Updated on 2021/03/23

写真a

 
MIYASAKA Yuki
 
Organization
Graduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering Division for Research of Laboratory Animals Assistant Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Assistant Professor

Degree 1

  1. 博士(医学) ( 2016.3   新潟大学 ) 

Research Interests 3

  1. マウス

  2. マウス遺伝学

  3. CRISPR/Cas9システム

Research Areas 3

  1. Life Science / Laboratory animal science

  2. Life Science / Genetics

  3. Life Science / Parasitology  / マラリア

Current Research Project and SDGs 1

  1. マウスを用いた疾患感受性遺伝子の解析

Research History 1

  1. 独立行政法人日本学術振興会特別研究員DC2

    2014.4 - 2016.3

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    Country:Japan

Education 3

  1. Niigata University

    2012.4 - 2016.3

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    Country: Japan

  2. Niigata University

    2010.4 - 2012.3

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    Country: Japan

  3. Tokyo University of Agriculture

    2006.4 - 2010.3

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    Country: Japan

Professional Memberships 4

  1. 日本実験動物学会

  2. 日本寄生虫学会

  3. 日本糖尿病・肥満動物学会

  4. 日本ゲノム編集学会

 

Papers 17

  1. Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition, and Implication of CDH23 in Schizophrenia. Reviewed

    Balan S, Ohnishi T, Watanabe A, Ohba H, Iwayama Y, Toyoshima M, Hara T, Hisano Y, Miyasaka Y, Toyota T, Shimamoto-Mitsuyama C, Maekawa M, Numata S, Ohmori T, Shimogori T, Kikkawa Y, Hayashi T, Yoshikawa T.

    Schizophr. Bull.     page: sbab007   2021

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    Language:English   Publishing type:Research paper (scientific journal)  

  2. SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation. Reviewed

    Takeichi T, Hirabayashi T, Miyasaka Y, Kawamoto A, Okuno Y, Taguchi S, Tanahashi K, Murase C, Takama H, Tanaka K, Boeglin WE, Calcutt MW, Watanabe D, Kono M, Muro Y, Ishikawa J, Ohno T, Brash AR, Akiyama M.

    J. Clin. Invest.   Vol. 130 ( 2 ) page: 890 - 903   2020

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    Language:English   Publishing type:Research paper (scientific journal)  

  3. Ablation of Iah1, a candidate gene for diet-induced fatty liver, does not affect liver lipid accumulation in mice. Reviewed

    Masuya T, Suzuki M, Tsujimura J, Kanamori S, Miyasaka Y, Ohno T, Murai A, Horio F, Kobayashi M.

    PLoS One.   Vol. 15 ( 5 ) page: e0233087   2020

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    Language:English   Publishing type:Research paper (scientific journal)  

  4. c.753A>G genome editing of a Cdh23 ahl allele delays age-related hearing loss and degeneration of cochlear hair cells in C57BL/6J mice. Reviewed

    Yasuda SP, Seki Y, Suzuki S, Ohshiba Y, Hou X, Matsuoka K, Wada K, Shitara H, Miyasaka Y, Kikkawa Y.

    Hear. Res.   Vol. 389   page: 107926   2020

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    Language:English   Publishing type:Research paper (scientific journal)  

  5. Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research. Reviewed

    Ohno T, Miyasaka Y, Kuga M, Ushida K, Matsushima M, Kawabe T, Kikkawa Y, Mizuno M, Takahashi M

    Exp. Anim.   Vol. 68 ( 3 ) page: 243 - 255   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

  6. OHC-TRECK: A Novel System Using a Mouse Model for Investigation of the Molecular Mechanisms Associated with Outer Hair Cell Death in the Inner Ear. Reviewed

    Matsuoka K, Wada K, Miyasaka Y, Yasuda SP, Seki Y, Nishito Y, Yonekawa H, Taya C, Shitara H, Kikkawa Y.

    Sci. Rep.   Vol. 9 ( 1 ) page: 5285   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

  7. Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta. Reviewed

    Ohno T, Kai T, Miyasaka Y, Maruyama H, Ishih A, Kino H.

    Parasitol. Int.   Vol. 67 ( 4 ) page: 357-361   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

  8. Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11. Reviewed

    Maegawa T, Miyasaka Y, Kobayashi M, Babaya N, Ikegami H, Horio F, Takahashi M, Ohno T.

    Mamm. Genome   Vol. 29 ( 3-4 ) page: 273 - 280   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

  9. A new missense mutation in the paired domain of the mouse Pax3 gene. Reviewed

    Ohno T, Maegawa T, Katoh H, Miyasaka Y, Suzuki M, Kobayashi M, Horio F.

    Exp. Anim.   Vol. 66 ( 3 ) page: 245-250   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

  10. A novel splice site mutation of myosin VI in mice leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells. Reviewed

    Seki Y, Miyasaka Y, Suzuki S, Wada K, Yasuda SP, Matsuoka K, Ohshiba Y, Endo K, Ishii R, Shitara H, Kitajiri SI, Nakagata N, Takebayashi H, Kikkawa Y.

    PLoS One   Vol. 12 ( 8 ) page: e0183477   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

  11. Heterozygous mutation of Ush1g/Sans in mice causes early-onset progressive hearing loss, which is recovered by reconstituting the strain-specific mutation in Cdh23. Reviewed

    Miyasaka Y, Shitara H, Suzuki S, Yoshimoto S, Seki Y, Ohshiba Y, Okumura K, Taya C, Tokano H, Kitamura K, Takada T, Hibino H, Shiroishi T, Kominami R, Hiromichi Y, Kikkawa Y.

    Hum. Mol. Genet.   Vol. 25 ( 10 ) page: 2045-2059   2016

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  12. Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice. Reviewed

    Suzuki S, Ishikawa M, Ueda T, Ohshiba Y, Miyasaka Y, Okumura K, Yokohama M, Taya C, Matsuoka K, Kikkawa Y.

    Exp. Anim.   Vol. 64 ( 3 ) page: 241-251   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

  13. Dilation of the inferior colliculus and hypersensitivity to sound in Wnt1-cre and Wnt1-GAL4 double-transgenic mice. Reviewed

    Nakajima M, Nishikawa C, Miyasaka Y, Kikkawa Y, Mori H, Tsuruta M, Okuyama S, Furukawa Y.

      Vol. 566   page: 236-240   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

  14. Compound Heterozygosity of the Functionally Null Cdh23v-ngt and Hypomorphic Cdh23ahl Alleles Leads to Early-onset Progressive Hearing Loss in Mice. Reviewed

    Miyasaka Y, Suzuki S, Ohshiba Y, Watanabe K, Sagara Y, Yasuda SP, Matsuoka K, Shitara H, Yonekawa H, Kominami R, Kikkawa Y.

    Exp. Anim.   Vol. 62 ( 4 ) page: 333-346   2013

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  15. Advantages of a mouse model for human hearing impairment. Reviewed

    Kikkawa Y, Seki Y, Okumura K, Ohshiba Y, Miyasaka Y, Suzuki S, Ozaki M, Matsuoka K, Noguchi Y, Yonekawa H.

    Exp. Anim.   Vol. 61   page: 85-98   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

  16. Independent genetic control of early and late stages of chemically induced skin tumors in a cross of a Japanese wild-derived inbred mouse strain, MSM/Ms. Reviewed

    Okumura K, Sato M, Saito M, Miura I, Wakana S, Mao JH, Miyasaka Y, Kominami R, Wakabayashi Y.

    Carcinogenesis   Vol. 33   page: 2260-2268   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

  17. Bcl11b heterozygosity leads to age-related hearing loss and degeneration of outer hair cells of the mouse cochlea. Reviewed

    Okumura H, Miyasaka Y, Morita Y, Nomura T, Mishima Y, Takahashi S, Kominami R.

    Exp. Anim.   Vol. 60   page: 355-361   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

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Books 2

  1. Effects of Genetic Background on Susceptibility and the Acceleration of Hearing Loss in Mice.

    Yasuda SP, Miyasaka Y, Kikkawa Y( Role: Joint author)

    InTech  2018 

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    Language:English

  2. Genetic modifiers of hearing loss in mice: The case of phenotypic modification in homozygous Cdh23ahl age-related hearing loss.

    Kikkawa Y, Miyasaka Y( Role: Joint author)

    Karger Publishers, Basel, Switzerland  2016 

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    Language:English

Presentations 2

  1. マウスの遺伝的背景に潜む聴覚表現型を修飾する1塩基置換

    宮坂勇輝,設楽浩志,鈴木沙理,高田豊行,城石俊彦,木南 凌,米川博通,吉川欣亮

    日本遺伝学会第88回大会 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:三島市   Country:Japan  

  2. マウス加齢性難聴発症のcomplex traits

    宮坂勇輝

    平成24年度国立遺伝学研究所研究会 マウスForward Geneticsの新潮流 -Common diseases (complex traits) のマウス遺伝学- 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

Research Project for Joint Research, Competitive Funding, etc. 3

  1. ゲノム編集技術を用いた長鎖配列ノックインマウスの作製支援システムの構築

    2018.9 - 2019.3

    一般財団法人共済団医学研究奨励助成金 

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    Grant type:Competitive

  2. ゲノム編集技術を用いたアレルギー疾患感受性モデルマウスの原因遺伝子の同定

    2017.4 - 2018.3

    日比野基金医学研究助成 

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    Grant type:Competitive

  3. ゲノム編集技術を用いた新規マウス致死遺伝子の同定とその機能解析

    2016.4 - 2018.12

    日東学術振興財団研究助成金 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. マウスNC系統の特性を利用した脳マラリア発症に必須な遺伝的要因の特定

    Grant number:20K15698  2020.4 - 2024.3

    科学研究費補助金   若手研究

  2. ゲノム編集技術を用いたマウスのストレプトゾトシン感受性遺伝子の同定と機能解析

    Grant number:17K14975  2017.4 - 2019.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  3. 亜種間コンソミック系統を基盤とした新規難聴モデルマウスの樹立

    Grant number:14J06119  2014.4 - 2016.3

    科学研究費補助金  特別研究員奨励費

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    Authorship:Principal investigator