Organization
Institute of Transformative Bio-Molecules Designated professor
Graduate School
Graduate School of Science
Title
Designated professor
TSUCHIYA Yuichiro
Degree 1
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博士（農学） （ 2002.3 北海道大学 ）
Research Interests 4
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ケミカルバイオロジー
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ストリゴラクトン
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寄生植物
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植物ホルモン
Research Areas 1
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Life Science / Plant molecular biology and physiology / 植物ホルモン
Current Research Project and SDGs 1
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寄生植物ストライガの発芽に関する研究
Research History 3
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Nagoya University Institute of Transformative Bio-Molecules Designated professor
2021.4
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Nagoya University Institute of Transformative Bio-Moleucules Designated associate professor Designated associate professor
2015.12 - 2021.3
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Nagoya University Transformative Bio-Molecules / Graduate School of Science Researcher
2013.5 - 2015.11
Education 3
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Hokkaido University Faculty of Agriculture Applied Bioscience
1999.4 - 2002.3
Country： Japan
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Hokkaido University Faculty of Agriculture Applied bioscience
1997.4 - 1999.3
Country： Japan
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Hokkaido University Faculty of Agriculture Applied bioscience
1993.4 - 1997.3
Country： Japan
Papers 7
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Yap, JX; Tsuchiya, Y
PLANT AND CELL PHYSIOLOGY Vol. 64 ( 9 ) page： 1021 - 1033 2023.9
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Ashida, K; Hoshimoto, Y; Tohnai, N; Scott, DE; Ohashi, M; Imaizumi, H; Tsuchiya, Y; Ogoshi, S
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 142 ( 3 ) page： 1594 - 1602 2020.1
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Unravel strigolactone signaling and controlling parasitic plant behaviors
Tsuchiya, Y
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 257 2019.3
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A femtomolar-range suicide germination stimulant for the parasitic plant <i>Striga hermonthica</i>
Uraguchi, D; Kuwata, K; Hijikata, Y; Yamaguchi, R; Imaizumi, H; Sathiyanarayanan, AM; Rakers, C; Mori, N; Akiyama, K; Irle, S; McCourt, P; Kinoshita, T; Ooi, T; Tsuchiya, Y
SCIENCE Vol. 362 ( 6420 ) page： 1301 - + 2018.12
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Small Molecule Toolbox for Strigolactone Biology
Tsuchiya, Y
PLANT AND CELL PHYSIOLOGY Vol. 59 ( 8 ) page： 1511 - 1519 2018.8
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The dynamics of strigolactone perception in <i>Striga hermonthica</i>: a working hypothesis
Tsuchiya, Y; Yoshimura, M; Hagihara, S
JOURNAL OF EXPERIMENTAL BOTANY Vol. 69 ( 9 ) page： 2281 - 2290 2018.4
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Discovery of Shoot Branching Regulator Targeting Strigolactone Receptor DWARF14
Yoshimura, M; Sato, A; Kuwata, K; Inukai, Y; Kinoshita, T; Itami, K; Tsuchiya, Y; Hagihara, S
ACS CENTRAL SCIENCE Vol. 4 ( 2 ) page： 230 - 234 2018.2
Books 1
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Assessing Seed Germination Response of Parasitic Plant Striga hermonthica with Small-Molecule Probes
Yap J.X., Tsuchiya Y.
Methods in Molecular Biology 2024
MISC 1
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Strigolactone receptors in Striga hermonthica Invited Reviewed
Masahiko Yoshimura, Yuichiro Tsuchiya, Yoshikatsu Sato, Kenichiro Itami, Toshinori Kinoshita, Shinya Hagihara
Plant Morphology Vol. 29 ( 1 ) page： 33 - 37 2017
KAKENHI (Grants-in-Aid for Scientific Research) 7
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Grant number：24KK0118 2024.9 - 2028.3
科学研究費助成事業 国際共同研究加速基金(海外連携研究)
土屋 雄一朗
Authorship：Principal investigator
Grant amount：\20800000 （ Direct Cost: \16000000 、 Indirect Cost：\4800000 ）
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Comparative chemical genomic analysis on plant parasitism
Grant number：21H04775 2021.4 - 2026.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
Authorship：Principal investigator
Grant amount：\42120000 （ Direct Cost: \32400000 、 Indirect Cost：\9720000 ）
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Elucidating strigolactone signal transduction using fungal model system
Grant number：20K20569 2020.7 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Pioneering)
Authorship：Principal investigator
Grant amount：\26000000 （ Direct Cost: \20000000 、 Indirect Cost：\6000000 ）
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Grant number：19KK0152 2019.10 - 2024.3
Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
Authorship：Coinvestigator(s)
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Elucidating the mechanism of strigolactone signal transduction in a parasitic plant Striga
Grant number：18H02459 2018.4 - 2021.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Tsuchiya Yuichiro
Authorship：Principal investigator
Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）
A parasitic plant called Striga causes huge damages on crop production in Africa by parasitizing monocot crops including maize and sorghum. Dormant Striga seeds sense host-derived strigolactones (SLs) for germination. We took chemical genetic approach to identify novel components involved in this process. We performed two types of chemical screening, one for suppressors of SL-induced germination, and the other for small molecules that break upper-limit of Striga germination rate. Both screenings identify several hit molecules, and we performed identifications of target proteins and biochemical characterization of these proteins.
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Chemical genetic approach toward eradication of noxious parasitic weed Striga hermonthica
Grant number：15KT0031 2015.7 - 2018.3
Tsuchiya Yuichiro
Authorship：Principal investigator
Grant amount：\18070000 （ Direct Cost: \13900000 、 Indirect Cost：\4170000 ）
A nixious parasitic plant called Striga hermonthica (Striga) represents a major threat to food security in Africa. In this research project, I focused on a host-depent germination mechanism in Striga and use it to develop a specific herbicide that lead the seeds to "suicide germination". The developed molecule (code name : SAMR690), which is composed of synthetic scaffold connected with the active core structure of strigolactones, exhibits extraordinary potency in stimulating Striga germination at femto-molar range without impinging on beneficial functions in the host strigolactone-related processes. Most importantly, the three-step procedure for synthesizing SAMO-Me-690 greatly increases the potential for Striga eradication via suicide germination campaigns in Africa.
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Molecular evolution of strigolactone signaling in the parasitic plant Striga hermonthica
Grant number：15K07102 2015.4 - 2018.3
Tsuchiya Yuichiro
Authorship：Principal investigator
Grant amount：\5070000 （ Direct Cost: \3900000 、 Indirect Cost：\1170000 ）
Strigolactones (SLs) function as plant hormone that regulate various developmental processes including suppression of shoot branching. On the other hands, seed germination of a parasitic plant Striga hermonthica is stimulated by SLs exuded by host roots. In this study, we investigated the relationship between these two functions based on the genetic interaction of HYPOSENSITIVE TO LIGHT/KARRIKIN INSENSITIVE2 ( HTL/KAI2)-mediated SL signaling pathway and light signaling pathway in Arabidopsis. We showed that HTL/KAI2 interact with SUPPRESSOR OF PHYA1 (SPA1), a negative regulator of light signaling, in SL-dependent manner, and this interaction lead SPA1 protein to degradation in planta. We transferred the knowledge to Striga with the discovery of small molecule antagonist of HTL/KAI2 that also inhibit SL-dependent germination of Striga. These results suggest that the evolution of SL pathway took place with its interaction with light signaling pathway in the parasitic plant.