa T, Saga T

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 106 ( 33 ) page: 13832-7   2009.8

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    DOI: 10.1073/pnas.0903999106

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  59. Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism. Reviewed

    Yoshii Y, Furukawa T, Yoshii H, Mori T, Kiyono Y, Waki A, Kobayashi M, Tsujikawa T, Kudo T, Okazawa H, Yonekura Y, Fujibayashi Y

    Cancer science   Vol. 100 ( 5 ) page: 821-7   2009.5

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  60. Comparison of conventional and novel PET tracers for imaging mesothelioma in nude mice with subcutaneous and intrapleural xenografts. Reviewed

    Tsuji AB, Sogawa C, Sugyo A, Sudo H, Toyohara J, Koizumi M, Abe M, Hino O, Harada YN, Furukawa T, Suzuki K, Saga T

    Nuclear medicine and biology   Vol. 36 ( 4 ) page: 379-88   2009.5

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    DOI: 10.1016/j.nucmedbio.2009.01.018

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  61. Radio-copper-labeled Cu-ATSM: an indicator of quiescent but clonogenic cells under mild hypoxia in a Lewis lung carcinoma model. Reviewed

    Oh M, Tanaka T, Kobayashi M, Furukawa T, Mori T, Kudo T, Fujieda S, Fujibayashi Y

    Nuclear medicine and biology   Vol. 36 ( 4 ) page: 419-26   2009.5

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    DOI: 10.1016/j.nucmedbio.2009.01.016

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  62. Preparation and evaluation of ethyl [(18)F]fluoroacetate as a proradiotracer of [(18)F]fluoroacetate for the measurement of glial metabolism by PET. Reviewed

    Mori T, Sun LQ, Kobayashi M, Kiyono Y, Okazawa H, Furukawa T, Kawashima H, Welch MJ, Fujibayashi Y

    Nuclear medicine and biology   Vol. 36 ( 2 ) page: 155-62   2009.2

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    DOI: 10.1016/j.nucmedbio.2008.11.006

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  63. Comparison of semiquantitative fluorescence imaging and PET tracer uptake in mesothelioma models as a monitoring system for growth and therapeutic effects. Reviewed

    Saito Y, Furukawa T, Arano Y, Fujibayashi Y, Saga T

    Nuclear medicine and biology   Vol. 35 ( 8 ) page: 851-60   2008.11

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    DOI: 10.1016/j.nucmedbio.2008.08.002

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  64. Basic evaluation of FES-hERL PET tracer-reporter gene system for in vivo monitoring of adenoviral-mediated gene therapy. Reviewed

    Lohith TG, Furukawa T, Mori T, Kobayashi M, Fujibayashi Y

    Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging   Vol. 10 ( 5 ) page: 245-52   2008.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11307-008-0149-0

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  65. Alterations in manganese, copper, and zinc contents, and intracellular status of the metal-containing superoxide dismutase in human mesothelioma cells. Reviewed

    Hasegawa S, Koshikawa M, Takahashi I, Hachiya M, Furukawa T, Akashi M, Yoshida S, Saga T

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)   Vol. 22 ( 3 ) page: 248-55   2008

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    DOI: 10.1016/j.jtemb.2008.05.001

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  66. Potential role of ferritin heavy chain in oxidative stress and apoptosis in human mesothelial and mesothelioma cells: implications for asbestos-induced oncogenesis. Reviewed

    Aung W, Hasegawa S, Furukawa T, Saga T

    Carcinogenesis   Vol. 28 ( 9 ) page: 2047-52   2007.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/carcin/bgm090

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  67. Interleukin 6 induces the hair follicle growth phase (anagen). Reviewed

    Tanabe A, Ogawa Y, Takemoto T, Wang Y, Furukawa T, Kono H, Adachi Y, Kusumoto K

    Journal of dermatological science   Vol. 43 ( 3 ) page: 210-3   2006.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jdermsci.2006.04.004

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  68. Double-tracer autoradiography with Cu-ATSM/FDG and immunohistochemical interpretation in four different mouse implanted tumor models. Reviewed

    Tanaka T, Furukawa T, Fujieda S, Kasamatsu S, Yonekura Y, Fujibayashi Y

    Nuclear medicine and biology   Vol. 33 ( 6 ) page: 743-50   2006.8

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    DOI: 10.1016/j.nucmedbio.2006.05.005

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  69. New approach to fully automated synthesis of sodium [18F]fluoroacetate -- a simple and fast method using a commercial synthesizer. Reviewed

    Sun LQ, Mori T, Dence CS, Ponde DE, Welch MJ, Furukawa T, Yonekura Y, Fujibayashi Y

    Nuclear medicine and biology   Vol. 33 ( 1 ) page: 153-8   2006.1

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    DOI: 10.1016/j.nucmedbio.2005.07.005

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  70. Acquisition of resistance to antitumor alkylating agent ACNU: a possible target of positron emission tomography monitoring. Reviewed

    Kawai H, Toyohara J, Kado H, Nakagawa T, Takamatsu S, Furukawa T, Yonekura Y, Kubota T, Fujibayashi Y

    Nuclear medicine and biology   Vol. 33 ( 1 ) page: 29-35   2006.1

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    DOI: 10.1016/j.nucmedbio.2005.10.002

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  71. Potential of the FES-hERL PET reporter gene system -- basic evaluation for gene therapy monitoring. Reviewed

    Furukawa T, Lohith TG, Takamatsu S, Mori T, Tanaka T, Fujibayashi Y

    Nuclear medicine and biology   Vol. 33 ( 1 ) page: 145-51   2006.1

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    DOI: 10.1016/j.nucmedbio.2005.07.013

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  72. Noninvasive imaging of transplanted living functional cells transfected with a reporter estrogen receptor gene. Reviewed

    Takamatsu S, Furukawa T, Mori T, Yonekura Y, Fujibayashi Y

    Nuclear medicine and biology   Vol. 32 ( 8 ) page: 821-9   2005.11

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    DOI: 10.1016/j.nucmedbio.2005.06.010

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  73. Basic characterization of 64Cu-ATSM as a radiotherapy agent. Reviewed

    Obata A, Kasamatsu S, Lewis JS, Furukawa T, Takamatsu S, Toyohara J, Asai T, Welch MJ, Adams SG, Saji H, Yonekura Y, Fujibayashi Y

    Nuclear medicine and biology   Vol. 32 ( 1 ) page: 21-8   2005.1

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    DOI: 10.1016/j.nucmedbio.2004.08.012

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  74. Radiolabeled choline as a proliferation marker: comparison with radiolabeled acetate. Reviewed

    Yoshimoto M, Waki A, Obata A, Furukawa T, Yonekura Y, Fujibayashi Y

    Nuclear medicine and biology   Vol. 31 ( 7 ) page: 859-65   2004.10

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    DOI: 10.1016/j.nucmedbio.2004.05.002

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  75. Intra-tumoral distribution of (64)Cu-ATSM: a comparison study with FDG. Reviewed

    Obata A, Yoshimoto M, Kasamatsu S, Naiki H, Takamatsu S, Kashikura K, Furukawa T, Lewis JS, Welch MJ, Saji H, Yonekura Y, Fujibayashi Y

    Nuclear medicine and biology   Vol. 30 ( 5 ) page: 529-34   2003.7

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  76. Involvement of ABC7 in the biosynthesis of heme in erythroid cells: interaction of ABC7 with ferrochelatase. Reviewed

    Taketani S, Kakimoto K, Ueta H, Masaki R, Furukawa T

    Blood   Vol. 101 ( 8 ) page: 3274-80   2003.4

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    DOI: 10.1182/blood-2002-04-1212

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  77. Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors. Reviewed

    Inoue H, Furukawa T, Giannakopoulos S, Zhou S, King DS, Tanese N

    The Journal of biological chemistry   Vol. 277 ( 44 ) page: 41674-85   2002.11

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    DOI: 10.1074/jbc.M205961200

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  78. A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis. Reviewed

    Mizutani A, Furukawa T, Adachi Y, Ikehara S, Taketani S

    The Journal of biological chemistry   Vol. 277 ( 18 ) page: 15851-8   2002.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M111431200

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MISC 5

  1. Cu-64-ATSM internal radiotherapy to treat colon cancer acquiring resistance to antiangiogenic therapy with bevacizumab Reviewed

    Yoshii Yukie, Furukawa Takako, Yoshimoto Mitsuyoshi, Matsumoto Hiroki, Zhang Ming-Rong, Inubushi Masayuki, Fujibayashi Yasuhisa, Saga Tsuneo

    JOURNAL OF NUCLEAR MEDICINE   Vol. 57   page: .   2016.5

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    Web of Science

  2. Development of the Fibronectin Mimetic Peptide KSSPHSRN(SG)(5)RGDSP as a Novel Radioprobe for Molecular Imaging of the Cancer Biomarker alpha(5)beta(1) Integrin Reviewed

    Jin Zhao-Hui, Furukawa Takako, Kumata Katsushi, Xie Lin, Yui Joji, Wakizaka Hidekatsu, Fujibayashi Yasuhisa, Zhang Ming-Rong, Saga Tsuneo

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   Vol. 38 ( 11 ) page: 1722-1731   2015.11

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  3. Development of drug screening system with nanoimprinting 3D culture to provide effective drugs in vivo and the accompanying PET probes for therapy monitoring Reviewed

    Yoshii Yukie, Furukawa Takako, Waki Atsuo, Itoh Manabu, Zhang Ming-Rong, Wakizaka Hidekatsu, Kiyono Yasushi, Fujibayashi Yasuhisa, Saga Tsuneo

    JOURNAL OF NUCLEAR MEDICINE   Vol. 56 ( 3 ) page: .   2015.5

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  4. Sensitized Cu-64-ATSM internal radiotherapy targeting tumor malignant regions: approach based on its biological characteristics Reviewed

    Yoshii Yukie, Furukawa Takako, Matsumoto Hiroki, Yoshimoto Mitsuyoshi, Kiyono Yasushi, Zhang Ming-Rong, Fujibayashi Yasuhisa, Saga Tsuneo

    JOURNAL OF NUCLEAR MEDICINE   Vol. 56 ( 3 ) page: .   2015.5

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  5. Microarray analysis of human breast cancer cells treated with In-111-trastuzumab modified with nuclear localizing signal peptides Reviewed

    Hasegawa Sumitaka, Li Huizi, Morokoshi Yukie, Furukawa Takako, Saga Tsuneo

    JOURNAL OF NUCLEAR MEDICINE   Vol. 56 ( 3 ) page: .   2015.5

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KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. PETイメージング剤CuATSMの腫瘍集積とNADの代謝・酸化還元バランス

    Grant number:21K07670  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    古川 高子, 清野 泰

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    Authorship:Principal investigator 

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    放射性標識CuATSMは固形がんに集積し、PET診断や標的RI治療への利用が期待され、臨床研究において、CuATSM集積と予後に相関が報告されているが、CuATSMの集積が予後不良につながる理由は十分解明されていない。本研究では、これまでにCuATSMの細胞集積と治療抵抗性獲得を結ぶ可能性が示された細胞質NAD+/NADHや遺伝子発現調節因子CtBPの他に、より広範に働く機序として、NADの調節を受けるタンパク質やNADの生合成・分解に係る酵素の関与について、培養細胞や動物を用いてCuATSMの集積が予後不良につながる機序の解明を進め、CuATSM高集積がんの効果的な治療法の提案につなげる。

  2. 生体内代謝物解析のためのレーザー分光に基づく放射性炭素同位体分析法の開発

    Grant number:18H03469  2018.4 - 2021.3

    富田 英生

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  3. Does aquisition of hypoxia tolerance and stemness by cancer cells affect the accumulation of a hypoxia imaging agent.

    Grant number:18K07672  2018.4 - 2021.3

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  4. Cellular accumulation of Cu-ATSM and NADH/NAD+ ratio in cytosol

    Grant number:15K09911  2015.4 - 2019.3

    Furukawa Takako

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    Cu-ATSM labeled with positron emitting radioisotopes is supposed to accumulate into hypoxic tissues and expected to play a critical role in detecting hypoxic cancer and help to predict prognosis and select therapy strategy. The relation between cancer hypoxia and Cu-ATSM accumulation is, however, still ambiguous, hindering the interpretation of Cu-ATSM accumulation and its utilization. In this study, we established cell lines stably expressing newly developed Peredox protein which can report cytoplasmic NADH/NAD+ ratio as green/red fluorescence ratio, and demonstrated that cellular accumulation of Cu-ATSM depends on the cytoplasmic NADH/NAD+ ratio which reflects the redox status of cancer cell cytoplasm and the presence of hypoxia.

  5. Cu-ATSMの集積と細胞質NADH/NDA比

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  6. PETによる固形がんの代謝特性解明:効果的診断法確立に向けての基礎研究

    2012.4 - 2014.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 5

  1. 放射線管理学実験

    2018

  2. 放射線計測学Ⅱ

    2018

  3. 放射化学実験

    2018

  4. 放射線管理学

    2018

  5. 放射化学・放射線化学及び演習

    2018