Updated on 2022/05/16

写真a

 
NISHIHORI Masahiro
 
Organization
Nagoya University Hospital Neurosurgery Assistant professor of hospital
Title
Assistant professor of hospital
Contact information
メールアドレス
External link

Degree 1

  1. Ph.D. ( 2021.9   Nagoya University ) 

Research Interests 4

  1. 脳動脈瘤

  2. 硬膜動静脈瘻

  3. 医用画像処理

  4. 脳血管内治療

Research Areas 1

  1. Life Science / Neurosurgery

Research History 1

  1. Nagoya University   Nagoya University Hospital Neurosurgery   Assistant professor of hospital

    2016.3

Education 2

  1. Nagoya University

    2013.4 - 2016.2

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    2002.4 - 2008.3

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    Country: Japan

Professional Memberships 6

  1. 日本脳神経外科学会

  2. 日本脳神経血管内治療学会

  3. 日本脳卒中学会

  4. 日本脳卒中の外科学会

  5. 日本脳神経CI学会

  6. 日本脳神経外科コングレス

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Papers 38

  1. Blood flow stagnation after treatment of a giant internal carotid artery aneurysm: a computed fluid dynamics analysis.

    Muraoka S, Takagi R, Araki Y, Uda K, Sumitomo M, Okamoto S, Nishihori M, Izumi T, Nakamura M, Saito R

    Scientific reports   Vol. 12 ( 1 ) page: 7283   2022.5

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    Language:English  

    DOI: 10.1038/s41598-022-11321-6

    PubMed

  2. Medical Management of a Mural Thrombus Inducing Repeated Ischemic Strokes in a Patient with Congenital Afibrinogenemia.

    Nishihori M, Araki Y, Suzuki N, Tamura S, Hattori M, Izumi T, Goto S, Yokoyama K, Uda K, Matsushita T, Saito R

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   Vol. 31 ( 7 ) page: 106526   2022.4

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  3. Challenging direct bypass surgery for very young children with moyamoya disease: technical notes

    Araki Yoshio, Uda Kenji, Yokoyama Kinya, Kanamori Fumiaki, Kurimoto Michihiro, Shiba Yoshiki, Mamiya Takashi, Nishihori Masahiro, Takeuchi Kazuhito, Tanahashi Kuniaki, Nagata Yuichi, Nishimura Yusuke, Okamoto Sho, Sumitomo Masaki, Izumi Takashi, Saito Ryuta

    NEUROSURGICAL REVIEW   Vol. 45 ( 2 ) page: 1799 - 1807   2022.4

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  4. Advantages of petrosectomy for superficial temporal artery to superior cerebellar artery bypass based on three-dimensional distance measurements using cadaver heads

    Uda Kenji, Tanahashi Kuniaki, Mamiya Takashi, Kanamori Fumiaki, Yokoyama Kinya, Nishihori Masahiro, Izumi Takashi, Araki Yoshio, Saito Ryuta

    NEUROSURGICAL REVIEW   Vol. 45 ( 2 ) page: 1617 - 1624   2022.4

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  5. Risk Factors for Cerebral Infarction Early After Revascularization in Children Younger than 5 Years with Moyamoya Disease.

    Araki Y, Uda K, Yokoyama K, Kanamori F, Kurimoto M, Shiba Y, Mamiya T, Nishihori M, Takeuchi K, Tanahashi K, Nagata Y, Nishimura Y, Okamoto S, Sumitomo M, Izumi T, Saito R

    World neurosurgery   Vol. 160   page: e220 - e226   2022.4

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    Language:English  

    DOI: 10.1016/j.wneu.2021.12.115

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  6. Changes in cerebral blood flow in the postoperative chronic phase after combined cerebral revascularization for moyamoya disease with ischaemic onset

    Araki Yoshio, Mamiya Takashi, Fujita Naotoshi, Uda Kenji, Yokoyama Kinya, Kanamori Fumiaki, Takayanagi Kai, Ishii Kazuki, Nishihori Masahiro, Takeuch Kazuhito, Tanahashi Kuniaki, Nagata Yuichi, Nishimura Yusuke, Tanei Takafumi, Sumitomo Masaki, Okamoto Sho, Izumi Takashi, Kato Katsuhiko, Saito Ryuta

    NEUROSURGICAL REVIEW     2022.3

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  7. Postoperative stroke and neurological outcomes in the early phase after revascularization surgeries for moyamoya disease: an age-stratified comparative analysis

    Araki Yoshio, Yokoyama Kinya, Uda Kenji, Kanamori Fumiaki, Kurimoto Michihiro, Shiba Yoshiki, Mamiya Takashi, Nishihori Masahiro, Izumi Takashi, Sumitomo Masaki, Okamoto Sho, Matsui Kota, Emoto Ryo, Wakabayashi Toshihiko, Matsui Shigeyuki, Natsume Atsushi

    NEUROSURGICAL REVIEW   Vol. 44 ( 5 ) page: 2785 - 2795   2021.10

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  8. Triggering of Carotid Sinus Reflex during Deployment the Flow-diverter Device

    Goto Shunsaku, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Araki Yoshio, Uda Kenji, Yokoyama Kinya, Saito Ryuta

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 61 ( 10 ) page: 583 - 590   2021.10

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  9. Evaluation of the differences in pressure applied to the vessel wall by different types of balloon remodeling microcatheters in an experimental model

    Ikezawa Mizuka, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Tamari Yosuke, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Goto Shunsaku, Kropp Asuka E., Otsuka Takafumi, Kato Naoki, Nakano Mizuki, Saito Ryuta

    INTERVENTIONAL NEURORADIOLOGY     page: 15910199211031765   2021.9

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  10. Streak Metal Artifact Reduction Technique in Cone Beam Computed Tomography Images after Endovascular Neurosurgery Reviewed

    Otsuka Takafumi, Nishihori Masahiro, Izumi Takashi, Uemura Takeshi, Sakai Takashi, Nakano Mizuki, Kato Naoki, Kanamori Fumiaki, Tsukada Tetsuya, Uda Kenji, Yokoyama Kinya, Araki Yoshio, Saito Ryuta

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 61 ( 8 ) page: 468 - 474   2021.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmc.oa.2021-0014

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  11. Indocyanine green emission timing of the recipient artery in revascularization surgery for moyamoya disease

    Kanamori Fumiaki, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Mamiya Takashi, Nishihori Masahiro, Izumi Takashi, Okamoto Sho, Natsume Atsushi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 3 ) page: 523 - 534   2021.8

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  12. Evaluation of the Straightening Phenomenon of Various Types of Coils

    Ishida Mamoru, Izumi Takashi, Araki Yoshio, Nishihori Masahiro, Yokoyama Kinya, Uda Kenji, Tsukada Tetsuya, Wakabayashi Toshihiko

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 61 ( 6 ) page: 356 - 360   2021.6

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  13. Effects of aspirin and heparin treatment on perioperative outcomes in patients with Moyamoya disease Reviewed International journal

    Kanamori Fumiaki, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Mamiya Takashi, Nishihori Masahiro, Izumi Takashi, Okamoto Sho, Natsume Atsushi

    ACTA NEUROCHIRURGICA   Vol. 163 ( 5 ) page: 1485 - 1491   2021.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00701-020-04668-0

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  14. Ipsilateral late stroke after revascularization surgery for patients with Moyamoya disease

    Araki Yoshio, Yokoyama Kinya, Uda Kenji, Kanamori Fumiaki, Mamiya Takashi, Nishihori Masahiro, Sumitomo Masaki, Okamoto Sho, Izumi Takashi

    ACTA NEUROCHIRURGICA   Vol. 163 ( 5 ) page: 1493 - 1502   2021.5

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  15. Short-segment Internal Trapping for Symptomatic Thrombosed Large Fusiform Vertebral Artery Aneurysms (Bird's Nest Trapping): A Technical Note Reviewed

    Nishihori Masahiro, Izumi Takashi, Tsukada Tetsuya, Kropp Asuka Elisabeth, Uda Kenji, Yokoyama Kinya, Araki Yoshio, Wakabayashi Toshihiko

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 61 ( 4 ) page: 284 - 291   2021.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmc.tn.2020-0329

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  16. Development and clinical evaluation of a contactless operating interface for three-dimensional image-guided navigation for endovascular neurosurgery Reviewed International journal

    Nishihori Masahiro, Izumi Takashi, Nagano Yoshitaka, Sato Masaki, Tsukada Tetsuya, Kropp Asuka Elisabeth, Wakabayashi Toshihiko

    INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY   Vol. 16 ( 4 ) page: 663 - 671   2021.4

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    Language:Japanese   Publishing type:Doctoral thesis  

    DOI: 10.1007/s11548-021-02330-3

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  17. Anterior Communicating Artery Aneurysm with a Peculiar Angiographic Appearance: A Case Study.

    Otawa M, Izumi T, Nishihori M, Tsukada T, Oshima R, Kawaguchi T, Goto S, Ikezawa M, Kropp AE, Wakabayashi T

    NMC case report journal   Vol. 8 ( 1 ) page: 57 - 61   2021.4

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    Language:English  

    DOI: 10.2176/nmccrj.cr.2020-0036

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  18. Analysis of relationship between superior hypophyseal artery visualization and preservation and postoperative visual field deficit in paraclinoid aneurysm

    Otawa Masato, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Oshima Ryosuke, Kawaguchi Tomomi, Goto Shunsaku, Ikezawa Mizuka, Kropp Asuka Elisabeth, Araki Yoshio, Uda Kenji, Wakabayashi Toshihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 1 ) page: 21 - 30   2021.2

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  19. Direct Vertebral Artery Puncture During Open Surgery for the Endovascular Treatment of a Recurrent Vertebro-Vertebral Arteriovenous Fistula Reviewed

    Ikezawa Mizuka, Izumi Takashi, Nishihori Masahiro, Nagashima Yoshitaka, Nishimura Yusuke, Tsukuda Tetsuya, Kropp Asuka E., Goto Shunsaku, Otsuka Takafumi, Kato Naoki, Nakano Mizuki

    WORLD NEUROSURGERY   Vol. 146   page: 166 - 170   2021.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2020.10.156

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  20. Case-control study of postprocedural arterial puncture site hemorrhage after neuroendovascular treatment Reviewed

    Tamari Yosuke, Izumi Takashi, Nishihori Masahiro, Imai Tasuku, Ito Masashi, Tsukada Tetsuya, Ishida Mamoru, Wakabayashi Toshihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 1 ) page: 125 - 133   2021.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.83.1.125

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  21. Coexistence of a Dural Arteriovenous Fistula and Pial Arteriovenous Malformation Sharing a Common Drainer.

    Uda K, Izumi T, Kanamori F, Yokoyama K, Tsukada T, Nishihori M, Shintai K, Okamoto S, Araki Y

    NMC case report journal   Vol. 8 ( 1 ) page: 557 - 563   2021

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    Language:English  

    DOI: 10.2176/nmccrj.cr.2020-0349

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  22. Management of Asymptomatic Vertebral Artery Injury Caused by a Cervical Pedicle Screw Malposition: Two Case Reports.

    Otsuka T, Izumi T, Nishihori M, Tsukada T, Araki Y, Yokoyama K, Uda K, Goto S, Ikezawa M, Kato N, Nakano M, Saito R

    NMC case report journal   Vol. 8 ( 1 ) page: 713 - 717   2021

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    Language:English  

    DOI: 10.2176/nmccrj.cr.2021-0062

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  23. Levodopa-responsive Parkinsonism Caused by Recurrence of Large Basilar-tip Aneurysm after Stent-assisted Coil Embolization: A Case Report.

    Nishihori M, Izumi T, Tsukada T, Araki Y, Yokoyama K, Uda K, Wakabayashi T

    NMC case report journal   Vol. 8 ( 1 ) page: 107 - 111   2021

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    DOI: 10.2176/nmccrj.cr.2020-0023

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  24. [Ruptured Spinal Arteriovenous Malformation Mimicking Bacterial Meningitis:A Case Report]. Reviewed

    Hiramatsu T, Nishihori M, Haraguchi K, Okada T, Endo O, Fujii K, Yokoyama H, Takayanagi K, Yamamoto N

    No shinkei geka. Neurological surgery   Vol. 48 ( 11 ) page: 1051 - 1057   2020.11

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11477/mf.1436204319

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  25. A case of internal trapping to a thrombosed giant rapidly growing aneurysm at the posterior cerebral artery

    Otawa Masato, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Oshima Ryosuke, Kawaguchi Tomomi, Goto Shunsaku, Ikezawa Mizuka, Kropp Asuka Elisabeth, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Wakabayashi Toshihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 3 ) page: 557 - 566   2020.8

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  26. Surgical Designs of Revascularization for Moyamoya Disease: 15 Years of Experience in a Single Center

    Araki Yoshio, Uda Kenji, Yokoyama Kinya, Kanamori Fumiaki, Mamiya Takashi, Nishihori Masahiro, Izumi Takashi, Tanahashi Kuniaki, Masaki Sumitomo, Sho Okamoto, Wakabayashi Toshihiko, Natsume Atsushi

    WORLD NEUROSURGERY   Vol. 139   page: E325 - E334   2020.7

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  27. Endovascular Therapy for Intracranial Artery Stenosis: Results from the Japanese Registry of Neuroendovascular Therapy (JR-NET)3.

    Izumi T, Nishihori M, Imamura H, Iihara K, Sakai N, JR-NET investigators.

    Neurologia medico-chirurgica   Vol. 60 ( 5 ) page: 256 - 263   2020.5

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    Language:English  

    DOI: 10.2176/nmc.oa.2019-0271

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  28. Comparison of hemodynamic stress in healthy vessels after parent artery occlusion and flow diverter stent treatment for internal carotid artery aneurysm

    Tsukada Tetsuya, Izumi Takashi, Isoda Haruo, Nishihori Masahiro, Kropp A. Elisabeth, Mizuno Takashi, Wakabayashi Toshihiko

    JOURNAL OF NEUROSURGERY   Vol. 136 ( 3 ) page: 619 - 626   2020.3

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  29. Brain Compression by Encephalo-Myo-Synangiosis is a Risk Factor for Transient Neurological Deficits After Surgical Revascularization in Pediatric Patients with Moyamoya Disease Reviewed

    Kanamori Fumiaki, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Nishihori Masahiro, Izumi Takashi, Okamoto Sho, Wakabayashi Toshihiko

    WORLD NEUROSURGERY   Vol. 133   page: E558 - E566   2020.1

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  30. Factors influencing blood flow resistance from a large internal carotid artery aneurysm revealed by a computational fluid dynamics model

    Imai Tasuku, Izumi Takashi, Isoda Haruo, Ishiguro Kenta, Mizuno Takashi, Tsukada Tetsuya, Kropp Asuka, Ito Masashi, Nishihori Masahiro, Ishida Mamoru, Tamari Yosuke, Wakabayashi Toshihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 4 ) page: 629 - 636   2019.11

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  31. Cardiac arrest induced by carotid sinus reflex activation during flow-diverter stent deployment.

    Goto S, Izumi T, Nishihori M, Ishida M, Ishida T, Otawa M, Kawaguchi T, Oshima R, Kropp A, Ikezawa M, Wakabayashi T

    World neurosurgery   Vol. 124   page: 22 - 24   2019.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2018.12.136

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  32. Intraoperative evaluation of local cerebral hemodynamic change by indocyanine green videoangiography: prediction of incidence and duration of postoperative transient neurological events in patients with moyamoya disease.

    Uda K, Araki Y, Muraoka S, Ota S, Wada K, Yokoyama K, Nishihori M, Izumi T, Okamoto S, Wakabayashi T

    Journal of neurosurgery   Vol. 130 ( 4 ) page: 1367 - 1375   2019.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3171/2017.10.JNS171523

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  33. Experimental study of the characteristics of various types of filling coils for intracranial aneurysm embolisation

    Ito Masashi, Matsubara Noriaki, Izumi Takashi, Miyachi Shigeru, Ota Keisuke, Imai Tasuku, Nishihori Masahiro, Wakabayashi Toshihiko

    INTERVENTIONAL NEURORADIOLOGY   Vol. 24 ( 5 ) page: 513-519   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1591019918779196

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  34. Association between CYP2C19 genotype and the additional effect of cilostazol to clopidogrel resistance in neuroendovascular therapy

    Tajima Hayato, Izumi Takashi, Miyachi Shigeru, Matsubara Noriaki, Ito Masashi, Imai Tasuku, Nishihori Masahiro, Shintai Kazunori, Okamoto Sho, Araki Yoshio, Kumakura Yasuo, Furukawa-Hibi Yoko, Yamada Kiyofumi, Wakabayashi Toshihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 2 ) page: 207-215   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagims.80.2.207

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  35. Association between CYP2C19 genotype and the additional effect of cilostazol to clopidogrel resistance in neuroendovascular therapy.

    Tajima H, Izumi T, Miyachi S, Matsubara N, Ito M, Imai T, Nishihori M, Shintai K, Okamoto S, Araki Y, Kumakura Y, Furukawa-Hibi Y, Yamada K, Wakabayashi T

    Nagoya journal of medical science   Vol. 80 ( 2 ) page: 207-215   2018.5

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    DOI: 10.18999/nagjms.80.2.207

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  36. Evaluation for shunted pouches of cavernous sinus dural arteriovenous fistula and the treatment outcome of transvenous embolization.

    Sato M, Izumi T, Matsubara N, Nishihori M, Miyachi S, Wakabayashi T

    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences   Vol. 24 ( 2 ) page: 189 - 196   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1591019917743064

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  37. Clinical Application of Insertion Force Sensor System for Coil Embolization of Intracranial Aneurysms

    Matsubara Noriaki, Miyachi Shigeru, Izumi Takashi, Yamada Hiroyuki, Marui Naoki, Ota Keisuke, Tajima Hayato, Shintai Kazunori, Ito Masashi, Imai Tasuku, Nishihori Masahiro, Wakabayashi Toshihiko

    WORLD NEUROSURGERY   Vol. 105   page: 857-863   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2017.06.092

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  38. Coiling of a Ruptured Large Internal Carotid Artery Aneurysm via Extracranial-Intracranial Saphenous Vein Bypass Graft Just After Proximal Ligation of the Internal Carotid Artery

    Tajima Hayato, Araki Yoshio, Izumi Takashi, Nishihori Masahiro, Okamoto Sho, Wakabayashi Toshihiko

    WORLD NEUROSURGERY   Vol. 98   page: 879.e1-879.e4   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2016.11.066

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Presentations 7

  1. コイル塞栓術の治療戦略とコイル選択

    西堀正洋、泉孝嗣、塚田哲也

    第36回日本脳神経血管内治療学会学術総会  2020.11.19 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:京都   Country:Japan  

  2. フローダイバーターステントの術後長期経過における動脈瘤収縮に関連する因子の解析  

    西堀正洋、泉孝嗣、塚田哲也、池澤瑞香、後藤峻作、大塚崇史、加藤直毅、中野瑞生、クロップ明日香、若林俊彦

    第36回日本脳神経血管内治療学会学術総会  2020.11.19 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  3. 不安定プラークはCASハイリスクか? Invited

    西堀正洋、泉孝嗣、塚田哲也、池澤瑞香、後藤峻作、大塚崇史、加藤直毅、中野瑞生、クロップ明日香、若林俊彦

    第36回日本脳神経血管内治療学会学術総会  2020.11.19 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都  

  4. 頸動脈ステント留置術 (CAS) feel the difference Invited

    西堀正洋、泉孝嗣、塚田哲也

    第36回日本脳神経血管内治療学会学術総会  2020.11.19 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:京都   Country:Japan  

  5. フローダイバーターステントの術後長期経過における動脈瘤収縮に関連する因子の解析  

    西堀正洋、泉孝嗣、塚田哲也、池澤瑞香、後藤峻作、大塚崇史、加藤直毅、中野瑞生、クロップ明日香、若林俊彦

    第79回日本脳神経外科学会総会  2020.10.15 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:第79回日本脳神経外科学会総会   Country:Japan  

  6. 不安定プラークはCASハイリスクか?

    西堀正洋、泉孝嗣、塚田哲也、池澤瑞香、後藤峻作、大塚崇史、加藤直毅、中野瑞生、クロップ明日香、若林俊彦

    第45回日本脳卒中学会学術集会  2020.8.23 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  7. 破裂大型内頚動脈瘤に対して段階的血管内治療を行った3例

    西堀正洋、泉孝嗣、塚田哲也、池澤瑞香、後藤峻作、大塚崇史、加藤直毅、中野瑞生、クロップ明日香、若林俊彦

    第45回日本脳卒中学会学術集会   2020.8.23 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

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KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. 海綿静脈洞部硬膜動静脈瘻と下垂体ホルモンとの因果関係に関する研究

    Grant number:18K16580  2018.4 - 2022.3

    科学研究費助成事業  若手研究

    西堀 正洋

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1950000 ( Direct Cost: \1500000 、 Indirect Cost:\450000 )

    硬膜動静脈瘻は後天的に生じる稀な頭蓋内シャント疾患である。発生部位は頭蓋内の種々の部位があるが、日本における全国調査の結果より、海綿静脈洞部は他の部位に比して2倍以上男性より女性に多い。症状は多彩であり、また診断や治療においては非常に専門的な知識と経験を必要とする疾患である。硬膜動静脈瘻の原因は未だに不明であるが、外傷・骨折・炎症・静脈高血圧など多くの複合的因子が関与する。海綿静脈洞部は脳下垂体に接している静脈洞であり、ここを経由して下垂体ホルモンが血中に分泌されているため、性差を考慮すると、同部位には少なからず性ホルモンの影響があると推察される。その関連を明確に示唆する研究や論文は極めて少ない。
    そのため、この部位における発生要因としての下垂体ホルモンやその周辺因子につき評価および研究を行う。また本研究は実際に多くの硬膜動静脈瘻について治療を行っている施設でなければ成立しづらく、当施設は本疾患において基幹病院であるため研究を進めることができる。性ホルモンとその代謝因子、生活背景の因子(飲酒・喫煙・妊娠分娩歴など)なども合わせて調査する。現在は本学生命倫理委員会へ申請を行うと同時に、機器部門と相談し、性ホルモンの測定についてELISA法を用いて解析を勧めている。同意いただいた症例より血液サンプルを採取し、解析を行った。
    海綿静脈洞部・内頸静脈・末梢で比較すると、明確な差はなかったが、正常値よりも性ホルモンの濃度が高値である症例があった。現在は外来患者などを含めて追加実験を行い、その正当性を追加評価している状況である。
    海綿静脈洞部・横静脈洞部の硬膜動静脈瘻の症例に対して現在までに多くの血液サンプルを得て、ELISA法を中心に解析を行っている。生活背景の因子(飲酒・喫煙・妊娠分娩歴など)なども合わせて調査している。
    現在第一段階の解析は終了し、それを踏まえて母集団を増やし第二段階での解析を進めている。この結果を元に論文作成に至る予定である。
    海綿静脈洞部・横静脈洞部の症例から得たサンプルに対してELISA法にて解析を行っている。
    現在母集団を増やしながら、二次解析中であり、論文化する予定である。

 

Teaching Experience (On-campus) 3

  1. 血管吻合実習

    2020

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    クリニカルシュミレーションセンターにて血管吻合実習を行なう

  2. PBLチュートリアル

    2020

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    症例ベースでの問題解決型チュートリアル授業

  3. 脳新規外科 脳血管内治療・画像講義

    2020

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    血管撮影室において、脳血管内治療・脳卒中画像の講義を行なう

 

Academic Activities 1

  1. The 46th congress of japanese stroke society

    Role(s):Peer review

    2021.3

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    Type:Academic society, research group, etc.