Faculty Profiles - SUGANAMI Takayoshi

Papers - SUGANAMI Takayoshi

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Brain lipid profiles and oligodendrocyte gene expression show discordant responses to high-fat diet in Alzheimer's disease mice Open Access

Kawade, N; Komine, O; Sobue, A; Kakimi, C; Tanaka, M; Suganami, T; Shimada, M; Ogi, T; Ikeda, K; Horiuchi, M; Watanabe, S; Saito, T; Yamanaka, K

SCIENTIFIC REPORTS Vol. 16 ( 1 ) 2026.2

Genome-wide CRISPR-Cas9 screen identifies genes conferring Lenvatinib resistance in hepatocellular carcinoma

Zhou, S; Abe, Y; Isomura, H; Tanaka, M; Yamaguchi, R; Suganami, T; Taguchi, A

CANCER SCIENCE Vol. 117 page： 669 - 669 2026.1

Altered glycolipid metabolism during acute kidney injury exacerbates renal inflammation Open Access

Osada, A; Tanaka, M; Sugiura, Y; Yuan, XM; Yamashita, S; Ochi, K; Kohda, H; Ito, A; Go, S; Okajima, T; Kadomatsu, K; Yanagita, M; Furuhashi, K; Maruyama, S; Suganami, T

SCIENTIFIC REPORTS Vol. 16 ( 1 ) page： 147 2025.12

Glucose and insulin responses following streptozotocin administration for the induction of a type 1 diabetes mellitus model in Microminipig

Izumi, M; Hano, K; Kato, T; Hirata, A; Thaw, P; Seki, A; Tanaka, M; Ochi, K; Suganami, T; Kitagawa, H; Takasu, M

JOURNAL OF VETERINARY MEDICAL SCIENCE Vol. 87 ( 10 ) page： 1122 - 1127 2025.10

Potential effects of microglia-vascular interactions during chronic systemic inflammation in the central nervous system of mice with systemic lupus erythematosus

Shindo, M; Tsuji, T; Hartantyo, RY; Saito, Y; Ito, A; Sugio, S; Takeda, I; Suganami, T; Wake, H

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 87 ( 3 ) page： 509 - 520 2025.8

Transient Dietary Intervention Induces Healthy Adipose Tissue Expansion and Metabolically Healthy Obesity in Mice Open Access

Wada, E; Hosono, H; Tanaka, M; Miyakawa, F; Ochi, K; Kohda, H; Tanno, S; Shimano, R; Ito, A; Kitaura, Y; Ichihara, K; Matsumoto, A; Ogi, T; Satoh-Asahara, N; Murohara, T; Suganami, T

FASEB JOURNAL Vol. 39 ( 14 ) page： e70847 2025.7

Novel cell-to-cell communications between macrophages and fibroblasts regulate obesity-induced adipose tissue fibrosis. Invited Reviewed

Diabetes Vol. 74 ( 7 ) page： 1135 - 1152 2025.7

Lipid metabolism in myeloid cell function and chronic inflammatory diseases

Ito, A; Suganami, T

FRONTIERS IN IMMUNOLOGY Vol. 15 page： 1495853 2025.1

Genome-wide CRISPR-Cas9 screen for the identification of genes modulating lenvatinib resistance in HCC

Zhou, S; Abe, Y; Kajino, T; Isomura, H; Tanaka, M; Yamaguchi, R; Suganami, T; Taguchi, A

CANCER SCIENCE Vol. 116 page： 1363 - 1363 2025.1

Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis

Ishihara, T; Kato, K; Matsumoto, K; Tanaka, M; Hara, A; Shiraki, Y; Morisaki, H; Urano, Y; Ando, R; Ito, K; Mii, S; Esaki, N; Furuhashi, K; Takefuji, M; Suganami, T; Murohara, T; Enomoto, A

GENES TO CELLS Vol. 29 ( 10 ) page： 902 - 920 2024.10

Oya, M; Miyasaka, Y; Nakamura, Y; Tanaka, M; Suganami, T; Mashimo, T; Nakamura, K

CELL METABOLISM Vol. 36 ( 5 ) page： 1044 - 1058.e10 2024.5

Imeglimin Exhibits Novel Anti-Inflammatory Effects on High-Glucose-Stimulated Mouse Microglia through ULK1-Mediated Suppression of the TXNIP-NLRP3 Axis Open Access

Kato, H; Iwashita, K; Iwasa, M; Kato, S; Yamakage, H; Suganami, T; Tanaka, M; Satoh-Asahara, N

CELLS Vol. 13 ( 3 ) 2024.2

Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH Open Access

Itoh, M; Tamura, A; Kanai, S; Tanaka, M; Kanamori, Y; Shirakawa, I; Ito, A; Oka, Y; Hidaka, I; Takami, T; Honda, Y; Maeda, M; Saito, Y; Murata, Y; Matozaki, T; Nakajima, A; Kataoka, Y; Ogi, T; Ogawa, Y; Suganami, T

JOURNAL OF EXPERIMENTAL MEDICINE Vol. 220 ( 11 ) 2023.9

The new findings of disordered BCAA catabolism for metabolic disease

Wada, E; Suganami, T; Kitamura, T

ANNALS OF NUTRITION AND METABOLISM Vol. 79 page： 244 - 244 2023.8

Taxifolin Suppresses Inflammatory Responses of High-Glucose-Stimulated Mouse Microglia by Attenuating the TXNIP-NLRP3 Axis Open Access

Iwasa, M; Kato, H; Iwashita, K; Yamakage, H; Kato, S; Saito, S; Ihara, M; Nishimura, H; Kawamoto, A; Suganami, T; Tanaka, M; Satoh-Asahara, N

NUTRIENTS Vol. 15 ( 12 ) 2023.6

Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages Open Access

Shinoda, Y; Tatsukawa, H; Yonaga, A; Wakita, R; Takeuchi, T; Tsuji, T; Tanaka, M; Suganami, T; Hitomi, K

CELL DEATH & DISEASE Vol. 14 ( 2 ) page： 136 2023.3

Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84 Open Access

Ohue-Kitano, R; Nonaka, H; Nishida, A; Masujima, Y; Takahashi, D; Ikeda, T; Uwamizu, A; Tanaka, M; Kohjima, M; Igarashi, M; Katoh, H; Tanaka, T; Inoue, A; Suganami, T; Hase, K; Ogawa, Y; Aoki, J; Kimura, I

JCI INSIGHT Vol. 8 ( 2 ) 2023.1

Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis Open Access

Inoue, T; Fu, B; Nishio, M; Tanaka, M; Kato, H; Tanaka, M; Itoh, M; Yamakage, H; Ochi, K; Ito, A; Shiraki, Y; Saito, S; Ihara, M; Nishimura, H; Kawamoto, A; Inoue, S; Saeki, K; Enomoto, A; Suganami, T; Satoh-Asahara, N

NUTRIENTS Vol. 15 ( 2 ) 2023.1

Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome Open Access

Hachiya, R; Tanaka, M; Itoh, M; Suganami, T

INFLAMMATION AND REGENERATION Vol. 42 ( 1 ) page： 13 2022.5

FOXO1 cooperates with C/EBPδ and ATF4 to regulate skeletal muscle atrophy transcriptional program during fasting

Oyabu, M; Takigawa, K; Mizutani, S; Hatazawa, Y; Fujita, M; Ohira, Y; Sugimoto, T; Suzuki, O; Tsuchiya, K; Suganami, T; Ogawa, Y; Ishihara, K; Miura, S; Kamei, Y

FASEB JOURNAL Vol. 36 ( 2 ) page： e22152 2022.2

A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin Delivery Open Access

Chen, SY; Miyazaki, T; Itoh, M; Matsumoto, H; Moro-Oka, Y; Tanaka, M; Miyahara, Y; Suganami, T; Matsumoto, A

GELS Vol. 8 ( 2 ) 2022.2

Boronic Acid Ligands Can Target Multiple Subpopulations of Pancreatic Cancer Stem Cells via pH-Dependent Glycan-Terminal Sialic Acid Recognition

Miyazaki, T; Khan, T; Tachihara, Y; Itoh, M; Miyazawa, T; Suganami, T; Miyahara, Y; Cabral, H; Matsumoto, A

ACS APPLIED BIO MATERIALS Vol. 4 ( 9 ) page： 6647 - 6651 2021.9

The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model Open Access

Yoshioka, N; Tanaka, M; Ochi, K; Watanabe, A; Ono, K; Sawada, M; Ogi, T; Itoh, M; Ito, A; Shiraki, Y; Enomoto, A; Ishigami, M; Fujishiro, M; Ogawa, Y; Suganami, T

BIOMEDICINE & PHARMACOTHERAPY Vol. 140 page： 111738 2021.8

Role of chronic inflammation in the pathogenesis of nonalcoholic steatohepatitis: lessons from a unique mouse model using melanocortin receptor-deficient mice. Open Access

Itoh M, Suganami T, Ogawa Y

Endocrine journal Vol. 68 ( 7 ) page： 743 - 749 2021.7

Obesity accelerates hair thinning by stem cell-centric converging mechanisms Open Access

Morinaga, H; Mohri, Y; Grachtchouk, M; Asakawa, K; Matsumura, H; Oshima, M; Takayama, N; Kato, T; Nishimori, Y; Sorimachi, Y; Takubo, K; Suganami, T; Iwama, A; Iwakura, Y; Dlugosz, AA; Nishimura, EK

NATURE Vol. 595 ( 7866 ) page： 266 - + 2021.7

Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity Open Access

Kobayashi, A; Ito, A; Shirakawa, I; Tamura, A; Tomono, S; Shindou, H; Hedde, PN; Tanaka, M; Tsuboi, N; Ishimoto, T; Akashi-Takamura, S; Maruyama, S; Suganami, T

FRONTIERS IN IMMUNOLOGY Vol. 12 page： 650856 2021.6

Macrophages rely on extracellular serine to suppress aberrant cytokine production Open Access

Kurita, K; Ohta, H; Shirakawa, I; Tanaka, M; Kitaura, Y; Iwasaki, Y; Matsuzaka, T; Shimano, H; Aoe, S; Arima, H; Ogawa, Y; Ito, A; Suganami, T

SCIENTIFIC REPORTS Vol. 11 ( 1 ) page： 11137 2021.5

Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH Open Access

Kanamori, Y; Tanaka, M; Itoh, M; Ochi, K; Ito, A; Hidaka, I; Sakaida, I; Ogawa, Y; Suganami, T

ISCIENCE Vol. 24 ( 2 ) page： 102032 2021.2

Role of chronic inflammation in the pathogenesis of nonalcoholic steatohepatitis: lessons from a unique mouse model using melanocortin receptor-deficient mice

Itoh Michiko, Suganami Takayoshi, Ogawa Yoshihiro

ENDOCRINE JOURNAL Vol. 68 ( 7 ) page： 743 - 749 2021

Digenic mutations in <i>ALDH2</i> and <i>ADH5</i> impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome Open Access

Oka, Y; Hamada, M; Nakazawa, Y; Muramatsu, H; Okuno, Y; Higasa, K; Shimada, M; Takeshima, H; Hanada, K; Hirano, T; Kawakita, T; Sakaguchi, H; Ichimura, T; Ozono, S; Yuge, K; Watanabe, Y; Kotani, Y; Yamane, M; Kasugai, Y; Tanaka, M; Suganami, T; Nakada, S; Mitsutake, N; Hara, Y; Kato, K; Mizuno, S; Miyake, N; Kawai, Y; Tokunaga, K; Nagasaki, M; Kito, S; Isoyama, K; Onodera, M; Kaneko, H; Matsumoto, N; Matsuda, F; Matsuo, K; Takahashi, Y; Mashimo, T; Kojima, S; Ogi, T

SCIENCE ADVANCES Vol. 6 ( 51 ) 2020.12

C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury Open Access

Tanaka, M; Saka-Tanaka, M; Ochi, K; Fujieda, K; Sugiura, Y; Miyamoto, T; Kohda, H; Ito, A; Miyazawa, T; Matsumoto, A; Aoe, S; Miyamoto, Y; Tsuboi, N; Maruyama, S; Suematsu, M; Yamasaki, S; Ogawa, Y; Suganami, T

JOURNAL OF EXPERIMENTAL MEDICINE Vol. 217 ( 11 ) 2020.11

Blocking sphingosine 1-phosphate receptor 2 accelerates hepatocellular carcinoma progression in a mouse model of NASH

Yoshida, T; Tsuchiya, A; Kumagai, M; Takeuchi, S; Nojiri, S; Watanabe, T; Ogawa, M; Itoh, M; Takamura, M; Suganami, T; Ogawa, Y; Terai, S

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 530 ( 4 ) page： 665 - 672 2020.10

Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus Open Access

Fu, Y; Kaneko, K; Lin, HY; Mo, QX; Xu, Y; Suganami, T; Ravn, P; Fukuda, M

ENDOCRINOLOGY Vol. 161 ( 9 ) 2020.9

Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis: role of macrophages and fibroblasts in the liver Open Access

Itoh, M; Ogawa, Y; Suganami, T

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 82 ( 3 ) page： 391 - 397 2020.8

Temperature-Stable Boronate Gel-Based Microneedle Technology for Self-Regulated Insulin Delivery

Chen, SY; Miyazaki, T; Itoh, M; Matsumoto, H; Moro-oka, Y; Tanaka, M; Miyahara, Y; Suganami, T; Matsumoto, A

ACS APPLIED POLYMER MATERIALS Vol. 2 ( 7 ) page： 2781 - 2790 2020.7

Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system Open Access

Matsumoto, A; Kuwata, H; Kimura, S; Matsumoto, H; Ochi, K; Moro-oka, Y; Watanabe, A; Yamada, H; Ishii, H; Miyazawa, T; Chen, SY; Baba, T; Yoshida, H; Nakamura, T; Inoue, H; Ogawa, Y; Tanaka, M; Miyahara, Y; Suganami, T

COMMUNICATIONS BIOLOGY Vol. 3 ( 1 ) page： 313 2020.6

Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles

Watanabe Takayuki, Tsuchiya Atsunori, Takeuchi Suguru, Nojiri Shunsuke, Yoshida Tomoaki, Ogawa Masahiro, Itoh Michiko, Takamura Masaaki, Suganami Takayoshi, Ogawa Yoshihiro, Terai Shuji

REGENERATIVE THERAPY Vol. 14 page： 252 - 261 2020.6

Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles.

Watanabe T, Tsuchiya A, Takeuchi S, Nojiri S, Yoshida T, Ogawa M, Itoh M, Takamura M, Suganami T, Ogawa Y, Terai S

Regenerative therapy Vol. 14 page： 252 - 261 2020.6

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair Open Access

Nakazawa Yuka, Hara Yuichiro, Oka Yasuyoshi, Komine Okiru, van den Heuvel Diana, Guo Chaowan, Daigaku Yasukazu, Isono Mayu, He Yuxi, Shimada Mayuko, Kato Kana, Jia Nan, Hashimoto Satoru, Kotani Yuko, Miyoshi Yuka, Tanaka Miyako, Sobue Akira, Mitsutake Norisato, Suganami Takayoshi, Masuda Akio, Ohno Kinji, Nakada Shinichiro, Mashimo Tomoji, Yamanaka Koji, Luijsterburg Martijn S., Ogi Tomoo

CELL Vol. 180 ( 6 ) page： 1228 - + 2020.3

Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects. Open Access

Kawakubo M, Tanaka M, Ochi K, Watanabe A, Saka-Tanaka M, Kanamori Y, Yoshioka N, Yamashita S, Goto M, Itoh M, Shirakawa I, Kanai S, Suzuki H, Sawada M, Ito A, Ishigami M, Fujishiro M, Arima H, Ogawa Y, Suganami T

Scientific reports Vol. 10 ( 1 ) page： 983 2020.1

Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis Open Access

Asakawa Masahiro, Itoh Michiko, Suganami Takayoshi, Sakai Takeru, Kanai Sayaka, Shirakawa Ibuki, Yuan Xunmei, Hatayama Tomomi, Shimada Shu, Akiyama Yoshimitsu, Fujiu Katsuhito, Inagaki Yutaka, Manabe Ichiro, Yamaoka Shoji, Yamada Tetsuya, Tanaka Shinji, Ogawa Yoshihiro

SCIENTIFIC REPORTS Vol. 9 ( 1 ) page： 19601 2019.12

Smart Microneedle Fabricated with Silk Fibroin Combined Semi interpenetrating Network Hydrogel for Glucose-Responsive Insulin Delivery

Chen Siyuan, Matsumoto Hiroko, Moro-oka Yuki, Tanaka Miyako, Miyahara Yuji, Suganami Takayoshi, Matsumoto Akira

ACS BIOMATERIALS SCIENCE & ENGINEERING Vol. 5 ( 11 ) page： 5781 - 5789 2019.11

Evaluation of hepatic function using dynamic contrast-enhanced magnetic resonance imaging in melanocortin 4 receptor-deficient mice as a model of nonalcoholic steatohepatitis

Yamada Tomomi, Kashiwagi Yuto, Rokugawa Takemi, Kato Hideaki, Konishi Haruyo, Hamada Tadateru, Nagai Ryohei, Masago Yusaku, Itoh Michiko, Suganami Takayoshi, Ogawa Yoshihiro, Abe Kohji

MAGNETIC RESONANCE IMAGING Vol. 57 page： 210 - 217 2019.4

Microneedle-Array Patch Fabricated with Enzyme-Free Polymeric Components Capable of On-Demand Insulin Delivery

Chen Siyuan, Matsumoto Hiroko, Moro-oka Yuki, Tanaka Miyako, Miyahara Yuji, Suganami Takayoshi, Matsumoto Akira

ADVANCED FUNCTIONAL MATERIALS Vol. 29 ( 7 ) 2019.2

Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis Open Access

Goto Toshihiro, Itoh Michiko, Suganami Takayoshi, Kanai Sayaka, Shirakawa Ibuki, Sakai Takeru, Asakawa Masahiro, Yoneyama Toshihiro, Kai Toshihiro, Ogawa Yoshihiro

SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 8157 2018.5

Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intratumoral Hepatic Stellate Cells within Hepatocellular Carcinoma with Metabolic Risk Factors. Open Access

Chiyonobu N, Shimada S, Akiyama Y, Mogushi K, Itoh M, Akahoshi K, Matsumura S, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Suganami T, Yamaoka S, Ogawa Y, Tanabe M, Tanaka S

The American journal of pathology Vol. 188 ( 5 ) page： 1213 - 1224 2018.5

Molecular mechanism of obesity-induced 'metabolic' tissue remodeling. Open Access

Tanaka M, Itoh M, Ogawa Y, Suganami T

Journal of diabetes investigation Vol. 9 ( 2 ) page： 256 - 261 2018.3

Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH Open Access

Shiba Kumiko, Tsuchiya Kyoichiro, Komiya Chikara, Miyachi Yasutaka, Mori Kentaro, Shimazu Noriko, Yamaguchi Shinobu, Ogasawara Naomi, Katoh Makoto, Itoh Michiko, Suganami Takayoshi, Ogawa Yoshihiro

SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 2362 2018.2

CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis. Open Access

Itoh M, Suganami T, Kato H, Kanai S, Shirakawa I, Sakai T, Goto T, Asakawa M, Hidaka I, Sakugawa H, Ohnishi K, Komohara Y, Asano K, Sakaida I, Tanaka M, Ogawa Y

JCI insight Vol. 2 ( 22 ) 2017.11

Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice. Open Access

Matsumoto A, Tanaka M, Matsumoto H, Ochi K, Moro-Oka Y, Kuwata H, Yamada H, Shirakawa I, Miyazawa T, Ishii H, Kataoka K, Ogawa Y, Miyahara Y, Suganami T

Science advances Vol. 3 ( 11 ) page： eaaq0723 2017.11

Sphingosine 1-Phosphate (S1P) and its receptor S1PR2 regulate ductular reaction in a mouse model of nonalcoholic steatohepatitis

Kato, H; Itoh, M; Suganami, T; Nagai, R; Ishimoto, Y; Hashimoto, K; Morita, A; Yogo, E; Rokushima, M; Ogawa, Y

HEPATOLOGY Vol. 66 page： 1046A - 1047A 2017.10

Hepatocyte death-triggered CD11c-positive macrophage accumulation induces liver fibrosis in a murine model of non-alcoholic steatohepatitis

Itoh, M; Suganami, T; Kanai, S; Shirakawa, I; Sakai, T; Goto, T; Asakawa, M; Hidaka, I; Sakaida, I; Ogawa, Y

HEPATOLOGY Vol. 66 page： 1052A - 1052A 2017.10

The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages. Open Access

Nakajima A, Nakatani A, Hasegawa S, Irie J, Ozawa K, Tsujimoto G, Suganami T, Itoh H, Kimura I

PloS one Vol. 12 ( 7 ) page： e0179696 2017.7

WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice. Open Access

Takahashi D, Mori T, Sohara E, Tanaka M, Chiga M, Inoue Y, Nomura N, Zeniya M, Ochi H, Takeda S, Suganami T, Rai T, Uchida S

EBioMedicine Vol. 18 page： 118 - 127 2017.4

Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis. Open Access

Komiya C, Tanaka M, Tsuchiya K, Shimazu N, Mori K, Furuke S, Miyachi Y, Shiba K, Yamaguchi S, Ikeda K, Ochi K, Nakabayashi K, Hata KI, Itoh M, Suganami T, Ogawa Y

Scientific reports Vol. 7 page： 44754 2017.3

Inflammatory responses increase secretion of MD-1 protein. Open Access

Thomas Jennings R, Odkhuu E, Nakashima A, Morita N, Kobayashi T, Yamai I, Tanaka M, Suganami T, Haga S, Ozaki M, Watanabe Y, Nagai Y, Takatsu K, Kikuchi-Ueda T, Ichimonji I, Ogawa Y, Takagi H, Yamazaki T, Miyake K, Akashi-Takamura S

International immunology Vol. 28 ( 10 ) page： 503-512 2016.10

The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages. Open Access

Hachiya R, Shiihashi T, Shirakawa I, Iwasaki Y, Matsumura Y, Oishi Y, Nakayama Y, Miyamoto Y, Manabe I, Ochi K, Tanaka M, Goda N, Sakai J, Suganami T, Ogawa Y

Scientific reports Vol. 6 page： 28845 2016.6

Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice. Open Access

Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake K, Takatsu K

Scientific reports Vol. 6 page： 23097 2016.3

Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress. Open Access

Muramatsu-Kato K, Itoh H, Kohmura-Kobayashi Y, Ferdous UJ, Tamura N, Yaguchi C, Uchida T, Suzuki K, Hashimoto K, Suganami T, Ogawa Y, Kanayama N

Scientific reports Vol. 5 page： 16867 2015.11

Integration of transcriptome and methylome analysis of aldosterone-producing adenomas. Open Access

Murakami M, Yoshimoto T, Nakabayashi K, Tsuchiya K, Minami I, Bouchi R, Izumiyama H, Fujii Y, Abe K, Tayama C, Hashimoto K, Suganami T, Hata K, Kihara K, Ogawa Y

European journal of endocrinology Vol. 173 ( 2 ) page： 185-95 2015.8

Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using melanocortin 4 receptor-deficient mice. Open Access

Konuma K, Itoh M, Suganami T, Kanai S, Nakagawa N, Sakai T, Kawano H, Hara M, Kojima S, Izumi Y, Ogawa Y

PloS one Vol. 10 ( 3 ) page： e0121528 2015.3

Parenchymal-stromal cell interaction in metabolic diseases. Reviewed

Y. Ogawa, T. Suganami, M. Tanaka, M. Itoh.

Inflamm. Regen. Vol. 35 page： 167-171 2015

Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver.

T. Ehara, Y. Kamei, X. Yuan, M. Takahashi, S. Kanai, K. Tsujimoto, T. Tamiya, Y. Nakagawa, H. Shimano, T. Takai-Igarashi, I. Hatada, T. Suganami, K. Hashimoto, Y. Ogawa.

Diabetes Vol. 64 page： 775-784 2015

ATM regulates adipocyte differentiation and contributes to glucose homeostasis.

M. Takagi, H. Uno, R. Nishi, M. Sugimoto, S. Hasegwa, J. Piao, N. Ihara, S. Kanai, S. Kakei, Y. Tamura, T. Suganami, Y. Kamei, T. Shimizu, A. Yasuda, Y. Ogawa, S. Mizutani.

Cell Reports Vol. 10 page： 957-967 2015

Favine/CCDC3 is involved in lipid accumulation.

S. Kobayashi, A. Fukuhara, M. Otsuki, T. Suganami, Y. Ogawa, E. Morii, I. Shimomura.

J. Biol. Chem. Vol. 290 page： 7443-7451 2015

Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using Melanocortin 4 receptor-deficient mice. Reviewed

K. Konuma, M. Itoh, T. Suganami, S. Kanai, N. Nakagawa, T. Sakai, H. Kawano, M. Hara, S. Kojima, Y. Izumi, Y. Ogawa.

PLoS ONE Vol. 10 page： e0121528 2015

Integration of transcriptome and methylome analysis of aldosterone-producing adenomas. Open Access

M. Murakami, T. Yoshimoto, K. Nakabayashi, K. Tsuchiya, I. Minami, R. Bouchi, H. Izumiyama, Y. Fujii, K. Abe, C. Tayama, K. Hashimoto, T. Suganami, KI. Hata, K. Kihara, Y. Ogawa.

Eur. J. Endocrinol. Vol. 173 page： 185-195 2015

FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3'-UTR; possible contribution to ammonia detoxification. Open Access

Y. Kamei, M. Hattori, Y. Hatazawa, T. Kasahara, M. Kanou, S. Kanai, X. Yuan, T. Suganami, WH. Lamers, T. Kitamura, Y. Ogawa.

Am. J. Physiol. Vol. 307 page： E485-E493 2014

Increase in EPA/AA ratio associated with improved arterial stiffness in obese patients with dyslipidemia.

R. Ito, N. Satoh-Asahara, H. Yamakage, Y. Sasaki, S., Odori, S. Kono, H. Wada, T. Suganami, Y. Ogawa, K. Hasegawa, A. Shimatsu.

J. Atheroscler. Thromb. Vol. 21 page： 248-260 2014

Possible involvement of Opa-Interacting Protein 5 in adipose proliferation and obesity.

K. Inoue, N. Maeda, T. Mori, R. Sekimoto, Y. Tsushima, K. Matsuda, M. Yamaoka, T. Suganami, H. Nishizawa, Y. Ogawa, T. Funahashi, I. Shimomura.

PLoS ONE Vol. 9 page： e87661 2014

Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages. Reviewed

Y. Iwasaki, T. Suganami, R. Hachiya, I. Shirakawa, M. Kim-Saijo, M. Tanaka, M. Hamaguchi, T. Takai-Igarashi, M. Nakai, Y. Miyamoto, Y. Ogawa.

Diabetes Vol. 63 page： 152-161 2014

Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. Reviewed Open Access

M. Tanaka, K. Ikeda, T. Suganami, C. Komiya, K. Ochi, I. Shirakawa, M. Hamaguchi, S. Nishimura, I. Manabe, T. Matsuda, K. Kimura, H. Inoue, Y. Inagaki, S. Aoe, S. Yamasaki, Y. Ogawa.

Nat. Commun. Vol. 5 page： 4982 2014

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Papers - SUGANAMI Takayoshi