2024/03/11 更新

写真a

ヤナギサワ サトシ
柳澤 哲
YANAGISAWA Satoshi
所属
大学院医学系研究科 先進循環器治療学寄附講座 特任講師
職名
特任講師

学位 1

  1. 博士(医学) ( 2017年1月   名古屋大学 ) 

研究分野 1

  1. ライフサイエンス / 循環器内科学  / 不整脈学、電気生理学

所属学協会 3

  1. 日本不整脈心電学会

  2. 日本内科学会

  3. 日本循環器学会

委員歴 2

  1. 日本内科学会東海支部 評議員  

  2. 日本不整脈心電学会 第3期評議員  

 

論文 81

  1. Periprocedural Management of Cardiac Tamponade During Catheter Ablation for AF Under Uninterrupted DOAC and Warfarin

    Yanagisawa S.

    JACC: Clinical Electrophysiology     2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jacep.2020.02.005

    Scopus

  2. Prothrombotic Responses After Catheter Ablation for Atrial Fibrillation During Uninterrupted Oral Anticoagulant Agent Administration.

      5 巻 ( 12 ) 頁: 1418-1427   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jacep.2019.09.002

    Scopus

    PubMed

  3. Distributions and number of drivers on real-time phase mapping associated with successful atrial fibrillation termination during catheter ablation for non-paroxysmal atrial fibrillation.

    Riku S, Inden Y, Yanagisawa S, Fujii A, Tomomatsu T, Nakagomi T, Shimojo M, Okajima T, Furui K, Suga K, Suzuki S, Shibata R, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   67 巻 ( 2 ) 頁: 303 - 317   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10840-023-01588-8

    PubMed

  4. Comparison of novel intrinsic versus conventional antitachycardia pacing for ventricular tachycardia among implantable cardioverter-defibrillator recipients.

    Yanagisawa S, Inden Y, Sato Y, Watanabe R, Goto T, Kondo S, Tachi M, Iwawaki T, Yamauchi R, Hiramatsu K, Shimojo M, Tsuji Y, Shibata R, Murohara T

    Journal of cardiovascular electrophysiology     2024年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jce.16232

    PubMed

  5. Editorial to "pseudo-slow-fast atrioventricular nodal reentrant tachycardia: Is the fast pathway a criminal or innocent bystander?".

    Mizutani Y, Yanagisawa S, Inden Y

    Journal of arrhythmia   40 巻 ( 1 ) 頁: 146 - 147   2024年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/joa3.12978

    PubMed

  6. Reply: Methodological and Mechanistic Considerations in Local Repolarization Mapping.

    Yanagisawa S, Inden Y, Tsuji Y, Shibata R, Murohara T

    JACC. Clinical electrophysiology   10 巻 ( 2 ) 頁: 378   2024年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jacep.2024.01.009

    PubMed

  7. Usefulness of omnipolar technology near field for accessory pathway ablation through the coronary sinus.

    Mizutani Y, Yanagisawa S, Matsumoto Y, Kanashiro M, Inden Y, Murohara T

    HeartRhythm case reports   10 巻 ( 1 ) 頁: 92 - 95   2024年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.hrcr.2023.10.030

    PubMed

  8. Clinical outcomes and predictors of delayed echocardiographic response to cardiac resynchronization therapy.

    Tsurumi N, Inden Y, Yanagisawa S, Hiramatsu K, Yamauchi R, Watanabe R, Suzuki N, Shimojo M, Suga K, Tsuji Y, Murohara T

    Journal of cardiovascular electrophysiology   35 巻 ( 1 ) 頁: 97 - 110   2024年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jce.16125

    PubMed

  9. Association Between Catheter Ablation for Nonparoxysmal Atrial Fibrillation and Functional Mitral Regurgitation in Patients With Heart Failure With Preserved Ejection Fraction.

    Yamauchi R, Morishima I, Okumura K, Kanzaki Y, Morita Y, Watanabe N, Furui K, Yoshioka N, Shibata N, Miyazawa H, Shimojo K, Imaoka T, Sakamoto G, Goto H, Ohi T, Yanagisawa S, Inden Y, Murohara T

    The American journal of cardiology   207 巻   頁: 192 - 201   2023年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.amjcard.2023.08.154

    PubMed

  10. Visualization of Repolarization Heterogeneity in Brugada Syndrome: A Quantitative Analysis of Unipolar Electrogram T-Wave.

    Yanagisawa S, Inden Y, Goto T, Kondo S, Tachi M, Iwawaki T, Hiramatsu K, Yamauchi R, Shimojo M, Tsuji Y, Shibata R, Murohara T

    JACC. Clinical electrophysiology   9 巻 ( 11 ) 頁: 2401 - 2411   2023年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jacep.2023.08.010

    PubMed

  11. Elevated liver fibrosis-4 index predicts recurrence after catheter ablation for atrial fibrillation in patients with heart failure.

    Iwawaki T, Morishima I, Kanzaki Y, Morita Y, Watanabe N, Yoshioka N, Shibata N, Miyazawa H, Shimojo K, Yanagisawa S, Inden Y, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing     2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10840-023-01661-2

    PubMed

  12. Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads.

    Perino AC, Wang PJ, Lloyd M, Zanon F, Fujiu K, Osman F, Briongos-Figuero S, Sato T, Aksu T, Jastrzebski M, Sideris S, Rao P, Boczar K, Yuan-Ning X, Wu M, Namboodiri N, Garcia R, Kataria V, De Pooter J, Przibille O, Gehi AK, Cano O, Katsouras G, Cai B, Astheimer K, Tanawuttiwat T, Datino T, Rizkallah J, Alasti M, Feld G, Barrio-Lopez MT, Gilmore M, Conti S, Yanagisawa S, Indik JH, Zou J, Saha SA, Rodriguez-Munoz D, Chang KC, Lebedev DS, Leal MA, Haeberlin A, Forno ARJD, Orlov M, Frutos M, Cabanas-Grandio P, Lyne J, Leyva F, Tolosana JM, Ollitrault P, Vergara P, Balla C, Devabhaktuni SR, Forleo G, Letsas KP, Verma A, Moak JP, Shelke AB, Curila K, Cronin EM, Futyma P, Wan EY, Lazzerini PE, Bisbal F, Casella M, Turitto G, Rosenthal L, Bunch TJ, Baszko A, Clementy N, Cha YM, Chen HC, Galand V, Schaller R, Jarman JWE, Harada M, Wei Y, Kusano K, Schmidt C, Hurtado MAA, Naksuk N, Hoshiyama T, Kancharla K, Iida Y, Mizobuchi M, Morin DP, Cay S, Paglino G, Dahme T, Agarwal S, Vijayaraman P, Sharma PS

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   66 巻 ( 7 ) 頁: 1589 - 1600   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10840-022-01417-4

    PubMed

  13. Subclinical persistent atrial fibrillation in left atrium behind the ectopic atrial rhythm on electrocardiogram.

    Mizutani Y, Yanagisawa S, Makino Y, Kanashiro M, Inden Y, Murohara T

    HeartRhythm case reports   9 巻 ( 9 ) 頁: 685 - 688   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.hrcr.2023.07.005

    PubMed

  14. Different time course effect of autonomic nervous modulation after cryoballoon and hotballoon catheter ablations for paroxysmal atrial fibrillation.

    Suzuki N, Inden Y, Yanagisawa S, Shimizu Y, Narita S, Hiramatsu K, Yamauchi R, Watanabe R, Tsurumi N, Shimojo M, Suga K, Tsuji Y, Shibata R, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing     2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10840-023-01581-1

    PubMed

  15. Transmural lesion formation after left atrial roof cryoballoon ablation: Insight from simultaneous high-density epicardial mapping.

    Kato H, Yanagisawa S, Sakurai T, Murakami H, Inden Y, Murohara T

    Heart rhythm O2   4 巻 ( 5 ) 頁: 329 - 332   2023年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.hroo.2023.02.004

    PubMed

  16. Successful catheter ablation for a dominant atrial fibrillation driver manifested after box isolation using a novel mapping system in a patient with persistent atrial fibrillation.

    Tachi M, Teraoka T, Hayashi K, Yanagisawa S, Inden Y, Murohara T

    HeartRhythm case reports   9 巻 ( 5 ) 頁: 319 - 323   2023年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.hrcr.2023.02.010

    PubMed

  17. Catheter ablation for atrial fibrillation in heart failure: Getting closer to the full picture in the whole population.

    Yanagisawa S, Inden Y, Murohara T

    International journal of cardiology   376 巻   頁: 81 - 82   2023年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ijcard.2023.02.010

    PubMed

  18. A rare case of delayed complete lead dislodgement after deep septal pacing: A hidden risk of the specific procedure.

    Watanabe R, Inden Y, Yanagisawa S, Narita Y, Hiramatsu K, Yamauchi R, Tsurumi N, Suzuki N, Shimojo M, Suga K, Tsuji Y, Murohara T

    Pacing and clinical electrophysiology : PACE   46 巻 ( 4 ) 頁: 341 - 345   2023年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/pace.14688

    PubMed

  19. A novel practical algorithm using machine learning to differentiate outflow tract ventricular arrhythmia origins.

    Shimojo M, Inden Y, Yanagisawa S, Suzuki N, Tsurumi N, Watanabe R, Nakagomi T, Okajima T, Suga K, Tsuji Y, Murohara T

    Journal of cardiovascular electrophysiology   34 巻 ( 3 ) 頁: 627 - 637   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jce.15823

    PubMed

  20. A case of successful catheter ablation of blocked atrial bigeminy and bradycardia with the recovery of normal sinus rhythm and myocardial reverse remodeling.

    Sugiyama T, Mizutani Y, Yanagisawa S, Kanashiro M, Inden Y, Murohara T

    Clinical case reports   10 巻 ( 12 ) 頁: e6791   2022年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ccr3.6791

    PubMed

  21. Evaluation of the direction and extent of ice formation during cryoballoon ablation: an experimental study.

    Mizutani Y, Yanagisawa S, Fujiwara G, Kasai Y, Tajima A, Makino Y, Suzuki H, Hiramatsu T, Ichimiya H, Uchida Y, Watanabe J, Kanashiro M, Inden Y, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing     2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Interventional Cardiac Electrophysiology  

    Background: The distal hemisphere of a balloon is generally cooled during cryoapplication. However, a wide ablation area can be acquired after cryoballoon ablation. This study aimed to evaluate the extent of ice formation on two types of balloon surfaces through experimental and simulation studies. Methods: A standard cryoballoon (SCB; Arctic Front Advance Pro, Medtronic) and novel cryoballoon (NCB; POLARx, Boston Scientific) were frozen for 240 s in 36 °C normal saline solution to observe ice formation on the balloon surface. Pieces of porcine tissue were placed between the upper and lower sides of the balloon, and the balloon was frozen in the horizontal direction for 240 s in 20 attempts (10 for SCB and NCB each). The measured areas of ice formation were evaluated and compared between the upper and lower sides of each balloon. Results: Ice formation was greater on the lower side of the balloon than on the upper side. A larger area of ice formation in the tissue slab was observed on the lower side than on the upper side in both balloons, and the ice formation extended to the proximal hemisphere on the lower side of the balloon. The ice formation area in the NCB was significantly larger than that in SCB. Conclusions: Ice formation was significantly greater on the lower side of the cryoballoon than on the upper side and extended to the proximal hemisphere of the balloon, which might facilitate the acquisition of a wide ablation area on the left atrial posterior wall after cryoballoon ablation. Graphical Abstract: Different ice formation after cryoballoon ablation Greater ice formation on the lower side of cryoballoon and an extensive ice formation in the proximal hemisphere, especially in novel cryoballoon. [Figure not available: see fulltext.]

    DOI: 10.1007/s10840-022-01411-w

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    Scopus

    PubMed

  22. Regional left atrial conduction velocity in the anterior wall is associated with clinical recurrence of atrial fibrillation after catheter ablation: efficacy in combination with the ipsilateral low voltage area.

    Ohguchi S, Inden Y, Yanagisawa S, Fujita R, Yasuda K, Katagiri K, Oguri M, Murohara T

    BMC cardiovascular disorders   22 巻 ( 1 ) 頁: 457   2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC Cardiovascular Disorders  

    Background: Left atrial (LA) conduction velocity (CV) is an electrical remodeling parameter of atrial fibrillation (AF) substrate. However, the pathophysiological substrate of LA-CV and its impact on outcomes after catheter ablation for AF have not been well evaluated. Methods: We retrospectively evaluated 119 patients with AF who underwent catheter ablation and electroanatomical mapping during sinus rhythm. To measure regional LA-CV, we took triplet sites (A, B, and C) on the activation map and calculated the magnitude of the matched orthogonal projection vector between vector-AB and vector-AC, indicating two-dimensional CV. The median of the LA-CVs from four triad sites in both the anterior and posterior walls was set as the ‘model LA-CV’. We evaluated the impact of the model LA-CV on recurrence after ablation and relationship between the model LA-CV and LA-low voltage area (LVA) of < 0.5 mV. Results: During the 12-month follow-up, 29 patients experienced recurrence. The LA-CV model was significantly correlated with ipsilateral LVA. The lower anterior model LA-CV was significantly associated with recurrence, with the cut-off value of 0.80 m/s having a sensitivity of 72% and specificity of 67%. Multivariable analysis revealed that the anterior model LA-CV (hazard ratio, 0.09; 95% confidence interval, 0.01–0.94; p = 0.043) and anterior LA-LVA (hazard ratio, 1.06; 95% confidence interval, 1.00–1.11; p = 0.033) were independently associated with AF recurrence. The anterior LA-LVA was mildly correlated with the anterior model LA-CV (r = -0.358; p < 0.001), and patients with both lower LA-CV and greater anterior LA-LVA based on each cut-off value had the worst prognosis. However, decreased LA-CV was more likely to be affected by the distribution pattern of the LVA rather than the total size of the LVA. Conclusion: Decreased anterior LA-CV was a significant predictor of AF recurrence and was a useful electrical parameter in addition to LA-LVA for estimating AF arrhythmogenicity.

    DOI: 10.1186/s12872-022-02881-6

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  23. Impact of synchronized left ventricular pacing rate on risk for ventricular tachyarrhythmias after cardiac resynchronization therapy in patients with heart failure.

    Okajima T, Inden Y, Yanagisawa S, Suga K, Shimojo M, Nakagomi T, Tsurumi N, Watanabe R, Suzuki N, Shibata R, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   65 巻 ( 1 ) 頁: 239 - 249   2022年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Interventional Cardiac Electrophysiology  

    Background: The adaptive cardiac resynchronization therapy (aCRT) algorithm automatically produces synchronized left ventricular pacing (sLVP) with intrinsic atrioventricular conduction to improve clinical outcomes. However, relationship between sLVP percentage and risk for ventricular tachyarrhythmia (VT/VF) remains unclear. This study aimed to evaluate the clinical impact of sLVP rate on VT/VF occurrence. Methods: In total, 1,419 device interrogation data from 42 consecutive patients who underwent new aCRT device implantation were retrospectively analyzed. The primary endpoint was the first time VT/VF episode after aCRT device implantation. Results: During a median follow-up of 34 months, 15 patients had VT/VF episodes. Patients were divided into a high sLVP (the average sLVP percentage of ≥ 51.5%, n = 27) or low sLVP group (< 51.5%, n = 15). The high sLVP group had a significantly lower VT/VF incidence (22% vs. 60%; p = 0.014) and an independent predictor for VT/VF occurrence on multivariate analysis (hazard ratio 0.21; p = 0.007). LV ejection fraction improvements after 6 months (12.3 ± 8.7% vs. 2.8 ± 10.3%; p = 0.004) and 12 months (13.8 ± 9.3% vs. 6.2 ± 11.1%; p = 0.030) were significantly greater in the high sLVP group than in the low sLVP group. Age, PR interval, and left atrial diameter were significantly associated with the sLVP rate after aCRT. Conclusions: Patients with high sLVP percentage after aCRT had lower long-term risk of VT/VF incidence with a favorable response to CRT. A synchronized pacing algorithm using intrinsic conduction may prevent malignant arrhythmias, as well as recover cardiac functions.

    DOI: 10.1007/s10840-022-01284-z

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  24. Efficacy and feasibility of cryoballoon ablation for atrial fibrillation in patients with heart failure: A large-scale multicenter study.

    Yanagisawa S, Suzuki H, Kanzaki Y, Ishikawa S, Kamikubo Y, Okumura S, Kato H, Mizutani Y, Murase Y, Nakasuka K, Warita S, Sekimoto S, Takemoto Y, Takasugi N, Ohguchi S, Senga M, Yokoi K, Shibata R, Inden Y, Murohara T

    Journal of cardiovascular electrophysiology     2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Cardiovascular Electrophysiology  

    Introduction: Data are limited regarding outcomes of cryoballoon ablation for atrial fibrillation (AF) in patients with heart failure (HF). This large-scale multicenter study aimed to evaluate the prognosis of patients with HF after cryoballoon ablation for AF. Methods: Among 3655 patients undergoing cryoballoon ablation at 17 institutions, 549 patients (15%) (391 with paroxysmal AF and 158 with persistent AF) diagnosed with HF preoperatively were analyzed. Clinical endpoints were recurrence, mortality, and HF hospitalization after ablation. Results: Most patients had a preserved left ventricular ejection fraction (LVEF) ≥ 50%. During a mean follow-up period of 25.7 months, recurrence, all-cause death, and HF hospitalization occurred in 29%, 4.0%, and 4.8%, respectively. Cardiac function on echocardiography and B-type natriuretic peptide (BNP) levels significantly improved postoperatively, and the effect was more pronounced in the nonrecurrence group. Major complications occurred in 33 patients (6.0%), but most complications were phrenic nerve palsy (3.6%). Although death and HF hospitalization occurred more frequently in patients with LVEF ≤ 40% (n = 73) and New York Heart Association (NYHA) class III–IV (n = 19) than other subgroups, the BNP levels, and LVEF significantly improved after ablation in all LVEF and NYHA class subgroups. High BNP levels, NHYA class, CHADS2 score, and structural heart disease, but not postablation recurrence, independently predicted death, and HF hospitalization on multivariate analysis. The patients with tachycardia-induced cardiomyopathy had better recovery of BNP levels and LVEF after ablation than those with structural heart disease. Conclusions: Cryoballoon ablation for AF in HF patients is feasible and leads to significantly improved cardiac function.

    DOI: 10.1111/jce.15691

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  25. Depolarization and repolarization dynamics after His-bundle pacing: Comparison with right ventricular pacing and native ventricular conduction.

    Yanagisawa S, Inden Y, Watanabe R, Tsurumi N, Suzuki N, Nakagomi T, Shimojo M, Okajima T, Riku S, Furui K, Suga K, Shibata R, Murohara T

    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc   27 巻 ( 5 ) 頁: e12991   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Annals of Noninvasive Electrocardiology  

    Background: The current study aimed to evaluate changes in electrical depolarization and repolarization parameters after His-bundle pacing (HBP) compared with right ventricular pacing (RVP) and its association with ventricular arrhythmia (VA). Methods: Forty-one patients (13 with HBP, 14 with RVP, and 14 controls [AAI mode]) were evaluated. After continuous pacing algorithm, QRS duration, QT interval, QTc, JT interval, T-peak to T-end (Tpe), and Tpe/QT ratio were measured on electrocardiography at baseline and 1 week, 1 month, and 6 months postoperatively. We investigated VA occurrence and adverse events after implantation. Results: At 6 months, QRS duration was significantly shorter in the HBP (121.6 ± 15.6 ms) than in the RVP (150.1 ± 14.9 ms) group. The QT intervals were lower in the HBP (424.0 ± 40.9 ms) and control (405.9 ± 23.0 ms) groups than in the RVP (453.0 ± 40.2 ms) group. The Tpe and Tpe/QT ratios at 6 months differed significantly between the HBP and RVP groups (Tpe, 69.8 ± 19.7 ms vs 87.4 ± 11.9 ms and Tpe/QT, 0.16 ± 0.03 vs 0.19 ± 0.02, respectively). The Tpe and Tpe/QT ratios were similarly shortened in the HBP and control groups. VA occurred less frequently in the HBP (15%) and control (7.1%) groups than in the RVP (50%) group (p = 0.020). The non-RVP group showed significantly lower rates of VA and major adverse events than the RVP group. Patients with VA demonstrated significantly longer QRS duration, QT interval, Tpe, and Tpe/QT at 6 months than those without VA. Conclusion: HBP showed better depolarization and repolarization stability than RVP.

    DOI: 10.1111/anec.12991

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  26. Characteristics of successful reactive atrial-based antitachycardia pacing in patients with cardiac implantable electronic devices: History of catheter ablation of atrial fibrillation as a predictor of high treatment efficacy.

    Nakagomi T, Inden Y, Yanagisawa S, Suzuki N, Tsurumi N, Watanabe R, Shimojo M, Okajima T, Suga K, Shibata R, Murohara T

    Journal of cardiovascular electrophysiology   33 巻 ( 7 ) 頁: 1515 - 1528   2022年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Cardiovascular Electrophysiology  

    Introduction: Reactive atrial-based antitachycardia pacing (rATP) in patients with cardiac implantable electronic devices (CIEDs) suppresses the progression of atrial fibrillation (AF) to the persistent form. However, the clinical factors associated with successful reactive atrial-based antitachycardia pacing (rATP) treatment are unknown. This study aimed to examine the predictors of high rATP efficacy in patients with CIEDs. Methods: The data of 101,325 rATP-treated atrial tachyarrhythmia (AT/AF) episodes in 51 patients, obtained through remote monitoring and device interrogation, were analyzed. The study population was divided into the high and low efficacy groups based on the overall median success rate of rATP. Clinical characteristics were compared between the two groups. Results: During a follow-up period of 28.6 ± 8.6 months, the median success rate was 43.7% (31.5%–64.9%). The prevalence of a history of catheter ablation of AF was significantly higher in the high efficacy group than in the low efficacy group (73.0% vs. 44.0%, p =.048) and was the only independent predictor of high rATP efficacy (odds ratio, 3.45; p =.038). The rATP success rate in patients with (n = 30) and without (n = 21) a history of catheter ablation was 53.9% (40.0%–67.5%) and 36.4% (22.2%–47.7%), respectively (p =.012). The effect of rATP after ablation was more pronounced in patients with long cycle length episodes (≥75% of AT/AF sequences having a cycle length of 200–449 ms) (67.3% [46.0%–73.6%] vs. 30.6% [18.1%–60.3%], p =.027). The high efficacy group had a significantly lower incidence of AT/AF lasting ≥1, ≥7, and ≥30 days than the low efficacy group. Conclusion: rATP combined with catheter ablation therapy is effective in suppressing AT/AF.

    DOI: 10.1111/jce.15551

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  27. Coagulation Response and Prothrombotic Effect of Uninterrupted Oral Anticoagulant Administration After Catheter Ablation for VT.

    Yanagisawa S, Inden Y, Riku S, Furui K, Suga K, Nakagomi T, Shimojo M, Okajima T, Watanabe R, Tsurumi N, Suzuki N, Shibata R, Murohara T

    JACC. Clinical electrophysiology   8 巻 ( 6 ) 頁: 735 - 748   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JACC: Clinical Electrophysiology  

    Background: Catheter ablation for ventricular tachycardia (VT) is associated with perioperative thromboembolic risk. However, the strategy for postprocedural management remains unknown. Objectives: The aim of this study was to evaluate the prothrombotic response after VT ablation in various coagulation biomarkers in patients with and without the administration of oral anticoagulation (OAC). Methods: Data from 112 patients (58 with uninterrupted OAC and 54 without) with structural heart disease who underwent endocardial VT ablation were retrospectively analyzed. We also included 41 patients who underwent ablation for premature ventricular contraction from the right ventricle and 13 patients who underwent electrophysiology study (the control group). Blood samples of coagulation markers were collected before and 3 days after the procedure in all patients. Results: The percentage of D-dimer levels ≤1.0 μg/mL at baseline was lower in the VT ablation groups (76% and 50% in the OAC and non-OAC groups, respectively) than in the other groups (100%). After 3 days, the percentage remained at 67% in the OAC group; however, the non-OAC VT group demonstrated a remarkable decrease of 20%. Similarly, fibrin monomer complex, thrombin antithrombin, and prothrombin fragment 1+2 levels were well suppressed in the control, premature ventricular contraction, and OAC groups. However, the non-OAC group demonstrated increased coagulation markers both before and after 3 days. Multivariate analysis demonstrated that OAC administration and normal coagulation markers at baseline were independent predictors of stable coagulation status after ablation. Conclusions: The coagulation cascade was significantly activated in patients undergoing VT ablation. Uninterrupted OAC administration suppressed the coagulation response, which might be associated with a reduction in perioperative prothrombotic risk.

    DOI: 10.1016/j.jacep.2022.02.015

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  28. Comparison of the empirical linear ablation and low voltage area-guided ablation in addition to pulmonary vein isolation in patients with persistent atrial fibrillation: a propensity score-matched analysis.

    Suzuki N, Kaneko S, Fujita M, Shinoda M, Kubota R, Ohashi T, Tatami Y, Suzuki J, Hori H, Adachi K, Ito R, Shirai Y, Yanagisawa S, Inden Y, Murohara T

    BMC cardiovascular disorders   22 巻 ( 1 ) 頁: 13   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC Cardiovascular Disorders  

    Background: The efficacy of pulmonary vein isolation (PVI) alone is not guaranteed for persistent atrial fibrillation (PeAF), and it is unclear which type of ablation approach should be applied in addition to PVI. This study aimed to compare outcomes and prognosis between empirical linear ablation and low-voltage area (LVA) ablation after PVI for PeAF. Methods: We enrolled 128 patients with PeAF who were assigned to the linear ablation group (n = 64) and the LVA ablation group (n = 64) using a propensity score-matched model. After PVI and cardioversion, the patients underwent either empirical linear ablation or LVA ablation during sinus rhythm. All patients in the linear ablation group underwent both roof line and mitral valve isthmus (MVI) ablations. An electrical-guided ablation targeting LVA (< 0.5 mV) was performed in the LVA group. When there was no LVA in the LVA group, only PVI was applied. We compared the procedural outcomes and recurrence after ablation between the two groups. Results: The baseline characteristics were well-balanced between the two groups. Fifty patients had LVA (22 and 28 patients in the linear and LVA groups). The roof and MVI lines were completed in 100% and 96.9% of the patients. During the mean follow-up of 279.5 ± 161.3 days, the LVA group had significantly lower recurrence than the linear group (15 patients [23%] vs. 29 patients [45%], p = 0.014). Thirty-five patients were prescribed antiarrhythmic drugs during the follow-up period (linear group, n = 17; LVA group, n = 18); amiodarone and bepridil were administered to most of the patients (15 and 17 patients, respectively). The difference in the prognosis was relevant among the patients with LVA, while this trend was not observed in those without LVA. The LVA ablation group demonstrated significantly lower radiofrequency energy and shorter procedural time compared to the linear ablation group. The recurrence of atrial flutter was more likely to occur in the linear group than in the LVA group (14 [22%] vs. 6 [9.4%], p = 0.052). Conclusion: The electrophysiological-guided LVA ablation is more effective than empirical linear ablation in PeAF patients with LVA. Unnecessary empirical linear ablation might have a risk of iatrogenic gap and atrial flutter recurrence.

    DOI: 10.1186/s12872-022-02460-9

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  29. Efficacy of His Bundle Pacing on LV Relaxation and Clinical Improvement in HF and LBBB.

    Kato H, Yanagisawa S, Sakurai T, Mizuno C, Ota R, Watanabe R, Suga K, Okada T, Murakami H, Kada K, Inden Y, Tsuboi N, Murohara T

    JACC. Clinical electrophysiology   8 巻 ( 1 ) 頁: 59 - 69   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JACC: Clinical Electrophysiology  

    Objectives: This study aimed to compare acute hemodynamic improvements and responses to His bundle pacing (HBP) and conventional biventricular pacing (BVP). Background: HBP can correct left bundle branch block (LBBB) and may be an alternative cardiac resynchronization therapy (CRT) to BVP. Methods: Fourteen consecutive patients with heart failure (HF) and typical LBBB who required CRT were enrolled. The acute hemodynamic responses during HBP and BVP were compared using a micromanometer-tipped catheter inserted into the left ventricle (LV) before CRT. Each configuration was compared with AAI mode. A permanent HBP device was implanted when LBBB correction threshold was ≤1.5 V at 1.0 ms, and remaining patients were treated with BVP. Clinical and echocardiographic improvements were assessed during a 12-month follow-up period. Results: The LV contractile index (positive maximal rate of LV pressure rise [dP/dtmax]) increased similarly during HBP and BVP (18.8% ± 6.4% vs 18.0% ± 10.2%; P = 0.810). LV relaxation indices (negative dP/dtmax and tau) were significantly improved during HBP compared with BVP (negative dP/dtmax: 14.3% ± 5.5% vs 3.1% ± 8.1%; P < 0.001; tau: 7.2% ± 4.3% vs −0.8% ± 8.1%; P = 0.001). Nine (64%) patients received permanent HBP devices, while 5 patients were treated with BVP. The New York Heart Association functional class, LV ejection fraction, LV end-systolic volume, and B-type natriuretic peptide level improved in patients treated with HBP and BVP (all P < 0.05 vs baseline). Patients treated with HBP exhibited earlier and greater improvements of the LV ejection fraction and LV end-systolic volume than did those with BVP. Conclusions: HBP improves systolic function and LV relaxation in patients with HF and LBBB. CRT via HBP produced earlier and greater clinical responses than BVP.

    DOI: 10.1016/j.jacep.2021.06.011

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  30. Usefulness of the Snare Technique During Leadless Pacemaker Implantation for a Patient with a Severely Dilated Right Atrium.

    Hiramatsu T, Mizutani Y, Yanagisawa S, Sugiyama T, Yamashita D, Tajima A, Yonekawa J, Makino Y, Suzuki H, Ichimiya H, Uchida Y, Watanabe J, Kanashiro M, Inden Y, Murohara T

    International heart journal   63 巻 ( 1 ) 頁: 159 - 162   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Heart Journal  

    We report here the case of a 92-year-old woman with atrial fibrillation bradycardia in which leadless pacemaker implantation was performed with a difficult delivery of the catheter sheath due to an extremely large right atrium. Using a snare technique with correction of the direction of the force on the catheter toward the right ventricle (RV) can result in successful delivery of the pacemaker catheter and stable placement of the pacemaker system in the RV septum. This specific snare technique has the potential to facilitate leadless pacemaker implantation safely in a severely dilated chamber of the heart, making this technique effective to use in clinical practice.

    DOI: 10.1536/ihj.21-499

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  31. Evaluation of the Novel Automated Anti-Tachycardia Pacing Algorithm Successfully Terminating Sustained Monomorphic Ventricular Tachycardia in an Electrophysiology Study.

    Yanagisawa S, Inden Y, Okajima T, Nakagomi T, Shimojo M, Watanabe R, Tsurumi N, Suzuki N, Suga K, Shibata R, Murohara T

    International heart journal   63 巻 ( 3 ) 頁: 633 - 638   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Heart Journal  

    We report the usefulness of novel automated anti-tachycardia pacing (ATP) for ventricular tachycardia (VT) termination evaluated in an electrophysiology study. This intrinsic, automated ATP with an implanted cardiac resynchronization therapy-defibrillator successfully terminated the sustained VT, which had not been suppressed by repetitive burst pacing from the electrode catheter. The reproduction of programed pacing of the automated ATP by a right ventricular electrode catheter was effective in terminating VT, and this termination was absolute and reproducible. Further detailed assessment in an electrophysiology study could highlight the algorithm of the automated ATP and its possible benefit in terminating the reentrant VT.

    DOI: 10.1536/ihj.21-755

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  32. Identification of high priority focal activations in persistent atrial fibrillation using a novel mapping strategy.

    Shimojo M, Inden Y, Yanagisawa S, Riku S, Suga K, Furui K, Nakagomi T, Okajima T, Shibata R, Murohara T

    Heart and vessels     2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00380-021-01977-x

    PubMed

  33. Short coupling interval with high burden of atrial ectopy predicts recurrence after atrial fibrillation ablation.

    Okajima T, Inden Y, Yanagisawa S, Imai H, Murase Y, Ogawa Y, Kawaguchi K, Murohara T

    Heart and vessels     2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00380-021-01966-0

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  34. Cryoballoon ablation for atrial fibrillation without the use of a contrast medium: a combination of the intracardiac echocardiography and pressure wave monitoring guided approach.

    Makino Y, Mizutani Y, Yamashita D, Yonekawa J, Satake A, Kurobe M, Hiramatsu T, Ichimiya H, Uchida Y, Watanabe J, Kanashiro M, Ichimiya S, Yanagisawa S, Inden Y, Murohara T

    Heart and vessels     2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00380-021-01963-3

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  35. Earliest pulmonary vein potential-guided cryoballoon ablation is associated with better clinical outcomes than conventional cryoballoon ablation: A result from two randomized clinical studies.

    Mizutani Y, Yanagisawa S, Kanashiro M, Yamashita D, Yonekawa J, Makino Y, Hiramatsu T, Ichimiya H, Uchida Y, Watanabe J, Ichimiya S, Inden Y, Murohara T

    Journal of cardiovascular electrophysiology     2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jce.15246

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  36. Incidence of Left Atrial Thrombus Development and Imaging Approach in Patients Scheduled for Repeat Catheter Ablation for Atrial Fibrillation.

    Yanagisawa S, Inden Y, Riku S, Suga K, Furui K, Nakagomi T, Shimojo M, Okajima T, Shibata R, Murohara T

    The American journal of cardiology   155 巻   頁: 52 - 63   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:American Journal of Cardiology  

    The risk for developing left atrial (LA) thrombi after initial catheter ablation for atrial fibrillation (AF) and requirements for imaging evaluation for thrombi screening at repeat ablation is unclear. This study aimed to assess the occurrence of thrombus development and frequency of any imaging study evaluating thrombus formation during repeat ablation for AF. Of 2,066 patients undergoing initial catheter ablation for AF with uninterrupted oral anticoagulation, 615 patients underwent repeat ablation after 258.0 (105.0–882.0) days. We investigated the factors associated with safety outcomes and requirements for thrombus screening. All patients underwent at least one imaging examination to screen for thrombi in the initial session; however, the examination rate decreased to 476 patients (77%) before the repeat session. The frequency of imaging evaluations was 5.0%, 11%, 21%, 84%, and 91% for transesophageal echocardiography and 18%, 33%, 49%, 98%, and 99% for any imaging modality at repeat ablation performed ≤60 days, ≤90 days, ≤180 days, >180 days, and >1 year after the initial session, respectively. Three patients (0.5%) developed LA thrombi at repeat ablation due to identifiable causes, and no patients experienced thromboembolic events when no imaging evaluation was performed. Multivariate analysis revealed that repeat ablation performed after >180 days, non-paroxysmal atrial arrhythmias, and lower left ventricular ejection fraction were predictors of thrombus development and severe spontaneous echocardiography contrast. In conclusion, the risk for thrombus development at repeat ablation for AF was low. There needs to be a risk stratification of the imaging screening for thrombi at repeat ablation.

    DOI: 10.1016/j.amjcard.2021.06.019

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  37. Permanent His-bundle pacing using distal His-bundle electrogram-guided approach in patients with atrioventricular block.

    Suga K, Kato H, Inden Y, Yanagisawa S, Murakami H, Kada K, Tsuboi N, Murohara T

    Pacing and clinical electrophysiology : PACE     2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/pace.14363

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  38. Long P-wave duration immediately after pulmonary vein isolation on radiofrequency catheter ablation for atrial fibrillation predicts clinical recurrence: correlation with atrial remodeling in persistent atrial fibrillation.

    Ohguchi S, Inden Y, Yanagisawa S, Shigematsu T, Yasuda K, Katagiri K, Oguri M, Murohara T

    Heart and vessels     2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Heart and Vessels  

    © 2021, Springer Japan KK, part of Springer Nature. P-wave morphology reflects atrial remodeling and indicates prognosis after radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). The impact of p-wave morphology after excluding the effect of pulmonary vein (PV) substrate on outcomes is unknown. We evaluated the p-wave morphology on electrocardiography immediately after PV isolation for clinical outcomes. Eighty-four consecutive patients (47 with paroxysmal AF and 37 with persistent AF) who underwent RFCA were included. P-wave duration (PWD) and amplitude in all leads were examined during sinus rhythm immediately after PV isolation. We evaluated the relationship between electrocardiogram parameters and AF recurrence, according to the type of AF and following ablation, and the correlation with left atrial (LA) volume, low voltage ratio, and fixed conduction time. During 12 months of follow-up, 20 patients experienced recurrence. The cut-off value of PWD > 120 ms in lead I showed a sensitivity of 75% and specificity of 69% for predicting recurrence. PWD was significantly correlated with LA volume, low voltage, and conduction velocity. Significantly higher recurrence rates were observed in patients with PWD > 120 ms than in those with PWD ≤ 120 ms (p < 0.001), and the difference was more pronounced in patients with persistent AF. Multivariate analysis demonstrated that PWD > 120 ms was independently associated with recurrence in the total population (hazard ratio 2.00; 95% confidence interval 1.27–3.22; p = 0.003) and in patients with persistent AF. In conclusion, long PWD after PV isolation predicts AF recurrence, which might be associated with the extent of the LA substrate in persistent AF.

    DOI: 10.1007/s00380-021-01932-w

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  39. Impact of Preoperative Nutritional Status on the Outcome of Catheter Ablation for Atrial Fibrillation.

    Furui K, Morishima I, Morita Y, Kanzaki Y, Takagi K, Nagai H, Watanabe N, Yoshioka N, Yamauchi R, Miyazawa H, Yanagisawa S, Inden Y, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society     2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1253/circj.CJ-21-0218

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  40. Dynamic Changes in Electrocardiogram Parameters After Epicardial Substrate Catheter Ablation of Brugada Syndrome.

    Mamiya K, Inden Y, Yanagisawa S, Fujii A, Tomomatsu T, Okamoto H, Riku S, Suga K, Furui K, Nakagomi T, Shibata R, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society   85 巻 ( 8 ) 頁: 1283 - 1293   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Circulation Journal  

    Background: Catheter ablation (CA) is effective for recurrent episodes of ventricular fibrillation (VF) in Brugada syndrome (BrS). VF development in BrS is associated with several electrocardiogram (ECG) abnormalities. This study investigated changes in ECG parameters in high-risk BrS patients who underwent epicardial CA. Methods and Results: In all, 27 BrS patients were implanted with an implantable cardioverter-defibrillator (ICD). Patients were divided into 2 groups: (1) an ablation group (n=11) that underwent epicardial CA because of VF recurrence; and (2) a primary prevention (PP) group (n=16) with ICD implantation only. ECG parameters were evaluated before and 12 months after CA and compared with ECG parameters in the PP group. The T wave peak-to-end interval was significantly longer and the number of abnormal spikes in leads V1-V3 at the second, third, and fourth intercostal spaces was greater in the ablation than PP group. After ablation, ST levels and the sum of abnormal spikes in leads V1-V3 were significantly decreased. The mean (±SD) number of ICD shocks decreased markedly during a mean follow-up period of 42.0 months (from 3.8±3.7 to 0.2±0.4/year). Four patients had an ICD shock following the ablation procedure. Greater reductions in ST-segment elevation and abnormal spikes were observed in the group without than with VF recurrence. Conclusions: Improvements in surface ECG parameters appear to be associated with successful ablation in high-risk BrS patients.

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  41. Comparison of medically versus surgically treated acute type a aortic dissection in patients &lt;80 years old versus patients ≥80 years old.

    Yanagisawa S, Yuasa T, Suzuki N, Hirai T, Yasuda N, Miki K, Yasuura K, Horiuchi K, Tanaka T

    The American journal of cardiology   108 巻 ( 3 ) 頁: 453 - 9   2011年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.amjcard.2011.03.067

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  42. Early improvement of daily physical activity after catheter ablation for atrial fibrillation in an accelerometer assessment: A prospective pilot study

    Yanagisawa S.

    Annals of Noninvasive Electrocardiology   26 巻 ( 1 )   2021年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Annals of Noninvasive Electrocardiology  

    DOI: 10.1111/anec.12807

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  43. A case of heart failure complicated with double ventricular response triggered by beta blocker

    Kazama S.

    HeartRhythm Case Reports     2021年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:HeartRhythm Case Reports  

    DOI: 10.1016/j.hrcr.2020.12.004

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  44. The mechanism and prognosis of acute and late improvement in mitral regurgitation after cardiac resynchronization therapy

    Okamoto H.

    Heart and Vessels     2021年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Heart and Vessels  

    DOI: 10.1007/s00380-021-01771-9

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  45. Disappearance pattern and the last remaining earliest pulmonary vein potential during cryoballoon ablation in predicting recurrence and conduction gap site of pulmonary veins

    Mizutani Y.

    Heart and Vessels     2021年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Heart and Vessels  

    DOI: 10.1007/s00380-021-01785-3

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  46. Safety and efficacy of first-line cryoablation for para-hisian ventricular arrhythmias using a cryomapping protocol approach: A case series

    Mizutani Y.

    Clinical Case Reports   8 巻 ( 12 ) 頁: 3248 - 3253   2020年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical Case Reports  

    DOI: 10.1002/ccr3.3401

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  47. Autopsy evaluation of the implantation site of a His bundle pacing lead demonstrating selective capture

    Kato H.

    PACE - Pacing and Clinical Electrophysiology   43 巻 ( 11 ) 頁: 1412 - 1416   2020年11月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:PACE - Pacing and Clinical Electrophysiology  

    DOI: 10.1111/pace.13989

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  48. The impact of the dominant frequency of body surface electrocardiography in patients with persistent atrial fibrillation

    Murase Y.

    Heart and Vessels   35 巻 ( 7 ) 頁: 967 - 976   2020年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Heart and Vessels  

    DOI: 10.1007/s00380-020-01563-7

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  49. Electrocardiogram characteristics of P wave associated with successful pulmonary vein isolation in patients with paroxysmal atrial fibrillation: Significance of changes in P-wave duration and notched P wave

    Yanagisawa Satoshi, Inden Yasuya, Okamoto Hiroya, Fujii Aya, Sakamoto Yusuke, Mamiya Keita, Tomomatsu Toshiro, Shibata Rei, Murohara Toyoaki

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   25 巻 ( 2 ) 頁: e12712   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/anec.12712

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  50. Anatomical assessment of crosstalk phenomenon during laser balloon ablation with imaging in a patient with unusual atrial hypertrophy

    Yanagisawa Satoshi, Inden Yasuya, Okamoto Hiroya, Tomomatsu Toshiro, Fujii Aya, Mamiya Keita, Shibata Rei, Murohara Toyoaki

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   57 巻 ( 1 ) 頁: 157-159   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10840-019-00632-w

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  51. Study design and protocol for evaluating the long-term prognosis of patients receiving his bundle pacing: A multicenter observational study

    Yanagisawa S.

    Journal of Arrhythmia   35 巻 ( 5 ) 頁: 760 - 765   2019年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Arrhythmia  

    DOI: 10.1002/joa3.12229

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  52. Correction to: Differences in prothrombotic response between the uninterrupted and interrupted apixaban therapies in patients undergoing cryoballoon ablation for paroxysmal atrial fibrillation: a randomized controlled study (Heart and Vessels, (2019), 34, 9, (1533-1541), 10.1007/s00380-019-01370-9)

    Ando M.

    Heart and Vessels   34 巻 ( 9 )   2019年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Heart and Vessels  

    DOI: 10.1007/s00380-019-01424-y

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  53. Differences in prothrombotic response between the uninterrupted and interrupted apixaban therapies in patients undergoing cryoballoon ablation for paroxysmal atrial fibrillation: a randomized controlled study

    Ando M.

    Heart and Vessels   34 巻 ( 9 ) 頁: 1533 - 1541   2019年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Heart and Vessels  

    DOI: 10.1007/s00380-019-01370-9

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  54. Discontinuous contraction in the left ventricle assessed by 2-D speckle tracking echocardiography benefits from CRT

    Fujii A.

    PACE - Pacing and Clinical Electrophysiology   42 巻 ( 9 ) 頁: 1204 - 1212   2019年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:PACE - Pacing and Clinical Electrophysiology  

    DOI: 10.1111/pace.13759

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  55. T-wave changes of cardiac memory caused by frequent premature ventricular contractions originating from the right ventricular outflow tract

    Sakamoto Y.

    Journal of Cardiovascular Electrophysiology   30 巻 ( 9 ) 頁: 1549 - 1556   2019年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Cardiovascular Electrophysiology  

    DOI: 10.1111/jce.14008

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  56. Identification of precise accessory pathway using ultra-high-resolution three-dimensional mapping system: utility and feasibility in preliminary experience

    Yanagisawa S.

    Journal of Interventional Cardiac Electrophysiology   55 巻 ( 2 ) 頁: 241 - 242   2019年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Interventional Cardiac Electrophysiology  

    DOI: 10.1007/s10840-019-00582-3

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  57. His bundle pacing with unusual automaticity

    Yanagisawa Satoshi, Inden Yasuya, Shibata Rei, Murohara Toyoaki

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   30 巻 ( 6 ) 頁: 966-968   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jce.13904

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    Scopus

    PubMed

  58. Adjacentmultiple accessory pathways demonstrated on ultra-high-resolution mapping

    Yanagisawa Satoshi, Inden Yasuya, Murohara Toyoaki

    EUROPACE   21 巻 ( 5 ) 頁: 723-723   2019年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/europace/euz044

    Web of Science

    Scopus

    PubMed

  59. Uninterrupted Direct Oral Anticoagulant and Warfarin Administration in Elderly Patients Undergoing Catheter Ablation for Atrial Fibrillation: A Comparison With Younger Patients.

    Yanagisawa S, Inden Y, Fujii A, Ando M, Funabiki J, Murase Y, Takenaka M, Otake N, Ikai Y, Sakamoto Y, Shibata R, Murohara T

    JACC. Clinical electrophysiology   4 巻 ( 5 ) 頁: 592-600   2018年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jacep.2018.02.013

    PubMed

  60. Renal function and risk of stroke and bleeding in patients undergoing catheter ablation for atrial fibrillation: Comparison between uninterrupted direct oral anticoagulants and warfarin administration

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Ikai Yoshihiro, Sakamoto Yusuke, Shibata Rei, Murohara Toyoaki

    HEART RHYTHM   15 巻 ( 3 ) 頁: 348-354   2018年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.hrthm.2017.10.033

    Web of Science

    PubMed

  61. Assessment of autonomic nervous system modulation after novel catheter ablation techniques for atrial fibrillation using multiple short-term electrocardiogram recordings

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Kamikubo Yosuke, Kanzaki Yasunori, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Ikai Yoshihiro, Sakamoto Yusuke, Shibata Rei, Murohara Toyoaki

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   51 巻 ( 1 ) 頁: 35-44   2018年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10840-017-0295-x

    Web of Science

    PubMed

  62. Vagal response in cryoballoon ablation of atrial fibrillation and autonomic nervous system: Utility of epicardial adipose tissue location

    Yanagisawa Satoshi, Inden Yasuya, Mizutani Yoshiaki, Fujii Aya, Kamikubo Yosuke, Kanzaki Yasunori, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Hattori Tetsuyoshi, Shibata Rei, Murohara Toyoaki

    JOURNAL OF ARRHYTHMIA   33 巻 ( 4 ) 頁: 275-282   2017年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.joa.2017.03.001

    Web of Science

    PubMed

  63. Impaired renal function is associated with recurrence after cryoballoon catheter ablation for paroxysmal atrial fibrillation: A potential effect of non-pulmonary vein foci.

    Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Ando M, Hirai M, Shibata R, Murohara T.

    J Cardiol.   69 巻 ( 1 ) 頁: 3-10   2017年1月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  64. An ECG Index of P-Wave Force Predicts the Recurrence of Atrial Fibrillation after Pulmonary Vein Isolation

    Kanzaki Y.

    PACE - Pacing and Clinical Electrophysiology   39 巻 ( 11 ) 頁: 1191 - 1197   2016年11月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:PACE - Pacing and Clinical Electrophysiology  

    DOI: 10.1111/pace.12956

    Scopus

  65. Effect and Significance of Early Reablation for the Treatment of Early Recurrence of Atrial Fibrillation After Catheter Ablation. 査読有り

    Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Ando M, Hirai M, Shibata R, Murohara T.

    Am J Cardiol.   118 巻 ( 6 ) 頁: 833-841   2016年9月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  66. Decrease in B-Type Natriuretic Peptide Levels and Successful Catheter Ablation for Atrial Fibrillation in Patients with Heart Failure. 査読有り

    Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Hirai M, Murohara T.

    Pacing Clin Electrophysiol.   39 巻 ( 3 ) 頁: 225-234   2016年3月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/pace.12788

  67. Elevated Red Blood Cell Distribution Width Predicts Recurrence After Catheter Ablation for Atrial Fibrillation in Patients With Heart Failure - Comparison With Non-Heart Failure Patients. 査読有り

    Yanagisawa S, Inden Y, Kato H, Miyoshi A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Hirai M, Murohara T.

    Circ J.   80 巻 ( 3 ) 頁: 627-638   2016年2月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1253/circj.CJ-15-1152

  68. Differences in activated clotting time among uninterrupted anticoagulants during the periprocedural period of atrial fibrillation ablation

    Nagao T.

    Heart Rhythm   12 巻 ( 9 ) 頁: 1972 - 1978   2015年9月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Heart Rhythm  

    DOI: 10.1016/j.hrthm.2015.04.016

    Scopus

  69. Impact of cardiac resynchronization therapy-defibrillator implantation on the association between body mass index and prognosis in patients with heart failure. 査読有り

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Ishikawa S, Kato H, Okumura S, Miyoshi-Fujii A, Nagao T, Yamamoto T, Mizutani Y, Ito T, Hirai M, Murohara T.

    J Interv Card Electrophysiol.   43 巻 ( 3 ) 頁: 269-277   2015年9月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  70. Alogliptin, a dipeptidyl peptidase-4 inhibitor, regulates the atrial arrhythmogenic substrate in rabbits

    Yamamoto T.

    Heart Rhythm   12 巻 ( 6 ) 頁: 1362 - 1369   2015年6月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Heart Rhythm  

    DOI: 10.1016/j.hrthm.2015.03.010

    Scopus

  71. Efficacy and safety of Apixaban in the patients undergoing the ablation of atrial fibrillation

    Nagao T.

    PACE - Pacing and Clinical Electrophysiology   38 巻 ( 2 ) 頁: 155 - 163   2015年2月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:PACE - Pacing and Clinical Electrophysiology  

    DOI: 10.1111/pace.12553

    Scopus

  72. Body mass index is associated with prognosis in Japanese elderly patients with atrial fibrillation: an observational study from the outpatient clinic. 査読有り

    Yanagisawa S, Inden Y, Yoshida N, Kato H, Miyoshi-Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Hirai M, Murohara T.

    Heart Vessels     2015年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00380-015-0765-y

  73. Feasibility and safety of uninterrupted dabigatran therapy in patients undergoing ablation for atrial fibrillation

    Nagao T.

    Internal Medicine   54 巻 ( 10 ) 頁: 1167 - 1173   2015年

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Internal Medicine  

    DOI: 10.2169/internalmedicine.54.3520

    Scopus

  74. Clinical characteristics and predictors of super-response to cardiac resynchronization therapy: a combination of predictive factors. 査読有り

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Fujita M, Ohguchi S, Ishikawa S, Kato H, Okumura S, Miyoshi A, Nagao T, Yamamoto T, Hirai M, Murohara T.

    Pacing Clin Electrophysiol.   37 巻 ( 11 ) 頁: 1553-1564   2014年11月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  75. Clinical outcome of implantable cardioverter defibrillators with recalled and non-recalled leads in Japanese patients. Increased failure rate of the Sprint Fidelis lead. 査読有り

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Ichiyanagi H, Fujita M, Ohguchi S, Ishikawa S, Kato H, Okumura S, Miyoshi A, Nagao T, Yamamoto T, Hirai M, Murohara T.

    Circ J.   78 巻 ( 2 ) 頁: 353-359   2014年2月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  76. Comparison of medically versus surgically treated acute type a aortic dissection in patients <80 years old versus patients >=80 years old. 査読有り

    Yanagisawa S, Yuasa T, Suzuki N, Hirai T, Yasuda N, Miki K, Yasuura K, Horiuchi K, Tanaka T.

    Am J Cardiol.   108 巻 ( 3 ) 頁: 453-459   2011年8月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  77. The prognostic value of treadmill exercise testing in very elderly patients: Heart rate recovery as a predictor of mortality in octogenarians. 査読有り

    Yanagisawa S, Miki K, Yasuda N, Hirai T, Suzuki N, Tanaka T.

    Europace.   13 巻 ( 1 ) 頁: 114-120   2011年1月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  78. Clinical outcomes and prognostic factor for acute heart failure in nonagenarians: Impact of hypoalbuminemia on mortality. 査読有り

    Yanagisawa S, Miki K, Yasuda N, Hirai T, Suzuki N, Tanaka T.

    Int J Cardiol.   145 巻 ( 3 ) 頁: 574-576   2010年12月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  79. Poor tolerance of beta-blockers by elderly patients with heart failure. 査読有り

    Yanagisawa S, Suzuki N, Tanaka T.

    Clin Interv Aging.   5 巻   頁: 365-368   2010年11月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  80. Right ventricular outflow tract obstruction: metastatic thyroid carcinoma. 査読有り

    Yanagisawa S, Suzuki Y, Yuasa T, Tanaka T.

    J Am Coll Cardiol.   55 巻 ( 11 ) 頁: 1159   2010年3月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  81. Clinical diagnosis of Schistosoma japonicum infection complicating infective endocarditis and liver cirrhosis. 査読有り

    Yanagisawa S, Yuasa T, Tanaka T.

    Intern Med.   44 巻 ( 11 ) 頁: 1001-1005   2010年

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

▼全件表示

書籍等出版物 2

  1. 人体のメカニズムから学ぶ臨床工学 循環器治療学 頻脈性不整脈の発生機序

    柳澤 哲、室原豊明( 担当: 共著)

    メジカルビュー社  2017年 

     詳細を見る

    総ページ数:7   記述言語:日本語 著書種別:教科書・概説・概論

  2. BIO Clinica, TOPICS 心房細動カテーテルアブレーション治療の周術期抗凝固療法

    柳澤 哲( 担当: 共著)

    北隆館  2018年11月 

     詳細を見る

    記述言語:日本語 著書種別:学術書

MISC 3

  1. Septal coronary artery fistula after left bundle branch area pacing assessed by multi-imaging modalities and shunt volume quantification

    Kato H, Yanagisawa S, Ota R, Murakami H, Kada K, Tsuboi N, Inden Y, Murohara T  

    Pacing and clinical electrophysiology : PACE45 巻 ( 11 ) 頁: 1299 - 1302   2022年11月

     詳細を見る

    記述言語:英語   出版者・発行元:PACE - Pacing and Clinical Electrophysiology  

    Septal coronary artery fistula is a rare but concerning complication of left bundle branch area pacing (LBBAP). We report the case of an 82-year-old man who was indicated for cardiac resynchronization therapy and underwent LBBAP. The patient had no chest symptoms during or after implantation. Postoperative echocardiography demonstrated a new abnormal tunnel inside the interventricular septum (IVS) and shunt flow from the IVS toward the right ventricle. Coronary angiography confirmed a septal coronary artery fistula, which might have been formed by failed deep screw attempts. Since the shunt volume assessed by the Qp/Qs was small, the patient was treated conservatively.

    DOI: 10.1111/pace.14548

    Web of Science

    Scopus

    PubMed

  2. Myocardial viability as shown by left ventricular lead pacing threshold and improved dyssynchrony by QRS narrowing predicts the response to cardiac resynchronization therapy. 査読有り

    Takenaka M, Inden Y, Yanagisawa S, Fujii A, Ando M, Funabiki J, Murase Y, Otake N, Sakamoto Y, Shibata R, Murohara T  

    Journal of cardiovascular electrophysiology   2018年12月

     詳細を見る

    記述言語:英語  

    DOI: 10.1111/jce.13806

    PubMed

  3. Clinical significance of the timing of early recurrence of atrial arrhythmia after pulmonary vein isolation: a two-institution clinical study. 査読有り

    Murase Y, Inden Y, Imai H, Kyo S, Yanagisawa S, Fujii A, Sakamoto Y, Tomomatsu T, Murohara T  

    Heart and vessels   2018年11月

     詳細を見る

    記述言語:英語  

    DOI: 10.1007/s00380-018-1295-1

    PubMed

共同研究・競争的資金等の研究課題 1

  1. 加速度センサー搭載型活動量計を用いた日常生活の身体活動強度評価と心房細動アブレーション治療後の予後改善への試み

    2016年 - 2017年

    鈴木謙三記念医科学応用研究財団 研究助成金 

    柳澤 哲

      詳細を見る

    資金種別:競争的資金

科研費 5

  1. 頸動脈波の微小栓子シグナル信号解析を用いた、有効で安全な次世代不整脈治療法の確立

    研究課題/研究課題番号:23K07549  2023年4月 - 2027年3月

    科学研究費補助金   基盤研究(C)

      詳細を見る

    担当区分:研究代表者 

  2. 心房細動アブレーション治療の予後改善をめざした積極的生活習慣改善プログラムの導入

    2016年4月 - 2019年3月

    科学研究費補助金  若手研究(B)

    柳澤 哲

      詳細を見る

    担当区分:研究代表者 

  3. 新しいヒス束ペースメーカの長期予後と刺激伝導系の解明を目指した多施設共同研究

    研究課題/研究課題番号:19K17558  2019年4月 - 2023年3月

    科学研究費助成事業  若手研究

    柳澤 哲

      詳細を見る

    担当区分:研究代表者 

    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    本研究は、新しいペーシングシステムであるヒス束ペーシングの有効性と安全性、さらにその長期的な予後について多施設で検討を行うものである。日本では、ヒス束ペースメーカは臨床診療に導入されてから間もないため、各施設ともまだ症例数が少なく、その適応や効果について模索している段階である。本研究の目的は、ヒス束ペースメーカを対象として前向きに多施設の症例登録・共同研究を行い、多くのヒス束ペースメーカの症例を収集して長期の追跡を行うことで、その有効性と安全性だけでなく、心機能への影響や長期的な予後について検証を行うものである。
    ヒス束ペースメーカは2017年本邦に導入された全く新しいペーシングシステムである。刺激伝導系であるヒス束を直接捕捉・ペーシングすることにより、従来の右心室ペーシングで懸念された非効率的な心室同期不全や、心拍出量低下から引き起こされる心不全発症を回避できる可能性がある。日本では臨床診療に導入されてから間もないため、各施設ともまだ症例数が少なくその適応や効果について模索している段階である。本研究の目的は、ヒス束ペースメーカ症例を対象として前向きで多施設の共同研究を行い、ヒス束ペースメーカの有効性と安全性、心機能への影響や長期的な予後について検証を行うものである。
    今年度は研究プロトコル・計画について、主管実施施設である当病院の生命倫理審査委員会からの承認が下りた。引き続き共同研究機関において、それぞれの倫理審査委員会から研究実施の承認が得られた。最初にWEBシステムでの症例登録システムを構築し、多施設での症例登録や入力がすみやかに行えるように準備と管理を行った。その後症例の登録と研究を開始しており、これまでに約1年間で25例のヒス束ペースメーカシステム植え込み症例の登録が得られた。現在登録完了施設は6施設からなり、年齢も50から80歳台と多岐にわたっている。同時に、個々の症例について6か月後の短期評価項目の調査入力を行っている状況である。また、本研究のデザイン/プロトコル論文を作成して投稿し、日本不整脈心電学会関連の雑誌に掲載となった。
    症例の組み入れ登録を開始しているが、現時点ではやや症例の見積もり数と比較して不足がちな状況である。
    今後も引き続き症例登録を続けて、できるだけ多くの症例登録を目指す。また得られた結果をもとに分析を開始していく予定である。

  4. 心房細動アブレーション治療の予後改善をめざした積極的生活習慣改善プログラムの導入

    研究課題/研究課題番号:16K19399  2016年4月 - 2019年3月

    科学研究費助成事業  若手研究(B)

    柳澤 哲

      詳細を見る

    担当区分:研究代表者 

    配分額:3900000円 ( 直接経費:3000000円 、 間接経費:900000円 )

    加速度センサー搭載型の活動量計を用いて、心房細動カテーテルアブレーション治療前後の運動機能の評価を行った。約半年間の観察期間では、術前に比べて平均1日歩数、最大歩数において増加傾向が認められ、運動強度も増加する傾向が認められた。活動量や運動機能の改善は、アブレーション術後の比較的早期から認められており、心房細動の抑制や血行動態の改善による速やかな運動能力と活動への効果が現れることが確認された。
    本研究は、心房細動アブレーション治療前後の運動機能や活動能力を、活動量計を用いて客観的に評価したものである。その成果として、活動量や運動能力の改善が、アブレーション術後比較的早期から改善していることが判明した。心房細動カテーテルアブレーション治療後では血管穿刺や自律神経への影響もあるが、運動機能と活動量への影響が早期に認められたことは、術後のADL向上や早期社会復帰への指標となりえることが考えられる。

  5. 心電図周波数解析と心内ローターマッピングを用いた新しい心房細動評価と治療法の開発

    研究課題/研究課題番号:15K09076  2015年4月 - 2018年3月

    科学研究費助成事業  基盤研究(C)

    因田 恭也, 室原 豊明, 吉田 直樹, 柳澤 哲, 山崎 正俊

      詳細を見る

    担当区分:研究分担者 

    体表面心電図の心房細動波からDominant Frequency (DF)が得られることが知られている。われわれはアブレーションを行った持続性心房細動患者の予後とDFとの関連を調べた。DFが高いとアブレーション後の再発が多く、DFは心房筋のリモデリングを反映していると考えられた。
    また心房細動中のrotorを観察すると、左心房前壁および後壁にrotorが多く観察され、これらをablationにて焼灼すると、心房細動が停止する症例が認められた。またその後の洞調律維持も良好であった。心房細動rotorの評価は、アブレーション治療時の焼灼部位決定に有用であった。