Updated on 2024/10/18

写真a

 
TANAKA Miyako
 
Organization
Research Institute of Environmental Medicine Division of Stress Recognition and Response Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 1

  1. 博士(医学) ( 2009.3   東京医科歯科大学 ) 

Research Interests 4

  1. マクロファージ

  2. 炎症

  3. メタボリックシンドローム

  4. 肥満

Research Areas 1

  1. Life Science / Metabolism and endocrinology  / obesity, adipose tissue, macrophage

Current Research Project and SDGs 2

  1. エレクトロニクスフリーのインスリンデバイスの開発

  2. 微小環境に着目した炎症遷延化の分子機構解明

Research History 6

  1. Nagoya University   Lecturer

    2020.1

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    Country:Japan

  2. Nagoya University   Assistant Professor

    2015.7 - 2019.12

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    Country:Japan

  3. Tokyo Medical and Dental University   Designated assistant professor

    2014.4 - 2015.6

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    Country:Japan

  4. Tokyo Medical and Dental University

    2012.4 - 2014.3

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    Country:Japan

  5. Tokyo Medical and Dental University   Endowed chair assistant professor

    2011.4 - 2012.3

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    Country:Japan

  6. Tokyo Medical and Dental University   Designated assistant professor

    2009.4 - 2011.3

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    Country:Japan

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Education 2

  1. Tokyo Medical and Dental University

    2005.4 - 2009.3

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    Country: Japan

  2. Kyoto University   Faculty of Agriculture

    1993.4 - 1997.3

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    Country: Japan

Professional Memberships 6

  1. 日本免疫学会

    2023

  2. 日本糖尿病・肥満動物学会

    2012

  3. 日本内分泌学会   評議員

    2005

  4. 日本肥満学会   評議員

    2005

  5. 日本栄養・食糧学会

    2002

  6. 日本農芸化学会

    1999

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Committee Memberships 3

  1. 文部科学省   学術調査官  

    2020.8 - 2022.7   

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    Committee type:Government

  2. 日本肥満学会   評議員  

    2016.4   

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    Committee type:Academic society

  3. 日本内分泌学会   評議員  

    2015.4   

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    Committee type:Academic society

Awards 4

  1. 第39回 研究奨励賞

    2019.5   一般社団法人 日本内分泌学会   細胞間クロストーク・臓器間ネットワークに着目した肥満・糖尿病の病態解明

    田中 都

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  2. 第15回 若手研究奨励賞

    2014.4   一般財団法人 日本内分泌学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  3. 第6回 若手研究奨励賞

    2013.2   日本糖尿病・肥満動物学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  4. 第7回 若手研究奨励賞

    2009.10   一般財団法人 日本肥満学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

 

Papers 45

  1. C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury Reviewed

    Tanaka Miyako, Saka-Tanaka Marie, Ochi Kozue, Fujieda Kumiko, Sugiura Yuki, Miyamoto Tomofumi, Kohda Hiro, Ito Ayaka, Miyazawa Taiki, Matsumoto Akira, Aoe Seiichiro, Miyamoto Yoshihiro, Tsuboi Naotake, Maruyama Shoichi, Suematsu Makoto, Yamasaki Sho, Ogawa Yoshihiro, Suganami Takayoshi

    JOURNAL OF EXPERIMENTAL MEDICINE   Vol. 217 ( 11 ) page: e20192230   2020.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1084/jem.20192230

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  2. Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice Reviewed

    A. Matsumoto*, M. Tanaka*, H. Matsumoto, K. Ochi, Y. Moro-oka, H. Kuwata, H. Yamada, I. Shirakawa, T. Miyazawa, H. Ishii, K. Kataoka, Y. Ogawa, Y. Miyahara, T. Suganami

    Science advances   Vol. 3 ( 11 ) page: eaaq0723   2017.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/sciadv.aaq0723

  3. Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. Reviewed

    M. Tanaka, K. Ikeda, T. Suganami, C. Komiya, K. Ochi, I. Shirakawa, M. Hamaguchi, S. Nishimura, I. Manabe, T. Matsuda, K. Kimura, H. Inoue, Y. Inagaki, S. Aoe, S. Yamasaki, Y. Ogawa

    Nat Commun   Vol. 5   page: 4982   2014.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms5982

  4. Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis. Reviewed

    Ishihara T, Kato K, Matsumoto K, Tanaka M, Hara A, Shiraki Y, Morisaki H, Urano Y, Ando R, Ito K, Mii S, Esaki N, Furuhashi K, Takefuji M, Suganami T, Murohara T, Enomoto A.

    Genes to Cells     page: 1 - 19   2024.8

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    Language:English  

    DOI: 10.1111/gtc.13154

  5. Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia. Reviewed

    Oya M, Miyasaka Y, Nakamura Y, Tanaka M, Suganami T, Mashimo T, Nakamura K

    Cell metabolism   Vol. 36   page: 1 - 15   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cmet.2024.02.010

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  6. Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH Reviewed

    Itoh Michiko, Tamura Atsushi, Kanai Sayaka, Tanaka Miyako, Kanamori Yohei, Shirakawa Ibuki, Ito Ayaka, Oka Yasuyoshi, Hidaka Isao, Takami Taro, Honda Yasushi, Maeda Mitsuyo, Saito Yasuyuki, Murata Yoji, Matozaki Takashi, Nakajima Atsushi, Kataoka Yosky, Ogi Tomoo, Ogawa Yoshihiro, Suganami Takayoshi

    JOURNAL OF EXPERIMENTAL MEDICINE   Vol. 220 ( 11 ) page: e20220681   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1084/jem.20220681

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  7. Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages Reviewed

    CELL DEATH & DISEASE   Vol. 14 ( 2 ) page: 136   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41419-023-05622-5

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  8. Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84 Reviewed

    Ohue-Kitano Ryuji, Nonaka Hazuki, Nishida Akari, Masujima Yuki, Takahashi Daisuke, Ikeda Takako, Uwamizu Akiharu, Tanaka Miyako, Kohjima Motoyuki, Igarashi Miki, Katoh Hironori, Tanaka Tomohiro, Inoue Asuka, Suganami Takayoshi, Hase Koji, Ogawa Yoshihiro, Aoki Junken, Kimura Ikuo

    JCI INSIGHT   Vol. 8 ( 2 ) page: e165469   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1172/jci.insight.165469

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  9. Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis Reviewed

    Inoue Takayuki, Fu Bin, Nishio Miwako, Tanaka Miyako, Kato Hisashi, Tanaka Masashi, Itoh Michiko, Yamakage Hajime, Ochi Kozue, Ito Ayaka, Shiraki Yukihiro, Saito Satoshi, Ihara Masafumi, Nishimura Hideo, Kawamoto Atsuhiko, Inoue Shian, Saeki Kumiko, Enomoto Atsushi, Suganami Takayoshi, Satoh-Asahara Noriko

    NUTRIENTS   Vol. 15 ( 2 ) page: 350   2023.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/nu15020350

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  10. Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome Reviewed

    Hachiya Rumi, Tanaka Miyako, Itoh Michiko, Suganami Takayoshi

    INFLAMMATION AND REGENERATION   Vol. 42 ( 1 ) page: 13   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s41232-022-00198-7

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  11. A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin Delivery. Reviewed

    Chen S, Miyazaki T, Itoh M, Matsumoto H, Moro-Oka Y, Tanaka M, Miyahara Y, Suganami T, Matsumoto A

    Gels (Basel, Switzerland)   Vol. 8 ( 2 ) page: 74   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/gels8020074

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  12. The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model Reviewed

    Yoshioka Naoki, Tanaka Miyako, Ochi Kozue, Watanabe Akiko, Ono Kenji, Sawada Makoto, Ogi Tomoo, Itoh Michiko, Ito Ayaka, Shiraki Yukihiro, Enomoto Atsushi, Ishigami Masatoshi, Fujishiro Mitsuhiro, Ogawa Yoshihiro, Suganami Takayoshi

    BIOMEDICINE & PHARMACOTHERAPY   Vol. 140   page: 111738   2021.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.biopha.2021.111738

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  13. Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity Reviewed

    Kobayashi Azusa, Ito Ayaka, Shirakawa Ibuki, Tamura Atsushi, Tomono Susumu, Shindou Hideo, Hedde Per Niklas, Tanaka Miyako, Tsuboi Naotake, Ishimoto Takuji, Akashi-Takamura Sachiko, Maruyama Shoichi, Suganami Takayoshi

    FRONTIERS IN IMMUNOLOGY   Vol. 12   page: 650856   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fimmu.2021.650856

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  14. Macrophages rely on extracellular serine to suppress aberrant cytokine production Reviewed

    Kurita Kento, Ohta Hiroya, Shirakawa Ibuki, Tanaka Miyako, Kitaura Yasuyuki, Iwasaki Yorihiro, Matsuzaka Takashi, Shimano Hitoshi, Aoe Seiichiro, Arima Hiroshi, Ogawa Yoshihiro, Ito Ayaka, Suganami Takayoshi

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 11137   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-90086-w

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  15. Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH Reviewed

    Kanamori Yohei, Tanaka Miyako, Itoh Michiko, Ochi Kozue, Ito Ayaka, Hidaka Isao, Sakaida Isao, Ogawa Yoshihiro, Suganami Takayoshi

    ISCIENCE   Vol. 24 ( 2 ) page: 102032   2021.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.isci.2020.102032

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  16. Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome Reviewed

    Oka Yasuyoshi, Hamada Motoharu, Nakazawa Yuka, Muramatsu Hideki, Okuno Yusuke, Higasa Koichiro, Shimada Mayuko, Takeshima Honoka, Hanada Katsuhiro, Hirano Taichi, Kawakita Toshiro, Sakaguchi Hirotoshi, Ichimura Takuya, Ozono Shuichi, Yuge Kotaro, Watanabe Yoriko, Kotani Yuko, Yamane Mutsumi, Kasugai Yumiko, Tanaka Miyako, Suganami Takayoshi, Nakada Shinichiro, Mitsutake Norisato, Hara Yuichiro, Kato Kohji, Mizuno Seiji, Miyake Noriko, Kawai Yosuke, Tokunaga Katsushi, Nagasaki Masao, Kito Seiji, Isoyama Keiichi, Onodera Masafumi, Kaneko Hideo, Matsumoto Naomichi, Matsuda Fumihiko, Matsuo Keitaro, Takahashi Yoshiyuki, Mashimo Tomoji, Kojima Seiji, Ogi Tomoo

    SCIENCE ADVANCES   Vol. 6 ( 51 ) page: eabd7197   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/sciadv.abd7197

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  17. Temperature-Stable Boronate Gel-Based Microneedle Technology for Self-Regulated Insulin Delivery Reviewed

    Chen Siyuan, Miyazaki Takuya, Itoh Michiko, Matsumoto Hiroko, Moro-oka Yuki, Tanaka Miyako, Miyahara Yuji, Suganami Takayoshi, Matsumoto Akira

    ACS APPLIED POLYMER MATERIALS   Vol. 2 ( 7 ) page: 2781 - 2790   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsapm.0c00341

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  18. Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system. Reviewed

    Matsumoto A, Kuwata H, Kimura S, Matsumoto H, Ochi K, Moro-Oka Y, Watanabe A, Yamada H, Ishii H, Miyazawa T, Chen S, Baba T, Yoshida H, Nakamura T, Inoue H, Ogawa Y, Tanaka M, Miyahara Y, Suganami T

    Communications biology   Vol. 3 ( 1 ) page: 313   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42003-020-1026-x

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  19. Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair. Reviewed

    Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T

    Cell   Vol. 180 ( 6 ) page: 1228-1244.e24   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cell.2020.02.010

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  20. Molecular mechanism of obesity-induced adipose tissue inflammation; the role of Mincle in adipose tissue fibrosis and ectopic lipid accumulation Invited Reviewed

    Tanaka Miyako

    ENDOCRINE JOURNAL   Vol. 67 ( 2 ) page: 107-111   2020.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1507/endocrj.EJ19-0417

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  21. Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects. Reviewed

    Kawakubo M, Tanaka M, Ochi K, Watanabe A, Saka-Tanaka M, Kanamori Y, Yoshioka N, Yamashita S, Goto M, Itoh M, Shirakawa I, Kanai S, Suzuki H, Sawada M, Ito A, Ishigami M, Fujishiro M, Arima H, Ogawa Y, Suganami T

    Scientific reports   Vol. 10 ( 1 ) page: 983   2020.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-57935-6

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  22. Smart Microneedle Fabricated with Silk Fibroin Combined Semi interpenetrating Network Hydrogel for Glucose-Responsive Insulin Delivery Reviewed

    Chen Siyuan, Matsumoto Hiroko, Moro-oka Yuki, Tanaka Miyako, Miyahara Yuji, Suganami Takayoshi, Matsumoto Akira

    ACS BIOMATERIALS SCIENCE & ENGINEERING   Vol. 5 ( 11 ) page: 5781-5789   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsbiomaterials.9b00532

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  23. Microneedle-Array Patch Fabricated with Enzyme-Free Polymeric Components Capable of On-Demand Insulin Delivery Reviewed

    Chen Siyuan, Matsumoto Hiroko, Moro-oka Yuki, Tanaka Miyako, Miyahara Yuji, Suganami Takayoshi, Matsumoto Akira

    ADVANCED FUNCTIONAL MATERIALS   Vol. 29 ( 7 )   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/adfm.201807369

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  24. Molecular mechanism of obesity-induced "metabolic" tissue remodeling. Reviewed

    M. Tanaka, M. Itoh, Y. Ogawa, T. Suganami

    J Diabetes Investig     2017.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.12769

  25. WNK4 is an adipogenic factor and its deletion reduces diet- induced obesity in mice. Reviewed

    D. Takahashi, T. Mori, E. Sohara, M. Tanaka, M. Chiga, Y. Inoue, N. Nomura, M. Zeniya, H. Ochi, S. Takeda, T. Suganami, T. Rai, S. Uchida

    EBioMedicine   Vol. 18   page: 118-127   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ebiom.2017.03.011

  26. Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis. Reviewed

    C. Komiya*, M. Tanaka*, K. Tsuchiya, N. Shimazu, K. Mori, S. Furuke, Y. Miyachi, K. Shiba, S. Yamaguchi, K. Ikeda, K. Ochi, K. Nakabayashi, K. Hata, M. Itoh, T. Suganami, Y. Ogawa

    Scientific reports   Vol. 7   page: 44754   2017.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep44754

  27. Inflammatory responses increase secretion of MD-1 protein. Reviewed

    R. Thomas Jennings, E. Odkhuu, A. Nakashima, N. Morita, T. Kobayashi, I. Yamai, M. Tanaka, T. Suganami, S. Haga, M. Ozaki, Y. Watanabe, Y. Nagai, K. Takatsu, T. Kikuchi-Ueda, I. Ichimonji, Y. Ogawa, H. Takagi, T. Yamazaki, K. Miyake, S. Akashi-Takamura

    International immunology   Vol. 10   page: 503-512   2016.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/intimm/dxw031

  28. The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages. Reviewed

    R. Hachiya, T. Shiihashi, I. Shirakawa, Y. Iwasaki, Y. Matsumura, Y. Oishi, Y. Nakayama, Y. Miyamoto, I. Manabe, K. Ochi, M. Tanaka, N. Goda, J. Sakai, T. Suganami, Y. Ogawa

    Scientific reports   Vol. 6   page: 28845   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep28845

  29. Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice. Reviewed

    Y. Watanabe, Y. Nagai, H. Honda, N. Okamoto, S. Yamamoto, T. Hamashima, Y. Ishii, M. Tanaka, T. Suganami, M. Sasahara, K. Miyake, K. Takatsu

    Scientific reports   Vol. 6   page: 23097   2016.3

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    DOI: 10.1038/srep23097

  30. Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages. Reviewed

    Y. Iwasaki, T. Suganami, R. Hachiya, I. Shirakawa, M. Kim-Saijo, M. Tanaka, M. Hamaguchi, T. Takai-Igarashi, M. Nakai, Y. Miyamoto, Y. Ogawa

    Diabetes   Vol. 63 ( 1 ) page: 152-161   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/db13-0757

  31. Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver. Reviewed

    T. Ehara, Y. Kamei, M. Takahashi, X. Yuan, S. Kanai, E. Tamura, M. Tanaka, T. Yamazaki, S. Miura, O. Ezaki, T. Suganami, M. Okano, Y. Ogawa

    Diabetes   Vol. 61 ( 10 ) page: 2442-2450   2012.10

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    DOI: 10.2337/db11-1834

  32. Adipose tissue inflammation and ectopic lipid accumulation. Invited Reviewed

    T. Suganami, M. Tanaka, Y. Ogawa

    Endocrine journal   Vol. 59 ( 10 ) page: 849-857   2012

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  33. Melanocortin 4 receptor-deficient mice as a novel mouse model of non-alcoholic steatohepatitis. Reviewed

    M. Itoh, T. Suganami, N. Nakagawa, M. Tanaka, Y. Yamamoto, Y. Kamei, S. Terai, I. Sakaida, Y. Ogawa

    Am J Pathol   Vol. 179   page: 2455-2464   2011

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  34. Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans. Reviewed

    M. Ichioka, T. Suganami, N. Tsuda, I. Shirakawa, Y. Hirata, N. Satoh-Asahara, Y. Shimoda, M. Tanaka, M. Kim-Saijo, Y. Miyamoto, Y. Kamei, M. Sata, Y. Ogawa

    Diabetes   Vol. 60   page: 819-826   2011

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  35. Role of central leptin signaling in the starvation-induced alteration of B-cell development. Reviewed

    M. Tanaka, T. Suganami, M. Kim-Saijo, C. Toda, M. Tsuiji, K. Ochi, Y. Kamei, Y. Minokoshi, Y. Ogawa

    J Neurosci   Vol. 31   page: 8373-8380   2011

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  36. Role of central leptin signaling in renal macrophage infiltration. Reviewed

    M. Tanaka, T. Suganami, S. Sugita, Y. Shimoda, M. Kasahara, S. Aoe, M. Takeya, S. Takeda, Y. Kamei, Y. Ogawa

    Endocr J   Vol. 57   page: 61-72   2010

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  37. Role of C-C chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. Reviewed

    A. Ito, T. Suganami, A. Yamauchi, M. Degawa-Yamauchi, M. Tanaka, R. Kouyama, Y. Kobayashi, N. Nitta, K. Yasuda, Y. Hirata, W.A. Kuziel, M. Takeya, S. Kanegasaki, Y. Kamei, Y. Ogawa

    J Biol Chem   Vol. 283   page: 35715-35723   2008

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  38. Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. Reviewed

    M. Itoh, T. Suganami, N. Satoh, K.Tanimoto-Koyama, X. Yuan, M. Tanaka, H. Kawano, T. Yano, S. Aoe, M. Takeya, A. Shimatsu, H. Kuzuya, Y. Kamei, Y. Ogawa

    Arterioscler Thromb Vasc Biol   Vol. 27   page: 1918-1925   2007

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  39. Human MDR1 and MRP1 recognize berberine as their transport substrate. Reviewed

    N. Shitan, M. Tanaka, K. Terai, K. Ueda, K. Yazaki

    Biosci Biotechnol Biochem   Vol. 71   page: 242-245   2007

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  40. Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor. Reviewed

    R. Kouyama, T. Suganami, J. Nishida, M. Tanaka, T. Toyoda, M. Kiso, T. Chiwata, Y. Miyamoto, Y. Yoshimasa, A. Fukamizu, M. Horiuchi, Y. Hirata, Y. Ogawa

    Endocrinology   Vol. 146   page: 3481-3489   2005

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  41. Application of Phospholipids Extracted from Bovine Milk to the Reconstitution of Cream Using Butter Oil. Reviewed

    S. Miura, M. Tanaka, A. Suzuki, K. Sato

    J Am Oil Chem Soc   Vol. 81   page: 97-100   2004

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  42. Milk sphingomyelin accelerates enzymatic and morphological maturation of intestine in artificially reared rats. Reviewed

    M. Motouri, H. Matsuyama, J. Yamamura, M. Tanaka, S. Aoe, T. Iwanaga, H. Kawakami

    J Pediatr Gastroenterol Nutr   Vol. 36   page: 241-247   2003

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    Language:English   Publishing type:Research paper (scientific journal)  

  43. Milk basic protein: A novel protective function of milk against osteoporosis. Reviewed

    Y. Toba, Y. Takada, J. Yamamura, M. Tanaka, Y. Matsuoka, H. Kawakami, A. Itabashi, S. Aoe, M. Kumegawa

    Bone   Vol. 27   page: 403-408   2000

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    Language:English   Publishing type:Research paper (scientific journal)  

  44. Bioavailability of milk micellar calcium phosphate-phosphopeptide complex in rats. Reviewed

    Y. Toba, K. Kato, Y. Takada, M. Tanaka, T. Nakano, T. Aoki, S. Aoe

    J Nutr Sci Vitaminol   Vol. 45   page: 311-323   1999

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    Language:English   Publishing type:Research paper (scientific journal)  

  45. Comparison of the effects of milk components and calcium source on calcium bioability in glowing male rats. Reviewed

    Y. Toba, Y. Takada, M. Tanaka, S. Aoe

    Nutr Res   Vol. 19   page: 449-459   1999

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    Language:English   Publishing type:Research paper (scientific journal)  

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Books 22

  1. 腎疾患と炎症記憶

    田中 都,菅波孝祥( Role: Joint author)

    細胞,ニューサイエンス社  2024.10 

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    Responsible for pages:16-19   Language:Japanese

  2. 肝疾患と細胞死

    田中 都,菅波孝祥( Role: Joint author)

    The Lipid,メディカルレビュー社  2024.10 

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    Responsible for pages:50-55   Language:Japanese Book type:General book, introductory book for general audience

  3. 慢性腎臓病とMASH

    田中 都,菅波孝祥( Role: Joint author)

    臨床免疫・アレルギー科,科学評論社  2024.5 

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    Language:Japanese Book type:General book, introductory book for general audience

  4. もっとよくわかる!線維化と疾患

    ( Role: Edit)

    羊土社  2023.9  ( ISBN:978-4-7581-2213-9

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    Total pages:172   Language:Japanese

  5. 脂肪組織 〜さまざまな病態をもたらす脂肪組織の線維化

    田中 都,菅波孝祥( Role: Joint author)

    羊土社  2023.9  ( ISBN:978-4-7581-2213-9

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    Total pages:172   Language:Japanese

  6. マクロファージ以外の免疫細胞

    田中 都,菅波孝祥( Role: Joint author)

    羊土社  2023.9  ( ISBN:978-4-7581-2213-9

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    Total pages:172   Language:Japanese

  7. 異所性脂肪と自然免疫

    田中 都,菅波孝祥( Role: Joint author)

    外科と代謝・栄養.日本外科代謝栄養学会  2021.7 

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    Responsible for pages:120-123   Language:Japanese

  8. C型レクチン受容体Mincle関連疾患

    田中 都,菅波孝祥( Role: Joint author)

    臨床免疫・アレルギー科. 科学評論社  2021.5 

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    Responsible for pages:615-620   Language:Japanese

  9. 脂肪組織の線維化メカニズム

    菅波孝祥,田中 都,小川佳宏( Role: Joint author)

    実験医学増刊号.羊土社  2021.3  ( ISBN:978-4-7581-0393-0

  10. アディポカインと老化・老化関連疾患

    神田 容,田中 都,菅波孝祥( Role: Joint author)

    老年内科.科学評論社  2020.12 

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    Language:Japanese

  11. 脂肪組織の線維化

    田中 都,菅波孝祥( Role: Joint author)

    実験医学増刊号.羊土社  2020.7  ( ISBN:978-4-7581-0388-6

  12. 炎症・線維化による脂肪組織機能の制御

    田中 都,小川佳宏,菅波孝祥( Role: Joint author)

    実験医学.羊土社  2018.10  ( ISBN:978-4-7581-2512-3

  13. メタボリックシンドロームと自然免疫

    田中 都,菅波孝祥( Role: Joint author)

    医学のあゆみ.医歯薬出版株式会社  2018.6 

  14. 健全なる身体には健全なる脂肪組織を

    田中 都( Role: Sole author)

    生物工学会誌.日本生物工学会  2018 

  15. 肥満に伴う死亡組織の線維化を招く鍵分子

    田中 都,菅波孝祥( Role: Joint author)

    医学のあゆみ.医歯薬出版株式会社  2016.5 

  16. 脂肪組織の線維化を調節する分子Mincle

    田中 都,菅波孝祥( Role: Joint author)

    医学のあゆみ.医歯薬出版株式会社  2016.5 

  17. MC4R

    田中 都,菅波孝祥( Role: Joint author)

    医学のあゆみ.医歯薬出版株式会社  2016.1 

  18. 脂質と免疫センサー

    田中 都,菅波孝祥,小川佳宏( Role: Joint author)

    炎症と免疫.先端医学社  2015.10 

  19. Innovative Medicine: Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies

    Yoshihiro Ogawa, Takayoshi Suganami, Michiko Itoh, Miyako Tanaka( Role: Joint author)

    2015 

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    Language:English

  20. 糖尿病・肥満/感染症―疾患モデルの作成と利用 「ob/obマウス」

    田中 都,小川佳宏( Role: Joint author)

    (株)エル・アイ・シー  2012 

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    Language:Japanese

  21. 肥満と脂肪エネルギー代謝 メタボリックシンドロームへの戦略 「脂肪組織リモデリングの分子機構と医学応用」

    小川佳宏,菅波孝祥,伊藤綾香,田中 都,伊藤美智子,亀井康富( Role: Joint author)

    (株)建帛社  2008.4 

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    Language:Japanese

  22. カラー版 糖尿病学 基礎と臨床 「レプチンシグナル」

    菅波孝祥,田中 都,小川佳宏( Role: Joint author)

    (株)西村書店  2007.6 

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Presentations 57

  1. 基礎研究から紐解くAKI Invited International coauthorship

    田中 都,菅波孝祥

    第67回日本腎臓学会学術総会  2024.6.28 

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    Event date: 2024.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:横浜   Country:Japan  

  2. メタボリックシンドローム発症機序の新たな展開:脂肪組織と代謝関連組織の連関と炎症、貪食、細胞死による調節機構 Invited

    田中 都,菅波孝祥

    第101回日本生理学会大会  2024.3.31 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:小倉   Country:Japan  

  3. Cell death-induced chronic inflammation and metabolic changes in macrophage Invited

    Miyako Tanaka, Takayoshi Suganami

    2022.12.7 

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    Event date: 2022.12

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  4. 細胞死とマクロファージがもたらす慢性炎症の病態メカニズム Invited

    田中 都,菅波孝祥

    第43回日本肥満学会・第40回日本肥満症治療学会学術集会  2022.12.2  日本肥満学会

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    Event date: 2022.12

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:沖縄   Country:Japan  

  5. Clearance of dead cells and altered cellular metabolism in macrophages as a novel molecular mechanism of chronic inflammation Invited

    Miyako Tanaka, Takayoshi Suganami

    2022.11.30 

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    Event date: 2022.11 - 2022.12

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  6. 細胞死を起点とした炎症慢性化機構とメタボリックシンドロームにおける意義

    田中 都,菅波孝祥

    第96回 日本糖尿病学会中部地方会  2022.11.19  日本糖尿病学会中部地方会

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    Event date: 2022.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:富山   Country:Japan  

  7. Clearance of dead cells and altered cellular metabolism in macrophages as a novel molecular mechanism of chronic inflammation Invited

    2022.10.12 

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    Event date: 2022.10

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  8. 細胞死を起点としたマクロファージの代謝変動と慢性炎症のメカニズム Invited

    田中 都,菅波孝祥

    第94回日本生化学会大会  2021.11.3  日本生化学会

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:online  

  9. 慢性炎症から紐解く代謝性疾患の病態メカニズム Invited

    田中 都,小川佳宏,菅波孝祥

    第78回日本栄養・食糧学会中部支部大会  2021.9.18  日本栄養・食糧学会中部支部

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋(onlline)  

  10. 過栄養がもたらす細胞死と炎症,線維化 Invited

    田中 都,小川佳宏,菅波孝祥

    第75回日本栄養・食糧学会大会  2021.7.3  日本栄養・食糧学会

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京(online)   Country:Japan  

  11. 細胞死を起点とした慢性炎症・生活習慣病のメカニズム Invited

    田中 都,小川佳宏,菅波孝祥

    第64回日本糖尿病学会年次学術集会  2021.5.21  日本糖尿病学会

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:富山(online)   Country:Japan  

  12. Role of Mincle in sterile inflammation Invited

    Miyako Tanaka, Yoshihiro Ogawa, Takayoshi Suganami

    2021.3.26 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  13. 組織リモデリングとMincle Invited

    田中 都,小川佳宏,菅波孝祥

    第41回日本肥満学会  2021.3.20  日本肥満学会

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン   Country:Japan  

  14. C-type lectin Mincle mediates cell death-triggered sustained inflammation Invited

    Miyako Tanaka,Yoshihiro Ogawa,Takayoshi Suganami

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    Event date: 2020.3

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  15. C-type lectin Mincle mediates cell death-triggered sustained inflammation after acute kidney injury in mice International conference

    Miyako Tanaka, Marie Saka-Tanaka, Kozue Ochi, Kumiko Fujieda, Hiro Ishihara, Naotake Tsuboi, Shoichi Maruyama, Yoshihiro Ogawa, Takayoshi Suganami

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    Event date: 2020.2

    Language:English   Presentation type:Poster presentation  

    Venue:Victoria, Canada   Country:Canada  

  16. 新規死細胞センサー Mincleを介するマクロファージ・死細胞ネットワークと炎症遷延化機構 Invited

    田中 都,小川佳宏,菅波孝祥

    第42回日本分子生物学会年会 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  17. 新規細胞死センサーMincleによる急性腎障害の炎症慢性化機

    田中 都,坂(田中)まりえ,越智 梢,藤枝久美子,神田 容,坪井直毅,丸山彰一,小川佳宏,菅波孝祥

    第92回日本内分泌学会学術総会 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  18. 細胞間クロストーク・臓器間ネットワークに着目した肥満・糖尿病の病態解明 Invited

    田中 都

    第92回日本内分泌学会学術総会 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  19. Synthetic smart gel provides glucose-responsive insulin delivery in diabetic mice International conference

    Miyako Tanaka, Akira Matsumoto, Hiroko Matsumoto, Kozue Ochi, Yuki Moro-oka, Hirohito Kuwata, Ibuki Shirakawa, Taiki Miyazawa, Yuji Miyahara, Takayoshi Suganami

    2019 Keystone Symposia for the meeting on Obesity and Adipose Tissue Biology 

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    Event date: 2019.2

    Language:English   Presentation type:Poster presentation  

    Country:Canada  

  20. C-type lectin Mincle accelerates renal ischemia-reperfusion injury International conference

    The American Society of Nephrology Kidney Week 2018 

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    Event date: 2018.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  21. アディポカインによる炎症・免疫制御 Invited

    田中 都,蜂屋瑠見,小川佳宏,菅波孝祥

    第18回日本抗加齢医学会総会 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  22. C-type lectin Mincle accelerates renal ischemia-reperfusion injury International conference

    Miyako Tanaka, Marie Saka-Tanaka, Kozue Ochi, Kumiko Fujieda, Hiro Kohda, Naotake Tsuboi, Shoichi Maruyama, Tomofumi Miyamoto, Sho Yamasaki, Yoshihiro Ogawa, Takayoshi Suganami

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    Event date: 2018.5

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  23. 緑豆タンパク質の生活習慣病予防効果 〜脂肪肝,脂肪組織炎症に着目して〜

    田中 都,越智 梢,渡辺亜希子,木村久美,橘 伸彦,井上 啓,菅波孝祥

    第72回 日本栄養・食糧学会大会 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山   Country:Japan  

  24. 急性腎障害における新規細胞死センサーMincleの病態生理的意義

    田中 都,坂(田中)まりえ,越智 梢,神田 容,藤枝久美子,山﨑 晶,坪井直毅,丸山彰一,小川佳宏,菅波孝祥

    第22回心血管内分泌代謝学会学術集会 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎   Country:Japan  

  25. グルコース応答性スマートゲルを用いた新規インスリンデバイスの開発

    田中 都,桒田博仁,越智 梢,松本裕子,後藤沙也香,白川伊吹,宮原裕二,石井 均,小川佳宏,松元 亮,菅波孝祥

    第91回日本内分泌学会学術総会 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  26. Mincle, macrophage-inducible C-type lectin, plays an important role in the pathogenesis of renal ischemia-reperfusion injury International conference

    Miyako Tanaka, Marie Saka-Tanaka, Kozue Ochi, Kumiko Fujieda, Hiro Kohda, Naotake Tsuboi, Shoichi Maruyama, Yoshihiro Ogawa, Takayoshi Suganami

    2018 Keystone Symposia for the meeting on The Resolution of Inflammation in Health and Disease 

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    Event date: 2018.3

    Language:English   Presentation type:Poster presentation  

    Country:Ireland  

  27. グルコース応答性ゲルを用いた自律的インスリンデバイスの開

    田中 都,桒田博仁,越智 梢,松本裕子,白川伊吹,宮原裕二,石井 均,小川佳宏,松元 亮,菅波孝祥

    第38回日本肥満学会学術大会 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  28. スマートインスリンデバイスによる新しい糖尿病治療戦略の開発

    田中 都,桒田博仁,越智 梢,松本裕子,白川伊吹,宮原裕二,石井 均,小川佳宏,松元 亮,菅波孝祥

    第90回日本内分泌学会学術総会 

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    Event date: 2017.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都   Country:Japan  

  29. イムノメタボリズムと脂肪組織炎症 Invited

    田中 都,越智梢,菅波孝祥,小川佳宏

    第37回日本肥満学会 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  30. メタボリックシンドロームと脂肪組織機能破綻 Invited

    田中 都,越智梢,菅波孝祥,小川佳宏

    第89回日本内分泌学会学術総会 

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    Event date: 2016.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  31. Mincle, a novel pathogen sensor in macrophages, underlies obesity-induced adipose tissue fibrosis in mice International conference

    Miyako Tanaka, Kozue Ochi, Yoshihiro Ogawa, Takayoshi Suganami

    2016 Keystone Symposia for the meeting on Fibrosis: From Basic Mechanisms to Targeted Therapies 

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    Event date: 2016.2

    Language:English   Presentation type:Poster presentation  

    Venue:Keystone Resort, USA   Country:United States  

  32. 生体の脂質代謝異常とアディポサイトカイン Invited

    田中 都,菅波孝祥,小川佳宏

    第23回日本心血管内分泌代謝学会 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  33. メタボリックシンドロームにおける脂肪組織炎症・線維化の意義と分子機構解明

    田中 都,菅波孝祥,小川佳宏

    第59回日本薬学会関東支部大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:千葉   Country:Japan  

  34. 肥満脂肪組織の線維化分子機構について Invited

    田中 都,菅波孝祥,小川佳宏

    第58回日本糖尿病学会年次学術集会 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  35. Macrophage-inducible C-type lectin underlies obesity-induced adipose fibrosis International conference

    Miyako Tanaka, Takayoshi Suganami, Kenji Ikeda, Chikara Komiya, Yoshihiro Ogawa

    2015 Keystone Symposia for the meeting on Obesity and the Metabolic Syndrome: Mitochondria and Energy Expenditure 

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    Event date: 2015.3

    Language:English   Presentation type:Poster presentation  

    Venue:Whistler, British Columbia, Canada   Country:Canada  

  36. 脂肪組織炎症による異所性脂肪蓄積の分子機構 Invited

    田中 都,菅波孝祥,小川佳宏

    第35回日本肥満学会学術大会 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  37. 病原体センサー・内因性リガンド系による脂肪組織線維化の分子機構と異所性脂肪蓄積における意義

    田中 都,菅波孝祥,池田賢司,小宮 力,白川伊吹,越智 梢,小川佳宏

    第87回日本内分泌学会学術総会 

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    Event date: 2014.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  38. Mincle, a novel pathogen sensor in macrophages, underlies obesity-induced adipose tissue fibrosis in mice International conference

    Miyako Tanaka, Takayoshi Suganami, Kenji Ikeda, Chikara Komiya, Yoshihiro Ogawa

    2014 Keystone Symposia for the meeting on Innate Immunity, Metabolism and Vascular Injury 

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    Event date: 2014.3

    Language:English   Presentation type:Poster presentation  

    Venue:Whistler, British Columbia, Canada   Country:Canada  

  39. 脂肪組織線維化の分子機構と異所性脂肪蓄積における意義

    田中 都,菅波孝祥,池田賢司,小宮 力,白川伊吹,越智 梢,小川佳宏

    第51回日本臨床分子医学会学術集会 

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    Event date: 2014.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  40. 脂肪組織炎症における病原体センサー・Mincleの意義

    田中 都,菅波孝祥,池田賢司,小宮力,白川伊吹,越智梢,青江誠一郎,亀井康富,小川佳宏

    第34回日本肥満学会学術大会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  41. 肥満に関連する慢性炎症における新規病原体センサーの病態生理的意義

    田中 都,菅波孝祥,池田賢司,小宮力,白川伊吹,越智梢,亀井康富,小川佳宏

    第27回日本糖尿病・肥満動物学会年次学術集会 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  42. Role of Macrophage-inducible C-type Lectin in Obesity-induced Adipose Tissue Inflammation International conference

    Miyako Tanaka, Takayoshi Suganami, Kenji Ikeda, Chikara Komiya, Yoshihiro Ogawa

    2013 Keystone Symposia for the meeting on Adipose tissue inflammation 

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    Event date: 2013.1 - 2013.2

    Language:English   Presentation type:Poster presentation  

    Venue:Keystone, Colorado, USA   Country:United States  

  43. 肥満の脂肪組織における新規病原体センサー・Mincleの意義

    田中 都,菅波孝祥,池田賢司,小宮力,白川伊吹,越智梢,青江誠一郎,亀井康富,小川佳宏

    第33回日本肥満学会学術大会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  44. Role of Central Leptin Signaling in the Starvation-Induced Alteration of B-Cell Development International conference

    Miyako Tanaka, Takayoshi Suganami, Yoshihiro Ogawa

    2012 Keystone Symposia for the meeting on Complications of Diabetes: Mechanisms of Injury and Failure of Repair 

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    Event date: 2012.3

    Language:English   Presentation type:Poster presentation  

    Venue:Boston, Massachusetts, USA   Country:United States  

  45. 骨髄Bリンパ球分化に及ぼす中枢レプチンシグナルの作用機序の解明

    田中 都,菅波孝祥,西條美佐,築地信,越智梢,亀井康富,小川佳宏

    第32回日本肥満学会学術大会 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  46. 中枢性レプチンシグナルの炎症・免疫調節作用

    田中 都,菅波孝祥,亀井康富,小川佳宏

    第16回アディポサイエンス研究会シンポジウム 

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    Event date: 2011.8

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:大阪   Country:Japan  

  47. Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice International conference

    M. Tanaka, T. Suganami, M. Ichioka, Naoto, Tsuda, Y. Ogawa

    2011 Keystone Symposia for the meeting on Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction. 

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    Event date: 2011.1

    Language:English   Presentation type:Poster presentation  

    Venue:Keystone, Colorado, USA   Country:United States  

  48. レプチン

    田中 都,菅波孝祥,小川佳宏

    第31回日本肥満学会学術大会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:前橋   Country:Japan  

  49. 骨髄Bリンパ球分化に及ぼす中枢レプチン作用

    田中 都,菅波孝祥,西條美佐,築地信,亀井康富,小川佳宏

    第31回日本肥満学会学術大会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:群馬   Country:Japan  

  50. 中枢神経系を介するレプチンの炎症・免疫調節作用

    田中 都,菅波孝祥,杉田 聡,青江誠一郎,亀井康富,小川佳宏

    第30回日本肥満学会学術大会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:浜松   Country:Japan  

  51. 中枢神経系を介するレプチンの炎症調節作用

    田中 都,菅波孝祥,杉田 聡,竹屋元裕,笠原正登,竹田秀,小川佳宏

    第82回日本内分泌学会学術大会 

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    Event date: 2009.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:群馬   Country:Japan  

  52. Role of central leptin signaling in renal macrophage infiltration International conference

    Miyako Tanaka, Takayoshi Suganami, Yoshihiro Ogawa

    2009 Keystone Symposia for the meeting on Complications of Diabetes and Obesity 

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    Event date: 2009.2 - 2009.3

    Language:English   Presentation type:Poster presentation  

    Venue:Vancouver, British Columbia, Canada   Country:Canada  

  53. 中枢神経系を介するレプチンの炎症調節作用:マウス腎尿細管間質障害モデルを用いて

    田中 都,菅波孝祥,杉田 聡,竹屋元裕,笠原正登,亀井康富,小川佳宏

    第29回日本肥満学会学術大会 

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    Event date: 2008.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大分   Country:Japan  

  54. 腎障害発展および進展におけるレプチンの病態生理的意義に関する研究

    田中 都,菅波孝祥,杉田 聡,竹屋元裕,笠原正登,亀井康富,小川佳宏

    第28回日本肥満学会学術大会 

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    Event date: 2007.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  55. レプチンの炎症・線維化促進作用の分子機構:マウス腎間質線維化モデルを用いて

    田中 都,菅波孝祥,杉田 聡,岡淳一郎,竹屋元裕,笠原正登,亀井康富,小川佳宏

    第27回日本肥満学会学術大会 

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    Event date: 2006.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  56. マウス腎間質線維化モデルを用いたレプチンの炎症・線維化促進作用の検討

    田中 都,菅波孝祥,杉田聡,笠原正登,岡淳一郎,小川佳宏

    第26回日本肥満学会学術大会 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  57. 炎症・線維化促進因子としてのレプチンの病態生理的意義の検討 —マウス腎間質線維化モデルを用いて—

    田中 都,菅波孝祥,笠原正登,小川佳宏

    第78回日本内分泌学会学術総会 

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    Event date: 2005.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 25

  1. 量子ドットを利用した死細胞クリアランス評価系の確立

    2024.4

    ハーモニック伊藤財団2024年度助成 

  2. 死細胞クリアランスの可視化とNASH診断法の開発

    2024.1

    鈴木謙三記念医科学応用研究財団令和5年度調査研究助成金 

  3. 死細胞貪食に着目した新たな脂肪組織炎症制御機構の解明

    2024.1

    第3回(2023年度)日本肥満学会・ノボ ノルディスク ファーマ研究助成 

  4. 体重リバウンドと脂肪組織healthy expansionの新たな分子機構の解明

    2023.11

    タニタ健康体重基金2023年度助成金 

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    Authorship:Principal investigator 

    Grant amount:\500000 ( Direct Cost: \500000 )

  5. 量子ドットを用いた死細胞クリアランスの可視化と医学応用

    2023

    UBE学術振興財団「第63回学術奨励賞」 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1000000

  6. 死細胞クリアランスに着目した慢性炎症の分子機構解明

    2022.12

    第54回(2022年度)内藤記念科学奨励金・研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3000000 ( Direct Cost: \3000000 )

  7. 死にゆく細胞の細胞内代謝変容と炎症慢性化機構の解明

    2022

    上原記念生命科学財団  上原記念生命科学財団「2021年度 研究助成金」 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\5000000

  8. 過栄養がもたらす免疫代謝変容と臓器間ネットワークの分子機構解明

    2021.4

    AMED 肝炎等克服実用化研究事業 

    田中 都

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\7800000 ( Direct Cost: \6000000 、 Indirect Cost:\1800000 )

  9. 加齢に伴う“皮膚粗鬆症”の分子機構解明

    2021

    武田科学振興財団ビジョナリーリサーチ助成(スタート) 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000

  10. 細胞死センサーMincle が認識する内因性脂質リガンドの探索と急性腎障害における意義の解明

    2019 - 2020

    小野医学研究財団 2018年度(第31回)研究助成 

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    Grant type:Competitive

  11. 中空糸融合型人工膵臓デバイスによる新たな糖尿病治療戦略の開発

    2019 - 2020

    市原国際奨学財団 平成31(2019)年度研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

  12. 急性腎障害を起点とする炎症遷延化に及ぼすMincleの病態生理的意義の解明

    2019 - 2020

    石橋由紀子記念基金助成金 平成30年度 研究費 

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    Authorship:Principal investigator  Grant type:Competitive

  13. 死細胞センサーMincleによる炎症遷延化の分子機構解明

    2019 - 2020

    第一三共生命科学研究振興財団 2019年度 研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

  14. 腎障害の慢性化を誘導する微小環境の分子機構の解明

    2018 - 2019

    金原一郎記念医学医療振興財団2018年度上期助成 

    田中 都

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    Grant type:Competitive

  15. 急性腎障害に及ぼす細胞死センサーMincleの病態生理的意義の解明

    2018 - 2019

    テルモ生命科学芸術財団 2018年度研究助成(生理活性物質・生体成分研究) 

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    Grant type:Competitive

  16. 脂肪組織リモデリングによるリバウンドの新たな分子機構の解明

    2017 - 2018

    ひと・健康未来研究財団 研究助成 

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    Grant type:Competitive

  17. フェニルボロン酸ゲルを応用した自律的インスリンデバイスの開発研究

    2017 - 2018

    持田記念医学薬学振興財団 平成29年度持田記念研究助成金 

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    Authorship:Principal investigator  Grant type:Competitive

  18. 加齢性脂肪組織リモデリングの分子機構の解明と医学応用

    2016 - 2019

    公益財団法人長寿科学振興財団 平成28年度長寿科学研究者支援事業 

    田中 都

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    Authorship:Principal investigator  Grant type:Competitive

  19. 新たな異所性脂肪蓄積の分子機構と臨床的意義に関する研究

    2016 - 2017

    公益財団法人 鈴木謙三記念医科学応用研究財団 平成28年度調査研究助成金 

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    Grant type:Competitive

  20. 過栄養による組織リモデリングの分子機構解明と医学応用

    2016 - 2017

    堀科学芸術振興財団 第26回公益財団法人堀科学芸術振興財団 第4部研究助成 

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    Grant type:Competitive

  21. 病原体センサー・内因性リガンド系による自然炎症の制御機構の解明

    2015 - 2017

    武田科学振興財団 2015年度ビジョナリーリサーチ助成 

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    Grant type:Competitive

  22. 脂肪組織炎症・線維化の機序解明と予防成分の探索

    2015 - 2016

    三島海雲記念財団 第53回学術研究奨励金 

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    Grant type:Competitive

  23. 肥満における異所性脂肪蓄積の新たな分子機構の解明

    2015 - 2016

    花王健康科学研究会 第13回研究助成 

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    Grant type:Competitive

  24. 脂肪組織線維化の分子機構の解明と異所性脂肪蓄積における意義

    2013 - 2014

    第22回 小野医学研究奨励助成金 

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    Grant type:Competitive

  25. 飢餓時の免疫機能障害におけるレプチンの病態生理的意義に関する研究

    2010 - 2011

    花王健康科学研究会 第8回研究助成 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 細胞死がもたらす細胞内脂質代謝変容と炎症慢性化機構の解明

    Grant number:24K10076  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    田中 都

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    近年,死細胞自身が情報の発信源となって多彩な生体応答を誘導することが明らかになり,炎症慢性化における細胞死の意義が注目を集めている。非アポトーシス型細胞死では,細胞死に伴い放出される細胞内構成成分が自然免疫センサーに対する内因性リガンドとして周囲の免疫細胞に炎症反応を惹起し,種々の炎症病態を形成する。申請者は,非アポトーシス型細胞死の過程において細胞内脂質代謝変容が生じること,この代謝経路に介入することで病態モデルの炎症慢性化を制御し得ることを見出した。本研究により,障害細胞の細胞内代謝変容や内因性リガンド産生機構が明らかになり,細胞死がもたらす慢性疾患の病態解明の一端となることが期待される。

  2. 死細胞クリアランス不全がもたらす炎症慢性化機構の解明

    Grant number:23H04776  2023.4 - 2025.3

    科学研究費助成事業  学術変革領域研究(A)

    田中 都

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    Authorship:Principal investigator 

    Grant amount:\7020000 ( Direct Cost: \5400000 、 Indirect Cost:\1620000 )

    近年,死細胞自身が情報の発信源となって多彩な生体応答を誘導することが明らかになり,非感染性炎症の慢性化における細胞死の意義が注目を集めている。ネクロプトーシスやフェロトーシスなどの様々な新たな細胞死様式が報告され,細胞死の分子機構は明らかになりつつある一方で,死細胞がどのように処理されるかは不明な点が多い。特に,マクロファージが死細胞を認識し,貪食した後の消化スピードや死細胞の運命についてはほとんど分かっていない。本研究では,死細胞クリアランス不全がもたらす炎症慢性化機構の解明を通して,死細胞貪食の重要性を明らかにする。

  3. 微小代謝環境に着目した慢性炎症の分子機構解明

    Grant number:21K08526  2021.4

    日本学術振興会  科学研究費 基盤研究(C) 

    田中 都

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  4. 加齢に伴う脂肪組織の機能変容に及ぼす細胞間相互作用の分子機構の解明

    Grant number:18K08508  2018.4 - 2021.3

    科学研究費 基盤研究(C)  基盤研究(C)

    田中 都

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

  5. 病原体センサーMincleを介する細胞間クロストークと脂肪組織線維化の分子機構

    Grant number:15K09423  2015.4 - 2018.3

    日本学術振興会  科学研究費 基盤研究(C)  基盤研究(C)

    田中 都

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

  6. 生体の栄養センサー・レプチンによる炎症免疫調節の分子機構

    Grant number:24790942  2012.4 - 2014.3

    日本学術振興会  科学研究費 若手研究(B)  若手研究(B)

    田中 都

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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Industrial property rights 1

  1. 薬剤投与デバイスの構造と製造法

    松元 亮、松本裕子、菅波孝祥、田中 都、宮原裕二

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    Applicant:東京医科歯科大学

    Application no:特願2015-209192  Date applied:2015.10

    Country of applicant:Domestic  

 

Teaching Experience (On-campus) 3

  1. 環境学入門

    2023

  2. 自然環境と人間

    2021

  3. 自然環境と人間

    2020

     詳細を見る

    免疫・代謝と疾患について,最新の情報を講義した

Teaching Experience (Off-campus) 3

  1. 内分泌・代謝学共同利用共同研究拠点セミナー

    2023.9 Gunma University)

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    Level:Other 

  2. 食品栄養科学月例セミナー

    2023.7 University of Shizuoka)

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    Level:Other 

  3. 器官生理学

    2022.10 Kanazawa University)

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    Country:Japan