Faculty Profiles - TAOKA Toshiaki

Papers - TAOKA Toshiaki

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Global and region-specific analyses of apparent diffusion coefficient in dentatorubral-pallidoluysian atrophy

Kin T., Hirano M., Taoka T., Furiya Y., Kataoka H., Kichikawa K., Ueno S.

American Journal of Neuroradiology Vol. 27 ( 7 ) page： 1463 - 1466 2006.8

Language：English Publishing type：Research paper (scientific journal) Publisher：American Journal of Neuroradiology

BACKGROUND AND PURPOSE: Dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant spinocerebellar ataxia. Techniques for the quantitative assessment of neurodegenerative lesions remain to be established in this disease. We attempted to quantify global and region-specific neurodegeneration in DRPLA using analysis of apparent diffusion coefficient (ADC) maps. METHODS: Diffusion-weighted images (b = 1000 s/mm2) by echo-planar sequences were obtained with the use of a 1.5T clinical scanner. Whole-brain histogram and region of interest (ROI) analyses of ADC values as well as conventional MR imaging studies were performed in 6 patients with genetically confirmed DRPLA. RESULTS: Histograms demonstrated significantly higher mean ADC values in the patients than in age-and sex-matched control subjects (P < .01). ROI analysis revealed that the patients had significantly higher ADC values in the cerebellum and globus pallidus, preferentially affected regions (P < .05), but not in the thalamus, the region relatively spared in this disease. ADC values in the white matter were higher only in patients with adult-onset disease. Histogram analyses could more sensitively identify abnormalities than ROI analyses, because the former avoided errors associated with setting ROIs and thus had smaller P values on statistical analysis than the latter. CONCLUSIONS: Histogram ADC analyses were more sensitive for the detection of neurodegeneration in DRPLA than ROI analyses, whereas ROI analyses revealed regional alterations reflecting the distribution of pathologic changes. Thus, histogram and ROI analyses complement each other and may permit the sensitive, quantitative evaluation of neurodegeneration in DRPLA, especially that involving the globus pallidus showing normal T2 signals.

Scopus

Evaluation of arteriosclerotic changes in the intracranial carotid artery using the calcium score obtained on plain cranial computed tomography scan: Correlation with angiographic changes and clinical outcome International journal

Toshiaki Taoka, Satoru Iwasaki, Hiroyuki Nakagawa, Masahiko Sakamoto, Akio Fukusumi, Katsutoshi Takayama, Takeshi Wada, Kaoru Myochin, Shinji Hirohashi, Kimihiko Kichikawa

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY Vol. 30 ( 4 ) page： 624 - 8 2006.7

Language：English Publishing type：Research paper (scientific journal) Publisher：LIPPINCOTT WILLIAMS & WILKINS

Purpose: This study evaluated the correlation between quantified calcification of the carotid siphon and arteriosclerotic changes on angiography as well as clinical outcome. We used the calcium score obtained from intracranial carotid arteries on plain CT.
Method/Materials: We examined carotid siphons of 72 consecutive patients who had undergone both plain CT and angiography of the brain. We calculated calcium scores of the carotid siphon. Arteriosclerotic changes on angiography were categorized as "smooth," "irregular," or "stenosis." We assessed the correlation between the scores and arteriosclerotic changes both in the carotid siphon and the bifurcation. We reviewed clinical records approximately 2 years after examination and evaluated the scores of patients who did and did not experience cerebral strokes.
Results: In the evaluation between angiographic findings of siphon and calcium score of the siphon, there were statistically significant differences between the "smooth" and "irregular", "irregular" and "stenosis" and the "smooth" and "stenosis". In the evaluation between angiographic findings of bifurcation and the score of the siphon, a statistically significant difference was only seen between "smooth" and "stenosis". No significant differences in calcium scores were observed between patients groups who did or did not experience a cerebral stroke.
Conclusions: There were a positive correlation between calcium scores on CT and angiographic changes of arteriosclerosis in the siphon as well as bifurcation, indicating angiographic changes can be predicted using calcium scores. However, the degree of calcification in the siphon cannot be used to predict the possibility of a future cerebral stroke.

DOI： 10.1097/00004728-200607000-00012

Web of Science

PubMed

White matter T2 hyperintensity development and clinical deterioration after status epilepticus in a patient with dentatorubral-pallidoluysian atrophy International journal

M Takamure, M Hirano, T Taoka, S Ueno

CLINICAL NEUROLOGY AND NEUROSURGERY Vol. 108 ( 5 ) page： 482 - 5 2006.7

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

Serial T2-weighted magnetic resonance imaging in a 29-year-old woman with juvenile type dentatorubral-pallidoluysian atrophy (DRPLA) demonstrated that a cerebral white matter hyperintensity appeared within 2 months after status epilepticus and persisted for more than 20 months. The patient had rapidly progressive mental regression and became akinetic after status epilepticus. The chronological relationship between the signal changes and the clinical deterioration suggested that the epilepsy, at least in part, contributed to the progression of white matter degeneration, the hallmark of DRPLA. (c) 2005 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.clineuro.2005.01.011

Web of Science

Scopus

PubMed

Serial therapy-induced changes in tumor shape in cervical cancer and their impact on assessing tumor volume and treatment response Reviewed

NA Mayr, WTC Yuh, T Taoka, JZ Wang, DH Wu, JF Montebello, SL Meeks, AC Paulino, VA Magnotta, M Adli, JI Sorosky, MV Knopp, JM Buatti

AMERICAN JOURNAL OF ROENTGENOLOGY Vol. 187 ( 1 ) page： 65 - 72 2006.7

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER ROENTGEN RAY SOC

OBJECTIVE. The purpose of this study was to evaluate the patterns and distribution of tumor shape and its temporal change during radiation therapy (RT) in cervical cancer and the effect of tumor configuration changes on the correlation between region of interest (ROI)-based and diameter-based MRI tumor measurement.
MATERIALS AND METHODS. Serial MRI examinations (T1-weighted and T2-weighted images) were performed in 60 patients (age range, 29-75 years; mean, 53.3 years) with advanced cervical cancer (stages IB2-IVB/recurrent) who were treated with RT at four time points: start of RT, during RT (at 2-2.5 and at 4-5 weeks of RT), and post-RT. Tumor configuration was classified qualitatively into oval, lobulated, and complex based on MR film review. Two methods of tumor volume measurement were compared: ellipsoid computation of three orthogonal diameters (diameter based) and ROI volumetry by delineating the entire tumor volume on the MR workstation (ROI based). Temporal changes of tumor shape and the respective tumor volumes measured by the two methods were analyzed using linear regression analysis.
RESULTS. Most tumors (70%) had a non-oval (lobulated and complex) shape before RT and became increasingly irregular during and after RT 84% at 2-2.5 weeks of RT (p = 0.037), 86% (p = 0.025) at 4-5 weeks, and 96% post-RT (p = 0.010), compared with 70% pre-RT. Diameter-based and ROI-based measurement correlated well before RT (r = 0.89) but not during RT (r = 0.68 at 2-2.5 weeks, r = 0.67 at 4-5 weeks of RT).
CONCLUSION. Most cervical cancers are not oval in shape pretherapy, and they become increasingly irregular during and after therapy because of nonconcentric tumor shrinkage. ROI-based volumetry, which can optimally measure irregular volumes, may provide better response assessment during treatment than diameter-based measurement.

DOI： 10.2214/AJR.05.0039

Web of Science

PubMed

Taoka T., Iwasaki S., Nakagawa H., Sakamoto M., Fukusumi A., Takayama K., Wada T., Myochin K., Hirohashi S., Kichikawa K.

Journal of Computer Assisted Tomography Vol. 30 ( 4 ) page： 624 - 628 2006.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Computer Assisted Tomography

PURPOSE:: This study evaluated the correlation between quantified calcification of the carotid siphon and arteriosclerotic changes on angiography as well as clinical outcome. We used the calcium score obtained from intracranial carotid arteries viewed on plain CT. METHOD/MATERIALS:: We examined carotid siphons of 72 consecutive patients who had undergone both plain CT and angiography of the brain. We calculated calcium scores of the carotid siphon. Arteriosclerotic changes on angiography were categorized as "smooth," "irregular," or "stenosis." We assessed the correlation between the scores and arteriosclerotic changes both in the carotid siphon and the bifurcation. We reviewed clinical records approximately 2 years after examination and evaluated the scores of patients who did and did not experience cerebral strokes. RESULTS:: In the evaluation between angiographic findings of siphon and calcium score of the siphon, there were statistically significant differences between the "smooth" and "irregular", "irregular" and "stenosis" and the "smooth" and "stenosis". In the evaluation between angiographic findings of bifurcation and the score of the siphon, a statistically significant difference was only seen between "smooth" and "stenosis". No significant differences in calcium scores were observed between patients groups who did or did not experience a cerebral stroke. CONCLUSIONS:: There were a positive correlation between calcium scores on CT and angiographic changes of arteriosclerosis in the siphon as well as bifurcation, indicating angiographic changes can be predicted using calcium scores. However, the degree of calcification in the siphon cannot be used to predict the possibility of a future cerebral stroke. Copyright © 2006 by Lippincott Williams & Wilkins.

DOI： 10.1097/00004728-200607000-00012

Scopus

Pituitary stalk compression by the dorsum sellae: possible cause for late childhood onset growth disorders International journal

T Taoka, S Iwasaki, S Okamoto, M Sakamoto, H Nakagawa, S Otake, M Fujioka, S Hirohashi, K Kichikawa

MAGNETIC RESONANCE IMAGING Vol. 24 ( 5 ) page： 651 - 6 2006.6

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Purpose: The purpose of this study was to evaluate the relationship between pituitary stalk compression by the dorsum sellae and clinical or laboratory findings in short stature children.
Materials and Methods: We retrospectively reviewed magnetic resonance images of the pituitary gland and pituitary stalk for 34 short stature children with growth hormone (GH) deficiency and 24 age-matched control cases. We evaluated the degree of pituitary stalk compression caused by the dorsum sellae. Body height, GH level, pituitary height and onset age of the short stature were statistically compared between cases of pituitary stalk compression with associated stalk deformity and cases without compression.
Results: Compression of the pituitary stalk with associated stalk deformity was seen in nine cases within the short stature group. There were no cases observed in the control group. There were no significant differences found for body height, GH level and pituitary height between the cases of pituitary stalk compression with associated stalk deformity and cases without compression. However, a significant difference was seen in the onset age between cases with and without stalk compression.
Conclusion: Pituitary stalk compression with stalk deformity caused by the dorsum sellae was significantly correlated with late childhood onset of short stature. (C) 2006 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.mri.2005.12.015

Web of Science

Scopus

PubMed

Diffusion anisotropy and diffusivity of white matter tracts within the temporal stem in Alzheimer disease: evaluation of the "tract of interest" by diffusion tensor tractography.

Taoka T, Iwasaki S, Sakamoto M, Nakagawa H, Fukusumi A, Myochin K, Hirohashi S, Hoshida T, Kichikawa K

AJNR. American journal of neuroradiology Vol. 27 ( 5 ) page： 1040 - 5 2006.5

Diffusion anisotropy and diffusivity of white matter tracts within the temporal stem in Alzheimer disease: Evaluation of the "tract of interest" by diffusion tensor tractography

Taoka T., Iwasaki S., Sakamoto M., Nakagawa H., Fukusumi A., Myochin K., Hirohashi S., Hoshida T., Kichikawa K.

American Journal of Neuroradiology Vol. 27 ( 5 ) page： 1040 - 1045 2006.5

Language：English Publishing type：Research paper (scientific journal) Publisher：American Journal of Neuroradiology

PURPOSE: Our aim was to determine whether diffusion anisotropy and diffusivity of white matter tracts of the temporal stem in patients with Alzheimer (AD) can be evaluated independently by using diffusion tensor tractography. MATERIALS AND METHODS: Subjects included 15 patients with AD (11 women and 4 men; mean age, 74 years) and 15 age-matched control subjects (11 women and 4 men; mean age, 72 years). Diffusion tensor images were acquired by using echo-planar imaging. We drew tractographies of the uncinate fasciculus, inferior occipitofrontal fasciculus, and Meyer's loop, with diffusion tensor analysis software. We measured diffusion anisotropy, diffusivity, and the number of voxels along the "tracts of interest" and used the Student t test to compare results between patients with AD and controls. RESULTS: Values of diffusion anisotropy of the bilateral uncinate fasciculus and left inferior occipitofrontal fasciculus were significantly lower for patients with AD than for controls. Also, values of diffusivity in the bilateral uncinate fasciculus were significantly greater for patients with AD than for controls. There was no significant difference in diffusion anisotropy or diffusivity along Meyer's loop between the 2 groups. There was no significant difference in the number of voxels included in all constructed tracts between patients with AD and controls. CONCLUSION: White matter tracts of the temporal stem can be evaluated independently by using diffusion tensor tractography, which appears to be a promising technique for determining changes in white matter in degenerative diseases.

Scopus

Apparent diffusion coefficient in dentatorubral-pallidoluysian atrophy Reviewed

Tesseki Kin, Makito Hirano, Toshiaki Taoka, Hiroshi Kataoka, Foshiko Furiya, Hirohide Asai, Kimihiko Kichikawa, Satoshi Ueno

ANNALS OF NEUROLOGY Vol. 60 page： S53 - S53 2006

Diffusion tensor imaging in cases with visual field defect after anterior temporal lobectomy

Taoka T., Sakamoto M., Iwasaki S., Nakagawa H., Fukusumi A., Hirohashi S., Taoka K., Kichikawa K., Hoshida T., Sakaki T.

American Journal of Neuroradiology Vol. 26 ( 4 ) page： 797 - 803 2005.12

Language：English Publishing type：Research paper (scientific journal) Publisher：American Journal of Neuroradiology

BACKGROUND AND PURPOSE: Visual defect due to optic radiation injury is a complication of temporal lobectomy for temporal epilepsy. To investigate whether diffusion tensor imaging can delineate the changes in optic radiations after lobectomy, we evaluated parameters on tensor images for optic radiations and correlated them with visual defect. METHODS: We examined 14 cases after temporal lobectomy. Durations after surgeries ranged from 3 weeks to 9 years. The cases were classified into three groups on the basis of the severity of visual field defect (A-C, with group C the most severe). We evaluated signals on T2-weighted images and parameters of tensor images, including fractional anisotropy (FA) and apparent diffusion coefficient (ADC), for the optic radiation in both the operated and intact side. RESULTS: On T2-weighted images, high signals in optic radiations were seen in four cases, occurring more than 4 weeks after surgery. The mean operated-to-intact side FA ratio in the optic radiation decreased according to severity of visual defect (group A, 0.88; group B, 0.89; group C, 0.73). The mean operated-to-intact side ADC ratio showed no significant difference in the overall cases. The ratio for ADC, however, tended to increase according to visual defect in cases after 10 weeks postsurgery. CONCLUSION: Optic radiation showed a decreased FA value in cases after temporal lobectomy. In later stages, ADC values tended to increase and high signal intensities on T2-weighted images were observed. The FA value can be used for evaluating Wallerian degeneration of optic radiation even in the early stages after surgery. © American Society of Neuroradiology.

Scopus

Proton MR spectroscopy of adult-onset dentatorubral-pallidoluysian atrophy

Kin T., Hirano M., Taoka T., Takamure M., Furiya Y., Kichikawa K., Ueno S.

Magnetic Resonance in Medical Sciences Vol. 4 ( 3 ) page： 123 - 127 2005.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Magnetic Resonance in Medical Sciences

Purpose: To quantify impairment of the basal ganglia (globus pallidus and thalamus) in adult-onset dentatorubral-pallidoluysian atrophy (DRPLA). Methods: Five patients with genetically definite adult-onset DRPLA (aged 51 to 65 years, mean 55.6 years) and 5 age- and sex-matched healthy controls underwent conventional magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (MRS) of the brain in the voxels predominantly containing the globus pallidus or the thalamus. Results: Conventional MRI studies showed apparently normal intensities in the globus pallidus and thalamus. MRS showed that the choline (Cho)/creatine (Cr) ratio for the patients' globus pallidus, the region preferentially affected in DRPLA, was significantly higher than that in the controls (p<0.05). The N-acetylaspartate (NAA)/Cr ratio for the globus pallidus and the Cho/Cr and NAA/Cr ratios for the thalamus, the region relatively spared in this disease, did not differ significantly between the patients and controls. Conclusions: MRS may sensitively and specifically detect biochemical alterations in susceptible regions of patients with adult-onset DRPLA.

DOI： 10.2463/mrms.4.123

Scopus

Ferucarbotran-enhanced perfusion MR imaging of the liver in patients with hypervascular hepatocellular carcinomas Reviewed

Shinji Hirohashi, Satoru Kitano, Toshiaki Taoka, Nagaaki Marugami, Kouji Ueda, Kimihiko Kichikawa

Academic Radiology Vol. 12 ( 5 ) page： S45 2005.5

Diffusion tensor imaging in cases with visual field defect after anterior temporal lobectomy International journal

T Taoka, M Sakamoto, S Iwasaki, H Nakagawa, A Fukusumi, S Hirohashi, K Taoka, K Kichikawa, T Hoshida, T Sakaki

AMERICAN JOURNAL OF NEURORADIOLOGY Vol. 26 ( 4 ) page： 797 - 803 2005.4

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER SOC NEURORADIOLOGY

BACKGROUND AND PURPOSE: Visual defect due to optic radiation injury is a complication of temporal lobectomy for temporal epilepsy. To investigate whether diffusion tensor imaging can delineate the changes in optic radiations after lobectomy, we evaluated parameters on tensor images for optic radiations and correlated them with visual defect.
METHODS: We examined 14 cases after temporal lobectomy. Durations after surgeries ranged from 3 weeks to 9 years. The cases were classified into three groups on the basis of the severity of visual field defect (A-C, with group C the most severe). We evaluated signals on T2-weighted images and parameters of tensor images, including fractional anisotropy (FA) and apparent diffusion coefficient (ADC), for the optic radiation in both the operated and intact side.
RESULTS: On T2-weighted images, high signals in optic radiations were seen in four cases, occurring more than 4 weeks after surgery. The mean operated-to-intact side FA ratio in the optic radiation decreased according to severity of visual defect (group A, 0.88; group B, 0.89; group C, 0.73). The mean operated-to-intact side ADC ratio showed no significant difference in the overall cases. The ratio for ADC, however, tended to increase according to visual defect in cases after 10 weeks postsurgery.
CONCLUSION. Optic radiation showed a decreased FA value in cases after temporal lobectomy. In later stages, ADC values tended to increase and high signal intensities on T2-weighted images were observed. The FA value can be used for evaluating Wallerian degeneration of optic radiation even in the early stages after surgery.

Web of Science

PubMed

Diffusion tensor imaging in cases with visual field defect after anterior temporal lobectomy Reviewed

T Taoka, M Sakamoto, S Iwasaki, H Nakagawa, A Fukusumi, S Hirohashi, K Taoka, K Kichikawa, T Hoshida, T Sakaki

AMERICAN JOURNAL OF NEURORADIOLOGY Vol. 26 ( 4 ) page： 797 - 803 2005.4

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER SOC NEURORADIOLOGY

BACKGROUND AND PURPOSE: Visual defect due to optic radiation injury is a complication of temporal lobectomy for temporal epilepsy. To investigate whether diffusion tensor imaging can delineate the changes in optic radiations after lobectomy, we evaluated parameters on tensor images for optic radiations and correlated them with visual defect.
METHODS: We examined 14 cases after temporal lobectomy. Durations after surgeries ranged from 3 weeks to 9 years. The cases were classified into three groups on the basis of the severity of visual field defect (A-C, with group C the most severe). We evaluated signals on T2-weighted images and parameters of tensor images, including fractional anisotropy (FA) and apparent diffusion coefficient (ADC), for the optic radiation in both the operated and intact side.
RESULTS: On T2-weighted images, high signals in optic radiations were seen in four cases, occurring more than 4 weeks after surgery. The mean operated-to-intact side FA ratio in the optic radiation decreased according to severity of visual defect (group A, 0.88; group B, 0.89; group C, 0.73). The mean operated-to-intact side ADC ratio showed no significant difference in the overall cases. The ratio for ADC, however, tended to increase according to visual defect in cases after 10 weeks postsurgery.
CONCLUSION. Optic radiation showed a decreased FA value in cases after temporal lobectomy. In later stages, ADC values tended to increase and high signal intensities on T2-weighted images were observed. The FA value can be used for evaluating Wallerian degeneration of optic radiation even in the early stages after surgery.

Web of Science

Evaluation of delayed image of 18F FDG-PET in diagnosis of pulmonary lesions

Sakamoto M., Imai T., Shingai T., Nishimoto Y., Taoka T., Koukawa K., Hirohashi S., Yoshimura H., Yoshikawa K.

Japanese Journal of Clinical Radiology Vol. 50 ( 1 ) page： 148 - 154 2005.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Clinical Radiology

We evaluated the usefulness of dual time point 18F-FDG PET by comparing two groups of pulmonary lesions (38 malignant tumors and 29 benign lesions). Among standardized uptake value (SUV) of early image (SUVe), SUV of delayed image (SUVd), Retention Index (RI), and SUVe combined with RI (SUVe-RI), diagnosis by SUVe-RI revealed the best result (sensitivity: 78.9%, specificity: 82.8%). We conclude that dual time point FDG-PET is better method than early or delayed single acquisition to diagnose pulmonary lesions.

Scopus

Evaluation of extraocular muscles using dynamic contrast enhanced MRI in patients with chronic thyroid orbitopathy.

Taoka T, Sakamoto M, Nakagawa H, Fukusumi A, Iwasaki S, Taoka K, Kichikawa K

Journal of computer assisted tomography Vol. 29 ( 1 ) page： 115 - 20 2005.1

Evaluation of extraocular muscles using dynamic contrast enhanced MRI in patients with chronic thyroid orbitopathy

Taoka T., Sakamoto M., Nakagawa H., Fukusumi A., Iwasaki S., Taoka K., Kichikawa K.

Journal of Computer Assisted Tomography Vol. 29 ( 1 ) page： 115 - 120 2005.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Computer Assisted Tomography

Objective: The purpose of the current study is to investigate the underlying pathophysiological changes of extraocular muscle (EOM) in Graves orbitopathy using dynamic contrast MR imaging and to correlate these MR functional changes with the anatomic abnormalities. Methods: EOMs of 16 patients with Graves disease and 12 normal volunteers were examined by dynamic enhanced MRI. We quantified the peak enhancement ratio of EOMs and calculated the ratio versus temporalis muscle and the ratio of maximum upslope versus temporalis muscle. We compared the ratios between normal volunteers and patient groups. Results: Mean of peak enhancement ratio values for the EOMs in patients with Graves disease tends to decrease according to the severity of the anatomic and clinical changes. The mean maximum upslope also decreased according to the severity of the disease for EOMs. Conclusion: Hemodynamic information obtained by dynamic contrast enhanced MRI is useful in evaluating the clinical course of thyroid orbitopathy.

DOI： 10.1097/01.rct.0000146112.56194.24

Scopus

Evaluation of extraocular muscles using dynamic contrast enhanced MRI in patients with chronic thyroid orbitopathy Reviewed

T Taoka, M Sakamoto, H Nakagawa, A Fukusumi, A Iwasaki, K Taoka, K Kichikawa

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY Vol. 29 ( 1 ) page： 115 - 120 2005.1

Language：English Publishing type：Research paper (scientific journal) Publisher：LIPPINCOTT WILLIAMS & WILKINS

Objective: The purpose of the current study is to investigate the underlying pathophysiological changes of extraocular muscle (EOM) in Graves orbitopathy using dynamic contrast MR imaging and to correlate these MR functional changes with the anatomic abnormalities.
Methods: EOMs of 16 patients with Graves disease and 12 normal volunteers were examined by dynamic enhanced MRI. We quantified the peak enhancement ratio of EOMs and calculated the ratio versus temporalis muscle and the ratio of maximum upslope versus temporalis muscle. We compared the ratios between normal volunteers and patient groups.
Results: Mean of peak enhancement ratio values for the EOMs in patients with Graves disease tends to decrease according to the severity of the anatomic and clinical changes. The mean maximum upslope also decreased according to the severity of the disease for EOMs.
Conclusion: Hemodynamic information obtained by dynamic contrast enhanced MRI is useful in evaluating the clinical course of thyroid orbitopathy.

DOI： 10.1097/01.rct.0000146112.56194.24

Web of Science

Proton MR spectroscopy of adult-onset dentatorubral-pallidoluysian atrophy

Tesseki Kin, Makito Hirano, Toshiaki Taoka, Miwa Takamure, Yoshiko Furiya, Kimihiko Kichikawa, Satoshi Ueno

Magnetic Resonance in Medical Sciences Vol. 4 ( 3 ) page： 123 - 7 2005

Language：English Publishing type：Research paper (scientific journal)

Purpose: To quantify impairment of the basal ganglia (globus pallidus and thalamus) in adult-onset dentatorubral-pallidoluysian atrophy (DRPLA). Methods: Five patients with genetically definite adult-onset DRPLA (aged 51 to 65 years, mean 55.6 years) and 5 age- and sex-matched healthy controls underwent conventional magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (MRS) of the brain in the voxels predominantly containing the globus pallidus or the thalamus. Results: Conventional MRI studies showed apparently normal intensities in the globus pallidus and thalamus. MRS showed that the choline (Cho)/creatine (Cr) ratio for the patients' globus pallidus, the region preferentially affected in DRPLA, was significantly higher than that in the controls (p&lt
0.05). The N-acetylaspartate (NAA)/Cr ratio for the globus pallidus and the Cho/Cr and NAA/Cr ratios for the thalamus, the region relatively spared in this disease, did not differ significantly between the patients and controls. Conclusions: MRS may sensitively and specifically detect biochemical alterations in susceptible regions of patients with adult-onset DRPLA.

DOI： 10.2463/mrms.4.123

Scopus

PubMed

Other Link： http://orcid.org/0000-0001-9227-0240

Proton MR Spectroscopy of Adult-onset Dentatorubral-pallidoluysian Atrophy

KIN Tesseki, HIRANO Makito, TAOKA Toshiaki, TAKAMURE Miwa, FURIYA Yoshiko, KICHIKAWA Kimihiko, UENO Satoshi

Magnetic Resonance in Medical Sciences Vol. 4 ( 3 ) page： 123 - 127 2005

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Magnetic Resonance in Medicine

Purpose: To quantify impairment of the basal ganglia (globus pallidus and thalamus) in adult-onset dentatorubral-pallidoluysian atrophy (DRPLA). Methods: Five patients with genetically definite adult-onset DRPLA (aged 51 to 65 years, mean 55.6 years) and 5 age- and sex-matched healthy controls underwent conventional magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (MRS) of the brain in the voxels predominantly containing the globus pallidus or the thalamus. Results: Conventional MRI studies showed apparently normal intensities in the globus pallidus and thalamus. MRS showed that the choline (Cho)/creatine (Cr) ratio for the patients' globus pallidus, the region preferentially affected in DRPLA, was significantly higher than that in the controls (p<0.05). The N-acetylaspartate (NAA)/Cr ratio for the globus pallidus and the Cho/Cr and NAA/Cr ratios for the thalamus, the region relatively spared in this disease, did not differ significantly between the patients and controls. Conclusions: MRS may sensitively and specifically detect biochemical alterations in susceptible regions of patients with adult-onset DRPLA.

DOI： 10.2463/mrms.4.123

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Papers - TAOKA Toshiaki