Updated on 2024/09/20

写真a

 
NAKASHIMA Hirotaka
 
Organization
Nagoya University Hospital Geriatrics Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer
External link

Degree 2

  1. 博士（医学） （ 2015.9   名古屋大学 ） 

  2. 学士(医学) （ 2009.3   大阪大学 ） 

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Research Interests 7

  1. orexin

  2. delirium

  3. exercise

  4. dementia

  5. 活動量計

  6. Frailty Index

  7. 睡眠

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Research Areas 1

  1. Others / Others  / geriatrics

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Current Research Project and SDGs 6

  1. Frailty Index-laboratory

  2. せん妄と睡眠の関係

  3. 認知症患者における時計描画試験と脳血流の関連

  4. Cilostazol for Prevention of Pneumonia: Systematic Review

  5. 認知症と運動

  6. せん妄と血漿中オレキシンの関係

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Research History 5

  1. Nagoya University   Nagoya University Hospital Geriatrics   Lecturer

    2022.10

  2. 医療法人和光会山田病院   医局

    2019.4 - 2022.9

  3. 名古屋大学医学部附属病院地域医療センター病院助教

    2015.4 - 2019.3

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    Country：Japan

  4. 名古屋大学医学部附属病院老年内科医員

    2011.4 - 2015.3

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    Country：Japan

  5. 名古屋大学医学部附属病院卒後臨床研修キャリア形成支援センター研修医

    2009.4 - 2011.3

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    Country：Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2015.3

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    Country： Japan

  2. Osaka University   Faculty of Medicine

    - 2009.3

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    Country： Japan

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Professional Memberships 4

  1. 日本老年医学会

  2. 日本認知症学会

  3. 日本在宅医学会

  4. 日本内科学会

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Awards 1

  1. Young Best Award

    2015  

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    Country：Japan

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Papers 28

  1. Frailty Index Based on Common Laboratory Tests for Patients Starting Home-Based Medical Care Reviewed

    Nakashima H., Watanabe K., Komiya H., Fujisawa C., Yamada Y., Sakai T., Tajima T., Umegaki H.

    Journal of the American Medical Directors Association   Vol. 25 ( 9 ) page： 105114   2024.9

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of the American Medical Directors Association  

    Objectives: To determine whether a Frailty Index based on laboratory tests (FI-lab) is associated with clinical outcomes independently of a standard nonlaboratory Frailty Index (FI-clinical) in older patients starting home-based medical care. Design: Secondary analysis of data from a multicenter prospective cohort study. Setting and Participants: Patients aged ≥65 years who were starting home-based medical care services provided by doctors and nurses at Nagoya, Japan. Methods: We calculated FI-lab (proportion of abnormal results out of 25 commonly tested laboratory parameters) and FI-clinical using 42 items based on data obtained at enrollment. The primary outcome was mortality within 2 years after starting home-based medical care. A sensitivity analysis was also conducted with 1-year mortality as the outcome. Other outcomes included hospitalization and nursing home admission within 2 years. Results: In total, 188 patients (mean age 79.9 ± 10.2 years, 57.5% male) were included. The median FI-lab was 0.40 [interquartile range (IQR) 0.29-0.50] and the median FI-clinical was 0.32 (IQR 0.24-0.43). Sixty-nine patients (36.7%) died within 2 years of starting home-based medical care. A Cox proportional hazards regression analysis including age, sex, FI-lab, and FI-clinical as independent variables revealed that FI-lab was associated with 2-year mortality independently of FI-clinical [FI-lab per 0.1 unit, odds ratio (OR) 1.49, 95% CI 1.25-1.77; FI-clinical per 0.1 unit, OR 1.13, 95% CI 0.90-1.41]. The sensitivity analysis showed similar results for 1-year mortality. Neither FI-lab nor FI-clinical was associated with hospitalization or nursing home admission within 2 years. Conclusions and Implications: FI-lab was associated with 2-year mortality in patients starting home-based medical care, independently of FI-clinical, and may be useful for risk assessment in this population. Studies with larger sample sizes are needed.

    DOI： 10.1016/j.jamda.2024.105114

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  2. Combined use of the Clinical Frailty Scale and laboratory tests in acutely hospitalized older patients. Reviewed International journal

    Hirotaka Nakashima, Masaaki Nagae, Hitoshi Komiya, Chisato Fujisawa, Kazuhisa Watanabe, Yosuke Yamada, Tomihiko Tajima, Shuzo Miyahara, Tomomichi Sakai, Hiroyuki Umegaki

    Aging clinical and experimental research   Vol. 35 ( 9 ) page： 1927 - 1935   2023.6

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    AIMS: To evaluate the Clinical Frailty Scale (CFS) and a Frailty Index based on laboratory tests (FI-lab) in terms of what each assesses about frailty and to determine the appropriateness of combined use of these two frailty scales. METHODS: This was a prospective observational cohort study in an acute geriatric ward of a university hospital. The FI-lab is the proportion of laboratory parameters that yield abnormal results from a total of 23. The FI-lab and CFS were assessed at admission. Data on activities of daily living (ADL), cognition, geriatric syndromes, and comorbidities were also collected. Main outcomes were in-hospital mortality and 90-day mortality after admission. RESULTS: In total, 378 inpatients (mean age 85.2 ± 5.8 years, 59.3% female) were enrolled. ADL and cognition correlated strongly with the CFS (Spearman's |r|> 0.60) but weakly with the FI-lab (|r|< 0.30). Both the CFS and FI-lab correlated weakly with geriatric syndromes and comorbidities (|r|< 0.40). The correlation between the CFS and FI-lab was also weak (r = 0.28). The CFS and FI-lab were independently associated with in-hospital mortality and 90-day mortality after admission. The Akaike information criterion was lower for models using both the CFS and FI-lab than for models using either tool alone. CONCLUSIONS: The CFS and FI-lab each reflected only some of the aspects of frailty in acutely hospitalized older patients. The model fit was better when the two frailty scales were used together to assess the mortality risk than when either was used alone.

    DOI： 10.1007/s40520-023-02477-w

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  3. Dual Sensory Impairment Predicts an Increased Risk of Postdischarge Falls in Older Patients

    Yamada Y., Nakashima H., Nagae M., Watanabe K., Fujisawa C., Komiya H., Tajima T., Sakai T., Satake S., Takeya Y., Umeda-Kameyama Y., Umegaki H.

    Journal of the American Medical Directors Association   Vol. 25 ( 9 ) page： 105123   2024.9

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    Language：English   Publisher：Journal of the American Medical Directors Association  

    Objectives: The purpose of this study was to determine the associations of vision impairment, hearing impairment, and comorbid vision and hearing impairment [ie, dual sensory impairment (DSI)] on admission to hospital with falls within 3 months of discharge in older patients. Design: This prospective multicenter study included patients admitted to and discharged from geriatric wards at 3 university hospitals and 1 national medical center in Japan between October 2019 and July 2023. Setting and Participants: Of 1848 individuals enrolled during the study period, 1141 were excluded, leaving 707 for inclusion in the analysis. Methods: Participants’ background factors were compared in terms of whether they had a fall during the 3 months postdischarge. Logistic regression analysis was then performed using the presence or absence of falls after discharge as the objective variable. Three models were created using vision impairment, hearing impairment, and DSI as covariates. Other covariates included physical function, cognitive function, and depression. In addition, logistic regression analysis was performed with falls during hospitalization as the objective variable. Results: DSI was significantly more common in the falls group (P = .004). Logistic regression analysis showed that the risk of falls after discharge was higher in patients with DSI (odds ratio 3.432, P = .006) than in those with vision or hearing impairment alone. When adjusted for physical function, cognitive function, depression, and discharge location, DSI was significantly associated with an increased risk of falls after discharge (odds ratio 3.107, P = .021). The association between DSI and falls during hospitalization did not reach statistical significance, but a trend was observed. Conclusions and Implications: This study is the first to show an association between DSI and falls after discharge. Simple interventions for patients with DSI may be effective in preventing falls, and we suggest that they be actively implemented early during hospitalization.

    DOI： 10.1016/j.jamda.2024.105123

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  4. Association of marital relationship with quality of life among older adults with mild cognitive impairment and mild dementia

    Fujisawa C., Nakashima H., Komiya H., Watanabe K., Yamada Y., Tajima T., Umegaki H.

    Geriatrics and Gerontology International   Vol. 24 ( 6 ) page： 646 - 647   2024.6

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    Language：English   Publisher：Geriatrics and Gerontology International  

    DOI： 10.1111/ggi.14868

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  5. Relationship between cognitive function and phase angle measured with a bioelectrical impedance system Reviewed

    Yamada Y., Watanabe K., Fujisawa C., Komiya H., Nakashima H., Tajima T., Umegaki H.

    European Geriatric Medicine   Vol. 15 ( 1 ) page： 201 - 208   2024.2

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    Language：English   Publisher：European Geriatric Medicine  

    Aim: Investigate the relationship between cognitive function and phase angle, a measure of muscle quality. Findings: Phase angle consistently decreased with worsening general cognition in individuals with Alzheimer's dementia or amnesic mild cognitive impairment in men. Message: Our study strengthened the findings of the very few previous studies indicating that low muscle quality is associated with poor cognitive function.

    DOI： 10.1007/s41999-023-00894-8

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  6. Objective physical function declines in the absence of subjective physical complaints among patients with amnestic mild cognitive impairments and mild alzheimer’s disease

    Fujisawa C., Umegaki H., Sugimoto T., Nakashima H., Komiya H., Watanabe K., Nagae M., Yamada Y., Tajima T., Sakai T., Sakurai T.

    European Geriatric Medicine     2024

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    Language：English   Publisher：European Geriatric Medicine  

    Purpose: To examine the extent to which patients with amnestic mild cognitive impairment (aMCI) or Alzheimer’s disease (AD) perceive their own physical decline. Methods: This study included 4450 outpatients (1008 normal cognition [NC], 1605 aMCI, and 1837 mild AD) who attended an initial visit to a memory clinic between July 2010 and June 2021. Their physical function was assessed by the Timed Up and Go test, one-leg standing test, and grip strength. For physical complaints, data were obtained on reports of fear of falling and dizziness or staggering. Logistic regression analysis was performed to compare the patients’ physical function and complaints for each stage of NC, aMCI, and mild AD. Results: Objective physical function declined from aMCI and the mild AD stage, but subjective physical complaints decreased by 20–50% in aMCI and 40–60% in mild AD compared with the NC group. Conclusion: As objective physical functional declined from the aMCI stage onward, subjective physical complaints decreased. This suggests a need for objective assessment of physical function in aMCI and mild AD patients even when they have no physical complaints in the clinical setting.

    DOI： 10.1007/s41999-024-01005-x

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  7. Comparing prevalence and types of potentially inappropriate medications among patient groups in a post-acute and secondary care hospital Reviewed

    Nakashima H., Ando H., Umegaki H.

    Scientific Reports   Vol. 13 ( 1 ) page： 14543   2023.12

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Scientific Reports  

    Reducing potentially inappropriate medications (PIMs) is a challenge in post-acute care hospitals. Some PIMs may be associated with patient characteristics and it may be useful to focus on frequent PIMs. This study aimed to identify characteristic features of PIMs by grouping patients as in everyday clinical practice. A retrospective review of medical records was conducted for 541 patients aged 75 years or older in a Japanese post-acute and secondary care hospital. PIMs on admission were identified using the Screening Tool for Older Person’s Appropriate Prescriptions for Japanese. The patients were divided into four groups based on their primary disease and reason for hospitalization: post-acute orthopedics, post-acute neurological disorders, post-acute others, and subacute. Approximately 60.8% of the patients were taking PIMs, with no significant difference among the four patient groups in terms of prevalence of PIMs (p = 0.08). However, characteristic features of PIM types were observed in each patient group. Hypnotics and nonsteroidal anti-inflammatory drugs were common in the post-acute orthopedics group, multiple antithrombotic agents in the post-acute neurological disorders group, diuretics in the post-acute others group, and hypnotics and diuretics in the subacute group. Grouping patients in clinical practice revealed characteristic features of PIM types in each group.

    DOI： 10.1038/s41598-023-41617-0

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  8. Relationship Between Non-Cognitive Intrinsic Capacity and Activities of Daily Living According to Alzheimer’s Disease Stage Reviewed

    Fujisawa C., Umegaki H., Sugimoto T., Nakashima H., Nagae M., Komiya H., Watanabe K., Yamada Y., Sakurai T.

    Journal of Alzheimer's Disease   Vol. 96 ( 3 ) page： 1115 - 1127   2023.11

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    Language：English   Publisher：Journal of Alzheimer's Disease  

    Background: Few studies have examined the relationship between non-cognitive factors and activities of daily living (ADL) according to Alzheimer’s disease (AD) stage. Objective: We aimed to identify the differences in non-cognitive factors according to AD stages and their involvement in basic and instrumental ADL performance by using intrinsic capacity (IC) in groups with cognition ranging from normal to moderate or severe AD. Methods: We enrolled 6397 patients aged ≥ 65 years who visited our memory clinic. Non-cognitive IC was assessed using the locomotion, sensory, vitality, and psychological domains. Multiple logistic regression was performed to identify how non-cognitive IC declines over the AD course and examine the correlation between non-cognitive IC and basic and instrumental ADL performance. Results: Non-cognitive IC declined from the initial AD stage and was significantly correlated with both basic and instrumental ADL performance from the aMCI stage through all AD stages. In particular, the relationship between IC and basic ADL was stronger in mild and moderate to severe AD than in the aMCI stage. On the other hand, the relationship between IC and instrumental ADL was stronger in aMCI than in later AD stages. Conclusions: The results show non-cognitive factors, which decline from the aMCI stage, are correlated with ADL performance from the aMCI stage to almost all AD stages. Considering that the relationship strength varied by ADL type and AD stage, an approach tailored to ADL type and AD stage targeting multiple risk factors is likely needed for effectively preventing ADL performance declines.

    DOI： 10.3233/JAD-230786

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  9. Intrinsic capacity in acutely hospitalized older adults. Reviewed International journal

    Masaaki Nagae, Hiroyuki Umegaki, Hitoshi Komiya, Hirotaka Nakashima, Chisato Fujisawa, Kazuhisa Watanabe, Yosuke Yamada, Shuzo Miyahara

    Experimental gerontology   Vol. 179   page： 112247 - 112247   2023.8

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    OBJECTIVES: We aimed to examine the association between intrinsic capacity (IC) and adverse outcomes of hospitalization. DESIGN: A prospective observational cohort study. SETTING AND PARTICIPANTS: We recruited patients aged 65 years or older who were admitted to the geriatric ward of an acute hospital between Oct 2019 and Sep 2022. MEASUREMENTS: Each of the five IC domains (locomotion, cognition, vitality, sensory, and psychological capacity) was graded into three levels, and the composite IC score was calculated (0, lowest; 10, highest). Hospital-related outcomes were defined as in-hospital death, hospital-associated complications (HACs), length of hospital stay, and frequency of discharge to home. RESULTS: In total, 296 individuals (mean age 84.7 ± 5.4 years, 42.7 % males) were analyzed. Mean composite IC score was 6.5 ± 1.8, and 95.6 % of participants had impairment in at least one IC domain. A higher composite IC score was independently associated with lower frequency of in-hospital death (odds ratio [OR] 0.59) and HACs (OR 0.71), higher frequency of discharge to home (OR 1.50), and shorter length of hospital stay (β = -0.24, p < 0.01). The locomotion, cognition, and psychological domains were independently associated with the occurrence of HACs, discharge destination, and length of hospital stay. CONCLUSION: Evaluating IC was feasible in the hospital setting and was associated with outcomes of hospitalization. For older inpatients with decreased IC, integrated management may be required to achieve functional independence.

    DOI： 10.1016/j.exger.2023.112247

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  10. Short physical performance battery discriminates clinical outcomes in hospitalized patients aged 75 years and over Reviewed International coauthorship

    Fujita Kosuke, Nakashima Hirotaka, Kako Masato, Shibata Atsushi, Cheng Yu-ting, Tanaka Shinya, Nishida Yoshihiro, Kuzuya Masafumi

    ARCHIVES OF GERONTOLOGY AND GERIATRICS   Vol. 90   page： 104155   2020

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    DOI： 10.1016/j.archger.2020.104155

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  11. Plasma orexin-A levels in patients with delirium Reviewed

    Nakashima Hirotaka, Umegaki Hiroyuki, Yanagawa Madoka, Komiya Hitoshi, Watanabe Kazuhisa, Kuzuya Masafumi

    PSYCHOGERIATRICS   Vol. 19 ( 6 ) page： 628 - 630   2019.11

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    Authorship：Lead author,　Corresponding author   Language：English  

    DOI： 10.1111/psyg.12444

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  12. Plasma orexin-A-like immunoreactivity levels and renal function in patients in a geriatric ward Reviewed

    Nakashima Hirotaka, Umegaki Hiroyuki, Yanagawa Madoka, Komiya Hitoshi, Watanabe Kazuhisa, Kuzuya Masafumi

    PEPTIDES   Vol. 118   page： 170092   2019.8

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    Authorship：Lead author,　Corresponding author   Language：English  

    DOI： 10.1016/j.peptides.2019.170092

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  13. Complaint of poor night sleep is correlated with physical function impairment in mild Alzheimer's disease patients Reviewed

    Fujisawa Chisato, Umegaki Hiroyuki, Nakashima Hirotaka, Kuzuya Masafumi, Toba Kenji, Sakurai Takashi

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 19 ( 2 ) page： 171 - 172   2019.2

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  14. 高齢心不全患者におけるトルバプタン使用経験からの考察 Reviewed

    山本 有厳, 柳川 まどか, 大西 丈二, 服部 孝二, 中嶋 宏貴, 伊奈 孝一郎, 梅垣 宏行, 葛谷 雅文

    日本老年医学会雑誌   Vol. 55 ( 4 ) page： 704 - 704   2018.10

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    Language：Japanese   Publisher：(一社)日本老年医学会  

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  15. Maximum gait speed is associated with a wide range of cognitive functions in Japanese older adults with a Clinical Dementia Rating of 0.5

    Umegaki Hiroyuki, Makino Taeko, Yanagawa Madoka, Nakashima Hirotaka, Kuzuya Masafumi, Sakurai Takashi, Toba Kenji

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 18 ( 9 ) page： 1323-1329   2018.9

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    DOI： 10.1111/ggi.13464

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  16. Correlation between regional cerebral blood flow and body composition in healthy older women: A single-photon emission computed tomography study

    Fujisawa Chisato, Umegaki Hiroyuki, Kato Takashi, Nakashima Hirotaka, Kuzuya Masafumi, Ito Kengo, Toba Kenji, Sakurai Takashi

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 18 ( 8 ) page： 1303-1304   2018.8

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    DOI： 10.1111/ggi.13444

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  17. Cilostazol for the prevention of pneumonia: a systematic review. Reviewed

    Nakashima H, Watanabe K, Umegaki H, Suzuki Y, Kuzuya M

    Pneumonia (Nathan Qld.)   Vol. 10   page： 3   2018.4

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s41479-018-0046-5

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  18. Physical Function Differences Between the Stages From Normal Cognition to Moderate Alzheimer Disease

    Fujisawa Chisato, Umegaki Hiroyuki, Okamoto Kazushi, Nakashima Hirotaka, Kuzuya Masafumi, Toba Kenji, Sakurai Takashi

    JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION   Vol. 18 ( 4 ) page： 368.e9-368.e15   2017.4

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    DOI： 10.1016/j.jamda.2016.12.079

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  19. Neuropsychological differences in Alzheimer's disease patients with or without type2 diabetes mellitus

    Yanagawa Madoka, Umegaki Hiroyuki, Makino Taeko, Nakashima Hirotaka, Kuzuya Masafumi

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 16 ( 11 ) page： 1232 - 1235   2016.11

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  20. Neuroanatomical correlates of error types on the Clock Drawing Test in Alzheimer's disease patients Reviewed

    Nakashima Hirotaka, Umegaki Hiroyuki, Makino Taeko, Kato Katsuhiko, Abe Shinji, Suzuki Yusuke, Kuzuya Masahumi

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 16 ( 7 ) page： 777 - 784   2016.7

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    DOI： 10.1111/ggi.12550

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  21. The prevalence of homebound individuals in the elderly population: a survey in a city area in Japan

    Umegaki Hiroyuki, Yanagawa Madoka, Nakashima Hirotaka, Makino Taeko, Kuzuya Masafumi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 77 ( 3 ) page： 439 - 446   2015.8

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  22. The prevalence of homebound individuals in the elderly population: a survey in a city area in Japan. Reviewed

    Hiroyuki Umegaki, Madoka Yanagawa, Hirotaka Nakashima, Taeko Makino, Masafumi Kuzuya

    Nagoya journal of medical science   Vol. 77 ( 3 ) page： 439 - 46   2015.8

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    Being homebound has been reported to be associated with a number of conditions. In the current study, the incidence of homebound individuals was surveyed in an urban city area in Japan. The city office randomly enrolled 5,000 residents of Nagoya City aged 65 and over. A questionnaire was sent to their principal caregivers by mail, and 3,444 (68.9 %) subjects returned the survey. The investigators obtained the totally anonymous data from the city office. This study was approved by the Ethics Committee of Nagoya University Graduate School of Medicine. In the present study, the data of 3,053 (61.1 %) subjects for whom complete sets of data were available were employed for statistical analysis. The questionnaire included the following items: age, sex, the status of public long-term care insurance certification (none, support-level, care-level), self-rated health (good, fair, poor, very poor), states of living (single living, with only spouse, with other family members), and the frequency of outside excursions per a week (every day, once in a few day, one a week, rarely). An individual was defined as being homebound if his or her frequency of outside excursions was less than once per week. he incidence of the homebound elderly in the elderly population over 65 years old was 14.4 % in the current study. The status of certification in public long-term care insurance was associated with being homebound. Self-rated health was significantly worse in homebound individuals than in those non-homebound. The current survey found 14.4 % of the elderly was home-bound in a large city in Japan.

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  23. Relationship between small cerebral white matter lesions and cognitive function in patients with Alzheimer's disease and amnestic mild cognitive impairment

    Makino Taeko, Umegaki Hiroyuki, Suzuki Yusuke, Yanagawa Madoka, Nonogaki Zen, Nakashima Hirotaka, Kuzuya Masafumi

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 14 ( 4 ) page： 819 - 826   2014.10

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  24. Burden reduction of caregivers for users of care services provided by the public long-term care insurance system in Japan

    Umegaki Hiroyuki, Yanagawa Madoka, Nonogaki Zen, Nakashima Hirotaka, Kuzuya Masafumi, Endo Hidetoshi

    ARCHIVES OF GERONTOLOGY AND GERIATRICS   Vol. 58 ( 1 ) page： 130 - 133   2014

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  25. Cognitive impairments and functional declines in older adults at high risk for care needs

    Umegaki Hiroyuki, Suzuki Yusuke, Yanagawa Madoka, Nonogaki Zen, Nakashima Hirotaka, Kuzuya Masufumi, Endo Hidetoshi

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 13 ( 1 ) page： 77 - 82   2013.1

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  26. Dysphagia in older adults at high risk of requiring care

    UMEGAKI Hiroyuki, SUZUKI Yusuke, YANAGAWA Madoka, NONOGAKI Zen, NAKASHIMA Hirotaka, ENDO Hidetoshi

      Vol. 12 ( 2 ) page： 359 - 361   2012.4

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  27. Dysphagia in older adults at high risk of requiring care

    UMEGAKI Hiroyuki, SUZUKI Yusuke, YANAGAWA Madoka, NONOGAKI Zen, NAKASHIMA Hirotaka, ENDO Hidetoshi

      Vol. 12 ( 2 ) page： 359 - 361   2012.4

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  28. Dysphagia in older adults at high risk of requiring care

    Umegaki Hiroyuki, Suzuki Yusuke, Yanagawa Madoka, Nonogaki Zen, Nakashima Hirotaka, Endo Hidetoshi

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 12 ( 2 )   2012.4

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Books 1

  1. レジデントノート

    （ Role： Contributor ,  入院中に生じた低栄養）

    羊土社  2023.11 

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MISC 18

  1. 実地臨床における「高齢者の在宅医療・介護サービスガイドライン2019」の活用と今後の課題 在宅療養者に対する高齢者総合機能評価 ガイドラインの活用と今後の課題

    中嶋 宏貴, 鈴木 裕介, 葛谷 雅文

    日本老年医学会雑誌   Vol. 57 ( Suppl. ) page： 39 - 39   2020.7

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  2. ARDSと考えられる急性呼吸不全を呈した播種性クリプトコッカス感染症の1例

    長永 真明, 史 榕茜, 中嶋 宏貴, 葛谷 雅文

    日本老年医学会雑誌   Vol. 56 ( 4 ) page： 554 - 554   2019.10

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  3. 運営母体による訪問看護ステーション(ST)の業務実態に関する調査報告(第2報)

    辻 典子, 鈴木 裕介, 中嶋 宏貴, 広瀬 貴久, 葛谷 雅文

    日本老年医学会雑誌   Vol. 56 ( 4 ) page： 555 - 555   2019.10

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  4. 老年内科入院患者の薬剤調整における使用薬剤数と薬物相互作用の変化

    渡邉 雄貴, 森 桂, 市川 和哉, 中嶋 宏貴, 千崎 康司, 永井 拓, 梅垣 宏行, 山田 清文, 葛谷 雅文

    日本老年医学会雑誌   Vol. 56 ( 4 ) page： 556 - 556   2019.10

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  5. 老年内科入院患者の薬剤調整における使用薬剤数と薬物相互作用の変化

    渡邉 雄貴, 森 桂, 市川 和哉, 中嶋 宏貴, 千崎 康司, 永井 拓, 梅垣 宏行, 山田 清文, 葛谷 雅文

    日本老年医学会雑誌   Vol. 56 ( 4 ) page： 556 - 556   2019.10

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  6. 訪問看護ステーション(ST)の現状と課題についての考察

    辻 典子, 鈴木 裕介, 中嶋 宏貴, 廣瀬 貴久, 葛谷 雅文

    日本在宅医療連合学会大会プログラム・講演抄録集   Vol. 1回   page： 327 - 327   2019.7

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  7. Short Physical Performance Batteryは75歳以上の入院期高齢患者の生命予後予測に有用である

    藤田 康介, 田中 伸弥, 加古 誠人, 柴田 篤志, 中嶋 宏貴, 西田 佳宏, 葛谷 雅文

    日本老年医学会雑誌   Vol. 56 ( Suppl. ) page： 101 - 101   2019.5

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  8. 物忘れ外来患者における低ナトリウム血症と歩行障害

    藤沢 知里, 梅垣 宏行, 小宮 仁, 中嶋 宏貴, 山田 洋介, 渡邊 一久, 柳川 まどか, 葛谷 雅文, 山森 有夏, 櫻井 孝

    日本老年医学会雑誌   Vol. 56 ( Suppl. ) page： 122 - 122   2019.5

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  9. 新聞、学会誌、裁判例データベースにおける「痴呆」から「認知症」への変遷

    小宮 仁, 梅垣 宏行, 渡邊 一久, 藤沢 知里, 中嶋 宏貴, 柳川 まどか, 鈴木 裕介, 葛谷 雅文

    日本老年医学会雑誌   Vol. 56 ( Suppl. ) page： 171 - 171   2019.5

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  10. 愛知県の訪問看護ステーション(ST)の現状と課題についての考察

    辻 典子, 鈴木 裕介, 広瀬 貴久, 中嶋 宏貴, 葛谷 雅文

    日本老年医学会雑誌   Vol. 56 ( Suppl. ) page： 162 - 162   2019.5

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  11. 在宅療養患者のリビングウィルの有無に関連する因子の検討

    山田 洋介, 梅垣 宏行, 渡邊 一久, 小宮 仁, 中嶋 宏貴, 柳川 まどか, 黄 継賢, 葛谷 雅文

    日本老年医学会雑誌   Vol. 56 ( Suppl. ) page： 177 - 177   2019.5

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  12. 在宅療養患者における血清総コレステロール値と初回入院に関する検討

    渡邊 一久, 梅垣 宏行, 柳川 まどか, 中嶋 宏貴, 藤沢 知里, 小宮 仁, 山田 洋介, 葛谷 雅文

    日本老年医学会雑誌   Vol. 56 ( Suppl. ) page： 177 - 177   2019.5

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  13. せん妄患者における血漿中オレキシン濃度

    中嶋 宏貴, 梅垣 宏行, 柳川 まどか, 小宮 仁, 渡邊 一久, 葛谷 雅文

    日本老年医学会雑誌   Vol. 56 ( Suppl. ) page： 144 - 144   2019.5

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  14. 「高齢者在宅医療・介護サービスガイドライン2019年版」の臨床応用に向けて 高齢者在宅医療・介護サービスガイドライン作成からみえてきた今後の課題

    鈴木 裕介, 中嶋 宏貴, 葛谷 雅文

    日本老年医学会雑誌   Vol. 56 ( Suppl. ) page： 52 - 52   2019.5

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  15. 入院時に容易に入手できる情報からせん妄を予測する

    中嶋 宏貴, 梅垣 宏行, 柳川 まどか, 小宮 仁, 渡邊 一久, 葛谷 雅文

    Dementia Japan   Vol. 32 ( 3 ) page： 513 - 513   2018.9

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  16. 在宅高齢者における不適切処方と入院との関連の検討

    梅垣 宏行, 野村 秀樹, 神田 茂, 紙谷 博子, 渡邉 雄貴, 中嶋 宏貴, 小宮 仁, 渡邊 一久, 葛谷 雅文

    日本老年医学会雑誌   Vol. 55 ( Suppl. ) page： 141 - 141   2018.5

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  17. 独居で訪問診療を受けている患者の在宅療養継続に関連する因子

    中嶋 宏貴, 梅垣 宏行, 神田 茂, 野村 秀樹, 紙谷 博子, 鈴木 裕介, 葛谷 雅文

    日本老年医学会雑誌   Vol. 55 ( Suppl. ) page： 146 - 146   2018.5

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  18. 【高齢者の栄養】高齢者の栄養評価

    中嶋 宏貴, 葛谷 雅文

    Geriatric Medicine   Vol. 55 ( 7 ) page： 731 - 735   2017.7

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    高齢者では栄養障害の頻度が高い。栄養障害は死亡や合併症などのリスク因子であるが、早期発見と介入によりこれらの転帰を改善できる。このため栄養状態の評価が重要である。栄養評価は2段階で構成される。まず、簡便な方法で栄養スクリーニングを行い、栄養障害のリスクのある者を抽出する。外来患者では受診ごとの体重測定から始めるとよいかもしれない。スクリーニングで栄養障害のリスクがあると判定された場合には、栄養アセスメントを行う。栄養アセスメントツールを用いるなどして栄養障害の有無を確定し、病歴や身体所見などから栄養障害の原因を追究する。(著者抄録)

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Presentations 34

  1. 訪問診療を受け始める高齢者における、血液検査から算出したフレイル度と生命予後の関係

    中嶋宏貴、渡邊一久、小宮仁、藤沢知里、山田洋介、田島富彦、坂井智達、梅垣宏行

    第66回日本老年医学会学術集会  2024.6.13 

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    Event date： 2024.6

    Language：Japanese   Presentation type：Oral presentation (general)  

  2. 併存症を有するフレイル高齢者に対する治療デザイン「フレイル高齢者の入院関連合併症予防」 Invited

    中嶋宏貴

    第66回日本老年医学会学術集会  2024.6.15 

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    Event date： 2024.6

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

  3. 亜急性期病院における入院時のPIMs(Potentially Inappropriate Medications)：患者群別の特徴

    中嶋宏貴、安藤弘道、梅垣宏行

    第65回日本老年医学会学術集会  2023.6.17 

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    Event date： 2023.6

    Language：Japanese   Presentation type：Oral presentation (general)  

  4. 亜急性期病院における入院時のPotentially Inappropriate Medications（PIMs）：患者群別の特徴

    Geriatrics Frontier Meeting 

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    Event date： 2023.4

    Presentation type：Symposium, workshop panel (nominated)  

  5. 大学病院退院時の訪問診療依頼：5年間の変遷

    中嶋宏貴, 鈴木裕介, 梅垣宏行, 葛谷雅文

    第19回日本在宅医学会大会 

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    Event date： 2017.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  6. 大学病院におけるかかりつけ医紹介窓口：活動報告

    中嶋宏貴, 鈴木裕介, 梅垣宏行, 葛谷雅文

    第59回日本老年医学会学術集会 

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    Event date： 2017.6

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  7. 若手によるトピックのCritical Review

    中嶋宏貴, 山本浩一, 冨田尚希, 石井伸弥, 小島太郎

    第59回日本老年医学会学術集会 

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    Event date： 2017.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  8. 高齢者の体重減少の原因―入院精査の結果―

    中嶋宏貴, 鈴木裕介, 梅垣宏行, 葛谷雅文

    日本老年医学会東海地方会 

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    Event date： 2016.9

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  9. シロスタゾールの肺炎予防効果 ―メタアナリシス―

    中嶋宏貴, 渡邊一久, 梅垣宏行, 鈴木裕介, 葛谷雅文

    日本在宅医学会大会 

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    Event date： 2016.7

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  10. うがいによる上気道感染の予防 ―メタアナリシス―

    中嶋宏貴, 梅垣宏行, 鈴木裕介, 葛谷雅文

    日本老年医学会学術集会 

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    Event date： 2016.6

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  11. 入院予約手続きの簡略化による病診連携強化の取り組み

    中嶋宏貴, 紙谷博子, 柳川まどか, 梅垣宏行, 鈴木裕介, 葛谷雅文

    日本老年医学会東海地方会 

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    Event date： 2015.9

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  12. 認知症高齢者の食事支援　明日から役立つ評価・介入のポイント

    中嶋宏貴

    東三河地域連携栄養カンファレンス 

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    Event date： 2015.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  13. 時計描画試験によるドネペジルの効果予測　十字分割線を描く患者では効果が乏しい可能性

    中嶋宏貴, 梅垣宏行, 牧野多恵子, 柳川まどか, 鈴木裕介, 葛谷雅文

    日本老年医学会学術集会 

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    Event date： 2015.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  14. Neural correlates of the Clock Drawing Test : Error types and regional cerebral blood flow International conference

    IAGG Master Class on Ageing in Asia 

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    Event date： 2014.6

    Language：English   Presentation type：Poster presentation  

    Country：Korea, Republic of  

  15. アルツハイマー型認知症患者の 時計描画試験の誤りのパターンと脳血流の関連

    中嶋宏貴, 梅垣宏行, 牧野多恵子, 柳川まどか, 野々垣禅, 鈴木裕介, 葛谷雅文

    日本老年医学会学術集会 

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    Event date： 2014

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  16. アルツハイマー型認知症患者の時計描画試験における中心点のずれと脳血流との関連

    中嶋宏貴, 梅垣宏行, 柳川まどか, 野々垣禅, 牧野多恵子, 鈴木裕介, 葛谷雅文

    日本老年医学会学術集会 

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    Event date： 2013

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  17. 被介護者の施設入所希望に影響する因子の解析

    中嶋宏貴, 梅垣宏行, 野々垣禅, 柳川まどか, 葛谷雅文

    日本老年医学会学術集会 

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    Event date： 2012

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  18. CVポート感染は稀ではない

    中嶋宏貴, 梅垣宏行, 服部孝二, 広瀬貴久, 伊奈孝一郎, 鈴木裕介, 林登志雄, 葛谷雅文

    日本老年医学会東海地方会 

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    Event date： 2012

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  19. 三環系抗うつ薬の中断症候群

    中嶋宏貴, 鈴木裕介, 梅垣宏行, 葛谷雅文

    日本老年医学会東海地方会 

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    Event date： 2011

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  20. CVポート感染は稀ではない International conference

    中嶋宏貴, 梅垣宏行, 服部孝二, 広瀬貴久, 伊奈孝一郎, 鈴木裕介, 林登志雄, 葛谷雅文

    日本老年医学会東海地方会  2012 

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    Language：Japanese   Presentation type：Poster presentation  

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  21. 高齢者の体重減少の原因―入院精査の結果― International conference

    中嶋宏貴, 鈴木裕介, 梅垣宏行, 葛谷雅文

    日本老年医学会東海地方会  2016.9.17 

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    Language：Japanese   Presentation type：Poster presentation  

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  22. 認知症高齢者の食事支援 明日から役立つ評価・介入のポイント International conference

    中嶋宏貴

    東三河地域連携栄養カンファレンス  2015.9.19 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  23. 被介護者の施設入所希望に影響する因子の解析 International conference

    中嶋宏貴, 梅垣宏行, 野々垣禅, 柳川まどか, 葛谷雅文

    日本老年医学会学術集会  2012 

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    Language：Japanese   Presentation type：Poster presentation  

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  24. 若手によるトピックのCritical Review International conference

    中嶋宏貴, 山本浩一, 冨田尚希, 石井伸弥, 小島太郎

    第59回日本老年医学会学術集会  2017.6.14 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  25. 時計描画試験によるドネペジルの効果予測 十字分割線を描く患者では効果が乏しい可能性 International conference

    中嶋宏貴, 梅垣宏行, 牧野多恵子, 柳川まどか, 鈴木裕介, 葛谷雅文

    日本老年医学会学術集会  2015.6.12 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  26. 大学病院退院時の訪問診療依頼：5年間の変遷 International conference

    中嶋宏貴, 鈴木裕介, 梅垣宏行, 葛谷雅文

    第19回日本在宅医学会大会  2017.6.17 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  27. 大学病院におけるかかりつけ医紹介窓口：活動報告 International conference

    中嶋宏貴, 鈴木裕介, 梅垣宏行, 葛谷雅文

    第59回日本老年医学会学術集会  2017.6.14 

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    Language：Japanese   Presentation type：Poster presentation  

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  28. 入院予約手続きの簡略化による病診連携強化の取り組み International conference

    中嶋宏貴, 紙谷博子, 柳川まどか, 梅垣宏行, 鈴木裕介, 葛谷雅文

    日本老年医学会東海地方会  2015.9.26 

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    Language：Japanese   Presentation type：Poster presentation  

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  29. 三環系抗うつ薬の中断症候群 International conference

    中嶋宏貴, 鈴木裕介, 梅垣宏行, 葛谷雅文

    日本老年医学会東海地方会  2011 

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    Language：Japanese   Presentation type：Poster presentation  

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  30. シロスタゾールの肺炎予防効果 ―メタアナリシス― International conference

    中嶋宏貴, 渡邊一久, 梅垣宏行, 鈴木裕介, 葛谷雅文

    日本在宅医学会大会  2016.7.16 

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    Language：Japanese   Presentation type：Poster presentation  

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  31. アルツハイマー型認知症患者の時計描画試験における中心点のずれと脳血流との関連 International conference

    中嶋宏貴, 梅垣宏行, 柳川まどか, 野々垣禅, 牧野多恵子, 鈴木裕介, 葛谷雅文

    日本老年医学会学術集会  2013 

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    Language：Japanese   Presentation type：Poster presentation  

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  32. アルツハイマー型認知症患者の 時計描画試験の誤りのパターンと脳血流の関連 International conference

    中嶋宏貴, 梅垣宏行, 牧野多恵子, 柳川まどか, 野々垣禅, 鈴木裕介, 葛谷雅文

    日本老年医学会学術集会  2014 

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    Language：Japanese   Presentation type：Poster presentation  

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  33. うがいによる上気道感染の予防 ―メタアナリシス― International conference

    中嶋宏貴, 梅垣宏行, 鈴木裕介, 葛谷雅文

    日本老年医学会学術集会  2016.6.8 

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    Language：Japanese   Presentation type：Poster presentation  

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  34. Neural correlates of the Clock Drawing Test : Error types and regional cerebral blood flow

    IAGG Master Class on Ageing in Asia  2014.6.23 

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    Language：English   Presentation type：Poster presentation  

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To the head of Presentations.▲

Research Project for Joint Research, Competitive Funding, etc. 1

  1. 腕時計型の活動量計を用いたせん妄の早期診断

    Grant number：31-1-031  2023.4 - 2025.3

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\2000000

To the head of Research Project for Joint Research, Competitive Funding, etc..▲

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. Development of pharmacological treatment for delirium: analysis of cerebrospinal fluid and interventional study

    Grant number：16K21082  2016.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Hirotaka Nakashima, Kuzuya masafumi, Umegaki hiroyuki, Yanagawa madoka

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    Authorship：Principal investigator 

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    We had changed the research plan to "Evaluation of the association between plasma orexin-A levels in patients with delirium." We enrolled 70 patients who were admitted to the geriatric ward, and we evaluated delirium and plasma orexin-A levels. As the result, plasma orexin-A levels did not have any association with delirium.
    We obtained two additional results from this study. First, plasma orexin-A levels were negatively correlated with renal function. Second, preexisting impaired ADL(activities of daily living) and the severity of diseases on admission could strongly predict the development of delirium.

To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲
 

Teaching Experience (On-campus) 14

  1. フレイル、サルコペニア、ロコモティブシンドローム

    2024

  2. 高齢者総合機能評価

    2024

  3. 高齢者総合機能評価

    2023

  4. フレイル、サルコペニア、ロコモティブシンドローム

    2023

  5. Comprehensive Geriatric Assessment

    2022

  6. 老年医学（ポリファーマシー、摂食嚥下障害）

    2017

  7. 高齢者救急、地域包括ケア

    2017

    　詳細を見る

    医学生、臨床実習中の講義

  8. 高齢者救急

    2017

    　詳細を見る

    初期研修医に対する入職時オリエンテーション

  9. 高齢者救急

    2016

    　詳細を見る

    初期研修医に対する入職時オリエンテーション

  10. 高齢者救急、地域包括ケア

    2016

    　詳細を見る

    医学生、臨床実習中の講義

  11. 老年医学（ポリファーマシー、摂食嚥下障害）

    2016

  12. 高齢者救急、地域包括ケア

    2015

    　詳細を見る

    医学生、臨床実習中の講義

  13. 高齢者救急

    2015

    　詳細を見る

    初期研修医に対する入職時オリエンテーション

  14. 高齢者救急

    2014

    　詳細を見る

    初期研修医に対する入職時オリエンテーション

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To the head of Teaching Experience (On-campus).▲

Teaching Experience (Off-campus) 1

  1. Comprehensive Geriatric Assessment

    2022 （Nagoya University）

    　More details

    Level：Undergraduate (specialized)  Country：Japan

    researchmap

To the head of Teaching Experience (Off-campus).▲
 

Social Contribution 5

  1. 学びましょう、認知症のこと

    Role(s)：Lecturer

    認知症の人と家族の会愛知県支部  認知症支援講座  2024.9

  2. 高齢者救急、高齢者総合機能評価

    Role(s)：Lecturer

    2023.12

  3. ケアマネ研究会、神経疾患

    Role(s)：Lecturer

    2023.10

  4. 高齢者の栄養

    Role(s)：Lecturer

    2023.8

  5. 認知症になった方の気持ちを理解しよう

    Role(s)：Commentator

    岐阜県北方町医療介護福祉連絡協議会  在宅医療推進フォーラム  2022.9

To the head of Social Contribution.▲