2023/04/22 更新

写真a

ニシホリ マサヒロ
西堀 正洋
NISHIHORI Masahiro
所属
医学部附属病院 脳神経外科 病院助教
職名
病院助教
連絡先
メールアドレス
外部リンク

学位 1

  1. 医学博士 ( 2021年9月   名古屋大学 ) 

研究キーワード 12

  1. 脳動脈瘤

  2. 硬膜動静脈瘻

  3. 医用画像処理

  4. 脳血管内治療

  5. 頸動脈狭窄

  6. 脳血管内治療

  7. 脳卒中の外科

  8. 脳卒中

  9. 脳動静脈奇形

  10. 脳動脈瘤

  11. 硬膜動静脈瘻

  12. 機械的血栓回収療法

研究分野 2

  1. ライフサイエンス / 脳神経外科学

  2. ライフサイエンス / 脳神経外科学

経歴 2

  1. 名古屋大学   医学部附属病院 脳神経外科   病院助教

    2016年3月 - 現在

  2. 名古屋大学   医学部附属病院 脳神経外科   病院助教

    2016年3月 - 現在

学歴 2

  1. 名古屋大学   医学系研究科博士課程   総合医学専攻

    2013年4月 - 2016年2月

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    国名: 日本国

  2. 名古屋大学   医学部   医学科

    2002年4月 - 2008年3月

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    国名: 日本国

所属学協会 12

  1. 日本脳神経外科学会

  2. 日本脳神経血管内治療学会

  3. 日本脳卒中学会

  4. 日本脳卒中の外科学会

  5. 日本脳神経CI学会

  6. 日本脳神経外科コングレス

  7. 日本脳神経血管内治療学会

  8. 日本脳神経外科学会

  9. 日本脳神経外科コングレス

  10. 日本脳神経CI学会

  11. 日本脳卒中学会

  12. 日本脳卒中の外科学会

▼全件表示

委員歴 7

  1. 第48回日本脳卒中学会学術集会   プログラム委員  

    2022年4月 - 現在   

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    団体区分:学協会

  2. 第38回NPO法人日本脳神経血管内治療学会学術集会   プログラム委員  

    2022年1月 - 2022年11月   

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    団体区分:学協会

  3. 日本脳神経血管内治療学会 中部地方会   事務局長  

    2021年12月 - 現在   

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    団体区分:学協会

  4. 第47回日本脳卒中学会学術集会   プログラム委員  

    2021年2月 - 2022年1月   

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    団体区分:学協会

  5. 第46回日本脳卒中学会学術集会   査読委員  

    2020年10月 - 2021年2月   

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    団体区分:学協会

  6. 日本脳卒中学会   評議員  

    2020年8月 - 2022年7月   

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    団体区分:学協会

  7. 日本脳神経外科学会 第76回総会   プログラム委員  

    2016年10月 - 2017年10月   

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    団体区分:学協会

▼全件表示

 

論文 71

  1. Rare Dilated Collateral Circulation from Accessory Meningeal Artery to Inferolateral Trunk: A Case Report

    IKEZAWA Mizuka, MAEDA Kenko, TAKASU Syuntaro, TAKEMOTO Masaya, NISHIHORI Masahiro, CHOO Jungsu, SAGO Fumihiro, SOMIYA Daiki, DOBA Kohei, IKEDA Akira

    NMC Case Report Journal   10 巻 ( 0 ) 頁: 47 - 50   2023年12月

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    記述言語:英語   出版者・発行元:The Japan Neurosurgical Society  

    <p>The accessory meningeal artery (AMA) demonstrates various potential anastomoses with the external (ECA) and internal (ICA) carotid arteries. However, rarely does the AMA markedly dilate and compensate for ICA blood flow. A 52-year-old woman with nonspecific symptoms was diagnosed with multiple cerebral aneurysms and abnormal blood vessels observed on magnetic resonance angiography. Digital subtraction angiography revealed four aneurysms and anastomoses between the left AMA and inferolateral trunk (ILT). In addition, two sequential severe flexions were observed in the cervical portion of the left ICA. No ischemic lesions were detected on magnetic resonance imaging. In conclusion, we experienced a rare case in which the AMA-ILT anastomosis was highly developed. This case also presented with the unusual characteristics of an anomaly in the extracranial ICA and multiple aneurysms.</p>

    DOI: 10.2176/jns-nmc.2022-0308

    CiNii Research

  2. Butterfly needle tap and suction (BTS) technique: a treatment for recurrent chronic subdural hematoma after burr hole craniostomy

    Yamamoto Shun, Nagashima Yoshitaka, Maki Hideki, Nishimura Yusuke, Araki Yoshio, Nishihori Masahiro, Noda Tomoyuki, Imai Tasuku, Kawabata Teppei, Ueno Masahiro, Nishida Yasumasa, Saito Ryuta

    ACTA NEUROCHIRURGICA   165 巻 ( 4 ) 頁: 841 - 848   2023年4月

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    記述言語:英語   出版者・発行元:Acta Neurochirurgica  

    Background: In this study, we propose a butterfly needle tap and suction (BTS) technique for recurrent chronic subdural hematoma (CSDH) as an alternative to reoperation with burr hole craniostomy (BHC) and investigate its efficacy and safety. The procedure involves percutaneous puncture through the burr hole created during the previous surgery and subsequent hematoma evacuation using a butterfly needle. Methods: This retrospective study included patients who underwent BTS for CSDH at Ogaki Municipal Hospital between January 2017 and December 2020. The follow-up CT scans were reviewed after several weeks. We evaluated the number of percutaneous punctures required to resolve CSDH during the BTS technique, the volume of the evacuated hematoma, and procedure-related complications. Results: Twenty-six patients were enrolled in the study, 21 of whom achieved resolution of the hematoma using punctures with the BTS technique alone (mean, 2.2 ± 1.5). Five patients had a recurrence of hematoma after one or more punctures during the BTS technique, and they underwent reoperation with BHC according to the surgeon’s decision or patient requests. Among the 55 punctures, 43.0 ± 16.0 ml of hematoma was evacuated per puncture. The evacuated hematoma volume was 41.9 ± 16.4 ml in the BTS-alone group and 49.4 ± 12.9 ml in the reoperation group, with no significant difference (p = 0.25). Three patients complained of a headache during the puncture procedure, and no other complications, including intracranial hemorrhage or infection, were reported therein. Conclusions: The BTS technique is an effective alternative to reoperation with BHC.

    DOI: 10.1007/s00701-023-05543-4

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  3. Antiplatelet therapy discontinuation after stent-assisted coil embolization for intracranial aneurysms: a single-center, long-term, retrospective, observational study

    Goto S., Izumi T., Nishihori M., Imai T., Araki Y., Kanamori F., Uda K., Yokoyama K., Saito R.

    Journal of Neurosurgery   138 巻 ( 3 ) 頁: 724 - 731   2023年3月

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    出版者・発行元:Journal of Neurosurgery  

    OBJECTIVE The protocol for antiplatelet therapy after stent-assisted coil embolization (SACE) for intracranial aneurysms is not well established. In particular, the indications for single antiplatelet therapy (SAPT) discontinuation remain controversial. The authors investigated the long-term outcomes of SAPT discontinuation after SACE among patients at a single institution. METHODS Patients who underwent SACE during the period from 2010 to 2020 and who were followed up for > 1 year were included in this study. The delayed ischemic and hemorrhagic complication rates were examined during follow-up. Moreover, the risk factors of antiplatelet therapy reduction or discontinuation and the outcomes of SAPT discontinuation were examined. RESULTS In total, 240 patients were included in the analysis. The average patient age was 60.3 years, and the average follow-up period was 46.7 months. Nine (3.8%) patients presented with symptomatic delayed ischemic complication, and 3 (1.3%) patients experienced a decline in modified Rankin Scale score. The stent configuration (T- or Y-stent) was the only risk factor associated with delayed ischemic complication (p < 0.001). SAPT was discontinued in 147 (71.7%) of 205 patients who were followed up for > 2 years, and no ischemic complications were observed. CONCLUSIONS It is safe to discontinue SAPT in patients without ischemic complications and with stable intraaneurysmal signals on MRA 2 years after SACE. The T- or Y-stent is a high-risk factor for delayed ischemic complications, and antiplatelet therapy reduction or discontinuation should be cautiously considered.

    DOI: 10.3171/2022.6.JNS22815

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  4. Characteristic image on cerebral angiography in ruptured blood blister-like aneurysms

    Kato Naoki, Izumi Takashi, Nishihori Masahiro, Goto Shunsaku, Araki Yoshio, Yokoyama Kinya, Saito Ryuta

    CLINICAL NEUROLOGY AND NEUROSURGERY   225 巻   頁: 107583   2023年2月

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    記述言語:英語   出版者・発行元:Clinical Neurology and Neurosurgery  

    Objective: To evaluate the static and dynamic features of blood blister-like aneurysms (BBAs) using cerebral angiography to identify characteristic features to improve the diagnosis of these uncommon aneurysms. Methods: Digital subtraction angiography (DSA) images were compared between patients with BBAs (n = 12, group A) and patients with unruptured paraclinoid aneurysms ≤ 5 mm in size treated by endovascular procedures (n = 12, group B). DSA images were assessed for irregularities in the diameter of the parent artery and delayed inflow and outflow of contrast medium in the aneurysm. Enlargement of the aneurysm and morphological changes from the first assessment were also evaluated in patients with BBAs. Results: Compared to the group B, group A had a higher proportion of irregular vessel diameter (p = 0.013) and the delayed contrast medium outflow (p = 0.014). As well, stagnation of contrast medium along the aneurysm wall was a characteristic finding of BBAs, even for small aneurysms. Conclusion: Irregular morphological features of the parent artery and delayed contrast medium outflow as characteristic findings of ruptured BBAs may improve the diagnosis of these uncommon aneurysms, which remains challenging in practice.

    DOI: 10.1016/j.clineuro.2022.107583

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  5. Differences in gaze behaviors between trainees and experts during endovascular therapy for cerebral aneurysms: a preliminary study using a cerebral aneurysm model

    Otsuka Takafumi, Izumi Takashi, Yamamoto Masaya, Seshita Yusuke, Kohama Takeshi, Nishihori Masahiro, Tsukada Tetsuya, Saito Ryuta

    NAGOYA JOURNAL OF MEDICAL SCIENCE   85 巻 ( 1 ) 頁: 50 - 58   2023年2月

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    記述言語:英語   出版者・発行元:Nagoya Journal of Medical Science  

    In the neuroendovascular field, the training of operators has become an important issue. Recently, eye-tracking technology has been introduced into various fields of medical education. This study aimed to apply eye-tracking technology to the training of neuroendovascular therapy. Six neurosurgeons, including three neuroendovascular specialists and three trainees, at our institution and related facilities participated in the study. Eye movement was recorded by the eye-tracking device during the microcatheter navigation and coil placement into the silastic aneurysm model under biplane X-ray fluoroscopy. Eye-tracking analysis during neuroendovascular therapy was feasible in all six subjects. In microcatheter navigation, specialists tended to more frequently switch their attention between frontal and lateral images than trainees. In coil embolization, the overall gaze frequency tended to increase, and the average fixation duration tended to decrease as the number of experienced cases increased. Inexperienced operators tend to fix their gaze when they are operators than when they are assistants. More experienced operators tended to look at the microcatheter longer in the coil insertion task. The eye-tracking analysis may be useful for operator training in neuroendovascular therapy. Experts may have moved their eyes more frequently than trainees to gaze at the right place. In the future, it will be necessary to collect gaze data for more operators in various tasks.

    DOI: 10.18999/nagjms.85.1.50

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  6. The usefulness of three-dimensional fusion imaging of spinal arteriovenous malformation by a workstation connected to angiography systems

    Nagashima Yoshitaka, Izumi Takashi, Nishimura Yusuke, Nishihori Masahiro, Oyama Takahiro, Matsuo Mamoru, Ito Hiroshi, Nishii Tomoya, Saito Ryuta

    NAGOYA JOURNAL OF MEDICAL SCIENCE   85 巻 ( 1 ) 頁: 127 - 133   2023年2月

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    記述言語:英語   出版者・発行元:Nagoya Journal of Medical Science  

    Digital subtraction angiography (DSA) is the most useful technique for diagnosing spinal arteriovenous malformations (AVM). In recent years, with the improvement of imaging capabilities, the usefulness of three-dimensional (3D) imaging by fusing various modalities has been recognized. The use of 3D fusion imaging with a workstation connected to an angiography system has been reported in many cases of intracranial disease, but less frequently for spinal AVM. In this article, we describe two illustrative cases of spinal AVM in which 3D fusion imaging was useful for treatment. Although 3D fusion images using the system have the disadvantage that only a maximum of two images can be fused, it provides spinal surgeons with useful information for preoperative evaluation in a small amount of time.

    DOI: 10.18999/nagjms.85.1.127

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  7. Four-dimensional digital subtraction angiography for the vascular anatomical diagnosis of dural arteriovenous malformation: Comparison with the conventional method

    Ishikawa Kojiro, Nishihori Masahiro, Izumi Takashi, Oshima Ryosuke, Uemura Takeshi, Kanamori Fumiaki, Uda Kenji, Yokoyama Kinya, Araki Yoshio, Saito Ryuta

    INTERVENTIONAL NEURORADIOLOGY     頁: 15910199221145526   2022年12月

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    記述言語:英語   出版者・発行元:Interventional Neuroradiology  

    Background: Two-dimensional digital subtraction angiography (2D-DSA) and conventional three-dimensional digital subtraction angiography (3D-DSA) are used for the detailed analysis of dural arteriovenous fistula (DAVF). Recently, four-dimensional digital subtraction angiography (4D-DSA), a novel technology, has been attracting attention. The current study aimed to evaluate the capability of 4D-DSA in assessing anatomical angioarchitecture in DAVF. Methods: In total, 10 consecutive patients with DAVF who underwent 3D-DSA and 4D-DSA at a single institution were included in the analysis. Initially, one-slice multiplanar reconstruction (MPR) images obtained via 4D-DSA and 3D-DSA were compared to investigate the visibility of the feeding artery, fistulous point, and draining vein. Next, 4D-DSA images alone were compared and evaluated with and the MPR images of conventional 3D-DSA in terms of diagnosis of the angioarchitecture. Results: In total, six men and four women (with a mean age of 65.6 ± 10.0 years) were included in the study. The MPR image obtained via 3D-DSA had a significantly better visibility of the feeding artery and fistulous point than that acquired via 4D-DSA (p < 0.05). As for the draining vein, the score was equivalent and not significant. The diagnosis of the vascular architecture of only 4D-DSA images was nearly equivalent to that of MPR images of 3D-DSA. There were no inter-rater differences. Conclusion: The MPR images obtained via 4D-DSA may be slightly inferior to those acquired via 3D-DSA in identifying fine angioarchitecture in DAVF. However, they were comparable in terms of diagnostic accuracy.

    DOI: 10.1177/15910199221145526

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  8. Abnormal foreshortening of a Flow Re-Direction Endoluminal Device caused by in-stent thrombosis immediately after deployment br

    Otsuka Takafumi, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Goto Shunsaku, Ikezawa Mizuka, Kato Naoki, Nakano Mizuki, Uda Kenji, Yokoyama Kinya, Araki Yoshio, Saito Ryuta

    NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 4 ) 頁: 884 - 889   2022年11月

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    記述言語:英語   出版者・発行元:Nagoya Journal of Medical Science  

    Thromboembolic complications are a concern in the treatment of cerebral aneurysms using a flow diverter. In this study, we report a case of abnormal foreshortening of a Flow Re-Direction Endoluminal Device (FRED) caused by in-stent thrombosis immediately after its deployment. A 72-year-old woman had a large cavernous carotid aneurysm, which caused ptosis and diplopia. FRED deployment was planned, and dual antiplatelet therapy was initiated 2 weeks before the procedure. Under systemic heparinization, FRED was deployed with local compaction over the aneurysm orifice. Cone-beam computed tomography subsequently revealed slightly poor wall apposition at the proximal side. While the balloon catheter was prepared for angioplasty, the stent became abnormally foreshortened, the proximal side slipped into the aneurysm, and the internal carotid artery became occluded. FRED was removed using a snare wire, and recanalization was obtained. The lumen of the removed FRED was filled with thrombus. The antiplatelet therapy was changed to triple regimen, and a Pipeline Flex embolization device was placed 1 month later. At that time, no thromboembolic complications were noted. It was considered that thrombotic occlusion was followed by foreshortening of FRED on the distal side because of antegrade blood flow. Multiple factors, such as increased mesh density by locally compacted stent deployment, slightly poor wall apposition, clopidogrel resistance, and the dual-layer structure of FRED, may have been involved in thrombus formation.

    DOI: 10.18999/nagjms.84.4.884

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  9. Efficacy of comparing coil behavior and distribution using the silicone aneurysm model: difference of coil distribution in the early filling stage

    Goto Shunsaku, Izumi Takashi, Nishihori Masahiro, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Saito Ryuta

    NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 4 ) 頁: 762 - 771   2022年11月

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    記述言語:英語   出版者・発行元:Nagoya Journal of Medical Science  

    This study sought to establish an experimental aneurysm model of visualizing coil insertion using radiolucent nylon coils. Moreover, this study aimed to clarify the characteristics and differences of each coil and use them clinically as indices of coil selection. The coil insertion test was performed on the 10 mm spherical silicone aneurysm model filled to a nylon coil volume embolization ratio of 11.8%. Five types of coil were randomly tested six times, and the distribution of the coils was analyzed by fluoroscopy imaging. Indices of “Area (mm2),” “Feret’s diameter (mm),” and “Circularity” were calculated from the fluoroscopic images. Among the indices, only “Area” showed a significant difference between coils (p = 0.002). On multivariate analysis, “Area” of the ED Infini was larger than those of Target XL soft and Galaxy G3 (p = 0.018 and 0.026, respectively). Furthermore, the area of the 360 soft was larger than that of G3 (p = 0.049). Analysis of the correlation between these values and the coil configuration showed that “Area” was negatively correlated with the stock-wire diameter (r = −0.50; p = 0.004) and primary coil configuration (r = −0.65; p < 0.001). When inserting the coils in the early stage, although the difference between each coil is relatively difficult to obtain, knowledge on the proper use of the coils with differences in characteristics can help in selecting the coil most appropriate for the conditions.

    DOI: 10.18999/nagjms.84.4.762

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  10. The usefulness and safety of dexmedetomidine for postoperative sedation in pediatric patients with moyamoya disease 国際誌

    Kanamori Fumiaki, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Kurimoto Michihiro, Shiba Yoshiki, Mamiya Takashi, Takayanagi Kai, Ishii Kazuki, Nishihori Masahiro, Izumi Takashi, Okamoto Sho, Saito Ryuta

    JOURNAL OF NEUROSURGERY-PEDIATRICS   30 巻 ( 3 ) 頁: 301 - 307   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Neurosurgery: Pediatrics  

    OBJECTIVE After revascularization surgery in pediatric patients with moyamoya disease (MMD), resting and avoiding crying is important. However, this inaction is often difficult because of pain or anxiety. Dexmedetomidine (DEX), which has sedative and analgesic properties, may be useful in reducing those uncomfortable conditions; however, its common side effects include bradycardia and hypotension, which have a risk of decreasing the cerebral blood flow. The aim of this study was to investigate the efficacy and safety of using DEX for pediatric patients with MMD in the acute period after revascularization surgery. METHODS This retrospective study included pediatric patients with MMD who underwent revascularization surgery. Based on whether DEX was used for light sedation during postoperative days (PODs) 0–1 after extubation, the patients were divided into DEX or control groups. For neurological outcomes, the incidence of symptomatic cerebral infarction and transient neurological events (TNEs) during PODs 0–1 and the entire hospitalization were investigated. In addition, the Richmond Agitation-Sedation Scale (RASS) was used to assess the effect of DEX, and bradycardia and hypotension were evaluated as side effects. RESULTS A total of 84 surgical procedures were included in this study (27 in the DEX group and 57 in the control group). During PODs 0–1, symptomatic infarction was not observed in either group. The incidence of TNEs was almost the same in both groups: 2 (7.4%) of the 27 procedures in the DEX group and 4 (7.0%) of the 57 procedures in the control group (p > 0.99). Moreover, the incidences of symptomatic infarction and TNEs during the entire hospitalization did not differ significantly (symptomatic infarction, p > 0.99; TNEs, p = 0.20). Regarding the DEX effect, the median RASS scores during PODs 0–1 were −1.0 (drowsy) in the DEX group and +1.0 (restless) in the control group, showing a significant difference (p < 0.01). Regarding side effects, bradycardia was observed only in 3 (11.1%) of the 27 procedures in the DEX group (p = 0.03), and hypotension was not observed in any of the cases. CONCLUSIONS In pediatric patients with MMD who are extubated after revascularization surgery, DEX produced appropriate light sedation and analgesia. The risk for symptomatic infarction is almost the same in cases in which DEX is used and those in which it is not; however, neurosurgeons should be cautious of bradycardia and TNEs as potential side effects.

    DOI: 10.3171/2022.6.PEDS2241

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  11. Medical Management of a Mural Thrombus Inducing Repeated Ischemic Strokes in a Patient with Congenital Afibrinogenemia 国際誌

    Nishihori Masahiro, Araki Yoshio, Suzuki Nobuaki, Tamura Shogo, Hattori Mayo, Izumi Takashi, Goto Shunsaku, Yokoyama Kinya, Uda Kenji, Matsushita Tadashi, Saito Ryuta

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   31 巻 ( 7 ) 頁: 106526 - 106526   2022年7月

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    記述言語:英語   出版者・発行元:Journal of Stroke and Cerebrovascular Diseases  

    Objectives: Congenital afibrinogenemia is an autosomal recessive inherited disorder that can cause thrombotic as well as hemorrhagic events. We describe a case of repeated mild ischemic strokes due to a mural thrombus in the carotid artery and our medical treatment. Case description: A 49-year-old woman with congenital afibrinogenemia developed two minor ischemic strokes in two months. Clinical images revealed scattered fresh infarcts in the right middle cerebral artery region and mild cervical carotid artery stenosis. The risk for surgical treatment was considered to be extraordinarily high. The patient was treated with 100 mg/day of aspirin and 3 g fibrinogen infusion every two weeks. After the one-year course of medication, the mural thrombus gradually decreased, and there were no bleeding or ischemic stroke events. Conclusion: This case report highlights the successful treatment of an ischemic stroke in a patient with a congenital afibrinogenemia with an antiplatelet agent and fibrinogen replacement. There are no guidelines for managing ischemic stroke in patients with congenital afibrinogenemia, and further studies are needed.

    DOI: 10.1016/j.jstrokecerebrovasdis.2022.106526

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  12. Changes in cerebral blood flow in the postoperative chronic phase after combined cerebral revascularization for moyamoya disease with ischaemic onset 国際誌

    Araki Yoshio, Mamiya Takashi, Fujita Naotoshi, Uda Kenji, Yokoyama Kinya, Kanamori Fumiaki, Takayanagi Kai, Ishii Kazuki, Nishihori Masahiro, Takeuch Kazuhito, Tanahashi Kuniaki, Nagata Yuichi, Nishimura Yusuke, Tanei Takafumi, Sumitomo Masaki, Okamoto Sho, Izumi Takashi, Kato Katsuhiko, Saito Ryuta

    NEUROSURGICAL REVIEW   45 巻 ( 3 ) 頁: 2471 - 2480   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Neurosurgical Review  

    The purpose of this study was to examine the effects of combined revascularization for ischaemic-onset moyamoya disease (MMD) on cerebral haemodynamics by comparing cerebral blood flow (CBF) during the postoperative chronic phase with preoperative CBF. A retrospective cohort of 24 MMD patients (representing 31 surgeries) who received single photon emission computed tomography (SPECT) before and more than 6 months after surgery was investigated. The CBF value of each vascular territory was extracted from SPECT data, and the value relative to the ipsilateral cerebellar value (relative CBF, or RCBF) was calculated. The correlation between the revascularization effect and the proportional change in RCBF before and after surgery (calculated as post-RCBF/pre-RCBF (“post/pre-RCBF”)) was analysed. Furthermore, the relationships between changes in neurological symptoms and post/pre-RCBF were investigated. Preoperative and postoperative mean RCBF values were 0.92 ± 0.15 and 0.96 ± 0.13 (p = 0.619) in the anterior cerebral artery territory, 0.99 ± 0.17 and 1.01 ± 0.17 (p = 0.598) in the middle cerebral artery territory and 1.15 ± 0.22 and 1.14 ± 0.19 (p = 0.062) in the posterior cerebral artery territory, respectively. No significant correlation was found between the revascularization score and post/pre-RCBF. The revascularization score and post/pre-RCBF were not significant predictors of worsening neurological symptoms postoperatively. No significant change in RCBF was observed in any vascular territory in the chronic phase after revascularization. Combined revascularization may assist in the redirection of blood flow from the internal to the external carotid system and contribute to CBF maintenance.

    DOI: 10.1007/s10143-022-01774-8

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  13. Evaluation of the differences in pressure applied to the vessel wall by different types of balloon remodeling microcatheters in an experimental model

    Ikezawa Mizuka, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Tamari Yosuke, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Goto Shunsaku, Kropp Asuka E., Otsuka Takafumi, Kato Naoki, Nakano Mizuki, Saito Ryuta

    INTERVENTIONAL NEURORADIOLOGY   28 巻 ( 3 ) 頁: 323 - 331   2022年6月

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    記述言語:日本語   出版者・発行元:Interventional Neuroradiology  

    Background: We examined compliance differences among balloon remodeling microcatheters, which have not been established previously. Methods: Straight and 120° angulated vascular models were created in a 3 mm diameter tube with 3 mm hole (vascular model A), a tube with a 4 mm hole (vascular model B), and a 4 mm diameter tube (vascular model C). We compared the pressure exerted when each balloon was herniated 1 or 2 mm between three compliant balloons (SHOURYU SR, TransForm C, and Scepter C) and four super-compliant balloons (HyperForm, SHOURYU HR, TransForm SC, and Scepter XC). Results: In vascular model A, there was a significant difference in the pressure exerted by compliant balloons and super-compliant balloons in both the straight and angulated models. In the straight model (1 and 2 mm), the lowest pressure was exerted by HyperForm (super-compliant balloons group) and SHOURYU SR (compliant balloons group). The lowest pressure was exerted in the angulated model by HyperForm (super-compliant balloons group) and Scepter C (compliant balloons group). The Scepter balloon exerted higher pressure in the straight model than other balloon remodeling microcatheters but less in the angulated model. In vascular model B, the pressure decreased in all balloons compared with model A. In vascular model C, the pressure increased in all balloons compared with model A. Conclusions: Pressure differed across balloon remodeling microcatheters. In addition, vessel shape and diameter, and hole size, affected the results. Our findings can help select balloon remodeling microcatheters.

    DOI: 10.1177/15910199211031765

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  14. Blood flow stagnation after treatment of a giant internal carotid artery aneurysm: a computed fluid dynamics analysis 査読有り 国際誌

    Muraoka Shinsuke, Takagi Reiya, Araki Yoshio, Uda Kenji, Sumitomo Masaki, Okamoto Sho, Nishihori Masahiro, Izumi Takashi, Nakamura Masanori, Saito Ryuta

    SCIENTIFIC REPORTS   12 巻 ( 1 ) 頁: 7283 - 7283   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Scientific Reports  

    Balloon test occlusion (BTO) is an angiographic test to evaluate ischemic tolerance after permanent occlusion of an internal carotid artery (ICA). BTO can simulate ischemia caused by parent artery occlusion and can be used to select a suitable bypass surgery using specific criteria. On the other hand, a postoperative thrombus can form despite proper case selection, optimal radiological evaluation, and an appropriate surgical strategy. Postoperative ischemic complications related to perforating branches are clinically significant. This simulation study aimed to analyze postoperative flow characteristics and elucidate the cause of ischemic complications related to the perforating branch using computational fluid dynamics (CFD). An unexpected postoperative thrombus formation related to the perforating branch occurred after treating a giant aneurysm in the cavernous portion of the ICA in a patient. Three-dimensional digital subtraction angiography was used to acquire flow data and set up the CFD simulation. The flow simulations were performed at various bypass flow rates. The CFD analysis indicated flow stagnation in the ICA only when surgical treatment using a low-flow bypass graft was performed. Thrombus formation may lead to ischemic complications related to the perforating branch, such as the anterior choroidal artery. BTO did not reflect the influence of bypass blood flow. Therefore, recognizing that blood flow stagnation may occur and comprehensively deciding on the surgical strategy by CFD analysis can be helpful to prevent ischemic complications in patients with giant aneurysms.

    DOI: 10.1038/s41598-022-11321-6

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  15. Risk Factors for Cerebral Infarction Early After Revascularization in Children Younger than 5 Years with Moyamoya Disease 国際誌

    Araki Yoshio, Uda Kenji, Yokoyama Kinya, Kanamori Fumiaki, Kurimoto Michihiro, Shiba Yoshiki, Mamiya Takashi, Nishihori Masahiro, Takeuchi Kazuhito, Tanahashi Kuniaki, Nagata Yuichi, Nishimura Yusuke, Okamoto Sho, Sumitomo Masaki, Izumi Takashi, Saito Ryuta

    WORLD NEUROSURGERY   160 巻   頁: E220 - E226   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:World Neurosurgery  

    Objective: Cerebral revascularization is necessary for pediatric patients younger than 5 years with moyamoya disease (MMD). However, they have a high risk of developing cerebral infarction early after surgery. This study aimed to analyze the risk factors for developing cerebral infarction among these patients. Methods: The charts of 21 consecutive patients with MMD (39 surgeries) younger than 5 years who had undergone revascularization at our hospital were retrospectively analyzed. Because cerebral infarction occurring within 1 month after surgery was the primary end point, other clinical information was evaluated, including each surgical procedure. Multivariate analysis of the risk factors for postoperative cerebral infarction was performed. Results: Cerebral infarction occurred after 7 of 39 surgeries (17.9%). Of the 39 surgeries, 23 (59%) included direct and indirect combined revascularization. The incidence of cerebral infarction did not differ significantly between the combined (21.7%) and indirect (12.5%) groups (P = 0.46). Logistic regression showed no association between the revascularization procedure and the occurrence of cerebral infarction after surgery (P = 0.3). However, younger age at surgery was correlated with a higher risk of developing cerebral infarction in the early postoperative period (P = 0.05). Conclusions: No differences were found in the risk of developing cerebral infarction early after surgery as a result of surgical procedures. However, younger patients had higher postoperative risk. Further multicenter research should examine this issue for young pediatric patients with moyamoya at high risk of developing cerebral infarction.

    DOI: 10.1016/j.wneu.2021.12.115

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  16. Challenging direct bypass surgery for very young children with moyamoya disease: technical notes 国際誌

    Araki Yoshio, Uda Kenji, Yokoyama Kinya, Kanamori Fumiaki, Kurimoto Michihiro, Shiba Yoshiki, Mamiya Takashi, Nishihori Masahiro, Takeuchi Kazuhito, Tanahashi Kuniaki, Nagata Yuichi, Nishimura Yusuke, Okamoto Sho, Sumitomo Masaki, Izumi Takashi, Saito Ryuta

    NEUROSURGICAL REVIEW   45 巻 ( 2 ) 頁: 1799 - 1807   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Neurosurgical Review  

    Cerebral revascularization for moyamoya disease (MMD) is an effective treatment for improving cerebral ischaemia and preventing rebleeding. Although direct bypass surgery is commonly performed on older children and adults, it is challenging in very young children due to the high difficulty level of the procedure. The subjects were MMD patients under 3 years of age on whom surgery was performed by a single surgeon (Y.A.). Preoperative clinical findings, information related to direct bypass surgery, bypass patency, and the incidence of postoperative stroke were investigated. Combined revascularization, including direct bypass surgery, was performed on 3 MMD patients (3 sides) under 3 years of age. The average diameter of the grafts used in direct bypass was 0.8 mm. The average recipient diameter was 0.8 ± 0.17 (range 0.6–1) mm. In all cases, the anastomotic procedure was completed using 11–0 monofilament nylon thread, and patency was confirmed. Direct bypass for MMD patients under 3 years old is technically challenging. However, despite the anatomical differences between very young children and elderly individuals, direct bypass surgery could certainly be completed. In addition, a rapid recovery from cerebral blood flow insufficiency could yield a promising neurological outcome.

    DOI: 10.1007/s10143-021-01685-0

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  17. Advantages of petrosectomy for superficial temporal artery to superior cerebellar artery bypass based on three-dimensional distance measurements using cadaver heads

    Uda Kenji, Tanahashi Kuniaki, Mamiya Takashi, Kanamori Fumiaki, Yokoyama Kinya, Nishihori Masahiro, Izumi Takashi, Araki Yoshio, Saito Ryuta

    NEUROSURGICAL REVIEW   45 巻 ( 2 ) 頁: 1617 - 1624   2022年4月

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    記述言語:英語   出版者・発行元:Neurosurgical Review  

    Superficial temporal artery (STA) to superior cerebellar artery (SCA) bypass is usually performed via the subtemporal approach (StA), anterior transpetrosal approach (ApA), or combined petrosal approach (CpA), but no study has yet reported a quantitative comparison of the operative field size provided by each approach, and the optimal approach is unclear. The objective of this study is to establish evidence for selecting the approach by using cadaver heads to measure the three-dimensional distances that represent the operative field size for STA–SCA bypass. Ten sides of 10 cadaver heads were used to perform the four approaches: StA, ApA with and without zygomatic arch osteotomy (ApA-ZO− and ApA-ZO+), and CpA. For each approach, the major-axis length and the minor-axis length at the anastomosis site (La-A and Li-A), the major-axis length and the minor-axis length at the brain surface (La-B and Li-B), the depth from the brain surface to the anastomosis site (Dp), and the operating angles of the major axis and the minor axis (OAa and OAi) were measured. Shallower Dp and wider operating angle were obtained in the order CpA, ApA-ZO+, ApA-ZO−, and StA. In all parameters, ApA-ZO− extended the operative field more than StA. ApA-ZO+ extended La-B and OAa more than ApA-ZO−, whereas it did not contribute to Dp and OAi. CpA significantly decreased Dp, and widened OAa and OAi more than ApA-ZO+. ApA and CpA greatly expanded the operative field compared with StA. These results provide criteria for selecting the optimal approach for STA-SCA bypass in light of an individual surgeon’s anastomosis skill level.

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  18. Spatially separate cerebral infarction in the posterior cerebral artery territory after combined revascularization of the middle cerebral artery territory in an adult patient with moyamoya disease and fetal-type posterior communicating artery: illustrative case. 国際誌

    Araki Y, Yokoyama K, Uda K, Kanamori F, Mamiya T, Takayanagi K, Ishii K, Nishihori M, Takeuchi K, Tanahashi K, Nagata Y, Tanei T, Nishimura Y, Izumi T, Saito R

    Journal of neurosurgery. Case lessons   3 巻 ( 12 )   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3171/CASE21704

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  19. Comparison of hemodynamic stress in healthy vessels after parent artery occlusion and flow diverter stent treatment for internal carotid artery aneurysm

    Tsukada Tetsuya, Izumi Takashi, Isoda Haruo, Nishihori Masahiro, Kropp A. Elisabeth, Mizuno Takashi, Wakabayashi Toshihiko

    JOURNAL OF NEUROSURGERY   136 巻 ( 3 ) 頁: 619 - 626   2022年3月

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    記述言語:英語   出版者・発行元:Journal of Neurosurgery  

    OBJECTIVE De novo aneurysms generally develop in healthy vessels after parent artery occlusion for large internal carotid artery (ICA) aneurysm, possibly owing to increased hemodynamic stress in the remaining vessels. In recent years, there has been a shift toward flow diverter stent treatment. However, there is a lack of direct evidence and data that prove this change in hemodynamic stress in healthy vessels after parent artery occlusion and flow diverter stent treatment. The authors compared hemodynamic stress in healthy-side vessels before and after parent artery occlusion and flow diverter treatments. METHODS The authors included patients who underwent 3D cine phase-contrast MRI before and after large ICA aneurysm treatment. Spatially and temporally averaged volume flow rates and spatially averaged systolic wall shear stress (WSS) in healthy-side ICA distal to the posterior communicating artery (C1 segment according to Fisher's classification) were measured before and after parent artery occlusion and flow diverter treatments. RESULTS Seventeen patients were included (5 patients in the parent artery occlusion group and 12 in the flow diverter group). At 1-2 months after treatment, median volume flow rate in healthy-side ICA increased from 5.36 ml/sec to 6.28 ml/sec (total increase 117%, p = 0.04) in the parent artery occlusion group and from 4.65 ml/sec to 4.93 ml/sec (total increase 106%, p = 0.02) in the flow diverter group. In the parent artery occlusion group, median WSS in the C1 segment of the healthy-side ICA increased from 3.91 Pa to 5.61 Pa (total increase 143%, p = 0.08); however, no significant increase was observed in the flow diverter group (4.29 Pa to 4.57 Pa [total increase 107%, p = 0.21]). CONCLUSIONS Postoperatively, volume flow rate and WSS in the C1 segment of the healthy-side ICA significantly increased in the parent artery occlusion group. Therefore, the parent artery occlusion group was more prone to de novo aneurysm than the flow diverter group.

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  20. Paradoxical symptomatic cerebral blood flow decreases after combined revascularization surgery for patients with pediatric moyamoya disease: illustrative case. 国際誌

    Araki Y, Yokoyama K, Uda K, Kanamori F, Kurimoto M, Shiba Y, Mamiya T, Takayanagi K, Ishii K, Nishihori M, Takeuchi K, Tanahashi K, Nagata Y, Nishimura Y, Okamoto S, Sumitomo M, Izumi T, Saito R

    Journal of neurosurgery. Case lessons   3 巻 ( 3 )   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3171/CASE21628

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  21. Atypical Incomplete Detachment Following PulseRider Deployment

    Goto Shunsaku, Izumi Takashi, Nishihori Masahiro, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Saito Ryuta

    Journal of Neuroendovascular Therapy   16 巻 ( 8 ) 頁: 409 - 412   2022年

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    記述言語:英語   出版者・発行元:The Japanese Society for Neuroendovascular Therapy  

    <p><b>Objective</b>: Owing to the limited time since the introduction of the PulseRider (PR), inconsequential or rare complications that clinicians should be aware of remain unreported yet. Here, we report a rare complication of incomplete detachment.</p><p><b>Case Presentation</b>: A 50-year-old male underwent PR-assisted coil embolization for a basilar tip aneurysm. Coiling was completed, and the detachment procedure was performed using a detachment machine; the success signal was observed. The delivery microcatheter was subsequently advanced back up to the proximal markers, and no reapproximation of the proximal markers, which indicates successful detachment, was observed. However, only one of the proximal markers returned to the microcatheter, and incomplete detachment of only one leg was detected. Ultimately, electrical detachment was not possible, and physical separation by tension was achieved.</p><p><b>Conclusion</b>: Our case report presents a rare case of a detachment problem in the PR. The PR could not be detached, although the signal revealed successful detachment. Therefore, careful withdrawal of the delivery wire by checking not only the proximal markers but also the behavior of the entire PR and coil complex is important.</p>

    DOI: 10.5797/jnet.cr.2021-0095

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  22. Contrast-Enhanced Magnetic Resonance Imaging Suggested a Possibility of Transvenous Embolization in the Superior Petrosal Sinus Dural Arteriovenous Fistula: A Case Report

    Nishihori Masahiro, Izumi Takashi, Tsukada Tetsuya, Kato Yutaka, Uda Kenji, Yokoyama Kinya, Araki Yoshio, Saito Ryuta

    Journal of Neuroendovascular Therapy   16 巻 ( 3 ) 頁: 163 - 169   2022年

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    記述言語:英語   出版者・発行元:The Japanese Society for Neuroendovascular Therapy  

    <p><b>Objective</b>: Superior petrosal sinus dural arteriovenous fistula (SPS-DAVF) is a rare subtype of intracranial DAVF that sometimes leads to hemorrhagic symptoms following deep venous drainage. Here we report the case of SPS-DAVF with retrograde venous reflux to the cerebellar vein. Preoperative contrast-enhanced MRI was a decisive factor in a safe and effective treatment.</p><p><b>Case Presentation</b>: A 37-year-old woman was referred to our hospital with abnormal MRI findings, which was performed when she had a mild headache during her check-up. DSA revealed left-sided SPS-DAVF, which was diagnosed as Cognard type IIb. Both CTA and DSA could not detect the whole SPS but only the shunt pouch. Using contrast-enhanced MRI, we were able to visualize the presence of the SPS and its continuity within the shunt pouch. 3D-T1 turbo spin echo (SPACE) showed a low-intensity area in the SPS, which was not seen in the 3D-T1 fast field echo (FFE). During the procedure, there was a point where it was difficult to advance the microcatheter, which coincided with the low-intensity area. We achieved effective transvenous embolization from the occluded venous access by devising a surgical technique.</p><p><b>Conclusion</b>: In addition to the contrast-enhanced 3D-T1 FFE, 3D-T1 SPACE might provide beneficial information for endovascular therapy in the evaluation of venous sinuses, which could not be detected by standard examinations.</p>

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  23. The preoperative focal cerebral blood flow status may be associated with slow flow in the bypass graft after combined surgery for moyamoya disease. 国際誌

    Araki Y, Yokoyama K, Uda K, Kanamori F, Mamiya T, Takayanagi K, Ishii K, Shintai K, Nishihori M, Tsukada T, Takeuchi K, Tanahashi K, Nagata Y, Nishimura Y, Tanei T, Nagashima Y, Muraoka S, Izumi T, Seki Y, Saito R

    Surgical neurology international   13 巻   頁: 511 - 511   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Surgical Neurology International  

    Background: The aim of this study was to investigate the association between early postoperative slow flow in bypass grafts and preoperative focal cerebral blood flow (CBF) in patients who underwent combined surgery for moyamoya disease (MMD). Methods: The subjects were 18 patients (22 surgeries) who underwent single photon emission computed tomography (SPECT) before surgery. The CBF value of the middle cerebral artery territory was extracted from the SPECT data, and the value relative to the ipsilateral cerebellar CBF (relative CBF, or RCBF) was calculated. The association between RCBF and early postoperative slow flow in the bypass graft was investigated. In addition, the correlation between the revascularization effect and preoperative RCBF was analyzed. Results: In four of 22 surgeries (18.2%), slow flow in the bypass graft was identified in the early postoperative period. Preoperative RCBF in the slow flow and patent groups was 0.86 ± 0.15 and 0.87 ± 0.15, respectively, with no significant difference (P = 0.72). The signal intensity of four slow-flowed bypasses was improved in all cases on magnetic resonance angiography images captured during the chronic phase (mean of 3.3 months postoperatively). The revascularization scores were 2 ± 0.82 and 2.1 ± 0.68 in the slow flow and patent groups, respectively, and did not differ significantly (P = 0.78). A significant correlation was not observed between preoperative RCBF and the revascularization effect. Conclusion: No significant association was observed between preoperative RCBF and early postoperative slow flow in bypass grafts in patients with MMD undergoing combined surgery. Given the high rate of improved depiction of slow-flowed bypass in the chronic postoperative phase, the conceptual significance of an opportune surgical intervention is to maintain CBF by supporting the patient's own intracranial-extracranial conversion function.

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  24. Postoperative stroke and neurological outcomes in the early phase after revascularization surgeries for moyamoya disease: an age-stratified comparative analysis 国際誌

    Araki Yoshio, Yokoyama Kinya, Uda Kenji, Kanamori Fumiaki, Kurimoto Michihiro, Shiba Yoshiki, Mamiya Takashi, Nishihori Masahiro, Izumi Takashi, Sumitomo Masaki, Okamoto Sho, Matsui Kota, Emoto Ryo, Wakabayashi Toshihiko, Matsui Shigeyuki, Natsume Atsushi

    NEUROSURGICAL REVIEW   44 巻 ( 5 ) 頁: 2785 - 2795   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Neurosurgical Review  

    Stroke and neurological outcomes in the early phase following revascularization for moyamoya disease (MMD) may depend on the patient’s age. In this study, an age-stratified comparative analysis was performed to clarify this issue. We reviewed 105 MMD patients who underwent 179 revascularization surgeries. The demographic characteristics were collected in four age groups (≤ 5 and 6–17 years for pediatric patients and 18–49 and ≥ 50 years for adults). Additionally, we assessed the incidence of subsequent stroke and deterioration of modified Rankin Scale (mRS) score. Then, we evaluated predictors of postoperative stroke and mRS deterioration using logistic regression. The mean patient age was 26.2 ± 18.5 years. No significant difference in the incidence of postoperative stroke was observed between age groups; however, the incidence tended to be increased among patients aged ≤ 5 years (17.9%) and patients aged ≥ 50 years (16.7%). Deterioration of mRS scores was significantly associated with ages ≤ 5 years (17.9%) and ≥ 50 years (11.1%). Logistic regression showed that posterior cerebral artery involvement (odds ratio [OR], 4.6) and postoperative transient neurological events (TNEs) (OR, 5.93) were risk factors for postoperative stroke. Age ≤ 5 years (OR, 9.73), postoperative TNEs (OR, 7.38), and postoperative stroke (OR, 49) were identified as predictors of unfavorable neurological outcomes. The novel feature of this comparative analysis by age group is that membership in the early-childhood MMD patient group (under 5 years old) was an independent risk factor for unfavorable short-term neurological outcomes and was mainly associated with the incidence of postoperative severe cerebral infarction.

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  25. Triggering of Carotid Sinus Reflex during Deployment the Flow-diverter Device

    Goto Shunsaku, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Araki Yoshio, Uda Kenji, Yokoyama Kinya, Saito Ryuta

    NEUROLOGIA MEDICO-CHIRURGICA   61 巻 ( 10 ) 頁: 583 - 590   2021年10月

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    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    The carotid sinus reflex (CSR) is a rare complication of the Pipeline Embolization Device (PED) deployment. No study has assessed the potential risk factors in a case series. The purpose of this study was to examine CSR triggering during PED deployment. Thirty-seven consecutive patients who underwent PED deployment were included. All procedures were performed under local anesthesia with mild sedation. We retrospectively analyzed patient characteristics, PED deployment time, and vital signs during the procedure. The vital signs included the pulse rate (PR) and systolic blood pressure (SBP) obtained at three timepoints (pre-deployment, during deployment, post-deployment). We examined the triggering of the CSR during PED deployment by comparing the vital signs at the three timepoints. Moreover, risk factors for CSR were analyzed with univar-iate analysis. The patients’ average age was 66.3 years. The average size of the aneurysm was 18.0 mm. Six patients (16.2%) showed a decline in the SBP or PR defined as CSR. One patient had a transient cardiac arrest and two had severe transient bradycardia. Deployment into the ophthalmic segment of the internal carotid artery (C2 segment) aneurysm (p = 0.022), prolonged PED deployment time more than 14.5 minutes (p = 0.005), and an acute angle of the anterior genu less than 51.5 degrees (p = 0.005) were risk factors in triggering CSR. CSR may be triggered during PED deployment under local anesthesia with mild sedation. Deployment to the C2 segment aneu-rysm, prolonged PED deployment time, and an acute angle of the anterior genu were associated with CSR triggering.

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  26. Streak Metal Artifact Reduction Technique in Cone Beam Computed Tomography Images after Endovascular Neurosurgery

    Otsuka Takafumi, Nishihori Masahiro, Izumi Takashi, Uemura Takeshi, Sakai Takashi, Nakano Mizuki, Kato Naoki, Kanamori Fumiaki, Tsukada Tetsuya, Uda Kenji, Yokoyama Kinya, Araki Yoshio, Saito Ryuta

    NEUROLOGIA MEDICO-CHIRURGICA   61 巻 ( 8 ) 頁: 468 - 474   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:一般社団法人 日本脳神経外科学会  

    Cone beam computed tomography (CBCT) images are degraded by artifacts due to endovascular implants. We evaluated the use of streak metal artifact reduction technique (SMART) in non-contrast CBCT images after endovascular neurosurgery obtained from 148 patients (125 with aneurysm and 23 with dural arteriovenous fistula [dAVF]). Three neurosurgeons evaluated the cistern and brain surface visibility in CBCT images with and without SMART correction based on a 4-point scale (1, excellent; 2, good; 3, limited; and 4, insufficient). Significant improvement in visibility was achieved when the median scores improved from 4 or 3 to 2 or 1 or from 2 to 1. Metal artifact reduction in adjacent slices without metal and new artifacts after SMART correction was also examined. A significant improvement was achieved regarding the visibility of the cistern in 90 (60.8%) images and of the brain surface in 108 (73.0%) images. Metal size (cistern: odds ratio [OR], 0.91 per 1 mm increase; 95% confidence interval [CI], 0.83–0.99), irregular metal shape (cistern: OR, 0.18; 95% CI, 0.05–0.60 and brain surface: OR, 0.15; 95% CI, 0.05–0.45), and infratentorial lesions (cistern: OR, 0.37; 95% CI, 0.14–0.96 and brain surface: OR, 0.30; 95% CI, 0.11–0.80) were negatively correlated with improved visibility. Metal artifact reduction in adjacent slices without metal was obtained in 25.6% and 34.8% of images with aneurysm and dAVF, respectively. New artifacts after SMART correction were found in 4.8% and 13.0% of images with aneurysm and dAVF, respectively. SMART is especially effective for supratentorial small aneurysms.

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  27. Indocyanine green emission timing of the recipient artery in revascularization surgery for moyamoya disease

    Kanamori Fumiaki, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Mamiya Takashi, Nishihori Masahiro, Izumi Takashi, Okamoto Sho, Natsume Atsushi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   83 巻 ( 3 ) 頁: 523 - 534   2021年8月

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    記述言語:英語   出版者・発行元:Nagoya Journal of Medical Science  

    In superficial temporal artery to middle cerebral artery anastomosis with indirect revascularization for patients with moyamoya disease, the optimal method for selecting the most appropriate cortical artery for the recipient in anastomosis has not been established. We investigated the relationship between the fluorescence emission timing of the recipient artery in the preanastomosis indocyanine green videoangiography and operative outcomes. This retrospective study included 51 surgical revascularization procedures for 39 moyamoya disease patients. The enrolled surgical procedures were classified into three groups based on the fluorescence emission timing of the recipient artery in preanastomosis indocyanine green videoangiography: the EARLIEST, the INTERMEDIATE, and the LATEST. Clinical characteristics and operative outcomes were also collected. The occurrence of white thrombus at the anastomosis site and symptomatic hyperperfusion showed significant differences between the groups classified by the fluorescence emission timing of the recipient artery in preanastomosis indocyanine green videoangiography (white thrombus, p = 0.001; symptomatic hyperperfusion, p = 0.026). The development of white thrombi was significantly higher in the LATEST group, and all symptomatic hyperperfusion was observed in the EARLIEST group. These results indicated that the LATEST group had a significantly higher risk for developing white thrombus, and the EARLIEST group was prone to occur symptomatic hyperperfusion. Selecting the recipient artery based on evaluating the fluorescence emission timing in preanastomosis indocyanine green videoangiography may be useful in reducing perioperative complications.

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  28. Evaluation of the Straightening Phenomenon of Various Types of Coils

    Ishida Mamoru, Izumi Takashi, Araki Yoshio, Nishihori Masahiro, Yokoyama Kinya, Uda Kenji, Tsukada Tetsuya, Wakabayashi Toshihiko

    NEUROLOGIA MEDICO-CHIRURGICA   61 巻 ( 6 ) 頁: 356 - 360   2021年6月

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    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    The straightening phenomenon is known as a cause of catheter kickback in the late phase of coil embolization. The mechanism is supposed to be the relative shortage of the stretch resistance (SR) line, and it occurs when a coil is folded too small. Among many SR coils available, there should be a coil-specific tendency to cause this phenomenon. Here, we conducted an in-vitro experiment to know which coil is the most resistant to the straightening phenomenon. We developed an experimental model to reproduce the straightening phenomenon. Five different coils (Axium Prime, ED Coil, Hypersoft, SMART Coil, and Target 360 nano) of the same size (3 mm × 6 cm) were investigated for five times each. Resistance to the straightening phenomenon, which is represented by the insertion length at the onset of the phenomenon, was compared among coil types. The straightening phenomenon was successfully observed in all insertions. Insertion lengths were significantly different among coil types (p = 0.013). The insertion length of ED was the longest (mean ± SD, 27.0 ± 8.3 mm), which means the most resistant to the phenomenon. Axium was second (21.6 ± 7.0 mm), followed by Target (15.8 ± 6.9 mm), Hypersoft (13.8 ± 5.8 mm), and SMART (12.4 ± 4.7 mm). Difference between ED and Hypersoft (p = 0.037) and difference between ED and Smart (p = 0.018) were significant. ED coil was the one with the most resistance to the straightening phenomenon. Selecting the optimal coil is the key to avoid the phenomenon.

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  29. Effects of aspirin and heparin treatment on perioperative outcomes in patients with Moyamoya disease 査読有り 国際誌

    Kanamori Fumiaki, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Mamiya Takashi, Nishihori Masahiro, Izumi Takashi, Okamoto Sho, Natsume Atsushi

    ACTA NEUROCHIRURGICA   163 巻 ( 5 ) 頁: 1485 - 1491   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Acta Neurochirurgica  

    Background: When superficial temporal artery-middle cerebral artery bypass is combined with indirect methods (e.g., revascularization surgery) to treat Moyamoya disease (MMD), antiplatelet treatment can impact bypass patency, infarction, or hemorrhage complications. Recently, heparin has been proposed as an anticoagulant treatment against white thrombus at the anastomosis site. The study aims to evaluate the effect of aspirin on the perioperative outcomes and investigate the results of heparin treatment for white thrombus. Methods: This retrospective study included 74 procedures of combined revascularization surgery for MMD patients who either received or did not receive aspirin. Perioperative outcomes were compared between the two groups. In addition, the effects of heparin treatment for white thrombus were evaluated. Results: The rate of white thrombus at the anastomosis site was significantly higher in the non-aspirin medication group (univariate: p = 0.032, multivariate: p = 0.044) and, accordingly, initial bypass patency was lower in the non-aspirin medication group (p = 0.049). Of the 17 patients with white thrombus development, five received heparin injections, and all white thrombi disappeared; however, there was one case of epidural hematoma and another of subdural hematoma. The risk of hemorrhagic complications was significantly higher in the surgical procedures that received heparin injections (p = 0.021). Conclusions: In MMD patients who received combined revascularization surgery, aspirin medication lowered the occurrence of white thrombus. Heparin injections help to treat white thrombus but can enhance the risk of hemorrhagic complications.

    DOI: 10.1007/s00701-020-04668-0

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  30. Ipsilateral late stroke after revascularization surgery for patients with Moyamoya disease

    Araki Yoshio, Yokoyama Kinya, Uda Kenji, Kanamori Fumiaki, Mamiya Takashi, Nishihori Masahiro, Sumitomo Masaki, Okamoto Sho, Izumi Takashi

    ACTA NEUROCHIRURGICA   163 巻 ( 5 ) 頁: 1493 - 1502   2021年5月

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    記述言語:英語   出版者・発行元:Acta Neurochirurgica  

    Background: Ipsilateral late stroke events occurring after cerebral revascularization for Moyamoya disease (MMD) and their risk factors have not been fully investigated. Methods: We retrospectively analyzed 123 patients with MMD who underwent 212 revascularizations. We investigated preoperative demographic data, surgical procedures, and ipsilateral stroke events occurring more than 1 month after surgery. The effect of revascularization and the residual Moyamoya vessel (MMV) score were examined using magnetic resonance angiography (MRA). Then, predictive factors for postoperative late stroke occurrence were evaluated by logistic regression. Results: The mean age was 26 ± 18.4 years (range 1 to 66 years). Ipsilateral late stroke events were present in 11 of 123 (9%) patients. Stroke occurred in 11 out of 212 surgeries (5.2%) on a hemispheric basis. During the 1300.1 hemisphere-years of follow-up more than 1 month after surgery, the annual stroke rate was 0.84%. The postoperative MRA time-of-flight image showed a mean revascularization score of 1.82 ± 0.6 and a mean residual MMV score of 1.91 ± 0.83. Postoperative strokes occurring within 1 month after cerebral revascularization (36.4%, p = 0.0026) and lower revascularization scores (1.82 ± 0.6 vs 2.51 ± 0.59, p = 0.0006) were significant factors related to the presence of ipsilateral late stroke. Logistic regression showed that stroke events within 1 month after revascularization (odds ratio [OR], 9.79; 95% confidence interval [CI], 0.02–0.57; p = 0.0103), low revascularization score (OR, 0.15; 95% CI, 0.001–0.37; p = 0.0069), and high residual MMV score (OR, 16.2; 95% CI, 1.88–187.4; p = 0.0107) were risk factors for ipsilateral stroke more than 1 month after revascularization. Conclusions: MMD patients who have a stroke within 1 month after cerebral revascularization are at high risk for late strokes. Less effective revascularization or remarkable residual MMV are risk factors for late stroke events. Additional revascularization may be considered for patients in such situations. Clinical trial registration: This study was approved by the Bioethics Review Committee of Nagoya University Hospital for the treatment and prognosis of Moyamoya disease (2016-0327).

    DOI: 10.1007/s00701-021-04773-8

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  31. Short-segment Internal Trapping for Symptomatic Thrombosed Large Fusiform Vertebral Artery Aneurysms (Bird's Nest Trapping): A Technical Note

    Nishihori Masahiro, Izumi Takashi, Tsukada Tetsuya, Kropp Asuka Elisabeth, Uda Kenji, Yokoyama Kinya, Araki Yoshio, Wakabayashi Toshihiko

    NEUROLOGIA MEDICO-CHIRURGICA   61 巻 ( 4 ) 頁: 284 - 291   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:一般社団法人 日本脳神経外科学会  

    Internal trapping with coils is an established treatment of symptomatic large non-branching thrombosed fusiform vertebral artery aneurysms (VAA). However, when perforators arise near the aneurysm neck, parent artery occlusion has a high risk of causing medullary infarction. As an alternative treatment, we performed short-segment internal trapping of the artery using n-butyl-2-cyanoacrylate (NBCA) and coils (bird’s nest trapping). Before treatment, perianeurys-mal perforators are carefully detected using high-resolution three-dimensional rotational angiog-raphy (3DRA). Double microcatheters are advanced to the distal portion of the aneurysm through a balloon guiding catheter where coils are deployed without tight packing. Then, NBCA is injected into the coil mass, taking care to preserve perforators and significant branches. The same maneu-ver is repeated in the proximal portion of the aneurysm. Coil placement is avoided within the middle of the aneurysm; however, if necessary, only a small number of coils are placed to prevent worsening of mass effect. Two quinquagenarian males presented with a large thrombosed fusi-form VAA that caused symptoms due to mass effect. In each case, perforators arose from the parent artery and short-segment internal trapping with NBCA and coils was performed. Symptoms improved after treatment and follow-up imaging confirmed aneurysm shrinkage with no long-time recurrence. In symptomatic large fusiform VAAs where the distance from the lesion to important perforators is extremely short, internal trapping using a combination of NBCA and coils can be more useful than conventional internal trapping.

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  32. Development and clinical evaluation of a contactless operating interface for three-dimensional image-guided navigation for endovascular neurosurgery 査読有り 国際誌

    Nishihori Masahiro, Izumi Takashi, Nagano Yoshitaka, Sato Masaki, Tsukada Tetsuya, Kropp Asuka Elisabeth, Wakabayashi Toshihiko

    INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY   16 巻 ( 4 ) 頁: 663 - 671   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of Computer Assisted Radiology and Surgery  

    Purpose: In endovascular neurosurgery, the operator often acquires three-dimensional (3D) images of the cerebral vessels. Although workstation reoperation is required in some situations during treatment, it leads to time loss because a sterile condition cannot be maintained and treatment must be temporarily interrupted. Therefore, a workstation reoperating system is required while maintaining the desired sterility. Methods: A contactless operating interface using Kinect to control 3D images was developed via gesture recognition for endovascular neurosurgery and was applied to a 3D volume rendering technique (VRT) image reconstructed at the workstation. The left-hand movement determines the assigned functions, whereas the right-hand movement is used like a computer mouse to pan and zoom in/out. In addition to the interface, voice commands were used and assigned to digital operations, such as image view changes and mode signal changes. Results: This system was used for the actual endovascular treatment of cerebral aneurysms and cerebral arteriovenous malformations. The operator and gesture were recognized without any problems. Using voice operation, it was possible to expeditiously set the VRT image back to the reference angle. Furthermore, it was possible to finely adjust gesture operations, including mouse operation, and treatment was completed while maintaining sterile conditions. Conclusion: A contactless operating interface was developed by combining the existing workstation system with Kinect and voice recognition software, allowing surgeons to perform a series of operations, which are normally performed in a console room, while maintaining sterile conditions.

    DOI: 10.1007/s11548-021-02330-3

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  33. Anterior Communicating Artery Aneurysm with a Peculiar Angiographic Appearance: A Case Study.

    Otawa M, Izumi T, Nishihori M, Tsukada T, Oshima R, Kawaguchi T, Goto S, Ikezawa M, Kropp AE, Wakabayashi T

    NMC case report journal   8 巻 ( 1 ) 頁: 57 - 61   2021年4月

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    記述言語:英語  

    DOI: 10.2176/nmccrj.cr.2020-0036

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  34. Analysis of relationship between superior hypophyseal artery visualization and preservation and postoperative visual field deficit in paraclinoid aneurysm

    Otawa Masato, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Oshima Ryosuke, Kawaguchi Tomomi, Goto Shunsaku, Ikezawa Mizuka, Kropp Asuka Elisabeth, Araki Yoshio, Uda Kenji, Wakabayashi Toshihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   83 巻 ( 1 ) 頁: 21 - 30   2021年2月

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    記述言語:英語   出版者・発行元:Nagoya Journal of Medical Science  

    Direct surgery for paraclinoid aneurysms can result in visual field deficit owing to compromised blood flow to the superior hypophyseal artery (SHA). However, it is rarely visualized in angiography, and discussions regarding its preservation in the field of neuro-endovascular treatment are limited. Biplane angiographic suite with high spatial resolution has been used at our institution since 2014. Since then, there were a few cases where SHAs could be visualized via digital subtraction angiography. We retrospectively analyzed the relationship between the presences and abscence of SHAs in paraclinoid aneurysms and post-procedural visual field deficit. Sixty-three paraclinoid aneuryms treated by neuro-endovascular procedure in 2014-2018 at our neurosurgery department were analyzed. Pre- and post-procedural multiplanar reconstruction imagings of three-dimensional rotation angiography were analyzed to retrospectively investigate the SHAs. SHAs were visualized in 26 patients (41%) and the median number of pre-procedurally visualized SHAs was 0 (interquartile range 0-1). Their origins were the aneurysmal necks in 11 patients (42%). In two of the 11 cases, they were noticed before coil embolization and were able to be preserved after the procedure. In the remaining nine cases, they were not pre-procedurally detected, and coiling was normally conducted. Visual field deficit occurred in one of these nine cases, but symptoms were transient, and the patient fully recovered. Because SHAs could be visualized in >40% cases and no visual field defects occurred in cases that SHAs could be identified and preserved preoperatively, we recommend their preservation during coil embolization for paraclinoid aneurysms.

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  35. Direct Vertebral Artery Puncture During Open Surgery for the Endovascular Treatment of a Recurrent Vertebro-Vertebral Arteriovenous Fistula 査読有り

    Ikezawa Mizuka, Izumi Takashi, Nishihori Masahiro, Nagashima Yoshitaka, Nishimura Yusuke, Tsukuda Tetsuya, Kropp Asuka E., Goto Shunsaku, Otsuka Takafumi, Kato Naoki, Nakano Mizuki

    WORLD NEUROSURGERY   146 巻   頁: 166 - 170   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:World Neurosurgery  

    Background: Vertebro-vertebral arteriovenous fistula (VVAVF) is a condition in which there is an arteriovenous shunt directly connecting the extracranial vertebral artery to the vertebral venous plexus. Many reports have described fistula occlusion or vertebral artery trapping as treatments for VVAVF. Here, we describe a case in which endovascular treatment for recurrent VVAVF using a transfemoral approach was unsuccessful; thus, the vertebral artery (VA) was directly punctured during open surgery and the treatment was successful. Case Description: The patient was a 47-year-old female who had undergone endovascular treatment for VVAVF. The patient developed subarachnoid hemorrhage. Digital subtraction angiography revealed a left VVAVF. The left VA was trapped with coils at the C2 and C3 levels and an arteriovenous shunt formed from the VA between the 2-coil mass to the vertebral venous plexus. In addition, reflux was observed in the spinal vein. Endovascular treatment was attempted with a transfemoral approach, but we could not reach the shunt. Five days post-treatment, the patient had a second subarachnoid hemorrhage and surgery was performed to occlude the radiculomedullary vein; however, residual reflux went into the spinal vein from another spinal level. Later, the VA was directly punctured and treated with N-butyl cyanoacrylate, and the shunt disappeared. Conclusions: Direct puncture of the vertebral artery was useful in this case, where it was difficult to reach the lesion. Although direct VA puncture is associated with more complications than the transfemoral or transbrachial approach, it may be an option when other methods are difficult.

    DOI: 10.1016/j.wneu.2020.10.156

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  36. Case-control study of postprocedural arterial puncture site hemorrhage after neuroendovascular treatment 査読有り

    Tamari Yosuke, Izumi Takashi, Nishihori Masahiro, Imai Tasuku, Ito Masashi, Tsukada Tetsuya, Ishida Mamoru, Wakabayashi Toshihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   83 巻 ( 1 ) 頁: 125 - 133   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya Journal of Medical Science  

    Puncture site hemorrhage following femoral artery catheterization is a significant cause of morbidity. The aim of this case-control study was to identify predictors of postprocedural arterial hemorrhage at the puncture site. We retrospectively reviewed 255 patients who underwent endovascular treatment at our institution over a 23-month period and classified them into a hemorrhage group and a non-hemorrhage group. Puncture site hemorrhage occurred in 15 patients (5.9%). Clinical factors associated with a significantly increased risk of puncture site bleeding included patients whose postoperative activated clotting time of ≤300 seconds before removal of the sheath (9 patients, 11.8%; P<0.05), those who received triple antiplatelet therapy (n<4, 17.4%; P<0.05) and the group administered heparin postoperatively (7 patients, 13.2%; P<0.05). The effects of low on-treatment platelet reactivity, i.e., P2Y12 reaction units <95%, sheath size, hemostasis method used, and operating time were not clinically significant. Our findings suggest an increased risk of puncture site hemorrhage in patients who either had an activated clotting time ≤300 seconds before the postoperative removal of the sheath, had received triple antiplatelet therapy, or were administered heparin postoperatively

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  37. Management of Asymptomatic Vertebral Artery Injury Caused by a Cervical Pedicle Screw Malposition: Two Case Reports.

    Otsuka T, Izumi T, Nishihori M, Tsukada T, Araki Y, Yokoyama K, Uda K, Goto S, Ikezawa M, Kato N, Nakano M, Saito R

    NMC case report journal   8 巻 ( 1 ) 頁: 713 - 717   2021年

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    記述言語:英語  

    DOI: 10.2176/nmccrj.cr.2021-0062

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  38. Levodopa-responsive Parkinsonism Caused by Recurrence of Large Basilar-tip Aneurysm after Stent-assisted Coil Embolization: A Case Report.

    Nishihori M, Izumi T, Tsukada T, Araki Y, Yokoyama K, Uda K, Wakabayashi T

    NMC case report journal   8 巻 ( 1 ) 頁: 107 - 111   2021年

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    記述言語:英語  

    DOI: 10.2176/nmccrj.cr.2020-0023

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  39. Coexistence of a Dural Arteriovenous Fistula and Pial Arteriovenous Malformation Sharing a Common Drainer.

    Uda K, Izumi T, Kanamori F, Yokoyama K, Tsukada T, Nishihori M, Shintai K, Okamoto S, Araki Y

    NMC case report journal   8 巻 ( 1 ) 頁: 557 - 563   2021年

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    記述言語:英語  

    DOI: 10.2176/nmccrj.cr.2020-0349

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  40. Efficacy of Respiratory Control under Local Anesthesia during Endovascular Therapy in the Tortuous Vertebral Artery with the Use of Respiratory Dislocation of the Aortic Arch

    Goto Shunsaku, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Ikezawa Mizuka

    Journal of Neuroendovascular Therapy   15 巻 ( 3 ) 頁: 195 - 199   2021年

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    記述言語:英語   出版者・発行元:The Japanese Society for Neuroendovascular Therapy  

    <p><b>Purpose:</b> Endovascular therapy (EVT) through the tortuous access route is increasingly performed in neurovascular procedures. In the posterior circulation through the vertebral artery (VA), ischemic complications, including vessel dissection and cerebral vessel infarction, are sometimes observed, especially during navigation of the guiding catheter, because of small vessel diameter and tortuous origin. We describe an adjunctive technique for passing the guiding catheter safely to the tortuous VA and reducing ischemic complication using respiratory displacement of the aortic arch.</p><p><b>Case Presentations:</b> The guidewire is advanced to the origin of the VA until it is caught in the tortuosity. Then we instruct the patient to take a maximum deep inspiration and hold his or her breath. In this manner, the aortic arch and side branches are dislocated to the caudal direction, which reduces the tortuosity of the VA origin and facilitates passage of the guidewire. Here, we discuss three representative cases which demonstrate that our techniques are effective in navigating the catheter to the tortuous VA.</p><p><b>Conclusion:</b> In the EVT of a patient who has a tortuous VA, respiration control under local anesthesia, maximum deep inspiration, and breath holding induce the respiratory dislocation of the aortic arch. This enables safe navigation of the guiding catheter, reduces the likelihood of interruption in blood flow, and helps avoid dissection and ischemic complications during EVT.</p>

    DOI: 10.5797/jnet.tn.2020-0109

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  41. Outcomes and Issues of ‘Drip and Go’ as an Inter-Hospital Cooperation System in Mechanical Thrombectomy for Acute Ischemic Stroke

    Nishihori Masahiro, Izumi Takashi, Tsukada Tetsuya, Yokoyama Kinya, Uda Kenji, Araki Yoshio, Wakabayashi Toshihiko

    Journal of Neuroendovascular Therapy   15 巻 ( 10 ) 頁: 629 - 636   2021年

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    記述言語:英語   出版者・発行元:The Japanese Society for Neuroendovascular Therapy  

    <p><b>Objective:</b> Mechanical thrombectomy in acute ischemic stroke (AIS) has become popular in recent years. Our affiliated institutes without neuro-endovascular specialists call our department to come to assist and perform thrombectomy (Drip and Go). In this study, the effectiveness of this inter-hospital cooperative system was evaluated.</p><p><b>Methods:</b> Between January 2016 and December 2018, “Drip and Go” was performed in a total of 29 patients (20 males, average age of 75 years) from four hospitals located within a 1-hour drive, that frequently called for AIS assistance. The background and outcomes of such cases were then retrospectively collected and evaluated.</p><p><b>Results:</b> The median National Institutes of Health Stroke Scale (NIHSS) and diffusion-weighed image-Alberta Stroke Programme Early CT Score (DWI-ASPECTS) were 19 and 7, respectively. Gro in puncture was performed in 27 patients (93%) within 6 h of onset. Good reperfusion (thrombolysis in cerebral infarction [TICI] 2b/3) was obtained in 24 patients (82%) with only one patient exhibiting hemorrhagic complication. A total of 12 patients (41%) had a modified Rankin Scale (mRS) score of 0–3 after 90 days or at the time of discharge. Univariate analysis identified a DWI-ASPECTS of 7 or higher as the only significant factor associated with a good neurological prognosis (P <0.05). Neurological prognosis was the most favorable at the furthest hospital where patients had a good DWI-ASPECTS.</p><p><b>Conclusion:</b> By employing a 1-hour arrival time window and proper patient selection, the “Drip and Go” inter-hospital cooperative system can be an alternative approach for covering areas where no neuro-endovascular specialists are available for AIS.</p>

    DOI: 10.5797/jnet.oa.2020-0097

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  42. アクセス困難な硬膜動静脈瘻症例における,対側上錐体静脈洞を経由する上錐体静脈洞へのアプローチ

    鈴木 啓太, 西堀 正洋, 泉 孝嗣, 鈴木 宰, 武藤 学, 荒木 芳生, 宇田 憲司, 横山 欣也, 齋藤 竜太

    脳血管内治療   6 巻 ( 3 ) 頁: 161 - 168   2021年

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    記述言語:日本語   出版者・発行元:特定非営利活動法人 日本脳神経血管内治療学会  

    <p>【目的】多発硬膜動静脈瘻(dural arteriovenous fistula: DAVF)の症例において,左上錐体静脈洞部(superior petrosal sinus: SPS)のシャントを右 SPS 経由で塞栓した症例を報告する.【症例】60 歳女性,意識障害の精査にて深部静脈逆流を伴う多発 DAVF を認めた.逆流に最も関与する左横静脈洞部 DAVF に対して経静脈的塞栓術を施行した.術後症状改善が乏しく,再度DSA を行うと,左 SPS へのシャントと深部静脈への逆流が明らかとなった.左横静脈洞と両側下錐体静脈洞は閉塞していたため,右 SPS と両側海綿静脈洞を経由してマイクロカテーテルをシャント部へ誘導し,左 SPS を塞栓し,逆流の消失を得た.【結論】対側 SPS を経由した SPS へのアクセスは,同側からのアクセスが困難な症例において,有効な選択肢になり得る.</p>

    DOI: 10.20626/nkc.tn.2021-0009

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  43. 破裂大型脳底動脈瘤に対するステント支援コイル塞栓術後に2 度の帝王切開による分娩を経験した1例

    加藤 直毅, 泉 孝嗣, 西堀 正洋, 塚田 哲也, 荒木 芳生, 横山 欣也, 宇田 憲司, 松原 功明, 纐纈 直樹

    脳血管内治療   6 巻 ( 1 ) 頁: 24 - 29   2021年

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    記述言語:日本語   出版者・発行元:特定非営利活動法人 日本脳神経血管内治療学会  

    <p>【目的】ステント留置後妊娠において,抗血栓療法に関する明確な基準は認めない.われわれは破裂大型脳底動脈瘤に対してステント支援コイル塞栓術を施行し,2 度の出産を経験した症例を報告する.【症例】27 歳女性.脳底動脈瘤破裂によるくも膜下出血を発症し,ステント支援コイル塞栓術を施行した.33 歳時に体外受精にて妊娠した.抗血小板剤は治療 3 年後に中止となっていたが,妊娠時の過凝固を考慮しアスピリンを開始,28 週からヘパリン皮下注射へ切り替え,帝王切開で児を分娩した.母子共に合併症なく経過した.35 歳時の妊娠も同内容の抗血栓療法を行い,合併症なく経過した.【結論】周産期抗血栓療法によって合併症なく 2 度の分娩を経験した.</p>

    DOI: 10.20626/nkc.cr.2020-0019

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  44. [Ruptured Spinal Arteriovenous Malformation Mimicking Bacterial Meningitis:A Case Report]. 査読有り

    Hiramatsu T, Nishihori M, Haraguchi K, Okada T, Endo O, Fujii K, Yokoyama H, Takayanagi K, Yamamoto N

    No shinkei geka. Neurological surgery   48 巻 ( 11 ) 頁: 1051 - 1057   2020年11月

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    担当区分:責任著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.11477/mf.1436204319

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  45. A case of internal trapping to a thrombosed giant rapidly growing aneurysm at the posterior cerebral artery

    Otawa Masato, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Oshima Ryosuke, Kawaguchi Tomomi, Goto Shunsaku, Ikezawa Mizuka, Kropp Asuka Elisabeth, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Wakabayashi Toshihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   82 巻 ( 3 ) 頁: 557 - 566   2020年8月

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    記述言語:英語   出版者・発行元:Nagoya Journal of Medical Science  

    We describe a case of internal trapping including the vasa vasorum for a thrombosed giant rapidly growing posterior cerebral artery aneurysm and performing a detailed analysis. A 48-year-old woman was followed up in our hospital for a thrombosed large posterior cerebral artery aneurysm located in the P2 segment. She initially presented after experiencing a sudden headache on two occasions. Head computed tomography and magnetic resonance imaging indicated a larger aneurysm than before. Digital subtraction angiography with balloon occlusion test was assessed, and internal trapping was sequentially conducted. We detected that the vasa vasorum originated from the posterior temporal artery. Therefore, we embolized the posterior temporal artery including the vasa vasorum using N-butyl-2-cyanoacrylate and Lipiodol. Next, the anterior temporal artery was embolized with N-butyl-2-cyanoacrylate and Lipiodol, posterior temporal artery P3 segment and the aneurysm and finally the proximal P2 segment were embolized with coils. Final vertebral and internal carotid angiography showed complete obliteration of the aneurysm. On the day after the procedure her paresis worsened and she developed left upper quadrantanopia, however was finally discharged with no hemiparesis. We reported a case of a rapidly growing thrombosed giant posterior cerebral artery aneurysm treated by parent artery occlusion including the vasa vasorum with detailed image analysis.

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  46. Surgical Designs of Revascularization for Moyamoya Disease: 15 Years of Experience in a Single Center

    Araki Yoshio, Uda Kenji, Yokoyama Kinya, Kanamori Fumiaki, Mamiya Takashi, Nishihori Masahiro, Izumi Takashi, Tanahashi Kuniaki, Masaki Sumitomo, Sho Okamoto, Wakabayashi Toshihiko, Natsume Atsushi

    WORLD NEUROSURGERY   139 巻   頁: E325 - E334   2020年7月

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    記述言語:英語   出版者・発行元:World Neurosurgery  

    Objective: Cerebral revascularization surgery has been established as an effective treatment for moyamoya disease. On the other hand, harvesting grafts and tissues to nourish the scalp may increase the risk of postoperative wound-related complications. The purpose of this study was to clarify risk factors for wound-related complications after examining the relationship with the surgical design. Methods: We retrospectively analyzed 115 patients who underwent 197 revascularization procedures between October 2004 and March 2019. The design of the revascularization was classified into 6 types, then further classified according to the number of grafts harvested, resulting in 11 subtypes. Incidences of minor and major wound-related complications for the 11 different surgical designs were assessed. The risk of complications from each design was statistically examined. In addition, the yearly transition rate of complications was also investigated. Results: Wound-related complications occurred in 38 of the 195 operations (19.5%), including 10 major events (26.3%) and 28 minor events (73.7%). Significant differences in the incidence of complications were seen according to surgical design (P < 0.05), with complications significantly more frequent for L(a) double type and L(p) double type and less frequent for L(a) single type and L(p) single type. In addition, significant differences were found in the incidence and degree of complications according to the number of grafts (0–2) (P < 0.05). The incidence of wound-related complications has clearly decreased since 2015. Conclusions: Wound-related complications were more frequent and tended to become more severe with double-bypass procedures but were clearly improved under a plastic surgery approach.

    DOI: 10.1016/j.wneu.2020.03.217

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  47. Endovascular Therapy for Intracranial Artery Stenosis: Results from the Japanese Registry of Neuroendovascular Therapy (JR-NET)3.

    Izumi T, Nishihori M, Imamura H, Iihara K, Sakai N, JR-NET investigators

    Neurologia medico-chirurgica   60 巻 ( 5 ) 頁: 256 - 263   2020年5月

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    記述言語:英語  

    DOI: 10.2176/nmc.oa.2019-0271

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  48. Brain Compression by Encephalo-Myo-Synangiosis is a Risk Factor for Transient Neurological Deficits After Surgical Revascularization in Pediatric Patients with Moyamoya Disease 査読有り

    Kanamori Fumiaki, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Nishihori Masahiro, Izumi Takashi, Okamoto Sho, Wakabayashi Toshihiko

    WORLD NEUROSURGERY   133 巻   頁: E558 - E566   2020年1月

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    記述言語:英語   出版者・発行元:World Neurosurgery  

    Objective: In pediatric patients with moyamoya disease, the pathophysiology of transient neurological deficits and the clinical features of perioperative cerebral blood flow (CBF) changes are unclear. The purpose of this study was to investigate the risk factors of postoperative transient neurological deficits and identify predictors of perioperative CBF changes. Methods: This retrospective study included 42 surgical procedures in 28 pediatric patients who underwent surgical revascularization for moyamoya disease, including encephalo-myo-synangiosis (EMS) with or without superficial temporal artery–middle cerebral artery (MCA) anastomosis. Magnetic resonance images and single photon emission computed tomography results were obtained. Brain compression by EMS was also checked in fluid attenuated inversion recovery images. Using single photon emission computed tomography, CBF was measured at each anterior and posterior part of the MCA region. Results: Postoperative transient neurological deficits were observed in 12 (28.6%) out of 42 surgical procedures. Brain compression by EMS was a significant risk for transient neurological deficits (P = 0.009). The postoperative CBF in the anterior region increased in 9 cases (21.4%) and decreased in 10 cases (23.8%); in the posterior region, it increased in 12 cases (28.6%) and decreased in 10 cases (23.8%). Preoperative CBF of the anterior region was significantly related to both perioperative CBF changes in the MCA regions (anterior part, P = 0.004; posterior part, P = 0.025). Conclusions: Brain compression by EMS is a risk factor for postoperative transient neurological deficits in pediatric patients with moyamoya disease, and preoperative CBF of the anterior MCA region could predict perioperative CBF change in the MCA regions.

    DOI: 10.1016/j.wneu.2019.09.093

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  49. 血液凝固第XIII因子濃縮製剤使用後,Galen静脈血栓症が疑われた1例

    中野 瑞生, 荒木 芳生, 金森 史哲, 宇田 憲司, 横山 欣也, 西堀 正洋, 泉 孝嗣, 吉本 真之

    脳卒中   42 巻 ( 3 ) 頁: 196 - 202   2020年

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    記述言語:日本語   出版者・発行元:一般社団法人 日本脳卒中学会  

    <p><b>要旨</b>:血液凝固第XIII 因子(F XIII)濃縮製剤使用後にGalen 静脈血栓症が疑われた1 例を報告する.76 歳女性で,意識障害により救急搬送された.前交通動脈破裂脳動脈瘤によるくも膜下出血と診断し,basal interhemispheric approach によるクリッピング術を施行した.術後4 日目に髄液鼻漏が生じ,F XIII 活性の低下を認めたためF XIII 濃縮製剤を使用した.その後髄液鼻漏は消失し,意識障害も徐々に改善傾向となるも,再度意識障害の悪化を認めた.脳血管撮影検査でGalen 静脈に狭窄所見を認め,脳静脈血栓症による意識障害と診断し,低分子ヘパリンの持続点滴後,エドキサバンの内服を継続した.出血性合併症を認めず,Galen 静脈狭窄の改善と意識障害の改善を認めた.脳静脈血栓症発症とF XIII 濃縮製剤使用の関連性が疑われ,さらに低分子ヘパリンとエドキサバンが有用である可能性が示唆された.</p>

    DOI: 10.3995/jstroke.10720

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  50. Factors influencing blood flow resistance from a large internal carotid artery aneurysm revealed by a computational fluid dynamics model

    Imai Tasuku, Izumi Takashi, Isoda Haruo, Ishiguro Kenta, Mizuno Takashi, Tsukada Tetsuya, Kropp Asuka, Ito Masashi, Nishihori Masahiro, Ishida Mamoru, Tamari Yosuke, Wakabayashi Toshihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   81 巻 ( 4 ) 頁: 629 - 636   2019年11月

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    記述言語:英語   出版者・発行元:Nagoya Journal of Medical Science  

    Hyperperfusion syndrome occurs after treatment of a large or giant cerebral aneurysm. Recently, flow-diverter stent placement has emerged as an effective treatment method for a large cerebral aneurysm, but postoperative ipsilateral delayed intraparenchymal hemorrhage occurs in a minority of cases. The mechanism underlying delayed intraparenchymal hemorrhage is not established, but one possibility is hyperperfusion syndrome. The incidence of delayed intraparenchymal hemorrhage appears to be higher for giant aneurysms; hence, we speculated that large/giant aneurysms may create flow resistance, and mitigation by flow-diverter stent deployment leads to hyperperfusion syndrome and delayed intraparenchymal hemorrhage. The purpose of this study was to identify aneurysm characteristics promoting flow resistance by the analysis of pressure loss in an internal carotid artery paraclinoid aneurysm model using computational fluid dynamics. A virtual U-shaped model of the internal carotid artery siphon portion was created with a spherical aneurysm of various angles, body diameters, and neck diameters. Visualization of streamlines, were calculated of pressure loss between proximal and distal sides of the aneurysm, and vorticity within the aneurysm were calculated. The pressure loss and vorticity demonstrated similar changes according to angle, peaking at 60°. In contrast, aneurysm diameter had little influence on pressure loss. Larger neck width, however, increases pressure loss. Our model predicts that aneurysm location and neck diameter can increase the flow resistance from a large internal carotid artery aneurysm. Patients with large aneurysm angles and neck diameters may be at increased risk of hyperperfusion syndrome and ensuing delayed intraparenchymal hemorrhage following flow-diverter stent treatment.

    DOI: 10.18999/nagjms.81.4.629

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  51. Cardiac Arrest Induced by Carotid Sinus Reflex Activation During Flow-Diverter Stent Deployment

    Goto Shunsaku, Izumi Takashi, Nishihori Masahiro, Ishida Mamoru, Ishida Tetsuya, Otawa Masato, Kawaguchi Tomoki, Oshima Ryosuke, Kropp Asuka, Ikezawa Mizuka, Wakabayashi Toshihiko

    WORLD NEUROSURGERY   124 巻   頁: 22 - 24   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:World Neurosurgery  

    Background: A 60-year-old female with multiple carotid aneurysms underwent endovascular treatment with a Pipeline Flex embolization device (PED) under local anesthesia via femoral puncture. Case Description: Cardiac arrest occurred when the delivery systems were pushed to promote adequate opening and apposition of the PED against the vessel wall and was recovered to sinus rhythm in approximately 30 seconds by pulling down the microcatheter. The carotid sinus reflex was suspected as the cause of this temporary asystole. Delivery of the PED was accompanied by application of forward pressure on the delivery system. This resulted in buckling of the delivery systems in the neck and likely excessive pressure on the carotid sinus. The procedure was continued and successfully completed with care not to excessively push the system and with the additional use of atropine. Conclusions: Although it was a rare complication, the phenomenon and its mechanisms were known in the carotid artery stenting procedure. To the best of our knowledge, this is the first report of cardiac arrest induced by a carotid sinus reflex during PED deployment. It is important for an operator of PED deployment to recognize its possibility. Vital signs should be closely checked during PED deployment, particularly while pushing the catheter.

    DOI: 10.1016/j.wneu.2018.12.136

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  52. Intraoperative evaluation of local cerebral hemodynamic change by indocyanine green videoangiography: prediction of incidence and duration of postoperative transient neurological events in patients with moyamoya disease 国際誌

    Uda Kenji, Araki Yoshio, Muraoka Shinsuke, Ota Shinji, Wada Kentaro, Yokoyama Kinya, Nishihori Masahiro, Izumi Takashi, Okamoto Sho, Wakabayashi Toshihiko

    JOURNAL OF NEUROSURGERY   130 巻 ( 4 ) 頁: 1367 - 1375   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Neurosurgery  

    OBJECTIVE Transient neurological events (TNEs) occur frequently in the acute phase after direct bypass surgery for moyamoya disease (MMD), but there is currently no way to predict them. FlowInsight is a specialized software for analyzing indocyanine green (ICG) videoangiography taken with a surgical microscope. The purpose of this study was to investigate whether intraoperative evaluation of local hemodynamic changes around anastomotic sites using FlowInsight could predict the incidence and duration of TNEs. METHODS From patients who were diagnosed with MMD in our hospital between August 2014 and March 2017 and who underwent superficial temporal artery–middle cerebral artery bypass surgery, we investigated 25 hemispheres (in 22 patients) in which intraoperative ICG analysis was performed using FlowInsight. To evaluate the local cerebral hemodynamics before and after anastomosis, regions of interest were set at 3 locations on the brain surface around the anastomotic site, and the mean cerebral blood flow (CBF), mean gradation (Grad), mean transit time (MTT), and mean time to peak (TTP) were calculated from the 3 regions of interest. Furthermore, the change rate in CBF (DCBF [%]) was calculated using the formula (postanastomosis mean CBF - preanastomosis mean CBF)/preanastomosis mean CBF. DGrad (%), DMTT (%), and DTTP (%) were similarly calculated. RESULTS Postoperative stroke without TNE occurred in 2 of the 25 hemispheres. These 2 hemispheres (in 2 patients) were excluded from the study, and data from the remaining 23 hemispheres (in 20 patients) were analyzed. For each parameter (DCBF, DGrad, DMTT, and DTTP) calculated by FlowInsight, the difference between the groups with and without TNEs was significant. The median values for DCBF and DGrad were significantly higher in the TNE group than in the no-TNE group (DCBF 30.13 vs 3.54, p = 0.0106; DGrad 62.05 vs 10.78, p = 0.00435), whereas the median values for DMTT and DTTP were significantly lower in the TNE group (DMTT -16.90 vs -7.393, p = 0.023; DTTP -29.07 vs -7.02, p = 0.00342). Comparison of the area under the curve (AUC) for each parameter showed that DTTP had the highest AUC and was the parameter with the highest diagnostic accuracy (AUC 0.857). The Youden index revealed that the optimal cutoff value of DTTP was -11.61 (sensitivity 77.8%, specificity 71.4%) as a predictor of TNEs. In addition, Spearman’s rank correlation coefficients were calculated, and DCBF, DGrad, DMTT, and DTTP each showed a strong correlation with the duration of TNEs. The larger the change in each parameter, the longer the TNEs persisted. CONCLUSIONS Intraoperative ICG videoangiography findings were correlated with the occurrence and duration of TNEs after direct bypass surgery for MMD. Screening for cases at high risk of TNEs can be achieved by ICG analysis using FlowInsight.

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  53. Experimental study of the characteristics of various types of filling coils for intracranial aneurysm embolisation

    Ito Masashi, Matsubara Noriaki, Izumi Takashi, Miyachi Shigeru, Ota Keisuke, Imai Tasuku, Nishihori Masahiro, Wakabayashi Toshihiko

    INTERVENTIONAL NEURORADIOLOGY   24 巻 ( 5 ) 頁: 513 - 519   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Interventional Neuroradiology  

    Background: In endovascular embolisation for an intracranial aneurysm, after framing coil deployment, soft coils (often called filling coils) are usually selected to fill inside the cage of previous coils. Various kinds of filling coils are available, although each coil has its own characteristics. Understanding their differences to ensure proper coil selection is important to achieve successful embolisation. The purpose of this study was to investigate the characteristics of various filling coils. Materials and methods: The authors developed a radiolucent coil to evaluate the performance of coils under conditions simulating the course of embolisation. Experimental embolisation was performed by using a silicone aneurysm filled with radiolucent coils. Indices including area, circularity, centroid position and coefficient of variation were investigated by analysing the figures of the filling coils after being inserted into the radiolucent coil under fluoroscopy. Results: The characteristics of each coil depended on the coil design. The helical coil had the highest circularity and centroid position scores and lowest area score. Therefore, it tended to develop a compacted mass. The low shape-memory coil had the lowest circularity, second-highest centroid position and highest coefficient of variation scores. Therefore, it tended to develop irregularly shaped distribution with low reproducibility. Complex coils generally had higher area and circularity scores. Therefore, they tended to provide a balanced distribution with relatively expanded mass and less small compartmentation. Conclusions: The evaluated characteristics of various filling coils should be useful for appropriate selection of filling coils.

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  54. Association between CYP2C19 genotype and the additional effect of cilostazol to clopidogrel resistance in neuroendovascular therapy

    Tajima Hayato, Izumi Takashi, Miyachi Shigeru, Matsubara Noriaki, Ito Masashi, Imai Tasuku, Nishihori Masahiro, Shintai Kazunori, Okamoto Sho, Araki Yoshio, Kumakura Yasuo, Furukawa-Hibi Yoko, Yamada Kiyofumi, Wakabayashi Toshihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   80 巻 ( 2 ) 頁: 207-215   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18999/nagims.80.2.207

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  55. Association between CYP2C19 genotype and the additional effect of cilostazol to clopidogrel resistance in neuroendovascular therapy.

    Tajima H, Izumi T, Miyachi S, Matsubara N, Ito M, Imai T, Nishihori M, Shintai K, Okamoto S, Araki Y, Kumakura Y, Furukawa-Hibi Y, Yamada K, Wakabayashi T

    Nagoya journal of medical science   80 巻 ( 2 ) 頁: 207 - 215   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya Journal of Medical Science  

    We investigated the association between CYP2C19 genotype and additional effect of cilostazol on clopidogrel resistance (CR) in neuroendovascular therapy. Between January 2012 and January 2016, 447 consecutive patients were administered with 75-mg cilostazol/day. The VerifyNow System was used for evaluating P2Y12 reaction units (PRU) > 230 and/or percentage inhibition of platelet function (% Inhibition) ≤ 20 as CR. Among 158 patients with CR, 31 were administered with additional 100- or 200-mg cilostazol/day and their platelet function was evaluated. According to CYP2C19 genotypes revealed using the Spartan RX and DNeasy Blood & Tissue Kit, patients were classified into three phenotypic groups: extensive metabolizer (EM, three patients), intermediate metabolizer (IM, 12 patients), and poor metabolizer (PM, 16 patients). Administration of additional cilostazol decreased PRU (EM group: 160.7 ± 85.2 after vs 278.3 ± 40.1 before, P = 0.15; IM group: 205.6 ± 74.0 vs 254.3 ± 35.0, P = 0.02; and PM group: 227.8 ± 52.2 vs 282.1 ± 30.4, P = 0.003), and increased % Inhibition (EM group: 40.0 ± 27.9 vs 9.3 ± 3.8, P = 0.25; IM group: 31.4 ± 18.0 vs 11.8 ± 8.2, P = 0.001; and PM group: 24.6 ± 15.0 vs 10.4 ± 9.3, P = 0.001). However, the rate of normalized-clopidogrel response, thromboembolic lesions, and bleeding complications were not significantly different among the three groups. Thus, the addition of cilostazol was effective on CR in terms of PRU, % Inhibition, rate of change of normalized-clopidogrel response, thromboembolic events, and bleeding complications irrespective of phenotype.

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  56. Evaluation for shunted pouches of cavernous sinus dural arteriovenous fistula and the treatment outcome of transvenous embolization

    Sato Masaki, Izumi Takashi, Matsubara Noriaki, Nishihori Masahiro, Miyachi Shigeru, Wakabayashi Toshihiko

    INTERVENTIONAL NEURORADIOLOGY   24 巻 ( 2 ) 頁: 189 - 196   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Interventional Neuroradiology  

    Background: This study aimed to evaluate the detailed location and the number (single or multiple) of cavernous sinus dural arteriovenous fistula (CSDAVF) shunted pouches as well as the relationship between the characteristics of shunted pouch(es) and the treatment outcome of transvenous embolization for CSDAVF. Methods: A total of 23 consecutive patients with CSDAVFs who underwent angiogram and transvenous embolization were retrospectively analyzed. Shunted pouches were assessed using three-dimensional angiogram and multiplanar reformatted image obtained from the rotational angiogram data. Results: Of the 23 patients with CSDAVFs, 40 shunted pouches were identified. Twelve CSDAVFs had a single shunted pouch, and 11 had multiple shunted pouches. The mean CSDAVF with multiple shunted pouches was 2.5. The shunted pouches were more often found in the posterior compartment of the CS, which was connected with the intercavernous sinus (23/40; 57.5%). In 12 CSDAVFs with a single shunted pouch, 10 were treated with selective embolization and complete occlusion was achieved during the follow-up. Two CSDAVFs with single shunted pouch were just observed without intervention, and DAVFs disappeared spontaneously during the follow-up period. In 11 CSDAVFs with multiple shunted pouches, eight were treated with selective embolization and three with sinus embolization. In six of eight (75%), complete occlusion was achieved following selective embolization, but two of eight (25%) recurred and required retreatment. Conclusions: Rotational angiography data suggested that the shunted pouches of CSDAVFs were mostly located in the posterior compartment of the CS connected with the intercavernous sinus. Selective embolization for CSDAVFs with a single shunted pouch is the first-line treatment alternative to sinus packing, and selective embolization with multiple shunted pouches will be a considerable treatment option.

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  57. もやもや病に対する間接血行再建術後における皮質および脳溝内のFLAIR高信号と術後一過性神経脱落症状との関連

    荒木 芳生, 岡本 奨, 横山 欣也, 太田 慎次, 宇田 憲司, 村岡 真輔, 金森 史哲, 西堀 正洋, 泉 孝嗣, 若林 俊彦

    脳卒中の外科   46 巻 ( 6 ) 頁: 439 - 444   2018年

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    記述言語:日本語   出版者・発行元:一般社団法人 日本脳卒中の外科学会  

    DOI: 10.2335/scs.46.439

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  58. Clinical Application of Insertion Force Sensor System for Coil Embolization of Intracranial Aneurysms

    Matsubara Noriaki, Miyachi Shigeru, Izumi Takashi, Yamada Hiroyuki, Marui Naoki, Ota Keisuke, Tajima Hayato, Shintai Kazunori, Ito Masashi, Imai Tasuku, Nishihori Masahiro, Wakabayashi Toshihiko

    WORLD NEUROSURGERY   105 巻   頁: 857 - 863   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:World Neurosurgery  

    Introduction In endovascular embolization for intracranial aneurysms, it is important to properly control the coil insertion force. However, the force can only be subjectively detected by the subtle feedback experienced by neurointerventionists at their fingertips. The authors envisioned a system that would objectively sense and quantify that force. In this article, coil insertion force was measured in cases of intracranial aneurysm using this sensor, and its actual clinical application was investigated. Methods The sensor consists of a hemostatic valve (Y-connector). A little flexure was intentionally added in the device, and it creates a bend in the delivery wire. The sensor measures the change in the position of the bent wire depending on the insertion force and translates it into a force value. Using this, embolization was performed for 10 unruptured intracranial aneurysms. Results The sensor adequately recorded the force, and it reflected the operators' usual clinical experience. The presence of the sensor did not affect the procedures. The sensor enabled the operators to objectively note and evaluate the insertion force and better cooperative handling was possible. Additionally, other members of the intervention team shared the information. Force records demonstrated the characteristic patterns according to every stage of coiling (framing, filling, and finishing). Conclusions The force sensor system adequately measured coil insertion force in intracranial aneurysm coil embolization procedures. The safety of this sensor was demonstrated in clinical application for the limited number of patients. This system is useful adjunct for assisting during coil embolization for an intracranial aneurysm.

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  59. Coiling of a Ruptured Large Internal Carotid Artery Aneurysm via Extracranial-Intracranial Saphenous Vein Bypass Graft Just After Proximal Ligation of the Internal Carotid Artery

    Tajima Hayato, Araki Yoshio, Izumi Takashi, Nishihori Masahiro, Okamoto Sho, Wakabayashi Toshihiko

    WORLD NEUROSURGERY   98 巻   頁: 879.e1 - 879.e4   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:World Neurosurgery  

    Background Combined direct and endovascular surgery has been performed to treat large to giant internal carotid artery (ICA) aneurysms. This report describes successful treatment of a large ICA aneurysm by coiling of the aneurysm via an extracranial-intracranial saphenous vein (SV) graft just after bypass and ICA proximal ligation. Case Description A 66-year-old woman presented with a left ICA supraclinoid aneurysm with progressive visual field defect and impaired visual acuity in the left eye. While waiting for scheduled surgery, she experienced a subarachnoid hemorrhage. An extracranial-intracranial high-flow bypass using an SV graft and proximal ligation of the ICA were performed. Coiling of the aneurysm was immediately performed successfully via the SV bypass graft. The patient experienced no new neurologic deficit after this treatment. Follow-up radiologic evaluations using magnetic resonance imaging and magnetic resonance angiography revealed complete aneurysm occlusion. Conclusions Aneurysm coiling via an extracranial-intracranial SV bypass graft could offer an alternative when an antegrade access route to the ICA is not used because of prior parent artery ligation.

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  60. A Case of Lateral Medullary Artery Arisen from the Posterior Meningeal Artery

    Ito Masashi, Izumi Takashi, Nishihori Masahiro, Imai Tasuku, Tamari Yousuke, Tsukada Tetsuya, Ishida Mamoru, Kropp Asuka, Wakabayashi Toshihiko

    脳神経血管内治療   11 巻 ( 12 ) 頁: 615 - 618   2017年

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    記述言語:英語   出版者・発行元:特定非営利活動法人 日本脳神経血管内治療学会  

    <p><b>Objective:</b> We encountered a patient with lateral medullary infarction during transarterial embolization of the posterior meningeal artery (PMA). We reviewed the anatomic characteristics/imaging findings of this disorder.</p><p><b>Case Presentation:</b> A 69-year-old male. Cerebral infarction involving the lateral medulla occurred during transarterial embolization of a dural arteriovenous fistula. It was considered to be a complication related to occlusion of a lateral medulla-penetrating vessel on microcatheter/guidewire operations in the PMA. When examining images in detail, the blood vessel could be confirmed using DSA and 3D angiography.</p><p><b>Conclusion:</b> When performing embolization, the presence of a brainstem-penetrating vessel originating from the PMA must be considered.</p>

    DOI: 10.5797/jnet.cr.2017-0038

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  61. The Treatment Outcome of Transarterial Embolization for Isolated Sinus Type Dural Arteriovenous Fistula between NBCA and Onyx

    Imai Tasuku, Izumi Takashi, Matsubara Noriaki, Nishihori Masahiro, Ito Masashi, Sato Masaki, Tamari Yosuke, Ishida Mamoru, Tsukada Tetsuya, Miyachi Shigeru, Wakabayashi Toshihiko

    Journal of Neuroendovascular Therapy   11 巻 ( 6 ) 頁: 279 - 287   2017年

     詳細を見る

    記述言語:英語   出版者・発行元:The Japanese Society for Neuroendovascular Therapy  

    <p><b>Objective:</b> The purpose of this study was to compare the clinical outcome of transarterial embolization for isolated sinus type dural arteriovenous fistula (iDAVF) using n-butyl-cyanoacrylate (NBCA) and Onyx.</p><p><b>Methods:</b> Seventeen lesions of iDAVF in 17 patients who underwent transarterial embolization between March 2008 and February 2015 were retrospectively analyzed. They were treated by embolization using NBCA in 10 patients, Onyx in 5 patients, and combination of NBCA and Onyx in 2 patients. We compared the results between embolization with NBCA and Onyx as follows: complete occlusion rate, number of embolized vessels, procedure-related complications, treatment time, dose of radiation exposure, amount of contrast agent, and total cost of the devices.</p><p><b>Results:</b> The complete occlusion rate of iDAVF was significantly higher in the Onyx group: 4 of 10 (40%) in NBCA and 5 of 5 (100%) in Onyx (P = 0.04). The number of treated vessels (5.1 ± 1.2 in NBCA, 1 in Onyx [P <0.001]), the maximum skin entrance dose (NBCA: 5030 ± 1646 [mGy], Onyx: 1670 ± 564 [mGy] in Onyx [P <0.01]), and total cost of the devices (601,265 ± 15,749 [yen] in NBCA, 374,210 ± 122,142 [yen] in Onyx [P <0.01]) were significantly higher in the NBCA. No significant difference was observed in the treatment time and contrast agent dose.</p><p><b>Conclusion:</b> In transarterial embolization of iDAVF, a higher complete occlusion rate was obtained with Onyx, which was also advantageous for reducing the exposure dose and cost of the devices.</p>

    DOI: 10.5797/jnet.oa.2016-0090

    CiNii Research

  62. 詳細な画像診断が治療戦略を決定するうえで有用であった破裂血豆状内頸動脈瘤の1 例

    西堀 正洋, 泉 孝嗣, 松原 功明, 宇田 憲司, 新帯 一憲, 田島 隼人, 伊藤 真史, 今井 資, 若林 俊彦

    脳卒中   39 巻 ( 1 ) 頁: 24 - 28   2017年

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    記述言語:日本語   出版者・発行元:一般社団法人 日本脳卒中学会  

    38 歳女性.頭痛発症のくも膜下出血で受診した.急性期に動脈瘤を認めず,第14 病日の血管撮影で右内頸動脈にわずかな隆起性変化を認め,血豆状内頸動脈瘤が疑われた.MRI CISS 画像とCTA のMPR 画像を比較したところ,拡張部の前後に偽腔が広がり,近位側は眼動脈分岐部の内頸動脈後壁に及んでいると推測された.バルーン閉塞試験にて内頸動脈の遮断耐性は認められたが,眼窩内の血管が全く描出されなかったため,眼動脈を含む内頸動脈病変に対するtrapping は視力障害のリスクが非常に高いと考えられた.治療戦略をステント支援下コイル塞栓術とし,眼動脈を温存した.術後,視力障害を含めた神経症状はなく,動脈瘤の再発もなく経過良好である.本症例では,MRI や血管撮影の詳細な読影を行うことで,治療方針の決定のみならず,合併症リスクも回避することができた.

    DOI: 10.3995/jstroke.10412

    CiNii Research

  63. Treatment protocol based on assessment of clot quality during endovascular thrombectomy for acute ischemic stroke using the Trevo stent retriever 査読有り

    Kojiro Ishikawa, Tomotaka Ohshima, Masahiro Nishihori, Tasuku Imai, Shunsaku Goto, Taiki Yamamoto, Toshihisa Nishizawa, Shinji Shimato, Kyozo Kato

    NAGOYA JOURNAL OF MEDICAL SCIENCE   78 巻 ( 3 ) 頁: 255 - 265   2016年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NAGOYA UNIV, SCH MED  

    The optional endovascular approach for acute ischemic stroke is unclear. The Trevo stent retriever can be used as first-line treatment for fast mechanical recanalization. The authors developed a treatment protocol for acute ischemic stroke based on the assessment of clot quality during clot removal with the Trevo. This prospective single-center study included all patients admitted for acute ischemic stroke between July 2014 and February 2015, who underwent emergency endovascular treatment. According to the protocol, the Trevo was used for first-line treatment. Immediately after the Trevo was deployed, the stent delivery wire was pushed to open the stent by force (ACAPT technique). Clot quality was assessed on the basis of the perfusion status after deployment of the Trevo; continued occlusion or immediate reopening either reoccluded or maintained after the stent retriever had been in place for 5 min. If there was no obvious clot removal after the first pass with the Trevo, according to the quality of the clot, either a second pass was performed or another endovascular device was selected. Twelve consecutive patients with acute major cerebral artery occlusion were analyzed. Thrombolysis in cerebral infarction score 2b and 3 was achieved in 11 patients (91.7%) and 9 (75%) had a good clinical outcome after 90 days based on a modified Rankin scale score &lt;= 2. Symptomatic intracranial hemorrhage occurred in 1 patient (8.3%). The overall mortality rate was 8.3%. Endovascular thrombectomy using the Trevo stent retriever for first-line treatment is feasible and effective.

    Web of Science

  64. Overlap stenting for in-stent restenosis after carotid artery stenting 査読有り

    Nishihori Masahiro, Ohshima Tomotaka, Yamamoto Taiki, Goto Shunsaku, Nishizawa Toshihisa, Shimato Shinji, Izumi Takashi, Kato Kyozo

    NAGOYA JOURNAL OF MEDICAL SCIENCE   78 巻 ( 2 ) 頁: 143 - 149   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  65. Overlap stenting for in-stent restenosis after carotid artery stenting

    Nishihori Masahiro, Ohshima Tomotaka, Yamamoto Taiki, Goto Shunsaku, Nishizawa Toshihisa, Shimato Shinji, Izumi Takashi, Kato Kyozo

    Nagoya Journal of Medical Science   78 巻 ( 2 ) 頁: 143 - 149   2016年5月

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    記述言語:英語   出版者・発行元:Nagoya University Graduate School of Medicine, School of Medicine  

    DOI: 10.18999/nagjms.78.2.143

  66. Overlap stenting for in-stent restenosis after carotid artery stenting.

    Nishihori M, Ohshima T, Yamamoto T, Goto S, Nishizawa T, Shimato S, Izumi T, Kato K

    Nagoya journal of medical science   78 巻 ( 2 ) 頁: 143 - 9   2016年5月

     詳細を見る

    記述言語:英語  

    PubMed

  67. Comparison of Clinical Outcomes Using 10 Coil Versus 14 Coil in Endovascular Coil Embolization for Small and Medium-sized Intracranial Aneurysms: Efficacy of 14 Coil

    Imai Tasuku, Ohshima Tomotaka, Goto Shunsaku, Yamamoto Taiki, Shimato Shinji, Nishizawa Toshihisa, Kato Kyozo, Nishihori Masahiro, Izumi Takashi, Wakabayashi Toshihiko

    脳神経血管内治療   10 巻 ( 4 ) 頁: 196 - 200   2016年

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    記述言語:英語   出版者・発行元:特定非営利活動法人 日本脳神経血管内治療学会  

    <p><b>Objective:</b> The purpose of this retrospective study was to compare the therapeutic results of middle-sized or small cerebral aneurysms coiling using 10 coil (thickness, 0.0095 inch–0.012 inch) and 14 coil (thickness, 0.0135 inch) as a complex framing coil.</p><p><b>Methods:</b> Fifty aneurysms (maximum size, 4 mm–10 mm) in 50 patients treated in our hospital between May 2012 and May 2015 were assigned in this study. We compared the volume embolization rate, recurrence rate, initial occlusion grade between 14 coil (25 aneurysms) and 10 coil (25 aneurysms).</p><p><b>Results:</b> The mean volume embolization ratio was significantly higher (14 coil 37.5 ± 8.8%, 10 coil 32.6 ± 8.4%; P <0.05) in aneurysms coiled with 14 inch coil than those coiled with 10 inch coil. Fourteen inch coil has a higher initial occlusion grade, and lower recurrence rate than 10 coil, but these differences were not significant.</p><p><b>Conclusion:</b> The use of 14 inch framing coil to embolize middle-sized or small cerebral aneurysms is more effective in terms of a higher packing ratio.</p>

    DOI: 10.5797/jnet.oa.2016-0045

    CiNii Books

    その他リンク: http://search.jamas.or.jp/link/ui/2017210157

  68. Multimodal Assessment for Balloon Test Occlusion of the Internal Carotid Artery

    Matsubara Noriaki, Izumi Takashi, Okamoto Sho, Araki Yoshio, Shintai Kazunori, Tajima Hayato, Imai Tasuku, Ito Masashi, Nishihori Masahiro, Miyachi Shigeru, Wakabayashi Toshihiko

    Journal of Neuroendovascular Therapy   10 巻 ( 3 ) 頁: 108 - 115   2016年

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    記述言語:英語   出版者・発行元:The Japanese Society for Neuroendovascular Therapy  

    <b>Objective:</b> Permanent therapeutic occlusion of the carotid artery is one of the treatment options for patients with a large/giant internal carotid artery aneurysm or tumor involving the neck or skull base. Balloon test occlusion (BTO) is performed to predict the tolerance of parent artery occlusion (PAO). The authors combined various modalities to improve the sensitivity of BTO. The purpose of this study is to present the efficacy of the multimodal BTO.<b>Methods:</b> Between January 2008 and September 2014, a total of 50 patients (internal carotid aneurysms: 39, neck or skull base tumor: 8, others: 3; mean 58.4 years, range 7–81 years; 10 men and 40 women) underwent multimodal BTO. Tolerance of PAO was evaluated by the algorithm with various assessment modalities including neurological symptoms with/without induced hypotension, findings of angiogram (collateral flow, venous phase laterality), perfusion CT, and stump pressure. Clinical data of patients with BTO were analyzed retrospectively. Procedures were performed in the angio/CT combination suite. BTO was performed in the usual fashion and when the patient passed the immediate test occlusion, perfusion CT was performed. Subsequently, the angiogram under balloon inflation followed. If the patient did not show neurological symptoms for 20 min, hypotension was induced by intravenous injection of the vasodilator. Neurological symptoms were then checked for more than 30 min.<b>Results:</b> By multimodal assessment of BTO, 33 patients were considered tolerable, six were partially tolerable, and 11 were intolerable. Thirteen of 33 patients with predictive tolerance underwent PAO without bypass, and all but one showed no hemodynamic ischemia postoperatively. Three of six patients with predictive partial tolerance were treated by PAO with extracranial-intracranial bypass, and they experienced no hemodynamic ischemia. In contrast, one with predictive partial tolerance treated by PAO without bypass developed ischemic events as feared.<b>Conclusions:</b> The multimodal BTO is helpful to evaluate the tolerance of PAO and is a reliable predictor of postoperative ischemic events. It reduces risks and increases treatment safety for permanent therapeutic occlusion of the carotid artery.

    DOI: 10.5797/jnet.oa.2015-0012

    CiNii Research

  69. Comparison of Clinical Outcomes Using 10 Coil Versus 14 Coil in Endovascular Coil Embolization for Small and Medium-sized Intracranial Aneurysms: Efficacy of 14 Coil

    Imai Tasuku, Ohshima Tomotaka, Goto Shunsaku, Yamamoto Taiki, Shimato Shinji, Nishizawa Toshihisa, Kato Kyozo, Nishihori Masahiro, Izumi Takashi, Wakabayashi Toshihiko

    Journal of Neuroendovascular Therapy   10 巻 ( 4 ) 頁: 196 - 200   2016年

     詳細を見る

    記述言語:英語   出版者・発行元:The Japanese Society for Neuroendovascular Therapy  

    <p><b>Objective:</b> The purpose of this retrospective study was to compare the therapeutic results of middle-sized or small cerebral aneurysms coiling using 10 coil (thickness, 0.0095 inch–0.012 inch) and 14 coil (thickness, 0.0135 inch) as a complex framing coil.</p><p><b>Methods:</b> Fifty aneurysms (maximum size, 4 mm–10 mm) in 50 patients treated in our hospital between May 2012 and May 2015 were assigned in this study. We compared the volume embolization rate, recurrence rate, initial occlusion grade between 14 coil (25 aneurysms) and 10 coil (25 aneurysms).</p><p><b>Results:</b> The mean volume embolization ratio was significantly higher (14 coil 37.5 ± 8.8%, 10 coil 32.6 ± 8.4%; P <0.05) in aneurysms coiled with 14 inch coil than those coiled with 10 inch coil. Fourteen inch coil has a higher initial occlusion grade, and lower recurrence rate than 10 coil, but these differences were not significant.</p><p><b>Conclusion:</b> The use of 14 inch framing coil to embolize middle-sized or small cerebral aneurysms is more effective in terms of a higher packing ratio.</p>

    DOI: 10.5797/jnet.oa.2016-0045

    CiNii Research

  70. Overlap stenting for in-stent restenosis after carotid artery stenting

    Nishihori M., Ohshima T., Yamamoto T., Goto S., Nishizawa T., Shimato S., Izumi T., Kato K.

    Nagoya Journal of Medical Science   78 巻 ( 2 ) 頁: 143 - 149   2016年

     詳細を見る

    出版者・発行元:Nagoya Journal of Medical Science  

    Our aim was to assess the clinical safety and efficacy of overlap stenting for in-stent restenosis after carotid artery stenting. The study was conducted between July 2008 and February 2015. A database of consecutive carotid artery stenting procedures was retrospectively assessed to identify the cases of in-stent restenosis that were treated with overlap stenting under proximal or distal protection. The clinical and radiological records of the patients were then reviewed. Of the 155 CAS procedures in 149 patients from the database, 6 patients met the inclusion criteria. All the 6 patients were initially treated with moderate dilatation because of the presence of an unstable plaque. The technical success rate of the overlap stenting was 100%, with no 30-day mortality or morbidity. In addition, there was no further in-stent restenosis during a follow-up period of over 12 months. These results indicated that overlap stenting for in-stent restenosis after carotid artery stenting was both safe and effective in our cohort.

    Scopus

  71. 自己拡張型ステント留置後血管は直達術時に安全に遮断可能か?

    西堀 正洋, 大島 共貴, 山本 太樹, 後藤 峻作, 島戸 真司, 西澤 俊久, 加藤 恭三

    脳血管内治療   1 巻 ( 1 ) 頁: 1 - 7   2016年

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    記述言語:日本語   出版者・発行元:特定非営利活動法人 日本脳神経血管内治療学会  

    <p>【目的】ステント留置後の頭蓋内血管に対して,直達手術による追加治療が必要となる状況は今後想定されうる.ステント留置血管を,チタンクリップで一時遮断することは安全に可能かin vitro で評価を行った.【方法】シリコンチューブに33%グリセリン溶液を灌流し加圧した.Enterprise VRD,Neuroform,Wingspan を展開後,チタンクリップで遮断し,圧を負荷して遮断部位の溶液漏出を観察した.また遮断解除後のステントをCone-beam CT で観察した.【結果】Enterprise VRD,Neuroform,Wingspan の順に遮断しやすかった.2 本のパーマネントクリップを用いることで180 mmHg までは,全てのステントが遮断可能であった.遮断解除後,ストラットの損傷はいずれも認めなかった.【結論】現在本邦で使用されている自己拡張ステントが留置されている血管に対して,直達手術時に一時的な血流遮断は可能と考えられた.ステント留置血管を遮断する場合は,パーマネントクリップを2 本用いるのが確実である.</p>

    DOI: 10.20626/nkc.oa.2015-0047

    CiNii Research

▼全件表示

書籍等出版物 1

  1. Use of embolization for the treatment of dural arteriovenous fistula

    Izumi T., Nishihori M., Tsukada T., Araki Y., Uda K., Yokoyama K.

    Arteriovenous Malformations of the Brain  2020年5月  ( ISBN:9781536178920

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    Dural arteriovenous fistula (DAVF) is a relatively rare disease, and often develops pulsatile tinnitus. When accompanied by cerebral cortical venous reflux, patients may present with local neurological symptoms. Recently, transarterial embolization using Onyx is often the first-choice treatment for the patients with DAVF. Transvenous embolization for the affected sinus using platinum coils or liquid embolic material, is applied for cavernous sinus DAVF or transverse sinus/sigmoid sinus dural arteriovenous fistula (Borden type II). Since anatomical knowledge required for embolization is not required in the general practice of treating endovascular diseases, physicians treating dAVF must learn the anatomy of the arteries and veins of the head to increase the safety of embolization.

    Scopus

MISC 10

  1. Rare Dilated Collateral Circulation from Accessory Meningeal Artery to Inferolateral Trunk: A Case Report.

    Ikezawa M, Maeda K, Takasu S, Takemoto M, Nishihori M, Choo J, Sago F, Somiya D, Doba K, Ikeda A  

    NMC case report journal10 巻 ( 0 ) 頁: 47 - 50   2023年

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    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    DOI: 10.2176/jns-nmc.2022-0308

    PubMed

    CiNii Research

  2. Dural Arteriovenous Fistula Mimicking a Brain Tumor on Methionine-positron Emission Tomography: A Case Report.

    Hanyu T, Nishihori M, Izumi T, Motomura K, Ohka F, Goto S, Araki Y, Yokoyama K, Uda K, Saito R  

    NMC case report journal9 巻 ( 0 ) 頁: 289 - 294   2022年

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    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    DOI: 10.2176/jns-nmc.2022-0055

    PubMed

    CiNii Research

  3. Anterior Communicating Artery Aneurysm with a Peculiar Angiographic Appearance: A Case Study.

    Otawa M, Izumi T, Nishihori M, Tsukada T, Oshima R, Kawaguchi T, Goto S, Ikezawa M, Kropp AE, Wakabayashi T  

    NMC case report journal8 巻 ( 1 ) 頁: 57 - 61   2021年4月

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    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    DOI: 10.2176/nmccrj.cr.2020-0036

    PubMed

    CiNii Research

  4. Management of Asymptomatic Vertebral Artery Injury Caused by a Cervical Pedicle Screw Malposition: Two Case Reports.

    Otsuka T, Izumi T, Nishihori M, Tsukada T, Araki Y, Yokoyama K, Uda K, Goto S, Ikezawa M, Kato N, Nakano M, Saito R  

    NMC case report journal8 巻 ( 1 ) 頁: 713 - 717   2021年

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    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    DOI: 10.2176/nmccrj.cr.2021-0062

    PubMed

    CiNii Research

  5. Levodopa-responsive Parkinsonism Caused by Recurrence of Large Basilar-tip Aneurysm after Stent-assisted Coil Embolization: A Case Report.

    Nishihori M, Izumi T, Tsukada T, Araki Y, Yokoyama K, Uda K, Wakabayashi T  

    NMC case report journal8 巻 ( 1 ) 頁: 107 - 111   2021年

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    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    DOI: 10.2176/nmccrj.cr.2020-0023

    PubMed

    CiNii Research

  6. Coexistence of a Dural Arteriovenous Fistula and Pial Arteriovenous Malformation Sharing a Common Drainer.

    Uda K, Izumi T, Kanamori F, Yokoyama K, Tsukada T, Nishihori M, Shintai K, Okamoto S, Araki Y  

    NMC case report journal8 巻 ( 1 ) 頁: 557 - 563   2021年

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    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    DOI: 10.2176/nmccrj.cr.2020-0349

    PubMed

    CiNii Research

  7. 【血行再建術2:血管吻合術】もやもや病に対する間接血行再建術後における皮質および脳溝内のFLAIR高信号と術後一過性神経脱落症状との関連

    荒木 芳生, 岡本 奨, 横山 欣也, 太田 慎次, 宇田 憲司, 村岡 真輔, 金森 史哲, 西堀 正洋, 泉 孝嗣, 若林 俊彦  

    脳卒中の外科46 巻 ( 6 ) 頁: 439 - 444   2018年11月

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    記述言語:日本語   出版者・発行元:(一社)日本脳卒中の外科学会  

    当科で施行した間接血行再建術後急性期にFLAIR高信号とともに一過性神経脱落症状(TNEs)を生じた症例について後方視的に調査を行い、その病態と画像所見に関して考察した。間接血行再建術を行ったもやもや病症例11例(平均15.8歳)を対象とした。術後MRIでは全例diffusion weighted imageとT2*weighted imageにて急性期脳梗塞および出血性病変は否定された。脳溝内の高信号(CSHI)は10半球(62.5%)にて観察され、術後TNEsは9半球(56.3%)で生じており、CSHIとTNEsには統計学的に有意な相関を認めた。また、直接バイパス術を試みたが急性血栓化によって断念し、間接血行再建術となったのは5半球(31.3%)であったが、その症例においては全例CSHIと術後TNEsが出現していた。全例、TNEsは一過性にて改善し、退院時に神経症状が悪化した症例はなかった。

    J-GLOBAL

  8. 小児・若年「非もやもや」頭蓋内血管狭窄の治療と予後 非もやもや病小児閉塞性脳血管障害の診断と治療

    荒木 芳生, 近藤 五郎, 栗本 路弘, 芝 良樹, 宇田 憲司, 太田 慎次, 村岡 真輔, 金森 史哲, 泉 孝嗣, 西堀 正洋, 岡本 奨, 若林 俊彦  

    The Mt. Fuji Workshop on CVD36 巻   頁: 39 - 45   2018年7月

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    記述言語:日本語   出版者・発行元:(株)にゅーろん社  

    当院で非もやもや病小児閉塞性脳血管障害が疑われた5例(男児2例、女児3例、平均年齢11.4歳)を対象に臨床経過や画像所見、神経学的予後について検討した。その結果、5例とも生来健康で外傷歴や血管危険因子は認めなかった。画像所見では、全例で内頸動脈終末部の狭窄を認めたが、ウイリス動脈輪周囲や基底核にもやもや血管は伴っていなかった。だが、3例(60%)は基底核を中心とする脳梗塞で発症していた。また、脳動脈解離に特徴的な所見を呈する症例はなく、1年以内の水痘ウイルス感染、自己免疫疾患や膠原病、全身性血管病変なども否定的であった。RNF213遺伝子多型は1例のみ陽性であった。脳梗塞を認めた3例では発症後早期にMRA上の狭窄進行がみられたが、それ以外は発症後から改善傾向にあった。最終診察時におけるmodified Rankin Scaleは全例で1以下であった。

    J-GLOBAL

  9. 小児・若年「非もやもや」頭蓋内血管狭窄の治療と予後 非もやもや病小児閉塞性脳血管障害の診断と治療

    荒木 芳生, 近藤 五郎, 栗本 路弘, 芝 良樹, 宇田 憲司, 太田 慎次, 村岡 真輔, 金森 史哲, 泉 孝嗣, 西堀 正洋, 岡本 奨, 若林 俊彦  

    The Mt. Fuji Workshop on CVD36 巻   頁: 39 - 45   2018年7月

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    記述言語:日本語   出版者・発行元:(株)にゅーろん社  

    当院で非もやもや病小児閉塞性脳血管障害が疑われた5例(男児2例、女児3例、平均年齢11.4歳)を対象に臨床経過や画像所見、神経学的予後について検討した。その結果、5例とも生来健康で外傷歴や血管危険因子は認めなかった。画像所見では、全例で内頸動脈終末部の狭窄を認めたが、ウイリス動脈輪周囲や基底核にもやもや血管は伴っていなかった。だが、3例(60%)は基底核を中心とする脳梗塞で発症していた。また、脳動脈解離に特徴的な所見を呈する症例はなく、1年以内の水痘ウイルス感染、自己免疫疾患や膠原病、全身性血管病変なども否定的であった。RNF213遺伝子多型は1例のみ陽性であった。脳梗塞を認めた3例では発症後早期にMRA上の狭窄進行がみられたが、それ以外は発症後から改善傾向にあった。最終診察時におけるmodified Rankin Scaleは全例で1以下であった。

  10. The Treatment Outcome of Transarterial Embolization for Isolated Sinus Type Dural Arteriovenous Fistula between NBCA and Onyx

    Imai Tasuku, Izumi Takashi, Matsubara Noriaki, Nishihori Masahiro, Ito Masashi, Sato Masaki, Tamari Yosuke, Ishida Mamoru, Tsukada Tetsuya, Miyachi Shigeru, Wakabayashi Toshihiko  

    JNET : journal of neuroendovascular therapy : official journal of the Japanese Society for Neuroendovascular Therapy11 巻 ( 6 ) 頁: 279 - 287   2017年6月

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    記述言語:英語   出版者・発行元:The Japanese Society for Neuroendovascular Therapy  

    CiNii Books

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講演・口頭発表等 7

  1. コイル塞栓術の治療戦略とコイル選択

    西堀正洋、泉孝嗣、塚田哲也

    第36回日本脳神経血管内治療学会学術総会  2020年11月19日 

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    開催年月日: 2020年11月

    記述言語:日本語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

    開催地:京都   国名:日本国  

  2. フローダイバーターステントの術後長期経過における動脈瘤収縮に関連する因子の解析  

    西堀正洋、泉孝嗣、塚田哲也、池澤瑞香、後藤峻作、大塚崇史、加藤直毅、中野瑞生、クロップ明日香、若林俊彦

    第36回日本脳神経血管内治療学会学術総会  2020年11月19日 

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    開催年月日: 2020年11月

    記述言語:日本語   会議種別:シンポジウム・ワークショップ パネル(公募)  

    開催地:京都   国名:日本国  

  3. 不安定プラークはCASハイリスクか? 招待有り

    西堀正洋、泉孝嗣、塚田哲也、池澤瑞香、後藤峻作、大塚崇史、加藤直毅、中野瑞生、クロップ明日香、若林俊彦

    第36回日本脳神経血管内治療学会学術総会  2020年11月19日 

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    開催年月日: 2020年11月

    記述言語:日本語   会議種別:口頭発表(一般)  

    開催地:京都  

  4. 頸動脈ステント留置術 (CAS) feel the difference 招待有り

    西堀正洋、泉孝嗣、塚田哲也

    第36回日本脳神経血管内治療学会学術総会  2020年11月19日 

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    開催年月日: 2020年11月

    記述言語:日本語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

    開催地:京都   国名:日本国  

  5. フローダイバーターステントの術後長期経過における動脈瘤収縮に関連する因子の解析  

    西堀正洋、泉孝嗣、塚田哲也、池澤瑞香、後藤峻作、大塚崇史、加藤直毅、中野瑞生、クロップ明日香、若林俊彦

    第79回日本脳神経外科学会総会  2020年10月15日 

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    開催年月日: 2020年10月

    記述言語:日本語   会議種別:シンポジウム・ワークショップ パネル(公募)  

    開催地:第79回日本脳神経外科学会総会   国名:日本国  

  6. 不安定プラークはCASハイリスクか?

    西堀正洋、泉孝嗣、塚田哲也、池澤瑞香、後藤峻作、大塚崇史、加藤直毅、中野瑞生、クロップ明日香、若林俊彦

    第45回日本脳卒中学会学術集会  2020年8月23日 

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    開催年月日: 2020年8月

    記述言語:日本語   会議種別:口頭発表(一般)  

    開催地:横浜   国名:日本国  

  7. 破裂大型内頚動脈瘤に対して段階的血管内治療を行った3例

    西堀正洋、泉孝嗣、塚田哲也、池澤瑞香、後藤峻作、大塚崇史、加藤直毅、中野瑞生、クロップ明日香、若林俊彦

    第45回日本脳卒中学会学術集会   2020年8月23日 

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    開催年月日: 2020年8月

    記述言語:日本語   会議種別:ポスター発表  

    開催地:横浜   国名:日本国  

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科研費 1

  1. 海綿静脈洞部硬膜動静脈瘻と下垂体ホルモンとの因果関係に関する研究

    研究課題/研究課題番号:18K16580  2018年4月 - 2022年3月

    科学研究費助成事業  若手研究

    西堀 正洋

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    担当区分:研究代表者  資金種別:競争的資金

    配分額:1950000円 ( 直接経費:1500000円 、 間接経費:450000円 )

    硬膜動静脈瘻は稀な頭蓋内シャント疾患で頭蓋内の種々の部位に発生するが、部位ごとに男女差を認める。海綿静脈洞(CS)部は他部位に比べ女性が2倍以上男性よりも生じやすい。外傷や炎症など複合的な成因が考えられているが、海綿静脈洞部は脳下垂体と接しており性ホルモンの影響が存在すると推察した。25例に対して血液サンプルを部位別に性ホルモン濃度を測定した。E2とLHは、内頸静脈部と末梢部の間に有意差があった。E2はCS群と横静脈洞部(TS)群でも有意差があった。CS群では内頸静脈部は末梢血より有意に高値であった。LHについては、女性では内頸静脈での採血が末梢と比べて全体的に有意に増加していた。
    本研究は探索的研究である。性ホルモンが海綿静脈洞(CS)内、内頸静脈、末梢でどれほどの違いがあるかということに加えて、性差並びに部位による違いを確認した。EstradiolとLHは、内頸静脈部と末梢部の間に有意差があった。EstradiolはCS群と横静脈洞部(TS)群でも有意差があった。CS群では内頸静脈部は末梢血より有意に高値であった。LHについては、女性では内頸静脈での採血が末梢と比べて全体的に有意に増加していた。FSHならびにProgesteroneでは有意差は認めなかった。本研究結果を踏まえて、さらに硬膜動静脈瘻の成因についての研究を進めていきたいと考えている。

 

担当経験のある科目 (本学) 3

  1. 血管吻合実習

    2020

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    クリニカルシュミレーションセンターにて血管吻合実習を行なう

  2. 脳新規外科 脳血管内治療・画像講義

    2020

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    血管撮影室において、脳血管内治療・脳卒中画像の講義を行なう

  3. PBLチュートリアル

    2020

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    症例ベースでの問題解決型チュートリアル授業

 

学術貢献活動 1

  1. 第46回日本脳卒中学会学術集会

    役割:査読

    九州大学大学院医学研究院病態機能内科学  2021年3月

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    種別:学会・研究会等