Updated on 2022/06/21

写真a

 
NAKAMURA Kazuhiro
 
Organization
Graduate School of Medicine Program in Integrated Medicine Cell Science Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor
Contact information
メールアドレス

Degree 2

  1. Ph.D. ( 2002.3   Kyoto University ) 

  2. 修士(薬学) ( 1999.3   京都大学 ) 

Research Interests 9

  1. Central neural circuit

  2. Thermoregulation

  3. Fever

  4. Stress

  5. Sympathetic nervous system

  6. Brown adipose tissue

  7. Metabolism

  8. Prostaglandin

  9. Emotion

Research Areas 2

  1. Life Science / Physiology  / Environmental physiology

  2. Life Science / Neuroscience-general  / Autonomic neuroscience

Current Research Project and SDGs 1

  1. Central circuitry mechanisms for integrative regulation of homeostatic functions

Research History 7

  1. Nagoya University   Graduate School of Medicine   Professor

    2015.4

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    Country:Japan

  2. Kyoto University   Career-Path Promotion Unit for Young Life Scientists   Associate professor

    2014.2 - 2015.3

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    Country:Japan

  3. PRESTO Researcher, JST

    2013.10 - 2017.3

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    Country:Japan

  4. Kyoto University   Career-Path Promotion Unit for Young Life Scientists   Lecturer

    2013.4 - 2014.1

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    Country:Japan

  5. Kyoto University   Career-Path Promotion Unit for Young Life Scientists   Designated assistant professor

    2009.4 - 2013.3

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    Country:Japan

  6. Postdoctoral Research Fellow, Oregon Health & Science University

    2005.4 - 2009.3

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    Country:United States

  7. Postdoctoral Fellow, JSPS

    2002.4 - 2005.3

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    Country:Japan

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Education 3

  1. Kyoto University   Graduate School of Pharmaceutical Sciences

    1999.4 - 2002.3

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    Country: Japan

  2. Kyoto University   Graduate School of Pharmaceutical Sciences

    1997.4 - 1999.3

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    Country: Japan

  3. Kyoto University   Faculty of Pharmaceutical Sciences

    1993.4 - 1997.3

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    Country: Japan

Professional Memberships 7

  1. 日本生理学会   理事・評議員

  2. American Physiological Society

  3. 日本神経科学学会

  4. Society for Neuroscience

  5. 日本自律神経学会   監事・評議員

  6. International Society for Autonomic Neuroscience

  7. 日本薬理学会

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Awards 12

  1. Award for Science and Technology (Research Category) as the Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology

    2021.4   Ministry of Education, Culture, Sports, Science and Technology  

    Kazuhiro Nakamura

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    Award type:International academic award (Japan or overseas)  Country:Japan

  2. JSPS-PRIZE

    2015.2   Japan Society for the Promotion of Science  

    Kazuhiro Nakamura

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    Country:Japan

  3. Japan Academy Medal Prize

    2015.2   The Japan Academy  

    Kazuhiro Nakamura

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    Country:Japan

  4. Henry Pickering Bowditch Award

    2014.4   American Physiological Society  

    Kazuhiro Nakamura

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    Award type:International academic award (Japan or overseas)  Country:United States

  5. Young Scientists' Award as the Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology

    2012.4   Ministry of Education, Culture, Sports, Science and Technology  

    Kazuhiro Nakamura

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    Country:Japan

  6. Annual Award for the Best Articles of Japan Society of Neurovegetative Research

    2013.10   Japan Society of Neurovegetative Research  

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    Country:Japan

  7. 日本生理学会 奨励賞

    2010.5   日本生理学会  

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    Country:Japan

  8. 日本生理学会 環境生理学グループ 久野 寧 記念賞

    2010.5   日本生理学会 環境生理学グループ  

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    Country:Japan

  9. Neural Control and Autonomic Regulation Section (NCAR) New Investigator Award

    2010.4   American Physiological Society (APS)  

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    Country:United States

  10. Festival of Lights Award

    2007   Neurological Sciences Institute at Oregon Health & Science University  

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    Country:United States

  11. Neural Control & Autonomic Regulation Research Recognition Award

    2005   American Physiological Society  

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    Country:United States

  12. 日本神経科学学会 奨励賞

    2005   日本神経科学学会  

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    Country:Japan

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Papers 88

  1. A hypothalamomedullary network for physiological responses to environmental stresses Reviewed International journal

    Nakamura, K., Nakamura, Y. & Kataoka, N.

    Nature Reviews Neuroscience   Vol. 23 ( 1 ) page: 35 - 52   2022.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41583-021-00532-x

    DOI: 10.1038/s41583-021-00532-x

  2. A central master driver of psychosocial stress responses in the rat Reviewed International journal

    Kataoka, N., Shima, Y., Nakajima, K. & Nakamura, K.

    SCIENCE   Vol. 367 ( 6482 ) page: 1105 - 1112   2020.3

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.aaz4639

    Web of Science

    PubMed

    Other Link: https://www.med.nagoya-u.ac.jp/physiol2/Paper-download.htm

  3. Central mechanisms for thermoregulation Invited Reviewed International coauthorship International journal

    Morrison, S.F. & Nakamura, K.

    Annual Review of Physiology   Vol. 81   page: 285 - 308   2019

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1146/annurev-physiol-020518-114546

    Web of Science

  4. The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation Reviewed International journal

    Yahiro, T., Kataoka, N., Nakamura, Y. & Nakamura, K.

    Scientific Reports   Vol. 7   page: 5031   2017.7

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-05327-8

    PubMed

  5. Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication Reviewed International coauthorship International journal

    Nakamura Y., Yanagawa Y., Morrison S.F. & Nakamura K.

    Cell Metabolism   Vol. 25 ( 2 ) page: 322 - 334   2017.1

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cmet.2016.12.002

    Scopus

  6. Psychological stress activates a dorsomedial hypothalamus-medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia Reviewed International journal

    Kataoka, N., Hioki, H., Kaneko, T. & Nakamura, K.

    Cell Metabolism   Vol. 20 ( 2 ) page: 346 - 358   2014.8

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cmet.2014.05.018

    PubMed

  7. Central circuitries for body temperature regulation and fever Invited Reviewed International journal

    K. Nakamura

    American Journal of Physiology - Regulatory Integrative and Comparative Physiology   Vol. 301 ( 5 ) page: R1207 - R1228   2011

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpregu.00109.2011

    PubMed

  8. A thermosensory pathway mediating heat-defense responses Reviewed International coauthorship International journal

    K. Nakamura; S.F. Morrison

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 107 ( 19 ) page: 8848 - 8853   2010.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.0913358107

  9. A thermosensory pathway that controls body temperature Reviewed International coauthorship International journal

    K. Nakamura; S.F. Morrison

    Nature Neuroscience   Vol. 11 ( 1 ) page: 62 - 71   2008

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nn2027

    PubMed

  10. Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions Reviewed International coauthorship International journal

    K. Nakamura; K. Matsumura; T. Hübschle; Y. Nakamura; H. Hioki; F. Fujiyama; Z. Boldogköi; M. König; H.-J. Thiel; R. Gerstberger; S. Kobayashi; T. Kaneko

    Journal of Neuroscience   Vol. 24 ( 23 ) page: 5370 - 5380   2004

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.1219-04.2004

    PubMed

  11. The Rostral Raphe Pallidus Nucleus Mediates Pyrogenic Transmission from the Preoptic Area Reviewed International journal

    K. Nakamura; K. Matsumura; T. Kaneko; S. Kobayashi; H. Katoh; M. Negishi

    Journal of Neuroscience   Vol. 22 ( 11 ) page: 4600 - 4610   2002.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  12. Central sympathetic network for thermoregulatory responses to psychological stress Invited Reviewed International coauthorship International journal

    Nakamura, K. & Morrison, S.F.

    AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL   Vol. 237   page: 102918   2022.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.autneu.2021.102918

  13. Where mind meets body: a master brain circuit for stress responses Invited Reviewed International journal

    Kataoka, N. & Nakamura, K.

    The Science Breaker     2020.10

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.25250/thescbr.brk404

  14. Hunger and Satiety Signaling: Modeling Two Hypothalamomedullary Pathways for Energy Homeostasis Invited Reviewed International journal

    Nakamura, K. & Nakamura, Y.

    BioEssays   Vol. 40 ( 8 ) page: e1700252   2018.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/bies.201700252

    Web of Science

    PubMed

  15. Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability Invited Reviewed International journal

    Nakamura, Y. & Nakamura, K.

    Pflügers Archiv - European Journal of Physiology   Vol. 470 ( 5 ) page: 823 - 837   2018.2

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00424-017-2090-z

    PubMed

  16. Afferent pathways for autonomic and shivering thermoeffectors Invited Reviewed International journal

    Nakamura Kazuhiro

    THERMOREGULATION: FROM BASIC NEUROSCIENCE TO CLINICAL NEUROLOGY, PT I   Vol. 156   page: 263 - 279   2018

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/B978-0-444-63912-7.00016-3

    Web of Science

    PubMed

  17. Neural circuit for psychological stress-induced hyperthermia Invited Reviewed International journal

    Nakamura K

    Temperature   Vol. 2   page: 352 - 361   2015.11

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/23328940.2015.1070944

  18. Distribution of Fos-immunoreactive cells in rat forebrain and midbrain following social defeat stress and diazepam treatment. Reviewed International journal

    Lkhagvasuren, B., Oka, T., Nakamura, Y., Hayashi, N., Sudo, N. & Nakamura, K.

    Neuroscience   Vol. 272   page: 34 - 57   2014.7

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuroscience.2014.04.047

  19. Central efferent pathways for cold-defensive and febrile shivering Reviewed International coauthorship International journal

    K. Nakamura; S.F. Morrison

    Journal of Physiology   Vol. 589 ( 14 ) page: 3641 - 3658   2011.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/jphysiol.2011.210047

    PubMed

  20. Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region Reviewed International journal

    B. Lkhagvasuren; Y. Nakamura; T. Oka; N. Sudo; K. Nakamura

    European Journal of Neuroscience   Vol. 34 ( 9 ) page: 1442 - 1452   2011

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1460-9568.2011.07863.x

  21. Central neural pathways for thermoregulation Invited Reviewed International coauthorship International journal

    S.F. Morrison; K. Nakamura

    Frontiers in Bioscience   Vol. 16 ( 1 ) page: 74 - 104   2011

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2741/3677

  22. Different populations of prostaglandin EP3 receptor-expressing preoptic neurons project to two fever-mediating sympathoexcitatory brain regions Reviewed International coauthorship International journal

    Y. Nakamura; K. Nakamura; S.F. Morrison

    Neuroscience   Vol. 161 ( 2 ) page: 614 - 620   2009

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuroscience.2009.03.041

  23. Preoptic mechanism for cold-defensive responses to skin cooling Reviewed International coauthorship International journal

    K. Nakamura; S.F. Morrison

    Journal of Physiology   Vol. 586 ( 10 ) page: 2611 - 2620   2008

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/jphysiol.2008.152686

  24. Central control of thermogenesis in mammals Invited Reviewed International coauthorship International journal

    S.F. Morrison; K. Nakamura; C.J. Madden

    Experimental Physiology   Vol. 93 ( 7 ) page: 773 - 797   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/expphysiol.2007.041848

  25. Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue Reviewed International coauthorship International journal

    K. Nakamura; S.F. Morrison

    American Journal of Physiology - Regulatory Integrative and Comparative Physiology   Vol. 292 ( 1 ) page: R127 - R136   2007

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpregu.00427.2006

  26. In vivo function of Rnd2 in the development of neocortical pyramidal neurons Reviewed International journal

    K. Nakamura; Y. Yamashita; N. Tamamaki; H. Katoh; T. Kaneko; M. Negishi

    Neuroscience Research   Vol. 54 ( 2 ) page: 149 - 153   2006.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  27. Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus Reviewed International coauthorship International journal

    Y. Nakamura; K. Nakamura; K. Matsumura; S. Kobayashi; T. Kaneko; S.F. Morrison

    European Journal of Neuroscience   Vol. 22 ( 12 ) page: 3137 - 3146   2005

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1460-9568.2005.04515.x

  28. Sympathetic premotor neurons mediating thermoregulatory functions Reviewed International journal

    K. Nakamura; K. Matsumura; S. Kobayashi; T. Kaneko

    Neuroscience Research   Vol. 51 ( 1 ) page: 1 - 8   2005

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  29. Independent inputs by VGLUT2- and VGLUT3-positive glutamatergic terminals onto rat sympathetic preganglionic neurons Reviewed International journal

    K. Nakamura; S.-X. Wu; F. Fujiyama; K. Okamoto; H. Hioki; T. Kaneko

    NeuroReport   Vol. 15 ( 3 ) page: 431 - 436   2004

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/00001756-200403010-00010

    PubMed

  30. Fever-inducing sympathetic neural pathways Invited Reviewed International journal

    K. Nakamura

    Journal of Thermal Biology   Vol. 29 ( 7-8 SPEC. ISS. ) page: 339 - 344   2004

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jtherbio.2004.08.001

  31. Neurons of the rat preoptic area and the raphe pallidus nucleus innervating the brown adipose tissue express the prostaglandin E receptor subtype EP3 Reviewed International coauthorship International journal

    K. Yoshida; K. Nakamura; K. Matsumura; K. Kanosue; M. König; H.-J. Thiel; Z. Boldogköi; I. Toth; J. Roth; R. Gerstberger; T. Hübschle

    European Journal of Neuroscience   Vol. 18 ( 7 ) page: 1848 - 1860   2003

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1460-9568.2003.02919.x

  32. Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: A double immunofluorescence study in the rat brain Reviewed International journal

    K. Nakamura; Y.-Q. Li; T. Kaneko; H. Katoh; M. Negishi

    Neuroscience   Vol. 103 ( 3 ) page: 763 - 775   2001

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0306-4522(01)00027-6

    PubMed

  33. Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system Reviewed International journal

    K. Nakamura; T. Kaneko; Y. Yamashita; H. Hasegawa; H. Katoh; M. Negishi

    Journal of Comparative Neurology   Vol. 421 ( 4 ) page: 543 - 569   2000.6

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/(SICI)1096-9861(20000612)421:4<543::AID-CNE6>3.0.CO;2-3

    PubMed

  34. Immunocytochemical localization of prostaglandin EP3 receptor in the rat hypothalamus Reviewed International journal

    K. Nakamura; T. Kaneko; Y. Yamashita; H. Hasegawa; H. Katoh; A. Ichikawa; M. Negishi

    Neuroscience Letters   Vol. 260 ( 2 ) page: 117 - 120   1999.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0304-3940(98)00962-8

    PubMed

  35. Inhibition of dopamine release by prostaglandin EP3 receptor via pertussis toxin-sensitive and -insensitive pathways in PC12 cells Reviewed International journal

    K. Nakamura; H. Katoh; A. Ichikawa; M. Negishi

    Journal of Neurochemistry   Vol. 71 ( 2 ) page: 646 - 652   1998.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1471-4159.1998.71020646.x

    PubMed

  36. Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity Reviewed International coauthorship International journal

    Yuka Hayashi, Ippei Shimizu, Yohko Yoshida, Ryutaro Ikegami, Masayoshi Suda, Goro Katsuumi, Shinya Fujiki, Kazuyuki Ozaki, Manabu Abe, Kenji Sakimura, Shujiro Okuda, Toshiya Hayano, Kazuhiro Nakamura, Kenneth Walsh, Naja Zenius Jespersen, Søren Nielsen, Camilla Scheele, Tohru Minamino

    iScience   Vol. 25 ( 7 ) page: 104547   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.isci.2022.104547

  37. Thermoregulation in mice: The road to understanding torpor hypothermia and the shortcomings of a circuit for generating fever Invited Reviewed International coauthorship International journal

    Morrison, S.F., Nakamura, K., Tupone, D.

    Temperature   Vol. 9 ( 1 ) page: 8 - 11   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/23328940.2021.2021059

    DOI: 10.1080/23328940.2021.2021059

  38. Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever Reviewed International coauthorship International journal

    Yoneshiro, T., Kataoka, N., Walejko, J. M., Ikeda, K., Brown, Z., Yoneshiro, M., Crown, S. B., Osawa, T., Sakai, J., McGarrah, R. W., White, P. J., Nakamura, K., & Kajimura, S.

    eLife   Vol. 10   page: e66865   2021.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.66865

    DOI: 10.7554/eLife.66865

    Web of Science

    PubMed

  39. microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity Reviewed International coauthorship International journal

    Horie, T., Nakao, T., Miyasaka, Y., Nishino, T., Matsumura, S., Nakazeki, F., Ide, Y., Kimura, M., Tsuji, S., Rodriguez, R.R., Watanabe, T., Yamasaki, T., Xu, S., Otani, C., Miyagawa, S., Matsushita, K., Sowa, N., Omori, A., Tanaka, J., Nishimura, C., Nishiga, M., Kuwabara, Y., Baba, O., Watanabe, S., Nishi, H., Nakashima, Y., Picciotto, M.R., Inoue, H., Watanabe, D., Nakamura, K., Sasaki, T., Kimura, T., & Ono, K.

    Nature Communications   Vol. 12 ( 1 ) page: 843   2021.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-021-21107-5

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  40. Combi-CRISPR: combination of NHEJ and HDR provides efficient and precise plasmid-based knock-ins in mice and rats Reviewed International journal

    Yoshimi, K., Oka, Y., Miyasaka, Y., Kotani, Y., Yasumura, M., Uno, Y., Hattori, K., Tanigawa, A., Sato, M., Oya, M., Nakamura, K., Matsushita, N., Kobayashi, K., & Mashimo, T.

    Human Genetics   Vol. 140 ( 2 ) page: 277 - 287   2021.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00439-020-02198-4

    Web of Science

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  41. Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior Reviewed International journal

    Ota, W., Nakane, Y., Kashio, M., Suzuki, Y., Nakamura, K., Mori, Y., Tominaga, M., & Yoshimura, T.

    Scientific Reports   Vol. 9 ( 1 ) page: 3706   2019.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-019-40067-x

    Web of Science

    Scopus

    PubMed

  42. Sympathoexcitation by hypothalamic paraventricular nucleus neurons projecting to the rostral ventrolateral medulla Reviewed International journal

    Koba, S., Hanai, E., Kumada, N., Kataoka, N., Nakamura, K., & Watanabe, T.

    Journal of Physiology   Vol. 596 ( 19 ) page: 4581 - 4595   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/JP276223

    Web of Science

    PubMed

  43. Differential inputs to the perisomatic and distal-dendritic compartments of VIP-positive neurons in layer 2/3 of the mouse barrel cortex Reviewed International journal

    Sohn J., Okamoto S., Kataoka N., Kaneko T., Nakamura K. & Hioki H.

    Frontiers in Neuroanatomy   Vol. 10   page: 124   2016.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fnana.2016.00124

  44. Dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, acutely reduces energy expenditure in BAT via neural signals in mice. Reviewed International journal

    Chiba, Y., Yamada, T., Tsukita, S., Takahashi, K., Munakata, Y., Shirai, Y., Kodama, S., Asai, Y., Sugisawa, T., Uno, K., Sawada, S., Imai, J., Nakamura, K. & Katagiri, H.

    PLoS One   Vol. 11   page: e0150756   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0150756

  45. Critical roles of nardilysin in the maintenance of body temperature homoeostasis Reviewed International journal

    Y. Hiraoka; T. Matsuoka; M. Ohno; K. Nakamura; S. Saijo; S. Matsumura; K. Nishi; J. Sakamoto; P.-M. Chen; K. Inoue; T. Fushiki; T. Kita; T. Kimura; E. Nishi

    Nature Communications   Vol. 5   page: 3224   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms4224

  46. Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon Reviewed International coauthorship International journal

    S. Wu; S. Esumi; K. Watanabe; J. Chen; K.C. Nakamura; K. Nakamura; K. Kometani; N. Minato; Y. Yanagawa; K. Akashi; K. Sakimura; T. Kaneko; N. Tamamaki

    Development   Vol. 138 ( 12 ) page: 2499 - 2509   2011.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1242/dev.063032

  47. EP<sub>3</sub> receptors mediate PGE<sub>2</sub>-induced hypothalamic paraventricular nucleus excitation and sympathetic activation Reviewed International coauthorship International journal

    Z.-H. Zhang; Y. Yu; S.-G. Wei; Y. Nakamura; K. Nakamura; R.B. Felder

    American Journal of Physiology - Heart and Circulatory Physiology   Vol. 301 ( 4 ) page: H1559 - H1569   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpheart.00262.2011

  48. The TRPV1 Channel in Normal Thermoregulation: What Have We Learned from Experiments Using Different Tools? Invited Reviewed International coauthorship International journal

    A. Garami; M.C. Almeida; T.B. Nucci; T. Hew-Butler; R.N. Soriano; E. Pakai; K. Nakamura; S.F. Morrison; A.A. Romanovsky

    Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders     page: 349 - 402   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/9780470588284.ch14

  49. Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease. Reviewed International coauthorship International journal

    Manczak M, Mao P, Nakamura K, Bebbington C, Park B & Reddy PH

    Human Molecular Genetics   Vol. 18 ( 20 ) page: 3876 - 3893   2009.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/hmg/ddp331

  50. Granulocyte-macrophage colony-stimulating factor antibody suppresses microglial activity: Implications for anti-inflammatory effects in Alzheimer's Disease and multiple sclerosis Reviewed International coauthorship International journal

    P. H. Reddy; M. Manczak; W. Zhao; K. Nakamura; C. Bebbington; G. Yarranton; P. Mao

    Journal of Neurochemistry   Vol. 111 ( 6 ) page: 1514 - 1528   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1471-4159.2009.06432.x

  51. The transient receptor potential vanilloid-1 channel in thermoregulation: A thermosensor it is not Reviewed International coauthorship International journal

    A.A. Romanovsky; M.C. Almeida; A. Garami; A.A. Steiner; M.H. Norman; S.F. Morrison; K. Nakamura; J.J. Burmeister; T.B. Nucci

    Pharmacological Reviews   Vol. 61 ( 3 ) page: 228 - 261   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/pr.109.001263

  52. Prostaglandin E<sub>2</sub> attenuates preoptic expression of GABA <sub>A</sub> receptors via EP3 receptors Reviewed International coauthorship International journal

    H. Tsuchiya; T. Oka; K. Nakamura; A. Ichikawa; C.B. Saper; Y. Sugimoto

    Journal of Biological Chemistry   Vol. 283 ( 16 ) page: 11064 - 11071   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M801359200

    PubMed

  53. Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone Reviewed International coauthorship International journal

    S.-X. Wu; S. Goebbels; K. Nakamura; K. Nakamura; K. Kometani; N. Minato; T. Kaneko; K.-A. Nave; N. Tamamaki

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 102 ( 47 ) page: 17172 - 17177   2005.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.0508560102

    PubMed

  54. Chemically specific circuit composed of vesicular glutamate transporter 3- and preprotachykinin B-producing interneurons in the rat neocortex Reviewed International coauthorship International journal

    H. Hioki; F. Fujiyama; K. Nakamura; S.-X. Wu; W. Matsuda; T. Kaneko

    Cerebral Cortex   Vol. 14 ( 11 ) page: 1266 - 1275   2004

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/cercor/bhh088

    PubMed

  55. Activation of EP4 receptors contributes to prostaglandin E2 mediated stimulation of renal sensory nerves Reviewed International coauthorship International journal

    Kopp, U.C., Cicha, M.Z., Nakamura, K., Nüsing, R.M., Smith, L.A. & Hökfelt, T.

    American Journal of Physiology-Renal Physiology   Vol. 287   page: F1269 - F1282   2004

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajprenal.00230.2004

  56. Developmental changes in expression of small GTPase RhoG mRNA in the rat brain Reviewed International journal

    Y. Ishikawa; H. Katoh; K. Nakamura; K. Mori; M. Negishi

    Molecular Brain Research   Vol. 106 ( 1-2 ) page: 145 - 150   2002.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0169-328X(02)00413-8

    PubMed

  57. Suppression of fever at near term is associated with reduced COX-2 protein expression in rat hypothalamus Reviewed International coauthorship International journal

    Mouihate, A., Clerget-Froidevaux, M.S., Nakamura, K., Negishi, M., Wallace, J.L. & Pittman, Q.J.

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   Vol. 283 ( 3 ) page: R800 - R805   2002.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpregu.00258.2002

  58. Gα<sub>12</sub> and Gα<sub>13</sub> inhibit Ca<sup>2+</sup>-dependent exocytosis through Rho/Rho- associated kinase-dependent pathway Reviewed International journal

    Y. Yamaguchi; H. Katoh; H. Yasui; J. Aoki; K. Nakamura; M. Negishi

    Journal of Neurochemistry   Vol. 75 ( 2 ) page: 708 - 717   2000.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1471-4159.2000.0750708.x

    PubMed

  59. Different membrane targeting of prostaglandin EP3 receptor isoforms dependent on their carboxy-terminal tail structures Reviewed International journal

    H. Hasegawa; H. Katoh; Y. Yamaguchi; K. Nakamura; S. Futakawa; M. Negishi

    FEBS Letters   Vol. 473 ( 1 ) page: 76 - 80   2000.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0014-5793(00)01508-8

    PubMed

  60. Molecular aspects of functions of prostaglandin E receptors in CNS Invited Reviewed International journal

    Negishi, M., Katoh, H., Nakamura, K., Aoki, J. & Fujita, H.

    Recent Res. Devel. Endocrinol.   Vol. 1   page: 133 - 143   2000

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    Language:English   Publishing type:Research paper (scientific journal)  

  61. Opposite regulation of transepithelial electrical resistance and paracellular permeability by Rho in Madin-Darby canine kidney cells Reviewed International journal

    H. Hasegawa; H. Fujita; H. Katoh; J. Aoki; K. Nakamura; A. Ichikawa; M. Negishi

    Journal of Biological Chemistry   Vol. 274 ( 30 ) page: 20982 - 20988   1999.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.274.30.20982

    PubMed

  62. Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: Requirement for two different tyrosine kinases Reviewed International journal

    J. Aoki; H. Katoh; H. Yasui; Y. Yamaguchi; K. Nakamura; H. Hasegawa; A. Ichikawa; M. Negishi

    Biochemical Journal   Vol. 340   page: 365 - 369   1999.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1042/0264-6021:3400365

    PubMed

  63. The key amino acid residue of prostaglandin EP3 receptor for governing G protein association and activation steps Reviewed International journal

    S. Satoh; C.-S. Chang; H. Katoh; H. Hasegawa; K. Nakamura; J. Aoki; H. Fujita; A. Ichikawa; M. Negishi

    Biochemical and Biophysical Research Communications   Vol. 255 ( 1 ) page: 164 - 168   1999.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1006/bbrc.1998.0161

    PubMed

  64. 心理ストレスによる褐色脂肪熱産生と体温上昇の中枢神経回路 Invited

    中村和弘

    医学のあゆみ   Vol. 280 ( 11 ) page: 1139 - 1143   2022.3

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  65. 環境ストレスに応じた体温調節の中枢神経ネットワーク Invited

    中村和弘

    Brain and Nerve   Vol. 74 ( 2 ) page: 143 - 150   2022.2

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  66. 心理ストレスによる体温上昇の中枢神経回路メカニズム Invited

    中村和弘

    Clinical Neuroscience   Vol. 39 ( 6 ) page: 724 - 726   2021.6

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  67. Central circuit mechanisms of sympathetic and behavioral responses to psychological stress Invited Reviewed

    Naoya Kataoka, Kazuhiro Nakamura

    The Autonomic Nervous System   Vol. 58 ( 1 ) page: 133 - 138   2021.4

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    Authorship:Last author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  68. 環境ストレスを生き抜くための体温の動的制御 Invited

    中村 和弘

    月刊「細胞」   Vol. 53 ( 4 ) page: 11 - 14   2021.3

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  69. 心理ストレス反応を駆動する大脳皮質から視床下部への心身相関メカニズム Invited

    片岡直也、中村和弘

    実験医学   Vol. 38 ( 14 ) page: 2367 - 2370   2020.8

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  70. ストレス性体温上昇の神経機序-感染性発熱との比較から- Invited

    中村和弘

    心身医学   Vol. 60 ( 3 ) page: 203 - 209   2020.4

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.15064/jjpm.60.3_203

  71. 睡眠と体温調節能の老化変容における視床下部神経回路の役割 Invited Reviewed

    佐藤亜希子、中村和弘

    基礎老化研究   Vol. 43 ( 3 ) page: 23 - 28   2019.10

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    Authorship:Last author   Language:Japanese  

  72. 飢餓から生命を守るための脳の仕組み Invited

    中村和弘、中村佳子

    脳神経内科   Vol. 90 ( 6 ) page: 618 - 626   2019.6

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    Authorship:Lead author, Corresponding author   Language:Japanese  

  73. 多様な環境ストレスに応じた褐色脂肪熱産生調節の中枢メカニズム Invited Reviewed

    中村和弘

    生化学   Vol. 90 ( 3 ) page: 408 - 412   2018.6

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.14952/SEIKAGAKU.2018.900408

  74. 体温調節の行動とその神経回路メカニズム-快適な温度環境を選ぶための温度感覚とは? Invited

    中村和弘

    CLINICAL CALCIUM   Vol. 28 ( 1 ) page: 65 - 72   2018.1

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  75. 飢餓反応の中枢神経回路メカニズム Invited

    中村和弘、中村佳子

    肥満研究   Vol. 23 ( 2 ) page: 161 - 168   2017.9

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    Authorship:Lead author, Corresponding author   Language:Japanese  

  76. 体温を調節する中枢神経回路メカニズム Invited

    中村 和弘

    日本神経精神薬理学雑誌   Vol. 36   page: 93 - 99   2016.8

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese  

  77. 体温・代謝調節システムの研究から「温度生物学」への展開 Invited Reviewed

    中村 和弘

    生物物理   Vol. 56   page: 149 - 153   2016.5

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese  

    DOI: 10.2142/biophys.56.149

  78. Central circuit mechanism for psychological stress-induced hyperthermia Invited

    Nakamura, K.

    BRAIN and NERVE   Vol. 67 ( 10 ) page: 1205 - 1214   2015.10

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  79. 体温調節機構とその異常 Invited

    中村和弘

    Clinical Neuroscience   Vol. 32 ( 12 ) page: 1387 - 1390   2014.12

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  80. 体温調節に必要な環境温度情報の神経伝達機構 Invited Reviewed

    中村和弘

    自律神経   Vol. 51   page: 91 - 98   2014.6

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  81. 神経による褐色脂肪の機能調節 Invited

    中村和弘

    The Lipid   Vol. 25   page: 36 - 42   2014

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  82. 褐色脂肪熱産生を調節する中枢神経機構ー寒冷、感染、ストレスを生き抜くために Invited

    中村和弘

    医学のあゆみ   Vol. 242 ( 12 ) page: 913 - 917   2012.9

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  83. [Central neuronal mechanism for body temperature regulation]. Invited

    K. Nakamura

    Nihon rinsho. Japanese journal of clinical medicine   Vol. 70 ( 6 ) page: 922 - 926   2012

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    PubMed

  84. 褐色脂肪組織熱産生の中枢神経調節メカニズム Invited

    中村和弘

    肥満研究   Vol. 17 ( 2 ) page: 87 - 95   2011.8

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  85. 視床下部からの交感神経遠心路 Invited

    中村和弘

    分子精神医学   Vol. 11 ( 1 ) page: 23 - 29   2011.1

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  86. 体温調節のメカニズム Invited Reviewed

    中村和弘

    自律神経   Vol. 47 ( 4 ) page: 281 - 286   2010.8

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  87. 体温調節の中枢神経回路メカニズム Invited

    中村和弘

    生体の科学   Vol. 61 ( 3 ) page: 276 - 285   2010.5

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  88. 発熱及び体温調節の交感神経経路 Invited

    中村和弘

    自律神経   Vol. 43 ( 1 ) page: 44 - 51   2006.2

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

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Books 15

  1. 自律神経:初めて学ぶ方のためのマニュアル(榊原隆次、内田さえ 編著)

    中村和弘( Role: Contributor ,  II章–6. 体温の調節機構)

    中外医学社  2022.4  ( ISBN:978-4-498-32880-8

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    Total pages:444   Responsible for pages:125–133   Language:Japanese Book type:Scholarly book

  2. Efficient labeling of neurons and identification of postsynaptic sites using adeno-associated virus vector. In: Receptor and Ion Channel Detection in the Brain (2nd Ed)., ed. by Lujan R. and Ciruela F. Reviewed

    Takahashi, M., Ishida, Y., Kataoka, N., Nakamura, K., Hioki, H.( Role: Contributor ,  Neuromethods Vol. 169, Pages 323–341)

    Humana, New York, NY.  2021.7 

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    Responsible for pages:323–341   Language:English Book type:Scholarly book

    DOI: 10.1007/978-1-0716-1522-5_22

  3. Annual Review 神経 2021(鈴木則宏、荒木信夫、宇川義一 、桑原 聡、塩川芳昭 編集)

    中村和弘( Role: Contributor ,  多様な心理ストレス反応を制御する脳神経回路:心身相関メカニズムの理解へ)

    中外医学社  2021.6  ( ISBN:978-4-498-32870-9

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    Total pages:367   Responsible for pages:329–336   Language:Japanese Book type:Scholarly book

  4. 実験医学増刊号「臓器連環による生体恒常性の破綻と疾患」(春日雅人 編集)

    中村和弘( Role: Contributor)

    羊土社  2019.4 

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    Language:Japanese Book type:Scholarly book

  5. Chapter 16 - Afferent pathways for autonomic and shivering thermoeffectors. In: Handbook of Clinical Neurology (Thermoregulation: From Basic Neuroscience to Clinical Neurology Part I)

    Kazuhiro Nakamura( Role: Joint author)

    Elsevier  2018.11 

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    Language:English Book type:Scholarly book

  6. ガイトン生理学 原著第13版(石川義弘・岡村康司・尾仲達史・河野憲二 総監訳)

    中村和弘( Role: Joint translator ,  第73章 エネルギー論と代謝速度、第74章 体温調節と発熱)

    エルゼビア  2018.3  ( ISBN:9784860347741

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    Total pages:1100   Language:Japanese Book type:Textbook, survey, introduction

  7. ブレインサイエンス・レビュー 2017(廣川信隆 編)

    中村和弘( Role: Contributor ,  心理ストレスによる自律生理反応を駆動する中枢神経回路機構)

    クバプロ  2017.2 

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    Total pages:308   Language:Japanese

  8. コメディカル専門基礎科目シリーズ 生理学( 桑名俊一・荒田晶子 編著)

    中村 和弘( Role: Sole author ,  第15章 体温の調節)

    理工図書  2016.8  ( ISBN:978-4-8446-0848-6

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    Language:Japanese Book type:Textbook, survey, introduction

  9. Annual Review 2016 糖尿病・代謝・内分泌(寺内康夫、伊藤 裕、石橋 俊 編)

    中村 和弘( Role: Sole author ,  体温の中枢制御機構)

    中外医学社  2016.1  ( ISBN:978-4-498-12366-3

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    Language:Japanese Book type:Scholarly book

  10. オックスフォード・生理学 原書4版( 岡野栄之・鯉淵典之・植村慶一 監訳)

    樋口 隆、中村和弘( Role: Joint translator ,  第39章 体温調節)

    丸善  2016.1  ( ISBN:978-4-621-30008-4

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    Language:Japanese Book type:Textbook, survey, introduction

  11. 糖尿病学2015(門脇 孝 編)

    中村 和弘( Role: Sole author)

    診断と治療社  2015.5  ( ISBN:9784787821737

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    Language:Japanese

  12. リッピンコットシリーズ イラストレイテッド生理学(鯉渕典之、栗原 敏 監訳)

    中村 和弘( Role: Sole author)

    丸善  2014.12  ( ISBN:978-4-621-08800-5

  13. ここまでわかった 燃える褐色脂肪の不思議(斉藤昌之、大野秀樹 編)

    中村 和弘( Role: Sole author)

    ナップ  2013.6  ( ISBN:978-4-905168-25-6

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    Language:Japanese

  14. Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

    Garami, A., Almeida, M.C., Nucci, T.B., Hew-Butler, T., Soriano, R.N., Pakai, E., Nakamura, K., Morrison, S.F. & Romanovsky, A.A.( Role: Joint author)

    John Wiley & Sons  2010 

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    Language:English

  15. これだけは知っておきたいアラキドン酸カスケードQ&A(室田誠逸 編)

    中村和弘( Role: Sole author)

    医薬ジャーナル社  2002 

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Presentations 59

  1. Thermal physiology research in Nagoya University Invited

    Kazuhiro Nakamura

    2022.3.16 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  2. Perspectives on psychosomatic research Invited

    Naoya Kataoka, Kazuhiro Nakamura

    2022.3.16 

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    Event date: 2022.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  3. Central psychosomatic neural pathway driving stress responses Invited International conference

    Nakamura, K.

    Integrative control of physiological responses by neuropeptides  2021.10.30 

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    Event date: 2021.10

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Nara, Japan   Country:Japan  

  4. 多様な環境ストレスから生命を守る脳の交感神経制御メカニズム(特別講演) Invited

    中村和弘

    第74回日本自律神経学会総会  2021.10.24 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  5. 心理的ストレス性交感神経反応および行動の中枢神経メカニズム Invited International conference

    片岡直也、嶋 佑太、中村和弘

    第44回日本神経科学大会・CJK第1回国際会議  2021.7.28 

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    Event date: 2021.7

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

  6. 交感神経を制御する脳の神経回路:多様な環境ストレスから生命を守るために(教育講演) Invited International conference

    中村和弘

    第44回日本神経科学大会・CJK第1回国際会議  2021.7.29 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  7. 哺乳類の体温調節機構 Invited

    中村和弘

    第58回日本伝熱シンポジウム  2021.5.25 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  8. Central neural mechanisms of multi-organ responses to psychological stress: a mind-body connection Invited

    中村和弘

    第64回日本糖尿病学会年次学術集会  2021.5.22 

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    Event date: 2021.5

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

  9. How do emotions impact thermogenic and cardiovascular functions? Invited

    Kazuhiro Nakamura, Naoya Kataoka, Akihiro Fukushima

    The 126th Annual Meeting of the Japanese Association of Anatomists / The 98th Annual Meeting of the Physiological Society of Japan  2021.3.28 

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    Event date: 2021.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

  10. Oxytocinergic pathway stimulating brown adipose tissue thermogenesis Invited

    Akihiro Fukushima, Kazuhiro Nakamura

    The 126th Annual Meeting of the Japanese Association of Anatomists / The 98th Annual Meeting of the Physiological Society of Japan  2021.3.29 

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    Event date: 2021.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

  11. 脳による褐色脂肪熱産生制御:心と脂肪をつなぐ神経回路 Invited

    中村和弘

    第41回日本肥満学会・第38回日本肥満症治療学会学術集会  2021.3.21 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  12. 飢餓反応の中枢神経回路メカニズム Invited

    中村佳子、中村和弘

    大阪大学蛋白質研究所セミナー「食行動の脳内基盤と分子機構」  2021.2.22 

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    Event date: 2021.2

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  13. 心理ストレスによる交感神経反応の中枢神経メカニズム ~心身相関の解明に向けて~ Invited

    中村和弘.

    第20回自律神経懇話会 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋市(Web開催)   Country:Japan  

  14. A central psychosomatic neural pathway that drives sympathetic and behavioral stress responses Invited International conference

    Nakamura, K.

    virtual 8th International Conference on the Physiology and Pharmacology of Temperature Regulation (vPPTR) 2020 

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    Event date: 2020.10

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:online meeting hosted from North Vancouver, Canada   Country:Canada  

  15. 心理ストレス反応の神経回路 —「心」と「体」をつなぐ仕組み — Invited

    中村和弘.

    令和2年度生理学研究所研究会「生体システム統合機構としての情動」(情動研究会) 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:愛知県岡崎市(Web開催)   Country:Japan  

  16. Central neural pathways for thermosensory information to promote heat loss responses and heat avoidance behavior Invited

    Kazuhiro Nakamura

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    Event date: 2020.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  17. Central circuit mechanisms of sympathetic and behavioral responses to psychological stress Invited

    Naoya Kataoka, Yuta Shima, Kazuhiro Nakamura

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    Event date: 2020.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Beppu, Oita (online meeting)   Country:Japan  

  18. Central neural mechanisms to defend life from environmental stressors Invited International conference

    Nakamura, K.

    Visiting Fellows Lecture of the Institute of Advanced Studies at University of Bologna 

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    Event date: 2019.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Bologna, Italy   Country:Italy  

  19. Central circuit for physiological responses to psychological stress Invited International conference

    Nakamura, K.

    Seminar in the Department of Physiology at University of Bologna 

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    Event date: 2019.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Bologna, Italy   Country:Italy  

  20. 心理ストレス性交感神経反応を制御する脳神経経路の同定 Invited

    片岡直也、嶋 佑太、中島啓輔、中村和弘

    第72回日本自律神経学会総会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:福岡県北九州市   Country:Japan  

  21. Mechanisms of psychological impacts on thermoregulation and metabolism Invited International conference

    Nakamura, K.

    The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)/The 96th Annual Meeting of the Physiological Society of Japan 

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    Event date: 2019.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  22. 環境ストレスから恒常性を守る体温調節神経回路(教育講演) Invited

    中村和弘

    第71回日本自律神経学会総会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:さいたま市   Country:Japan  

  23. Thermosensory afferent neural pathways for autonomous and behavioral thermoregulation (Organizer, Chair, Symposium Speaker) Invited International conference

    Nakamura, K.

    7th International Meeting of the Physiology and Pharmacology of Temperature Regulation (PPTR2018) 

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    Event date: 2018.10

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Split, Croatia   Country:Japan  

  24. 行動性・自律性体温調節の中枢神経メカニズム(基調講演) Invited

    中村和弘

    第56回快適性・健康を考えるシンポジウム 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:京都市   Country:Japan  

  25. Central thermoregulatory circuits to defend homeostasis from environmental stressors (Invited Speaker) Invited International conference

    Nakamura, K.

    Mini-Symposium on Temperature and Metabolism 

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    Event date: 2018.8

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Shanghai, China   Country:Japan  

  26. 環境ストレスに応じた褐色脂肪熱産生制御を行う脳の神経回路(シンポジスト) Invited

    中村和弘

    第23回アディポサイエンスシンポジウム 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:大阪府豊中市   Country:Japan  

  27. Central circuit mechanisms of infection-induced and psychogenic fever: What's different? (Symposium Speaker) Invited

    Nakamura, K.

    41st Annual Meeting of Japan Neuroscience Society 

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    Event date: 2018.7

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  28. 脳による代謝熱産生の調節(セミナー講演) Invited

    中村和弘

    第48回新潟神経学夏期セミナー 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:新潟市   Country:Japan  

  29. 心理ストレスによる体温上昇の仕組み(座長・シンポジスト) Invited

    中村和弘、片岡直也

    第65回日本実験動物学会総会 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:富山市   Country:Japan  

  30. 温度知覚と体温調節行動は異なる温度感覚伝達路で駆動される(オーガナイザー・座長・シンポジスト) Invited

    中村和弘、八尋貴樹、片岡直也、中村佳子

    第95回日本生理学会大会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:高松市   Country:Japan  

  31. 温熱恒常性の神経回路メカニズム(オーガナイザー・座長・シンポジスト) Invited

    中村和弘

    生命科学系学会合同年次大会(ConBio2017) 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:神戸市   Country:Japan  

  32. ニューロペプチドYによる熱産生抑制と摂食亢進の神経メカニズム(ワークショップ演者) Invited

    中村佳子、中村和弘

    生命科学系学会合同年次大会(ConBio2017) 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:神戸市   Country:Japan  

  33. 心理ストレスによる交感神経反応の中枢神経回路メカニズム(ワークショップ演者) Invited

    中村和弘、片岡直也

    第58回 日本組織細胞化学会 総会・学術集会 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  34. Central Neural Mechanisms to Defend Life from Environmental Stressors (Invited speaker) Invited

    Nakamura, K.

    Thermal Biology 2017 International Symposium 

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    Event date: 2017.9

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Kyoto, Japan   Country:Japan  

  35. Difference in central circuit mechanisms of infection-induced and psychogenic fever (Symposium speaker) Invited International conference

    Nakamura, K.

    International Society for Autonomic Neuroscience (ISAN) 2017 

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    Event date: 2017.8 - 2017.9

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Nagoya, Japan   Country:Japan  

  36. 体温調節の中枢神経回路メカニズム(シンポジスト) Invited

    中村和弘

    第25回 日本発汗学会 総会 

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    Event date: 2017.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:埼玉県川越市   Country:Japan  

  37. Medullary reticular GABAergic neurons that mediate hunger responses induced by hypothalamic neuropeptide Y ("Featured Topic" speaker) Invited International conference

    Nakamura, Y., Yanagawa, Y., Morrison S.F., Nakamura, K.

    Experimental Biology 2017 

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    Event date: 2017.4

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Chicago, IL, U.S.A.   Country:United States  

  38. 体温を調節する脳の神経回路メカニズム(招待講演) Invited

    中村和弘

    三重県栄養士会 平成28年度研究発表会・研修会 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  39. Higher brain stress signalling that drives the hypothalamo-medullary pathway for stress-induced hyperthermia (Symposist) Invited International conference

    Nakamura K., Kataoka N.

    6th International Conference on the Physiology and Pharmacology of Temperature Regulation (PPTR2016) 

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    Event date: 2016.12

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Slovenia   Country:Japan  

  40. 環境ストレスに応じた褐色脂肪熱産生の調節(シンポジスト) Invited

    中村和弘

    第39回日本分子生物学会年会 

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    Event date: 2016.11 - 2016.12

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:横浜   Country:Japan  

  41. 体温と代謝を調節する中枢神経回路機構(シンポジスト) Invited

    中村和弘

    第89回日本生化学会大会 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:仙台   Country:Japan  

  42. Central pathways for cold-induced thermogenesis Invited International conference

    Kazuhiro Nakamura

    The Wenner-Gren Foundations International Symposium "Brown adipose tissue and euthermia" 

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    Event date: 2016.5

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Stockholm, Sweden   Country:Sweden  

  43. 環境ストレスから生命を守る体温調節神経回路(特別講演) Invited

    中村 和弘

    第15回KAMOGAWA Cardiovascular Conference 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  44. 体温調節の神経機構(教育講演) Invited

    中村 和弘

    第93回日本生理学会大会 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  45. 多様な環境ストレスから生命を守る神経回路システム 〜体温調節研究を通じて〜(シンポジウム) Invited

    中村 和弘

    自然科学研究機構 3プロジェクト合同終了シンポジウム「次ステージ機能生命科学の展望」 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  46. 光遺伝学を用いたストレス性体温上昇メカニズムの解明(招待講演) Invited

    中村 和弘

    千里ライフサイエンスセミナー 

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    Event date: 2016.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  47. 体温調節の神経回路 〜環境ストレスから身を守るための仕組み〜(招待講演) Invited

    中村 和弘

    名古屋内科医会 第77回学術の集い 

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    Event date: 2016.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  48. 体温を調節する中枢神経回路メカニズム Invited

    中村 和弘

    第60回脳の医学・生物学研究会 

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    Event date: 2016.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  49. Central hunger signaling that inhibits brown adipose tissue thermogenesis Invited International conference

    Kazuhiro Nakamura

    Kyoto Conference of Young Lions in Obesity Research 

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    Event date: 2015.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  50. Cold-defense neural pathway drives stress-induced hyperthermia Invited International conference

    Kazuhiro Nakamura

    International Society for Autonomic Neuroscience 2015 

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    Event date: 2015.9

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Italy  

  51. 体温調節、発熱、ストレス性高体温症の中枢神経回路(招待講演)

    中村和弘

    第6回 Advanced Biological Chemistry Seminar(京都大学大学院工学研究科 先端生物化学セミナー) 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:京都大学   Country:Japan  

  52. 環境ストレスから生命を守る体温調節システム(招待講演)

    中村和弘

    第8回ラットリソースリサーチ研究会 

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    Event date: 2015.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:京都   Country:Japan  

  53. 褐色脂肪熱産生を調節する中枢神経システム〜環境ストレスを生き抜くために〜(招請講演)

    中村和弘

    第4回Metabolism Scientific Forum 

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    Event date: 2014.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  54. 体温調節の中枢神経回路〜多様な環境ストレスを生き抜くために〜(特別講演)

    中村和弘

    17th Cardiovascular Metabolism and Aging Conference 

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    Event date: 2014.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  55. Central thermoregulatory system: a mechanism that defends life from various environmental stressors (Henry Pickering Bowditch Award Lecture) International conference

    Kazuhiro Nakamura

    Experimental Biology 2014 

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    Event date: 2014.4

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:United States  

  56. 体温調節の仕組み(特別講演)

    中村和弘

    第18回東北生活習慣病研究会 

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    Event date: 2014.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  57. A thermosensory pathway mediating heat-defense responses(日本自律神経学会賞受賞記念講演)

    中村和弘

    第66回日本自律神経学会総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  58. 体温調節のメカニズム(教育講演)

    中村和弘

    第62回日本自律神経学会総会 

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    Event date: 2009.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  59. 体温調節の中枢メカニズム(招待講演)

    中村和弘

    日本麻酔科学会第56回学術集会 

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    Event date: 2009.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 4

  1. 中枢における情動—自律神経連関の神経回路解明とその制御法の開発

    Grant number:JPMJMS2023-12  2020.12

    ムーンショット型研究開発事業  恒常性の理解と制御による糖尿病および併発疾患の克服

    中村和弘

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    Authorship:Principal investigator  Grant type:Competitive

  2. 個体・臓器老化研究拠点

    Grant number:21gm5010002s0305  2017.10 - 2022.3

    日本医療研究開発機構  老化メカニズムの解明・制御プロジェクト 

    中村和弘

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  3. 脳と末梢器官の新たな恒常性維持クロストーク機構の解明

    2013.10 - 2017.3

    さきがけ 「生体における動的恒常性維持・変容機構の解明と制御」領域 

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    Grant type:Competitive

  4. ストレス疾患克服に向けた情動—自律連関の脳神経回路メカニズムの解明

    2011.2 - 2014.3

    最先端・次世代研究開発支援プログラム 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 14

  1. Corticolimbic circuits that processing psychological stress signals

    Grant number:20H03418  2020.4 - 2023.3

    JSPS  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Kazuhiro Nakamura

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\17680000 ( Direct Cost: \13600000 、 Indirect Cost:\4080000 )

  2. オキシトシン神経活動操作技術を用いたストレス神経回路機構の解析

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(B)

    中村 和弘

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    Authorship:Principal investigator 

  3. 体温と代謝の自律性・行動性調節を担う神経回路機構の解明

    2015.6 - 2020.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  4. 温度生物学の国際研究展開

    2015.11 - 2020.3

    科学研究費補助金 

    富永 真琴

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    Authorship:Coinvestigator(s) 

  5. オキシトシンニューロン光操作技術を用いた共感性と自律生理反応の中枢神経基盤の解明

    2014.4 - 2016.3

    科学研究費補助金  新学術領域研究(研究領域提案型)公募研究

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    Authorship:Principal investigator 

  6. ストレス性自律生理反応を担う中枢神経伝達

    2014.4 - 2016.3

    科学研究費補助金  若手研究(A)

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    Authorship:Principal investigator 

  7. ストレス性自律生理反応の神経科学的基盤の解明

    2010.4 - 2011.3

    科学研究費補助金  若手研究(A)

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    Authorship:Principal investigator 

  8. ストレス性自律生理反応の神経科学的基盤

    2009

    科学研究費補助金 

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    Authorship:Principal investigator 

  9. 自律性機能の統合的制御を実現する中枢神経機構の解明

    2006.4 - 2008.3

    科学研究費補助金  海外特別研究員

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    Authorship:Principal investigator 

  10. プロスタグランジンE2による生理作用の発現機構に関する神経科学的研究

    2002.4 - 2005.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  11. プロスタグランジンE2による神経伝達の調節機構に関する研究

    1999.4 - 2002.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  12. Analysis of stress neural circuits using oxytocin neuron-selective activity manipulation

    Grant number:16H05128  2016.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Nakamura Kazuhiro, NAKAMURA Yoshiko, KATAOKA Naoya, FUKUSHIMA Akihiro

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    Authorship:Principal investigator 

    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

    I studied how oxytocin, a neuropeptide often called the “love hormone”, acts in the brain to affect autonomic physiological functions, such as body temperature regulation and stress-coping responses. By employing in vivo optogenetic techniques to selectively stimulate a group of oxytocin neurons in the hypothalamus together with other anatomical and physiological techniques, I identified an oxytocinergic neuronal pathway that stimulates brown adipose tissue thermogenesis and tachycardia.

  13. 温度生物学の国際研究展開

    Grant number:15K21744  2015.11 - 2021.3

    科学研究費助成事業  新学術領域研究(研究領域提案型)

    富永 真琴, 今本 尚子, 梅田 真郷, 原田 慶恵, 中村 和弘, 土居 雅夫, 南 雅文, 高木 昌宏, 久原 篤, 岡部 弘基, 山田 哲也, 柴崎 貢志

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    Authorship:Coinvestigator(s) 

    1) 温度感受性TRPV2チャネルのメチオニン残基が過酸化水素で酸化されて機能増強を起こすことを明らかにした。(富永)2) 脂質膜の挙動とダイナミクスは物理的および化学的な外部刺激によって影響を受けるが、浸透圧が膜相分離構造に与える影響に着目し、線張力の変化について詳細な検討を行った。(高木)3) シンプルな実験動物を使い個体の温度応答に関わる新規の分子としてKCNQ型カリウムチャネルの生理的動態の解析を進めた。(久原)4) Hikeshiの機能が損なわれたために起こるHsp70の核内喪失の影響と、Hikeshi輸送が駆動するメカニズムを明らかにした。(今本)5) 細胞膜の物性および膜脂質の分子動態の評価方法を確立した。(梅田)6) 蛍光性ナノダイヤモンド(FND)を用いて、細胞内の熱生産や熱感知のメカニズムを明らかにした。(原田)7) 小胞体の構造と機能に異常が生じる疾患モデル細胞における細胞内温度計測・熱特性解析を実施し、小胞体の構造に起因する細胞内温度変化を発見した。(岡部)8) 睡眠メカニズムと熱産生メカニズムの解明を試みた。(中村)9) 臓器連関が、褐色脂肪組織の熱産生の低下を引き起こし、体重の減少を最小限にとどめる生理的な機構であることを明らかにした。(山田)10) 新たな体温の日内制御機構を明らかにした。(土居)11) 自由行動中のin vivo電気生理学実験の手術や行動実験を学んで研究室に導入した。(南)12) 細胞が浮腫を起こした際に、体温にプラスして細胞容積増大に伴う膜伸展刺激が生じることでTRPV4の異常活性化が惹起することを見いだした。(柴崎)
    1) 温度感受性TRPV4チャネルがATP放出からadenosine, B2受容体を介して食道上皮細胞のwound healingを抑制することを明らかにした。(富永)2) 相挙動に対する浸透圧の影響を、蛍光顕微鏡により異なる温度で定量的に調べて詳細な相図を作製し、張力が相分離の温度特性に関係することを明らかにしつつある。 さらに、浸透圧が誘起する相分離の物理化学的メカニズムを説明することが分かった。(高木)3) 神経系における温度情報伝達に関わる新規の分子としてKCNQ型カリウムチャネルの生理的動態の解析をすすめ学会発表した。(久原)4) HikeshiとHsp70は、HikeshiのN末領域に存在する疎水ポケットと相互作用する核膜孔複合体構成因子存在下で温度依存的に結合することが示唆された。(今本)5) 確立した評価方法を用いた解析により、膜物性と膜動態の新規な制御機構を明らかにしつつある。(梅田)6) 発熱特性を有するポリマーでFNDの表面を修飾することよって、発熱と温度計測を同時に達成できるナノシステムを開発し、細胞内局所の熱伝導率が水と異なることを実験的に明らかにした。(原田)7) 睡眠、体温、ストレスをつなぐ神経回路に関する共同実験を行った。また、米国・UCSFと熱産生機能に関する実験データをまとめた。(中村)8) 飢餓時に肝臓から分泌される液性因子が、褐色脂肪の熱産生低下を引き起こす臓器連関に関与していることが明らかになった。(山田)9) 体温下での細胞容積増大に伴うTRPV4異常活性化の分子機構を解析中である。(柴崎)
    以上のように積極的に国際共同研究を進めてきたが、実験機器の調整に手間取って計画実行に遅れが生じた。また、新たな発見があって、追加実験が必要になった。
    1) マギル大学、中国西交利物浦大学、韓国KIT、Omanスルタンカブース大学等との共同研究をさらに推進する。(富永)2) 負電荷脂質を含んだ細胞模倣膜(リポソーム)を用いて、浸透圧をはじめとする物理的刺激、生理活性物質等による化学的刺激が、膜相分離構造、特に線張力に与える影響を調べる。(高木)3) 温度受容に関わる新規の分子の培養細胞などにおける生理学的解析を進める。(久原)4) Hikeshiの疎水ポケットに点変異があると蛋白質が不安定になる。その点変異でヒト遺伝子疾患白質髄質症が誘引されるが、メカニズムは不明である。今後はマウス疾患モデルを用いてそのメカニズムを明らかにしていく。(今本)4) 国際共同研究により確立した評価方法を用いて、温度変化に起因する細胞膜の物性および膜脂質の分子動態の評価を進める。(梅田)5) FNDを細胞内の特定のオルガネラターゲティングする方法の開発を目的にFND表面のポリマー修飾を行なう。(原田)6) ケンブリッジ大学医学研究所に研究者を派遣し、小胞体の観察法やその微小物理環境解析法を習得する。また、この技術を用いて小胞体の局在や状態解析と温度イメージングを同時に行い細胞内温度シグナリングの分子機構を解明する。(岡部)7) さらに共同研究を進め、得られた知見に関して、論文などでの発表準備を進める。(中村)8)飢餓時に認められる個体レベルのエネルギー消費の低下に、肝臓由来の液性因子を介する新規の臓器連関が関与していることが解明できたため、論文作成を進めている。(山田)9) 引き続き英MRC研究所、仏INSERM、米シンシナティ病院の共同研究者らと密な情報交換を行って共同研究を推進する。(土居)10) アストロサイト特異的TRPV4KOマウスを作製済であり、カルシウム活動・細胞代謝・細胞内温度の変化を調べる。(柴崎)

  14. Elucidation of neural circuit mechanisms underlying autonomic and behavioral controls of body temperature and metabolism

    Grant number:15H05932  2015.6 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

    Nakamura Kazuhiro

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    Authorship:Principal investigator 

    Grant amount:\167310000 ( Direct Cost: \128700000 、 Indirect Cost:\38610000 )

    Thermal homeostasis, which is the nature to maintain internal body temperature within a narrow range, is particularly essential for homeothermic animals including humans, because all biological reactions and functions are affected by temperature. This study was performed to elucidate the neural circuit mechanisms underlying autonomic and behavioral controls of body temperature and metabolism. Specifically, we succeeded in the discoveries of the central ascending neural pathways that transmit thermosensory information for behavioral thermoregulation, the central circuit mechanism that drives hunger responses, and the central psychosomatic mechanism that connects the brain circuits processing psychological stress and emotion with those controlling vital functions. These circuit mechanisms we discovered not only underlie thermal homeostasis, but also function for the defence of life from a variety of environmental stressors.

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Teaching Experience (On-campus) 15

  1. 生体の機能II

    2021

  2. Neuroscience Course

    2021

  3. 基盤医科学実習(ベーシックトレーニング)

    2021

  4. 基礎医学セミナー

    2021

  5. Physiology of Human Body

    2021

  6. 生体の機能I(実習)

    2021

  7. 基礎セミナーB

    2021

  8. 生体の機能I(講義)

    2021

  9. 基盤医科学実習(ベーシックトレーニング)

    2020

  10. 基礎医学セミナー

    2020

  11. Physiology of Human Body

    2020

  12. Neuroscience course

    2020

  13. 生体の機能II

    2020

  14. 生体の機能I(実習)

    2020

  15. 生体の機能I(講義)

    2020

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