Updated on 2022/07/05

写真a

 
ABE Hiroshi
 
Organization
Institute for Glyco-core Research Professor
Graduate School of Science Professor
Graduate School
Graduate School of Science
Title
Professor

Degree 1

  1. 博士(薬学) ( 2001.3   北海道大学 ) 

Research Areas 1

  1. Life Science / Bioorganic chemistry

Research History 6

  1. 名古屋大学大学院理学研究科物質理学専攻(化学系)生物化学研究室・教授

    2015.3

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    Country:Japan

  2. Nagoya University   大学院理学研究科 物質理学専攻化学系   Professor

    2015.3

  3. 北海道大学大学院薬学研究院・准教授

    2013.8 - 2015.3

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    Country:Japan

  4. 科学技術振興機構 研究領域:「脳神経回路の形成・動作と制御」・さきがけ研究員

    2011.10 - 2015.3

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    Country:Japan

  5. 独立行政法人理化学研究所・専任研究員

    2009.4 - 2013.7

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    Country:Japan

  6. 独立行政法人理化学研究所・研究員

    2005.6 - 2009.3

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    Country:Japan

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Education 2

  1. Hokkaido University   Graduate School, Division of Pharmaceutical Sciences

    1998.4 - 2001.3

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    Country: Japan

  2. Hokkaido University   Faculty of Pharmaceutical Science

    1988.4 - 1991.3

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    Country: Japan

Professional Memberships 2

  1. 日本薬学会

  2. 日本化学会

Committee Memberships 1

  1. 日本核酸医薬学会   幹事  

       

Awards 1

  1. 学術賞

    2021.6   日本核酸医薬学会  

 

Papers 154

  1. Antisense Oligonucleotide Modified with Disulfide Units Induces Efficient Exon Skipping in mdx Myotubes through Enhanced Membrane Permeability and Nucleus Internalization

    Hiraoka Haruka, Shu Zhaoma, Tri Le Bao, Masuda Keiko, Nakamoto Kosuke, Fangjie Lyu, Abe Naoko, Hashiya Fumitaka, Kimura Yasuaki, Shimizu Yoshihiro, Veedu Rakesh N., Abe Hiroshi

    CHEMBIOCHEM   Vol. 22 ( 24 ) page: 3437 - 3442   2021.12

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  2. Quantification of native mRNA dynamics in living neurons using fluorescence correlation spectroscopy and reduction-triggered fluorescent probes

    Fujita Hirotaka, Oikawa Ryota, Hayakawa Mayu, Tomoike Fumiaki, Kimura Yasuaki, Okuno Hiroyuki, Hatashita Yoshiki, Fiallos Oliveros Carolina, Bito Haruhiko, Ohshima Toshio, Tsuneda Satoshi, Abe Hiroshi, Inoue Takafumi

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 295 ( 23 ) page: 7923 - 7940   2020.6

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  3. Disulfide-unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA

    Nakamoto Kosuke, Shu Zhaoma, Abe Hiroshi

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   Vol. 78 ( 5 ) page: 456 - 464   2020.5

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    Language:Japanese  

    Web of Science

  4. Translational control by secondary-structure formation in mRNA in a eukaryotic system

    Kawaguchi Daisuke, Shimizu Saaya, Abe Naoko, Hashiya Fumitaka, Tomoike Fumiaki, Kimura Yasuaki, Abe Hiroshi

    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS   Vol. 39 ( 1-3 ) page: 195 - 203   2020.2

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  5. A robust model for quantitative prediction of the silencing efficacy of wild-type and A-to-I edited miRNAs

    Tian Shen, Terai Goro, Kobayashi Yoshiaki, Kimura Yasuaki, Abe Hiroshi, Asai Kiyoshi, Ui-Tei Kumiko

    RNA BIOLOGY   Vol. 17 ( 2 ) page: 264 - 280   2020.2

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  6. SYNTHESIS AND BIOLOGICAL EVALUATION OF NMDI14 DERIVATIVES AS ANTI-MESOTHELIOMA AGENTS

    Hong Nhung Nguyen, Suzuki Koya, Kimura Yasuaki, Hirokawa Takatsugu, Murakami-Tonami Yuko, Abe Hiroshi

    HETEROCYCLES   Vol. 100 ( 2 ) page: 253 - 266   2020.2

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    Language:Japanese  

    DOI: 10.3987/COM-19-14191

    Web of Science

  7. Intracellular Delivery of Antisense DNA and siRNA with Amino Groups Masked with Disulfide Units

    Shu Zhaoma, Ota Azumi, Takayama Yukiya, Katsurada Yuri, Kusamori Kosuke, Abe Naoko, Nakamoto Kosuke, Tomoike Fumiaki, Tada Seiichi, Ito Yoshihiro, Nishikawa Makiya, Kimura Yasuaki, Abe Hiroshi

    CHEMICAL & PHARMACEUTICAL BULLETIN   Vol. 68 ( 2 ) page: 129 - 132   2020.2

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    Language:Japanese  

    Web of Science

  8. Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors

    Kimura Yasuaki, Shu Zhaoma, Ito Mika, Abe Naoko, Nakamoto Kosuke, Tomoike Fumiaki, Shuto Satoshi, Ito Yoshihiro, Abe Hiroshi

    CHEMICAL COMMUNICATIONS   Vol. 56 ( 3 ) page: 466 - 469   2020.1

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  9. Intracellular Delivery of Antisense DNA and siRNA with Amino Groups Masked with Disulfide Units.

    Shu Z, Ota A, Takayama Y, Katsurada Y, Kusamori K, Abe N, Nakamoto K, Tomoike F, Tada S, Ito Y, Nishikawa M, Kimura Y, Abe H

    Chemical & pharmaceutical bulletin   Vol. 68 ( 2 ) page: 129 - 132   2020

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    Language:English  

    DOI: 10.1248/cpb.c19-00811

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  10. N-6-methyl adenosine in siRNA evades immune response without reducing RNAi activity

    Imaeda Akihiro, Tomoike Fumiaki, Hayakawa Mayu, Nakamoto Kosuke, Kimura Yasuaki, Abe Naoko, Abe Hiroshi

    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS   Vol. 38 ( 12 ) page: 972 - 979   2019.12

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  11. Disulfide-Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA

    Shu Zhaoma, Tanaka Iku, Ota Azumi, Fushihara Daichi, Abe Naoko, Kawaguchi Saki, Nakamoto Kosuke, Tomoike Fumiaki, Tada Seiichi, Ito Yoshihiro, Kimura Yasuaki, Abe Hiroshi

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 58 ( 20 ) page: 6611 - 6615   2019.5

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  12. A Covalent Inhibitor for Glutathione S-Transferase Pi (GSTP(1-1)) in Human Cells

    Shishido Yuko, Tomoike Fumiaki, Kuwata Keiko, Fujikawa Haruka, Sekido Yoshitaka, Murakami-Tonami Yuko, Kameda Tomoshi, Abe Naoko, Kimura Yasuaki, Shuto Satoshi, Abe Hiroshi

    CHEMBIOCHEM   Vol. 20 ( 7 ) page: 900 - 905   2019.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cbic.201800671

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  13. Structural optimization of pseudorotaxane-forming oligonucleotides for efficient and stable complex formation

    Onizuka Kazumitsu, Miyashita Takuya, Chikuni Tomoko, Ozawa Mamiko, Abe Hiroshi, Nagatsugi Fumi

    NUCLEIC ACIDS RESEARCH   Vol. 46 ( 17 ) page: 8710 - 8719   2018.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gky744

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  14. MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation

    Brautigam Lars, Zhang Jie, Dreij Kristian, Spahiu Linda, Holmgren Arne, Abe Hiroshi, Tew Kenneth D., Townsend Danyelle M., Kelner Michael J., Morgenstern Ralf, Johansson Katarina

    REDOX BIOLOGY   Vol. 17   page: 171 - 179   2018.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.redox.2018.04.013

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  15. Complete chemical synthesis of long DNA transcriptable in human cells

    Kazuki Yamaoka, Ryota Oikawa, Naoko Abe, Kosuke Nakamoto, Fumiaki Tomoike, Fumitaka Hashiya, Yasuaki Kimura, Hiroshi Abe

    ChemBioChem   Vol. 22 ( 23 ) page: 3273 - 3276   2021.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/cbic.202100312

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  16. Variety of nucleotide polymerase mutants aiming to synthesize modified RNA

    Sana Ohashi, Fumitaka Hashiya, Hiroshi Abe

    ChemBioChem   Vol. 22 ( 14 ) page: 2398 - 2406   2021.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/cbic.202100004

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  17. Structure, Synthesis and Inhibition Mechanism of Nucleoside Analogues as HIV‐1 Reverse Transcriptase Inhibitors (NRTIs)

    Yuki Yoshida, Masakazu Honma, Yasuaki Kimura, Hiroshi Abe

    ChemMedChem   Vol. 16 ( 5 ) page: 743 - 766   2021.3

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/cmdc.202000695

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cmdc.202000695

  18. Chemical Synthesis of Circular RNAs with Phosphoramidate Linkages for Rolling‐Circle Translation

    Kosuke Nakamoto, Hiroshi Abe

    Current Protocols   Vol. 1 ( 3 ) page: e43   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/cpz1.43

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cpz1.43

  19. Phosphorothioate Modification of mRNA Accelerates Rate of Translation Initiation Providing More Efficient Protein Synthesis Reviewed

    Hiroshi Abe, Daisuke Kawaguchi, Ayumi Kodama, Naoko Abe, Kei Takebuchi, Fumitaka Hashiya, Fumiaki Tomoike, Kousuke Nakamoto, Yasuaki Kimura, Yoshihiro Shimizu

    Angewandte Chemie International Edition   Vol. 59 ( 40 ) page: 17403 - 17407   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/anie.202007111

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  20. Free-Energy Calculation of Ribonucleic Inosines and Its Application to Nearest-Neighbor Parameters

    Shun Sakuraba, Junichi Iwakiri, Michiaki Hamada, Tomoshi Kameda, Genichiro Tsuji, Yasuaki Kimura, Hiroshi Abe, Kiyoshi Asai

    Journal of Chemical Theory and Computation   Vol. 16 ( 9 ) page: 5923 - 5935   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acs.jctc.0c00270

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  21. Developments in siRNA Modification and Ligand Conjugated Delivery To Enhance RNA Interference Ability. International journal

    Ander Maguregui, Hiroshi Abe

    Chembiochem : a European journal of chemical biology   Vol. 21 ( 13 ) page: 1808 - 1815   2020.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    There is great potential for siRNA in the treatment of diseases through the reduction of damaging protein translation by RNA interference. However, the delivery and cell uptake of siRNA pose a serious problem in its therapeutic application. Methods to overcome this issue include chemical modification of the siRNA duplex to improve pharmacokinetics, stability and efficacy, and conjugation to small ligand molecules to enable membrane penetration, targetability and potency. In this review, the most common modifications of siRNA will be discussed, along with ligand conjugates that are believed to be the most promising in advancing the field of targeted siRNA delivery.

    DOI: 10.1002/cbic.202000009

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  22. Chemically synthesized circular RNAs with phosphoramidate linkages enable rolling circle translation Reviewed

    Kosuke Nakamoto, Naoko Abe, Genichiro Tsuji, Yasuaki Kimura, Fumiaki Tomoike, Yoshihiro Shimizu, Hiroshi Abe

    Chemical Communications   Vol. 56 ( 46 ) page: 6217 - 6220   2020.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry ({RSC})  

    DOI: 10.1039/d0cc02140g

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  23. SYNTHESIS AND BIOLOGICAL EVALUATION OF NMDI14 DERIVATIVES AS ANTI-MESOTHELIOMA AGENTS Reviewed

    Hong Nhung Nguyen, Suzuki Koya, Kimura Yasuaki, Hirokawa Takatsugu, Murakami-Tonami Yuko, Abe Hiroshi

    Heterocycles   Vol. 100 ( 2 ) page: 253 - 266   2020.1

  24. Quantification of native mRNA dynamics in living neurons using fluorescence correlation spectroscopy and reduction-triggered fluorescent probes Reviewed International journal

    Hirotaka Fujita, Ryota Oikawa, Mayu Hayakawa, Fumiaki Tomoike, Yasuaki Kimura, Hiroyuki Okuno, Yoshiki Hatashita, Carolina Fiallos Oliveros, Haruhiko Bito, Toshio Ohshima, Satoshi Tsuneda, Hiroshi Abe, Takafumi Inoue

    Journal of Biological Chemistry   Vol. in press   2020

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    Language:English   Publishing type:Research paper (scientific journal)  

  25. Intracellular delivery of Antisense DNA and siRNA with amino groups masked with disulfide units Reviewed

    Zhaoma Shu, Azumi Ota, Yukiya Takayama, Yuri Katsurada, Kosuke Kusamori, Naoko Abe, Kosuke Nakamoto, Fumiaki Tomoike, Seiichi Tada, Yoshihiro Ito, Makiya Nishikawa, Yasuaki Kimura, Hiroshi Abe

    Chemical and Pharmaceutical Bulletins     2020

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  26. Intracellular Build-up RNAi with Single-Strand Circular RNAs as siRNA Precursors Reviewed

    Yasuaki Kimura, Zhaoma Shu, Mika Ito, Naoko Abe, Kosuke Nakamoto, Fumiaki Tomoike, Satoshi Shuto, Yoshihiro Ito, Hiroshi Abe

    Chemical Communications     2020

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  27. Synthesis of 1,1,2-trisubstituted cyclopropane nucleosides in enantiomerically pure forms. Reviewed International journal

    Daichi Fushihara, Hayato Fukuda, Hiroshi Abe, Satoshi Shuto

    Nucleosides, nucleotides & nucleic acids   Vol. 38 ( 12 ) page: 921 - 941   2019.12

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    Due to the unique rigid and small steric feature of cyclopropane, cyclopropane nucleosides (CPNs) in which the ribose (deoxyribose) of nucleosides are replaced by a hydroxy-substituted cyclopropane, are of great biological interest. Novel 1,1,2-trisubstituted cyclopropane nucleosides were synthesized in enantiomerically pure forms as potential antiviral agents. In the synthesis, two cyclopropane tosylates, which were prepared from chiral cyclopropane lactones previously reported by us, were used effectively as common intermediates for the CPNs. These CPNs are also potentially useful as nucleoside units to incorporate into oligonucleotides in nucleic acids chemotherapy studies.

    DOI: 10.1080/15257770.2019.1625380

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  28. Translational contro by secondary-structure formation in mRNA in eukaryotic system Reviewed

    Daisuke Kawaguchi, Saaya Shimizu, Naoko Abe, Fumitaka Hashiya, Tomoike Fumiaki, Yasuaki Kimura, Hiroshi Abe

    Nucleosides, Nucleotides and Nucleic Acids     page: 1 - 9   2019.9

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  29. RNA imaging by chemical probes Invited Reviewed

    TOMOIKE Fumiaki, ABE Hiroshi

    Advanced Drug Delivery Reviews   Vol. 147   page: 44 - 58   2019.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.addr.2019.08.001

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  30. Disulfide‐Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA Reviewed

    Zhaoma Shu, Iku Tanaka, Azumi Ota, Daichi Fushihara, Naoko Abe, Saki Kawaguchi, Kosuke Nakamoto, Fumiaki Tomoike, Seiichi Tada, Yoshihiro Ito, Yasuaki Kimura, Hiroshi Abe

    Angewandte Chemie   Vol. 131 ( 20 ) page: 6683   2019.5

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    Publisher:Wiley  

    DOI: 10.1002/ange.201900993

  31. ウイルスタンパク質の活性をトリガーとした新規不可逆阻害剤の開発 Reviewed

    福井 竜介, 新美 結士, 片倉 秀雄, 鈴木 哲郎, 村上 努, 児玉 栄一, 木村 康明, 阿部 洋

    日本薬学会年会要旨集   Vol. 139年会 ( 2 ) page: 103 - 103   2019.3

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    Language:Japanese   Publisher:(公社)日本薬学会  

  32. 膜透過性を有するGST共有結合性阻害剤の開発

    友池 史明, 宍戸 裕子, 藤川 遥加, 木村 康明, 桑田 啓子, 村上 優子, 福井 健二, 関戸 好孝, 矢野 貴人, 亀田 倫史, 周東 智, 阿部 洋

    日本薬学会年会要旨集   Vol. 139年会 ( 2 ) page: 80 - 80   2019.3

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  33. A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells Reviewed

    Yuko Shishido, Fumiaki Tomoike, Keiko Kuwata, Haruka Fujikawa, Yoshitaka Sekido, Yuko Murakami-Tonami, Tomoshi Kameda, Naoko Abe, Yasuaki Kimura, Satoshi Shuto, Hiroshi Abe

    ChemBioChem   Vol. 20   page: 900 - 905   2019

  34. N6-methyl adenosine in siRNA evades immune response without reducing RNAi activity Reviewed

    Akihiro Imaeda, Fumiaki Tomoike, Mayu Hayakawa, Kosuke Nakamoto, Yasuaki Kimura, Naoko Abe, Hiroshi Abe

    Nucleosides, Nucleotides and Nucleic Acids   Vol. 38   page: 6611 - 6615   2019

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  35. Disulfide‐unit conjugation enables ultrafast cytosolic internalization of antisense DNA and siRNA Reviewed

    Zhaoma Shu, Iku Tanaka, Azumi Ota, Daichi Fushihara, Naoko Abe, Saki Kawaguchi, Kosuke Nakamoto, Fumiaki Tomoike, Seiichi Tada, Yoshihiro Ito, Yasuaki Kimura, Hiroshi Abe

    Angewandte Chemie International Edition   Vol. 58   page: 6611 - 6615   2019

  36. Nearest-neighbor parameter for inosine-cytosine pairs through a combined experimental and computational approach Reviewed

    Shun Sakuraba, Junichi Iwakiri, Michiaki Hamada, Tomoshi Kameda, Genichiro Tsuji, Yasuaki Kimura, Hiroshi Abe, Kiyoshi Asai

        2018.10

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    Publisher:Cold Spring Harbor Laboratory  

    <title>Abstract</title>In RNA secondary structure prediction, nearest-neighbor parameters are used to determine the stability of a given structure. We derived the nearest-neighbor parameters for RNAs containing inosine-cytosine pairs. For parameter derivation, we developed a method that combines UV adsorption measurement experiments with free-energy calculations using molecular dynamics simulations. The method provides fast drop-in parameters for modified bases. Derived parameters were compared and found to be consistent with existing parameters for canonical RNAs. A duplex with an internal inosine-cytosine pair is 0.9 kcal/mol more unstable than the same duplex with an internal guanine-cytosine pair, and is as stable as the one with an internal adenine-uracil pair (only 0.1 kcal/mol more stable) on average.

    DOI: 10.1101/454124

  37. Chemical ligation reaction for oligonucleotides based on electrophilic phosphorothioester

    Kimura Yasuaki, Maruyama Hideto, Oikawa Ryota, Hayakawa Mayu, Abe Naoko, Tsuji Genichiro, Matsuda Akira, Shuto Satoshi, Ito Yoshihiro, Abe Hiroshi

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 255   page: .   2018.3

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  38. Nano structure design for RNA interference

    Shu Zhaoma, Abe Naoko, Tomoike Fumiaki, Kimura Yasuaki, Ito Yoshihiro, Abe Hiroshi

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 255   page: .   2018.3

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  39. Development of glutathione S-transferase (GST) covalent inhibitor

    Shishido Yuko, Tomoike Fumiaki, Kimura Yasuaki, Kuwata Keiko, Yano Takato, Fukui Kenji, Fujikawa Haruka, Sekido Yoshitaka, Murakami-Tonami Yuko, Kameda Tomoshi, Shuto Satoshi, Abe Hiroshi

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 255   page: .   2018.3

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  40. Chemical ligation reaction for oligonucleotides based on electrophilic phosphorothioester Reviewed

    Kimura Yasuaki, Maruyama Hideto, Oikawa Ryota, Hayakawa Mayu, Abe Naoko, Tsuji Genichiro, Matsuda Akira, Shuto Satoshi, Ito Yoshihiro, Abe Hiroshi

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 255   2018.3

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  41. Chemical Ligation Reactions of Oligonucleotides for Biological and Medicinal Applications

    Abe Hiroshi, Kimura Yasuaki

    CHEMICAL & PHARMACEUTICAL BULLETIN   Vol. 66 ( 2 ) page: 117-122   2018.2

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  42. Development of GST (Glutathione S-transferase) covalent inhibitor

    Shishido Yuko, Sekido Yoshitaka, Murakami-Tonami Yuko, Abe Hiroshi

    CANCER SCIENCE   Vol. 109   page: 374-374   2018.1

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  43. Preparation of circular RNA in vitro Reviewed

    Naoko Abe, Ayumi Kodama, Hiroshi Abe

    Methods in Molecular Biology   Vol. 1724   page: 181 - 192   2018

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    Language:Japanese   Publishing type:Part of collection (book)   Publisher:Humana Press Inc.  

    This chapter describes a simple and straightforward way to obtain single-stranded circular RNA sequences in vitro. Linear RNA that is phosphorylated at the 5′ end is first prepared by a chemical or enzymatic method, then circularized using ligase. The function of the prepared circular RNA molecule, such as an ability to induce translation, can then be investigated.

    DOI: 10.1007/978-1-4939-7562-4_15

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  44. Chemical Ligation Reactions of Oligonucleotides for Biological and Medicinal Applications

    Hiroshi Abe, Yasuaki Kimura

    Chemical and Pharmaceutical Bulletin   Vol. 66 ( 2 ) page: 117 - 122   2018

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Pharmaceutical Society of Japan  

    DOI: 10.1248/cpb.c17-00615

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  45. Structural optimization of pseudorotaxane-forming oligonucleotides for efficient and stable complex formation Reviewed

    Kazumitsu Onizuka, Takuya Miyashita, Tomoko Chikuni, Mamiko Ozawa, Hiroshi Abe, Fumi Nagatsugi

    Nucleic Acids Research   Vol. 46   page: 8710 - 8719   2018

  46. MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation Reviewed

    Lars Bräutigam, Jie Zhang, Kristian Dreij, Linda Spahiu, Arne Holmgren, Hiroshi Abe, Kenneth D. Tew, Danyelle M. Townsend, Michael J. Kelner, Ralf Morgenstern, Katarina Johansson

    Redox Biology   Vol. 17   page: 171 - 179   2018

  47. グルタチオン-S-トランスフェラーゼを標的とした共有結合性阻害剤の開発

    宍戸 裕子, 藤川 遥加, 友池 史明, 木村 康明, 桑田 啓子, 村上 優子, 福井 健二, 関戸 好孝, 矢野 貴人, 周東 智, 阿部 洋

    生命科学系学会合同年次大会   Vol. 2017年度   page: [3P - 0205]   2017.12

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    Language:Japanese   Publisher:生命科学系学会合同年次大会運営事務局  

  48. A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP(1-1)) Reviewed

    Yuko Shishido, Fumiaki Tomoike, Yasuaki Kimura, Keiko Kuwata, Takato Yano, Kenji Fukui, Haruka Fujikawa, Yoshitaka Sekido, Yuko Murakami-Tonami, Tomoshi Kameda, Satoshi Shuto, Hiroshi Abe

    CHEMICAL COMMUNICATIONS   Vol. 53 ( 81 ) page: 11138 - 11141   2017.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:ROYAL SOC CHEMISTRY  

    We herein report the first covalent G-site-binding inhibitor for GST, GS-ESF (1), which irreversibly inhibited the GSTP1-1 function. LC-MS/MS and X-ray structure analyses of the covalently linked GST-inhibitor complex suggested that 1 reacted with Tyr108 of GSTP1-1. The mechanism of covalent bond formation was discussed based on MD simulation results.

    DOI: 10.1039/c7cc05829b

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  49. Chemical ligation of oligonucleotides using an electrophilic phosphorothioester Reviewed

    Hideto Maruyama, Ryota Oikawa, Mayu Hayakawa, Shono Takamori, Yasuaki Kimura, Naoko Abe, Genichiro Tsuji, Akira Matsuda, Satoshi Shuto, Yoshihiro Ito, Hiroshi Abe

    Nucleic Acids Research   Vol. 45 ( 12 ) page: 7042-7048   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gkx459

  50. Chemical ligation of oligonucleotides using an electrophilic phosphorothioester

    Maruyama Hideto, Oikawa Ryota, Hayakawa Mayu, Takamori Shono, Kimura Yasuaki, Abe Naoko, Tsuji Genichiro, Matsuda Akira, Shuto Satoshi, Ito Yoshihiro, Abe Hiroshi

    NUCLEIC ACIDS RESEARCH   Vol. 45 ( 12 ) page: 7042-7048   2017.7

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    DOI: 10.1093/nar/gkx459

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  51. Tethered 1,2-Si-Group Migrations in Radical-Mediated Ring Enlargements of Cyclic Alkoxysilanes: An EPR Spectroscopic and Computational Investigation

    Walton John C., Kanada Ryutaro, Iwamoto Takeaki, Shuto Satoshi, Abe Hiroshi

    JOURNAL OF ORGANIC CHEMISTRY   Vol. 82 ( 13 ) page: 6886-6894   2017.7

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    DOI: 10.1021/acs.joc.7b01011

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  52. Enhancement of synergistic gene silencing by RNA interference using branched "3-in-1" trimer siRNA

    Nair Baiju G., Zhou Yue, Hagiwara Kyoji, Ueki Masashi, Isoshima Takashi, Abe Hiroshi, Ito Yoshihiro

    JOURNAL OF MATERIALS CHEMISTRY B   Vol. 5 ( 22 ) page: 4044-4051   2017.6

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    DOI: 10.1039/c7tb00846e

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  53. Tethered 1,2-Si-Group Migrations in Radical-Mediated Ring Enlargements of Cyclic Alkoxysilanes: An EPR Spectroscopic and Computational Investigation Reviewed

    John C. Walton*, Ryutaro Kanada, Takeaki Iwamoto, Satoshi Shuto, Hiroshi Abe

    Journal of Organic Chemistry   Vol. 82 ( 13 ) page: 6886-6894   2017.6

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    DOI: 10.1021/acs.joc.7b01011

  54. Pseudorotaxane formation via the slippage process with chemically cyclized oligonucleotides

    Onizuka Kazumitsu, Chikuni Tomoko, Amemiya Takuya, Miyashita Takuya, Onizuka Kyoko, Abe Hiroshi, Nagatsugi Fumi

    NUCLEIC ACIDS RESEARCH   Vol. 45 ( 9 ) page: 5036-5047   2017.5

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    DOI: 10.1093/nar/gkx265

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  55. Enhancement of synergistic gene silencing by RNA interference using branched “3-in-1” trimer siRNA Reviewed

      Vol. 5   page: 4044-4051   2017.5

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    DOI: 10.1039/C7TB00846E

  56. Pseudorotaxane formation via the slippage process with chemically cyclized oligonucleotides Reviewed

    Kazumitsu Onizuka, Tomoko Chikuni, Takuya Amemiya, Takuya Miyashita, Kyoko Onizuka, Hiroshi Abe, Fumi Nagatsugi

    Nucleic Acids Research   Vol. 45 ( 9 ) page: 5036-5047   2017.4

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    DOI: 10.1093/nar/gkx265

  57. Catalytic Conversion of Lipophilic Substrates by Phase constrained Enzymes in the Aqueous or in the Membrane Phase Reviewed

    Marcus Cebula. Ilke Simek Turan, Birgitta Sjodin, Madhuranayaki Thulasingam, Joseph Brock, Volodymyr Chmyrov, Jerker Widengren, Hiroshi Abe, Bengt Mannervik, Jesper Haeggstrom, Agnes Rinaldo-Matthis, Engin Akkaya, Ralf Morgenstern

    Scientific Reports   Vol. 6   page: 38316   2016.12

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  58. Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents Reviewed

    Hayato Fukuda, Ryuta Muromoto, Yuuki Takakura, Kohei Ishimura, Ryutaro Kanada, Daichi Fushihara, Makoto Tanabe, Kotaro Matsubara, Toru Hirao, Koki Hirashima, Hiroshi Abe, Mitsuhiro Arisawa, Tadashi Matsuda, Satoshi Shuto

    Organic Letters   Vol. 18   page: 6224-6227   2016.11

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  59. Chemical reactivity window determines prodrug efficiency towards glutathione transferase overexpressing cancer cells Reviewed

    Marie van Gisbergen, Marcus Cebula, Jie Zhang, Astrid Ottosson-Wadlund, Ludwig Dubois, Philippe Lambin, Kenneth D. Tew, Danyelle Townsend, Guido Haenen, Marie-Jose Drittij-Reijnders, Hisao Saneyoshi, Mika Araki, Yuko Shishido, Yoshihiro Ito, Elias Arner, Hiroshi Abe, Ralf Morgenstern, Katarina Johansson

    Molecular Pharmaceutics   Vol. 13   page: 2010-2025   2016.4

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  60. Diastereoselective Synthesis of 6"-(Z)- and (E) -Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers

    Hiroki Kumamoto, Misato Fukano, Tomohiko Nakano, Keito Iwagami, Chiaki Takeyama, Satoru Kohgo, Shuhei Imoto, Masayuki Amano, Nobuyo Kuwata-Higashi, Manabu Aoki,Hiroshi Abe, Hiroaki Mitsuya, Kiyoshi Fukuhara, Kazuhiro Haraguchi

    The Journal of Organinic Chemistry   Vol. 81 ( 7 ) page: 2827   2016.3

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    DOI: 10.1021

  61. Rolling Circle Translation of Circular of Circular RNA in Living Human Cells

    Naoko Abe, Ken Matsumoto, Mizuki Nishihara, Yukiko Nakano, Aya Shibata, Hideto Maruyama, Satoshi Shuto, Akira Matsuda, Minoru Yoshida, Yoshihiro Ito, Horoshi Abe

    Scientific Reports     2015.11

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    DOI: 10.1038

  62. Phosphorylated 5-ethynyl-2'-deoxyuridine for advanced DNA labeling. Reviewed

    Seo S, Onizuka K, Nishioka C, Takahashi E, Tsuneda S, Abe H, Ito Y

    Organic & biomolecular chemistry   Vol. 13 ( 15 ) page: 4589-95   2015.3

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    DOI: 10.1039/c5ob00199d

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  63. Nanostructured RNAs for RNA interference. Reviewed

    Nakashima Y, Abe N, Ito Y, Abe H

    Methods in molecular biology (Clifton, N.J.)   Vol. 1218   page: 17-36   2015

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    DOI: 10.1007/978-1-4939-1538-5_2

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  64. Synthesis of 3',4'-difluoro-3'-deoxyribonucleosides and its evaluation of the biological activities: discovery of a novel type of anti-HCV agent 3',4'-difluorocordycepin. Reviewed

    Shimada H, Haraguchi K, Hotta K, Miyaike T, Kitagawa Y, Tanaka H, Kaneda R, Abe H, Shuto S, Mori K, Ueda Y, Kato N, Snoeck R, Andrei G, Balzarini J

    Bioorganic & medicinal chemistry   Vol. 22 ( 21 ) page: 6174-82   2014.11

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    DOI: 10.1016/j.bmc.2014.08.024

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  65. Automatic Pseudorotaxane Formation Targeting on Nucleic Acids Using a Pair of Reactive Oligodeox-ynucleotides Reviewed

    Kazumitsu Onizuka, Fumi Nagatsugi, Yoshihiro Ito, Hiroshi Abe

    Journal of the American Chemical Society   Vol. 136 ( 20 ) page: 7201-7204   2014.5

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    DOI: 10.1021/ja5018283

  66. Transmembrane molecular transport through nanopores formed by protein nanotubes. Reviewed

    Nair BG, Nakano Y, Ito Y, Abe H

    Chemical communications (Cambridge, England)   Vol. 50 ( 5 ) page: 602-4   2014.1

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    DOI: 10.1039/c3cc45907a

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  67. Triphenylphosphinecarboxamide: an effective reagent for the reduction of azides and its application to nucleic acid detection. Reviewed

    Saneyoshi H, Ochikubo T, Mashimo T, Hatano K, Ito Y, Abe H

    Organic letters   Vol. 16 ( 1 ) page: 30-3   2014.1

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    DOI: 10.1021/ol402832w

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  68. グルタチオントランスフェラーゼを標的とした分子プローブの開発

    伊藤美香,周東智,伊藤嘉浩,阿部洋

    有機合成化学教会誌     page: 822   2014

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  69. 非酵素的に高効率シグナル増幅を可能とする新規RNA検出法を開発

    柴田綾、鵜澤尊規、伊藤嘉浩、周東智、阿部洋

    化学と生物   Vol. 52 ( 11 ) page: 771-776   2014

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  70. Nanostructured RNAs for RNA interference

    Yuko Nakashima, Naoko Abe, Yoshihiro Ito, Hiroshi Abe

    Humana Press New York     page: 全   2014

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  71. Polycation-assisted DNA detection by reduction triggered fluorescence amplification probe. Reviewed

    Saneyoshi H, Shimada N, Maruyama A, Ito Y, Abe H

    Bioorganic & medicinal chemistry letters   Vol. 23 ( 24 ) page: 6851-3   2013.12

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    DOI: 10.1016/j.bmcl.2013.10.005

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  72. An epidermal growth factor derivative with binding affinity for hydroxyapatite and titanium surfaces. Reviewed

    Kang J, Tada S, Sakuragi M, Abe H, Ito R, Ishikawa J, Kurata S, Kitajima T, Son TI, Aigaki T, Ito Y

    Biomaterials   Vol. 34 ( 38 ) page: 9747-53   2013.12

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    DOI: 10.1016/j.biomaterials.2013.09.004

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  73. Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions. Reviewed

    Shibata A, Nakano Y, Ito M, Araki M, Zhang J, Yoshida Y, Shuto S, Mannervik B, Morgenstern R, Ito Y, Abe H

    The Analyst   Vol. 138 ( 24 ) page: 7326-30   2013.11

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    DOI: 10.1039/c3an01339a

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  74. Very rapid DNA-templated reaction for efficient signal amplification and its steady-state kinetic analysis of the turnover cycle. Reviewed

    Shibata A, Uzawa T, Nakashima Y, Ito M, Nakano Y, Shuto S, Ito Y, Abe H

    Journal of the American Chemical Society   Vol. 135 ( 38 ) page: 14172-8   2013.9

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    DOI: 10.1021/ja404743m

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  75. Long-lived luminogenic probe for detection of RNA in a crude solution of living bacterial cells. Reviewed

    Saneyoshi H, Ito Y, Abe H

    Journal of the American Chemical Society   Vol. 135 ( 37 ) page: 13632-5   2013.9

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    DOI: 10.1021/ja406724k

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  76. Rolling circle amplification in a prokaryotic translation system using small circular RNA. Reviewed

    Abe N, Hiroshima M, Maruyama H, Nakashima Y, Nakano Y, Matsuda A, Sako Y, Ito Y, Abe H

    Angewandte Chemie (International ed. in English)   Vol. 52 ( 27 ) page: 7004-8   2013.7

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    DOI: 10.1002/anie.201302044

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  77. Sustained delivery of siRNA from dopamine-coated stainless steel surfaces. Reviewed

    Joddar B, Albayrak A, Kang J, Nishihara M, Abe H, Ito Y

    Acta biomaterialia   Vol. 9 ( 5 ) page: 6753-61   2013.5

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    DOI: 10.1016/j.actbio.2013.01.007

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  78. Cationic cholesterol-modified gelatin as an in vitro siRNA delivery vehicle. Reviewed

    Kadengodlu PA, Aigaki T, Abe H, Ito Y

    Molecular bioSystems   Vol. 9 ( 5 ) page: 965-8   2013.5

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    DOI: 10.1039/c2mb25424g

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  79. One-pot ring-closing metathesis/1,3-dipolar cycloaddition through assisted tandem ruthenium catalysis: synthesis of a dye with isoindolo[2,1-a]quinoline structure. Reviewed

    Arisawa M, Fujii Y, Kato H, Fukuda H, Matsumoto T, Ito M, Abe H, Ito Y, Shuto S

    Angewandte Chemie (International ed. in English)   Vol. 52 ( 3 ) page: 1003-7   2013.1

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    DOI: 10.1002/anie.201206765

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  80. RNA-templated molecule release induced protein expression in bacterial cells. Reviewed

    Shibata A, Ito Y, Abe H

    Chemical communications (Cambridge, England)   Vol. 49 ( 3 ) page: 270-2   2013.1

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    DOI: 10.1039/c2cc37826d

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  81. Triphenylphosphinecarboxamide: An Effective Reagent for the Reduction of Azides and its Application to Nucleic Acid Detection Reviewed

    Hisao Saneyoshia, Tatsuya Ochikuboa, Takushi Mashimoa, Ken Hatano, Yoshihiro Ito, Hiroshi Abe

    Organic Letters   Vol. 16 ( 1 ) page: 30-33   2013.1

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    DOI: 10.1021/ol402832w

  82. ナノ構造化RNAを用いたRNA干渉法

    阿部洋

    薬学雑誌   Vol. 133 ( 3 ) page: 373-378   2013

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  83. 有機溶媒に溶ける核酸ーDNA触媒の新たな可能性」

    阿部洋

    現代化学   ( 1月 )   2013

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    DOI: 0

  84. "PEGylated Antibodies and DNA in Organic Media and Genetic PEGylation" in "Green Polymer 2"

    Seiichi Tada, Horoshi Abe, and Yoshihiro Ito

    American Chemical Society     page: 223-233   2013

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  85. In vitro selection of a photo-responsive peptide aptamer using ribosome display. Reviewed

    Liu M, Tada S, Ito M, Abe H, Ito Y

    Chemical communications (Cambridge, England)   Vol. 48 ( 97 ) page: 11871-3   2012.12

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    DOI: 10.1039/c2cc36618e

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  86. Detection of pre-mRNA splicing in vitro by an RNA-templated fluorogenic reaction. Reviewed

    Tamura Y, Furukawa K, Yoshimoto R, Kawai Y, Yoshida M, Tsuneda S, Ito Y, Abe H

    Bioorganic & medicinal chemistry letters   Vol. 22 ( 23 ) page: 7248-51   2012.12

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    DOI: 10.1016/j.bmcl.2012.09.033

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  87. Tuning efficiency of the 4-exo-trig cyclization by the electronic effect: ring closure of 3,3-difluoro-4-pentenyl carbon radicals and synthesis of a gem-difluorocyclobutane nucleoside. Reviewed

    Kumamoto H, Kawahigashi S, Wakabayashi H, Nakano T, Miyaike T, Kitagawa Y, Abe H, Ito M, Haraguchi K, Balzarini J, Baba M, Tanaka H

    Chemical communications (Cambridge, England)   Vol. 48 ( 89 ) page: 10993-5   2012.11

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    DOI: 10.1039/c2cc35876j

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  88. ナノ構造を制御したRNA干渉法

    阿部洋、阿部奈保子、柴田綾、伊藤嘉浩

    アンチセンスDNA/RNA研究会誌   Vol. 16 ( 2 ) page: 3   2012.11

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  89. Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity. Reviewed

    Arisawa M, Kasaya Y, Obata T, Sasaki T, Nakamura T, Araki T, Yamamoto K, Sasaki A, Yamano A, Ito M, Abe H, Ito Y, Shuto S

    Journal of medicinal chemistry   Vol. 55 ( 18 ) page: 8152-63   2012.9

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    DOI: 10.1021/jm301084z

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  90. Universal caging group for the in-cell detection of glutathione transferase applied to 19F NMR and bioluminogenic probes. Reviewed

    Ito M, Shibata A, Zhang J, Hiroshima M, Sako Y, Nakano Y, Kojima-Aikawa K, Mannervik B, Shuto S, Ito Y, Morgenstern R, Abe H

    Chembiochem : a European journal of chemical biology   Vol. 13 ( 10 ) page: 1428-32   2012.7

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    DOI: 10.1002/cbic.201200242

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  91. 環元反応を引き金とするoff/on 型蛍光プローブを用いたRNA検出法の開発

    阿部洋、柴田綾、古川和寛、常田聡、伊藤嘉浩

    化学と生物   Vol. 50 ( 7月 ) page: 540   2012.7

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  92. Structure formation and catalytic activity of DNA dissolved in organic solvents. Reviewed

    Abe H, Abe N, Shibata A, Ito K, Tanaka Y, Ito M, Saneyoshi H, Shuto S, Ito Y

    Angewandte Chemie (International ed. in English)   Vol. 51 ( 26 ) page: 6475-9   2012.6

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    DOI: 10.1002/anie.201201111

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  93. Synthesis of dumbbell-shaped cyclic RNAs for RNA interference. Reviewed

    Abe N, Abe H, Ito Y

    Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]   Vol. Chapter 16   page: Unit 16.4.1-11   2012.3

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    DOI: 10.1002/0471142700.nc1604s48

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  94. Oligonucleotide-templated reactions for sensing nucleic acids. Reviewed

    Shibata A, Abe H, Ito Y

    Molecules (Basel, Switzerland)   Vol. 17 ( 3 ) page: 2446-63   2012.2

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    DOI: 10.3390/molecules17032446

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  95. Positively charged cholesterol-recombinant human gelatins foster the cellular uptake of proteins and murine immune reactions. Reviewed

    Kadengodlu PA, Hebishima T, Takeshima SN, Ito M, Liu M, Abe H, Aida Y, Aigaki T, Ito Y

    International journal of nanomedicine   Vol. 7   page: 5437-50   2012

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    DOI: 10.2147/IJN.S36350

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  96. Synthesis of Dumbbell-Shaped Cyclic RNAs for RNA Interference

    Naoko Abe, Hiroshi Abe, Yoshihiro Ito

    Current Protocol Nucleic Acid Chemistry     page: 1-16   2012

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  97. Fluorescence detection of intron lariat RNA with reduction-triggered fluorescent probes. Reviewed

    Furukawa K, Abe H, Tamura Y, Yoshimoto R, Yoshida M, Tsuneda S, Ito Y

    Angewandte Chemie (International ed. in English)   Vol. 50 ( 50 ) page: 12020-3   2011.12

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    DOI: 10.1002/anie.201104425

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  98. Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference. Reviewed

    Abe N, Abe H, Nagai C, Harada M, Hatakeyama H, Harashima H, Ohshiro T, Nishihara M, Furukawa K, Maeda M, Tsuneda S, Ito Y

    Bioconjugate chemistry   Vol. 22 ( 10 ) page: 2082-92   2011.10

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    DOI: 10.1021/bc2003154

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  99. Characterization of new potential anticancer drugs designed to overcome glutathione transferase mediated resistance. Reviewed

    Johansson K, Ito M, Schophuizen CM, Mathew Thengumtharayil S, Heuser VD, Zhang J, Shimoji M, Vahter M, Ang WH, Dyson PJ, Shibata A, Shuto S, Ito Y, Abe H, Morgenstern R

    Molecular pharmaceutics   Vol. 8 ( 5 ) page: 1698-708   2011.10

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    DOI: 10.1021/mp2000692

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  100. Synthesis of 4'-Ethynyl-2'-deoxy-4'-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI. Reviewed

    Haraguchi K, Shimada H, Kimura K, Akutsu G, Tanaka H, Abe H, Hamasaki T, Baba M, Gullen EA, Dutschman GE, Cheng YC, Balzarini J

    ACS medicinal chemistry letters   Vol. 2 ( 9 ) page: 692-697   2011.9

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    DOI: 10.1021/ml2001054

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  101. Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy. Reviewed

    Zhang J, Shibata A, Ito M, Shuto S, Ito Y, Mannervik B, Abe H, Morgenstern R

    Journal of the American Chemical Society   Vol. 133 ( 35 ) page: 14109-19   2011.9

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    DOI: 10.1021/ja205500y

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  102. Branched RNA nanostructures for RNA interference. Reviewed

    Nakashima Y, Abe H, Abe N, Aikawa K, Ito Y

    Chemical communications (Cambridge, England)   Vol. 47 ( 29 ) page: 8367-9   2011.8

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    DOI: 10.1039/c1cc11780g

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  103. Indomethacin Analogues that Enhance Doxorubicin Cytotoxicity in Multidrug Resistant Cells without Cox Inhibitory Activity. Reviewed

    Arisawa M, Kasaya Y, Obata T, Sasaki T, Ito M, Abe H, Ito Y, Yamano A, Shuto S

    ACS medicinal chemistry letters   Vol. 2 ( 5 ) page: 353-7   2011.5

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    DOI: 10.1021/ml100292y

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  104. PEGylated antibody in organic media. Reviewed

    Liu M, Xu M, Loh XJ, Abe H, Tsumuraya T, Fujii I, Li J, Son TI, Ito Y

    Journal of bioscience and bioengineering   Vol. 111 ( 5 ) page: 564-8   2011.5

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    DOI: 10.1016/j.jbiosc.2011.01.001

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  105. Synthesis and characterization of small circular double-stranded RNAs. Reviewed

    Abe N, Abe H, Ohshiro T, Nakashima Y, Maeda M, Ito Y

    Chemical communications (Cambridge, England)   Vol. 47 ( 7 ) page: 2125-7   2011.2

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    DOI: 10.1039/c0cc04551a

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  106. 進化分子工学による高分子触媒合成と生体高分子のハイブリット化

    劉明哲、阿部洋、伊藤嘉浩

    高分子論文集   Vol. 68 ( 7 ) page: 405-416   2011

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  107. Photoactivatable fluorescein derivatives with azidomethyl caging groups for tracing oligonucleotides in living human cells. Reviewed

    Furukawa K, Abe H, Tsuneda S, Ito Y

    Organic & biomolecular chemistry   Vol. 8 ( 10 ) page: 2309-11   2010.5

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    DOI: 10.1039/b926100a

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  108. In vitro selection of a photoresponsive RNA aptamer to hemin. Reviewed

    Liu M, Jinmei H, Abe H, Ito Y

    Bioorganic & medicinal chemistry letters   Vol. 20 ( 9 ) page: 2964-7   2010.5

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    DOI: 10.1016/j.bmcl.2010.02.109

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  109. Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands. Reviewed

    Kobayashi T, Watanabe M, Yoshida A, Yamada S, Ito M, Abe H, Ito Y, Arisawa M, Shuto S

    Bioorganic & medicinal chemistry   Vol. 18 ( 3 ) page: 1076-82   2010.2

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    DOI: 10.1016/j.bmc.2009.12.046

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  110. Hemin-Binding Aptamers and Aptazymes

    Mingahe Liu, Horoshi Abe, Yoshihiro Ito

    ACS Symposium Series 1043(Green Polymer Chemistry)     page: 111-123   2010

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  111. DNA templated nucleophilic aromatic substitution reactions for fluorogenic sensing of oligonucleotides. Reviewed

    Shibata A, Abe H, Ito M, Kondo Y, Shimizu S, Aikawa K, Ito Y

    Chemical communications (Cambridge, England)   ( 43 ) page: 6586-8   2009.11

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    DOI: 10.1039/b912896d

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  112. Reduction-triggered fluorescence probe for peptide-templated reactions. Reviewed

    Shibata A, Abe H, Furukawa K, Tsuneda S, Ito Y

    Chemical & pharmaceutical bulletin   Vol. 57 ( 11 ) page: 1223-6   2009.11

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  113. Characterization of a new fluorogenic substrate for microsomal glutathione transferase 1. Reviewed

    Analytical biochemistry   Vol. 390 ( 1 ) page: 52-6   2009.7

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    DOI: 10.1016/j.ab.2009.03.046

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  114. Reduction-triggered fluorescent amplification probe for the detection of endogenous RNAs in living human cells. Reviewed

    Furukawa K, Abe H, Hibino K, Sako Y, Tsuneda S, Ito Y

    Bioconjugate chemistry   Vol. 20 ( 5 ) page: 1026-36   2009.5

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    DOI: 10.1021/bc900040t

    PubMed

  115. In vitro selection of hemin-binding catalytic RNA. Reviewed

    Liu M, Kagahara T, Abe H, Ito Y

    Bioorganic & medicinal chemistry letters   Vol. 19 ( 5 ) page: 1484-7   2009.3

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    DOI: 10.1016/j.bmcl.2009.01.016

    PubMed

  116. 細胞機能制御高分子と再生医療高分子

    伊藤嘉浩、北嶋隆、阿部洋

    細胞機能制御高分子と再生医療高分子   Vol. 58 ( 3月 ) page: 全   2009.3

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  117. Reduction-triggered red fluorescent probes for dual-color detection of oligonucleotide sequences. Reviewed

    Furukawa K, Abe H, Wang J, Uda M, Koshino H, Tsuneda S, Ito Y

    Organic & biomolecular chemistry   Vol. 7 ( 4 ) page: 671-7   2009.2

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    DOI: 10.1039/b817228e

    PubMed

  118. Protein detection using oligonucleotide probes. Reviewed

    Shibata A, Abe H, Furukawa K, Tsuneda S, Ito Y

    Nucleic acids symposium series (2004)   ( 53 ) page: 157-8   2009

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    DOI: 10.1093/nass/nrp079

    PubMed

  119. Synthetic nanocircular RNA for controlling of gene expression. Reviewed

    Abe H, Abe N, Uda M, Tsuneda S, Ito Y

    Nucleic acids symposium series (2004)   ( 53 ) page: 65-6   2009

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    DOI: 10.1093/nass/nrp033

    PubMed

  120. Fluorescence generation from tandem repeats of a malachite green RNA aptamer using rolling circle transcription. Reviewed

    Furukawa K, Abe H, Abe N, Harada M, Tsuneda S, Ito Y

    Bioorganic & medicinal chemistry letters   Vol. 18 ( 16 ) page: 4562-5   2008.8

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    DOI: 10.1016/j.bmcl.2008.07.040

    PubMed

  121. A reduction-triggered fluorescence probe for sensing nucleic acids. Reviewed

    Abe H, Wang J, Furukawa K, Oki K, Uda M, Tsuneda S, Ito Y

    Bioconjugate chemistry   Vol. 19 ( 6 ) page: 1219-26   2008.6

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    DOI: 10.1021/bc800014d

    PubMed

  122. Rhodamine-based fluorogenic probe for imaging biological thiol. Reviewed

    Shibata A, Furukawa K, Abe H, Tsuneda S, Ito Y

    Bioorganic & medicinal chemistry letters   Vol. 18 ( 7 ) page: 2246-9   2008.4

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    DOI: 10.1016/j.bmcl.2008.03.014

    PubMed

  123. Rapid DNA chemical ligation for amplification of RNA and DNA signal. Reviewed

    Abe H, Kondo Y, Jinmei H, Abe N, Furukawa K, Uchiyama A, Tsuneda S, Aikawa K, Matsumoto I, Ito Y

    Bioconjugate chemistry   Vol. 19 ( 1 ) page: 327-33   2008.1

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    DOI: 10.1021/bc700244s

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  124. In vitro selection of RNA aptamer to hemin. Reviewed

    Liu M, Kagahara T, Abe H, Ito Y

    Nucleic acids symposium series (2004)   ( 52 ) page: 513-4   2008

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    DOI: 10.1093/nass/nrn260

    PubMed

  125. Quenched autoligation probes. Reviewed

    Silverman AP, Abe H, Kool ET

    Methods in molecular biology (Clifton, N.J.)   Vol. 429   page: 161-70   2008

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    DOI: 10.1007/978-1-60327-040-3_11

    PubMed

  126. Fluorogenic probe triggered by reduction for nucleic acids sensing. Reviewed

    Furukawa K, Abe H, Wang J, Oki K, Uda M, Tsuneda S, Ito Y

    Nucleic acids symposium series (2004)   ( 52 ) page: 353-4   2008

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    DOI: 10.1093/nass/nrn178

    PubMed

  127. Nanocircular RNAs for RNA interference. Reviewed

    Abe H, Abe N, Harada M, Tsuneda S, Ito Y

    Nucleic acids symposium series (2004)   ( 52 ) page: 505-6   2008

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    DOI: 10.1093/nass/nrn256

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  128. ピラノースの配座制御に基づく立体選択的グリコシル化反応

    周東智、市川聡、阿部洋、松田彰

    有機合成化学協会誌     page: 50-60   2008

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  129. ダンベル型ナノサークルRNAでRNA干渉を長期安定に

    阿部洋、阿部奈保子、原田充、常田聡、伊藤嘉浩

    バイオインダストリー協会   Vol. 66 ( 8 ) page: 全   2008

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  130. Design and synthesis of biorelated polymers by combinatorial bioengineering

    Yoshihiro Ito, Hiroshi Abe, Akira Wada, Mingahe Liu

    ACS Symposium Series999(Polymer Biocatalysis and Biomaterials 2 )     page: 194-215   2008

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  131. 細胞内遺伝子シグナルの解析

    阿部洋、古川和寛、常田聡、伊藤嘉浩

    生物工学、日本生物工学会   Vol. 86 ( 6 ) page: 268-270   2008

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  132. Quenched autoligation probes

    Adam P. Silverman, Hiroshi Abe, Eric T. Kool

    Methods in Molecular Biology     page: 161-170   2008

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  133. Dumbbell-shaped nanocircular RNAs for RNA interference. Reviewed

    Abe N, Abe H, Ito Y

    Journal of the American Chemical Society   Vol. 129 ( 49 ) page: 15108-9   2007.12

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    DOI: 10.1021/ja0754453

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  134. [Bioprobe for imaging RNA in living cells]. Reviewed

    Abe H, Furukawa K, Tsuneda S, Ito Y

    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   Vol. 52 ( 13 Suppl ) page: 1619-24   2007.10

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    PubMed

  135. Intermolecular transfer of aminoacylated adenosine towards chemical aminoacylation of tRNA. Reviewed

    Liu M, Jinmei H, Fukuzono K, Abe H, Ito Y

    Nucleic acids symposium series (2004)   ( 51 ) page: 365-6   2007

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    DOI: 10.1093/nass/nrm183

    PubMed

  136. Multiple chemical ligation under thermal cycle. Reviewed

    Kondo Y, Abe H, Jinmei H, Abe N, Aikawa K, Matsumoto I, Ito Y

    Nucleic acids symposium series (2004)   ( 51 ) page: 353-4   2007

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    DOI: 10.1093/nass/nrm177

    PubMed

  137. Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands. Reviewed

    Mochizuki T, Kondo Y, Abe H, Tovey SC, Dedos SG, Taylor CW, Paul M, Potter BV, Matsuda A, Shuto S

    Journal of medicinal chemistry   Vol. 49 ( 19 ) page: 5750-8   2006.9

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    DOI: 10.1021/jm060310d

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  138. Design and synthesis of 5'-deoxy-5'-phenyladenophostin A, a highly potent IP3 receptor ligand. Reviewed

    Mochizuki T, Kondo Y, Abe H, Taylor CW, Potter BV, Matsuda A, Shuto S

    Organic letters   Vol. 8 ( 7 ) page: 1455-8   2006.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ol0602710

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  139. A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of beta-C-glucoside trisphosphates based on the conformational restriction strategy. Reviewed

    Terauchi M, Abe H, Tovey SC, Dedos SG, Taylor CW, Paul M, Trusselle M, Potter BV, Matsuda A, Shuto S

    Journal of medicinal chemistry   Vol. 49 ( 6 ) page: 1900-9   2006.3

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    DOI: 10.1021/jm051039n

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  140. Flow cytometric detection of specific RNAs in native human cells with quenched autoligating FRET probes. Reviewed

    Abe H, Kool ET

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 103 ( 2 ) page: 263-8   2006.1

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    DOI: 10.1073/pnas.0509938103

    PubMed

  141. Structure analysis of oligonucleotide in organic solvent. Reviewed

    Abe H, Abe N, Ito Y

    Nucleic acids symposium series (2004)   ( 50 ) page: 25-6   2006

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    DOI: 10.1093/nass/nrl013

    PubMed

  142. 新機能性核酸・タンパク質を生み出すコンビナトリアル・バイオエンジニアリング

    阿部洋、和田章、伊藤嘉浩

    生物工学会誌   Vol. 84 ( 8 ) page: 309   2006

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  143. Universal linkers for signal amplification in auto-ligating probes. Reviewed

    Abe H, Kool ET

    Nucleic acids symposium series (2004)   ( 49 ) page: 37-8   2005

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    DOI: 10.1093/nass/49.1.37

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  144. Highly stereoselective grignard addition to cis-substituted C-cyclopropylaldonitrones. The bisected s-trans transition state can be stabilized effectively by the Lewis acid-coordination. Reviewed

    Kazuta Y, Abe H, Matsuda A, Shuto S

    The Journal of organic chemistry   Vol. 69 ( 26 ) page: 9143-50   2004.12

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    DOI: 10.1021/jo048637e

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  145. Destabilizing universal linkers for signal amplification in self-ligating probes for RNA. Reviewed

    Abe H, Kool ET

    Journal of the American Chemical Society   Vol. 126 ( 43 ) page: 13980-6   2004.11

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    DOI: 10.1021/ja046791c

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  146. An efficient synthesis of beta-C-glycosides based on the conformational restriction strategy: Lewis acid promoted silane reduction of the anomeric position with complete stereoselectivity. Reviewed

    Terauchi M, Abe H, Matsuda A, Shuto S

    Organic letters   Vol. 6 ( 21 ) page: 3751-4   2004.10

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    DOI: 10.1021/ol048525+

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  147. Quenched auto-ligating DNAs: multicolor identification of nucleic acids at single nucleotide resolution. Reviewed

    Sando S, Abe H, Kool ET

    Journal of the American Chemical Society   Vol. 126 ( 4 ) page: 1081-7   2004.2

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    DOI: 10.1021/ja038665z

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  148. Construction of a cis-cyclopropane via reductive radical decarboxylation. Enantioselective synthesis of cis- and trans-1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents. Reviewed

    Yamaguchi K, Kazuta Y, Abe H, Matsuda A, Shuto S

    The Journal of organic chemistry   Vol. 68 ( 24 ) page: 9255-62   2003.11

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    DOI: 10.1021/jo0302206

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  149. A study on the conformation-anomeric effect-stereoselectivity relationship in anomeric radical reactions, using conformationally restricted glucose derivatives as substrates. Reviewed

    Abe H, Terauchi M, Matsuda A, Shuto S

    The Journal of organic chemistry   Vol. 68 ( 19 ) page: 7439-47   2003.9

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    DOI: 10.1021/jo030128+

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  150. A systematic study of the hydride reduction of cyclopropyl ketones with structurally simplified substrates. highly stereoselective reductions of trans-substituted cyclopropyl ketones via the bisected s-cis conformation. Reviewed

    Kazuta Y, Abe H, Yamamoto T, Matsuda A, Shuto S

    The Journal of organic chemistry   Vol. 68 ( 9 ) page: 3511-21   2003.5

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    DOI: 10.1021/jo030019v

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  151. Control of alpha/beta stereoselectivity in Lewis acid promoted C-glycosidations using a controlling anomeric effect based on the conformational restriction strategy. Reviewed

    Tamura S, Abe H, Matsuda A, Shuto S

    Angewandte Chemie (International ed. in English)   Vol. 42 ( 9 ) page: 1021-3   2003.3

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    DOI: 10.1002/anie.200390261

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  152. Synthesis and biological activity of adenophostin derivatives as IP3 receptor ligands. Reviewed

    Shuto S, Mochizuki T, Abe H, Kondo Y, Matsuda A

    Nucleic acids research. Supplement (2001)   ( 2 ) page: 23-4   2002

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    PubMed

  153. Development of new radical reactions with a vinylsilyl group and their application to the synthesis of branched-chain sugar nucleosides

    Satoshi Shuto, Maki kanazaki, Isamu Sugimoto, Satoshi Ichikawa, Yuki Nagasawa, Yoshihito Ueno, Hiroshi Abe, Noriaki Minakawa, Makoto Sukeda, Tetsuya Kodama, Makoto Nomura, Akira matsuda

    Recent Advances in Nucleosides     page: 21-55   2002

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  154. Intracellular Ca2+-mobilizing adenine nucleotides. Synthesis and biological activity of cyclic ADP-carbocyclic-ribose and C-glycosidic analog of adenophostin A

        page: 461-470   2001

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Books 10

  1. RNA干渉医薬の実現に向けた新手法の開発

    阿部洋、木村康明( Role: Joint author)

    2017 

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    Language:Japanese

  2. RNA干渉医薬の実現に向けた新手法の開発

    Biophilia  2017 

  3. 環状RNAの合成とその翻訳反応 – 大腸菌と動物細胞の翻訳系

    阿部洋、阿部奈保子( Role: Joint author)

    羊土社  2016 

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    Language:Japanese

  4. 「有機溶媒に溶ける核酸―DNA触媒の新たな可能性」

    阿部洋( Role: Sole author)

    東京化学同人  2013.1 

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    Language:Japanese

  5. 「生細胞内RNA検出のための化学反応プローブ」「難培養微生物研究の最新技術2〜ゲノム解析を中心とした最前線と将来展望〜」

    古川和寛,阿部洋,伊藤嘉浩,常田聡( Role: Joint author)

    シーエムシー出版  2010 

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  6. 終わりのない核酸の話ケミカルバイオロジー入門

    阿部洋( Role: Sole author)

    オーム社  2008.9 

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  7. 細胞内RNA可視化のためのバイオプローブ蛋白質 核酸 酵素

    阿部洋,古川和寛,常田聡,伊藤嘉浩( Role: Joint author)

    共立出版株式会社  2007 

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    Language:Japanese

  8. 細胞内遺伝子発現検出用の蛍光バイオプロープの設計と合成「ー細胞内定量解析の最前線」

    阿部洋,古川和寛,常田聡,伊藤嘉浩( Role: Joint author)

    シーエムシー出版  2007 

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  9. 抗体医薬の最前線

    和田章,阿部洋,伊藤嘉浩( Role: Joint author)

    シーエムシー出版  2007 

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  10. バイオプロープを用いたイメージング法とチップ解析法「ナノオプティクス・ナノフォトニクスのすべて」

    阿部洋,伊藤嘉浩( Role: Joint author)

    フロンティア出版  2006 

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MISC 11

  1. Synthesis of 1,1,2-Trisubstituted Cyclopropane Nucleosides in Enantiomerically Pure Forms (vol 38, pg 921, 2019)

    Daichi Fushihara, Hayato Fukuda, Hiroshi Abe, Satoshi Shuto

    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS   Vol. 39 ( 1-3 ) page: 471 - 471   2020.2

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    Language:English   Publisher:TAYLOR & FRANCIS INC  

    DOI: 10.1080/15257770.2020.1736777

    Web of Science

  2. Disulfide-unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA

    Nakamoto Kosuke, Shu Zhaoma, Abe Hiroshi

    Journal of Synthetic Organic Chemistry, Japan   Vol. 78 ( 5 ) page: 456 - 464   2020

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    <p>Oligonucleotide-based therapeutics are expected as novel therapeutic modalities, because they have a strong potential to cure the diseases which could not be targeted by conventional low-molecular-weight drugs. However, oligonucleotide has a polyanion structure derived from a phosphodiester backbone and thus, it cannot penetrate cell membranes. To develop the oligonucleotides-based therapeutics, this extremely low membrane permeability should be improved. In this study, we focused on the disulfide modification of oligonucleotides. Several disulfide derivatives are known to show efficient cellular uptake triggered by disulfide exchanging reaction with thiol group of membrane proteins. Therefore, we have synthesized the series of disulfide LD, CD or PD-conjugate oligonucleotides. All these disulfide modifications improved the membrane permeability of Antisense DNA and siRNA. Furthermore, several disulfide-conjugated oligonucleotides showed higher cellular uptake over lipofection method without any cytotoxicity. Surprisingly, the disulfide modified oligonucleotides are internalized directly into the cytoplasm with only 10 min. This ultrafast internalization of oligonucleotides is an advantage for the therapeutic application. Currently, we are trying to apply this novel disulfide-based membrane permeable oligonucleotide (MPON) for the development of oligonucleotide-based therapeutics.</p>

    DOI: 10.5059/yukigoseikyokaishi.78.456

  3. ウイルスタンパク質の活性をトリガーとした新規不可逆阻害剤の開発

    福井竜介, 新美結士, 片倉秀雄, 鈴木哲郎, 村上努, 児玉栄一, 木村康明, 阿部洋

    日本薬学会年会要旨集(CD-ROM)   Vol. 139th ( 2 ) page: ROMBUNNO.23K‐pm11 - 103   2019.3

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    J-GLOBAL

  4. ウイルスポリメラーゼの不可逆阻害を目指した新規2'-&βセレノ核酸アナログの創製

    村上 努, 木村 康明, 新美 結士, 藤野 真之, 片倉 秀雄, 鈴木 哲朗, 児玉 栄一, 阿部 洋

    日本エイズ学会誌   Vol. 20 ( 4 ) page: 468 - 468   2018.11

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  5. Development of glutathione S-transferase (GST) covalent inhibitor

    Shishido Yuko, Tomoike Fumiaki, Kimura Yasuaki, Kuwata Keiko, Yano Takato, Fukui Kenji, Fujikawa Haruka, Sekido Yoshitaka, Murakami-Tonami Yuko, Kameda Tomoshi, Shuto Satoshi, Abe Hiroshi

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 255   page: .   2018.3

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  6. RETFプローブを用いた生体内の核酸検出

    友池史明, 山岡和樹, 伊藤真央, 木村康明, 井上貴文, 阿部洋

    日本化学会春季年会講演予稿集(CD-ROM)   Vol. 98th   2018

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  7. グルタチオン-S-トランスフェラーゼを標的とした共有結合性阻害剤の開発

    宍戸 裕子, 藤川 遥加, 友池 史明, 木村 康明, 桑田 啓子, 村上 優子, 福井 健二, 関戸 好孝, 矢野 貴人, 周東 智, 阿部 洋

    生命科学系学会合同年次大会   Vol. 2017年度   page: [3P - 0205]   2017.12

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    Language:Japanese   Publisher:生命科学系学会合同年次大会運営事務局  

  8. グルタチオンS-トランスフェラーゼのプローブ開発

    藤川 遥加, 宍戸 裕子, 村上 優子, 関戸 好孝, 阿部 洋

    日本癌学会総会記事   Vol. 76回   page: P - 2323   2017.9

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  9. 共有結合型グルタチオンS-転移酵素阻害剤の創薬研究

    宍戸 裕子, 関戸 好孝, 村上 優子, 阿部 洋

    日本癌学会総会記事   Vol. 76回   page: P - 1411   2017.9

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  10. 共有結合型グルタチオンS-転移酵素阻害剤の創薬研究

    宍戸 裕子, 藤川 遥加, 木村 康明, 友池 史明, 桑田 啓子, 矢野 貴人, 福井 健二, 関戸 好孝, 村上 優子, 周東 智, 阿部 洋

    日本薬学会年会要旨集   Vol. 137年会 ( 2 ) page: 68 - 68   2017.3

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  11. 糖部三員環型ヌクレオシドアナログの創成

    伏原大地, 福田隼, 阿部洋, 周東智

    日本薬学会年会要旨集(CD-ROM)   Vol. 137th   page: ROMBUNNO.26S‐pm10S   2017

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    J-GLOBAL

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Presentations 142

  1. 新規抗ウイルス薬を志向した修飾2-5Aの合成 Invited

    伏原 大地, 太田 杏摘, 田中 育, 今枝 昭裕, 永井 貴広, 星野 真一, 木村 康明, 友池 史明, 阿部 洋

    日本薬学会第138年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  2. カチオン性ポリマーを結合した核酸誘導体によるアンチセンス効果

    太田 杏摘, 伏原 大地, Zhaoma SHU, 阿部 奈保子, 木村 康明, 阿部 洋

    日本薬学会第138年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  3. 膜透過性核酸の開発

    Zhaoma SHU, 太田 杏積, 田中 育, 伏原 大地, 阿 部 奈保子, 友池 史明, 木村 康明, 阿部 洋

    日本薬学会第138年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  4. 真核生物翻訳系における終わりのない回転式翻訳現象

    清水 沙彩, 児玉 亜有実, 富田 貴志, 阿部 奈保子, 友池 史明, 木村 康明, 阿部 洋

    日本薬学会第138年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  5. 抗ウイルス活性を指向した新規2'修飾ヌクレオシドの合成および評価

    新美 結士, 片倉 秀雄, 阿部 奈保子, 木村 康明, 阿部 洋

    日本薬学会第138年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  6. 高分子核酸医薬の低分子化戦略:細胞内ビルドアップ法の開発

    木村 康明, 丸山 豪斗, 笈川 涼太, 吉永 静也, 辻 厳一郎, 阿部 奈保子, 松田 彰, 周東 智, 伊藤 嘉浩, 阿部 洋

    日本薬学会第138年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  7. 共有結合型GST阻害剤の開発

    富田貴志, 阿部奈保子, 木村康明, 鬼塚和光, 阿部洋

    日本化学会 第98春季年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  8. 抗ウイルス活性を指向したヌクレオシドの開発

    片倉秀雄, 新美結士, 木村康明, 鈴木哲郎, 村上優子, 阿部洋

    日本化学会 第98春季年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  9. N6-アルキルアデノシン導入によるRNAの機能制御

    今枝昭裕, 笈川涼太, 浅井潔, 桜庭俊, 岩切淳一, 阿部奈保子, 友池史明, 木村康明, 阿部洋

    日本化学会 第98春季年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  10. 膜透過性分子を結合したオリゴ核酸の合成

    田中育, 太田杏摘, 伏原大地, SHU Zhaoma, 阿部奈保子, 友池史明, 木村康明, 阿部洋

    日本化学会 第98春季年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  11. RETFプローブを用いた生体内の核酸検出

    友池史明, 山岡和樹, 伊藤真央, 木村康明, 井上貴文, 阿部洋

    日本化学会 第98春季年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  12. 蛍光オフ・オン型分子を導入した核酸プローブの開発

    山岡和樹, 伊藤真央, 阿部奈保子, 友池史明, 木村康明, 阿部洋

    日本化学会 第98春季年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  13. 多分岐型DNAケミカルライゲーションによる標的核酸分子のトポロジカル固定

    富田貴志, 阿部奈保子, 木村康明, 鬼塚和光, 阿部洋

    日本化学会 第98春季年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  14. グルタチオン-S-トランスフェラーゼを標的とした共有結合性阻害剤の開発

    宍戸裕子、藤川遥加、友池史明、木村康明、桑田啓子、村上優子、福井健二、関戸好孝、矢野貴人、周東智、阿部洋

    分子生物学会 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  15. RNA Interference by Intracellar Buildup of siRNA International conference

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    Event date: 2017.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  16. Development of intracellular RNA detection probe enable chemical signal amplification International conference

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    Event date: 2017.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  17. Development of Anti-cancer Agents based on Synthetic Lethality by LATS Mutation.

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    Event date: 2017.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  18. 抗ウイルス活性を指向した2'-β-チオ核酸の開発

    片倉秀雄, 木村康明, 阿部洋

    統合物質創製化学研究推進機構 第3回 国内シンポジウム 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  19. ロタキサン構造形成による新規アンチセンス法の開発

    富田貴志, 阿部奈保子, 木村康明, 阿部洋

    統合物質創製化学研究推進機構 第3回 国内シンポジウム 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  20. 細胞内グルタチオン-S-トンランスフェラーゼ活性を検出するためのプローブ開発

    友池史明、宍戸裕子、藤川遥加、木村康明、柴田綾、周東智、阿部洋

    日本分析化学会第66年会 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  21. 高分子核酸医薬の低分子戦略:細胞内ビルドアップ法の開発

    木村康明、丸山豪斗、伊藤美香、笈川涼太、早川真由、辻厳一郎、阿部奈保子、松田彰、周東智、伊藤嘉浩、阿部洋

    第11回バイオ関連化学シンポジウム 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  22. 高分子核酸医薬の低分子戦略:細胞内ビルドアップ法の開発

    木村康明、丸山豪斗、笈川涼太、早川真由、吉永静也、辻厳一郎、阿部奈保子、松田彰、周東智、伊藤嘉浩、阿部洋

    日本核酸医薬学会第3回年会 

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    Event date: 2017.7

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  23. 高分子核酸医薬の低分子戦略:細胞内ビルドアップ法の開発

    木村康明、丸山豪斗、伊藤美香、笈川涼太、早川真由、辻厳一郎、阿部奈保子、松田彰、周東智、伊藤嘉浩、阿部洋

    ケミカルバイオロジー学会 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  24. 高効率な核酸検出を可能にする核酸鋳型反応の開発

    伊藤真央、柴田綾、阿部奈保子、木村康明、阿部洋

    日本薬学会第137年会 

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    Event date: 2017.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  25. 共有結合型グルタチオンS-転移酵素阻害剤の創薬研究

    宍戸裕子、藤川遙加、木村康明、友池史明、桑田啓子、矢野貴人、福井健二、関戸好孝、村上優子、周東智、阿部洋

    日本薬学会137年会 

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    Event date: 2017.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  26. 糖部三員環型ヌクレオシドアナログの創成

    伏原大地、福田隼、阿部洋、周東智

    日本薬学会第137年会 

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    Event date: 2017.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  27. ビルドアップ型核酸分子の開発

    吉永静也、辻厳一郎、阿部奈保子、友池史明、木村康明、阿部洋

    統合物質創製化学研究推進機構第2回国内シンポジウム 

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    Event date: 2017.1

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  28. 光解除性保護基を有するヌクレオチドを利用した長鎖RNAのケミカルライゲーション

    辻厳一郎、笈川涼太、早川真由、木村康明、阿部洋

    統合物質創製化学研究推進機構第2回国内シンポジウム 

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    Event date: 2017.1

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  29. 共有結合型グルタチオンS-転移酵素阻害剤の創薬研究

    宍戸裕子、藤川遙加、木村康明、友池史明、桑田啓子、矢野貴人、福井健二、関戸好孝、村上優子、周東智、阿部洋

    第34回メディシナルケミストリーシンポジウム 

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    Event date: 2016.11 - 2016.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  30. 合成環状RNAからのタンパク質発現

    児玉亜有実、阿部奈保子、友池史明、伊藤嘉浩、松本健、吉田稔、清水義宏、亀田倫史、阿部洋

    第39回分子生物学会 

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    Event date: 2016.11 - 2016.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  31. 細胞内ビルドアップ型SiRNAを志向した新規核酸連結反応

    早川真由、笈川涼太、丸山豪斗、阿部奈保子、木村康明、周東智、松田彰、阿部洋

    日本核酸医薬学会第二会年会 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  32. Development of novel chemical ligation reaction for RNA strands International conference

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    Event date: 2016.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  33. 求電子的ホスホロチオエステルによる核酸の化学的連結反応

    木村康明、丸山豪斗、笈川涼太、早川真由、阿部奈保子、松田彰、周東智、伊藤嘉浩、阿部洋

    第10回バイオ関連化学シンポジウム 

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    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  34. Nile Blueを基本骨格とした脂肪滴検出プローブの創製

    戸田直宏、伊藤美香、石田綾乃、鬼頭宏任、横川大輔、阿部洋

    第10回バイオ関連化学シンポジウム 

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    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  35. Rolling circle translation of Circular RNA

    Naoko Abe, Yasuaki Kimura, Fumiaki Tomoike, Ken Matsumoto, Minoru Yoshida, Yoshihiro Ito, Hiroshi Abe

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    Event date: 2016.6 - 2016.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  36. 核酸のケミカルバイオロジー

    阿部 洋

    総合物質創製化学研究推進機構キックオフシンポジウム 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  37. Rolling circle translation using small circular RNA International conference

    Pacifichem 2015 

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    Event date: 2015.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  38. 合成環状RNAからのタンパク質発現

    阿部洋、阿部奈保子、伊藤嘉浩、松本健、吉田稔

    日本核酸医薬学会第1回年会 

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    Event date: 2015.11 - 2015.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  39. 細胞内RNAの解析と機能制御

    阿部洋

    特別招待セミナー(愛知がんセンター) 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  40. DNA templated reaction for efficient signal amplification and its steady-state kinetic analysis of the turnover cycle International conference

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    Event date: 2015.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  41. Synthetic biology of Circular Oligonucleotide International conference

    Hiroshi Abe

    The 3rd International Symposium on Transformative Bio-Molecules, Nagoya Univaersity 

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    Event date: 2015.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  42. 人工核酸を用いた細胞内RNAの解析及び機能制御

    阿部洋

    第1回新しい原子分子組織化物質・材料創出に向けた光・量子ビーム応用技術ン調査専門委員会 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  43. 標的を触媒として利用する遺伝子検出のための化学反応プロ−ブの開発

    阿部洋

    若手研究者のための有機化学札幌セミナー 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  44. DNA templated reaction for efficient signal amplication and its steady-state kinetic analysis of the turmover cycle

    The 41st International Symposium on Nucleic Acids Chemistry 

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    Event date: 2014.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  45. 細胞内RNAの機能制御と解析

    阿部洋

    名古屋大学、野依記念物質科学研究館講演室 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  46. ROLLING CIRCLE AMPLIFICATION OF PEPTIDE IN TRANSLATION SYSTEM USING SMALL CIRCULAR RNA

    51st Japanese Peptide Symposium, Tokushima  

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    Event date: 2014.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  47. Synthetic bioligy of Circular RNA

    RIKEN SYMPOSIUM & 15th Tokyo RNA club 

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    Event date: 2014.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  48. DNA templated chemical reaction for detection of nucleic acids International conference

    Hiroshi Abe

    China/Japan Young Chemists Forum (Molecular Imgaing for Chemical Biology), 29th Chinese Chemical Society congress 

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    Event date: 2014.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  49. RNAのナノ構造化に基づく機能創発

    阿部洋

    RNAインフォマティクス道場 in 札幌 

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    Event date: 2014.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  50. 環状RNAの機能探索

    「阿部洋」「阿部奈保子」「中野佑妃子、伊藤嘉浩」「周東智」

    第51回日本生化学会北海道支部例会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  51. RNAナノ構造化による医薬機能創発

    阿部洋

    第25回未来創薬・医療イノベーションセミナー 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  52. ナノ構造化による医薬機能創発

    阿部洋

    東京リサーチパークセミナー 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  53. Synthetic Biology of Circular RNA

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    Event date: 2014.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  54. 環状RNAによる終わりのない回転式タンパク質翻訳

    「阿部洋」「阿部奈保子」「丸山豪斗」「中野佑妃子」「周東智」「松田彰」「伊藤嘉浩」

    第23回アンチセンスシンポジウム 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  55. RNAを植物から考えるー植物を支えるRNA機能ー「化学反応プロープを用いたRNAイメージング法の開発」

    阿部洋

    第3回植物RNA研究ネットワークシンポジウム 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  56. Rolling Circle Amplification in Translation System using small Circular RNA

    Hiroshi Abe, Naoko Abe, Michio Hiroshima, Hideto Maruyama, Yuko Nakashima, Yukiko Nakno,Akira Matsuda, SAtoshi Shuto, Yasushi Sako, Yoshihiro Ito

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    Event date: 2013.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  57. ナノ構造化したRNA分子の機能創発

    阿部洋

    日本農芸化学会中部支部第169回例会「核酸科学の新潮流」 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  58. Nano-structured RNA for RNA interference International conference

    Hiroshi Abe

    ISAJ(Inadian Scientist, Association in Japan) symposium 

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    Event date: 2013.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  59. ナノ構造化RNAの機能創発

    阿部洋

    スパイバー社、鶴岡 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  60. まるい核酸の研究

    阿部洋

    北海道大学大学院講義 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  61. Synthetic biology of Nano-structured Nucleic Acids

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  62. 細胞内遺伝子発現の解析と制御法開発

    阿部洋

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  63. バイオイメージングに基づく診断法の開発

    阿部洋

    JST推薦シーズ新技術説明会 第2回ライフイノベーションの分野(創薬、医療技術) 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  64. RNAイメージング法の開発(代表者 常田聡)

    阿部洋

    大学院講義 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  65. 有機溶媒に溶けるDNAの構造と触媒機能

    「阿部洋」「阿部奈保子」「柴田綾」「伊藤圭司」「伊藤美香」「實吉尚郎」「田中好幸」「周東智」「伊藤嘉浩」

    第6回バイオ関連化学合同シンポジウム 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  66. 「核酸高分子のナノ構造化や鋳型反応による機能創出」

    阿部洋

    第58回高分子研究発表会(代表者 西野孝) 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  67. ナノ構造を制御したRNAを用いたRNA干渉法

    「阿部洋」【阿部奈保子」「西原みづき」「永井千里」「畠山浩人」「原島秀吉」「大城敬人」「前田瑞夫」「中嶋裕子」「伊藤嘉浩」

    日本DDS学会第28回学術集会 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  68. 遺伝子シグナルの化学増幅

    阿部洋

    北海道大学薬学部講演会(代表者 周東智) 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  69. 化学反応プローブを用いた細胞内遺伝子診断法の開発

    阿部洋

    Pharmaco-Hematology シンポジウム「血液からの創薬を考える」(代表者 宮崎洋)シンポジウム2「”眼に見える”分子機能研究へ向けた新展開」 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  70. ナノ構造化RNAを用いるRNA干渉法

    阿部洋

    日本薬学会シンポジウム「ナノサイズの分子設計:診断・創薬へのアプローチ」(代表者 阿部洋) 

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    Event date: 2012.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  71. 生細胞内遺伝子の解析と制御を目的とした機能性核酸分子の創製

    阿部洋

    次代を担う若手大学人育成イニシアティブセミナー 

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    Event date: 2012.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  72. 遺伝子シグナルの化学的増幅

    阿部洋

    トクシマ・ファルマ・トライアングル(TPT)構築事業 特別講演会 

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    Event date: 2011.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  73. 「核酸工学・核酸医薬の新展開」「ナノ構造化RNAを用いるRNA干渉会」

    阿部洋

    第17回創剤フォーラム若手研究会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  74. Artificial Nucleic Acid probe for analysis and regulation of RNA expression in living cells International conference

    Hiroshi Abe

    Division of Biochemical Toxicology, Karolinska Institut 

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    Event date: 2011.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  75. Detection and Control of gene expression using artificial nucleic acids International conference

    Hiroshi Abe

    Division of Biochemical Toxicology, Karolinska Institut 

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    Event date: 2011.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  76. 医療応用を目指した人工核酸分子の創製

    阿部洋

    高分子学会関東支部 第22回埼玉地区談話会 

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  77. 人工核酸分子を用いた遺伝子発現の解析と制御

    阿部洋

    大阪大学 免疫学フロンティア研究センターセミナー 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  78. 細胞内遺伝子発現の解析と制御を目的とした機能性核酸分子の創製

    阿部洋

    薬学会奨励賞受賞講演 

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    Event date: 2010.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  79. 細胞内現象を解析・制御する分子の創製

    阿部洋

    群馬大学 光化学研究会合同研究発表会 

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    Event date: 2009.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  80. Chemical reaction triggered fluorogenic probe for RNA detection in living cells International conference

    Hiroshi Abe

    BIT's 3rd world congress of Gene-2009 

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    Event date: 2009.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  81. Nanocircular RNA for RNA interference International conference

    Hiroshi Abe

    The 6th International symposium on Nucleic Acid Chemistry (6ISNAC2009) 

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    Event date: 2009.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  82. ダンベル型ナノサークルRNAを用いるRNA干渉法

    「阿部洋」「阿部奈保子」「原田充」「常田聡」「伊藤嘉浩」

    日本薬学会第129年会 

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    Event date: 2009.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  83. 細胞内RNA検出プローブの開発

    「阿部洋」「古川和寛」「王瑾」「鳥田美和子」「常田聡」「伊藤嘉浩」

    第18回アンチセンスシンポジウム 

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    Event date: 2008.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  84. 新規蛍光化合物を導入したプロ−ブによる遺伝子シグナルの化学増幅

    「阿部洋」「古川和寛」「王瑾」「鳥田美和子」「常田聡」「伊藤嘉浩」

    第34回反応と合成の進歩シンポジウム 

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    Event date: 2008.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  85. ダンベル型ナノサークルRNAを用いるRNA干渉法

    「阿部洋」「阿部奈保子」「原田充」「常田聡」「伊藤嘉浩」

    第27回メディシナルケミストリーシンポジウム 

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    Event date: 2008.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  86. 機能性人工核酸の創製

    阿部洋

    東京大学薬学部 

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    Event date: 2008.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  87. RNAのシンセティックバイオロジー

    阿部洋

    東京薬科大学 

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    Event date: 2008.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  88. 人工核酸を用いる細胞内遺伝子発現の解析と制御

    阿部洋

    日本化学会関東支部 シンポジウム 

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    Event date: 2008.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  89. 新規蛍光化合物を導入した化学反応プローブによる遺伝子シグナルの増幅

    「阿部洋」「古川和寛」「王瑾」「鳥田美和子」「常田聡」「伊藤嘉浩」

    第3回バイオ関連化学合同シンポジウム 

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    Event date: 2008.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  90. Nanocircular RNAs for RNA interference International conference

    Hiroshi Abe, Naoko Abe, Mitsuru harada, Satoshi Tsuneda, Yoshihiro Ito

    Joint Stmposium of the 18th International Round table on Nucleoside, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry  

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    Event date: 2008.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  91. 機能性人工核酸の創製

    阿部洋

    分子研究会ー物質系と生体系での自己組織化ー 

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    Event date: 2008.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  92. 人工核酸を用いる細胞内遺伝子発現の解析と制御

    阿部洋

    第6回ライフサーベイヤシンポジウム 

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    Event date: 2008.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  93. ダンベル型なのサークルRNAを用いるRNA干渉法

    「阿部洋」「阿部奈保子」「原田充」「常田聡」「伊藤嘉浩」

    第24回DDS学会 

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    Event date: 2008.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  94. ダンベル型ナノサークルRNAを用いるRNA干渉法

    「阿部洋」「阿部奈保子」「原田充」「常田聡」「伊藤嘉浩」

    第3回ケミカルバイオロジー研究会年会 

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    Event date: 2008.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  95. 化学反応プローブを用いた細胞内遺伝子検出

    阿部洋

    第59回日本生物工学会大会 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  96. 新規蛍光化合物の合成と遺伝子検出への応用

    「阿部洋」「王瑾」「古川和寛」「島田美和子」「戸田雅也」「常田聡」「伊藤嘉浩」

    第22回生体機能関連化学シンポジウム 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  97. 有機溶液に溶ける核酸の構造解析:有機溶媒中のGカルテット構造

    「阿部洋」「阿部奈保子」「伊藤嘉浩」

    第56回高分子討論会 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  98. 核酸の有機溶媒可視化と構造解析

    「阿部洋」「阿部奈保子」「神明博」「伊藤嘉浩」

    第56回高分子学会年次大会 

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    Event date: 2007.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  99. 化学的DNA連結反応を用いるヒト生細胞内RNAの可視化と定量

    阿部洋

    第22回ケミカルバイオロジー研究会 

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    Event date: 2006.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  100. Structure analysis of oligonucleotide in organic solvent International conference

    Hiroshi Abe, Naoko Abe, Yoshihiro Ito

    33rd Symposium on Nucleic Acids Chemistry 

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    Event date: 2006.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  101. 化学的DNA連結反応を持ちいるヒト生細胞内mRNAの検出

    「阿部洋」「Kool Eric T」

    第16回アンチセンスシンポジウム 

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    Event date: 2006.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  102. 有機溶媒中の核酸の構造

    「阿部洋」『阿部奈保子」「神明博」「伊藤嘉浩」

    第21回生体機能関連化学シンポジウム(バイオテクノロジー部会9回)・生命化学研究会(9回)合同シンポジウム 

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    Event date: 2006.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  103. 細胞内分子遺伝子診断

    阿部洋

    第1回バイオ医工学シンポジウムーマイクロアレイ・バイオチップ最前線ー 

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    Event date: 2006.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  104. 化学的DNA連結反応を用いる細胞内遺伝子診断

    「阿部洋」「Kool Eric T」

    日本薬学会126年会 

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    Event date: 2006.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  105. 抗ウイルス活性を指向した新規2'修飾ヌクレオシドの合成および評価

    新美 結士, 片倉 秀雄, 阿部 奈保子, 木村 康明, 阿部 洋

    日本薬学会第138年会  2018.3 

  106. 抗ウイルス活性を指向したヌクレオシドの開発

    片倉秀雄, 新美結士, 木村康明, 鈴木哲郎, 村上優子, 阿部洋

    日本化学会 第98春季年会  2018.3 

  107. 抗ウイルス活性を指向した2'-β-チオ核酸の開発

    片倉秀雄, 木村康明, 阿部洋

    統合物質創製化学研究推進機構 第3回 国内シンポジウム  2017.10 

  108. 多分岐型DNAケミカルライゲーションによる標的核酸分子のトポロジカル固定

    富田貴志, 阿部奈保子, 木村康明, 鬼塚和光, 阿部洋

    日本化学会 第98春季年会  2018.3 

  109. 化学的シグナル増幅を可能とするプローブによる細胞内RNA検出法

    伊藤真央, 柴田綾, 阿部奈保子, 友池史明, 木村康明, 阿部洋

    日本RNA学会  2017.7 

  110. 共有結合性GST阻害剤の開発

    藤川遥加, 宍戸裕子, 木村康明, 友池史明, 村上優子, 青木正博, 福井健二, 矢野貴人, 阿部洋

    第48回中化連秋季大会  2017.11 

  111. 共有結合型グルタチオンS-転移酵素阻害剤の開発

    宍戸裕子, 藤川遥加, 木村康明, 友池史明, 桑田啓子, 福井健二, 村上優子, 亀田倫史, 周東智, 阿部洋

    第11回バイオ関連化学シンポジウム  2017.9 

  112. 共有結合型グルタチオンS-転移酵素阻害剤の創薬研究

    宍戸裕子, 関戸好孝, 村上優子, 阿部洋

    日本癌学会  2017.9 

  113. 共有結合型GST阻害剤の開発

    藤川遥加, 宍戸裕子, 木村康明, 友池史明, 村上優子, 青木正博, 阿部洋

    日本化学会 第98春季年会  2018.3 

  114. ロタキサン構造形成による新規アンチセンス法の開発

    富田貴志, 阿部奈保子, 木村康明, 阿部洋

    統合物質創製化学研究推進機構 第3回 国内シンポジウム  2017.10 

  115. グルタチオン-S-トランスフェラーゼを標的とした共有結合性阻害剤の開発

    宍戸裕子, 藤川遥加, 友池史明, 木村康明, 桑田啓子, 村上優子, 福井健二, 関戸好孝, 矢野貴人, 周東智, 阿部洋

    ConBio2017  2017.12 

  116. グルタチオン-S-トランスフェラーゼのプローブ開発

    宍戸裕子, 村上優子, 関戸好孝, 阿部洋

    日本癌学会  2017.9 

  117. カチオン性ポリマーを結合した核酸誘導体によるアンチセンス効果

    太田 杏摘, 伏原 大地, Zhaoma SHU, 阿部 奈保子, 木村 康明, 阿部 洋

    日本薬学会第138年会  2018.3 

  118. Si-Si結合の特性を利用した光分解性保護基の開発

    伊藤 真央, 金田 龍太郎, 木村 康明, 周東 智, 阿部 洋

  119. RNA干渉のためのナノ構造デザイン

    Shu Zhaoma, 阿部奈保子, 友池史明, 木村康明, 伊藤嘉浩, 阿部洋

    日本核酸医薬学会第3回年会  2017.7 

  120. RNA Interference by Intracellar Buildup of siRNA

    木村康明, 丸山豪斗, 笈川涼太, 辻厳一郎, 吉永静也, 阿部奈保子, 周東智, 松田彰, 伊藤嘉浩, 阿部洋

    日本核酸化学会年会  2017.11 

  121. RETFプローブを用いた生体内の核酸検出

    友池史明, 山岡和樹, 伊藤真央, 木村康明, 井上貴文, 阿部洋

    日本化学会 第98春季年会  2018.3 

  122. N6-アルキルアデノシン導入によるRNAの機能制御

    今枝昭裕, 笈川涼太, 浅井潔, 桜庭俊, 岩切淳一, 阿部奈保子, 友池史明, 木村康明, 阿部洋

    日本化学会 第98春季年会  2018.3 

  123. Development of intracellular RNA detection probe enable chemical signal amplification

    阿部洋, 伊藤真央, 友池史明, 木村康明, 阿部奈保子

    日本核酸化学会年会  2017.11 

  124. Development of Anti-cancer Agents based on Synthetic Lethality by LATS Mutation.

    Nguyen Hong Nhung, 木村康明, 村上優子, 阿部洋

    統合物質創製化学研究推進機構 第3回 国内シンポジウム  2017.10 

  125. 擬ロタキサン構造形成による翻訳制御

    富田貴志, 阿部奈保子, 木村康明, 阿部洋

    第48回中化連秋季大会  2017.11 

  126. 高分子核酸医薬の低分子戦略:細胞内ビルドアップ法の開発

    木村康明, 丸山豪斗, 伊藤美香, 笈川涼太, 早川真由, 辻厳一郎, 阿部奈保子, 松田彰, 周東智, 伊藤嘉浩, 阿部洋

    第11回バイオ関連化学シンポジウム  2017.9 

  127. 高分子核酸医薬の低分子化戦略:細胞内ビルドアップ法の開発

    木村 康明, 丸山 豪斗, 笈川 涼太, 吉永 静也, 辻 厳一郎, 阿部 奈保子, 松田 彰, 周東 智, 伊藤 嘉浩, 阿部 洋

    日本薬学会第138年会  2018.3 

  128. 遺伝子発現制御のためのRNA分子の形状デザイン

    阿部洋, 阿部奈保子, 木村康明, 友池史明

    ConBio2017  2017.12 

  129. 蛍光オフ・オン型分子を導入した核酸プローブの開発

    山岡和樹, 伊藤真央, 阿部奈保子, 友池史明, 木村康明, 阿部洋

    日本化学会 第98春季年会  2018.3 

  130. 膜透過性核酸の開発

    Zhaoma SHU, 太田 杏積, 田中 育, 伏原 大地, 阿 部 奈保子, 友池 史明, 木村 康明, 阿部 洋

    日本薬学会第138年会  2018.3 

  131. 膜透過性分子を結合したオリゴ核酸の合成

    田中育, 太田杏摘, 伏原大地, SHU Zhaoma, 阿部奈保子, 友池史明, 木村康明, 阿部洋

    日本化学会 第98春季年会  2018.3 

  132. 細胞内グルタチオン-S-トンランスフェラーゼ活性を検出するためのプローブ開発

    友池史明, 宍戸裕子, 藤川遥加, 木村康明, 柴田綾, 周東智, 阿部洋

    日本分析化学会第66年会  2017.9 

  133. 真核生物翻訳系における終わりのない回転式翻訳現象

    清水 沙彩, 児玉 亜有実, 富田 貴志, 阿部 奈保子, 友池 史明, 木村 康明, 阿部 洋

    日本薬学会第138年会  2018.3 

  134. 環状RNAを用いた終わりのない回転式翻訳によるタンパク質合成の効率化

    児玉亜有実, 阿部奈保子, 友池史明, 伊藤嘉浩, 松本健, 吉田稔, 清水義宏, 亀田倫史, 阿部洋

    ConBio2017  2017.12 

  135. 環状RNAを用いた回転式翻訳によるタンパク質合成効率化

    児玉亜有実, 阿部奈保子, 友池史明, 木村康明, 伊藤嘉浩, 松本健, 吉田稔, 清水義宏, 亀田倫史, 阿部洋

    日本RNA学会  2017.7 

  136. 環境応答性環状オリゴ核酸による遺伝子発現制御

    吉永静也, 阿部奈保子, 木村康明, 友池史明, 阿部洋

    第48回中化連秋季大会  2017.11 

  137. 求電子的リン酸基を用いた核酸ケミカルライゲーション反応

    笈川涼太, 早川真由, 丸山豪斗, 阿部奈保子, 友池史明, 木村康明, 周東智, 松田彰, 南川典昭, 阿部洋

    第48回中化連秋季大会  2017.11 

  138. 機能性核酸合成を志向した化学的核酸連結反応

    笈川涼太, 早川真由, 丸山豪斗, 阿部奈保子, 木村康明, 周東智, 松田彰, 南川典昭, 阿部洋

    日本核酸医薬学会第3回年会  2017.7 

  139. 核酸医薬のための化学的アプローチ 硫黄のマジック Invited

    阿部 洋

    日本薬学会  2021.3.27 

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    Presentation type:Oral presentation (invited, special)  

  140. 有機化学を基盤とする核酸医薬へのアプローチ

    阿部 洋

    有機合成化学協会「ニューモダリティと有機合成化学」第5回勉強会  2021.8.19 

  141. 新規抗ウイルス薬を志向した修飾2-5Aの合成

    伏原 大地, 太田 杏摘, 田中 育, 今枝 昭裕, 永井 貴広, 星野 真一, 木村 康明, 友池 史明, 阿部 洋

    日本薬学会第138年会  2018.3 

  142. RNA創薬を目的とした核酸分子の開発

    阿部 洋

    千里ライフサイエンス振興団  2021.10.20 

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Works 10

  1. Protein detection using oligonucleotide probes

    2009

  2. Synthetic nanocircular RNA for controlling of gene expression

    2009

  3. In vitro selection of RNA aptamer to hemin

    2008

  4. Fluorogenic trobe triggered by reduction for nucleic acids sensing

    2008

  5. Nanocircular RNAs fopr RNA interference

    2008

  6. Multiple chemical ligation under thermal cycle

    2007

  7. Intermolecular transfer of aminoacylated adenosine towards chemical aminoacylation of tRNA

    2007

  8. Structure analysis of oligonucleotide in organic solvent

    2006

  9. Universal linkers for signal amplification in auto-ligating probes

    2005

  10. Synthesis and biological activity of adenophostin derivativesas IP3 receptor ligands

    2002

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Research Project for Joint Research, Competitive Funding, etc. 11

  1. ポスト切断PCRプライマーを用いた新規DNAアセンブリ法の開発

    2018.10 - 2019.3

  2. 化学を基盤とするゲノムスケールDNA合成技術の開発

    2018 - 2025

  3. 長鎖DNAの細胞内ビルドアップ法の開発

    2018 - 2019

  4. 合成致死表現型を指標とした新規悪性中皮腫革新的がん医療実用化研究事業

    2017.11 - 2018.3

  5. 人工mRNA・非コードRNA分解機構の解明とRNA医薬安定化技術の開発

    2017.4 - 2020.3

    国内共同研究 

  6. 新規精神・発達障害治療薬の探索

    2017.4 - 2020.3

  7. RNAケミカルライゲーション法による翻訳可能な長鎖mRNAの全合成

    2016.1 - 2019.7

    国内共同研究 

  8. 環状RNAを用いたタンパク質翻訳現象の理解と利用

    2015.4

    国内共同研究 

  9. 蛋白質の高効率生産法の開発

    2015.4 - 2018.3

    国内共同研究 

  10. 脳神経回路の形成・動作と制御「シナプス可塑性に関わるRNA群の革新的イメージング法の開発

    2011

    科学技術振興機構 

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    Grant type:Competitive

  11. 単一分子レベルの酵素反応解析から癌治療法開発までの複合領域研究

    2011

    科学技術振興機構 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 19

  1. 修飾塩基を持つRNAの情報解析基盤技術の開発

    Grant number:21H04912  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(A)

    浅井 潔, 阿部 洋, 櫻庭 俊

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    Authorship:Coinvestigator(s) 

    既に開発した様々なRNA2次構造情報解析ソフトウェアを基盤として、修飾塩基のエネルギーパラメー
    タを組み込むことで、修飾塩基を含むRNAの2次構造情報解析を実現するソフトウェアを開
    発する。さらに、機械学習を取り入れたエネルギーパラメータ推定法を開発する。また、RNA配列中の修
    飾の種類・位置を同定するため、1分子シークエンサの測定信号から修飾塩基を含む塩基配
    列を同定する手法を開発する。これらの技術の有用性を実証するため、塩基修飾がmRNAの
    翻訳効率に及ぼす影響を予測する手法の開発を行う。

  2. 高分子RNA医薬の中分子化戦略

    2018.4 - 2020.3

    科学研究費補助金  新学術領域研究

  3. Medium molecularization strategy of high molecular weight RNA medicine

    Grant number:18H04398  2018.4 - 2020.3

    Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

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    Authorship:Principal investigator 

    Grant amount:\5200000 ( Direct Cost: \4000000 、 Indirect Cost:\1200000 )

  4. 高分子RNA医薬の中分子化戦略

    2018.4 - 2020.3

    阿部 洋

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    Authorship:Principal investigator  Grant type:Competitive

  5. 核酸鋳型化学反応の遷移状態制御に基づく触媒回転数の向上

    2016.7 - 2019.3

    科学研究費補助金  基盤研究(B)

  6. Improvement of catalytic turnover based on transition state control of oligonucleotide template chemical reaction

    Grant number:16KT0052  2016.7 - 2019.3

    Abe Hiroshi

      More details

    Authorship:Principal investigator 

    Grant amount:\18590000 ( Direct Cost: \14300000 、 Indirect Cost:\4290000 )

    The fluorescence reaction based on the oligonucleotide (ON) template reaction is one of the most basic working principles of the RNA detection probe. In this method, an ON probe having a reactive functional group and an ON probe having a fluorescent precursor whose fluorescence is suppressed by a protecting group are associated on the target RNA, and then the protective group is removed and fluorescence signal is generated. Since this fluorescence reaction specifically occurs in the presence of target RNA, it can be the working principle RNA detection probe. In order to detect intracellular RNA highly sensitively, we worked on (1) accelerating ON template reaction and (2) development of a new method of intracellular administration of ON probe without lipofection. Prospective results were obtained in (1) by appropriately selecting the nucleophile for the reaction, and in (2) by use of phosphorothioate in the ON probe.

  7. 核酸鋳型化学反応の遷移状態制御に基づく触媒回転数の向上

    2016.7 - 2019.3

    阿部 洋

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    Authorship:Principal investigator  Grant type:Competitive

  8. エピトランスクリプトーム解析のためのRNAインフォマティクス基盤技術

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(A)

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    Authorship:Principal investigator 

  9. 環状RNAを用いたタンパク質合成法

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  10. RNA informatics for epi-transcriptome analysis

    Grant number:16H02484  2016.4 - 2019.3

    Asai Kiyoshi

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    Authorship:Coinvestigator(s) 

    The energy parameters of the important modified bases, inosine and N6 methyladenosine were identified by a combination of thermometric experiments and molecular simulations. The effect of estimation error on structure prediction was evaluated and presented by theoretical analysis and computer experiments. A model of the effect of A-to-I editing on translational repression efficiency by miRNA was constructed and presented in a joint study using the identified inosine parameters.
    We have improved RintD, an analysis tool for secondary structure probability distribution, by developing RintW, which calculates the distribution of base pair probability, and RintC, which speeds up the calculation with maximum base pair constraint. At that time, the effect of the Fourier transform on the numerical error was analyzed using the accuracy guarantee calculation, and it was shown that the large probability was reliable.

  11. Protein synthesis using circular RNA

    Grant number:16H04178  2016.4 - 2019.3

    Abe Hiroshi

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    Authorship:Principal investigator 

    Grant amount:\17810000 ( Direct Cost: \13700000 、 Indirect Cost:\4110000 )

    Protein having a repetitive sequence is generated in a translation reaction on circular RNA template which contains a continuous open reading frame, because the ribosome performs translation rotating many times on the RNA. Optimization of the reaction condition in a E. coli cell-free translation system was performed. Development of efficient functional protein expression method in mammalian translation systems were carried out.

  12. エピトランスクリプトーム解析のためのRNAインフォマティクス基盤技術

    2016.4 - 2019.3

    浅井潔

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    Grant type:Competitive

  13. 環状RNAを用いたタンパク質合成法

    2016.4 - 2019.3

    阿部 洋

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    Authorship:Principal investigator  Grant type:Competitive

  14. iRed/iPedの完全化学合成を基軸とした実践的がん創薬基盤研究

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

  15. Investigation of practical anticancer strategy based on chemically synthesized iRed/iPed

    Grant number:15H04656  2015.4 - 2018.3

    MINAKAWA Noriaki

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    Authorship:Coinvestigator(s) 

    In this study, research was conducted to further enhance the function of a DNA device (iRed) capable of expressing functional RNA in cells. As a result, (1) cyclization aimed at stabilizing iRed, (2) complete chemical synthesis of iRed, (3) searching for new cancer therapeutic drugs by combination with innovative delivery method, and (4) possibility to evolve this device to iPed expressing functional peptide peptide/protein were demonstrated.

  16. GSTを標的とする分子プローブの開発

    2015.4 - 2017.3

    阿部 洋

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    Authorship:Principal investigator  Grant type:Competitive

  17. GSTを標的とする分子プローブの開発

    2015 - 2017.3

    科学研究費補助金  挑戦的萌芽研究

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    Authorship:Principal investigator 

  18. ナノ構造化と鋳型反応に基づくRNAの医薬機能創発

    2013

    科学研究費補助金  基盤研究(B)

  19. ナノ構造化と鋳型反応に基づくRNAの医薬機能創発

    2013

    阿部 洋

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    Authorship:Principal investigator  Grant type:Competitive

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Media Coverage 3

  1. mRNAワクチン国産化目指す 名古屋大など Newspaper, magazine

    中日新聞  朝刊  2022.3

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    Author:Other 

  2. mRNAワクチン国産化へ 大学発ベンチャー設立 Newspaper, magazine

    産経新聞  2022.3

  3. スタートアップのCrafton Biotechnology、日本発の技術でmRNA医薬を開発へ Internet

    日経バイオテク  2020.3

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    Author:Other 

Academic Activities 1

  1. 日本核酸医薬学会

    Role(s):Planning, management, etc.

    幹事  2021.2

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    Type:Academic society, research group, etc.