Nagoya University   Professor

2021.4

KISTEC

2019.4 - 2023.3

文部科学省・学術調査官（科研費担当）

2016.8 - 2018.7

Nagoya University   Professor

2015.7

Nagoya University   Professor

2015.7

東京医科歯科大学大学院医歯学総合研究科 臓器代謝ネットワーク講座・特任教授

2013.1 - 2015.6

科学技術振興機構　さきがけ研究者（兼任）

2012.10

東京医科歯科大学難治疾患研究所 分子代謝医学分野・准教授

2011.4 - 2012.12

東京医科歯科大学難治疾患研究所 分子代謝医学分野・助手

2003.5 - 2011.3

京都大学医学部附属病院 内分泌・代謝内科・医員

2001.11 - 2003.5

静岡県立総合病院・内科研修医

1995.5 - 1997.3

京都大学医学部附属病院・内科研修医

1994.5 - 1995.5

Nagoya University   Professor

日本肥満学会   評議員

日本心血管内分泌学会   理事、評議員

日本内分泌学会   理事、評議員

日本糖尿病学会

日本内科学会

日本臨床分子医学会   評議員

日本Cell Death学会   評議員

日本肥満学会 学術奨励賞

2011   日本肥満学会  

岡本研究奨励賞

2009   成人血管病研究振興財団  

CKD Award 2007 奨励賞

2007   CKD Award 2007  

2006 Werner Risau New Investigator Award in Vascular Biology

2006   Arteriosclerosis, Thrombosis, and Vascular Biology / American Heart Association  

日本内科学会 研究奨励賞

2006   日本内科学会  

日本肥満学会 若手研究奨励賞

2005   日本肥満学会  

日本臨床分子医学会 学術奨励賞

2005   日本臨床分子医学会  

分子腎臓研究会 優秀研究賞

2003   分子腎臓研究会  

日本心血管内分泌代謝学会 若手研究奨励賞

2003   日本心血管内分泌代謝学会  

日本内分泌学会 若手研究奨励賞

2002   日本内分泌学会  

Imeglimin Exhibits Novel Anti-Inflammatory Effects on High-Glucose-Stimulated Mouse Microglia through ULK1-Mediated Suppression of the TXNIP-NLRP3 Axis

Kato, H; Iwashita, K; Iwasa, M; Kato, S; Yamakage, H; Suganami, T; Tanaka, M; Satoh-Asahara, N

CELLS   Vol. 13 ( 3 )   2024.2

Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH

Itoh, M; Tamura, A; Kanai, S; Tanaka, M; Kanamori, Y; Shirakawa, I; Ito, A; Oka, Y; Hidaka, I; Takami, T; Honda, Y; Maeda, M; Saito, Y; Murata, Y; Matozaki, T; Nakajima, A; Kataoka, Y; Ogi, T; Ogawa, Y; Suganami, T

JOURNAL OF EXPERIMENTAL MEDICINE   Vol. 220 ( 11 )   2023.9

The new findings of disordered BCAA catabolism for metabolic disease

Wada, E; Suganami, T; Kitamura, T

ANNALS OF NUTRITION AND METABOLISM   Vol. 79   page： 244 - 244   2023.8

Taxifolin Suppresses Inflammatory Responses of High-Glucose-Stimulated Mouse Microglia by Attenuating the TXNIP-NLRP3 Axis

Iwasa, M; Kato, H; Iwashita, K; Yamakage, H; Kato, S; Saito, S; Ihara, M; Nishimura, H; Kawamoto, A; Suganami, T; Tanaka, M; Satoh-Asahara, N

NUTRIENTS   Vol. 15 ( 12 )   2023.6

Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages

Shinoda, Y; Tatsukawa, H; Yonaga, A; Wakita, R; Takeuchi, T; Tsuji, T; Tanaka, M; Suganami, T; Hitomi, K

CELL DEATH & DISEASE   Vol. 14 ( 2 ) page： 136   2023.3

Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84

Ohue-Kitano, R; Nonaka, H; Nishida, A; Masujima, Y; Takahashi, D; Ikeda, T; Uwamizu, A; Tanaka, M; Kohjima, M; Igarashi, M; Katoh, H; Tanaka, T; Inoue, A; Suganami, T; Hase, K; Ogawa, Y; Aoki, J; Kimura, I

JCI INSIGHT   Vol. 8 ( 2 )   2023.1

Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis

Inoue, T; Fu, B; Nishio, M; Tanaka, M; Kato, H; Tanaka, M; Itoh, M; Yamakage, H; Ochi, K; Ito, A; Shiraki, Y; Saito, S; Ihara, M; Nishimura, H; Kawamoto, A; Inoue, S; Saeki, K; Enomoto, A; Suganami, T; Satoh-Asahara, N

NUTRIENTS   Vol. 15 ( 2 )   2023.1

Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome

Hachiya, R; Tanaka, M; Itoh, M; Suganami, T

INFLAMMATION AND REGENERATION   Vol. 42 ( 1 ) page： 13   2022.5

A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin Delivery

Chen, SY; Miyazaki, T; Itoh, M; Matsumoto, H; Moro-Oka, Y; Tanaka, M; Miyahara, Y; Suganami, T; Matsumoto, A

GELS   Vol. 8 ( 2 )   2022.2

FOXO1 cooperates with C/EBPδ and ATF4 to regulate skeletal muscle atrophy transcriptional program during fasting

Oyabu, M; Takigawa, K; Mizutani, S; Hatazawa, Y; Fujita, M; Ohira, Y; Sugimoto, T; Suzuki, O; Tsuchiya, K; Suganami, T; Ogawa, Y; Ishihara, K; Miura, S; Kamei, Y

FASEB JOURNAL   Vol. 36 ( 2 ) page： e22152   2022.2

Boronic Acid Ligands Can Target Multiple Subpopulations of Pancreatic Cancer Stem Cells via pH-Dependent Glycan-Terminal Sialic Acid Recognition

Miyazaki, T; Khan, T; Tachihara, Y; Itoh, M; Miyazawa, T; Suganami, T; Miyahara, Y; Cabral, H; Matsumoto, A

ACS APPLIED BIO MATERIALS   Vol. 4 ( 9 ) page： 6647 - 6651   2021.9

The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model

Yoshioka, N; Tanaka, M; Ochi, K; Watanabe, A; Ono, K; Sawada, M; Ogi, T; Itoh, M; Ito, A; Shiraki, Y; Enomoto, A; Ishigami, M; Fujishiro, M; Ogawa, Y; Suganami, T

BIOMEDICINE & PHARMACOTHERAPY   Vol. 140   page： 111738   2021.8

Role of chronic inflammation in the pathogenesis of nonalcoholic steatohepatitis: lessons from a unique mouse model using melanocortin receptor-deficient mice.

Itoh M, Suganami T, Ogawa Y

Endocrine journal   Vol. 68 ( 7 ) page： 743 - 749   2021.7

Obesity accelerates hair thinning by stem cell-centric converging mechanisms

Morinaga, H; Mohri, Y; Grachtchouk, M; Asakawa, K; Matsumura, H; Oshima, M; Takayama, N; Kato, T; Nishimori, Y; Sorimachi, Y; Takubo, K; Suganami, T; Iwama, A; Iwakura, Y; Dlugosz, AA; Nishimura, EK

NATURE   Vol. 595 ( 7866 ) page： 266 - +   2021.7

Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity

Kobayashi, A; Ito, A; Shirakawa, I; Tamura, A; Tomono, S; Shindou, H; Hedde, PN; Tanaka, M; Tsuboi, N; Ishimoto, T; Akashi-Takamura, S; Maruyama, S; Suganami, T

FRONTIERS IN IMMUNOLOGY   Vol. 12   page： 650856   2021.6

Macrophages rely on extracellular serine to suppress aberrant cytokine production

Kurita, K; Ohta, H; Shirakawa, I; Tanaka, M; Kitaura, Y; Iwasaki, Y; Matsuzaka, T; Shimano, H; Aoe, S; Arima, H; Ogawa, Y; Ito, A; Suganami, T

SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 11137   2021.5

Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH

Kanamori, Y; Tanaka, M; Itoh, M; Ochi, K; Ito, A; Hidaka, I; Sakaida, I; Ogawa, Y; Suganami, T

ISCIENCE   Vol. 24 ( 2 ) page： 102032   2021.2

Role of chronic inflammation in the pathogenesis of nonalcoholic steatohepatitis: lessons from a unique mouse model using melanocortin receptor-deficient mice

Itoh Michiko, Suganami Takayoshi, Ogawa Yoshihiro

ENDOCRINE JOURNAL   Vol. 68 ( 7 ) page： 743 - 749   2021

Digenic mutations in <i>ALDH2</i> and <i>ADH5</i> impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome

Oka, Y; Hamada, M; Nakazawa, Y; Muramatsu, H; Okuno, Y; Higasa, K; Shimada, M; Takeshima, H; Hanada, K; Hirano, T; Kawakita, T; Sakaguchi, H; Ichimura, T; Ozono, S; Yuge, K; Watanabe, Y; Kotani, Y; Yamane, M; Kasugai, Y; Tanaka, M; Suganami, T; Nakada, S; Mitsutake, N; Hara, Y; Kato, K; Mizuno, S; Miyake, N; Kawai, Y; Tokunaga, K; Nagasaki, M; Kito, S; Isoyama, K; Onodera, M; Kaneko, H; Matsumoto, N; Matsuda, F; Matsuo, K; Takahashi, Y; Mashimo, T; Kojima, S; Ogi, T

SCIENCE ADVANCES   Vol. 6 ( 51 )   2020.12

C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury

Tanaka, M; Saka-Tanaka, M; Ochi, K; Fujieda, K; Sugiura, Y; Miyamoto, T; Kohda, H; Ito, A; Miyazawa, T; Matsumoto, A; Aoe, S; Miyamoto, Y; Tsuboi, N; Maruyama, S; Suematsu, M; Yamasaki, S; Ogawa, Y; Suganami, T

JOURNAL OF EXPERIMENTAL MEDICINE   Vol. 217 ( 11 )   2020.11

Blocking sphingosine 1-phosphate receptor 2 accelerates hepatocellular carcinoma progression in a mouse model of NASH

Yoshida, T; Tsuchiya, A; Kumagai, M; Takeuchi, S; Nojiri, S; Watanabe, T; Ogawa, M; Itoh, M; Takamura, M; Suganami, T; Ogawa, Y; Terai, S

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 530 ( 4 ) page： 665 - 672   2020.10

Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus

Fu, Y; Kaneko, K; Lin, HY; Mo, QX; Xu, Y; Suganami, T; Ravn, P; Fukuda, M

ENDOCRINOLOGY   Vol. 161 ( 9 )   2020.9

Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis: role of macrophages and fibroblasts in the liver

Itoh, M; Ogawa, Y; Suganami, T

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 3 ) page： 391 - 397   2020.8

Temperature-Stable Boronate Gel-Based Microneedle Technology for Self-Regulated Insulin Delivery

Chen, SY; Miyazaki, T; Itoh, M; Matsumoto, H; Moro-oka, Y; Tanaka, M; Miyahara, Y; Suganami, T; Matsumoto, A

ACS APPLIED POLYMER MATERIALS   Vol. 2 ( 7 ) page： 2781 - 2790   2020.7

Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system

Matsumoto, A; Kuwata, H; Kimura, S; Matsumoto, H; Ochi, K; Moro-oka, Y; Watanabe, A; Yamada, H; Ishii, H; Miyazawa, T; Chen, SY; Baba, T; Yoshida, H; Nakamura, T; Inoue, H; Ogawa, Y; Tanaka, M; Miyahara, Y; Suganami, T

COMMUNICATIONS BIOLOGY   Vol. 3 ( 1 ) page： 313   2020.6

Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles

Watanabe Takayuki, Tsuchiya Atsunori, Takeuchi Suguru, Nojiri Shunsuke, Yoshida Tomoaki, Ogawa Masahiro, Itoh Michiko, Takamura Masaaki, Suganami Takayoshi, Ogawa Yoshihiro, Terai Shuji

REGENERATIVE THERAPY   Vol. 14   page： 252 - 261   2020.6

Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles.

Watanabe T, Tsuchiya A, Takeuchi S, Nojiri S, Yoshida T, Ogawa M, Itoh M, Takamura M, Suganami T, Ogawa Y, Terai S

Regenerative therapy   Vol. 14   page： 252 - 261   2020.6

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

Nakazawa Yuka, Hara Yuichiro, Oka Yasuyoshi, Komine Okiru, van den Heuvel Diana, Guo Chaowan, Daigaku Yasukazu, Isono Mayu, He Yuxi, Shimada Mayuko, Kato Kana, Jia Nan, Hashimoto Satoru, Kotani Yuko, Miyoshi Yuka, Tanaka Miyako, Sobue Akira, Mitsutake Norisato, Suganami Takayoshi, Masuda Akio, Ohno Kinji, Nakada Shinichiro, Mashimo Tomoji, Yamanaka Koji, Luijsterburg Martijn S., Ogi Tomoo

CELL   Vol. 180 ( 6 ) page： 1228 - +   2020.3

Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects.

Kawakubo M, Tanaka M, Ochi K, Watanabe A, Saka-Tanaka M, Kanamori Y, Yoshioka N, Yamashita S, Goto M, Itoh M, Shirakawa I, Kanai S, Suzuki H, Sawada M, Ito A, Ishigami M, Fujishiro M, Arima H, Ogawa Y, Suganami T

Scientific reports   Vol. 10 ( 1 ) page： 983   2020.1

Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis

Asakawa Masahiro, Itoh Michiko, Suganami Takayoshi, Sakai Takeru, Kanai Sayaka, Shirakawa Ibuki, Yuan Xunmei, Hatayama Tomomi, Shimada Shu, Akiyama Yoshimitsu, Fujiu Katsuhito, Inagaki Yutaka, Manabe Ichiro, Yamaoka Shoji, Yamada Tetsuya, Tanaka Shinji, Ogawa Yoshihiro

SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page： 19601   2019.12

Smart Microneedle Fabricated with Silk Fibroin Combined Semi interpenetrating Network Hydrogel for Glucose-Responsive Insulin Delivery

Chen Siyuan, Matsumoto Hiroko, Moro-oka Yuki, Tanaka Miyako, Miyahara Yuji, Suganami Takayoshi, Matsumoto Akira

ACS BIOMATERIALS SCIENCE & ENGINEERING   Vol. 5 ( 11 ) page： 5781 - 5789   2019.11

Evaluation of hepatic function using dynamic contrast-enhanced magnetic resonance imaging in melanocortin 4 receptor-deficient mice as a model of nonalcoholic steatohepatitis

Yamada Tomomi, Kashiwagi Yuto, Rokugawa Takemi, Kato Hideaki, Konishi Haruyo, Hamada Tadateru, Nagai Ryohei, Masago Yusaku, Itoh Michiko, Suganami Takayoshi, Ogawa Yoshihiro, Abe Kohji

MAGNETIC RESONANCE IMAGING   Vol. 57   page： 210 - 217   2019.4

Microneedle-Array Patch Fabricated with Enzyme-Free Polymeric Components Capable of On-Demand Insulin Delivery

Chen Siyuan, Matsumoto Hiroko, Moro-oka Yuki, Tanaka Miyako, Miyahara Yuji, Suganami Takayoshi, Matsumoto Akira

ADVANCED FUNCTIONAL MATERIALS   Vol. 29 ( 7 )   2019.2

Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis

Goto Toshihiro, Itoh Michiko, Suganami Takayoshi, Kanai Sayaka, Shirakawa Ibuki, Sakai Takeru, Asakawa Masahiro, Yoneyama Toshihiro, Kai Toshihiro, Ogawa Yoshihiro

SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page： 8157   2018.5

Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intratumoral Hepatic Stellate Cells within Hepatocellular Carcinoma with Metabolic Risk Factors.

Chiyonobu N, Shimada S, Akiyama Y, Mogushi K, Itoh M, Akahoshi K, Matsumura S, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Suganami T, Yamaoka S, Ogawa Y, Tanabe M, Tanaka S

The American journal of pathology   Vol. 188 ( 5 ) page： 1213 - 1224   2018.5

Molecular mechanism of obesity-induced 'metabolic' tissue remodeling.

Tanaka M, Itoh M, Ogawa Y, Suganami T

Journal of diabetes investigation   Vol. 9 ( 2 ) page： 256 - 261   2018.3

Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH

Shiba Kumiko, Tsuchiya Kyoichiro, Komiya Chikara, Miyachi Yasutaka, Mori Kentaro, Shimazu Noriko, Yamaguchi Shinobu, Ogasawara Naomi, Katoh Makoto, Itoh Michiko, Suganami Takayoshi, Ogawa Yoshihiro

SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page： 2362   2018.2

CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis.

Itoh M, Suganami T, Kato H, Kanai S, Shirakawa I, Sakai T, Goto T, Asakawa M, Hidaka I, Sakugawa H, Ohnishi K, Komohara Y, Asano K, Sakaida I, Tanaka M, Ogawa Y

JCI insight   Vol. 2 ( 22 )   2017.11

Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice.

Matsumoto A, Tanaka M, Matsumoto H, Ochi K, Moro-Oka Y, Kuwata H, Yamada H, Shirakawa I, Miyazawa T, Ishii H, Kataoka K, Ogawa Y, Miyahara Y, Suganami T

Science advances   Vol. 3 ( 11 ) page： eaaq0723   2017.11

Sphingosine 1-Phosphate (S1P) and its receptor S1PR2 regulate ductular reaction in a mouse model of nonalcoholic steatohepatitis

Kato, H; Itoh, M; Suganami, T; Nagai, R; Ishimoto, Y; Hashimoto, K; Morita, A; Yogo, E; Rokushima, M; Ogawa, Y

HEPATOLOGY   Vol. 66   page： 1046A - 1047A   2017.10

Hepatocyte death-triggered CD11c-positive macrophage accumulation induces liver fibrosis in a murine model of non-alcoholic steatohepatitis

Itoh, M; Suganami, T; Kanai, S; Shirakawa, I; Sakai, T; Goto, T; Asakawa, M; Hidaka, I; Sakaida, I; Ogawa, Y

HEPATOLOGY   Vol. 66   page： 1052A - 1052A   2017.10

The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages.

Nakajima A, Nakatani A, Hasegawa S, Irie J, Ozawa K, Tsujimoto G, Suganami T, Itoh H, Kimura I

PloS one   Vol. 12 ( 7 ) page： e0179696   2017.7

WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice.

Takahashi D, Mori T, Sohara E, Tanaka M, Chiga M, Inoue Y, Nomura N, Zeniya M, Ochi H, Takeda S, Suganami T, Rai T, Uchida S

EBioMedicine   Vol. 18   page： 118 - 127   2017.4

Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis.

Komiya C, Tanaka M, Tsuchiya K, Shimazu N, Mori K, Furuke S, Miyachi Y, Shiba K, Yamaguchi S, Ikeda K, Ochi K, Nakabayashi K, Hata KI, Itoh M, Suganami T, Ogawa Y

Scientific reports   Vol. 7   page： 44754   2017.3

Inflammatory responses increase secretion of MD-1 protein.

Thomas Jennings R, Odkhuu E, Nakashima A, Morita N, Kobayashi T, Yamai I, Tanaka M, Suganami T, Haga S, Ozaki M, Watanabe Y, Nagai Y, Takatsu K, Kikuchi-Ueda T, Ichimonji I, Ogawa Y, Takagi H, Yamazaki T, Miyake K, Akashi-Takamura S

International immunology   Vol. 28 ( 10 ) page： 503-512   2016.10

The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages.

Hachiya R, Shiihashi T, Shirakawa I, Iwasaki Y, Matsumura Y, Oishi Y, Nakayama Y, Miyamoto Y, Manabe I, Ochi K, Tanaka M, Goda N, Sakai J, Suganami T, Ogawa Y

Scientific reports   Vol. 6   page： 28845   2016.6

Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice.

Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake K, Takatsu K

Scientific reports   Vol. 6   page： 23097   2016.3

Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress.

Muramatsu-Kato K, Itoh H, Kohmura-Kobayashi Y, Ferdous UJ, Tamura N, Yaguchi C, Uchida T, Suzuki K, Hashimoto K, Suganami T, Ogawa Y, Kanayama N

Scientific reports   Vol. 5   page： 16867   2015.11

Integration of transcriptome and methylome analysis of aldosterone-producing adenomas.

Murakami M, Yoshimoto T, Nakabayashi K, Tsuchiya K, Minami I, Bouchi R, Izumiyama H, Fujii Y, Abe K, Tayama C, Hashimoto K, Suganami T, Hata K, Kihara K, Ogawa Y

European journal of endocrinology   Vol. 173 ( 2 ) page： 185-95   2015.8

Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using melanocortin 4 receptor-deficient mice.

Konuma K, Itoh M, Suganami T, Kanai S, Nakagawa N, Sakai T, Kawano H, Hara M, Kojima S, Izumi Y, Ogawa Y

PloS one   Vol. 10 ( 3 ) page： e0121528   2015.3

Parenchymal-stromal cell interaction in metabolic diseases. Reviewed

Y. Ogawa, T. Suganami, M. Tanaka, M. Itoh.

Inflamm. Regen.   Vol. 35   page： 167-171   2015

Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver.

T. Ehara, Y. Kamei, X. Yuan, M. Takahashi, S. Kanai, K. Tsujimoto, T. Tamiya, Y. Nakagawa, H. Shimano, T. Takai-Igarashi, I. Hatada, T. Suganami, K. Hashimoto, Y. Ogawa.

Diabetes   Vol. 64   page： 775-784   2015

ATM regulates adipocyte differentiation and contributes to glucose homeostasis.

M. Takagi, H. Uno, R. Nishi, M. Sugimoto, S. Hasegwa, J. Piao, N. Ihara, S. Kanai, S. Kakei, Y. Tamura, T. Suganami, Y. Kamei, T. Shimizu, A. Yasuda, Y. Ogawa, S. Mizutani.

Cell Reports   Vol. 10   page： 957-967   2015

Favine/CCDC3 is involved in lipid accumulation.

S. Kobayashi, A. Fukuhara, M. Otsuki, T. Suganami, Y. Ogawa, E. Morii, I. Shimomura.

J. Biol. Chem.   Vol. 290   page： 7443-7451   2015

Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using Melanocortin 4 receptor-deficient mice. Reviewed

K. Konuma, M. Itoh, T. Suganami, S. Kanai, N. Nakagawa, T. Sakai, H. Kawano, M. Hara, S. Kojima, Y. Izumi, Y. Ogawa.

PLoS ONE   Vol. 10   page： e0121528   2015

Integration of transcriptome and methylome analysis of aldosterone-producing adenomas.

M. Murakami, T. Yoshimoto, K. Nakabayashi, K. Tsuchiya, I. Minami, R. Bouchi, H. Izumiyama, Y. Fujii, K. Abe, C. Tayama, K. Hashimoto, T. Suganami, KI. Hata, K. Kihara, Y. Ogawa.

Eur. J. Endocrinol.   Vol. 173   page： 185-195   2015

Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. Reviewed

M. Tanaka, K. Ikeda, T. Suganami, C. Komiya, K. Ochi, I. Shirakawa, M. Hamaguchi, S. Nishimura, I. Manabe, T. Matsuda, K. Kimura, H. Inoue, Y. Inagaki, S. Aoe, S. Yamasaki, Y. Ogawa.

Nat. Commun.   Vol. 5   page： 4982   2014

FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3'-UTR; possible contribution to ammonia detoxification.

Y. Kamei, M. Hattori, Y. Hatazawa, T. Kasahara, M. Kanou, S. Kanai, X. Yuan, T. Suganami, WH. Lamers, T. Kitamura, Y. Ogawa.

Am. J. Physiol.   Vol. 307   page： E485-E493   2014

Increase in EPA/AA ratio associated with improved arterial stiffness in obese patients with dyslipidemia.

R. Ito, N. Satoh-Asahara, H. Yamakage, Y. Sasaki, S., Odori, S. Kono, H. Wada, T. Suganami, Y. Ogawa, K. Hasegawa, A. Shimatsu.

J. Atheroscler. Thromb.   Vol. 21   page： 248-260   2014

Possible involvement of Opa-Interacting Protein 5 in adipose proliferation and obesity.

K. Inoue, N. Maeda, T. Mori, R. Sekimoto, Y. Tsushima, K. Matsuda, M. Yamaoka, T. Suganami, H. Nishizawa, Y. Ogawa, T. Funahashi, I. Shimomura.

PLoS ONE   Vol. 9   page： e87661   2014

Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages. Reviewed

Y. Iwasaki, T. Suganami, R. Hachiya, I. Shirakawa, M. Kim-Saijo, M. Tanaka, M. Hamaguchi, T. Takai-Igarashi, M. Nakai, Y. Miyamoto, Y. Ogawa.

Diabetes   Vol. 63   page： 152-161   2014

「見る脂質のページ：イメージングと細胞解析でみるイムノメタボリズム」（企画）

The Lipid. メディカルレビュー社 

もっとよくわかる！　線維化と疾患

（ Role： Edit）

羊土社 

細胞内脂質代謝による免疫代謝と慢性炎症性疾患

（ Role： Joint author）

実験医学増刊「栄養・代謝物シグナルと食品機能」、羊土社 

死細胞由来リガンドによるマクロファージ活性化

（ Role： Joint author）

実験医学増刊「シン・マクロファージ」、羊土社 

細胞死と脂質、代謝性疾患

（ Role： Joint author）

実験医学増刊「脂質疾患学」、羊土社 

Molecular mechanism underlying cell death-triggered chronic inflammation in the metabolic syndrome

日本分子生物学会年会2021 

スマートインスリン

第56回日本糖尿病学会・糖尿病学の進歩 

細胞死が駆動する炎症慢性化機構と生活習慣病 Invited

菅波孝祥

第28回エンドトキシン・自然免疫研究会  2023 

脂肪肝・NASHにおける生命金属動態の破綻と肝線維化における意義 Invited

菅波孝祥

第96回日本生化学会大会・シンポジウム  2023 

肥満は万病の元！？　脂肪との正しい付き合い方 Invited

菅波孝祥

第38回生体防御学会学術集会・市民公開講座  2023 

スマートインスリンデバイスの研究開発；「貼るだけで血糖コントロール」の実現を目指して Invited

菅波孝祥

第66回日本糖尿病学会年次学術集会  2023 

減量中の大豆たん白摂取が脂肪組織炎症に及ぼす影響

2023.4 - 2024.3

不二たん白質研究振興財団 

貼るだけで自律的にインスリンを放出制御するマイクロニードルデバイスの開発

2023.4 - 2024.3

日本糖尿病財団サノフィ研究助成 

減量中のリバウンドが脂肪組織の慢性炎症と分岐鎖アミノ酸代謝に及ぼす影響と肥満治療への応用

2023

糧食研究会 

菅波孝祥

超分子医薬による肝線維症に対する先制医療の実現

2022.4 - 2026.3

住友電工グループ社会貢献基金大学講座寄付 

死細胞の脂質代謝変容がもたらす新たな炎症慢性化機構の解明

2021.4

小野医学研究財団 

貼るだけで自律的にインスリンを放出制御する”スマート”インスリンデバイスの開発

2021.4

鈴木謙三記念医科学応用研究財団 

加齢による皮下脂肪萎縮の分子基盤の解明

2021.4

コーセーコスメトロジー研究財団 

上原記念生命科学財団

2020

大幸財団

2020

大幸財団 

小林財団

2020

小林財団 

腎臓病において組織障害と修復を制御する微小環境の解明と医学応用

2019.10 - 2025.3

革新的先端研究開発支援事業・AMED-CREST 

武田科学振興財団

2019.10 - 2022.9

学内共同研究 

堀科学芸術振興財団

2019.1 - 2021.12

学内共同研究 

ノバルティス科学振興財団

2019.1 - 2019.12

学内共同研究 

日本糖尿病財団

2018.1 - 2018.12

学内共同研究 

肝臓脂肪量減少作用をもつ緑豆タンパクの新規な抗生活習慣病機能性食材として実用化への取り組み

2016.10 - 2020.3

研究成果最適展開支援プログラム 

金沢大学　井上啓

代謝異常治療研究基金

2016

国内共同研究 

セコム科学技術振興財団

2016

国内共同研究 

次世代型の人工膵臓による革新的な糖尿病治療機器の開発

2015.10 - 2018.3

産学連携医療イノベーション創出プログラム 

鈴木謙三記念医科学応用研究財団

2015

国内共同研究 

上原記念生命科学財団

2015

国内共同研究 

第一三共生命科学研究振興財団

2015

国内共同研究 

糖尿病患者のQOL(生活の質)向上を目指したエレクトロニクスフリーな人工膵臓の開発

2014.12 - 2017.3

大学発新産業創出プログラム 

代謝ストレスによる炎症の慢性化機構の解明

2012.10 - 2016.3

戦略的創造研究推進事業 さきがけ 

マクロファージの細胞内鉄代謝変容がもたらす肝線維化機構の解明

Grant number：22H04806  2022.4 - 2024.3

科学研究費助成事業  新学術領域研究(研究領域提案型)

菅波 孝祥

The spatiotemporal dynamics of microglia in the excessive nutrition induced hypothalamic inflammation

Grant number：20K07355  2020.4 - 2024.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Fu Yukiko

Molecular mechanism of cell death-induced tissue remodeling in metabolic syndrome

Grant number：20H03447  2020.4 - 2023.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Suganami Takayoshi

Role of Mincle in the regulation of Inflammation Cellular Sociology

Grant number：20H04944  2020.4 - 2022.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Iron metabolism in immune cells and liver fibrosis

Grant number：20H05503  2020.4 - 2022.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Immune cell lipid reprogramming in chronic inflammatory diseases

Grant number：19KK0249  2019.10 - 2024.3

Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Ito Ayaka

Mechanism of progression of dementia and sarcopenia through gut-brain-muscle linkage mediated by monocytes and microglia

Grant number：18K19769  2018.6 - 2022.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

Satoh-Asahara Noriko

ダイイングコードによる組織破壊・修復バランスの制御機構の解明

Grant number：17H05500  2017.4 - 2019.3

新学術領域研究(研究領域提案型)

菅波 孝祥

Role of the crosstalk between liver and brain in the pathophysiology of liver fibrosis

Grant number：16KT0110  2016.7 - 2019.3

Suganami Takayoshi

Role of "metabolic" tissue remodeling in the pathophysiology of obesity-induced chronic inflammation

Grant number：16H05171  2016.4 - 2019.3

Suganami Takayoshi

Role of amino acid metabolism in the regulation of inflammation

Grant number：16K15234  2016.4 - 2018.3

Suganami Takayoshi

アミノ酸代謝リモデリングによる新たな炎症制御機構の解明

2016.4 - 2017.3

科学研究費補助金  挑戦的萌芽研究

菅波　孝祥

代謝性組織リモデリングとその変容によるメタボリックシンドロームの分子機構の解明

2016.4 - 2017.3

科学研究費補助金  基盤研究(B)

菅波　孝祥

Development of Novel Diagnostic Markers and Treatment Strategies for Obese/Diabetic Complications through Targeting Bone Marrow Monocytes-related Molecules

Grant number：15K08634  2015.4 - 2018.3

Satoh-Asahara Noriko

組織の修復と破壊を促進するダイイングコードの解明

2015.4 - 2017.3

科学研究費補助金  新学術領域研究

新しいモデル動物を用いたNASH発症の分子機構の解明

2013.4 - 2015.3

科学研究費補助金  新学術領域研究

リン脂質代謝を介する腎障害の新たな分子機構の解明

2013.4 - 2015.3

科学研究費補助金  挑戦的萌芽研究

新しい非アルコール性脂肪性肝炎モデルを用いた異所性脂肪蓄積の分子機構の解明

2011.4 - 2013.3

科学研究費補助金  新学術領域研究

新規病原体センサー・内因性リガンド系が織りなす急性腎不全の新たな制御機構の解明

2011.4 - 2013.3

科学研究費補助金  挑戦的萌芽研究

メタボリックシンドロームにおける遊離脂肪酸ダイナミズムの分子機構の解明

2009.4 - 2012.3

科学研究費補助金  若手研究(A)

生体における脂肪細胞の起源と生理的脂肪細胞新生の分子機構の解明

2009.4 - 2011.3

科学研究費補助金  挑戦的萌芽研究

中枢神経系を介した臓器間クロストークによる腎障害進展の分子機構の解明

2007.4 - 2009.3

科学研究費補助金 

炎症性メディエータとしての遊離脂肪酸の分子機構の解明と医学応用

2006.4 - 2009.3

科学研究費補助金  若手研究(A)

脂肪細胞の増殖・分化における局所調節因子としてのアンジオテンシンⅡの分子機構

2004.4 - 2006.3

科学研究費補助金  若手研究(B)

発生工学的手法を用いた蛋白尿発症の分子機構解明と新しい腎炎・腎症治療法の開発

2002.4 - 2003.3

科学研究費補助金  若手研究(B)

非アルコール性脂肪肝炎モデル動物の製造方法

菅波孝祥、伊藤美智子、小川佳宏

インスリン送達用デバイス

松本　亮、松本裕子、菅波孝祥、宮原裕二

脂肪細胞の炎症性変化を抑制する物質のスクリーニング系及びそれを用いたスクリーニング

小川佳宏、菅波孝祥

生理学・エネルギー代謝

2022

生化学・代謝調節のまとめ

2022

生理学・エネルギー代謝

2021

選択特別講義・生活習慣病

2021

生化学・代謝調節のまとめ

2021

選択特別講義・生活習慣病

2020

生理学・エネルギー代謝

2020

生化学・代謝調節のまとめ

2020

教養・自然環境と人間

2019

選択特別講義・生活習慣病

2019

生理学・エネルギー代謝

2019

生化学・代謝調節のまとめ

2019

教養・自然環境と人間

2018

選択特別講義・生活習慣病

2018

生理学・エネルギー代謝

2018

生化学・代謝調節のまとめ

2018

教養・自然環境と人間

2017

生化学・代謝調節のまとめ

2017

生理学・エネルギー代謝

2017

選択特別講義・生活習慣病

2017

生理学・エネルギー代謝

2016

選択特別講義・生活習慣病

2016