Updated on 2024/02/09

写真a

 
SATO Yoshitaka
 
Organization
Graduate School of Medicine Program in Integrated Medicine Microbiology and Immunology Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor
External link

Degree 2

  1. 博士(医学) ( 2013.6   名古屋大学 ) 

  2. 修士(工学) ( 2006.3   名古屋大学 ) 

Research Areas 1

  1. Life Science / Virology

Current Research Project and SDGs 1

  1. ヒト腫瘍ウイルスEBVの理解と制御など

Research History 9

  1. Nagoya University   Graduate School of Medicine Program in Integrated Medicine Microbiology and Immunology   Associate professor

    2022.5

  2. Harvard Medical School/Brigham Women's Hospital

    2022.8 - 2022.10

  3. 名古屋大学大学院   医学系研究科 微生物免疫学講座 ウイルス学   講師

    2020.4 - 2022.4

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    Country:Japan

  4. JST   さきがけ研究者(兼任)

    2019.10 - 2022.3

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    Country:Japan

  5. 名古屋大学大学院   医学系研究科 微生物免疫学講座 ウイルス学   助教

    2015.7 - 2020.3

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    Country:Japan

  6. Nagoya University   Nagoya University Hospital Center of National University Hospital for Infection Control

    2015.4

  7. 名古屋大学大学院   医学系研究科 附属医学教育研究支援センター   特任助教

    2015.4 - 2015.6

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    Country:Japan

  8. 名古屋大学医学部附属病院   初期研修医

    2013.4 - 2015.3

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    Country:Japan

  9. 日本学術振興会 特別研究員DC1

    2007.4 - 2009.3

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    Country:Japan

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Education 4

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2013.6

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    Country: Japan

  2. Kobe University   Faculty of Medicine

    - 2013.3

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    Country: Japan

  3. Nagoya University   Graduate School, Division of Engineering

    - 2006.3

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    Country: Japan

  4. Nagoya University   Faculty of Engineering

    - 2004.3

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    Country: Japan

Professional Memberships 5

  1. 日本ウイルス学会

  2. 日本癌学会

  3. 日本感染症学会

  4. 日本渡航医学会

  5. 日本臨床ウイルス学会

Committee Memberships 3

  1. 文部科学省   学術審議官  

    2021.8   

  2. 日本渡航医学会   評議員  

    2021.7   

  3. 日本ウイルス学会   評議員  

    2018.9   

Awards 5

  1. 日本ウイルス学会 杉浦賞

    2019.10   日本ウイルス学会  

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    Country:Japan

  2. 日本臨床ウイルス学会 若手奨励賞

    2019.5   日本臨床ウイルス学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  3. Poster Prize at the 17th International Symposium on EBV and associated diseases

    2016.8  

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    Award type:Award from international society, conference, symposium, etc.  Country:Switzerland

  4. 第12回EBウイルス研究会学術奨励賞

    2015.7   EBウイルス研究会  

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    Country:Japan

  5. ASM travel grants

    2008.3  

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

 

Papers 72

  1. Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation. Reviewed

    Sagou K, Sato Y, Okuno Y, Watanabe T, Inagaki T, Motooka Y, Toyokuni S, Murata T, Kiyoi H, Kimura H

    PLoS pathogens   Vol. 20 ( 2 ) page: e1011954   2024.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.ppat.1011954

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  2. Generalized Verrucosis on a Background of 3C Syndrome Treated With Subcutaneous IgG Supplementation Reviewed

    Fukaura, R; Terashima-Murase, C; Tanahashi, K; Sato, Y; Kawase, M; Kato, K; Akiyama, M

    JAMA DERMATOLOGY   Vol. 159 ( 12 ) page: 1397 - 1399   2023.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1001/jamadermatol.2023.3801

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  3. Giant condyloma of Buschke-Lowenstein in a Netherton syndrome patient, successfully treated with cryotherapy and intravenous immunoglobulin Reviewed

    Sawa, M; Murase, C; Yamada, N; Fukaura, R; Tetsuka, N; Sato, Y; Takeichi, T; Akiyama, M

    JOURNAL OF DERMATOLOGY   Vol. 50 ( 9 ) page: E289 - E291   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1346-8138.16798

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  4. Growth Transformation of B Cells by Epstein-Barr Virus Requires <i>IMPDH2</i> Induction and Nucleolar Hypertrophy Reviewed

    Sugimoto, A; Watanabe, T; Matsuoka, K; Okuno, Y; Yanagi, Y; Narita, Y; Mabuchi, S; Nobusue, H; Sugihara, E; Hirayama, M; Ide, T; Onouchi, T; Sato, Y; Kanda, T; Saya, H; Iwatani, Y; Kimura, H; Murata, T

    MICROBIOLOGY SPECTRUM   Vol. 11 ( 4 ) page: e0044023   2023.8

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    DOI: 10.1128/spectrum.00440-23

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  5. Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation Reviewed

    Taga, S; Suga, H; Nakano, T; Kuwahara, A; Inoshita, N; Kodani, Y; Nagasaki, H; Sato, Y; Tsumura, Y; Sakakibara, M; Soen, M; Miwata, T; Ozaki, H; Kano, M; Watari, K; Ikeda, A; Yamanaka, M; Takahashi, Y; Kitamoto, S; Kawaguchi, Y; Miyata, T; Kobayashi, T; Sugiyama, M; Onoue, T; Yasuda, Y; Hagiwara, D; Iwama, S; Tomigahara, Y; Kimura, T; Arima, H

    STEM CELL REPORTS   Vol. 18 ( 8 ) page: 1657 - 1671   2023.8

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    DOI: 10.1016/j.stemcr.2023.05.002

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  6. Epstein-Barr Virus BBLF1 Mediates Secretory Vesicle Transport to Facilitate Mature Virion Release Reviewed

    Uddin, MK; Watanabe, T; Arata, M; Sato, Y; Kimura, H; Murata, T

    JOURNAL OF VIROLOGY   Vol. 97 ( 6 ) page: e0043723   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/jvi.00437-23

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  7. The Epstein-Barr Virus Enhancer Interaction Landscapes in Virus-Associated Cancer Cell Lines Reviewed International coauthorship

    Ding, WY; Wang, C; Narita, Y; Wang, HB; Leong, MML; Huang, A; Liao, YF; Liu, XF; Okuno, Y; Kimura, H; Gewurz, B; Teng, MX; Jin, SL; Sato, Y; Zhao, B

    JOURNAL OF VIROLOGY   Vol. 96 ( 18 ) page: e0073922   2022.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/jvi.00739-22

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  8. Comprehensive Analyses of Intraviral Epstein-Barr Virus Protein-Protein Interactions Hint Central Role of BLRF2 in the Tegument Network Reviewed

    Hara, Y; Watanabe, T; Yoshida, M; Al Masud, HMA; Kato, H; Kondo, T; Suzuki, R; Kurose, S; Uddin, MK; Arata, M; Miyagi, S; Yanagi, Y; Sato, Y; Kimura, H; Murata, T

    JOURNAL OF VIROLOGY   Vol. 96 ( 14 ) page: e0051822   2022.7

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    DOI: 10.1128/jvi.00518-22

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  9. Genome-wide CRISPR screen for HSV-1 host factors reveals PAPSS1 contributes to heparan sulfate synthesis Reviewed

    Suzuki, T; Sato, Y; Okuno, Y; Goshima, F; Mikami, T; Umeda, M; Murata, T; Watanabe, T; Watashi, K; Wakita, T; Kitagawa, H; Kimura, H

    COMMUNICATIONS BIOLOGY   Vol. 5 ( 1 ) page: 694   2022.7

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42003-022-03581-9

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  10. Direct reprogramming of adult adipose-derived regenerative cells toward cardiomyocytes using six transcriptional factors Reviewed

    Narita, S; Unno, K; Kato, K; Okuno, Y; Sato, Y; Tsumura, Y; Fujikawa, Y; Shimizu, Y; Hayashida, R; Kondo, K; Shibata, R; Murohara, T

    ISCIENCE   Vol. 25 ( 7 ) page: 104651   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.isci.2022.104651

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  11. Elderly-onset systemic Epstein-Barr virus-positive T-cell lymphoma of childhood Reviewed

    Nishikubo, M; Hiramoto, N; Yamashita, D; Imoto, H; Sato, Y; Okuno, Y; Haga, H; Nannya, Y; Ogawa, S; Kimura, H; Ishikawa, T

    PATHOLOGY INTERNATIONAL   Vol. 72 ( 7 ) page: 376 - 378   2022.7

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    DOI: 10.1111/pin.13231

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  12. Epstein-Barr virus tegument protein BGLF2 in exosomes released from virus-producing cells facilitates de novo infection Reviewed

    Sato, Y; Yaguchi, M; Okuno, Y; Ishimaru, H; Sagou, K; Ozaki, S; Suzuki, T; Inagaki, T; Umeda, M; Watanabe, T; Fujimuro, M; Murata, T; Kimura, H

    CELL COMMUNICATION AND SIGNALING   Vol. 20 ( 1 ) page: 95   2022.6

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12964-022-00902-7

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  13. EBV Exploits RNA m<SUP>6</SUP>A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle

    Yanagi, Y; Watanabe, T; Hara, Y; Sato, Y; Kimura, H; Murata, T

    FRONTIERS IN MICROBIOLOGY   Vol. 13   page: 870816   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fmicb.2022.870816

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  14. PD-L1 upregulation by lytic induction of Epstein-Barr Virus

    Yanagi, Y; Hara, Y; Mabuchi, S; Watanabe, T; Sato, Y; Kimura, H; Murata, T

    VIROLOGY   Vol. 568   page: 31 - 40   2022.3

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    DOI: 10.1016/j.virol.2022.01.006

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  15. In Silico Analysis and Synthesis of Nafamostat Derivatives and Evaluation of Their Anti-SARS-CoV-2 Activity

    Fujimoto, KJ; Hobbs, DCF; Umeda, M; Nagata, A; Yamaguchi, R; Sato, Y; Sato, A; Ohmatsu, K; Ooi, T; Yanai, T; Kimura, H; Murata, T

    VIRUSES-BASEL   Vol. 14 ( 2 )   2022.2

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    DOI: 10.3390/v14020389

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  16. RNAseq analysis identifies involvement of EBNA2 in PD-L1 induction during EBV infection of primary B cells

    Yanagi, Y; Okuno, Y; Narita, Y; Watanabe, T; Sato, Y; Kanda, T; Kimura, H; Murata, T

    CANCER SCIENCE   Vol. 113   page: 1662 - 1662   2022.2

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  17. A STING inhibitor suppresses EBV-induced B cell transformation and lymphomagenesis

    Miyagi, S; Watanabe, T; Hara, Y; Arata, M; Uddin, MK; Mantoku, K; Sago, K; Yanagi, Y; Suzuki, T; Al Masud, HMA; Kawada, J; Nakamura, S; Miyake, Y; Sato, Y; Murata, T; Kimura, H

    CANCER SCIENCE   Vol. 112 ( 12 ) page: 5088 - 5099   2021.12

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    DOI: 10.1111/cas.15152

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  18. Molecular Basis of Epstein-Barr Virus Latency Establishment and Lytic Reactivation

    Murata, T; Sugimoto, A; Inagaki, T; Yanagi, Y; Watanabe, T; Sato, Y; Kimura, H

    VIRUSES-BASEL   Vol. 13 ( 12 )   2021.12

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    DOI: 10.3390/v13122344

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  19. Deletion of Viral microRNAs in the Oncogenesis of Epstein-Barr Virus-Associated Lymphoma

    Kimura, H; Okuno, Y; Sato, Y; Watanabe, T; Murata, T

    FRONTIERS IN MICROBIOLOGY   Vol. 12   page: 667968   2021.7

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    DOI: 10.3389/fmicb.2021.667968

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  20. RNAseq analysis identifies involvement of EBNA2 in PD-L1 induction during Epstein-Barr virus infection of primary B cells

    Yanagi, Y; Okuno, Y; Narita, Y; Al Masud, HMA; Watanabe, T; Sato, Y; Kanda, T; Kimura, H; Murata, T

    VIROLOGY   Vol. 557   page: 44 - 54   2021.5

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    DOI: 10.1016/j.virol.2021.02.004

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  21. Oncolytic activity of naturally attenuated herpes-simplex virus HF10 against an immunocompetent model of oral carcinoma

    Takano, G; Esaki, S; Goshima, F; Enomoto, A; Hatano, Y; Ozaki, H; Watanabe, T; Sato, Y; Kawakita, D; Murakami, S; Murata, T; Nishiyama, Y; Iwasaki, S; Kimura, H

    MOLECULAR THERAPY-ONCOLYTICS   Vol. 20   page: 220 - 227   2021.3

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    DOI: 10.1016/j.omto.2020.12.007

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  22. Anti-tumor effect of IL2-expressing HSV amplicon vector and oncolytic virus HF10

    Esaki, S; Goshima, F; Takano, G; Watanabe, T; Sato, Y; Murata, T; Kimura, H

    CANCER SCIENCE   Vol. 112   page: 394 - 394   2021.2

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  23. Role of Epstein-Barr Virus C Promoter Deletion in Diffuse Large B Cell Lymphoma

    Mabuchi, S; Hijioka, F; Watanabe, T; Yanagi, Y; Okuno, Y; Al Masud, HMA; Sato, Y; Murata, T; Kimura, H

    CANCERS   Vol. 13 ( 3 )   2021.2

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    DOI: 10.3390/cancers13030561

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  24. Direct Evidence of Abortive Lytic Infection-Mediated Establishment of Epstein-Barr Virus Latency During B-Cell Infection Reviewed

    Inagaki, T; Sato, Y; Ito, J; Takaki, M; Okuno, Y; Yaguchi, M; Al Masud, HMA; Watanabe, T; Sato, K; Iwami, S; Murata, T; Kimura, H

    FRONTIERS IN MICROBIOLOGY   Vol. 11   page: 575255   2021.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fmicb.2020.575255

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  25. Bursitis, Bacteremia, and Disseminated Infection of <i>Mycobacteroides</i> <i>(Mycobacterium) abscessus</i> subsp. <i>massiliense</i>

    Oka, K; Morioka, H; Eguchi, M; Sato, Y; Tetsuka, N; Iguchi, M; Kanematsu, T; Fukano, H; Hoshino, Y; Kiyoi, H; Yagi, T

    INTERNAL MEDICINE   Vol. 60 ( 18 ) page: 3041 - 3045   2021

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.6189-20

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  26. Oncolytic activity of HF10 in head and neck squamous cell carcinomas.

    Esaki S, Goshima F, Ozaki H, Takano G, Hatano Y, Kawakita D, Ijichi K, Watanabe T, Sato Y, Murata T, Iwata H, Shibamoto Y, Murakami S, Nishiyama Y, Kimura H

    Cancer gene therapy   Vol. 27 ( 7-8 ) page: 585 - 598   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41417-019-0129-3

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  27. Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days

    Sato, Y; Iguchi, M; Kato, Y; Morioka, H; Hirabayashi, A; Tetsuka, N; Tomita, Y; Kato, D; Yamada, K; Kimura, H; Yagi, T

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 3 ) page: 407 - 414   2020.8

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    DOI: 10.18999/nagjms.82.3.407

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  28. Oncogenesis of CAEBV revealed: Intragenic deletions in the viral genome and leaky expression of lytic genes

    Murata Takayuki, Okuno Yusuke, Sato Yoshitaka, Watanabe Takahiro, Kimura Hiroshi

    REVIEWS IN MEDICAL VIROLOGY   Vol. 30 ( 2 ) page: e2095   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/rmv.2095

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  29. Antitumor activity of cyclin-dependent kinase inhibitor alsterpaullone in Epstein-Barr virus-associated lymphoproliferative disorders

    Watanabe Takahiro, Sato Yoshitaka, Al Masud H. M. Abdullah, Takayama Masahiro, Matsuda Hiroki, Hara Yuya, Yanagi Yusuke, Yoshida Masahiro, Goshima Fumi, Murata Takayuki, Kimura Hiroshi

    CANCER SCIENCE   Vol. 111 ( 1 ) page: 279 - 287   2020.1

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    DOI: 10.1111/cas.14241

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  30. [Dynamic changes of cellular environment during Epstein-Barr virus productive replication]. Invited

    Sato Y

    Uirusu   Vol. 70 ( 1 ) page: 83 - 90   2020

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)  

    DOI: 10.2222/jsv.70.83

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  31. Epstein-Barr Virus BBRF2 Is Required for Maximum Infectivity

    Al Masud H. M. Abdullah, Yanagi Yusuke, Watanabe Takahiro, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

    MICROORGANISMS   Vol. 7 ( 12 )   2019.12

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    DOI: 10.3390/microorganisms7120705

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  32. The BOLF1 gene is necessary for effective Epstein-Barr viral infectivity.

    Masud HMAA, Watanabe T, Sato Y, Goshima F, Kimura H, Murata T

    Virology   Vol. 531   page: 114 - 125   2019.5

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    DOI: 10.1016/j.virol.2019.02.015

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  33. S-like phase CDKs stabilize the Epstein-Barr virus BDLF4 protein to temporally control late gene transcription.

    Sato Y, Watanabe T, Suzuki C, Abe Y, Masud HMAA, Inagaki T, Yoshida M, Suzuki T, Goshima F, Adachi J, Tomonaga T, Murata T, Kimura H

    Journal of virology   Vol. 93 ( 8 )   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JVI.01707-18

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  34. Initial Characterization of the Epstein-Barr Virus BSRF1 Gene Product

    Yanagi Yusuke, Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi, Murata Takayuki

    VIRUSES-BASEL   Vol. 11 ( 3 )   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/v11030285

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  35. Defective Epstein-Barr virus in chronic active infection and haematological malignancy.

    Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H

    Nature microbiology   Vol. 4 ( 3 ) page: 404 - 413   2019.3

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    DOI: 10.1038/s41564-018-0334-0

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  36. Challenges in Managing EBV-Associated T- and NK-Cell Lymphoproliferative Diseases

    Sato Yoshitaka

    FRONTIERS IN PEDIATRICS   Vol. 6   page: 320   2018.11

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    DOI: 10.3389/fped.2018.00320

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  37. Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells

    Ichikawa Takaya, Okuno Yusuke, Sato Yoshitaka, Goshima Fumi, Yoshiyama Hironori, Kanda Teru, Kimura Hiroshi, Murata Takayuki

    MSPHERE   Vol. 3 ( 6 )   2018.11

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    DOI: 10.1128/mSphere.00478-18

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  38. Antitumor effects of duvelisib on Epstein-Barr virus-associated lymphoma cells.

    Kawada JI, Ando S, Torii Y, Watanabe T, Sato Y, Ito Y, Kimura H

    Cancer medicine   Vol. 7 ( 4 ) page: 1275 - 1284   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cam4.1311

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  39. BGLF2 Increases Infectivity of Epstein-Barr Virus by Activating AP-1 upon De Novo Infection

    Konishi Natsuno, Narita Yohei, Hijioka Fumiya, Al Masud H. M. Abdullah, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

    MSPHERE   Vol. 3 ( 2 )   2018.3

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    DOI: 10.1128/mSphere.00138-18

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  40. Epstein-Barr Virus BKRF4 Gene Product Is Required for Efficient Progeny Production.

    Masud HMAA, Watanabe T, Yoshida M, Sato Y, Goshima F, Kimura H, Murata T

    Journal of virology   Vol. 91 ( 23 )   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JVI.00975-17

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  41. Characterization of a Suppressive <i>Cis</i>-acting Element in the Epstein-Barr Virus LMP1 Promoter.

    Yoshida M, Murata T, Ashio K, Narita Y, Watanabe T, Masud HMAA, Sato Y, Goshima F, Kimura H

    Frontiers in microbiology   Vol. 8   page: 2302   2017.11

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    DOI: 10.3389/fmicb.2017.02302

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  42. The Epstein-Barr Virus BRRF1 Gene Is Dispensable for Viral Replication in HEK293 cells and Transformation.

    Yoshida M, Watanabe T, Narita Y, Sato Y, Goshima F, Kimura H, Murata T

    Scientific reports   Vol. 7 ( 1 ) page: 6044   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-06413-7

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  43. Elimination of LMP1-expressing cells from a monolayer of gastric cancer AGS cells.

    Sato Y, Ochiai S, Murata T, Kanda T, Goshima F, Kimura H

    Oncotarget   Vol. 8 ( 24 ) page: 39345 - 39355   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.16996

    Web of Science

    PubMed

  44. The C-Terminus of Epstein-Barr Virus BRRF2 Is Required for its Proper Localization and Efficient Virus Production.

    Watanabe T, Sakaida K, Yoshida M, Masud HM, Sato Y, Goshima F, Kimura H, Murata T

    Frontiers in microbiology   Vol. 8   page: 125   2017.1

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    DOI: 10.3389/fmicb.2017.00125

    Web of Science

    PubMed

  45. The efficacy of combination therapy with oncolytic herpes simplex virus HF10 and dacarbazine in a mouse melanoma model. Reviewed

    Tanaka R, Goshima F, Esaki S, Sato Y, Murata T, Nishiyama Y, Watanabe D, Kimura H

    American journal of cancer research   Vol. 7 ( 8 ) page: 1693 - 1703   2017

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  46. The efficacy of combination therapy with oncolytic herpes simplex virus HF10 and dacarbazine in a mouse melanoma model Reviewed

    Tanaka Rui, Goshima Fumi, Esaki Shinichi, Sato Yoshitaka, Murata Takayuki, Nishiyama Yukihiro, Watanabe Daisuke, Kimura Hiroshi

    AMERICAN JOURNAL OF CANCER RESEARCH   Vol. 7 ( 8 ) page: 1693-1703   2017

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    Web of Science

  47. Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. Reviewed

    Ando S, Kawada JI, Watanabe T, Suzuki M, Sato Y, Torii Y, Asai M, Goshima F, Murata T, Shimizu N, Ito Y, Kimura H

    Oncotarget   Vol. 7 ( 47 ) page: 76793-76805   2016.11

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    DOI: 10.18632/oncotarget.12529

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  48. Induction of Epstein-Barr Virus Oncoprotein LMP1 by Transcription Factors AP-2 and Early B Cell Factor. Reviewed

    Murata T, Noda C, Narita Y, Watanabe T, Yoshida M, Ashio K, Sato Y, Goshima F, Kanda T, Yoshiyama H, Tsurumi T, Kimura H

    Journal of virology   Vol. 90 ( 8 ) page: 3873-89   2016.4

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    DOI: 10.1128/JVI.03227-15

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  49. Induction of Epstein-Barr Virus Oncoprotein Latent Membrane Protein 1 (LMP1) by Transcription Factors Activating Protein 2 (AP-2) and Early B Cell Factor (EBF) Reviewed

    Takayuki Murata, Chieko Noda, Yohei Narita, Takahiro Watanabe, Masahiro Yoshida, Keiji Ashio, Yoshitaka Sato, Fumi Goshima, Teru Kanda, Hironori Yoshiyama, Tatsuya Tsurumi, and Hiroshi Kimura

    Journal of Virology   Vol. 90   page: 3873-3889   2016

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  50. The Epstein-Barr Virus BDLF4 Gene Is Required for Efficient Expression of Viral Late Lytic Genes. Reviewed

    Watanabe T, Narita Y, Yoshida M, Sato Y, Goshima F, Kimura H, Murata T

    Journal of virology   Vol. 89 ( 19 ) page: 10120-4   2015.10

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    DOI: 10.1128/JVI.01604-15

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  51. Anti-CCR4 monoclonal antibody mogamulizumab for the treatment of EBV-associated T- and NK-cell lymphoproliferative diseases. Reviewed

    Kanazawa T, Hiramatsu Y, Iwata S, Siddiquey M, Sato Y, Suzuki M, Ito Y, Goshima F, Murata T, Kimura H

    Clinical cancer research : an official journal of the American Association for Cancer Research   Vol. 20 ( 19 ) page: 5075-84   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/1078-0432.CCR-14-0580

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  52. Role of latent membrane protein 1 in chronic active Epstein-Barr virus infection-derived T/NK-cell proliferation. Reviewed

    Ito T, Kawazu H, Murata T, Iwata S, Arakawa S, Sato Y, Kuzushima K, Goshima F, Kimura H

    Cancer medicine   Vol. 3 ( 4 ) page: 787-95   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cam4.256

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  53. Modes of infection and oncogenesis by the Epstein-Barr virus. Reviewed

    Murata T, Sato Y, Kimura H

    Reviews in medical virology   Vol. 24 ( 4 ) page: 242-53   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/rmv.1786

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  54. Genome guardian p53 and viral infections. Reviewed

    Sato Y, Tsurumi T

    Reviews in medical virology   Vol. 23 ( 4 ) page: 213-20   2013.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/rmv.1738

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  55. Different distributions of Epstein-Barr virus early and late gene transcripts within viral replication compartments. Reviewed

    Sugimoto A, Sato Y, Kanda T, Murata T, Narita Y, Kawashima D, Kimura H, Tsurumi T

    Journal of virology   Vol. 87 ( 12 ) page: 6693-9   2013.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JVI.00219-13

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  56. Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. Reviewed

    Ohsawa S, Sato Y, Enomoto M, Nakamura M, Betsumiya A, Igaki T

    Nature   Vol. 490 ( 7421 ) page: 547-51   2012.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nature11452

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  57. Noise cancellation: viral fine tuning of the cellular environment for its own genome replication. Reviewed

    Sato Y, Tsurumi T

    PLoS pathogens   Vol. 6 ( 12 ) page: e1001158   2010.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.ppat.1001158

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  58. Transient increases in p53-responsible gene expression at early stages of Epstein-Barr virus productive replication. Reviewed

    Sato Y, Shirata N, Murata T, Nakasu S, Kudoh A, Iwahori S, Nakayama S, Chiba S, Isomura H, Kanda T, Tsurumi T

    Cell cycle (Georgetown, Tex.)   Vol. 9 ( 4 ) page: 807-14   2010.2

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  59. Epstein-Barr virus polymerase processivity factor enhances BALF2 promoter transcription as a coactivator for the BZLF1 immediate-early protein. Invited Reviewed

    Nakayama S, Murata T, Murayama K, Yasui Y, Sato Y, Kudoh A, Iwahori S, Isomura H, Kanda T, Tsurumi T

    The Journal of biological chemistry   Vol. 284 ( 32 ) page: 21557-68   2009.8

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    DOI: 10.1074/jbc.M109.015685

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  60. Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication. Reviewed

    Iwahori S, Murata T, Kudoh A, Sato Y, Nakayama S, Isomura H, Kanda T, Tsurumi T

    The Journal of biological chemistry   Vol. 284 ( 28 ) page: 18923-31   2009.7

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    DOI: 10.1074/jbc.M109.015123

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  61. Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex. Reviewed

    Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T

    PLoS pathogens   Vol. 5 ( 7 ) page: e1000530   2009.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.ppat.1000530

    PubMed

  62. Homologous recombinational repair factors are recruited and loaded onto the viral DNA genome in Epstein-Barr virus replication compartments. Reviewed

    Kudoh A, Iwahori S, Sato Y, Nakayama S, Isomura H, Murata T, Tsurumi T

    Journal of virology   Vol. 83 ( 13 ) page: 6641-51   2009.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JVI.00049-09

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  63. Efficient production of infectious viruses requires enzymatic activity of Epstein-Barr virus protein kinase. Reviewed

    Murata T, Isomura H, Yamashita Y, Toyama S, Sato Y, Nakayama S, Kudoh A, Iwahori S, Kanda T, Tsurumi T

    Virology   Vol. 389 ( 1-2 ) page: 75-81   2009.6

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    DOI: 10.1016/j.virol.2009.04.007

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  64. Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription. Reviewed

    Sato Y, Shirata N, Kudoh A, Iwahori S, Nakayama S, Murata T, Isomura H, Nishiyama Y, Tsurumi T

    Virology   Vol. 388 ( 1 ) page: 204-11   2009.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.virol.2009.03.017

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  65. TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein. Reviewed

    Murata T, Sato Y, Nakayama S, Kudoh A, Iwahori S, Isomura H, Tajima M, Hishiki T, Ohshima T, Hijikata M, Shimotohno K, Tsurumi T

    The Journal of biological chemistry   Vol. 284 ( 12 ) page: 8033-41   2009.3

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    DOI: 10.1074/jbc.M808466200

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  66. Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites. Reviewed

    Iwahori S, Yasui Y, Kudoh A, Sato Y, Nakayama S, Murata T, Isomura H, Tsurumi T

    Cellular signalling   Vol. 20 ( 10 ) page: 1795-803   2008.10

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    DOI: 10.1016/j.cellsig.2008.06.007

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  67. Noncanonical TATA sequence in the UL44 late promoter of human cytomegalovirus is required for the accumulation of late viral transcripts. Reviewed

    Isomura H, Stinski MF, Kudoh A, Murata T, Nakayama S, Sato Y, Iwahori S, Tsurumi T

    Journal of virology   Vol. 82 ( 4 ) page: 1638-46   2008.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JVI.01917-07

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  68. A cis element between the TATA Box and the transcription start site of the major immediate-early promoter of human cytomegalovirus determines efficiency of viral replication. Reviewed

    Isomura H, Stinski MF, Kudoh A, Nakayama S, Murata T, Sato Y, Iwahori S, Tsurumi T

    Journal of virology   Vol. 82 ( 2 ) page: 849-58   2008.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JVI.01593-07

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  69. Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein. Reviewed

    Iwahori S, Shirata N, Kawaguchi Y, Weller SK, Sato Y, Kudoh A, Nakayama S, Isomura H, Tsurumi T

    Journal of virology   Vol. 81 ( 18 ) page: 9653-64   2007.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JVI.00568-07

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  70. The late promoter of the human cytomegalovirus viral DNA polymerase processivity factor has an impact on delayed early and late viral gene products but not on viral DNA synthesis. Reviewed

    Isomura H, Stinski MF, Kudoh A, Nakayama S, Iwahori S, Sato Y, Tsurumi T

    Journal of virology   Vol. 81 ( 12 ) page: 6197-206   2007.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JVI.00089-07

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  71. Sumoylation of CCAAT/enhancer-binding protein alpha and its functional roles in hepatocyte differentiation. Reviewed

    Sato Y, Miyake K, Kaneoka H, Iijima S

    The Journal of biological chemistry   Vol. 281 ( 31 ) page: 21629-39   2006.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M600852200

    PubMed

  72. Identification of cis-acting regions that contribute to neuron-specific expression of the GAP-43 gene. Reviewed

    Takahashi M, Sato Y, Nakagami Y, Miyake K, Iijima S

    Bioscience, biotechnology, and biochemistry   Vol. 70 ( 6 ) page: 1492-5   2006.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1271/bbb.50576

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Research Project for Joint Research, Competitive Funding, etc. 8

  1. Deciphering links between emerging environmental pollutants exposure and susceptibility to viral infection International coauthorship

    2022.9 - 2023.3

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    Authorship:Principal investigator  Grant type:Competitive

  2. 内因性微粒子が駆動するウイル ス関連疾患の理解

    2019.10 - 2023.3

    さきがけ「生体における微粒子の機能と制御」領域 

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    Grant type:Competitive

  3. EBV関連NK細胞性腫瘍における スーパーエンハンサーの解析

    2019.9 - 2021.3

    日米医学協力計画 若手・女性育成のための公募 

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    Grant type:Competitive

  4. Epstein-Barrウイルス潜伏感染成立の分子基盤

    2018.7 - 2019.3

    研究助成 

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    Grant type:Competitive

  5. 数理モデルと実験データの融合によるEpstein-Barrウイルス感染のモニタリング

    2018.5 - 2019.9

    研究助成 

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    Grant type:Competitive

  6. EBウイルスゲノム複製装置形成・成熟の分子基盤の解明

    2017.8

    医学系研究奨励 

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    Grant type:Competitive

  7. 食品中に含まれる化学物質が発がんウイルスEBVの増殖に与える影響の解析

    2016.10 - 2017.3

    医学研究・健康増進活動等助成 

    佐藤好隆

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    Grant type:Competitive

  8. CMV/EBVのウイルス後期遺伝子の転写を抑制する小分子の探索

    2015.8 - 2017.3

    GSKジャパン研究助成 

    佐藤好隆

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. Epstein-Barrウイルス蛋白質によるp53の不活化機構の解析

    2007.4 - 2009.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  2. EBウイルスによる細胞外微粒子産生のハイジャック機構の解明

    Grant number:23K06559  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    佐藤 好隆

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    ウイルス感染細胞から放出される粒子は、ウイルス粒子だけではない。エクソソームに代表される細胞外微粒子(EV)はほぼ全ての細胞から放出されるため、当然、ウイルス感染細胞からも放出される。Epstein-Barrウイルス(EBV)は、新規感染の際にEBVは感染細胞から放出されるEVにウイルスタンパク質を内包し、補助的に使用している。しかし、どのようにEBVが宿主のEV産生装置をウイルスがハイジャックして、自身の感染拡大に利用しているかは不明である。そこで、本研究ではEBVがどのようにウイルスタンパク質をEVに内包するのか?およびEV生産をどのように制御するのか?などを明らかにすることを目指す。

  3. Generation of novel human ACTH cells and their application to the treatment of pituitary intractable diseases

    Grant number:22K08657  2022.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  4. Comprehensive single cell analyses to identify novel oncogenes and oncogenic pathways derived from Epstein-Barr virus

    Grant number:22H02878  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s) 

  5. Super-enhancer analysis of EBV-associated T/NK lymphoma

    Grant number:21K15448  2021.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Sato Yoshitaka

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Epstein-Barr virus (EBV) persists in human cells as episomes. EBV episomes are chromatinized and their 3D conformation varies greatly in cells expressing different latency genes. we compared the EBV episome intragenomic interactions in different cancer cell lines expressing three different types of EBV latency genes using a new method, HiChIP. H3K27ac HiChIPs were done in 4 T/NK lymphoma cell lines and 2 primary effusion lymphoma cell lines, together with published data from cell line expressing type III latency genes. We found that in type II latency infected cells, the episome looping patterns were similar to cells expressing type III latency genes. Similar to previous reports using a different method to compare the EBV 3D genome looping using captured Hi-C, more restricted type I latency infected cells had much less loopings. These data suggested that looping is a way for EBV to regulate its oncogene expression in various EBV associated cancer cells.

  6. 周囲の環境に応じた感染細胞の運命決定機構の解明

    Grant number:19H04829  2019.4 - 2021.3

    科学研究費助成事業  新学術領域研究(研究領域提案型)

    佐藤 好隆

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    Authorship:Principal investigator 

    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

    本研究は、感染細胞の外(周囲の環境)に主眼をおき、感染細胞自身ではなく、その周囲の環境も潜伏感染の成立・維持に寄与するという新たな原理とその分子基盤の解明を目指す。全人口の90%以上が感染しているEpstein-Barrウイルスを主な研究対象として、周囲の環境が感染細胞の運命決定(潜伏感染を継続するか溶解感染へ移行するかなど)に、どのような影響を及ぼすかを解析する。EBV は、感染者の一部に腫瘍を引き起こすが、ほとんどは不顕性感染状態である。病原性と非病原性が同居するウイルスであり、本研究は従来のウイルス学とネオウイルス学の2つのウイルス学の発展と理解に貢献する。
    ウイルスは効率よく子孫ウイルスを標的細胞に感染させるため、宿主に寄り添って(寄り添うフリをして)、感染に有利な環境になるのを宿主内でじっと待つ(潜伏 感染)。そして、宿主を裏切り、ウイルス粒子の産生(溶解感染)を起こす。 全人口の90%以上が感染しているEpstein-Barrウイルス(EBV)を主な研究対象として、周囲の環境が感染細胞の運命決定(潜伏感染を継続するか溶解感染へ移行するかなど)に、どのような影響を及ぼすかを解析した。
    1) EBV初感染時の一時的な不完全溶解感染
    B細胞にEBVを感染させ、RNAseq解析を実施したところ、感染直後にウイルス産生に関わる遺伝子群が一時的に発現していることが確認出来た。しかし、RNAseqは集団での遺伝子発現を捉えるスナップショットに過ぎず、各細胞でどのような変化が起きているのかという情報は得られない。そこで、組換えウイルスを用いたFate mappingにより、直接的に感染細胞の運命を追えるシステムを開発し、EBVが感染すると、直後に一旦溶解感染遺伝子を発現してから潜伏状態となるということを世界に先駆けて証明した。
    2) EBVのcell-free感染を促進する代謝産物
    EBV感染のダイナミクスを経時的に追い、 EBV感染の広がりを数理モデル化する過程の中で、振とう(shaking)を行うと培養上清中に増加する因子によりEBVのcell-free感染が促進することが明らかにした。この因子を同定するため、メタボロミクス解析を実施し、2つの代謝産物を責任因子として同定した。EBVのcell-free感染が促進されるメカニズムを今後詳細に解析することで、周囲の環境がEBV感染に与える影響を明らかにしていきたい。ウイルス感染の理解には、ウイルスと宿主の単純な関係ではなく、より複雑な関係を理解する必要があることが本研究より示唆された。
    令和2年度が最終年度であるため、記入しない。
    令和2年度が最終年度であるため、記入しない。

  7. A genome-wide knockout screen identified host factors modulating herpes simplex virus infection

    Grant number:16H06231  2016.4 - 2020.3

    SATO Yoshitaka

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    Authorship:Principal investigator 

    Grant amount:\25220000 ( Direct Cost: \19400000 、 Indirect Cost:\5820000 )

    Herpes simplex virus (HSV) is a common pathogen that causes skin infection as well as fatal encephalitis. HSV is categorized into 2 types: HSV type 1 (HSV-1) and HSV type 2 (HSV-2). Targeting host factors involved in HSV-infection and -propagation is an attractive approach to regulate those viruses. To identify a set of HSV host factors, we carried out a genome wide CRISPR screen. In this study, we established high quality KO library that showed the presentation of over 98% individual sgRNA. We isolated 53 genes for HSV-1, and 21 genes for HSV-2 as responsible host genes for viral infection and propagation. Among these isolated genes, NECTIN-1 and a series of genes involved in heparan sulfate biosynthesis, which are known for HSV viral receptors, were included. The other candidate genes are currently being investigated. Our study may provide new insights into the molecular mechanism of HSV viral entry and of the tropism that differs between HSV-1 and HSV-2.

  8. Research for the mechanism of latency and immortalization of Epstein-Barr virus using haploid cells

    Grant number:16K15525  2016.4 - 2018.3

    Kimura Hiroshi

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    Authorship:Coinvestigator(s) 

    Epstein-Barr virus (EBV) is associated with a variety of intractable infections and malignancies. HAP-1 cells, which have only one genome set, is suitable for genome screening. In this study, we tried screening of host genes to be associated with latency or immortalization of EBV using HAP-1 cells and next generation sequencing. We successfully generated HAP-1/EBV cells, but could not identify any host genes because of the lack in the maintenance of EBV.

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Industrial property rights 2

  1. 1,2,3-トリアゾール化合物および抗ウイルス剤

    喜多村徳昭, 佐藤好隆

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    Applicant:東海国立大学機構

    Application no:2023-078168  Date applied:2023.5

  2. 抗ウイルス薬

    佐藤好隆, 渡辺崇広, 木村宏

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    Application no:2017-250093  Date applied:2017.12

    Country of applicant:Domestic  

 

Social Contribution 1

  1. ヒトと共存できるウイルスと共存できないウイルス

    Role(s):Lecturer

    名古屋大学 学術研究・産学連携推進本部/愛知サイエンスフェスティバル/サカエ大学  第77回愛知サイエンストーク  2020.10