Organization
Nagoya University Hospital Center for Postgraduate Clinical Training and Career Development Lecturer of hospital
Title
Lecturer of hospital
MURAMATSU Yukako
Degree 1
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医学博士 （ 2016.4 名古屋大学 ）
Research Areas 2
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Life Science / Embryonic medicine and pediatrics
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Life Science / Genetics
Papers 24
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Nishikawa, M; Hayashi, S; Nakayama, A; Nishio, Y; Shiraki, A; Ito, H; Maruyama, K; Muramatsu, Y; Ogi, T; Mizuno, S; Nagata, K
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE Vol. 1871 ( 1 ) page： 167520 2025.1
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Sato, Y; Shimizu, S; Ueda, K; Suzuki, T; Suzuki, S; Miura, R; Ando, M; Tsuda, K; Iwata, O; Muramatsu, Y; Kidokoro, H; Hirakawa, A; Hayakawa, M
STEM CELLS TRANSLATIONAL MEDICINE Vol. 13 ( 11 ) page： 1053 - 1066 2024.10
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Comprehensive molecular and clinical findings in 29 patients with multi-locus imprinting disturbance
Urakawa, T; Soejima, H; Yamoto, K; Hara-Isono, K; Nakamura, A; Kawashima, S; Narusawa, H; Kosaki, R; Nishimura, Y; Yamazawa, K; Hattori, T; Muramatsu, Y; Inoue, T; Matsubara, K; Fukami, M; Saitoh, S; Ogata, T; Kagami, M
CLINICAL EPIGENETICS Vol. 16 ( 1 ) page： 138 2024.10
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Suzuki, H; Muramatsu, Y; Miya, F; Asada, H; Yamada, M; Nishimura, G; Kosaki, K; Takenouchi, T
EUROPEAN JOURNAL OF MEDICAL GENETICS Vol. 70 page： 104955 2024.8
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Sugimoto, T; Inagaki, H; Mariya, T; Kawamura, R; Taniguchi-Ikeda, M; Mizuno, S; Muramatsu, Y; Tsuge, I; Ohashi, H; Saito, N; Hasegawa, Y; Ochi, N; Yamaguchi, M; Murotsuki, J; Kurahashi, H
HUMAN GENETICS Vol. 142 ( 10 ) page： 1451 - 1460 2023.10
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Kotani Tomomi, Tsuda Hiroyuki, Ito Yumiko, Nakamura Noriyuki, Ushida Takafumi, Imai Kenji, Iitani Yukako, Fuma Kazuya, Muramatsu Yukako, Hayakawa Masahiro, Kajiyama Hiroaki
Vol. 16 ( 1 ) page： 481 2022.12
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Whole-exome analysis of 177 pediatric patients with undiagnosed diseases
Narita Kotaro, Muramatsu Hideki, Narumi Satoshi, Nakamura Yuji, Okuno Yusuke, Suzuki Kyogo, Hamada Motoharu, Yamaguchi Naoya, Suzuki Atsushi, Nishio Yosuke, Shiraki Anna, Yamamori Ayako, Tsumura Yusuke, Sawamura Fumi, Kawaguchi Masahiro, Wakamatsu Manabu, Kataoka Shinsuke, Kato Kohji, Asada Hideyuki, Kubota Tetsuo, Muramatsu Yukako, Kidokoro Hiroyuki, Natsume Jun, Mizuno Seiji, Nakata Tomohiko, Inagaki Hidehito, Ishihara Naoko, Yonekawa Takahiro, Okumura Akihisa, Ogi Tomoo, Kojima Seiji, Kaname Tadashi, Hasegawa Tomonobu, Saitoh Shinji, Takahashi Yoshiyuki
Vol. 12 ( 1 ) page： 14589 2022.8
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Mariya Tasuku, Kato Takema, Sugimoto Takeshi, Miyai Syunsuke, Inagaki Hidehito, Ohye Tamae, Sugihara Eiji, Muramatsu Yukako, Mizuno Seiji, Kurahashi Hiroki
JOURNAL OF HUMAN GENETICS Vol. 67 ( 6 ) page： 363 - 368 2022.6
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Nishida, Y; Ikuta, K; Natsume, A; Ishihara, N; Morikawa, M; Kidokoro, H; Muramatsu, Y; Nonobe, N; Ishizuka, K; Takeichi, T; Kanbe, M; Mizuno, S; Imagama, S; Ozaki, N
SCIENTIFIC REPORTS Vol. 11 ( 1 ) page： 11933 2021.6
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Kato, T; Inagaki, H; Miyai, S; Suzuki, F; Naru, Y; Shinkai, Y; Kato, A; Kanyama, K; Mizuno, S; Muramatsu, Y; Yamamoto, T; Shinya, M; Tazaki, Y; Hiwatashi, S; Ikeda, T; Ozaki, M; Kurahashi, H
HUMAN GENETICS Vol. 139 ( 11 ) page： 1417 - 1427 2020.11
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A case report of rare <i>ZC4H2</i>-associated disorders associated with three large hernias
Nagara, S; Fukaya, S; Muramatsu, Y; Kaname, T; Tanaka, T
PEDIATRICS INTERNATIONAL Vol. 62 ( 8 ) page： 985 - 986 2020.8
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Role of the Embodied Cognition Process in Perspective-Taking Ability During Childhood. Reviewed
Hirai M, Muramatsu Y, Nakamura M
Child development Vol. 91 ( 1 ) page： 214 - 235 2020.1
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Ishiguro, T; Sugiyama, Y; Ueda, K; Muramatsu, Y; Tsuda, H; Kotani, T; Michigami, T; Tachikawa, K; Akiyama, T; Hayakawa, M
BRAIN & DEVELOPMENT Vol. 41 ( 8 ) page： 721 - 725 2019.9
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Factors related to survival discharge in trisomy 18: A retrospective multicenter study
Kato, E; Kitase, Y; Tachibana, T; Hattori, T; Saito, A; Muramatsu, Y; Takemoto, K; Yamamoto, H; Hayashi, S; Yasuda, A; Kato, Y; Ieda, K; Oshiro, M; Sato, Y; Hayakawa, M
AMERICAN JOURNAL OF MEDICAL GENETICS PART A Vol. 179 ( 7 ) page： 1253 - 1259 2019.7
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Recovery from Rapid deterioration in individuals with Down syndrome
Mizuno, S; Inaba, M; Taniai, H; Muramatsu, Y
EUROPEAN JOURNAL OF HUMAN GENETICS Vol. 26 page： 927 - 927 2018.10
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Factors related to home health-care transition in trisomy 13
Kitase Yuma, Hayakawa Masahiro, Kondo Taiki, Saito Akiko, Tachibana Takashi, Oshiro Makoto, Ieda Kuniko, Kato Eiko, Kato Yuichi, Hattori Tetsuo, Hayashi Seiji, Ito Masatoki, Hyodo Reina, Muramatsu Yukako, Sato Yoshiaki
AMERICAN JOURNAL OF MEDICAL GENETICS PART A Vol. 173 ( 10 ) page： 2635 - 2640 2017.10
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Tanigawa Junpei, Mimatsu Haruka, Mizuno Seiji, Okamoto Nobuhiko, Fukushi Daisuke, Tominaga Koji, Kidokoro Hiroyuki, Muramatsu Yukako, Nishi Eriko, Nakamura Shota, Motooka Daisuke, Nomura Noriko, Hayasaka Kiyoshi, Niihori Tetsuya, Aoki Yoko, Nabatame Shin, Hayakawa Masahiro, Natsume Jun, Ozono Keiichi, Kinoshita Taroh, Wakamatsu Nobuaki, Murakami Yoshiko
HUMAN MUTATION Vol. 38 ( 7 ) page： 805 - 815 2017.7
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Muramatsu Yukako, Tokita Yoshihito, Mizuno Seiji, Nakamura Miho
BRAIN & DEVELOPMENT Vol. 39 ( 2 ) page： 145 - 153 2017.2
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Preserved search asymmetry in the detection of fearful faces among neutral faces in individuals with Williams syndrome revealed by measurement of both manual responses and eye tracking. Reviewed
Hirai M, Muramatsu Y, Mizuno S, Kurahashi N, Kurahashi H, Nakamura M
Journal of neurodevelopmental disorders Vol. 9 page： 8 2017
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Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats. Reviewed
Muramatsu Y, Ito M, Oshima T, Kojima S, Ohno K.
Pediatr Pulmonol Vol. 51 ( 9 ) page： 928-35 2016.9
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Cognitive and linguistic abilities of a boy with PVL showing relatively higher VIQ compared to PIQ Reviewed
Muramatsu Y., Natsume J., Nakamura M.
No to hattatsu Vol. 46 ( 5 ) page： 363-369 2015.9
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Developmental changes in mental rotation ability and visual perspective-taking in children and adults with Williams syndrome Reviewed
Hirai M, Muramatsu Y, Mizuno S, Kurahashi N, Kurahashi H, Nakamura M
Front Hum Neurosci page： 856 2013.12
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Prenatal diagnosis of X-linked recessive Lenz microphthalmia syndrome Reviewed
Suzumori N, Kaname T, Muramatsu Y, Yanagi K, Kumagai K, Mizuno S, Naritomi K, Saitoh S, Sugiura-Ogasawara M
J Obstet Gynaecol Res page： 1545-7 2013.11
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Progressive Aortic Root and Pulmonary Artery Aneurysms in a Neonate with Loeys-Dietz Syndrome, Type 1B Reviewed
Yukako Muramatsu, Tomoki kosho, Miyuki Magota, Taro Yokotsuka, Masatoki Ito, Ayako Yasuda, Osamu Kito, Chizuko Suzuki, Yoshie Nagata, Satoru Kawai, Masanobu Ikoma, Tameo Hatano, Masato Nakayama, Keiko Wakui, Hiroko Morisaki, Takayuki Morisaki, Yoshimitsu Fukushima
American Journal of Medical Genetics page： 417-21 2010.2
Books 14
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最新ガイドライン準拠 小児科診断・治療指針 改訂第３版
（ Role： Contributor , 22q11.2 欠失症候群）
中山書店 2024
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マタニティサイクルにおける母子の健康と看護 第7版
（先天異常、新生児の外科系疾患）
メヂカルフレンド社 2022
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発達段階からみた小児看護過程＋病態関連図 第4版
村松友佳子、早川昌弘（ Role： Contributor , 口唇口蓋裂）
医学書院 2021
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今日の小児治療指針 第17版
村松友佳子（ Role： Contributor , Marfan症候群）
医学書院 2020
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マタニティサイクルにおける母子の健康と看護 第6版
（先天異常、新生児の外科系疾患）
メヂカルフレンド社 2019
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こどもと家族のケア12巻4号
村松友佳子（ Role： Contributor , 染色体異常）
日総研出版 2017
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発達段階からみた小児看護過程＋病態関連図 第3版
村松友佳子、早川昌弘（ Role： Contributor , 口唇口蓋裂）
医学書院 2017
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発達障害白書2017年度版
村松友佳子（ Role： Contributor , 発達障害と遺伝カウンセリング）
明石書店 2016
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こどもの病気 遺伝について聞かれたら
村松友佳子、早川昌弘（ Role： Contributor , 新生児けいれん）
診断と治療社 2015
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今日の小児治療指針第16版
村松友佳子（染色体異常、奇形症候群 Williams症候群）
医学書院 2015
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小児疾患診療のための病態生理2 改訂第5版
村松友佳子（ Role： Contributor , Ⅲ.染色体異常、先天異常 Williams症候群）
東京医学社 2015
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神経症候群(第2版)
村松友佳子（ Role： Contributor , その他の神経疾患を含めて 先天異常/先天奇形 染色体異常・先天奇形症候群 Williams症候群(Williams-Beuren症候群)）
日本臨床 2014
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小児科臨床66巻増刊
村松友佳子（ Role： Contributor , 臨床医が知っておきたい先天異常 染色体微細コピー数異常 Williams症候群）
日本小児医事出版社 2013
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臨床新生児ナーシングガイド
村松友佳子（ Role： Contributor , 体温管理）
日総研出版 2005
Presentations 4
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Liberal Arts Education in Japanese Medical Education. International conference
Muramatsu Y, Nishigori H.
Asia Pacific Medical Education Conference 2022 2022.1.14
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Ring chromosome 9 with a 9p24.3-p24.1 deletion and 9p24.1-p21.1 duplication in a girl with developmental delay and sex reversal. International conference
Muramatsu Y, Ohye T, Nakata T, Hamajima T, Ito M, Takeuchi T, Izawa M, Kurahashi H
The 13th International Congress of Human Genetics
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Heterozygosity of ELN can cause tortuous cerebral artery in Williams syndrome. International conference
Muramatsu Y, Mizuno S, Kakizawa H, Shimizu K, Ohashi H, Hayashi S, Inazawa J, Itomi K
European Human Genetics Conference 2015
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Atypical interstitial deletion of 7q11.23 containing whole ELN and partial LIMK1: Phenotype comparison with typical Williams syndrome. International conference
Muramatsu Y., Kakizawa H., Shimizu K., Ohashi H., Hayashi S., Inazawa J., Mizuno S.
European Human Genetics Conference 2013
Research Project for Joint Research, Competitive Funding, etc. 2
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先天性横隔膜ヘルニアにおける肺画像と呼吸機能予後についての経時的検討
2023
令和４年度研究奨励
Authorship：Principal investigator
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幹細胞を用いた新生児敗血症による多臓器障害に対する治療薬の開発
2016
奨学寄附
Authorship：Principal investigator
KAKENHI (Grants-in-Aid for Scientific Research) 5
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胎児炎症性反応症候群に伴う臓器障害の病態解明と幹細胞を用いた新規治療法開発
Grant number：23K07330 2023.4 - 2026.3
科学研究費助成事業 基盤研究(C)
村松 友佳子
Authorship：Principal investigator
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
早産児の合併症の重要な原因の一つとして、胎児炎症性反応症候群（FIRS）が注目されている。FIRSは子宮内で生じた炎症ならびに高サイトカイン状態が、胎児の複数の臓器へ障害をもたらす病態である。FIRSに関する研究の多くは病態解明を目的とした基礎研究に留まり、その治療法は未だ確立されていない。
本研究では、FIRSモデルに対して細胞を投与し、細胞がもたらす抗炎症作用や組織修復促進作用の機序、有効性、安全性を明らかにする。さらに、これらの基礎データから、複数の障害臓器へ同時に治療効果を発揮する細胞療法開発につなげる。 -
A Study of Social Development and Family Mental Health of Preterm Infants
Grant number：20H01768 2020.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s)
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A Study of Social Development and Family Mental Health of Preterm Infants
Grant number：23K20197 2020.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s)
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Grant number：20K16920 2020.4 - 2023.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Muramatsu Yukako
Authorship：Principal investigator
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
Chronic lung disease is one of major complications in extremely low birth weight infants, which is caused by high concentrations of oxygen and/or positive pressure ventilation, but its neurodevelopmental effects are not understood.
Loop diuretics are often used as adjunctive therapy for chronic lung disease (CLD). Loop diuretics inhibit both KCC2 and NKCC1, Cl- transporters present in neuronal membranes. Immature neurons are NKCC1-dominant, but as they mature, they change to KCC2-dominant.
In this study, we investigated the effects of CLD and loop diuretics on KCC2/NKCC1 expression and elucidated the resulting neurodevelopmental consequences. -
Elucidation of the pathogenesis of neurological deficits associated with neonatal chronic lung disease and development of novel therapeutic strategies using cells
Grant number：18K15705 2018.4 - 2020.3
Grant-in-Aid for Early-Career Scientists
Muramatsu Yukako
Authorship：Principal investigator
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
Chronic lung disease (CLD) is a serious and frequent complication in neonatal medicine. The neurodevelopmental delay seen in the patients with CLD is an one of the most important problem, and there are no treatments for the neurological consequences of CLD.
The purpose of this study is to investigate the pathogenesis of the neurological consequences in detail and to conduct basic research that will lead to novel treatments.
Teaching Experience (On-campus) 3
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看護師特定行為研修
2019年〜
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臨床実習１
2016年〜
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臨床実習２
2015年〜
Academic Activities 2
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第44回日本小児遺伝学会学術集会
Role(s)：Peer review
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第45回日本小児遺伝学会学術集会
Role(s)：Planning, management, etc., Peer review