Updated on 2026/09/02

写真a

 
YANAGISAWA Satoshi
 
Organization
Graduate School of Medicine Department of Advanced Cardiovascular Therapeutics Endowed Chair Designated Lecturer
Title
Designated Lecturer

Degree 1

  1. 博士(医学) ( 2017.1   名古屋大学 ) 

Research Interests 5

  1. 心房細動

  2. 電気生理学

  3. ペースメーカ

  4. カテーテルアブレーション

  5. 不整脈

Research Areas 1

  1. Life Science / Cardiology  / 不整脈学、電気生理学

Professional Memberships 6

  1. 日本不整脈心電学会

  2. 日本内科学会

  3. 日本循環器学会

  4. Asia Pacific Heart Rhythm Society (APHRS)

  5. European Heart Rhythm Association (EHRA)

  6. European Society of Cardiology (ESC)

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Committee Memberships 7

  1.   日本内科学会東海支部 評議員  

       

  2.   日本不整脈心電学会 第3期評議員  

       

  3.   EP Europace: International Editorial Consultant Board  

       

  4.   Fellow of the European Heart Rhythm Association (FEHRA)  

       

  5.   Fellow of the European Society of Cardiology (FESC)  

       

  6.   Fellow of Japanese Circulation Society (FJCS)  

       

  7.   Editorial Board of the Journal of Cardiovascular Electrophysiology (JCE)  

       

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Papers 162

  1. Patient vulnerability associated with acute kidney injury after pulsed field ablation: A role for baseline biomarkers and haptoglobin phenotype.

    Suga K, Kato H, Yamazaki K, Sakurai T, Yamazoe S, Tsuzuki K, Ota T, Murakami H, Kada K, Tsuboi N, Yanagisawa S, Inden Y, Murohara T

    Heart rhythm   Vol. 23 ( 9 ) page: e1907 - e1915   2026.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.hrthm.2026.04.028

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  2. Comparative analysis of hemolysis incidence across 3 different pulsed field ablation systems.

    Miyazawa H, Yanagisawa S, Inden Y, Fukushima T, Hiramatsu T, Adachi K, Teraoka T, Ota R, Miyamae K, Tanaka Y, Shimojo M, Tsuji Y, Murohara T

    Heart rhythm O2   Vol. 7 ( 8 ) page: 1407 - 1415   2026.8

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    DOI: 10.1016/j.hroo.2026.04.009

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  3. Enhanced contact of the PulseSelect catheter using the contact index during pulmonary vein isolation.

    Mizutani Y, Fujiwara G, Yanagisawa S, Murohara T

    Heart rhythm   Vol. 23 ( 8 ) page: 1862 - 1863   2026.8

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    DOI: 10.1016/j.hrthm.2025.08.039

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  4. Temporal Coagulation Biomarker Profiles After Andexanet Alfa Use for Procedure-Related Cardiac Tamponade.

    Shimojo M, Inden Y, Kitahara T, Hiramatsu S, Tanaka Y, Hiramatsu T, Fukushima T, Adachi K, Teraoka T, Ota R, Yanagisawa S, Tsuji Y

    Journal of cardiovascular electrophysiology   Vol. 37 ( 8 ) page: 1808 - 1816   2026.8

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    DOI: 10.1111/jce.70415

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  5. Contact Index for PulseSelect Catheter Apposition: Validation by Transesophageal Echocardiography.

    Fujiwara G, Mizutani Y, Yanagisawa S, Murohara T

    Pacing and clinical electrophysiology : PACE     2026.7

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    DOI: 10.1111/pace.70376

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  6. Differential Time Course of LVEF Recovery Between Conduction System Pacing Versus Biventricular Pacing.

    Kato H, Yanagisawa S, Sakurai T, Suga K, Murakami H, Kada K, Tsuboi N, Ota R, Inden Y, Murohara T

    JACC. Asia   Vol. 6 ( 7 ) page: 1282 - 1285   2026.7

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    DOI: 10.1016/j.jacasi.2026.03.020

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  7. Novel technique for leadless pacemaker implantation in the small right atrial appendage: a case report.

    Watanabe H, Mizutani Y, Watanabe J, Yanagisawa S, Murohara T

    European heart journal. Case reports   Vol. 10 ( 7 ) page: ytag514   2026.7

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    DOI: 10.1093/ehjcr/ytag514

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  8. Smartphone-Based Remote Monitoring for Cardiac Implantable Electronic Devices: Transmission Performance and Early Alert Responsiveness.

    Yanagisawa S, Inden Y, Hibino M, Sato Y, Narita Y, Miyazawa H, Miyamae K, Fukushima T, Hiramatsu T, Adachi K, Teraoka T, Ota R, Tanaka Y, Shimojo M, Tsuji Y, Okumura T, Murohara T

    JACC. Asia   Vol. 6 ( 7 ) page: 1286 - 1289   2026.7

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    DOI: 10.1016/j.jacasi.2026.04.028

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  9. Optimal Timing for Oral Anticoagulant Discontinuation and Prognosis After Successful Catheter Ablation for Atrial Fibrillation.

    Iwawaki T, Yanagisawa S, Inden Y, Miyamae K, Miyazawa H, Goto T, Kondo S, Tachi M, Fukushima T, Hiramatsu T, Adachi K, Teraoka T, Ota R, Shimojo M, Tsuji Y, Okumura T, Murohara T

    JACC. Clinical electrophysiology   Vol. 12 ( 7 ) page: 1632 - 1647   2026.7

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    DOI: 10.1016/j.jacep.2026.02.027

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  10. Deep Learning Model for High-Accuracy Classification of Premature Ventricular Contractions With Precordial Transition Zones in Leads V3 or V4.

    Miyamae K, Inden Y, Shimojo M, Miyazawa H, Iwawaki T, Tachi M, Kondo S, Goto T, Yanagisawa S, Tsuji Y, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 90 ( 7 ) page: 773 - 782   2026.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-25-0534

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  11. Long-Term Prognosis and Outcomes in Patients Undergoing His Bundle Pacing Implantation - A Multicenter, Prospective Observational Study in Japan.

    Yanagisawa S, Kato H, Kanzaki Y, Murase Y, Fujita M, Nakagomi T, Ishikawa S, Kamikubo Y, Suzuki H, Murakami H, Morishima I, Imai H, Kaneko S, Yoshida Y, Okumura T, Shibata R, Inden Y, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 90 ( 7 ) page: 871 - 880   2026.6

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    DOI: 10.1253/circj.CJ-26-0196

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  12. Successful Sealing of Steam Pop-Related Left Ventricular Summit Perforation With Partial Impella Support.

    Miyazawa H, Inden Y, Shimojo M, Yanagisawa S, Kazama S, Kondo T, Morimoto R, Yoshizumi T, Mutsuga M, Murohara T

    JACC. Case reports   Vol. 31 ( 24 ) page: 108340   2026.6

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    DOI: 10.1016/j.jaccas.2026.108340

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  13. Prospective observational study of the effect of catheter ablation among patients with heart failure with preserved ejection fraction and persistent atrial fibrillation: Findings from BENEFIT-HFpEF.

    Oishi H, Kondo T, Ito R, Kazama S, Haga T, Murase Y, Yamaguchi S, Furui K, Kaneko S, Imai H, Takemoto K, Kobayashi K, Kato T, Suzuki H, Imaizumi T, Hiraiwa H, Morimoto R, Shimojo M, Yanagisawa S, Inden Y, Murohara T

    Heart and vessels     2026.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00380-026-02716-w

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  14. Evaluation of Participant Characteristics and Short-Term Outcomes in a Community-Based Hypertension Awareness Event in Japan.

    Taguchi N, Yanagisawa S, Tsunekawa K, Ota R, Suzuki M, Miyagawa E, Miyahara H, Takemoto S, Murohara T

    International heart journal   Vol. 67 ( 3 ) page: 289 - 291   2026.5

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    DOI: 10.1536/ihj.26-054

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  15. Efficacy of cardiac resynchronization therapy on cardiac sarcoidosis: Insight into mechanism of mechanical response and the role of myocardial work.

    Kondo S, Inden Y, Yanagisawa S, Miyamae K, Miyazawa H, Goto T, Tachi M, Iwawaki T, Shimojo M, Tsuji Y, Murohara T

    Heart rhythm   Vol. 23 ( 5 ) page: 1187 - 1195   2026.5

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    DOI: 10.1016/j.hrthm.2025.05.030

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  16. Low Perfusion in Heart Failure: The Invisible Half of Hemodynamics at Discharge.

    Okumura T, Hiraiwa H, Yanagisawa S, Murohara T

    Cardiology     page: 1 - 4   2026.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000551157

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  17. Time-course changes in autonomic nervous system activity after pulsed-field ablation for paroxysmal atrial fibrillation: comparison with cryoballoon ablation.

    Fukushima T, Yanagisawa S, Inden Y, Suzuki N, Hiramatsu T, Adachi K, Teraoka T, Ota R, Miyamae K, Miyazawa H, Shimojo M, Tsuji Y, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing     2026.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10840-026-02321-x

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  18. Comparison of left bundle branch area pacing and biventricular pacing for atrioventricular block with heart failure and mild-to-moderately reduced left ventricular systolic function: design and rationale of the BLOCK NAGOYA randomized clinical trial.

    Kato H, Yanagisawa S, Morishima I, Kanzaki Y, Suzuki H, Takasugi N, Sato K, Warita S, Naruse Y, Yokoi K, Ishikawa S, Sugiura S, Mizutani Y, Kamikubo Y, Goto T, Murase Y, Sakamoto Y, Yoshimoto D, Funabiki J, Kuwatsuka Y, Ando M, Okumura T, Inden Y, Murohara T, BLOCK NAGOYA study investigators

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   Vol. 69 ( 2 ) page: 297 - 307   2026.3

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    DOI: 10.1007/s10840-025-02210-9

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  19. Decreased left ventricular systolic function during the late phase after response to cardiac resynchronization therapy.

    Iwawaki T, Inden Y, Yanagisawa S, Miyamae K, Miyazawa H, Goto T, Kondo S, Tachi M, Shimojo M, Tsuji Y, Murohara T

    Heart rhythm   Vol. 23 ( 1 ) page: 149 - 157   2026.1

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    DOI: 10.1016/j.hrthm.2025.02.002

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  20. Renaissance of Physical Examination in Hemodynamic Heart Failure Assessment.

    Okumura T, Hiraiwa H, Yanagisawa S, Murohara T

    Cardiology   Vol. 151 ( 3 ) page: 322 - 325   2026

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000546543

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  21. The Gut-Heart Axis in Heart Failure: Emerging Evidence and Therapeutic Implications.

    Okumura T, Hiraiwa H, Yanagisawa S, Murohara T

    Cardiology   Vol. 151 ( 3 ) page: 326 - 328   2026

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    DOI: 10.1159/000546542

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  22. Cryoballoon Ablation in Older Patients With Heart Failure: Insights From a Large-Scale Multicenter Clinical Study.

    Miyazawa H, Yanagisawa S, Suzuki H, Yoshida Y, Morishima I, Kanzaki Y, Ishikawa S, Kamikubo Y, Kato H, Mizutani Y, Okumura S, Murase Y, Nakasuka K, Warita S, Sekimoto S, Takemoto Y, Takasugi N, Ohguchi S, Senga M, Yokoi K, Ando M, Watanabe R, Ogura Y, Suzuki N, Funabiki J, Shibata R, Inden Y, Murohara T

    JACC. Advances   Vol. 4 ( 12 Pt 1 ) page: 102244   2025.12

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    DOI: 10.1016/j.jacadv.2025.102244

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  23. Difficult ventilation with suspected laryngospasm in patients undergoing pulsed field ablation for atrial fibrillation under general anesthesia using laryngeal mask airway: A case series.

    Suga K, Kato H, Murakami H, Yanagisawa S, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 11 ( 12 ) page: 1271 - 1275   2025.12

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    DOI: 10.1016/j.hrcr.2025.08.021

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  24. Difference in Microembolic Signals Between Flex-Tip Versus Non-Flex-Tip Type Catheters During High-Power Short-Duration Ablation.

    Mizutani Y, Yanagisawa S, Ichikawa M, Nishio K, Sakai H, Nonokawa D, Makino Y, Suzuki H, Ichimiya H, Uchida Y, Watanabe J, Kanashiro M, Iwawaki T, Kondo S, Yuki Sato, Shibata R, Inden Y, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 36 ( 11 ) page: 2919 - 2930   2025.11

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    DOI: 10.1111/jce.70074

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  25. Efficacy of Delivery Catheter for the Right Ventricular Septal Placement of a Defibrillator Lead.

    Kato H, Yamazaki K, Sakurai T, Yamazoe S, Tsuzuki K, Suga K, Ota T, Murakami H, Kada K, Tsuboi N, Yanagisawa S, Inden Y, Murohara T

    Pacing and clinical electrophysiology : PACE   Vol. 48 ( 11 ) page: 1253 - 1262   2025.11

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    DOI: 10.1111/pace.70060

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  26. Selective Left Bundle Branch Capture Using the Uninterrupted Monitoring Technique: Mid-Term Performance and Safety Profile.

    Kato H, Yanagisawa S, Inden Y

    Journal of cardiovascular electrophysiology   Vol. 36 ( 11 ) page: 2849 - 2851   2025.11

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    DOI: 10.1111/jce.70083

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  27. Characteristics of Effective Antitachycardia Pacing for Ventricular Tachycardia: The Importance of True Septal Lead Position.

    Yanagisawa S, Inden Y, Sato Y, Watanabe R, Miyazawa H, Miyamae K, Iwawaki T, Goto T, Kondo S, Tachi M, Shimojo M, Tsuji Y, Okumura T, Murohara T

    JACC. Asia   Vol. 5 ( 10 ) page: 1329 - 1343   2025.10

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    DOI: 10.1016/j.jacasi.2025.07.005

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  28. Plasma proteomics and heart failure: A new frontier beyond ejection fraction.

    Okumura T, Hiraiwa H, Yanagisawa S, Takefuji M, Murohara T

    International journal of cardiology   Vol. 443   page: 133943   2025.9

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    DOI: 10.1016/j.ijcard.2025.133943

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  29. Evaluation of averaged impedance drop percent as a real-time parameter for safe and effective prolonged radiofrequency ablation using the TactiFlex SE catheter: an ex vivo study.

    Suga K, Yamazaki K, Sakurai T, Ota R, Ota T, Kato H, Murakami H, Kada K, Tsuboi N, Yanagisawa S, Inden Y, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing     2025.8

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    DOI: 10.1007/s10840-025-02112-w

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  30. Benefits of Expert Online Consultations for the Detection of Pulmonary Embolism and Timely Treatment: Enhancing Telemedicine Technology-A Case Report.

    Takenaka M, Yanagisawa S, Yoshida Y, Inden Y, Murohara T

    CJC open   Vol. 7 ( 8 ) page: 1093 - 1096   2025.8

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    DOI: 10.1016/j.cjco.2025.05.014

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  31. Peak frequency drop: a novel intraprocedural parameter predicting acute conduction gaps post-pulmonary vein isolation.

    Mizutani Y, Matsumoto Y, Nishio K, Sakai H, Fujiwara G, Nonokawa D, Makino Y, Suzuki H, Ichimiya H, Uchida Y, Watanabe J, Kanashiro M, Yanagisawa S, Inden Y, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   Vol. 68 ( 5 ) page: 1035 - 1044   2025.8

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    DOI: 10.1007/s10840-025-02019-6

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  32. Reply: Side Lobe Artifacts Mimicking False Micro-Perforations.

    Kato H, Yanagisawa S, Shimizu Y, Inden Y, Murohara T

    JACC. Clinical electrophysiology   Vol. 11 ( 8 ) page: 1885 - 1886   2025.8

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    DOI: 10.1016/j.jacep.2025.04.032

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  33. Reply: Septal Perforation During Left Bundle Branch Pacing: Into the Abyss of the Unknown.

    Kato H, Yanagisawa S, Shimizu Y, Inden Y, Murohara T

    JACC. Clinical electrophysiology   Vol. 11 ( 8 ) page: 1882   2025.8

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    DOI: 10.1016/j.jacep.2025.04.024

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  34. Char Formation During Very High-Power Short-Duration Ablation for Atrial Fibrillation.

    Suga K, Kato H, Yamazaki K, Sakurai T, Ota R, Ota T, Murakami H, Kada K, Tsuboi N, Yanagisawa S, Inden Y, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 36 ( 7 ) page: 1569 - 1578   2025.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jce.16707

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  35. Early Left Ventricular Reverse Remodeling After Catheter Ablation of Atrial Fibrillation is Associated With Lower Recurrence Rates and Improved Prognosis in Patients With Left Ventricular Systolic Dysfunction.

    Miyazawa H, Morishima I, Kanzaki Y, Morita Y, Watanabe N, Furui K, Yoshioka N, Shibata N, Arao Y, Yamauchi R, Iwawaki T, Ohi T, Karasawa H, Yanagisawa S, Inden Y, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 36 ( 7 ) page: 1548 - 1558   2025.7

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    DOI: 10.1111/jce.16706

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  36. Reply to the Editor -Additional value of venous flow pattern for ultrasound-guided venous closure with suture-mediated vascular closure device.

    Tachi M, Tanaka A, Teraoka T, Furuta T, Matsushita E, Hayashi K, Shimojo M, Yanagisawa S, Inden Y, Murohara T

    Heart rhythm   Vol. 22 ( 7 ) page: e259   2025.7

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    DOI: 10.1016/j.hrthm.2024.11.006

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  37. Time-frequency analysis of high-frequency power profile within the QRS complex in patients with ventricular tachycardia using wavelet transform.

    Hiramatsu K, Yanagisawa S, Inden Y, Yamauchi R, Watanabe R, Tsurumi N, Suzuki N, Iwawaki T, Goto T, Kondo S, Tachi M, Shimojo M, Tsuji Y, Murohara T

    Journal of electrocardiology   Vol. 91   page: 154027   2025.7

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    DOI: 10.1016/j.jelectrocard.2025.154027

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  38. Reply: QS Morphology in a Nonfiltered Unipolar Electrogram From a Left Bundle Branch Pacing Lead.

    Kato H, Yanagisawa S, Shimizu Y, Inden Y, Murohara T

    JACC. Clinical electrophysiology   Vol. 11 ( 7 ) page: 1630   2025.7

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    DOI: 10.1016/j.jacep.2025.05.022

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  39. A simple technique for manipulating a pentaspline pulsed field ablation catheter to select right inferior pulmonary vein using vertebral body alignment.

    Mizutani Y, Nonokawa D, Kanashiro M, Yanagisawa S, Inden Y, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   Vol. 68 ( 4 ) page: 731 - 733   2025.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10840-025-01999-9

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  40. Clinical Outcomes and Electrophysiological Characteristics of Partial Perforation After Left Bundle Branch Area Pacing.

    Kato H, Yanagisawa S, Shimizu Y, Ota R, Sakurai T, Suga K, Murakami H, Kada K, Tsuboi N, Inden Y, Murohara T

    JACC. Clinical electrophysiology   Vol. 11 ( 6 ) page: 1279 - 1289   2025.6

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    DOI: 10.1016/j.jacep.2025.01.016

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  41. Blood pressure at hospital admission: a window into the prognoses of patients with atrial fibrillation.

    Okumura T, Yanagisawa S, Murohara T

    Hypertension research : official journal of the Japanese Society of Hypertension   Vol. 48 ( 6 ) page: 1985 - 1987   2025.6

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    DOI: 10.1038/s41440-025-02196-x

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  42. Global myocardial work index predicts response to biventricular pacing in patients with non-left bundle branch block.

    Kondo S, Inden Y, Yanagisawa S, Miyamae K, Miyazawa H, Goto T, Tachi M, Iwawaki T, Yamauchi R, Hiramatsu K, Shimojo M, Tsuji Y, Murohara T

    ESC heart failure   Vol. 12 ( 3 ) page: 2210 - 2224   2025.6

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    DOI: 10.1002/ehf2.15246

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  43. Acute Chest Pain and ST-Segment Changes in a Patient After Permanent His-Bundle Pacing Pacemaker Implantation.

    Yanagisawa S, Inden Y, Tsuji Y, Shibata R, Murohara T

    JACC. Case reports   Vol. 30 ( 8 ) page: 103203   2025.4

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    DOI: 10.1016/j.jaccas.2024.103203

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  44. A novel peak frequency mapping algorithm for the precise localization of accessory pathways in the middle cardiac vein: a case report.

    Fujiwara G, Mizutani Y, Yanagisawa S, Inden Y, Murohara T

    European heart journal. Case reports   Vol. 9 ( 4 ) page: ytaf181   2025.4

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    DOI: 10.1093/ehjcr/ytaf181

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  45. Pace-mapping guided approach on 3-dimensional imaging predicted the origin of ventricular tachycardia in a non-mirrored dextrocardia patient with counter-clockwise rotation of the cardiac apex: Usefulness of aVR lead for estimation.

    Makino Y, Mizutani Y, Kanashiro M, Yanagisawa S, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 11 ( 4 ) page: 287 - 290   2025.4

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    DOI: 10.1016/j.hrcr.2024.12.011

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  46. Transmural left atrial roofline block using rescue cryoballoon ablation after unsuccessful radiofrequency ablation.

    Kato H, Yanagisawa S, Suga K, Murakami H, Inden Y, Murohara T

    Heart rhythm O2   Vol. 6 ( 4 ) page: 546 - 550   2025.4

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    DOI: 10.1016/j.hroo.2025.01.010

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  47. A Practical Scoring System for Estimating Ventricular Arrhythmia Events in Patients with Cardiac Resynchronization Therapy for Primary Prevention.

    Goto T, Inden Y, Yanagisawa S, Tsurumi N, Miyamae K, Miyazawa H, Kondo S, Tachi M, Iwawaki T, Yamauchi R, Hiramatsu K, Shimojo M, Tsuji Y, Murohara T

    International heart journal   Vol. 66 ( 2 ) page: 241 - 251   2025.3

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    DOI: 10.1536/ihj.24-646

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  48. Discontinuation of Oral Anticoagulation After Successful Atrial Fibrillation Ablation.

    Iwawaki T, Yanagisawa S, Inden Y, Hiramatsu K, Yamauchi R, Miyamae K, Miyazawa H, Goto T, Kondo S, Tachi M, Shimojo M, Tsuji Y, Murohara T

    JAMA network open   Vol. 8 ( 3 ) page: e251320   2025.3

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    DOI: 10.1001/jamanetworkopen.2025.1320

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  49. Different time course effect of autonomic nervous modulation after cryoballoon and hotballoon catheter ablations for paroxysmal atrial fibrillation.

    Suzuki N, Inden Y, Yanagisawa S, Shimizu Y, Narita S, Hiramatsu K, Yamauchi R, Watanabe R, Tsurumi N, Shimojo M, Suga K, Tsuji Y, Shibata R, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   Vol. 68 ( 2 ) page: 355 - 369   2025.3

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    DOI: 10.1007/s10840-023-01581-1

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  50. Exploring epicardial arrhythmogenic substrates in long QT syndrome type III overlapping with J-wave syndrome.

    Shimojo M, Inden Y, Yanagisawa S, Tsuji Y, Murohara T

    HeartRhythm case reports   Vol. 11 ( 3 ) page: 256 - 260   2025.3

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    DOI: 10.1016/j.hrcr.2024.12.006

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  51. Early catheter ablation: A promising and effective approach for atrial fibrillation and post-heart failure recovery-Timing matters.

    Yanagisawa S, Inden Y, Murohara T

    International journal of cardiology. Heart & vasculature   Vol. 56   page: 101604   2025.2

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    DOI: 10.1016/j.ijcha.2025.101604

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  52. Editorial to "Pre-procedural imaging guiding ventricular tachycardia ablation in structural heart disease".

    Mizutani Y, Yanagisawa S, Inden Y

    Journal of arrhythmia   Vol. 41 ( 1 ) page: e13211   2025.2

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    DOI: 10.1002/joa3.13211

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  53. Editorial to "Novel mapping techniques for ablation of non-pulmonary vein foci using complex signal identification".

    Mizutani Y, Yanagisawa S, Inden Y

    Journal of arrhythmia   Vol. 41 ( 1 ) page: e70006   2025.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/joa3.70006

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  54. Feasibility of left bundle branch area pacing with left axillary pacemaker implantation in a young female patient with heart failure.

    Kato H, Narita Y, Yanagisawa S, Inden Y, Murohara T

    Journal of arrhythmia   Vol. 41 ( 1 ) page: e70022   2025.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/joa3.70022

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  55. Synthesized V7 QRS Amplitude and Oversensing Episodes in Patients With Subcutaneous Implantable Cardioverter-Defibrillators.

    Okajima T, Ishikawa S, Yanagisawa S, Okamoto T, Uemura Y, Takemoto K, Inden Y, Murohara T, Watarai M

    Pacing and clinical electrophysiology : PACE   Vol. 47 ( 12 ) page: 1565 - 1573   2024.12

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    DOI: 10.1111/pace.15086

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  56. An abrupt loss of capture during permanent His-bundle pacing: Assessment of mechanism underlying late capture threshold rise.

    Kato H, Yanagisawa S, Ota R, Inden Y, Murohara T

    Journal of arrhythmia   Vol. 40 ( 6 ) page: 1525 - 1528   2024.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/joa3.13165

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  57. Editorial to "Performance of the novel ANTWERP score in predicting heart function improvement after atrial fibrillation ablation in Asian patients with heart failure".

    Yanagisawa S, Inden Y, Murohara T

    Journal of arrhythmia   Vol. 40 ( 6 ) page: 1370 - 1371   2024.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/joa3.13173

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  58. Editorial to "investigating the role of electroanatomical mapping in single-shot pulsed field catheter ablation".

    Mizutani Y, Yanagisawa S, Inden Y

    Journal of arrhythmia   Vol. 40 ( 6 ) page: 1379 - 1380   2024.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/joa3.13184

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  59. Do not stop effective atrial-based antitachycardia pacing: Insights into episode duration and success rate for termination.

    Yanagisawa S, Sato Y, Shimizu A, Narita Y, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 10 ( 12 ) page: 867 - 871   2024.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.hrcr.2024.08.016

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  60. Differentiation between epicardial and endocardial conduction gaps for left atrial posterior wall isolation using peak frequency annotation algorithm.

    Suga K, Kato H, Murakami H, Yanagisawa S, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 10 ( 12 ) page: 912 - 916   2024.12

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    DOI: 10.1016/j.hrcr.2024.08.028

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  61. Identification of regions maintaining atrial fibrillation through cycle length and cycle length gradient mapping.

    Shimojo M, Inden Y, Yanagisawa S, Yamauchi R, Hiramatsu K, Iwawaki T, Tachi M, Kondo S, Goto T, Tsuji Y, Murohara T

    Journal of arrhythmia   Vol. 40 ( 6 ) page: 1389 - 1399   2024.12

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    DOI: 10.1002/joa3.13151

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  62. Optimal ablation settings of TactiFlex SE laser-cut irrigated-tip catheter: comparison with ThermoCool SmartTouch SurroundFlow porous irrigated-tip catheter.

    Suga K, Kato H, Akita S, Sakurai T, Ota R, Okada T, Murakami H, Kada K, Tsuboi N, Yanagisawa S, Inden Y, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   Vol. 67 ( 8 ) page: 1755 - 1769   2024.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10840-024-01797-9

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  63. Early Cryoablation After First Diagnosis of Atrial Fibrillation Reduces Arrhythmia Recurrence in Heart Failure Patients.

    Ando M, Yanagisawa S, Suzuki H, Yoshida Y, Kanzaki Y, Morishima I, Ishikawa S, Kamikubo Y, Okumura S, Kato H, Mizutani Y, Murase Y, Nakasuka K, Warita S, Sekimoto S, Takemoto Y, Takasugi N, Ohguchi S, Senga M, Yokoi K, Watanabe R, Ogura Y, Shibata R, Inden Y, Murohara T

    JACC. Asia   Vol. 4 ( 11 ) page: 857 - 871   2024.11

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    DOI: 10.1016/j.jacasi.2024.08.005

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  64. Feasibility and efficacy of real-time ultrasound-guided venous closure with suture-mediated vascular closure device.

    Tachi M, Tanaka A, Teraoka T, Furuta T, Matsushita E, Hayashi K, Shimojo M, Yanagisawa S, Inden Y, Murohara T

    Heart rhythm   Vol. 21 ( 10 ) page: 2028 - 2036   2024.10

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    DOI: 10.1016/j.hrthm.2024.04.041

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  65. A Novel Liver Fibrosis Marker FIB-5 Index Predicted Response to Cardiac Resynchronization Therapy and Prognostic Outcomes in Patients With Heart Failure. Reviewed

    Iwawaki T, Inden Y, Yanagisawa S, Goto T, Kondo S, Tachi M, Hiramatsu K, Yamauchi R, Shimojo M, Tsuji Y, Murohara T

    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc   Vol. 29 ( 5 ) page: e70004   2024.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/anec.70004

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  66. Reversible complete left bundle branch block and a wide QRS complex following administration of sodium-glucose cotransporter-2 inhibitor and volume reduction in a patient with systolic heart failure: a case report.

    Takenaka M, Yanagisawa S, Yoshida Y, Inden Y, Murohara T

    European heart journal. Case reports   Vol. 8 ( 9 ) page: ytae512   2024.9

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    DOI: 10.1093/ehjcr/ytae512

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  67. Long-Term Outcomes in Patients With Relatively High His-Bundle Capture Threshold After Permanent His-Bundle Pacing - A Multicenter Clinical Study. Reviewed Open Access

    Watanabe R, Kato H, Yanagisawa S, Sakurai T, Ota R, Murakami H, Kada K, Tsuboi N, Inden Y, Shibata R, Murohara T

    Circulation reports   Vol. 6 ( 8 ) page: 294 - 302   2024.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circrep.CR-24-0035

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  68. Elevated liver fibrosis-4 index predicts recurrence after catheter ablation for atrial fibrillation in patients with heart failure.

    Iwawaki T, Morishima I, Kanzaki Y, Morita Y, Watanabe N, Yoshioka N, Shibata N, Miyazawa H, Shimojo K, Yanagisawa S, Inden Y, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   Vol. 67 ( 5 ) page: 1093 - 1108   2024.8

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    DOI: 10.1007/s10840-023-01661-2

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  69. Editorial to "Notched P-wave on digital electrocardiogram predicts the recurrence of atrial fibrillation in patients who have undergone catheter ablation".

    Yanagisawa S, Inden Y, Murohara T

    Journal of arrhythmia   Vol. 40 ( 4 ) page: 790 - 791   2024.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/joa3.13067

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  70. Evaluation of microembolic signals on carotid ultrasound during pulmonary vein isolation with high-power short-duration and cryoballoon ablations: When and where do bubble and solid emboli arise?

    Mizutani Y, Yanagisawa S, Ichikawa M, Nishio K, Sakai H, Nonokawa D, Makino Y, Suzuki H, Ichimiya H, Uchida Y, Watanabe J, Kanashiro M, Inden Y, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 35 ( 8 ) page: 1589 - 1600   2024.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jce.16337

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  71. Mid-term outcomes of delivery catheter-based and stylet-based right ventricular septal pacing: Follow-up results from a multicenter, prospective, randomized study. Reviewed

    Tsurumi N, Naruse Y, Kurebayashi N, Morikawa S, Sano M, Shiozawa T, Takano S, Ogano M, Kimura K, Miyajima K, Sugiura R, Henmi R, Muto M, Hosoya N, Hasebe H, Mizukami A, Iguchi K, Atsumi A, Odagiri K, Yanagisawa S, Inden Y, Murohara T, Maekawa Y

    Journal of arrhythmia   Vol. 40 ( 3 ) page: 605 - 613   2024.6

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    DOI: 10.1002/joa3.13034

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  72. Coagulation Profile After Catheter Ablation for Ventricular Tachycardia in Antiplatelet and Anticoagulant Regimens. Reviewed

    Yanagisawa S, Inden Y, Iwawaki T, Tachi M, Hiramatsu K, Yamauchi R, Shimojo M, Tsuji Y, Shibata R, Murohara T

    JACC. Clinical electrophysiology   Vol. 10 ( 5 ) page: 976 - 978   2024.5

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jacep.2024.02.013

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  73. Comparison of novel intrinsic versus conventional antitachycardia pacing for ventricular tachycardia among implantable cardioverter-defibrillator recipients.

    Yanagisawa S, Inden Y, Sato Y, Watanabe R, Goto T, Kondo S, Tachi M, Iwawaki T, Yamauchi R, Hiramatsu K, Shimojo M, Tsuji Y, Shibata R, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 35 ( 4 ) page: 821 - 831   2024.4

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    DOI: 10.1111/jce.16232

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  74. Development of a rapid and comprehensive genomic profiling test supporting diagnosis and research for gliomas.

    Nakashima T, Yamamoto R, Ohno M, Sugino H, Takahashi M, Funakoshi Y, Nambu S, Uneda A, Yanagisawa S, Uzuka T, Arakawa Y, Hanaya R, Ishida J, Yoshimoto K, Saito R, Narita Y, Suzuki H

    Brain tumor pathology   Vol. 41 ( 2 ) page: 50 - 60   2024.4

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    DOI: 10.1007/s10014-023-00476-3

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  75. Distributions and number of drivers on real-time phase mapping associated with successful atrial fibrillation termination during catheter ablation for non-paroxysmal atrial fibrillation. Reviewed

    Riku S, Inden Y, Yanagisawa S, Fujii A, Tomomatsu T, Nakagomi T, Shimojo M, Okajima T, Furui K, Suga K, Suzuki S, Shibata R, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   Vol. 67 ( 2 ) page: 303 - 317   2024.3

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    DOI: 10.1007/s10840-023-01588-8

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  76. Reply: Methodological and Mechanistic Considerations in Local Repolarization Mapping.

    Yanagisawa S, Inden Y, Tsuji Y, Shibata R, Murohara T

    JACC. Clinical electrophysiology   Vol. 10 ( 2 ) page: 378   2024.2

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    DOI: 10.1016/j.jacep.2024.01.009

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  77. Editorial to "pseudo-slow-fast atrioventricular nodal reentrant tachycardia: Is the fast pathway a criminal or innocent bystander?".

    Mizutani Y, Yanagisawa S, Inden Y

    Journal of arrhythmia   Vol. 40 ( 1 ) page: 146 - 147   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/joa3.12978

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  78. Usefulness of omnipolar technology near field for accessory pathway ablation through the coronary sinus.

    Mizutani Y, Yanagisawa S, Matsumoto Y, Kanashiro M, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 10 ( 1 ) page: 92 - 95   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.hrcr.2023.10.030

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  79. Clinical outcomes and predictors of delayed echocardiographic response to cardiac resynchronization therapy.

    Tsurumi N, Inden Y, Yanagisawa S, Hiramatsu K, Yamauchi R, Watanabe R, Suzuki N, Shimojo M, Suga K, Tsuji Y, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 35 ( 1 ) page: 97 - 110   2024.1

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    DOI: 10.1111/jce.16125

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  80. Mechanisms of torsades de pointes: an update. Reviewed

    Tsuji Y, Yamazaki M, Shimojo M, Yanagisawa S, Inden Y, Murohara T

    Frontiers in cardiovascular medicine   Vol. 11   page: 1363848   2024

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    DOI: 10.3389/fcvm.2024.1363848

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  81. Association Between Catheter Ablation for Nonparoxysmal Atrial Fibrillation and Functional Mitral Regurgitation in Patients With Heart Failure With Preserved Ejection Fraction.

    Yamauchi R, Morishima I, Okumura K, Kanzaki Y, Morita Y, Watanabe N, Furui K, Yoshioka N, Shibata N, Miyazawa H, Shimojo K, Imaoka T, Sakamoto G, Goto H, Ohi T, Yanagisawa S, Inden Y, Murohara T

    The American journal of cardiology   Vol. 207   page: 192 - 201   2023.11

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    DOI: 10.1016/j.amjcard.2023.08.154

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  82. Visualization of Repolarization Heterogeneity in Brugada Syndrome: A Quantitative Analysis of Unipolar Electrogram T-Wave. Reviewed Open Access

    Yanagisawa S, Inden Y, Goto T, Kondo S, Tachi M, Iwawaki T, Hiramatsu K, Yamauchi R, Shimojo M, Tsuji Y, Shibata R, Murohara T

    JACC. Clinical electrophysiology   Vol. 9 ( 11 ) page: 2401 - 2411   2023.11

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jacep.2023.08.010

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  83. Worldwide survey on implantation of and outcomes for conduction system pacing with His bundle and left bundle branch area pacing leads. Reviewed Open Access

    Perino AC, Wang PJ, Lloyd M, Zanon F, Fujiu K, Osman F, Briongos-Figuero S, Sato T, Aksu T, Jastrzebski M, Sideris S, Rao P, Boczar K, Yuan-Ning X, Wu M, Namboodiri N, Garcia R, Kataria V, De Pooter J, Przibille O, Gehi AK, Cano O, Katsouras G, Cai B, Astheimer K, Tanawuttiwat T, Datino T, Rizkallah J, Alasti M, Feld G, Barrio-Lopez MT, Gilmore M, Conti S, Yanagisawa S, Indik JH, Zou J, Saha SA, Rodriguez-Munoz D, Chang KC, Lebedev DS, Leal MA, Haeberlin A, Forno ARJD, Orlov M, Frutos M, Cabanas-Grandio P, Lyne J, Leyva F, Tolosana JM, Ollitrault P, Vergara P, Balla C, Devabhaktuni SR, Forleo G, Letsas KP, Verma A, Moak JP, Shelke AB, Curila K, Cronin EM, Futyma P, Wan EY, Lazzerini PE, Bisbal F, Casella M, Turitto G, Rosenthal L, Bunch TJ, Baszko A, Clementy N, Cha YM, Chen HC, Galand V, Schaller R, Jarman JWE, Harada M, Wei Y, Kusano K, Schmidt C, Hurtado MAA, Naksuk N, Hoshiyama T, Kancharla K, Iida Y, Mizobuchi M, Morin DP, Cay S, Paglino G, Dahme T, Agarwal S, Vijayaraman P, Sharma PS

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   Vol. 66 ( 7 ) page: 1589 - 1600   2023.10

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    DOI: 10.1007/s10840-022-01417-4

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  84. Subclinical persistent atrial fibrillation in left atrium behind the ectopic atrial rhythm on electrocardiogram.

    Mizutani Y, Yanagisawa S, Makino Y, Kanashiro M, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 9 ( 9 ) page: 685 - 688   2023.9

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    DOI: 10.1016/j.hrcr.2023.07.005

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  85. Evaluation of the direction and extent of ice formation during cryoballoon ablation: an experimental study.

    Mizutani Y, Yanagisawa S, Fujiwara G, Kasai Y, Tajima A, Makino Y, Suzuki H, Hiramatsu T, Ichimiya H, Uchida Y, Watanabe J, Kanashiro M, Inden Y, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   Vol. 66 ( 4 ) page: 981 - 989   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Interventional Cardiac Electrophysiology  

    Background: The distal hemisphere of a balloon is generally cooled during cryoapplication. However, a wide ablation area can be acquired after cryoballoon ablation. This study aimed to evaluate the extent of ice formation on two types of balloon surfaces through experimental and simulation studies. Methods: A standard cryoballoon (SCB; Arctic Front Advance Pro, Medtronic) and novel cryoballoon (NCB; POLARx, Boston Scientific) were frozen for 240 s in 36 °C normal saline solution to observe ice formation on the balloon surface. Pieces of porcine tissue were placed between the upper and lower sides of the balloon, and the balloon was frozen in the horizontal direction for 240 s in 20 attempts (10 for SCB and NCB each). The measured areas of ice formation were evaluated and compared between the upper and lower sides of each balloon. Results: Ice formation was greater on the lower side of the balloon than on the upper side. A larger area of ice formation in the tissue slab was observed on the lower side than on the upper side in both balloons, and the ice formation extended to the proximal hemisphere on the lower side of the balloon. The ice formation area in the NCB was significantly larger than that in SCB. Conclusions: Ice formation was significantly greater on the lower side of the cryoballoon than on the upper side and extended to the proximal hemisphere of the balloon, which might facilitate the acquisition of a wide ablation area on the left atrial posterior wall after cryoballoon ablation. Graphical Abstract: Different ice formation after cryoballoon ablation Greater ice formation on the lower side of cryoballoon and an extensive ice formation in the proximal hemisphere, especially in novel cryoballoon. [Figure not available: see fulltext.]

    DOI: 10.1007/s10840-022-01411-w

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  86. Transmural lesion formation after left atrial roof cryoballoon ablation: Insight from simultaneous high-density epicardial mapping. Open Access

    Kato H, Yanagisawa S, Sakurai T, Murakami H, Inden Y, Murohara T

    Heart rhythm O2   Vol. 4 ( 5 ) page: 329 - 332   2023.5

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    DOI: 10.1016/j.hroo.2023.02.004

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  87. Successful catheter ablation for a dominant atrial fibrillation driver manifested after box isolation using a novel mapping system in a patient with persistent atrial fibrillation.

    Tachi M, Teraoka T, Hayashi K, Yanagisawa S, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 9 ( 5 ) page: 319 - 323   2023.5

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    DOI: 10.1016/j.hrcr.2023.02.010

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  88. Catheter ablation for atrial fibrillation in heart failure: Getting closer to the full picture in the whole population.

    Yanagisawa S, Inden Y, Murohara T

    International journal of cardiology   Vol. 376   page: 81 - 82   2023.4

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    DOI: 10.1016/j.ijcard.2023.02.010

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  89. A rare case of delayed complete lead dislodgement after deep septal pacing: A hidden risk of the specific procedure.

    Watanabe R, Inden Y, Yanagisawa S, Narita Y, Hiramatsu K, Yamauchi R, Tsurumi N, Suzuki N, Shimojo M, Suga K, Tsuji Y, Murohara T

    Pacing and clinical electrophysiology : PACE   Vol. 46 ( 4 ) page: 341 - 345   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pace.14688

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  90. A novel practical algorithm using machine learning to differentiate outflow tract ventricular arrhythmia origins. Open Access

    Shimojo M, Inden Y, Yanagisawa S, Suzuki N, Tsurumi N, Watanabe R, Nakagomi T, Okajima T, Suga K, Tsuji Y, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 34 ( 3 ) page: 627 - 637   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jce.15823

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  91. Efficacy and feasibility of cryoballoon ablation for atrial fibrillation in patients with heart failure: A large-scale multicenter study.

    Yanagisawa S, Suzuki H, Kanzaki Y, Ishikawa S, Kamikubo Y, Okumura S, Kato H, Mizutani Y, Murase Y, Nakasuka K, Warita S, Sekimoto S, Takemoto Y, Takasugi N, Ohguchi S, Senga M, Yokoi K, Shibata R, Inden Y, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 33 ( 12 ) page: 2447 - 2464   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Cardiovascular Electrophysiology  

    Introduction: Data are limited regarding outcomes of cryoballoon ablation for atrial fibrillation (AF) in patients with heart failure (HF). This large-scale multicenter study aimed to evaluate the prognosis of patients with HF after cryoballoon ablation for AF. Methods: Among 3655 patients undergoing cryoballoon ablation at 17 institutions, 549 patients (15%) (391 with paroxysmal AF and 158 with persistent AF) diagnosed with HF preoperatively were analyzed. Clinical endpoints were recurrence, mortality, and HF hospitalization after ablation. Results: Most patients had a preserved left ventricular ejection fraction (LVEF) ≥ 50%. During a mean follow-up period of 25.7 months, recurrence, all-cause death, and HF hospitalization occurred in 29%, 4.0%, and 4.8%, respectively. Cardiac function on echocardiography and B-type natriuretic peptide (BNP) levels significantly improved postoperatively, and the effect was more pronounced in the nonrecurrence group. Major complications occurred in 33 patients (6.0%), but most complications were phrenic nerve palsy (3.6%). Although death and HF hospitalization occurred more frequently in patients with LVEF ≤ 40% (n = 73) and New York Heart Association (NYHA) class III–IV (n = 19) than other subgroups, the BNP levels, and LVEF significantly improved after ablation in all LVEF and NYHA class subgroups. High BNP levels, NHYA class, CHADS2 score, and structural heart disease, but not postablation recurrence, independently predicted death, and HF hospitalization on multivariate analysis. The patients with tachycardia-induced cardiomyopathy had better recovery of BNP levels and LVEF after ablation than those with structural heart disease. Conclusions: Cryoballoon ablation for AF in HF patients is feasible and leads to significantly improved cardiac function.

    DOI: 10.1111/jce.15691

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  92. A case of successful catheter ablation of blocked atrial bigeminy and bradycardia with the recovery of normal sinus rhythm and myocardial reverse remodeling. Open Access

    Sugiyama T, Mizutani Y, Yanagisawa S, Kanashiro M, Inden Y, Murohara T

    Clinical case reports   Vol. 10 ( 12 ) page: e6791   2022.12

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    DOI: 10.1002/ccr3.6791

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  93. Regional left atrial conduction velocity in the anterior wall is associated with clinical recurrence of atrial fibrillation after catheter ablation: efficacy in combination with the ipsilateral low voltage area. Reviewed Open Access

    Ohguchi S, Inden Y, Yanagisawa S, Fujita R, Yasuda K, Katagiri K, Oguri M, Murohara T

    BMC cardiovascular disorders   Vol. 22 ( 1 ) page: 457   2022.11

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    Background: Left atrial (LA) conduction velocity (CV) is an electrical remodeling parameter of atrial fibrillation (AF) substrate. However, the pathophysiological substrate of LA-CV and its impact on outcomes after catheter ablation for AF have not been well evaluated. Methods: We retrospectively evaluated 119 patients with AF who underwent catheter ablation and electroanatomical mapping during sinus rhythm. To measure regional LA-CV, we took triplet sites (A, B, and C) on the activation map and calculated the magnitude of the matched orthogonal projection vector between vector-AB and vector-AC, indicating two-dimensional CV. The median of the LA-CVs from four triad sites in both the anterior and posterior walls was set as the ‘model LA-CV’. We evaluated the impact of the model LA-CV on recurrence after ablation and relationship between the model LA-CV and LA-low voltage area (LVA) of < 0.5 mV. Results: During the 12-month follow-up, 29 patients experienced recurrence. The LA-CV model was significantly correlated with ipsilateral LVA. The lower anterior model LA-CV was significantly associated with recurrence, with the cut-off value of 0.80 m/s having a sensitivity of 72% and specificity of 67%. Multivariable analysis revealed that the anterior model LA-CV (hazard ratio, 0.09; 95% confidence interval, 0.01–0.94; p = 0.043) and anterior LA-LVA (hazard ratio, 1.06; 95% confidence interval, 1.00–1.11; p = 0.033) were independently associated with AF recurrence. The anterior LA-LVA was mildly correlated with the anterior model LA-CV (r = -0.358; p < 0.001), and patients with both lower LA-CV and greater anterior LA-LVA based on each cut-off value had the worst prognosis. However, decreased LA-CV was more likely to be affected by the distribution pattern of the LVA rather than the total size of the LVA. Conclusion: Decreased anterior LA-CV was a significant predictor of AF recurrence and was a useful electrical parameter in addition to LA-LVA for estimating AF arrhythmogenicity.

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  94. Septal coronary artery fistula after left bundle branch area pacing assessed by multi-imaging modalities and shunt volume quantification.

    Kato H, Yanagisawa S, Ota R, Murakami H, Kada K, Tsuboi N, Inden Y, Murohara T

    Pacing and clinical electrophysiology : PACE   Vol. 45 ( 11 ) page: 1299 - 1302   2022.11

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  95. Impact of synchronized left ventricular pacing rate on risk for ventricular tachyarrhythmias after cardiac resynchronization therapy in patients with heart failure. Reviewed

    Okajima T, Inden Y, Yanagisawa S, Suga K, Shimojo M, Nakagomi T, Tsurumi N, Watanabe R, Suzuki N, Shibata R, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   Vol. 65 ( 1 ) page: 239 - 249   2022.10

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    Background: The adaptive cardiac resynchronization therapy (aCRT) algorithm automatically produces synchronized left ventricular pacing (sLVP) with intrinsic atrioventricular conduction to improve clinical outcomes. However, relationship between sLVP percentage and risk for ventricular tachyarrhythmia (VT/VF) remains unclear. This study aimed to evaluate the clinical impact of sLVP rate on VT/VF occurrence. Methods: In total, 1,419 device interrogation data from 42 consecutive patients who underwent new aCRT device implantation were retrospectively analyzed. The primary endpoint was the first time VT/VF episode after aCRT device implantation. Results: During a median follow-up of 34 months, 15 patients had VT/VF episodes. Patients were divided into a high sLVP (the average sLVP percentage of ≥ 51.5%, n = 27) or low sLVP group (< 51.5%, n = 15). The high sLVP group had a significantly lower VT/VF incidence (22% vs. 60%; p = 0.014) and an independent predictor for VT/VF occurrence on multivariate analysis (hazard ratio 0.21; p = 0.007). LV ejection fraction improvements after 6 months (12.3 ± 8.7% vs. 2.8 ± 10.3%; p = 0.004) and 12 months (13.8 ± 9.3% vs. 6.2 ± 11.1%; p = 0.030) were significantly greater in the high sLVP group than in the low sLVP group. Age, PR interval, and left atrial diameter were significantly associated with the sLVP rate after aCRT. Conclusions: Patients with high sLVP percentage after aCRT had lower long-term risk of VT/VF incidence with a favorable response to CRT. A synchronized pacing algorithm using intrinsic conduction may prevent malignant arrhythmias, as well as recover cardiac functions.

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  96. Depolarization and repolarization dynamics after His-bundle pacing: Comparison with right ventricular pacing and native ventricular conduction. Reviewed Open Access

    Yanagisawa S, Inden Y, Watanabe R, Tsurumi N, Suzuki N, Nakagomi T, Shimojo M, Okajima T, Riku S, Furui K, Suga K, Shibata R, Murohara T

    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc   Vol. 27 ( 5 ) page: e12991   2022.9

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    Background: The current study aimed to evaluate changes in electrical depolarization and repolarization parameters after His-bundle pacing (HBP) compared with right ventricular pacing (RVP) and its association with ventricular arrhythmia (VA). Methods: Forty-one patients (13 with HBP, 14 with RVP, and 14 controls [AAI mode]) were evaluated. After continuous pacing algorithm, QRS duration, QT interval, QTc, JT interval, T-peak to T-end (Tpe), and Tpe/QT ratio were measured on electrocardiography at baseline and 1 week, 1 month, and 6 months postoperatively. We investigated VA occurrence and adverse events after implantation. Results: At 6 months, QRS duration was significantly shorter in the HBP (121.6 ± 15.6 ms) than in the RVP (150.1 ± 14.9 ms) group. The QT intervals were lower in the HBP (424.0 ± 40.9 ms) and control (405.9 ± 23.0 ms) groups than in the RVP (453.0 ± 40.2 ms) group. The Tpe and Tpe/QT ratios at 6 months differed significantly between the HBP and RVP groups (Tpe, 69.8 ± 19.7 ms vs 87.4 ± 11.9 ms and Tpe/QT, 0.16 ± 0.03 vs 0.19 ± 0.02, respectively). The Tpe and Tpe/QT ratios were similarly shortened in the HBP and control groups. VA occurred less frequently in the HBP (15%) and control (7.1%) groups than in the RVP (50%) group (p = 0.020). The non-RVP group showed significantly lower rates of VA and major adverse events than the RVP group. Patients with VA demonstrated significantly longer QRS duration, QT interval, Tpe, and Tpe/QT at 6 months than those without VA. Conclusion: HBP showed better depolarization and repolarization stability than RVP.

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  97. Characteristics of successful reactive atrial-based antitachycardia pacing in patients with cardiac implantable electronic devices: History of catheter ablation of atrial fibrillation as a predictor of high treatment efficacy.

    Nakagomi T, Inden Y, Yanagisawa S, Suzuki N, Tsurumi N, Watanabe R, Shimojo M, Okajima T, Suga K, Shibata R, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 33 ( 7 ) page: 1515 - 1528   2022.7

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    Introduction: Reactive atrial-based antitachycardia pacing (rATP) in patients with cardiac implantable electronic devices (CIEDs) suppresses the progression of atrial fibrillation (AF) to the persistent form. However, the clinical factors associated with successful reactive atrial-based antitachycardia pacing (rATP) treatment are unknown. This study aimed to examine the predictors of high rATP efficacy in patients with CIEDs. Methods: The data of 101,325 rATP-treated atrial tachyarrhythmia (AT/AF) episodes in 51 patients, obtained through remote monitoring and device interrogation, were analyzed. The study population was divided into the high and low efficacy groups based on the overall median success rate of rATP. Clinical characteristics were compared between the two groups. Results: During a follow-up period of 28.6 ± 8.6 months, the median success rate was 43.7% (31.5%–64.9%). The prevalence of a history of catheter ablation of AF was significantly higher in the high efficacy group than in the low efficacy group (73.0% vs. 44.0%, p =.048) and was the only independent predictor of high rATP efficacy (odds ratio, 3.45; p =.038). The rATP success rate in patients with (n = 30) and without (n = 21) a history of catheter ablation was 53.9% (40.0%–67.5%) and 36.4% (22.2%–47.7%), respectively (p =.012). The effect of rATP after ablation was more pronounced in patients with long cycle length episodes (≥75% of AT/AF sequences having a cycle length of 200–449 ms) (67.3% [46.0%–73.6%] vs. 30.6% [18.1%–60.3%], p =.027). The high efficacy group had a significantly lower incidence of AT/AF lasting ≥1, ≥7, and ≥30 days than the low efficacy group. Conclusion: rATP combined with catheter ablation therapy is effective in suppressing AT/AF.

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  98. Coagulation Response and Prothrombotic Effect of Uninterrupted Oral Anticoagulant Administration After Catheter Ablation for VT. Reviewed

    Yanagisawa S, Inden Y, Riku S, Furui K, Suga K, Nakagomi T, Shimojo M, Okajima T, Watanabe R, Tsurumi N, Suzuki N, Shibata R, Murohara T

    JACC. Clinical electrophysiology   Vol. 8 ( 6 ) page: 735 - 748   2022.6

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    Background: Catheter ablation for ventricular tachycardia (VT) is associated with perioperative thromboembolic risk. However, the strategy for postprocedural management remains unknown. Objectives: The aim of this study was to evaluate the prothrombotic response after VT ablation in various coagulation biomarkers in patients with and without the administration of oral anticoagulation (OAC). Methods: Data from 112 patients (58 with uninterrupted OAC and 54 without) with structural heart disease who underwent endocardial VT ablation were retrospectively analyzed. We also included 41 patients who underwent ablation for premature ventricular contraction from the right ventricle and 13 patients who underwent electrophysiology study (the control group). Blood samples of coagulation markers were collected before and 3 days after the procedure in all patients. Results: The percentage of D-dimer levels ≤1.0 μg/mL at baseline was lower in the VT ablation groups (76% and 50% in the OAC and non-OAC groups, respectively) than in the other groups (100%). After 3 days, the percentage remained at 67% in the OAC group; however, the non-OAC VT group demonstrated a remarkable decrease of 20%. Similarly, fibrin monomer complex, thrombin antithrombin, and prothrombin fragment 1+2 levels were well suppressed in the control, premature ventricular contraction, and OAC groups. However, the non-OAC group demonstrated increased coagulation markers both before and after 3 days. Multivariate analysis demonstrated that OAC administration and normal coagulation markers at baseline were independent predictors of stable coagulation status after ablation. Conclusions: The coagulation cascade was significantly activated in patients undergoing VT ablation. Uninterrupted OAC administration suppressed the coagulation response, which might be associated with a reduction in perioperative prothrombotic risk.

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  99. Cryoballoon ablation for atrial fibrillation without the use of a contrast medium: a combination of the intracardiac echocardiography and pressure wave monitoring guided approach.

    Makino Y, Mizutani Y, Yamashita D, Yonekawa J, Satake A, Kurobe M, Hiramatsu T, Ichimiya H, Uchida Y, Watanabe J, Kanashiro M, Ichimiya S, Yanagisawa S, Inden Y, Murohara T

    Heart and vessels   Vol. 37 ( 5 ) page: 765 - 774   2022.5

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  100. Short coupling interval with high burden of atrial ectopy predicts recurrence after atrial fibrillation ablation.

    Okajima T, Inden Y, Yanagisawa S, Imai H, Murase Y, Ogawa Y, Kawaguchi K, Murohara T

    Heart and vessels   Vol. 37 ( 5 ) page: 775 - 787   2022.5

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    DOI: 10.1007/s00380-021-01966-0

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  101. Identification of high priority focal activations in persistent atrial fibrillation using a novel mapping strategy.

    Shimojo M, Inden Y, Yanagisawa S, Riku S, Suga K, Furui K, Nakagomi T, Okajima T, Shibata R, Murohara T

    Heart and vessels   Vol. 37 ( 5 ) page: 840 - 853   2022.5

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  102. Long P-wave duration immediately after pulmonary vein isolation on radiofrequency catheter ablation for atrial fibrillation predicts clinical recurrence: correlation with atrial remodeling in persistent atrial fibrillation.

    Ohguchi S, Inden Y, Yanagisawa S, Shigematsu T, Yasuda K, Katagiri K, Oguri M, Murohara T

    Heart and vessels   Vol. 37 ( 3 ) page: 476 - 488   2022.3

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    © 2021, Springer Japan KK, part of Springer Nature. P-wave morphology reflects atrial remodeling and indicates prognosis after radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). The impact of p-wave morphology after excluding the effect of pulmonary vein (PV) substrate on outcomes is unknown. We evaluated the p-wave morphology on electrocardiography immediately after PV isolation for clinical outcomes. Eighty-four consecutive patients (47 with paroxysmal AF and 37 with persistent AF) who underwent RFCA were included. P-wave duration (PWD) and amplitude in all leads were examined during sinus rhythm immediately after PV isolation. We evaluated the relationship between electrocardiogram parameters and AF recurrence, according to the type of AF and following ablation, and the correlation with left atrial (LA) volume, low voltage ratio, and fixed conduction time. During 12 months of follow-up, 20 patients experienced recurrence. The cut-off value of PWD > 120 ms in lead I showed a sensitivity of 75% and specificity of 69% for predicting recurrence. PWD was significantly correlated with LA volume, low voltage, and conduction velocity. Significantly higher recurrence rates were observed in patients with PWD > 120 ms than in those with PWD ≤ 120 ms (p < 0.001), and the difference was more pronounced in patients with persistent AF. Multivariate analysis demonstrated that PWD > 120 ms was independently associated with recurrence in the total population (hazard ratio 2.00; 95% confidence interval 1.27–3.22; p = 0.003) and in patients with persistent AF. In conclusion, long PWD after PV isolation predicts AF recurrence, which might be associated with the extent of the LA substrate in persistent AF.

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  103. Impact of Preoperative Nutritional Status on the Outcome of Catheter Ablation for Atrial Fibrillation. Open Access

    Furui K, Morishima I, Morita Y, Kanzaki Y, Takagi K, Nagai H, Watanabe N, Yoshioka N, Yamauchi R, Miyazawa H, Yanagisawa S, Inden Y, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 86 ( 2 ) page: 268 - 276   2022.1

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  104. Comparison of the empirical linear ablation and low voltage area-guided ablation in addition to pulmonary vein isolation in patients with persistent atrial fibrillation: a propensity score-matched analysis. Reviewed Open Access

    Suzuki N, Kaneko S, Fujita M, Shinoda M, Kubota R, Ohashi T, Tatami Y, Suzuki J, Hori H, Adachi K, Ito R, Shirai Y, Yanagisawa S, Inden Y, Murohara T

    BMC cardiovascular disorders   Vol. 22 ( 1 ) page: 13   2022.1

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    Background: The efficacy of pulmonary vein isolation (PVI) alone is not guaranteed for persistent atrial fibrillation (PeAF), and it is unclear which type of ablation approach should be applied in addition to PVI. This study aimed to compare outcomes and prognosis between empirical linear ablation and low-voltage area (LVA) ablation after PVI for PeAF. Methods: We enrolled 128 patients with PeAF who were assigned to the linear ablation group (n = 64) and the LVA ablation group (n = 64) using a propensity score-matched model. After PVI and cardioversion, the patients underwent either empirical linear ablation or LVA ablation during sinus rhythm. All patients in the linear ablation group underwent both roof line and mitral valve isthmus (MVI) ablations. An electrical-guided ablation targeting LVA (< 0.5 mV) was performed in the LVA group. When there was no LVA in the LVA group, only PVI was applied. We compared the procedural outcomes and recurrence after ablation between the two groups. Results: The baseline characteristics were well-balanced between the two groups. Fifty patients had LVA (22 and 28 patients in the linear and LVA groups). The roof and MVI lines were completed in 100% and 96.9% of the patients. During the mean follow-up of 279.5 ± 161.3 days, the LVA group had significantly lower recurrence than the linear group (15 patients [23%] vs. 29 patients [45%], p = 0.014). Thirty-five patients were prescribed antiarrhythmic drugs during the follow-up period (linear group, n = 17; LVA group, n = 18); amiodarone and bepridil were administered to most of the patients (15 and 17 patients, respectively). The difference in the prognosis was relevant among the patients with LVA, while this trend was not observed in those without LVA. The LVA ablation group demonstrated significantly lower radiofrequency energy and shorter procedural time compared to the linear ablation group. The recurrence of atrial flutter was more likely to occur in the linear group than in the LVA group (14 [22%] vs. 6 [9.4%], p = 0.052). Conclusion: The electrophysiological-guided LVA ablation is more effective than empirical linear ablation in PeAF patients with LVA. Unnecessary empirical linear ablation might have a risk of iatrogenic gap and atrial flutter recurrence.

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  105. Efficacy of His Bundle Pacing on LV Relaxation and Clinical Improvement in HF and LBBB. Reviewed

    Kato H, Yanagisawa S, Sakurai T, Mizuno C, Ota R, Watanabe R, Suga K, Okada T, Murakami H, Kada K, Inden Y, Tsuboi N, Murohara T

    JACC. Clinical electrophysiology   Vol. 8 ( 1 ) page: 59 - 69   2022.1

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    Objectives: This study aimed to compare acute hemodynamic improvements and responses to His bundle pacing (HBP) and conventional biventricular pacing (BVP). Background: HBP can correct left bundle branch block (LBBB) and may be an alternative cardiac resynchronization therapy (CRT) to BVP. Methods: Fourteen consecutive patients with heart failure (HF) and typical LBBB who required CRT were enrolled. The acute hemodynamic responses during HBP and BVP were compared using a micromanometer-tipped catheter inserted into the left ventricle (LV) before CRT. Each configuration was compared with AAI mode. A permanent HBP device was implanted when LBBB correction threshold was ≤1.5 V at 1.0 ms, and remaining patients were treated with BVP. Clinical and echocardiographic improvements were assessed during a 12-month follow-up period. Results: The LV contractile index (positive maximal rate of LV pressure rise [dP/dtmax]) increased similarly during HBP and BVP (18.8% ± 6.4% vs 18.0% ± 10.2%; P = 0.810). LV relaxation indices (negative dP/dtmax and tau) were significantly improved during HBP compared with BVP (negative dP/dtmax: 14.3% ± 5.5% vs 3.1% ± 8.1%; P < 0.001; tau: 7.2% ± 4.3% vs −0.8% ± 8.1%; P = 0.001). Nine (64%) patients received permanent HBP devices, while 5 patients were treated with BVP. The New York Heart Association functional class, LV ejection fraction, LV end-systolic volume, and B-type natriuretic peptide level improved in patients treated with HBP and BVP (all P < 0.05 vs baseline). Patients treated with HBP exhibited earlier and greater improvements of the LV ejection fraction and LV end-systolic volume than did those with BVP. Conclusions: HBP improves systolic function and LV relaxation in patients with HF and LBBB. CRT via HBP produced earlier and greater clinical responses than BVP.

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  106. Usefulness of the Snare Technique During Leadless Pacemaker Implantation for a Patient with a Severely Dilated Right Atrium. Open Access

    Hiramatsu T, Mizutani Y, Yanagisawa S, Sugiyama T, Yamashita D, Tajima A, Yonekawa J, Makino Y, Suzuki H, Ichimiya H, Uchida Y, Watanabe J, Kanashiro M, Inden Y, Murohara T

    International heart journal   Vol. 63 ( 1 ) page: 159 - 162   2022

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    We report here the case of a 92-year-old woman with atrial fibrillation bradycardia in which leadless pacemaker implantation was performed with a difficult delivery of the catheter sheath due to an extremely large right atrium. Using a snare technique with correction of the direction of the force on the catheter toward the right ventricle (RV) can result in successful delivery of the pacemaker catheter and stable placement of the pacemaker system in the RV septum. This specific snare technique has the potential to facilitate leadless pacemaker implantation safely in a severely dilated chamber of the heart, making this technique effective to use in clinical practice.

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  107. Evaluation of the Novel Automated Anti-Tachycardia Pacing Algorithm Successfully Terminating Sustained Monomorphic Ventricular Tachycardia in an Electrophysiology Study. Reviewed Open Access

    Yanagisawa S, Inden Y, Okajima T, Nakagomi T, Shimojo M, Watanabe R, Tsurumi N, Suzuki N, Suga K, Shibata R, Murohara T

    International heart journal   Vol. 63 ( 3 ) page: 633 - 638   2022

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    We report the usefulness of novel automated anti-tachycardia pacing (ATP) for ventricular tachycardia (VT) termination evaluated in an electrophysiology study. This intrinsic, automated ATP with an implanted cardiac resynchronization therapy-defibrillator successfully terminated the sustained VT, which had not been suppressed by repetitive burst pacing from the electrode catheter. The reproduction of programed pacing of the automated ATP by a right ventricular electrode catheter was effective in terminating VT, and this termination was absolute and reproducible. Further detailed assessment in an electrophysiology study could highlight the algorithm of the automated ATP and its possible benefit in terminating the reentrant VT.

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  108. Earliest pulmonary vein potential-guided cryoballoon ablation is associated with better clinical outcomes than conventional cryoballoon ablation: A result from two randomized clinical studies.

    Mizutani Y, Yanagisawa S, Kanashiro M, Yamashita D, Yonekawa J, Makino Y, Hiramatsu T, Ichimiya H, Uchida Y, Watanabe J, Ichimiya S, Inden Y, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 32 ( 11 ) page: 2933 - 2942   2021.11

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  109. Permanent His-bundle pacing using distal His-bundle electrogram-guided approach in patients with atrioventricular block.

    Suga K, Kato H, Inden Y, Yanagisawa S, Murakami H, Kada K, Tsuboi N, Murohara T

    Pacing and clinical electrophysiology : PACE   Vol. 44 ( 11 ) page: 1907 - 1917   2021.11

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  110. Incidence of Left Atrial Thrombus Development and Imaging Approach in Patients Scheduled for Repeat Catheter Ablation for Atrial Fibrillation. Reviewed

    Yanagisawa S, Inden Y, Riku S, Suga K, Furui K, Nakagomi T, Shimojo M, Okajima T, Shibata R, Murohara T

    The American journal of cardiology   Vol. 155   page: 52 - 63   2021.9

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    The risk for developing left atrial (LA) thrombi after initial catheter ablation for atrial fibrillation (AF) and requirements for imaging evaluation for thrombi screening at repeat ablation is unclear. This study aimed to assess the occurrence of thrombus development and frequency of any imaging study evaluating thrombus formation during repeat ablation for AF. Of 2,066 patients undergoing initial catheter ablation for AF with uninterrupted oral anticoagulation, 615 patients underwent repeat ablation after 258.0 (105.0–882.0) days. We investigated the factors associated with safety outcomes and requirements for thrombus screening. All patients underwent at least one imaging examination to screen for thrombi in the initial session; however, the examination rate decreased to 476 patients (77%) before the repeat session. The frequency of imaging evaluations was 5.0%, 11%, 21%, 84%, and 91% for transesophageal echocardiography and 18%, 33%, 49%, 98%, and 99% for any imaging modality at repeat ablation performed ≤60 days, ≤90 days, ≤180 days, >180 days, and >1 year after the initial session, respectively. Three patients (0.5%) developed LA thrombi at repeat ablation due to identifiable causes, and no patients experienced thromboembolic events when no imaging evaluation was performed. Multivariate analysis revealed that repeat ablation performed after >180 days, non-paroxysmal atrial arrhythmias, and lower left ventricular ejection fraction were predictors of thrombus development and severe spontaneous echocardiography contrast. In conclusion, the risk for thrombus development at repeat ablation for AF was low. There needs to be a risk stratification of the imaging screening for thrombi at repeat ablation.

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  111. Disappearance pattern and the last remaining earliest pulmonary vein potential during cryoballoon ablation in predicting recurrence and conduction gap site of pulmonary veins.

    Mizutani Y, Inden Y, Yanagisawa S, Kanashiro M, Makino Y, Satake A, Kurobe M, Ichimiya H, Uchida Y, Watanabe J, Ichimiya S, Murohara T

    Heart and vessels   Vol. 36 ( 8 ) page: 1190 - 1200   2021.8

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    DOI: 10.1007/s00380-021-01785-3

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  112. Dynamic Changes in Electrocardiogram Parameters After Epicardial Substrate Catheter Ablation of Brugada Syndrome. Reviewed Open Access

    Mamiya K, Inden Y, Yanagisawa S, Fujii A, Tomomatsu T, Okamoto H, Riku S, Suga K, Furui K, Nakagomi T, Shibata R, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 85 ( 8 ) page: 1283 - 1293   2021.7

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    Background: Catheter ablation (CA) is effective for recurrent episodes of ventricular fibrillation (VF) in Brugada syndrome (BrS). VF development in BrS is associated with several electrocardiogram (ECG) abnormalities. This study investigated changes in ECG parameters in high-risk BrS patients who underwent epicardial CA. Methods and Results: In all, 27 BrS patients were implanted with an implantable cardioverter-defibrillator (ICD). Patients were divided into 2 groups: (1) an ablation group (n=11) that underwent epicardial CA because of VF recurrence; and (2) a primary prevention (PP) group (n=16) with ICD implantation only. ECG parameters were evaluated before and 12 months after CA and compared with ECG parameters in the PP group. The T wave peak-to-end interval was significantly longer and the number of abnormal spikes in leads V1-V3 at the second, third, and fourth intercostal spaces was greater in the ablation than PP group. After ablation, ST levels and the sum of abnormal spikes in leads V1-V3 were significantly decreased. The mean (±SD) number of ICD shocks decreased markedly during a mean follow-up period of 42.0 months (from 3.8±3.7 to 0.2±0.4/year). Four patients had an ICD shock following the ablation procedure. Greater reductions in ST-segment elevation and abnormal spikes were observed in the group without than with VF recurrence. Conclusions: Improvements in surface ECG parameters appear to be associated with successful ablation in high-risk BrS patients.

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  113. The mechanism and prognosis of acute and late improvement in mitral regurgitation after cardiac resynchronization therapy.

    Okamoto H, Inden Y, Yanagisawa S, Fujii A, Tomomatsu T, Mamiya K, Riku S, Suga K, Furui K, Nakagomi T, Shibata R, Murohara T

    Heart and vessels   Vol. 36 ( 7 ) page: 986 - 998   2021.7

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  114. A case of heart failure complicated with double ventricular response triggered by beta blocker.

    Kazama S, Kondo T, Suga K, Yanagisawa S, Morimoto R, Okumura T, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 7 ( 3 ) page: 174 - 177   2021.3

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    DOI: 10.1016/j.hrcr.2020.12.004

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  115. Early improvement of daily physical activity after catheter ablation for atrial fibrillation in an accelerometer assessment: A prospective pilot study. Open Access

    Yanagisawa S, Inden Y, Fujii A, Sakamoto Y, Tomomatsu T, Mamiya K, Okamoto H, Murohara T, Shibata R

    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc   Vol. 26 ( 1 ) page: e12807   2021.1

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    DOI: 10.1111/anec.12807

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  116. Safety and efficacy of first-line cryoablation for para-hisian ventricular arrhythmias using a cryomapping protocol approach: A case series. Open Access

    Mizutani Y, Yanagisawa S, Kanashiro M, Inden Y, Murohara T

    Clinical case reports   Vol. 8 ( 12 ) page: 3248 - 3253   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Clinical Case Reports  

    DOI: 10.1002/ccr3.3401

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  117. Autopsy evaluation of the implantation site of a His bundle pacing lead demonstrating selective capture.

    Kato H, Igawa O, Suga K, Murakami H, Kada K, Tsuboi N, Yanagisawa S, Inden Y, Murohara T

    Pacing and clinical electrophysiology : PACE   Vol. 43 ( 11 ) page: 1412 - 1416   2020.11

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    DOI: 10.1111/pace.13989

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  118. Periprocedural Management of Cardiac Tamponade During Catheter Ablation for AF Under Uninterrupted DOAC and Warfarin Open Access

    Yanagisawa S.

    JACC: Clinical Electrophysiology   Vol. 6 ( 7 ) page: 786 - 795   2020.7

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    DOI: 10.1016/j.jacep.2020.02.005

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  119. The impact of the dominant frequency of body surface electrocardiography in patients with persistent atrial fibrillation.

    Murase Y, Inden Y, Shibata R, Yanagisawa S, Fujii A, Ando M, Otake N, Takenaka M, Funabiki J, Sakamoto Y, Murohara T

    Heart and vessels   Vol. 35 ( 7 ) page: 967 - 976   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Heart and Vessels  

    DOI: 10.1007/s00380-020-01563-7

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  120. Electrocardiogram characteristics of P wave associated with successful pulmonary vein isolation in patients with paroxysmal atrial fibrillation: Significance of changes in P-wave duration and notched P wave Open Access

    Yanagisawa Satoshi, Inden Yasuya, Okamoto Hiroya, Fujii Aya, Sakamoto Yusuke, Mamiya Keita, Tomomatsu Toshiro, Shibata Rei, Murohara Toyoaki

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   Vol. 25 ( 2 ) page: e12712   2020.3

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    DOI: 10.1111/anec.12712

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    Web of Science

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  121. Anatomical assessment of crosstalk phenomenon during laser balloon ablation with imaging in a patient with unusual atrial hypertrophy

    Yanagisawa Satoshi, Inden Yasuya, Okamoto Hiroya, Tomomatsu Toshiro, Fujii Aya, Mamiya Keita, Shibata Rei, Murohara Toyoaki

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 57 ( 1 ) page: 157 - 159   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10840-019-00632-w

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  122. Study design and protocol for evaluating the long-term prognosis of patients receiving his bundle pacing: A multicenter observational study. Open Access

    Yanagisawa S, Inden Y, Kato H, Suzuki H, Fujita M, Ishikawa S, Kanzaki Y, Kamikubo Y, Murase Y, Murohara T, Shibata R

    Journal of arrhythmia   Vol. 35 ( 5 ) page: 760 - 765   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Arrhythmia  

    DOI: 10.1002/joa3.12229

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  123. Correction to: Differences in prothrombotic response between the uninterrupted and interrupted apixaban therapies in patients undergoing cryoballoon ablation for paroxysmal atrial fibrillation: a randomized controlled study.

    Ando M, Inden Y, Yoshida Y, Sairaku A, Yanagisawa S, Suzuki H, Watanabe R, Takenaka M, Maeda M, Murohara T

    Heart and vessels   Vol. 34 ( 9 ) page: 1542   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Heart and Vessels  

    DOI: 10.1007/s00380-019-01424-y

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  124. T-wave changes of cardiac memory caused by frequent premature ventricular contractions originating from the right ventricular outflow tract.

    Sakamoto Y, Inden Y, Okamoto H, Mamiya K, Tomomatsu T, Fujii A, Yanagisawa S, Shibata R, Hirai M, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 30 ( 9 ) page: 1549 - 1556   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Cardiovascular Electrophysiology  

    DOI: 10.1111/jce.14008

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    PubMed

  125. Discontinuous contraction in the left ventricle assessed by 2-D speckle tracking echocardiography benefits from CRT.

    Fujii A, Inden Y, Yanagisawa S, Mamiya K, Okamoto H, Sakamoto Y, Tomomatsu T, Shibata R, Murohara T

    Pacing and clinical electrophysiology : PACE   Vol. 42 ( 9 ) page: 1204 - 1212   2019.9

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    DOI: 10.1111/pace.13759

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  126. Differences in prothrombotic response between the uninterrupted and interrupted apixaban therapies in patients undergoing cryoballoon ablation for paroxysmal atrial fibrillation: a randomized controlled study.

    Ando M, Inden Y, Yoshida Y, Sairaku A, Yanagisawa S, Suzuki H, Watanabe R, Takenaka M, Maeda M, Murohara T

    Heart and vessels   Vol. 34 ( 9 ) page: 1533 - 1541   2019.9

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    DOI: 10.1007/s00380-019-01370-9

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  127. Identification of precise accessory pathway using ultra-high-resolution three-dimensional mapping system: utility and feasibility in preliminary experience.

    Yanagisawa S, Inden Y, Fujii A, Sakamoto Y, Ichiyanagi H, Shibata R, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   Vol. 55 ( 2 ) page: 241 - 242   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Interventional Cardiac Electrophysiology  

    DOI: 10.1007/s10840-019-00582-3

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  128. His bundle pacing with unusual automaticity

    Yanagisawa Satoshi, Inden Yasuya, Shibata Rei, Murohara Toyoaki

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   Vol. 30 ( 6 ) page: 966 - 968   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jce.13904

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  129. Adjacentmultiple accessory pathways demonstrated on ultra-high-resolution mapping

    Yanagisawa Satoshi, Inden Yasuya, Murohara Toyoaki

    EUROPACE   Vol. 21 ( 5 ) page: 723   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/europace/euz044

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  130. Clinical significance of the timing of early recurrence of atrial arrhythmia after pulmonary vein isolation: a two-institution clinical study. Reviewed

    Murase Y, Inden Y, Imai H, Kyo S, Yanagisawa S, Fujii A, Sakamoto Y, Tomomatsu T, Murohara T

    Heart and vessels   Vol. 34 ( 5 ) page: 842 - 850   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00380-018-1295-1

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  131. Myocardial viability as shown by left ventricular lead pacing threshold and improved dyssynchrony by QRS narrowing predicts the response to cardiac resynchronization therapy. Reviewed

    Takenaka M, Inden Y, Yanagisawa S, Fujii A, Ando M, Funabiki J, Murase Y, Otake N, Sakamoto Y, Shibata R, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 30 ( 3 ) page: 311 - 319   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jce.13806

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  132. Uninterrupted Direct Oral Anticoagulant and Warfarin Administration in Elderly Patients Undergoing Catheter Ablation for Atrial Fibrillation: A Comparison With Younger Patients. Open Access

    Yanagisawa S, Inden Y, Fujii A, Ando M, Funabiki J, Murase Y, Takenaka M, Otake N, Ikai Y, Sakamoto Y, Shibata R, Murohara T

    JACC. Clinical electrophysiology   Vol. 4 ( 5 ) page: 592 - 600   2018.5

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    DOI: 10.1016/j.jacep.2018.02.013

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    PubMed

  133. Repression of Nitrogen Starvation Responses by Members of the Arabidopsis GARP-Type Transcription Factor NIGT1/HRS1 Subfamily.

    Kiba T, Inaba J, Kudo T, Ueda N, Konishi M, Mitsuda N, Takiguchi Y, Kondou Y, Yoshizumi T, Ohme-Takagi M, Matsui M, Yano K, Yanagisawa S, Sakakibara H

    The Plant cell   Vol. 30 ( 4 ) page: 925 - 945   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1105/tpc.17.00810

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  134. Renal function and risk of stroke and bleeding in patients undergoing catheter ablation for atrial fibrillation: Comparison between uninterrupted direct oral anticoagulants and warfarin administration

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Ikai Yoshihiro, Sakamoto Yusuke, Shibata Rei, Murohara Toyoaki

    HEART RHYTHM   Vol. 15 ( 3 ) page: 348 - 354   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.hrthm.2017.10.033

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  135. Assessment of autonomic nervous system modulation after novel catheter ablation techniques for atrial fibrillation using multiple short-term electrocardiogram recordings

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Kamikubo Yosuke, Kanzaki Yasunori, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Ikai Yoshihiro, Sakamoto Yusuke, Shibata Rei, Murohara Toyoaki

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 51 ( 1 ) page: 35 - 44   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10840-017-0295-x

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  136. An ECG Index of P-Wave Force Predicts the Recurrence of Atrial Fibrillation after Pulmonary Vein Isolation.

    Kanzaki Y, Inden Y, Ando M, Kamikubo Y, Ito T, Mizutani Y, Kato H, Fujii A, Yanagisawa S, Hirai M, Murohara T

    Pacing and clinical electrophysiology : PACE   Vol. 39 ( 11 ) page: 1191 - 1197   2016.11

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    DOI: 10.1111/pace.12956

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  137. Effect and Significance of Early Reablation for the Treatment of Early Recurrence of Atrial Fibrillation After Catheter Ablation.

    Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Ando M, Hirai M, Shibata R, Murohara T

    The American journal of cardiology   Vol. 118 ( 6 ) page: 833 - 841   2016.9

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    DOI: 10.1016/j.amjcard.2016.06.045

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  138. Body mass index is associated with prognosis in Japanese elderly patients with atrial fibrillation: an observational study from the outpatient clinic.

    Yanagisawa S, Inden Y, Yoshida N, Kato H, Miyoshi-Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Hirai M, Murohara T.

    Heart Vessels   Vol. 31 ( 9 ) page: 1553 - 61   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00380-015-0765-y

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  139. Decrease in B-Type Natriuretic Peptide Levels and Successful Catheter Ablation for Atrial Fibrillation in Patients with Heart Failure.

    Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Hirai M, Murohara T.

    Pacing Clin Electrophysiol.   Vol. 39 ( 3 ) page: 225 - 34   2016.3

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    DOI: 10.1111/pace.12788

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  140. Elevated Red Blood Cell Distribution Width Predicts Recurrence After Catheter Ablation for Atrial Fibrillation in Patients With Heart Failure - Comparison With Non-Heart Failure Patients. Open Access

    Yanagisawa S, Inden Y, Kato H, Miyoshi A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Hirai M, Murohara T.

    Circ J.   Vol. 80 ( 3 ) page: 627 - 38   2016

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    DOI: 10.1253/circj.CJ-15-1152

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  141. Differences in activated clotting time among uninterrupted anticoagulants during the periprocedural period of atrial fibrillation ablation.

    Nagao T, Inden Y, Yanagisawa S, Kato H, Ishikawa S, Okumura S, Mizutani Y, Ito T, Yamamoto T, Yoshida N, Hirai M, Murohara T

    Heart rhythm   Vol. 12 ( 9 ) page: 1972 - 8   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Heart Rhythm  

    DOI: 10.1016/j.hrthm.2015.04.016

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  142. Impact of cardiac resynchronization therapy-defibrillator implantation on the association between body mass index and prognosis in patients with heart failure.

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Ishikawa S, Kato H, Okumura S, Miyoshi-Fujii A, Nagao T, Yamamoto T, Mizutani Y, Ito T, Hirai M, Murohara T

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   Vol. 43 ( 3 ) page: 269 - 77   2015.9

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    DOI: 10.1007/s10840-015-0015-3

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  143. Alogliptin, a dipeptidyl peptidase-4 inhibitor, regulates the atrial arrhythmogenic substrate in rabbits.

    Yamamoto T, Shimano M, Inden Y, Takefuji M, Yanagisawa S, Yoshida N, Tsuji Y, Hirai M, Murohara T

    Heart rhythm   Vol. 12 ( 6 ) page: 1362 - 9   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Heart Rhythm  

    DOI: 10.1016/j.hrthm.2015.03.010

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  144. Efficacy and safety of apixaban in the patients undergoing the ablation of atrial fibrillation.

    Nagao T, Inden Y, Shimano M, Fujita M, Yanagisawa S, Kato H, Ishikawa S, Miyoshi A, Okumura S, Ohguchi S, Yamamoto T, Yoshida N, Hirai M, Murohara T

    Pacing and clinical electrophysiology : PACE   Vol. 38 ( 2 ) page: 155 - 63   2015.2

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    DOI: 10.1111/pace.12553

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    PubMed

  145. Feasibility and safety of uninterrupted dabigatran therapy in patients undergoing ablation for atrial fibrillation. Open Access

    Nagao T, Inden Y, Shimano M, Fujita M, Yanagisawa S, Kato H, Ishikawa S, Miyoshi A, Okumura S, Ohguchi S, Yamamoto T, Yoshida N, Hirai M, Murohara T

    Internal medicine (Tokyo, Japan)   Vol. 54 ( 10 ) page: 1167 - 73   2015

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Internal Medicine  

    DOI: 10.2169/internalmedicine.54.3520

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    PubMed

  146. Clinical characteristics and predictors of super-response to cardiac resynchronization therapy: a combination of predictive factors.

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Fujita M, Ohguchi S, Ishikawa S, Kato H, Okumura S, Miyoshi A, Nagao T, Yamamoto T, Hirai M, Murohara T

    Pacing and clinical electrophysiology : PACE   Vol. 37 ( 11 ) page: 1553 - 64   2014.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pace.12506

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  147. Clinical outcome of implantable cardioverter defibrillators with recalled and non-recalled leads in Japanese patients. Increased failure rate of the Sprint Fidelis lead.

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Ichiyanagi H, Fujita M, Ohguchi S, Ishikawa S, Kato H, Okumura S, Miyoshi A, Nagao T, Yamamoto T, Hirai M, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 78 ( 2 ) page: 353 - 9   2014

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    DOI: 10.1253/circj.cj-13-1040

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  148. Comparison of medically versus surgically treated acute type a aortic dissection in patients &lt;80 years old versus patients ≥80 years old. Reviewed

    Yanagisawa S, Yuasa T, Suzuki N, Hirai T, Yasuda N, Miki K, Yasuura K, Horiuchi K, Tanaka T

    The American journal of cardiology   Vol. 108 ( 3 ) page: 453 - 9   2011.8

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    DOI: 10.1016/j.amjcard.2011.03.067

    PubMed

  149. Programmed synthesis of tetraarylthiophenes through sequential C-H arylation.

    Yanagisawa S, Ueda K, Sekizawa H, Itami K

    Journal of the American Chemical Society   Vol. 131 ( 41 ) page: 14622 - 3   2009.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ja906215b

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  150. Prothrombotic Responses After Catheter Ablation for Atrial Fibrillation During Uninterrupted Oral Anticoagulant Agent Administration. Reviewed

      Vol. 5 ( 12 ) page: 1418-1427   2019.12

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jacep.2019.09.002

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    PubMed

  151. Vagal response in cryoballoon ablation of atrial fibrillation and autonomic nervous system: Utility of epicardial adipose tissue location Reviewed

    Yanagisawa Satoshi, Inden Yasuya, Mizutani Yoshiaki, Fujii Aya, Kamikubo Yosuke, Kanzaki Yasunori, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Hattori Tetsuyoshi, Shibata Rei, Murohara Toyoaki

    JOURNAL OF ARRHYTHMIA   Vol. 33 ( 4 ) page: 275-282   2017.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.joa.2017.03.001

    Web of Science

    PubMed

  152. Impaired renal function is associated with recurrence after cryoballoon catheter ablation for paroxysmal atrial fibrillation: A potential effect of non-pulmonary vein foci. Reviewed

    Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Ando M, Hirai M, Shibata R, Murohara T.

    J Cardiol.   Vol. 69 ( 1 ) page: 3-10   2017.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jjcc.2016.07.008

  153. Effect and Significance of Early Reablation for the Treatment of Early Recurrence of Atrial Fibrillation After Catheter Ablation. Reviewed

    Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Ando M, Hirai M, Shibata R, Murohara T.

    Am J Cardiol.   Vol. 118 ( 6 ) page: 833-841   2016.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.amjcard.2016.06.045

  154. Impact of cardiac resynchronization therapy-defibrillator implantation on the association between body mass index and prognosis in patients with heart failure. Reviewed

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Ishikawa S, Kato H, Okumura S, Miyoshi-Fujii A, Nagao T, Yamamoto T, Mizutani Y, Ito T, Hirai M, Murohara T.

    J Interv Card Electrophysiol.   Vol. 43 ( 3 ) page: 269-277   2015.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10840-015-0015-3

  155. Clinical characteristics and predictors of super-response to cardiac resynchronization therapy: a combination of predictive factors. Reviewed

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Fujita M, Ohguchi S, Ishikawa S, Kato H, Okumura S, Miyoshi A, Nagao T, Yamamoto T, Hirai M, Murohara T.

    Pacing Clin Electrophysiol.   Vol. 37 ( 11 ) page: 1553-1564   2014.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pace.12506

  156. Clinical outcome of implantable cardioverter defibrillators with recalled and non-recalled leads in Japanese patients. Increased failure rate of the Sprint Fidelis lead. Reviewed

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Ichiyanagi H, Fujita M, Ohguchi S, Ishikawa S, Kato H, Okumura S, Miyoshi A, Nagao T, Yamamoto T, Hirai M, Murohara T.

    Circ J.   Vol. 78 ( 2 ) page: 353-359   2014.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  157. Comparison of medically versus surgically treated acute type a aortic dissection in patients <80 years old versus patients >=80 years old. Reviewed

    Yanagisawa S, Yuasa T, Suzuki N, Hirai T, Yasuda N, Miki K, Yasuura K, Horiuchi K, Tanaka T.

    Am J Cardiol.   Vol. 108 ( 3 ) page: 453-459   2011.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  158. The prognostic value of treadmill exercise testing in very elderly patients: Heart rate recovery as a predictor of mortality in octogenarians. Reviewed

    Yanagisawa S, Miki K, Yasuda N, Hirai T, Suzuki N, Tanaka T.

    Europace.   Vol. 13 ( 1 ) page: 114-120   2011.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/europace/euq422

  159. Clinical outcomes and prognostic factor for acute heart failure in nonagenarians: Impact of hypoalbuminemia on mortality. Reviewed

    Yanagisawa S, Miki K, Yasuda N, Hirai T, Suzuki N, Tanaka T.

    Int J Cardiol.   Vol. 145 ( 3 ) page: 574-576   2010.12

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcard.2010.05.061

  160. Poor tolerance of beta-blockers by elderly patients with heart failure. Reviewed

    Yanagisawa S, Suzuki N, Tanaka T.

    Clin Interv Aging.   Vol. 5   page: 365-368   2010.11

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2147/CIA.S15158

  161. Right ventricular outflow tract obstruction: metastatic thyroid carcinoma. Reviewed

    Yanagisawa S, Suzuki Y, Yuasa T, Tanaka T.

    J Am Coll Cardiol.   Vol. 55 ( 11 ) page: 1159   2010.3

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  162. Clinical diagnosis of Schistosoma japonicum infection complicating infective endocarditis and liver cirrhosis. Reviewed

    Yanagisawa S, Yuasa T, Tanaka T.

    Intern Med.   Vol. 44 ( 11 ) page: 1001-1005   2010

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.49.3121

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Books 2

  1. 人体のメカニズムから学ぶ臨床工学 循環器治療学 頻脈性不整脈の発生機序

    柳澤 哲、室原豊明( Role: Joint author)

    メジカルビュー社  2017 

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    Total pages:7   Language:Japanese Book type:Textbook, survey, introduction

  2. BIO Clinica, TOPICS 心房細動カテーテルアブレーション治療の周術期抗凝固療法

    柳澤 哲( Role: Joint author)

    北隆館  2018.11 

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    Language:Japanese Book type:Scholarly book

MISC 1

  1. Septal coronary artery fistula after left bundle branch area pacing assessed by multi-imaging modalities and shunt volume quantification

    Kato H, Yanagisawa S, Ota R, Murakami H, Kada K, Tsuboi N, Inden Y, Murohara T

    Pacing and clinical electrophysiology : PACE   Vol. 45 ( 11 ) page: 1299 - 1302   2022.11

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    Language:English   Publisher:PACE - Pacing and Clinical Electrophysiology  

    Septal coronary artery fistula is a rare but concerning complication of left bundle branch area pacing (LBBAP). We report the case of an 82-year-old man who was indicated for cardiac resynchronization therapy and underwent LBBAP. The patient had no chest symptoms during or after implantation. Postoperative echocardiography demonstrated a new abnormal tunnel inside the interventricular septum (IVS) and shunt flow from the IVS toward the right ventricle. Coronary angiography confirmed a septal coronary artery fistula, which might have been formed by failed deep screw attempts. Since the shunt volume assessed by the Qp/Qs was small, the patient was treated conservatively.

    DOI: 10.1111/pace.14548

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    PubMed

Research Project for Joint Research, Competitive Funding, etc. 2

  1. 微小栓子シグナル信号解析法を用いた心筋焼灼時の血栓リスク評価と血液凝固マーカーとの関連探索

    2023 - 2024

    鈴木謙三記念医科学応用研究財団 研究助成金 

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    Authorship:Principal investigator 

  2. 加速度センサー搭載型活動量計を用いた日常生活の身体活動強度評価と心房細動アブレーション治療後の予後改善への試み

    2016 - 2017

    鈴木謙三記念医科学応用研究財団 研究助成金 

    柳澤 哲

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. 頸動脈波の微小栓子シグナル信号解析を用いた、有効で安全な次世代不整脈治療法の確立

    Grant number:23K07549  2023.4 - 2027.3

    科学研究費補助金   基盤研究(C)

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    Authorship:Principal investigator 

  2. 新しいヒス束ペースメーカの長期予後と刺激伝導系の解明を目指した多施設共同研究

    Grant number:19K17558  2019.4 - 2023.3

    科学研究費助成事業  若手研究

    柳澤 哲

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    本研究は、新しいペーシングシステムであるヒス束ペーシングの有効性と安全性、さらにその長期的な予後について多施設で検討を行うものである。日本では、ヒス束ペースメーカは臨床診療に導入されてから間もないため、各施設ともまだ症例数が少なく、その適応や効果について模索している段階である。本研究の目的は、ヒス束ペースメーカを対象として前向きに多施設の症例登録・共同研究を行い、多くのヒス束ペースメーカの症例を収集して長期の追跡を行うことで、その有効性と安全性だけでなく、心機能への影響や長期的な予後について検証を行うものである。
    ヒス束ペースメーカは2017年本邦に導入された全く新しいペーシングシステムである。刺激伝導系であるヒス束を直接捕捉・ペーシングすることにより、従来の右心室ペーシングで懸念された非効率的な心室同期不全や、心拍出量低下から引き起こされる心不全発症を回避できる可能性がある。日本では臨床診療に導入されてから間もないため、各施設ともまだ症例数が少なくその適応や効果について模索している段階である。本研究の目的は、ヒス束ペースメーカ症例を対象として前向きで多施設の共同研究を行い、ヒス束ペースメーカの有効性と安全性、心機能への影響や長期的な予後について検証を行うものである。
    今年度は研究プロトコル・計画について、主管実施施設である当病院の生命倫理審査委員会からの承認が下りた。引き続き共同研究機関において、それぞれの倫理審査委員会から研究実施の承認が得られた。最初にWEBシステムでの症例登録システムを構築し、多施設での症例登録や入力がすみやかに行えるように準備と管理を行った。その後症例の登録と研究を開始しており、これまでに約1年間で25例のヒス束ペースメーカシステム植え込み症例の登録が得られた。現在登録完了施設は6施設からなり、年齢も50から80歳台と多岐にわたっている。同時に、個々の症例について6か月後の短期評価項目の調査入力を行っている状況である。また、本研究のデザイン/プロトコル論文を作成して投稿し、日本不整脈心電学会関連の雑誌に掲載となった。
    症例の組み入れ登録を開始しているが、現時点ではやや症例の見積もり数と比較して不足がちな状況である。
    今後も引き続き症例登録を続けて、できるだけ多くの症例登録を目指す。また得られた結果をもとに分析を開始していく予定である。

  3. Lifestyle intervention for improvement of the outcome after catheter ablation for atrial fibrillation

    Grant number:16K19399  2016.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Yanagisawa Satoshi

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    Authorship:Principal investigator 

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    The present study was aimed to evaluate physical activities and motor function by using an accelerometer in patients who underwent catheter ablation for atrial fibrillation. After the follow-up period of 6 months, mean daily steps and maximum daily steps were increased from pre-ablation to post-ablation procedure. Moreover, the exercise intensity was increased after the ablation. The improvement of physical activities and motor function was found in the early phase after the ablation procedure. The results may be explained by the effect of suppressing atrial fibrillation and improvement of cardiac hemodynamics.

  4. Evaluation by Frequency Analysis of Surface Electrocardiogram and Rotor Mapping in Left Atrum

    Grant number:15K09076  2015.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Yasuya Inden

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    Authorship:Coinvestigator(s) 

    Dominant frequency (DF) of atrial fibrillation (AF) reflects atrial electrical activity. We retrospectively investigated 78 patients who underwent catheter ablation due to persistent AF. The high DF of lead aVL and V1 was a predictor of arrhythmia recurrence after persistent AF ablation.
    Electrical rotors may be targets in ablations for persistent atrial fibrillation. Unipolar electrograms in left atrium were recorded with using basket catheter, and we analyzed rotational activities by NavX. rotors were recognized in anterior and posterior LA. We performed PV isolation and delivered RF application to the rotors. AF terminated in some patients and more patients maintained sinus rhythm. Rotors could be able to be recognized by use of basket catheter and EnSite system in patients with persistent AF and may be the target of ablation in persistent AF next to PVI.