Updated on 2022/03/17

写真a

 
YANAGISAWA Satoshi
 
Organization
Graduate School of Medicine Department of Advanced Cardiovascular Therapeutics Endowed Chair Designated lecturer
Title
Designated lecturer

Degree 1

  1. 博士(医学) ( 2017.1   名古屋大学 ) 

Research Areas 1

  1. Life Science / Cardiology  / 不整脈学、電気生理学

Professional Memberships 3

  1. 日本不整脈心電学会

  2. 日本内科学会

  3. 日本循環器学会

Committee Memberships 2

  1.   日本内科学会東海支部 評議員  

       

  2.   日本不整脈心電学会 第3期評議員  

       

 

Papers 55

  1. Periprocedural Management of Cardiac Tamponade During Catheter Ablation for AF Under Uninterrupted DOAC and Warfarin

    Yanagisawa S.

    JACC: Clinical Electrophysiology     2020

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    DOI: 10.1016/j.jacep.2020.02.005

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  2. Prothrombotic Responses After Catheter Ablation for Atrial Fibrillation During Uninterrupted Oral Anticoagulant Agent Administration.

      Vol. 5 ( 12 ) page: 1418-1427   2019.12

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    DOI: 10.1016/j.jacep.2019.09.002

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  3. Comparison of the empirical linear ablation and low voltage area-guided ablation in addition to pulmonary vein isolation in patients with persistent atrial fibrillation: a propensity score-matched analysis.

    Suzuki N, Kaneko S, Fujita M, Shinoda M, Kubota R, Ohashi T, Tatami Y, Suzuki J, Hori H, Adachi K, Ito R, Shirai Y, Yanagisawa S, Inden Y, Murohara T

    BMC cardiovascular disorders   Vol. 22 ( 1 ) page: 13   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:BMC Cardiovascular Disorders  

    Background: The efficacy of pulmonary vein isolation (PVI) alone is not guaranteed for persistent atrial fibrillation (PeAF), and it is unclear which type of ablation approach should be applied in addition to PVI. This study aimed to compare outcomes and prognosis between empirical linear ablation and low-voltage area (LVA) ablation after PVI for PeAF. Methods: We enrolled 128 patients with PeAF who were assigned to the linear ablation group (n = 64) and the LVA ablation group (n = 64) using a propensity score-matched model. After PVI and cardioversion, the patients underwent either empirical linear ablation or LVA ablation during sinus rhythm. All patients in the linear ablation group underwent both roof line and mitral valve isthmus (MVI) ablations. An electrical-guided ablation targeting LVA (< 0.5 mV) was performed in the LVA group. When there was no LVA in the LVA group, only PVI was applied. We compared the procedural outcomes and recurrence after ablation between the two groups. Results: The baseline characteristics were well-balanced between the two groups. Fifty patients had LVA (22 and 28 patients in the linear and LVA groups). The roof and MVI lines were completed in 100% and 96.9% of the patients. During the mean follow-up of 279.5 ± 161.3 days, the LVA group had significantly lower recurrence than the linear group (15 patients [23%] vs. 29 patients [45%], p = 0.014). Thirty-five patients were prescribed antiarrhythmic drugs during the follow-up period (linear group, n = 17; LVA group, n = 18); amiodarone and bepridil were administered to most of the patients (15 and 17 patients, respectively). The difference in the prognosis was relevant among the patients with LVA, while this trend was not observed in those without LVA. The LVA ablation group demonstrated significantly lower radiofrequency energy and shorter procedural time compared to the linear ablation group. The recurrence of atrial flutter was more likely to occur in the linear group than in the LVA group (14 [22%] vs. 6 [9.4%], p = 0.052). Conclusion: The electrophysiological-guided LVA ablation is more effective than empirical linear ablation in PeAF patients with LVA. Unnecessary empirical linear ablation might have a risk of iatrogenic gap and atrial flutter recurrence.

    DOI: 10.1186/s12872-022-02460-9

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  4. Efficacy of His Bundle Pacing on LV Relaxation and Clinical Improvement in HF and LBBB.

    Kato H, Yanagisawa S, Sakurai T, Mizuno C, Ota R, Watanabe R, Suga K, Okada T, Murakami H, Kada K, Inden Y, Tsuboi N, Murohara T

    JACC. Clinical electrophysiology   Vol. 8 ( 1 ) page: 59 - 69   2022.1

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    Objectives: This study aimed to compare acute hemodynamic improvements and responses to His bundle pacing (HBP) and conventional biventricular pacing (BVP). Background: HBP can correct left bundle branch block (LBBB) and may be an alternative cardiac resynchronization therapy (CRT) to BVP. Methods: Fourteen consecutive patients with heart failure (HF) and typical LBBB who required CRT were enrolled. The acute hemodynamic responses during HBP and BVP were compared using a micromanometer-tipped catheter inserted into the left ventricle (LV) before CRT. Each configuration was compared with AAI mode. A permanent HBP device was implanted when LBBB correction threshold was ≤1.5 V at 1.0 ms, and remaining patients were treated with BVP. Clinical and echocardiographic improvements were assessed during a 12-month follow-up period. Results: The LV contractile index (positive maximal rate of LV pressure rise [dP/dtmax]) increased similarly during HBP and BVP (18.8% ± 6.4% vs 18.0% ± 10.2%; P = 0.810). LV relaxation indices (negative dP/dtmax and tau) were significantly improved during HBP compared with BVP (negative dP/dtmax: 14.3% ± 5.5% vs 3.1% ± 8.1%; P < 0.001; tau: 7.2% ± 4.3% vs −0.8% ± 8.1%; P = 0.001). Nine (64%) patients received permanent HBP devices, while 5 patients were treated with BVP. The New York Heart Association functional class, LV ejection fraction, LV end-systolic volume, and B-type natriuretic peptide level improved in patients treated with HBP and BVP (all P < 0.05 vs baseline). Patients treated with HBP exhibited earlier and greater improvements of the LV ejection fraction and LV end-systolic volume than did those with BVP. Conclusions: HBP improves systolic function and LV relaxation in patients with HF and LBBB. CRT via HBP produced earlier and greater clinical responses than BVP.

    DOI: 10.1016/j.jacep.2021.06.011

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  5. Usefulness of the Snare Technique During Leadless Pacemaker Implantation for a Patient with a Severely Dilated Right Atrium.

    Hiramatsu T, Mizutani Y, Yanagisawa S, Sugiyama T, Yamashita D, Tajima A, Yonekawa J, Makino Y, Suzuki H, Ichimiya H, Uchida Y, Watanabe J, Kanashiro M, Inden Y, Murohara T

    International heart journal   Vol. 63 ( 1 ) page: 159 - 162   2022

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    We report here the case of a 92-year-old woman with atrial fibrillation bradycardia in which leadless pacemaker implantation was performed with a difficult delivery of the catheter sheath due to an extremely large right atrium. Using a snare technique with correction of the direction of the force on the catheter toward the right ventricle (RV) can result in successful delivery of the pacemaker catheter and stable placement of the pacemaker system in the RV septum. This specific snare technique has the potential to facilitate leadless pacemaker implantation safely in a severely dilated chamber of the heart, making this technique effective to use in clinical practice.

    DOI: 10.1536/ihj.21-499

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  6. Identification of high priority focal activations in persistent atrial fibrillation using a novel mapping strategy.

    Shimojo M, Inden Y, Yanagisawa S, Riku S, Suga K, Furui K, Nakagomi T, Okajima T, Shibata R, Murohara T

    Heart and vessels     2021.10

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    DOI: 10.1007/s00380-021-01977-x

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  7. Short coupling interval with high burden of atrial ectopy predicts recurrence after atrial fibrillation ablation.

    Okajima T, Inden Y, Yanagisawa S, Imai H, Murase Y, Ogawa Y, Kawaguchi K, Murohara T

    Heart and vessels     2021.10

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    DOI: 10.1007/s00380-021-01966-0

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  8. Cryoballoon ablation for atrial fibrillation without the use of a contrast medium: a combination of the intracardiac echocardiography and pressure wave monitoring guided approach.

    Makino Y, Mizutani Y, Yamashita D, Yonekawa J, Satake A, Kurobe M, Hiramatsu T, Ichimiya H, Uchida Y, Watanabe J, Kanashiro M, Ichimiya S, Yanagisawa S, Inden Y, Murohara T

    Heart and vessels     2021.10

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    DOI: 10.1007/s00380-021-01963-3

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  9. Earliest pulmonary vein potential-guided cryoballoon ablation is associated with better clinical outcomes than conventional cryoballoon ablation: A result from two randomized clinical studies.

    Mizutani Y, Yanagisawa S, Kanashiro M, Yamashita D, Yonekawa J, Makino Y, Hiramatsu T, Ichimiya H, Uchida Y, Watanabe J, Ichimiya S, Inden Y, Murohara T

    Journal of cardiovascular electrophysiology     2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jce.15246

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  10. Incidence of Left Atrial Thrombus Development and Imaging Approach in Patients Scheduled for Repeat Catheter Ablation for Atrial Fibrillation.

    Yanagisawa S, Inden Y, Riku S, Suga K, Furui K, Nakagomi T, Shimojo M, Okajima T, Shibata R, Murohara T

    The American journal of cardiology   Vol. 155   page: 52 - 63   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Journal of Cardiology  

    The risk for developing left atrial (LA) thrombi after initial catheter ablation for atrial fibrillation (AF) and requirements for imaging evaluation for thrombi screening at repeat ablation is unclear. This study aimed to assess the occurrence of thrombus development and frequency of any imaging study evaluating thrombus formation during repeat ablation for AF. Of 2,066 patients undergoing initial catheter ablation for AF with uninterrupted oral anticoagulation, 615 patients underwent repeat ablation after 258.0 (105.0–882.0) days. We investigated the factors associated with safety outcomes and requirements for thrombus screening. All patients underwent at least one imaging examination to screen for thrombi in the initial session; however, the examination rate decreased to 476 patients (77%) before the repeat session. The frequency of imaging evaluations was 5.0%, 11%, 21%, 84%, and 91% for transesophageal echocardiography and 18%, 33%, 49%, 98%, and 99% for any imaging modality at repeat ablation performed ≤60 days, ≤90 days, ≤180 days, >180 days, and >1 year after the initial session, respectively. Three patients (0.5%) developed LA thrombi at repeat ablation due to identifiable causes, and no patients experienced thromboembolic events when no imaging evaluation was performed. Multivariate analysis revealed that repeat ablation performed after >180 days, non-paroxysmal atrial arrhythmias, and lower left ventricular ejection fraction were predictors of thrombus development and severe spontaneous echocardiography contrast. In conclusion, the risk for thrombus development at repeat ablation for AF was low. There needs to be a risk stratification of the imaging screening for thrombi at repeat ablation.

    DOI: 10.1016/j.amjcard.2021.06.019

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  11. Permanent His-bundle pacing using distal His-bundle electrogram-guided approach in patients with atrioventricular block.

    Suga K, Kato H, Inden Y, Yanagisawa S, Murakami H, Kada K, Tsuboi N, Murohara T

    Pacing and clinical electrophysiology : PACE     2021.9

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    DOI: 10.1111/pace.14363

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  12. Long P-wave duration immediately after pulmonary vein isolation on radiofrequency catheter ablation for atrial fibrillation predicts clinical recurrence: correlation with atrial remodeling in persistent atrial fibrillation.

    Ohguchi S, Inden Y, Yanagisawa S, Shigematsu T, Yasuda K, Katagiri K, Oguri M, Murohara T

    Heart and vessels     2021.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Heart and Vessels  

    © 2021, Springer Japan KK, part of Springer Nature. P-wave morphology reflects atrial remodeling and indicates prognosis after radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). The impact of p-wave morphology after excluding the effect of pulmonary vein (PV) substrate on outcomes is unknown. We evaluated the p-wave morphology on electrocardiography immediately after PV isolation for clinical outcomes. Eighty-four consecutive patients (47 with paroxysmal AF and 37 with persistent AF) who underwent RFCA were included. P-wave duration (PWD) and amplitude in all leads were examined during sinus rhythm immediately after PV isolation. We evaluated the relationship between electrocardiogram parameters and AF recurrence, according to the type of AF and following ablation, and the correlation with left atrial (LA) volume, low voltage ratio, and fixed conduction time. During 12 months of follow-up, 20 patients experienced recurrence. The cut-off value of PWD > 120 ms in lead I showed a sensitivity of 75% and specificity of 69% for predicting recurrence. PWD was significantly correlated with LA volume, low voltage, and conduction velocity. Significantly higher recurrence rates were observed in patients with PWD > 120 ms than in those with PWD ≤ 120 ms (p < 0.001), and the difference was more pronounced in patients with persistent AF. Multivariate analysis demonstrated that PWD > 120 ms was independently associated with recurrence in the total population (hazard ratio 2.00; 95% confidence interval 1.27–3.22; p = 0.003) and in patients with persistent AF. In conclusion, long PWD after PV isolation predicts AF recurrence, which might be associated with the extent of the LA substrate in persistent AF.

    DOI: 10.1007/s00380-021-01932-w

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  13. Impact of Preoperative Nutritional Status on the Outcome of Catheter Ablation for Atrial Fibrillation.

    Furui K, Morishima I, Morita Y, Kanzaki Y, Takagi K, Nagai H, Watanabe N, Yoshioka N, Yamauchi R, Miyazawa H, Yanagisawa S, Inden Y, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society     2021.8

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    DOI: 10.1253/circj.CJ-21-0218

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  14. Dynamic Changes in Electrocardiogram Parameters After Epicardial Substrate Catheter Ablation of Brugada Syndrome.

    Mamiya K, Inden Y, Yanagisawa S, Fujii A, Tomomatsu T, Okamoto H, Riku S, Suga K, Furui K, Nakagomi T, Shibata R, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 85 ( 8 ) page: 1283 - 1293   2021.7

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    Background: Catheter ablation (CA) is effective for recurrent episodes of ventricular fibrillation (VF) in Brugada syndrome (BrS). VF development in BrS is associated with several electrocardiogram (ECG) abnormalities. This study investigated changes in ECG parameters in high-risk BrS patients who underwent epicardial CA. Methods and Results: In all, 27 BrS patients were implanted with an implantable cardioverter-defibrillator (ICD). Patients were divided into 2 groups: (1) an ablation group (n=11) that underwent epicardial CA because of VF recurrence; and (2) a primary prevention (PP) group (n=16) with ICD implantation only. ECG parameters were evaluated before and 12 months after CA and compared with ECG parameters in the PP group. The T wave peak-to-end interval was significantly longer and the number of abnormal spikes in leads V1-V3 at the second, third, and fourth intercostal spaces was greater in the ablation than PP group. After ablation, ST levels and the sum of abnormal spikes in leads V1-V3 were significantly decreased. The mean (±SD) number of ICD shocks decreased markedly during a mean follow-up period of 42.0 months (from 3.8±3.7 to 0.2±0.4/year). Four patients had an ICD shock following the ablation procedure. Greater reductions in ST-segment elevation and abnormal spikes were observed in the group without than with VF recurrence. Conclusions: Improvements in surface ECG parameters appear to be associated with successful ablation in high-risk BrS patients.

    DOI: 10.1253/circj.CJ-20-1060

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  15. Comparison of medically versus surgically treated acute type a aortic dissection in patients &lt;80 years old versus patients ≥80 years old.

    Yanagisawa S, Yuasa T, Suzuki N, Hirai T, Yasuda N, Miki K, Yasuura K, Horiuchi K, Tanaka T

    The American journal of cardiology   Vol. 108 ( 3 ) page: 453 - 9   2011.8

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    DOI: 10.1016/j.amjcard.2011.03.067

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  16. Early improvement of daily physical activity after catheter ablation for atrial fibrillation in an accelerometer assessment: A prospective pilot study

    Yanagisawa S.

    Annals of Noninvasive Electrocardiology   Vol. 26 ( 1 )   2021.1

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    DOI: 10.1111/anec.12807

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  17. A case of heart failure complicated with double ventricular response triggered by beta blocker

    Kazama S.

    HeartRhythm Case Reports     2021

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    DOI: 10.1016/j.hrcr.2020.12.004

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  18. The mechanism and prognosis of acute and late improvement in mitral regurgitation after cardiac resynchronization therapy

    Okamoto H.

    Heart and Vessels     2021

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    Publishing type:Research paper (scientific journal)   Publisher:Heart and Vessels  

    DOI: 10.1007/s00380-021-01771-9

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  19. Disappearance pattern and the last remaining earliest pulmonary vein potential during cryoballoon ablation in predicting recurrence and conduction gap site of pulmonary veins

    Mizutani Y.

    Heart and Vessels     2021

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    Publishing type:Research paper (scientific journal)   Publisher:Heart and Vessels  

    DOI: 10.1007/s00380-021-01785-3

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  20. Safety and efficacy of first-line cryoablation for para-hisian ventricular arrhythmias using a cryomapping protocol approach: A case series

    Mizutani Y.

    Clinical Case Reports   Vol. 8 ( 12 ) page: 3248 - 3253   2020.12

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    Publishing type:Research paper (scientific journal)   Publisher:Clinical Case Reports  

    DOI: 10.1002/ccr3.3401

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  21. Autopsy evaluation of the implantation site of a His bundle pacing lead demonstrating selective capture

    Kato H.

    PACE - Pacing and Clinical Electrophysiology   Vol. 43 ( 11 ) page: 1412 - 1416   2020.11

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    DOI: 10.1111/pace.13989

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  22. The impact of the dominant frequency of body surface electrocardiography in patients with persistent atrial fibrillation

    Murase Y.

    Heart and Vessels   Vol. 35 ( 7 ) page: 967 - 976   2020.7

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    DOI: 10.1007/s00380-020-01563-7

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  23. Electrocardiogram characteristics of P wave associated with successful pulmonary vein isolation in patients with paroxysmal atrial fibrillation: Significance of changes in P-wave duration and notched P wave

    Yanagisawa Satoshi, Inden Yasuya, Okamoto Hiroya, Fujii Aya, Sakamoto Yusuke, Mamiya Keita, Tomomatsu Toshiro, Shibata Rei, Murohara Toyoaki

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   Vol. 25 ( 2 ) page: e12712   2020.3

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    DOI: 10.1111/anec.12712

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  24. Anatomical assessment of crosstalk phenomenon during laser balloon ablation with imaging in a patient with unusual atrial hypertrophy

    Yanagisawa Satoshi, Inden Yasuya, Okamoto Hiroya, Tomomatsu Toshiro, Fujii Aya, Mamiya Keita, Shibata Rei, Murohara Toyoaki

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 57 ( 1 ) page: 157-159   2020.1

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    DOI: 10.1007/s10840-019-00632-w

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  25. Study design and protocol for evaluating the long-term prognosis of patients receiving his bundle pacing: A multicenter observational study

    Yanagisawa S.

    Journal of Arrhythmia   Vol. 35 ( 5 ) page: 760 - 765   2019.10

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    Publishing type:Research paper (scientific journal)   Publisher:Journal of Arrhythmia  

    DOI: 10.1002/joa3.12229

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  26. Correction to: Differences in prothrombotic response between the uninterrupted and interrupted apixaban therapies in patients undergoing cryoballoon ablation for paroxysmal atrial fibrillation: a randomized controlled study (Heart and Vessels, (2019), 34, 9, (1533-1541), 10.1007/s00380-019-01370-9)

    Ando M.

    Heart and Vessels   Vol. 34 ( 9 )   2019.9

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    DOI: 10.1007/s00380-019-01424-y

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  27. Differences in prothrombotic response between the uninterrupted and interrupted apixaban therapies in patients undergoing cryoballoon ablation for paroxysmal atrial fibrillation: a randomized controlled study

    Ando M.

    Heart and Vessels   Vol. 34 ( 9 ) page: 1533 - 1541   2019.9

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    DOI: 10.1007/s00380-019-01370-9

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  28. Discontinuous contraction in the left ventricle assessed by 2-D speckle tracking echocardiography benefits from CRT

    Fujii A.

    PACE - Pacing and Clinical Electrophysiology   Vol. 42 ( 9 ) page: 1204 - 1212   2019.9

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    DOI: 10.1111/pace.13759

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  29. T-wave changes of cardiac memory caused by frequent premature ventricular contractions originating from the right ventricular outflow tract

    Sakamoto Y.

    Journal of Cardiovascular Electrophysiology   Vol. 30 ( 9 ) page: 1549 - 1556   2019.9

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    Publishing type:Research paper (scientific journal)   Publisher:Journal of Cardiovascular Electrophysiology  

    DOI: 10.1111/jce.14008

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  30. Identification of precise accessory pathway using ultra-high-resolution three-dimensional mapping system: utility and feasibility in preliminary experience

    Yanagisawa S.

    Journal of Interventional Cardiac Electrophysiology   Vol. 55 ( 2 ) page: 241 - 242   2019.8

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    DOI: 10.1007/s10840-019-00582-3

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  31. His bundle pacing with unusual automaticity

    Yanagisawa Satoshi, Inden Yasuya, Shibata Rei, Murohara Toyoaki

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   Vol. 30 ( 6 ) page: 966-968   2019.6

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    DOI: 10.1111/jce.13904

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  32. Adjacentmultiple accessory pathways demonstrated on ultra-high-resolution mapping

    Yanagisawa Satoshi, Inden Yasuya, Murohara Toyoaki

    EUROPACE   Vol. 21 ( 5 ) page: 723-723   2019.5

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    DOI: 10.1093/europace/euz044

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  33. Uninterrupted Direct Oral Anticoagulant and Warfarin Administration in Elderly Patients Undergoing Catheter Ablation for Atrial Fibrillation: A Comparison With Younger Patients.

    Yanagisawa S, Inden Y, Fujii A, Ando M, Funabiki J, Murase Y, Takenaka M, Otake N, Ikai Y, Sakamoto Y, Shibata R, Murohara T

    JACC. Clinical electrophysiology   Vol. 4 ( 5 ) page: 592-600   2018.5

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    DOI: 10.1016/j.jacep.2018.02.013

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  34. Renal function and risk of stroke and bleeding in patients undergoing catheter ablation for atrial fibrillation: Comparison between uninterrupted direct oral anticoagulants and warfarin administration

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Ikai Yoshihiro, Sakamoto Yusuke, Shibata Rei, Murohara Toyoaki

    HEART RHYTHM   Vol. 15 ( 3 ) page: 348-354   2018.3

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    DOI: 10.1016/j.hrthm.2017.10.033

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  35. Assessment of autonomic nervous system modulation after novel catheter ablation techniques for atrial fibrillation using multiple short-term electrocardiogram recordings

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Kamikubo Yosuke, Kanzaki Yasunori, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Ikai Yoshihiro, Sakamoto Yusuke, Shibata Rei, Murohara Toyoaki

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 51 ( 1 ) page: 35-44   2018.1

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    DOI: 10.1007/s10840-017-0295-x

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  36. Vagal response in cryoballoon ablation of atrial fibrillation and autonomic nervous system: Utility of epicardial adipose tissue location

    Yanagisawa Satoshi, Inden Yasuya, Mizutani Yoshiaki, Fujii Aya, Kamikubo Yosuke, Kanzaki Yasunori, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Hattori Tetsuyoshi, Shibata Rei, Murohara Toyoaki

    JOURNAL OF ARRHYTHMIA   Vol. 33 ( 4 ) page: 275-282   2017.8

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    DOI: 10.1016/j.joa.2017.03.001

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  37. Impaired renal function is associated with recurrence after cryoballoon catheter ablation for paroxysmal atrial fibrillation: A potential effect of non-pulmonary vein foci.

    Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Ando M, Hirai M, Shibata R, Murohara T.

    J Cardiol.   Vol. 69 ( 1 ) page: 3-10   2017.1

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  38. An ECG Index of P-Wave Force Predicts the Recurrence of Atrial Fibrillation after Pulmonary Vein Isolation

    Kanzaki Y.

    PACE - Pacing and Clinical Electrophysiology   Vol. 39 ( 11 ) page: 1191 - 1197   2016.11

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    DOI: 10.1111/pace.12956

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  39. Effect and Significance of Early Reablation for the Treatment of Early Recurrence of Atrial Fibrillation After Catheter Ablation. Reviewed

    Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Ando M, Hirai M, Shibata R, Murohara T.

    Am J Cardiol.   Vol. 118 ( 6 ) page: 833-841   2016.9

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  40. Decrease in B-Type Natriuretic Peptide Levels and Successful Catheter Ablation for Atrial Fibrillation in Patients with Heart Failure. Reviewed

    Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Hirai M, Murohara T.

    Pacing Clin Electrophysiol.   Vol. 39 ( 3 ) page: 225-234   2016.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pace.12788

  41. Elevated Red Blood Cell Distribution Width Predicts Recurrence After Catheter Ablation for Atrial Fibrillation in Patients With Heart Failure - Comparison With Non-Heart Failure Patients. Reviewed

    Yanagisawa S, Inden Y, Kato H, Miyoshi A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Hirai M, Murohara T.

    Circ J.   Vol. 80 ( 3 ) page: 627-638   2016.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-15-1152

  42. Differences in activated clotting time among uninterrupted anticoagulants during the periprocedural period of atrial fibrillation ablation

    Nagao T.

    Heart Rhythm   Vol. 12 ( 9 ) page: 1972 - 1978   2015.9

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    Publishing type:Research paper (scientific journal)   Publisher:Heart Rhythm  

    DOI: 10.1016/j.hrthm.2015.04.016

    Scopus

  43. Impact of cardiac resynchronization therapy-defibrillator implantation on the association between body mass index and prognosis in patients with heart failure. Reviewed

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Ishikawa S, Kato H, Okumura S, Miyoshi-Fujii A, Nagao T, Yamamoto T, Mizutani Y, Ito T, Hirai M, Murohara T.

    J Interv Card Electrophysiol.   Vol. 43 ( 3 ) page: 269-277   2015.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  44. Alogliptin, a dipeptidyl peptidase-4 inhibitor, regulates the atrial arrhythmogenic substrate in rabbits

    Yamamoto T.

    Heart Rhythm   Vol. 12 ( 6 ) page: 1362 - 1369   2015.6

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    Publishing type:Research paper (scientific journal)   Publisher:Heart Rhythm  

    DOI: 10.1016/j.hrthm.2015.03.010

    Scopus

  45. Efficacy and safety of Apixaban in the patients undergoing the ablation of atrial fibrillation

    Nagao T.

    PACE - Pacing and Clinical Electrophysiology   Vol. 38 ( 2 ) page: 155 - 163   2015.2

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    Publishing type:Research paper (scientific journal)   Publisher:PACE - Pacing and Clinical Electrophysiology  

    DOI: 10.1111/pace.12553

    Scopus

  46. Body mass index is associated with prognosis in Japanese elderly patients with atrial fibrillation: an observational study from the outpatient clinic. Reviewed

    Yanagisawa S, Inden Y, Yoshida N, Kato H, Miyoshi-Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Hirai M, Murohara T.

    Heart Vessels     2015

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00380-015-0765-y

  47. Feasibility and safety of uninterrupted dabigatran therapy in patients undergoing ablation for atrial fibrillation

    Nagao T.

    Internal Medicine   Vol. 54 ( 10 ) page: 1167 - 1173   2015

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    Publishing type:Research paper (scientific journal)   Publisher:Internal Medicine  

    DOI: 10.2169/internalmedicine.54.3520

    Scopus

  48. Clinical characteristics and predictors of super-response to cardiac resynchronization therapy: a combination of predictive factors. Reviewed

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Fujita M, Ohguchi S, Ishikawa S, Kato H, Okumura S, Miyoshi A, Nagao T, Yamamoto T, Hirai M, Murohara T.

    Pacing Clin Electrophysiol.   Vol. 37 ( 11 ) page: 1553-1564   2014.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  49. Clinical outcome of implantable cardioverter defibrillators with recalled and non-recalled leads in Japanese patients. Increased failure rate of the Sprint Fidelis lead. Reviewed

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Ichiyanagi H, Fujita M, Ohguchi S, Ishikawa S, Kato H, Okumura S, Miyoshi A, Nagao T, Yamamoto T, Hirai M, Murohara T.

    Circ J.   Vol. 78 ( 2 ) page: 353-359   2014.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  50. Comparison of medically versus surgically treated acute type a aortic dissection in patients <80 years old versus patients >=80 years old. Reviewed

    Yanagisawa S, Yuasa T, Suzuki N, Hirai T, Yasuda N, Miki K, Yasuura K, Horiuchi K, Tanaka T.

    Am J Cardiol.   Vol. 108 ( 3 ) page: 453-459   2011.8

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  51. The prognostic value of treadmill exercise testing in very elderly patients: Heart rate recovery as a predictor of mortality in octogenarians. Reviewed

    Yanagisawa S, Miki K, Yasuda N, Hirai T, Suzuki N, Tanaka T.

    Europace.   Vol. 13 ( 1 ) page: 114-120   2011.1

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  52. Clinical outcomes and prognostic factor for acute heart failure in nonagenarians: Impact of hypoalbuminemia on mortality. Reviewed

    Yanagisawa S, Miki K, Yasuda N, Hirai T, Suzuki N, Tanaka T.

    Int J Cardiol.   Vol. 145 ( 3 ) page: 574-576   2010.12

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  53. Poor tolerance of beta-blockers by elderly patients with heart failure. Reviewed

    Yanagisawa S, Suzuki N, Tanaka T.

    Clin Interv Aging.   Vol. 5   page: 365-368   2010.11

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  54. Right ventricular outflow tract obstruction: metastatic thyroid carcinoma. Reviewed

    Yanagisawa S, Suzuki Y, Yuasa T, Tanaka T.

    J Am Coll Cardiol.   Vol. 55 ( 11 ) page: 1159   2010.3

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  55. Clinical diagnosis of Schistosoma japonicum infection complicating infective endocarditis and liver cirrhosis. Reviewed

    Yanagisawa S, Yuasa T, Tanaka T.

    Intern Med.   Vol. 44 ( 11 ) page: 1001-1005   2010

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▼display all

Books 2

  1. 人体のメカニズムから学ぶ臨床工学 循環器治療学 頻脈性不整脈の発生機序

    柳澤 哲、室原豊明( Role: Joint author)

    メジカルビュー社  2017 

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    Total pages:7   Language:Japanese Book type:Textbook, survey, introduction

  2. BIO Clinica, TOPICS 心房細動カテーテルアブレーション治療の周術期抗凝固療法

    柳澤 哲( Role: Joint author)

    北隆館  2018.11 

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    Language:Japanese Book type:Scholarly book

MISC 2

  1. Myocardial viability as shown by left ventricular lead pacing threshold and improved dyssynchrony by QRS narrowing predicts the response to cardiac resynchronization therapy. Reviewed

    Takenaka M, Inden Y, Yanagisawa S, Fujii A, Ando M, Funabiki J, Murase Y, Otake N, Sakamoto Y, Shibata R, Murohara T

    Journal of cardiovascular electrophysiology     2018.12

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    Language:English  

    DOI: 10.1111/jce.13806

    PubMed

  2. Clinical significance of the timing of early recurrence of atrial arrhythmia after pulmonary vein isolation: a two-institution clinical study. Reviewed

    Murase Y, Inden Y, Imai H, Kyo S, Yanagisawa S, Fujii A, Sakamoto Y, Tomomatsu T, Murohara T

    Heart and vessels     2018.11

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    Language:English  

    DOI: 10.1007/s00380-018-1295-1

    PubMed

Research Project for Joint Research, Competitive Funding, etc. 1

  1. 加速度センサー搭載型活動量計を用いた日常生活の身体活動強度評価と心房細動アブレーション治療後の予後改善への試み

    2016 - 2017

    鈴木謙三記念医科学応用研究財団 研究助成金 

    柳澤 哲

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. 心房細動アブレーション治療の予後改善をめざした積極的生活習慣改善プログラムの導入

    2016.4 - 2019.3

    科学研究費補助金  若手研究(B)

    柳澤 哲

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    Authorship:Principal investigator 

  2. 新しいヒス束ペースメーカの長期予後と刺激伝導系の解明を目指した多施設共同研究

    Grant number:19K17558  2019.4 - 2023.3

    科学研究費助成事業  若手研究

    柳澤 哲

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    本研究は、新しいペーシングシステムであるヒス束ペーシングの有効性と安全性、さらにその長期的な予後について多施設で検討を行うものである。日本では、ヒス束ペースメーカは臨床診療に導入されてから間もないため、各施設ともまだ症例数が少なく、その適応や効果について模索している段階である。本研究の目的は、ヒス束ペースメーカを対象として前向きに多施設の症例登録・共同研究を行い、多くのヒス束ペースメーカの症例を収集して長期の追跡を行うことで、その有効性と安全性だけでなく、心機能への影響や長期的な予後について検証を行うものである。
    ヒス束ペースメーカは2017年本邦に導入された全く新しいペーシングシステムである。刺激伝導系であるヒス束を直接捕捉・ペーシングすることにより、従来の右心室ペーシングで懸念された非効率的な心室同期不全や、心拍出量低下から引き起こされる心不全発症を回避できる可能性がある。日本では臨床診療に導入されてから間もないため、各施設ともまだ症例数が少なくその適応や効果について模索している段階である。本研究の目的は、ヒス束ペースメーカ症例を対象として前向きで多施設の共同研究を行い、ヒス束ペースメーカの有効性と安全性、心機能への影響や長期的な予後について検証を行うものである。
    今年度は研究プロトコル・計画について、主管実施施設である当病院の生命倫理審査委員会からの承認が下りた。引き続き共同研究機関において、それぞれの倫理審査委員会から研究実施の承認が得られた。最初にWEBシステムでの症例登録システムを構築し、多施設での症例登録や入力がすみやかに行えるように準備と管理を行った。その後症例の登録と研究を開始しており、これまでに約1年間で25例のヒス束ペースメーカシステム植え込み症例の登録が得られた。現在登録完了施設は6施設からなり、年齢も50から80歳台と多岐にわたっている。同時に、個々の症例について6か月後の短期評価項目の調査入力を行っている状況である。また、本研究のデザイン/プロトコル論文を作成して投稿し、日本不整脈心電学会関連の雑誌に掲載となった。
    症例の組み入れ登録を開始しているが、現時点ではやや症例の見積もり数と比較して不足がちな状況である。
    今後も引き続き症例登録を続けて、できるだけ多くの症例登録を目指す。また得られた結果をもとに分析を開始していく予定である。

  3. Lifestyle intervention for improvement of the outcome after catheter ablation for atrial fibrillation

    Grant number:16K19399  2016.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Yanagisawa Satoshi

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    Authorship:Principal investigator 

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    The present study was aimed to evaluate physical activities and motor function by using an accelerometer in patients who underwent catheter ablation for atrial fibrillation. After the follow-up period of 6 months, mean daily steps and maximum daily steps were increased from pre-ablation to post-ablation procedure. Moreover, the exercise intensity was increased after the ablation. The improvement of physical activities and motor function was found in the early phase after the ablation procedure. The results may be explained by the effect of suppressing atrial fibrillation and improvement of cardiac hemodynamics.

  4. Evaluation by Frequency Analysis of Surface Electrocardiogram and Rotor Mapping in Left Atrum

    Grant number:15K09076  2015.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Yasuya Inden

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    Authorship:Coinvestigator(s) 

    Dominant frequency (DF) of atrial fibrillation (AF) reflects atrial electrical activity. We retrospectively investigated 78 patients who underwent catheter ablation due to persistent AF. The high DF of lead aVL and V1 was a predictor of arrhythmia recurrence after persistent AF ablation.
    Electrical rotors may be targets in ablations for persistent atrial fibrillation. Unipolar electrograms in left atrium were recorded with using basket catheter, and we analyzed rotational activities by NavX. rotors were recognized in anterior and posterior LA. We performed PV isolation and delivered RF application to the rotors. AF terminated in some patients and more patients maintained sinus rhythm. Rotors could be able to be recognized by use of basket catheter and EnSite system in patients with persistent AF and may be the target of ablation in persistent AF next to PVI.