Updated on 2022/03/30

写真a

 
IGUCHI Mitsutaka
 
Organization
Nagoya University Hospital Center of National University Hospital for Infection Control Assistant Professor
Graduate School
Graduate School of Medicine
Title
Assistant Professor
External link

Degree 1

  1. 学士(医学) ( 2002.3   名古屋大学 ) 

Research Areas 2

  1. Life Science / Infectious disease medicine

  2. Life Science / Infectious disease medicine

 

Papers 30

  1. Epidemiology and molecular characterization of fecal carriage of third-generation cephalosporin-resistant Enterobacterales among elderly residents in Japan. Reviewed

    Nakai M, Oka K, Watanabe G, Kamei K, Tsukada N, Mori R, Nagaya M, Ukai Y, Morioka H, Tetsuka N, Iguchi M, Yagi T

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   Vol. 28 ( 4 ) page: 569 - 575   2022.4

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    DOI: 10.1016/j.jiac.2021.12.033

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  2. Difficulties in diagnosing Malassezia furfur bloodstream infection and possibility of spontaneous resolution in a patient undergoing chemotherapy for neuroblastoma: A case report. Reviewed

    Tetsuka N, Muramatsu H, Iguchi M, Oka K, Morioka H, Takahashi Y, Yagi T

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy     2022.3

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    DOI: 10.1016/j.jiac.2022.02.026

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  3. Risk factors for antibiotic resistance in hospital-acquired and ventilator-associated pneumonia. Reviewed

    Sano M, Shindo Y, Takahashi K, Okumura J, Sakakibara T, Murakami Y, Iguchi M, Yagi T, Matsui S, Hasegawa Y

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy     2022.2

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    DOI: 10.1016/j.jiac.2022.02.012

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  4. Lysinibacillus fusiformis bacteremia: Case report and literature review Reviewed

    Morioka Hiroshi, Oka Keisuke, Yamada Yosuke, Nakane Yoshimasa, Komiya Hitoshi, Murase Chiaki, Iguchi Mitsutaka, Yagi Tetsuya

    JOURNAL OF INFECTION AND CHEMOTHERAPY   Vol. 28 ( 2 ) page: 315 - 318   2022.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jiac.2021.10.030

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  5. A Case Report of Bursitis, Bacteremia, and Disseminated Infection of Mycobacteroides (Mycobacterium) abscessus subsp. massiliense.

    Keisuke Oka, Hiroshi Morioka, Motoki Eguchi, Yoshitaka Sato, Nobuyuki Tetsuka, Mitsutaka Iguchi, Takeshi Kanematsu, Hanako Fukano, Yoshihiko Hoshino, Hitoshi Kiyoi, Tetsuya Yagi

    Internal medicine (Tokyo, Japan)   Vol. 60 ( 18 ) page: 3041 - 3045   2021

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society of Internal Medicine  

    We herein report a 59-year-old woman with a 2-year history of chronic bursitis of the hand who took 50 mg/day prednisolone for several autoimmune diseases. Mycobacteroides abscessus subsp. massiliense was isolated from the abscess and blood culture. Combination therapy (imipenem/cilastatin, amikacin, and clarithromycin) was administered for a month. Two months later, M. massiliense was detected from a blood culture again, and disseminated lesions were found. Clarithromycin and sitafloxacin were administered following eight weeks of the same regimen. Six months after the diagnosis, M. massiliense was isolated from a blood culture, and she expired due to multiple organ failure.

    DOI: 10.2169/internalmedicine.6189-20

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    CiNii Research

  6. Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days. Reviewed

    Yoshitaka Sato, Mitsutaka Iguchi, Yoshiaki Kato, Hiroshi Morioka, Aki Hirabayashi, Nobuyuki Tetsuka, Yuka Tomita, Daizo Kato, Kiyofumi Yamada, Hiroshi Kimura, Tetsuya Yagi

    Nagoya journal of medical science   Vol. 82 ( 3 ) page: 407 - 414   2020.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Prolonged treatment with linezolid (LZD) is known to cause thrombocytopenia. However, some patients do not develop thrombocytopenia despite long-term administration of LZD. To determine the risk factors for LZD-associated thrombocytopenia in patients undergoing long-term LZD therapy, we conducted a retrospective cohort study among 212 patients receiving LZD treatment between December 2011 and June 2014 at a tertiary referral university hospital in Nagoya, Japan. Of the 217 patients who received LZD, 37 were treated with LZD for more than 14 days and were enrolled in the study. We compared data on demographic characteristics, underlying disease, microbiology, concomitant drugs, and laboratory tests between the thrombocytopenia group and the non-thrombocytopenia group. Thrombocytopenia was defined as having a platelet count < 100 × 103/μL or a ≥ 50% reduction in platelet count compared to baseline. Among the 37 patients who received LZD for more than 14 days, 17 (45.9%) developed thrombocytopenia. Multivariate logistic regression revealed that both the number of concomitant drugs with thrombocytopenic adverse effects (DTADE) (OR = 1.690; 95% CI = 1.037-2.754; P = 0.035) and a small decrease in the level of C-reactive protein (CRP) 14 days post-administration (OR = 0.965; 95% CI = 0.939-0.993; P = 0.013) were associated with thrombocytopenia during long-term LZD therapy. Therefore, the number of concomitant DTADE and a small decrease in CRP on the 14th day of treatment were key factors for the appearance of LZD-associated thrombocytopenia in patients with long-term LZD therapy. Our findings may be useful for preventing thrombocytopenia in patients treated with LZD for longer than 14 days.

    DOI: 10.18999/nagjms.82.3.407

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  7. Molecular epidemiological analysis and risk factors for acquisition of carbapenemase-producing Enterobacter cloacae complex in a Japanese university hospital. Reviewed International journal

    Nobuyuki Tetsuka, Aki Hirabayashi, Akane Matsumoto, Keisuke Oka, Yuki Hara, Hiroshi Morioka, Mitsutaka Iguchi, Yuka Tomita, Masato Suzuki, Keigo Shibayama, Tetsuya Yagi

    Antimicrobial resistance and infection control   Vol. 8   page: 126 - 126   2019.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Background: To clarify the molecular epidemiology of carbapenem-resistant Enterobacter cloacae complex (CREC) and the risk factors for acquisition of carbapenemase-producing E. cloacae complex (CPEC). Methods: Using clinical CREC isolates detected in a Japanese university hospital over 4 years, carbapenemase production was screened with phenotypic methods. Carbapenemase genes were analysed by PCR and sequencing. Molecular epidemiological analyses were conducted with repetitive extragenic palindromic (REP)-PCR and multilocus sequence typing (MLST). CRECs were identified to the subspecies level by hsp60 sequencing. Whole-genome sequencing of plasmids was conducted. A case-control study was performed to identify risk factors for acquisition of CPEC among patients with CREC. Results: Thirty-nine CRECs including 20 CPECs carrying blaIMP-1 were identified. Patients with CPEC had longer hospital stay before detection (26.5 days vs. 12 days, p = 0.008), a urinary catheter (odds ratio [OR], 5.36; 95% confidence interval [CI], 1.14-30.9; p = 0.023), or intubation (OR, 7.53; 95% CI, 1.47-53.8; p = 0.008) compared to patients without CPEC. Four genetically closely related CPEC clusters were observed, which showed that three of four CPEC clusters corresponded to E. asburiae (ST 53), E. hormaechei subsp. steigerwaltii (ST 113 and ST 1047) and E. cloacae subsp. cloacae (ST 513) by MLST and hsp60 sequencing. Seven representative plasmids shared structures with class I integron containing blaIMP-1 and IncHI2A replicon type. Conclusions: A longer hospital stay, presence of a urinary catheter, and intubation are risk factors for CPEC acquisition. In addition to horizontal transmission of genetically indistinguishable CPECs, IncHI2A plasmid carrying blaIMP-1 appeared to be transferred among genetically different ECs.

    DOI: 10.1186/s13756-019-0578-3

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  8. Automated detection of outbreaks of antimicrobial-resistant bacteria in Japan Reviewed International coauthorship International journal

    Tsutsui A., Yahara K., Clark A., Fujimoto K., Kawakami S., Chikumi H., Iguchi M., Yagi T., Baker M. A., O'Brien T., Stelling J.

    JOURNAL OF HOSPITAL INFECTION   Vol. 102 ( 2 ) page: 226 - 233   2019.6

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    DOI: 10.1016/j.jhin.2018.10.005

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  9. Active surveillance in response to the identification of a single carbapenemase-producing Escherichia coli at a Japanese university hospital. Reviewed International journal

    Daizo Kato, Hiroshi Morioka, Yuka Tomita, Mitsutaka Iguchi, Aki Hirabayashi, Noriyuki Tetsuka, Takuya Sadomoto, Miyuki Hyodo, Mariko Mochizuki, Yukari Osada, Masato Yamamoto, Yoshiaki Kato, Takayuki Inagaki, Kazuya Ichikawa, Tetsuya Yagi

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   Vol. 24 ( 12 ) page: 1013 - 1015   2018.12

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    This report described the experience of active surveillance culture implemented in response to the identification of a single carbapenemase-producing Escherichia coli in a Japanese university hospital. It revealed a horizontal transmission event and an additional asymptomatic carrier of carbapenemase-producing Escherichia coli with unique drug susceptibility and resistance gene profiles. Early implementation of active surveillance culture as a part of multifaceted infection control measures appeared to be useful to control further transmission of carbapenemase-producing Escherichia coli even in the low endemic facility. Further investigations on the timing and usefulness of active surveillance culture in the control of carbapenemase-producing Enterobacteriaceae would be warranted.

    DOI: 10.1016/j.jiac.2018.05.013

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  10. Fungal endocarditis after transcatheter aortic valve replacement (TAVR): Case report and review of literature. Reviewed

    Morioka H, Tokuda Y, Oshima H, Iguchi M, Tomita Y, Usui A, Yagi T

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy     2018.9

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    DOI: 10.1016/j.jiac.2018.08.017

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  11. The first multi-centre point-prevalence survey in four Japanese university hospitals Reviewed

    Morioka H., Nagao M., Yoshihara S., Ohge H., Kasahara K., Shigemoto N., Kajihara T., Mori M., Iguchi M., Tomita Y., Ichiyama S., Yagi T.

    JOURNAL OF HOSPITAL INFECTION   Vol. 99 ( 3 ) page: 325-331   2018.7

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    DOI: 10.1016/j.jhin.2018.03.005

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  12. カルバペネム耐性腸内細菌科細菌(CRE)

    井口 光孝, 八木 哲也

    月間薬事 1月臨時増刊号   Vol. 60   page: 157 - 165   2018

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  13. Risk factors for and role of OprD protein in increasing minimal inhibitory concentrations of carbapenems in clinical isolates of Pseudomonas aeruginosa. Reviewed International journal

    Aki Hirabayashi, Daizo Kato, Yuka Tomita, Mitsutaka Iguchi, Keiko Yamada, Yuichi Kouyama, Hiroshi Morioka, Nobuyuki Tetsuka, Tetsuya Yagi

    Journal of medical microbiology   Vol. 66 ( 11 ) page: 1562 - 1572   2017.11

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    PURPOSE: This study examined the risk factors for, and molecular mechanisms underlying, the increase in carbapenem minimum inhibitory concentrations (MICs) in clinical isolates of Pseudomonas aeruginosa. METHODOLOGY: Consecutive clinical isolates of P. aeruginosa were collected. The MicroScan WalkAway system detected more than fourfold increases in the MICs of carbapenems in P. aeruginosa isolates serially recovered from some patients during their clinical course. The clinical risk factors associated with this increase were examined by multiple logistic regression analysis. Western blot analysis and nucleotide sequencing of the oprD gene of 19 clonally related and paired P. aeruginosa isolates from the same patients were undertaken to examine the mechanisms underlying the increase in MICs. RESULTS: The results showed that prior use of carbapenems (OR, 2.799; 95 % CI, 1.088-7.200; P=0.033) and the use of ventilators or tracheostomies (OR, 2.648; 95 % CI, 1.051-6.671; P=0.039) were risk factors for increased carbapenem MICs. Analysis of the underlying mechanisms revealed that loss of functional OprD protein due to mutation of the oprD gene tended to occur in P. aeruginosa isolates with imipenem MICs of more than 8 µg ml-1; a reduction in OprD expression was observed in P. aeruginosa isolates with imipenem MICs of 4 or 8 µg ml-1. This difference in the resistance mechanism was not correlated with the MICs of meropenem. CONCLUSION: This difference in the resistance mechanism of P. aeruginosa indicates a critical breakpoint at an imipenem MIC of 8 µg ml-1, in accordance with EUCAST criteria. Reducing carbapenem use will prevent P. aeruginosa clinical isolates from developing resistance to carbapenems.

    DOI: 10.1099/jmm.0.000601

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  14. Appropriateness of surgical prophylaxis contributed to significant reduction of oral cephalosporins in a Japanese university hospital Reviewed

    Morioka Hiroshi, Kato Yoshiaki, Inagaki Takayuki, Tetsuka Nobuyuki, Iguchi Mitsutaka, Tomita Yuka, Yagi Tetsuya

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   Vol. 50   page: S42-S43   2017.11

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  15. Recurrent bacteremia and liver abscess caused by Clostridium difficile: A case report. Reviewed International journal

    Hiroshi Morioka, Mitsutaka Iguchi, Teiji Kuzuya, Hiroshige Mikamo, Tetsuya Yagi

    Medicine   Vol. 96 ( 35 ) page: e7969   2017.9

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    RATIONALE: Clostridium difficile bacteremia (CDB) and liver abscess is a quite rare presentation of C. difficile infection. PATIENTS CONCERNS: A 74-year-old male with primary biliary cirrhosis and hepatocellular carcinoma who underwent transarterial chemoembolization (TACE) developed a high fever on post-TACE day 14. Intravenous ceftriaxone and following meropenem were administered, however, his clinical response was poor. On post-TACE day 24, 2 sets of blood culture were taken due to elevation of C-reactive protein levels. DIAGNOSIS: CDB, caused by bacterial translocation. INTERVENTIONS: Intravenous vancomycin and oral metronidazole were administered for two weeks. OUTCOMES: One month after recurrent CDB, the patient was re-admitted due to a liver abscess at the same site of TACE. C. difficile was isolated from the liver abscess and the patient received 6 weeks of oral metronidazole treatment. CDB and liver abscess have not recurred since completion of antibiotic treatment. LESSONS: The spore-forming ability of C. difficile may contributed to the recurrent CDB episodes and liver abscess formation in necrotic liver tissue following TACE, and long-term metronidazole therapy was considered to be effective to C. difficile liver abscess.

    DOI: 10.1097/MD.0000000000007969

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  16. Pneumococcal biliary tract infections - How rare are they? Reviewed International journal

    Hiroshi Morioka, Mitsutaka Iguchi, Mitsuru Oodate, Masaki Yoneda, Futoshi Ushijima, Aki Hirabayashi, Nobuyuki Tetsuka, Yuka Tomita, Daizo Kato, Tetsuya Yagi

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   Vol. 23 ( 5-6 ) page: 415 - 418   2017

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    Pneumococcal biliary tract infections (PBTIs) were reported as rare due to the bacterium's bile solubility. The purpose of this study was to determine the occurrence and clinical characteristics of PBTIs. A retrospective case series review was conducted from January 2006 to August 2014 at a tertiary referral university hospital in Japan. Patients with a blood or bile culture positive for Streptococcus pneumoniae diagnosed with definite cholangitis or cholecystitis according to Tokyo Guideline 2013 were enrolled in this study. Data on clinical information, treatments, and outcomes were collected. During 104 months, 48 cases of positive blood cultures and 13 cases of positive bile cultures were recorded, and after excluding 43 and 5 of these, respectively, a total of 10 patients were diagnosed with PBTI. Most patients (9/10) had biliary tract problems and biliary devices in place. PBTIs were not rare; conversely, they were a relatively common cause of pneumococcal bacteremia in this center treating a high volume of biliary tract illnesses.

    DOI: 10.1016/j.jiac.2016.11.008

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  17. Procalcitonin evaluation in the diagnosis of bacteremia: a retrospective observational study

    Hatano Toshiyuki, Matsuda Naoyuki, Iguchi Mitsutaka, Yagi Tetsuya, Ejima Tadashi, U. Adachi Yushi, Numaguchi Atsushi

    Journal of the Japanese Society of Intensive Care Medicine   Vol. 24 ( 2 ) page: 115 - 120   2017

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    <B>Objectives:</B> To evaluate the usefulness of procalcitonin (PCT) in differential diagnosis for bacteremia or blood culture contamination and predicting either Gram-positive or Gram-negative bacteremia. <B>Methods:</B> We retrospectively reviewed a total of 132 cases in which PCT and C-reactive protein (CRP) were examined and blood cultures were found to be positive from November 2012 to June 2013. <B>Results:</B> The PCT concentrations were significantly higher in bacteremia cases (n=102) than in contamination cases (n=30) (median: 2.8 ng/m<I>l</I> vs. 0.3 ng/m<I>l</I>, <I>P</I><0.001). The receiver operating characteristics-areas under the curve (ROC-AUCs) of PCT and CRP for discriminating bacteremia from contamination were 0.76 and 0.64, respectively. PCT concentrations of Gram-positive cases (n=48) were not significantly different from those of Gram-negative cases (n=54) (median: 2.1 ng/m<I>l</I> vs. 3.7 ng/m<I>l</I>, <I>P</I>=0.123). <B>Conclusions:</B> Compared with CRP, PCT could be useful in the differential diagnosis between bacteremia and contamination. However, we may not estimate either Gram-positive or Gram-negative bacteremia using CRP and PCT.

    DOI: 10.3918/jsicm.24_115

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  18. 感染症対策update-ひろげない,ふやさない,もらわない 病原体をひろげないための方策 デバイス関連感染症の予防 Reviewed

    森岡 悠, 井口 光孝

    内科   Vol. 118 ( 5 ) page: 885 - 889   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:南江堂  

    DOI: 10.15106/j00974.2017009426

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  19. The first point prevalence survey of health care-associated infection and antimicrobial use in a Japanese university hospital: A pilot study. Reviewed International journal

    Hiroshi Morioka, Aki Hirabayashi, Mitsutaka Iguchi, Yuka Tomita, Daizo Kato, Naokazu Sato, Miyuki Hyodo, Naoko Kawamura, Takuya Sadomoto, Kazuya Ichikawa, Takayuki Inagaki, Yoshiaki Kato, Yuichi Kouyama, Yoshinori Ito, Tetsuya Yagi

    American journal of infection control   Vol. 44 ( 7 ) page: E119 - E123   2016.7

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    BACKGROUND: Point prevalence surveys (PPSs) in Japanese hospitals have not yet been reported. The purpose of this pilot PPS study was to evaluate the epidemiology of health care-associated infections (HAIs) and antimicrobial use in a Japanese tertiary university hospital. METHODS: A 1-day, cross-sectional PPS was performed at a Japanese university hospital. Data on demographics, active HAIs, and antimicrobial use of all inpatients were collected using a data collection form. RESULTS: Of 841 patients, 85 (10.1%) had 90 active HAIs, and 308 patients (36.6%) were administered 494 antimicrobials. Among the 90 HAIs and 58 pathogens, the most frequent infection and isolated pathogen were pneumonia (20.0%) and Enterobacteriaceae (27.6%), respectively. Of the 118 antimicrobials used for treatment of HAIs, carbapenems were the most frequently administered category of antimicrobials (22.9%). In regard to antimicrobials for surgical prophylaxis, 37 of 119 (31.1%) were administered to patients on postoperative day 3 or later, and 48 of 119 (40.3%) were administered orally. CONCLUSIONS: The incidence of HAIs is higher than in other developed countries. The social and medical situation in Japan may affect patient demographics, active HAIs, and antimicrobial use. Multicenter PPSs are necessary to uncover the real epidemiology of HAIs and antimicrobial use in Japan.

    DOI: 10.1016/j.ajic.2016.03.045

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  20. P0578-22-AM 注射用抗菌薬届出システムの構築と適正使用に向けた介入方法の検討(感染制御(その他)1,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-) Reviewed

    加藤 善章, 八木 哲也, 山田 清文, 山本 雅人, 稲垣 孝行, 手塚 宜行, 森岡 悠, 平林 亜希, 井口 光孝, 加藤 大三, 冨田 ゆうか

    日本医療薬学会年会講演要旨集   Vol. 25 ( 0 )   2015

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    DOI: 10.20825/amjsphcs.25.0_362_2

  21. [Multicenter surveillance of Pseudomonas aeruginosa strains for antimicrobials in Aichi prefecture in 2009]. Reviewed

    Mitsutaka Iguchi, Mariko Mochizuki, Tetsuya Yagi, Hironaga Ookawa, Yutaka Shimazaki, Yumiko Ootsuka, Kazuya Sato, Arufumi Shiota, Naoki Wakiyama, Atsushi Nakamura, Mariko Kidono, Yuki Hara, Sachie Asai, Makoto Kawashima, Kazuko Sakuragi, Jitsuko Asahi, Hitoshi Murase, Mitsuru Nishio, Yuki Miyaki, Keiji Funahashi, Tetsuo Mouri, Yasuyuki Sugiura, Takako Yamada, Konomi Kondo, Kaori Sahara, Yoshiko Sugaki, Atsushi Kawabata, Yumi Itou, Yu Yamamoto, Keiko Kinoshita, Ikuo Yamaguchi, Masaaki Sasano, Tomomi Inukai, Natsuko Matsui, Hitoshi Kuramae, Masaru Okugawa, Hiroki Kawai, Motohiro Shibata, Kazuhisa Inuzuka, Atsuko Yamada, Isao Koita, Hiroyuki Suematsu, Haruki Sawamura, Yuka Yamagishi, Hiroshige Mikamo

    The Japanese journal of antibiotics   Vol. 66 ( 4 ) page: 211 - 25   2013.8

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    We investigated the susceptibility to antimicrobials of 204 Pseudomonas aeruginosa strains isolated from 21 hospitals in Aichi prefecture from September to November 2009. MIC distributions of various antimicrobials were analyzed in terms of geographic region of isolation, patient status (outpatient or inpatient), and type of specimens that the strain was isolated from. The results were as follows. 1. Although more than 90% of strains were susceptible to all aminoglycosides and colistin, 80-90% of them were susceptible to beta-lactams and fluoroquinolones. MIC distributions of all antimicrobials measured were not significantly different between regions. 2. Only 1 strain (0.5%) was multi-drug resistant Pseudomonas aeruginosa (MDRP). Thirteen strains (6.4%) showed imipenem MIC > or = 16 microg/mL, and 16 strains (7.8%) showed ciprofloxacin MIC > or = 4 microg/mL. These strains tended to be more isolated from urine, respiratory tract specimens, or surgical specimens. 3. The MICs of tazobactam/piperacillin, panipenem, meropenem, doripenem, biapenem, sulbactam/cefoperazone, cefepime, and aztreonam were significantly higher in strains isolated from inpatients than in those from outpatients. MIC distributions of antimicrobials other than beta-lactams were not significantly different between situations where strains were isolated. 4. MIC distributions of piperacillin, all carbapenems, cefepime, gentamicin, and all fluoroquinolones were significantly different among samples from which strains were isolated. The strains isolated from blood showed lower MICs against all antimicrobials than those from other samples. No difference was found in MIC distributions when categorized according to bacteremic origin. The MICs were apparently elevated against beta-lactams, fluoroquinolones, and gentamicin in strains isolated from respiratory tract specimens, and against beta-lactams, and fluoroquinolones in strains isolated from urine. It was suggested that in P. aeruginosa surveillance, the results should be reported by stratifying with patient status, and type of specimens that the strain was isolated from and that regional surveillance should be useful with such stratification to establish antibiograms for empirical antimicrobial choice.

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  22. Accuracy of prediction rules and risk factors for mortality in patients with hospital-acquired pneumonia Reviewed

    Ito R., Kobayashi D., Shindo Y., Tomita Y., Iguchi M., Yagi T., Hasegawa Y.

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   Vol. 42   page: S145-S145   2013.6

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  23. Prediction of infection due to antibiotic-resistant bacteria in patients with hospital-associated and ventilator-acquired pneumonia Reviewed

    Kobayashi D., Shindo Y., Ito R., Tomita Y., Iguchi M., Yagi T., Hasegawa Y.

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   Vol. 42   page: S145-S145   2013.6

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  24. 医療介護関連肺炎 市中肺炎および医療ケア関連肺炎患者における耐性菌のリスク因子は共通している:多施設共同前向き観察研究(CJLSG 0911) Reviewed

    進藤 有一郎, 小林 大介, 伊藤 亮太, 白木 晶, 後藤 康洋, 福井 保太, 井口 光孝, 冨田 ゆうか, 岩木 舞, 奥村 隼也, 齋藤 博, 安藤 昌彦, 川村 孝, 長谷川 好規

    日本呼吸器学会誌   Vol. 2 ( 増刊 ) page: 144 - 144   2013.3

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  25. Molecular and clinical characterization of plasmid-mediated AmpC beta-lactamase-producing Escherichia coli bacteraemia: a comparison with extended-spectrum beta-lactamase-producing and non-resistant E.coli bacteraemia Reviewed

    Matsumura Y., Nagao M., Iguchi M., Yagi T., Komori T., Fujita N., Yamamoto M., Matsushima A., Takakura S., Ichiyama S.

    CLINICAL MICROBIOLOGY AND INFECTION   Vol. 19 ( 2 ) page: 161-168   2013.2

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    DOI: 10.1111/j.1469-0691.2012.03762.x

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  26. Cryptococcal cellulitis in a patient with bullous pemphigoid. Reviewed International journal

    Kazumitsu Sugiura, Nana Sugiura, Tetsuya Yagi, Mitsutaka Iguchi, Hideaki Ohno, Yoshitsugu Miyazaki, Masashi Akiyama

    Acta dermato-venereologica   Vol. 93 ( 2 ) page: 187 - 188   2013

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    DOI: 10.2340/00015555-1385

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  27. 特集 いま,内科薬はこう使う 感染症薬 セフェム系第1~4世代,モノバクタム系 Reviewed

    井口 光孝

    medicina   Vol. 49 ( 11 ) page: 407 - 409   2012.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1402106478

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  28. A Study of the Utility of Nutritional Simple Screening on Admission with Only 4 Items at Emergency Care Hospital. Reviewed

    NAKANISHI Toshihiro, TAKEUCHI Yuuki, IGUCHI Mitsutaka, KABEYA Megumi, SHINKI Chieko, KIKUCHI Fumi, UMEMURA Satomi, TADOKORO Fumie, KUNII Satoko, HOSOKAWA Manami

    Jomyaku Keicho Eiyo   Vol. 27 ( 4 ) page: 1079 - 1086   2012

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    [Objectives] Our nutritional screening for the inpatients on admission consists of these four items; equal or less than 80% ideal body weight ratio, pressure sore, oral intake problem include enteral feeding, malnutrition with the appearance. If there are any inpatients with more than one item, we interpret them as malnourished and perform intervention of NST (nutritional support team). We report the utility of our nutritional simple screening on admission (NSSA).<br>[Methods] For all 245 inpatients hospitalized to our medical wards during two months, we independently performed NSSA and subjective global assessment (SGA). We reviewed whether we were able to detect patients with malnutrition by NSSA compared with SGA, physical measurement and blood examinations adequately.<br>[Results] By NSSA, we decided 61 patients needing NST intervention and 184 patients with NST intervention-free. Comparing NST intervention-free patients, NST intervention pivot patients were more undernourished by SGA significantly. Furthermore, serum albumin, % triceps skinfold thickness (%TSF) and % arm muscle circumference (%AMC) of the NST intervention pivot group were lower than NST intervention-free group significantly. The sensitivity and specificity for malnutrition judged by SGA patients of our NSSA were good, which was 87.2% and 86.5% respectively.<br>[Conclusion] Our NSSA shows clinical benefit for its simplicity, because malnutrition patients can be detected adequately.

    DOI: 10.11244/jjspen.27.1079

    CiNii Research

  29. P2-249 当院におけるセフェピム誘発性精神神経症状の発生状況(有害事象・副作用,ポスター,一般演題,岐路に立つ医療~千年紀の目覚め~よみがえれ!ニッポン!薬の改革は我らが手で!) Reviewed

    加藤 善章, 井口 光孝, 山本 雅人, 八木 哲也, 山田 清文

    日本医療薬学会年会講演要旨集   Vol. 22 ( 0 )   2012

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    DOI: 10.20825/amjsphcs.22.0_420_1

  30. 今月の主題 緊急画像トラブルシューティング-内科医のためのPearlとPitfall 感染症を疑ったら 感染症のフォーカス探し Reviewed

    井口 光孝

    medicina   Vol. 48 ( 4 ) page: 616 - 619   2011.4

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    DOI: 10.11477/mf.1402105119

    CiNii Research

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Books 7

  1. AST虎の巻 : 日常の疑問に答える!

    竹末, 芳生( Role: Contributor)

    中外医学社  2020.5  ( ISBN:9784498021303

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    Total pages:iv, 224p   Language:Japanese Book type:Scholarly book

    CiNii Books

  2. 感染症クリスタルエビデンス : こういうときはこうする!

    岡, 秀昭, 加藤, 英明( Role: Contributor)

    金芳堂  2018.4  ( ISBN:9784765317528

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    Total pages:冊   Language:Japanese Book type:Scholarly book

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  3. 抗菌薬・抗微生物薬の選び方・使い方Q&A : スッキリわかる使い分けのコツとポイント

    八木, 哲也, BEAM(Bunkodo Essential & Advanced Mook)編集委員会( Role: Contributor)

    文光堂  2014.8  ( ISBN:9784830681547

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    Total pages:x, 305p   Language:Japanese Book type:Scholarly book

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  4. UCSFに学ぶできる内科医への近道

    山中, 克郎, 澤田, 覚志, 植西, 憲達( Role: Contributor)

    南山堂  2012.10  ( ISBN:9784525201548

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    Total pages:xxvi, 428p   Language:Japanese Book type:Scholarly book

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  5. 外来を愉しむ攻める問診

    山中, 克郎, BEAM編集委員会( Role: Contributor)

    文光堂  2012.4  ( ISBN:9784830681462

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    Total pages:viii, 193p   Language:Japanese Book type:Scholarly book

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  6. ダ・ヴィンチのカルテ : snap diagnosisを鍛える99症例

    山中, 克郎, 佐藤, 泰吾( Role: Contributor)

    シービーアール  2012.1  ( ISBN:9784902470772

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    Total pages:viii, 203p   Language:Japanese Book type:Scholarly book

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  7. 事例で学ぶ感染症診断ストラテジー : 根拠から理解する適切な診断へのアプローチ法 = The strategies for diagnosis of infectious diseases

    馬場, 尚志( Role: Contributor)

    文光堂  2010.3  ( ISBN:9784830620225

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    Total pages:viii, 155p   Language:Japanese Book type:Scholarly book

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MISC 28

  1. Dermabacter jinjuensisによる人工血管使用皮下動静脈瘻感染症の一例 Reviewed

    大西 由莉, 井口 光孝, 千田 澄江, 小柏 均, 土居 美樹, 明壁 均, 長田 ゆかり, 八木 哲也

    日本臨床微生物学会雑誌   Vol. 30 ( 4 ) page: 253 - 257   2020.9

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  2. 良好な経過をたどったIMP-6 metallo-β-lactamase産生Klebsiella pneumoniaeによる化膿性血栓性静脈炎の1例 Reviewed

    市川 佳保里, 井口 光孝, 三谷 有生, 高石 洋子, 青木 隆恵, 八木 哲也

    日本臨床微生物学会雑誌   Vol. 30 ( 2 ) page: 64 - 68   2020.3

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    患者は70歳男性。リハビリテーション目的で前医入院中に発熱・血圧低下が出現し搬送された。右鼠径部には発赤を伴う痂皮と中枢側に伸びる索状物を触れた。造影CTで右大腿静脈内の造影欠損と血管周囲の炎症像を認め化膿性血栓性静脈炎と診断,meropenemが開始された。血液培養よりIMP-6 metallo-β-lactamase産生Klebsiella pneumoniaeを検出。aztreonam,amikacin,tigecyclineによる4週間の治療後sitafloxacinを2週間投与し治療を終了した。化膿性血栓性静脈炎は静脈壁に化膿性炎症を起こし血栓を形成する疾患で,持続性菌血症を呈し難治化しやすい。また,カルバペネマーゼ産生腸内細菌科細菌(CPE)による感染は治療薬の選択肢が限られ難治化のリスクとされている。本例ではカルバペネマーゼ産生を適切に検出し迅速に薬剤感受性検査結果を報告することで,適切な薬剤が選択され良好な転帰に繋がった。(著者抄録)

  3. 感染と脳卒中(臨床) 結核性髄膜炎の病態と診断

    井口 光孝

    The Mt. Fuji Workshop on CVD   Vol. 37   page: 17 - 21   2019.7

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  4. 【何が同じで、どこが違う?現場向けESBL産生菌・CRE(CPE)対策】Important ESBL産生菌・CRE(CPE)対策のための3大知見 両耐性菌の共通・相違の視点から 国内・海外動向の最新知見 現場が知っておくべき疫学の今

    井口 光孝, 八木 哲也

    感染対策ICTジャーナル   Vol. 14 ( 3 ) page: 183 - 188   2019.7

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  5. 【エキスパートに学ぶSepsis敗血症バンドル】実践編 敗血症の管理ポイント 抗菌薬の選択・変更・中止と微生物検査

    井口 光孝

    救急・集中治療   Vol. 30 ( 5 ) page: 729 - 741   2018.10

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    <point>▼正しい敗血症診療には正しい感染症診療が必要。▼敗血症診療の質は、多職種の医療者による体制の整備と絶え間ない連携で向上させることができる。(著者抄録)

  6. 【ここが知りたい耳鼻咽喉科に必要な他科の知識】耳鼻咽喉科領域における周術期抗菌薬の適正使用について

    森岡 悠, 井口 光孝

    ENTONI   ( 221 ) page: 8 - 13   2018.7

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    国内外で薬剤耐性菌が問題となってきており、抗菌薬処方の適正化が強く求められてきている。このような状況下で、周術期に投与すべき薬剤・投与タイミング・投与期間などが記載された「術後感染予防抗菌薬適正使用のための実践ガイドライン」が作成され、周術期抗菌薬投与の指針として使用可能である。また、術後の内服抗菌薬として頻用される第3世代の経口セファロスポリン系薬剤は概して生体内利用率が低く、ガイドラインと照らし合わせても周術期抗菌薬としての投与は不要である。名古屋大学医学部附属病院では、周術期抗菌薬投与の適正化を行ったことで、2013年上半期と比較して、2017年の上半期では耳鼻咽喉科の処方量で71%の第3世代の経口セファロスポリン系薬剤の処方量の削減を行うことができた。本稿では、薬剤耐性対策アクションプランを含めた抗菌薬適正使用の必要性、耳鼻咽喉科での周術期抗菌薬投与の原則、名古屋大学医学部附属病院での取り組みについて概説する。(著者抄録)

  7. 【多剤耐性グラム陰性菌対策を見直す-『薬剤耐性(AMR)対策アクションプラン』に向けて】多剤耐性グラム陰性菌における抗菌薬適正使用 カルバペネム耐性腸内細菌科細菌(CRE)・カルバペネマーゼ産生腸内細菌科細菌(CPE)

    井口 光孝, 八木 哲也

    感染と抗菌薬   Vol. 21 ( 2 ) page: 109 - 116   2018.6

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    「カルバペネム耐性腸内細菌科細菌」の定義は複数あるため、データ解釈時は注意する。カルバペネマーゼ産生腸内細菌科細菌の検出に自施設で実施可能な検査の内容とその限界を把握しておくことが望ましい。カルバペネム耐性腸内細菌科細菌に普遍的に効果的な抗菌薬はなく、感受性検査結果を元に症例ごとに選択する。宿主因子・感染臓器から原因病原体を推定した上で抗菌薬を選択する基本的習慣を身につけることが、抗菌薬の適正使用に繋がる。(著者抄録)

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J03177&link_issn=&doc_id=20180625070006&doc_link_id=10.34426%2FJ03177.2018256910&url=https%3A%2F%2Fdoi.org%2F10.34426%2FJ03177.2018256910&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  8. 【AMR対策につながる抗菌薬の使い方実践ガイド】(第3章)耐性菌の特徴と治療のポイント カルバペネム耐性腸内細菌科細菌(CRE)

    井口 光孝, 八木 哲也

    薬事   Vol. 60 ( 2 ) page: 325 - 333   2018.1

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    <Key Points>「カルバペネム耐性腸内細菌科細菌(CRE)」の定義が複数存在するため、データは注意して解釈する。特に「カルバペネマーゼ産生腸内細菌科細菌」に注意する。自施設で行っている感受性検査やカルバペネマーゼ検出検査について理解しておく。CREに対し一律に効果のある抗菌薬レジメンはなく、個々の感受性検査結果に応じてレジメンを選択する。CREを保菌するリスクを減らすためには、自施設の抗微生物薬の使用量をモニタリングしながら適切なフィードバックを行い、不適切な抗微生物薬投与の減少に努めるAntimicrobial Stewardshipが重要である。(著者抄録)

  9. 血中(1→3)-β-D-グルカン値高値を伴う肺ノカルジア症の1例 Reviewed

    小林 弘典, 島 浩一郎, 平野 晋吾, 米田 一樹, 井口 光孝, 山本 雅史

    日本呼吸器学会誌   Vol. 6 ( 6 ) page: 436 - 440   2017.11

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    症例は関節リウマチ治療中の69歳男性。2013年10月に胸部腫瘤様陰影で当科紹介され気管支鏡検査を行うも確定診断に至らず、11月初旬に発熱と胸部陰影の悪化あり精査加療目的に入院。CTガイド下経皮肺生検により肺ノカルジア症と診断、治療するも永眠された。治療前の検査で血中(1→3)-β-D-グルカン(βDG)値高値を認め各種検査を行うも深在性真菌感染症を疑う所見は認められず、肺ノカルジア症により血中βDG値が上昇していた可能性が考えられた。(著者抄録)

  10. 菌血症診断におけるプロカルシトニンの有効性の検討 Reviewed

    波多野 俊之, 松田 直之, 井口 光孝, 八木 哲也, 江嶋 正志, 足立 裕史, 沼口 敦

    日本集中治療医学会雑誌   Vol. 24 ( 2 ) page: 115 - 120   2017.3

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    【目的】菌血症におけるプロカルシトニン(procalcitonin、PCT)の初期診断での有用性について、後方視的に解析した。【方法】2012年11月から2013年6月までの8ヵ月間において当院で血液培養検査が陽性となりPCTが測定されていた132例を調査対象とし、検出菌、PCTおよびC反応性蛋白(CRP)との関連性を評価した。【結果】感染症専門医により、菌血症102例、contamination(擬陽性)30例と判断された。菌血症と擬陽性でPCT(ng/ml)とCRP(mg/dl)の中央値は、それぞれ2.8と0.3、13.2と7.0であり、菌血症で有意に高かった(P<0.001、P=0.020)。ROC-AUC(receiver operating characteristic-area under the curve)(95%CI)は、PCT 0.76(0.65〜0.86)、CRP 0.64(0.52〜0.76)だった。一方、菌血症の原因菌別でグラム陽性菌(n=48)とグラム陰性菌(n=54)のPCTは、それぞれ2.1と3.7で有意差を認めなかった(P=0.123)。【結論】PCTはCRPと比較して真の菌血症と擬陽性の鑑別に役立つと評価された。しかし、菌血症におけるグラム陽性菌とグラム陰性菌を鑑別できるものではなかった。(著者抄録)

  11. 明日の医療の質向上をリードする医師養成プログラム(ASUISHIプログラム)

    八木 哲也, 井口 光孝

    Infection control : The Japanese journal of infection control   Vol. 25 ( 12 ) page: 1130 - 1132   2016.12

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    CiNii Books

  12. 【感染症対策update-ひろげない,ふやさない,もらわない】病原体をひろげないための方策 デバイス関連感染症の予防

    森岡 悠, 井口 光孝

    内科   Vol. 118 ( 5 ) page: 885 - 889   2016.11

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    デバイス関連感染症は死亡率,入院期間,医療費の増加,薬剤耐性菌選択にもつながる医原性感染症である.デバイス関連感染予防のもっとも重要な点は,留置前にはデバイスの適応の有無を,留置後は抜去可能かどうかを日々検討することである.また,重要な点は,留置時の清潔操作,留置後のケアが重要であり,抗菌薬投与ではない.サーベイランスを行うことで,デバイス関連感染症の発生状況を把握することができ,対策に役立てることが可能である.(著者抄録)

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J00974&link_issn=&doc_id=20161104070007&doc_link_id=issn%3D0022-1961%26volume%3D118%26issue%3D5%26spage%3D885&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0022-1961%26volume%3D118%26issue%3D5%26spage%3D885&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

  13. 【感染症の新しい動向と話題】インフルエンザ(新型を含む)

    井口 光孝

    現代医学   Vol. 64 ( 1 ) page: 17 - 23   2016.6

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    インフルエンザウイルスによって起こされる疾患である、季節性インフルエンザ、鳥インフルエンザ、新型インフルエンザに関して、それらを医学的および医療の観点からみた際の共通点と相違点について述べる。(著者抄録)

  14. P0578-22-AM 注射用抗菌薬届出システムの構築と適正使用に向けた介入方法の検討(感染制御(その他)1,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

    加藤 善章, 山本 雅人, 稲垣 孝行, 手塚 宜行, 森岡 悠, 平林 亜希, 井口 光孝, 加藤 大三, 冨田 ゆうか, 八木 哲也, 山田 清文

    日本医療薬学会年会講演要旨集   Vol. 25 ( 0 ) page: 362   2015.10

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    DOI: 10.20825/amjsphcs.25.0_362_2

    CiNii Research

  15. 経鼻胃管の口径およびランソプラゾール口腔内崩壊錠投与とチューブ閉塞との関連性について Reviewed

    新木 智映子, 井口 光孝, 中西 敏博, 壁谷 めぐみ, 井上 博貴, 田尻 千晴, 田所 史江, 梅村 聡美, 武内 有城

    日本病院薬剤師会雑誌   Vol. 49 ( 3 ) page: 279 - 282   2013.3

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    ランソプラゾール口腔内崩壊錠(以下、LPZ OD錠)の経鼻胃管からの投与がチューブ閉塞に与える影響について臨床的に検討した。2008年1月〜2009年9月に、名古屋記念病院において経鼻胃管を挿入して栄養管理を施行した症例を対象に診療録から後ろ向きに調査した。LPZ OD錠投与群は39例(8Fr.27例、12Fr.12例)、非投与群は48例(8Fr.32例、12Fr.16例)で、閉塞件数は8Fr.使用患者の投与群が非投与群に比して有意に多かった(20.5%vs.8.1%、χ2検定、p<0.05)。経鼻胃管の閉塞率は、8Fr.使用患者は投与群8日目18.8%、15日目26.6%、非投与群8日目6.2%、15日目9.8%で、12Fr.使用患者は両日ともに投与群4.0%、非投与群5.3%で、8Fr.使用患者の投与群の閉塞率が有意に高かった(log-rank検定、p<0.05)。これらの検討よりLPZ OD錠の投与は細径経鼻胃管の閉塞に影響を与える可能性がある。(著者抄録)

  16. 術後感染からtoxic shock syndromeを発症したと考えられた1例 Reviewed

    野坂 和外, 安井 啓晃, 石橋 由妃, 三澤 俊哉, 伊藤 由紀子, 井口 光孝

    東海産科婦人科学会雑誌   Vol. 49   page: 333 - 337   2013.2

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    毒素性ショック症候群(TSS:toxic shock syndrome)はMRSAを含むStaphylococcus aureusなどが産生する毒素(TSST-1:toxic shock syndrome toxin-1)によりT細胞を活性化させ、炎症性サイトカインが分泌されることにより発熱・発疹・低血圧・多臓器不全などを呈し、重症例では死に至ることもある疾患である。今回我々は子宮筋腫に対する腹式単純子宮全摘術後に創感染からTSSに至ったと考えられる症例を経験したので報告する。症例は44歳2経産の有経女性、子宮筋腫による過多月経・貧血のため腹式単純子宮全摘術を施行した。術後2日目より発熱が出現、その後血圧低下・腎機能低下・落屑を伴う紅斑などを順に呈した。薬疹など鑑別に苦慮したが、CDC(Center for Disease Control and Prevention)の診断基準よりTSSの診断に至り、血液透析やバンコマイシン(VCM)などの抗菌薬投与により治療を行い軽快した。術後急速な経過で発熱・ショック・皮疹を呈する場合には、CDC(Center for Disease Control and Prevention)の診断基準に基づいて、早期よりTSSを疑い治療開始することが重要であると考えた。(著者抄録)

  17. 市中肺炎および医療ケア関連肺炎患者における耐性菌のリスク因子は共通している:多施設共同前向き観察研究(CJLSG0911) Reviewed

    進藤有一郎, 小林大介, 伊藤亮太, 白木晶, 後藤康洋, 福井保太, 井口光孝, 冨田ゆうか, 岩木舞, 奥村隼也, 齋藤博, 安藤昌彦, 川村孝, 長谷川好規

    日本呼吸器学会誌   Vol. 2   2013

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    J-GLOBAL

  18. 【いま,内科薬はこう使う】感染症薬 セフェム系第1〜4世代,モノバクタム系

    井口 光孝

    Medicina   Vol. 49 ( 11 ) page: 407 - 409   2012.11

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  19. P2-249 当院におけるセフェピム誘発性精神神経症状の発生状況(有害事象・副作用,ポスター,一般演題,岐路に立つ医療~千年紀の目覚め~よみがえれ!ニッポン!薬の改革は我らが手で!)

    加藤 善章, 井口 光孝, 山本 雅人, 八木 哲也, 山田 清文

    日本医療薬学会年会講演要旨集   Vol. 22 ( 0 ) page: 420 - 420   2012.10

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    DOI: 10.20825/amjsphcs.22.0_420_1

    CiNii Books

    CiNii Research

  20. 急性期病院における4ポイント簡易1次栄養スクリーニングの有用性について Reviewed

    中西 敏博, 武内 有城, 井口 光孝, 壁谷 めぐみ, 新木 智映子, 菊地 文, 梅村 聡美, 田所 史江, 国井 智子, 細川 真波

    静脈経腸栄養   Vol. 27 ( 4 ) page: 1079 - 1086   2012.7

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    【目的】当院では入院時簡易栄養スクリーニング(Nutritional Simple Screening on Admission;以下、NSSAと略)として、(1)標準体重比80%以下(2)褥瘡(3)経腸栄養も含めて食事摂取に問題(4)外見上栄養不良の4項目のうち1項目該当すれば栄養不良のリスクありとして栄養サポートチーム(Nutrition Support Team;以下、NSTと略)が介入している。今回、NSSAの精度を主観的包括的栄養評価(Subjective Global Assessment;以下、SGAと略)と比較した。【方法】内科系病棟において2ヵ月の全入院患者245例にNSSAとSGAをそれぞれ独立して行い、身体計測・血液検査も含めてNSSAが適切に栄養不良患者を抽出しているか検討した。【結果】NSSAによるNST介入要61例は、NST介入不要184例に比較して有意にSGAによる栄養不良の重症度が高く、%三頭筋皮下脂肪厚、%上腕筋囲および血清アルブミン値は介入要群で有意に低値であった。NSSAは、SGAで判定した栄養不良症例に対して、感度87.2%、特異度86.5%と良好であった。【結語】NSSAは適切に栄養不良患者を抽出しており、簡便さの点から臨床的に有用であると思われた。(著者抄録)

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J03242&link_issn=&doc_id=20120801120010&doc_link_id=10.11244%2Fjjspen.27.1079&url=https%3A%2F%2Fdoi.org%2F10.11244%2Fjjspen.27.1079&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  21. 【院内感染症に強くなる!発熱患者の診かたから、院内肺炎、手術部位感染など、よくある疾患別対応まで】【総論】感染症診療の基本 抗菌薬開始後の経過観察

    井口 光孝

    レジデントノート   Vol. 13 ( 5 ) page: 823 - 830   2011.7

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    (1)診断・治療の選択が論理的になされてはじめて、適切な『経過観察』が可能になる!(2)『経過観察』は1つのプランではない!(3)チェックすべきポイントを明確にして、1つずつアセスメントを行っていこう!(4)感染症の経過は「改善」か「悪化」かのどちらかで、「横ばい」はほとんどない!(5)『経過観察』には院内感染症の発症予防も含まれる!(著者抄録)

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J03286&link_issn=&doc_id=20110622020004&doc_link_id=%2Fai4resic%2F2011%2F001305%2F005%2F0823-0830%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fai4resic%2F2011%2F001305%2F005%2F0823-0830%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  22. 【高齢者救急診療】高齢者に多い内因性救急 感染症 総論的な観点から

    井口 光孝

    救急医学   Vol. 35 ( 6 ) page: 666 - 671   2011.6

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  23. 【困ったときのヒント満載 栄養力UP NST症例集(3)】非代償性肝硬変 消化管出血を繰り返す非代償性肝硬変患者に対して栄養サポートを含めた集学的治療が奏効した一例

    武内 有城, 井口 光孝, 園 真廉, 西岡 弘晶

    臨床栄養   Vol. 別冊 ( 栄養力UP NST症例集3 ) page: 32 - 38   2011.6

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    <栄養ケアのポイント>・非代償性肝硬変に合併する静脈瘤や消化性潰瘍も含めた難治性消化管出血への対応。・経口分岐鎖アミノ酸(Branched Chain Amino Acids、以下BCAA)製剤投与とLate Evening Snack(以下LES)の有用性。(著者抄録)

  24. 【ERで遭遇する一般市中感染症の診断と初期対応[前編]】ERで働くために知っておくべき情報 自施設の菌の感受性を把握していますか?

    井口 光孝, 八木 哲也

    ERマガジン   Vol. 8 ( 2 ) page: 214 - 217   2011.6

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  25. 【緊急画像トラブルシューティング 内科医のためのPearlとPitfall】感染症を疑ったら 感染症のフォーカス探し

    井口 光孝

    Medicina   Vol. 48 ( 4 ) page: 616 - 619   2011.4

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    <ポイント>★救急診療は感染症の宝庫.★感染症を診断する=感染している「微生物」と「臓器」を推定すること.★感染症診断の主役は病歴聴取・身体診察と微生物学的検査→画像検査はあくまで脇役.★事前(検査前)確率の見積もりのない画像検査は非常に危険.★感染症診断において画像検査が有用となる場合で,造影CTが最も有用であることが多い.(著者抄録)

  26. 【次に何をする? 呼吸ケアの「気付き力」を伸ばす危機対応クイズ】ウィーニング中・直後の急変を防ぐ「気付き力」

    武内 有城, 井口 光孝

    呼吸器ケア   Vol. 8 ( 6 ) page: 564 - 570   2010.6

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    <Key Point>人工呼吸管理の目的は、できる限り早く、そして問題なく自発呼吸に戻すことであり、そのためには人工呼吸管理の開始から常にウィーニングを考え、実践していくことが重要です。実際に、人工呼吸管理に費やす時間の41%はウィーニングともいわれており、急変などのリスク管理においても最も重要な過程といえます。今回は、ウィーニングにおける「人工呼吸器からの離脱」と「気管チューブの抜管」という局面において、急変を防ぐ「気付き力」について取り上げます。これらの状況では、患者の状態は変わりやすく、少しの油断が致命的な結果を招くこともあり、呼吸ケアスタッフの慎重できめ細やかな観察と対応が必須です。(著者抄録)

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J03901&link_issn=&doc_id=20100528240008&doc_link_id=%2Fao7kyuci%2F2010%2F000806%2F011%2F0564-0570%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fao7kyuci%2F2010%2F000806%2F011%2F0564-0570%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  27. 【Common Problem よくある疾患、見逃しやすい疾患】下痢

    園 真廉, 井口 光孝, 山中 克郎

    Modern Physician   Vol. 30 ( 6 ) page: 821 - 826   2010.6

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  28. 【デキる医師の紹介・逆紹介スキル99 「紹介する⇔紹介される」のギャップを埋める教訓集】感染症 紹介 感染症一般 紹介状作成とキノロン系抗菌薬について

    井口 光孝

    治療   Vol. 92 ( 4月増刊 ) page: 1104 - 1108   2010.4

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