Updated on 2023/12/08

写真a

 
KIM Hangsoo
 
Organization
Graduate School of Medicine Department of Renal Replacement Therapy Endowed Chair Designated lecturer
Title
Designated lecturer

Degree 1

  1. 博士（医学） （ 2014.4   名古屋大学 ） 

To the head of Degree.▲

Research History 1

  1. Nagoya University   Graduate School of Medicine Department of Renal Replacement Therapy Endowed Chair   Designated lecturer

    2023.4

To the head of Research History.▲
 

Papers 24

  1. Complement terminal pathway inhibition reduces peritoneal injuries in a rat peritonitis model Reviewed International journal

    Kamegai Naoki, Kim Hangsoo, Suzuki Yasuhiro, Fukui Sosuke, Kojima Hiroshi, Maruyama Shoichi, Morgan B. Paul, Zelek Wioleta Milena, Mizuno Masashi

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY     2023.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/cei/uxad088

    Web of Science

  2. Peritoneal Expression of Membrane Complement Regulators Is Decreased in Peritoneal Dialysis Patients with Infected Peritonitis Reviewed International journal

    Fukui Sosuke, Mizuno Masashi, Tawada Mitsuhiro, Suzuki Yasuhiro, Kojima Hiroshi, Matsukawa Yoshihisa, Imai Masaki, Kim Hangsoo, Kinashi Hiroshi, Mizutani Makoto, Minoshima Kenichi, Maruyama Shoichi, Ito Yasuhiko

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 24 ( 11 )   2023.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/ijms24119146

    Web of Science

  3. Serum and plasma levels of Ba, but not those of soluble C5b-9, might be affected by renal function in chronic kidney disease patients Reviewed International journal

    Yamane Ryoko, Yasuda Yoshinari, Oshima Aki, Suzuki Yasuhiro, Kojima Hiroshi, Kim Hangsoo, Fukui Sosuke, Maruyama Shoichi, Ito Yasuhiko, Mizuno Masashi

    BMC NEPHROLOGY   Vol. 24 ( 1 )   2023.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12882-022-03022-z

    Web of Science

  4. Long-term peritoneal dialysate exposure modulates expression of membrane complement regulators in human peritoneal mesothelial cells Reviewed International journal

    Kobayashi Kazuma, Ozeki Toshikazu, Kim Hangsoo, Imai Masaki, Kojima Hiroshi, Iguchi Daiki, Fukui Sosuke, Suzuki Masafumi, Suzuki Yasuhiro, Maruyama Shoichi, Ito Yasuhiko, Mizuno Masashi

    FRONTIERS IN MEDICINE   Vol. 9   2022.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fmed.2022.972592

    Web of Science

  5. Interleukin-6 blockade reduces salt-induced cardiac inflammation and fibrosis in subtotal nephrectomized mice Reviewed International journal

    Tanaka Hiroya, Sun Ting, Kinashi Hiroshi, Kamiya Keisuke, Yamaguchi Makoto, Nobata Hironobu, Sakata Fumiko, Kim Hangsoo, Mizuno Masashi, Kunoki Shunnosuke, Sakai Yukinao, Hirayama Akiyoshi, Soga Tomoyoshi, Yoshikawa Kazuhiro, Ishimoto Takuji, Ito Yasuhiko

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   Vol. 323 ( 6 ) page： F654 - F665   2022.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajprenal.00396.2021

    Web of Science

  6. Evidence of contribution by the classical but not Masp2 and lectin pathway of complement in a murine model of TMA caused by factor H mutation Reviewed International journal

    Golla, M; Gullipalli, D; Kim, H; Sato, S; Angampalli, S; Miwa, T; Song, WC

    MOLECULAR IMMUNOLOGY   Vol. 141   page： 174 - 174   2022.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Web of Science

  7. C1 inhibitor mitigates peritoneal injury in zymosan-induced peritonitis Reviewed International journal

    Ozeki Toshikazu, Mizuno Masashi, Iguchi Daiki, Kojima Hiroshi, Kim Hangsoo, Suzuki Yasuhiro, Kinashi Hiroshi, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   Vol. 320 ( 6 ) page： F1123 - F1132   2021.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajprenal.00600.2020

    Web of Science

  8. Refractory Hypotension Caused by Selenium Deficiency in a Patient on Peritoneal Dialysis International journal

    Ryuge Akihiro, Kim Hangsoo, Suzuki Yasuhiro, Okazaki Masaki, Kojima Hiroshi, Saito Shoji, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi, Mizuno Masashi

    Internal Medicine   Vol. 60 ( 15 ) page： 2461 - 2464   2021

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Society of Internal Medicine  

    <p>Selenium is essential for human health; its deficiency leads to cardiac dysfunction. We herein report a 79-year-old man on peritoneal dialysis who presented with refractory hypotension caused by selenium deficiency. He was admitted to our hospital with bacterial pneumonia and hypotension and abnormal electrocardiogram (ECG) findings. Despite improvement of pneumonia, his hypotension continued, and intravenous noradrenalin could not be discontinued. His serum selenium level was extremely low, and he was started on intravenous selenium. His hypotension and ECG findings gradually improved, and noradrenalin was discontinued. Physicians should consider selenium deficiency when patients on peritoneal dialysis show refractory hypotension. </p>

    DOI： 10.2169/internalmedicine.6632-20

    Web of Science

    PubMed

    CiNii Research

  9. Oral Antibiotics are Effective for Preventing Colonoscopy-associated Peritonitis as a Preemptive Therapy in Patients on Peritoneal Dialysis International journal

    Suzuki Yasuhiro, Mizuno Masashi, Kojima Hiroshi, Sato Yuka, Kim Hangsoo, Kinashi Hiroshi, Katsuno Takayuki, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko

    Internal Medicine   Vol. 60 ( 3 ) page： 353 - 356   2021

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Society of Internal Medicine  

    <p><b>Objective </b>In patients on peritoneal dialysis (PD), it was reported that colonoscopy, but not upper gastrointestinal endoscopy, could cause peritonitis as a complication. A guideline of the International Society for Peritoneal Dialysis recommends preemptive intravenous antibiotics administration of ampicillin and aminoglycoside with or without metronidazole, to prevent colonoscopy-associated peritonitis. In this study, we retrospectively evaluated the effects of preemptive antibiotics therapy by oral administration instead of intravenous administration. </p><p><b>Methods </b>We investigated the incidence of colonoscopy-associated peritonitis in a single center. In 170 patients undergoing PD between January 2010 and December 2019, 50 colonoscopies were performed, including 49 with oral administration of amoxicillin and ciprofloxacin and/or metronidazole as preemptive therapy 1 hour before the colonoscopy procedure, and 1 without. </p><p><b>Results </b>We observed no incidence of colonoscopy-associated peritonitis. </p><p><b>Conclusion </b>Generally, oral administration of preemptive antibiotics is less painful and more convenient than intravenous administration, especially in outpatient procedures, such as a colonoscopy. Our results suggest that oral antibiotic administration might be effective for preventing colonoscopy-associated peritonitis in PD patients. </p>

    DOI： 10.2169/internalmedicine.5092-20

    Web of Science

    PubMed

    CiNii Research

  10. ADENO-ASSOCIATED VIRUS (AAV)-MEDIATED FACTOR H GENE THERAPY IN A MURINE MODEL OF COMPLEMENT-DEPENDENT THROMBOTIC MICROANGIOPATHY AND SYSTEMIC THROMBOPHILIA Reviewed International journal

    Ito, D; Kim, H; Gullipalli, D; Miwa, T; Sato, S; Zhou, L; Palmer, M; Xie, J; Gao, GP; Song, WC

    MOLECULAR IMMUNOLOGY   Vol. 114   page： 462 - 463   2019.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Web of Science

  11. LEVEL OF ALTERNATIVE PATHWAY COMPLEMENT ACTIVITY DICTATES THROMBOTIC MICROANGIOPATHY PHENOTYPE IN FACTOR H W1206R MUTANT MICE Reviewed International journal

    Kim, H; Sato, S; Zhou, L; Ito, D; Miwa, T; Gullipalli, D; Fortuna, D; Palmer, M; Song, WC

    MOLECULAR IMMUNOLOGY   Vol. 114   page： 462 - 462   2019.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Web of Science

  12. Differential contribution of C5aR and C5b-9 pathways to renal thrombic microangiopathy and macrovascular thrombosis in mice carrying an atypical hemolytic syndrome-related factor H mutation. Reviewed International journal

    Ueda Y, Miwa T, Ito D, Kim H, Sato S, Gullipalli D, Zhou L, Golla M, Song D, Dunaief JL, Palmer MB, Song WC

    Kidney international   Vol. 96 ( 1 ) page： 67 - 79   2019.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.kint.2019.01.009

    PubMed

  13. Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice. Reviewed International journal

    Song D, Ueda Y, Bhuyan R, Mohammed I, Miwa T, Gullipali D, Kim H, Zhou L, Song Y, Schultz H, Bargoud A, Dunaief JL, Song WC

    The American journal of pathology   Vol. 189 ( 4 ) page： 826 - 838   2019.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ajpath.2019.01.009

    PubMed

  14. Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis Reviewed International journal

    Katsuno Takayuki, Ozaki Takenori, Ozeki Takaya, Hachiya Asaka, Kim Hangsoo, Kato Noritoshi, Ishimoto Takuji, Kato Sawako, Kosugi Tomoki, Tsuboi Naotake, Mizuno Masashi, Ito Yasuhiko, Maruyama Shoichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 22 ( 6 ) page： 1341 - 1350   2018.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10157-018-1590-2

    Web of Science

  15. C5aR and C5b-9 pathways drive different pathology in a murine model of aHUS and macrovascular thrombosis Reviewed International journal

    Ueda, Y; Miwa, T; Gullipalli, D; Sato, S; Zhou, L; Golla, M; Kim, H; Ito, D; Song, DL; Dunaief, J; Palmer, M; Song, WC

    MOLECULAR IMMUNOLOGY   Vol. 102   page： 223 - 223   2018.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.molimm.2018.06.234

    Web of Science

  16. Blocking Properdin Prevents Complement-Mediated Hemolytic Uremic Syndrome and Systemic Thrombophilia. Reviewed International journal

    Ueda Y, Miwa T, Gullipalli D, Sato S, Ito D, Kim H, Palmer M, Song WC

    Journal of the American Society of Nephrology : JASN   Vol. 29 ( 7 ) page： 1928 - 1937   2018.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1681/ASN.2017121244

    PubMed

  17. Single-dose Rituximab Therapy for Refractory Idiopathic Membranous Nephropathy: A Single-center Experience Reviewed International journal

    Katsuno Takayuki, Ozaki Takenori, Kim Hangsoo, Kato Noritoshi, Suzuki Yasuhiro, Akiyama Shinichi, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Ito Yasuhiko, Maruyama Shoichi

    INTERNAL MEDICINE   Vol. 56 ( 13 ) page： 1679 - 1686   2017

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2169/internalmedicine.56.7908

    Web of Science

  18. Transfusion of CD206<SUP>+</SUP> M2 Macrophages Ameliorates Antibody-Mediated Glomerulonephritis in Mice Reviewed International journal

    Du Qiuna, Tsuboi Naotake, Shi Yiqin, Ito Sachiko, Sugiyama Yutaka, Furuhashi Kazuhiro, Endo Nobuhide, Kim Hangsoo, Katsuno Takayuki, Akiyama Shin'ichi, Matsuo Seiichi, Isobe Ken-Ichi, Maruyama Shoichi

    AMERICAN JOURNAL OF PATHOLOGY   Vol. 186 ( 12 ) page： 3176 - 3188   2016.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ajpath.2016.08.012

    Web of Science

  19. Urinary soluble CD163 level reflects glomerular inflammation in human lupus nephritis Reviewed International journal

    Endo Nobuhide, Tsuboi Naotake, Furuhashi Kazuhiro, Shi Yiqin, Du Qiuna, Abe Tomoko, Hori Mayuko, Imaizumi Takahiro, Kim Hangsoo, Katsuno Takayuki, Ozaki Takenori, Kosugi Tomoki, Matsuo Seiichi, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 31 ( 12 ) page： 2023 - 2033   2016.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/ndt/gfw214

    Web of Science

  20. Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury Reviewed International journal

    Hattori Yuka, Kim Hangsoo, Tsuboi Naotake, Yamamoto Akihito, Akiyama Shinichi, Shi Yiqin, Katsuno Takayuki, Kosugi Tomoki, Ueda Minoru, Matsuo Seiichi, Maruyama Shoichi

    PLOS ONE   Vol. 10 ( 10 )   2015.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0140121

    Web of Science

  21. Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation Reviewed International journal

    Kim Hangsoo, Mizuno Masashi, Furuhashi Kazuhiro, Katsuno Takayuki, Ozaki Takenori, Yasuda Kaoru, Tsuboi Naotake, Sato Waichi, Suzuki Yasuhiro, Matsuo Seiichi, Ito Yasuhiko, Maruyama Shoichi

    CYTOTHERAPY   Vol. 16 ( 3 ) page： 357 - 368   2014.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jcyt.2013.10.011

    Web of Science

    PubMed

  22. Serum-Starved Adipose-Derived Stromal Cells Ameliorate Crescentic GN by Promoting Immunoregulatory Macrophages Reviewed International journal

    Furuhashi Kazuhiro, Tsuboi Naotake, Shimizu Asuka, Katsuno Takayuki, Kim Hangsoo, Saka Yosuke, Ozaki Takenori, Sado Yoshikazu, Imai Enyu, Matsuo Seiichi, Maruyama Shoichi

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   Vol. 24 ( 4 ) page： 587 - 603   2013.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1681/ASN.2012030264

    Web of Science

  23. Low Serum Cultured Adipose Tissue-Derived Stromal Cells Ameliorate Acute Kidney Injury in Rats Reviewed International journal

    Katsuno Takayuki, Ozaki Takenori, Saka Yosuke, Furuhashi Kazuhiro, Kim Hangsoo, Yasuda Kaoru, Yamamoto Tokunori, Sato Waichi, Tsuboi Naotake, Mizuno Masashi, Ito Yasuhiko, Imai Enyu, Matsuo Seiichi, Maruyama Shoichi

    CELL TRANSPLANTATION   Vol. 22 ( 2 ) page： 287 - 297   2013

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3727/096368912X655019

    Web of Science

  24. Adipose-derived stromal cells cultured in a low-serum medium, but not bone marrow-derived stromal cells, impede xenoantibody production Reviewed International journal

    Saka Yosuke, Furuhashi Kazuhiro, Katsuno Takayuki, Kim Hangsoo, Ozaki Takenori, Iwasaki Kenta, Haneda Masataka, Sato Waichi, Tsuboi Naotake, Ito Yasuhiko, Matsuo Seiichi, Kobayashi Takaaki, Maruyama Shoichi

    XENOTRANSPLANTATION   Vol. 18 ( 3 ) page： 196 - 208   2011

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1399-3089.2011.00640.x

    Web of Science

▼display all

To the head of Papers.▲

MISC 2

  1. 特集 Genetics in CKD 疾患編 補体関連遺伝子の異常と腎疾患

    金 恒秀, 水野 正司

    腎と透析   Vol. 94 ( 3 ) page： 405 - 410   2023.3

    　More details

    Publisher：東京医学社  

    DOI： 10.24479/kd.0000000656

    CiNii Research

  2. 植込み型補助人工心臓入れ替え術後に偽性高クレアチニン血症を来した一例

    安田 宜成, 金 恒秀, 石川 裕介, 斎藤 尚二, 加藤 規利, 小杉 智規, 六鹿 雅登, 丸山 彰一

    移植   Vol. 57 ( Supplement ) page： s335_3 - s335_3   2022

    　More details

    Language：Japanese   Publisher：一般社団法人 日本移植学会  

    <p>症例は50歳代男性。Xー12年に心不全のためA病院入院。心筋生検にて拡張型心筋症と診断。その後入退院を繰り返し、心臓移植申請を目的にX－5年7月に名大病院紹介となった。心臓移植適応判定を得て、同年10月に植込み型補助人工心臓（HM-II)植え込み術施行。X年3月24日にドライブラインの断線疑いでHM-IIIへ入れ替え術施行。術後に尿路感染合併し4月2日より抗菌薬治療開始したところ、sCr（mg/dL）0.79-0.96から2.49へと悪化し、その後も改善しないため、4月4日腎臓内科紹介された。CTでは左胸水少量認め、IVC虚脱や水腎症を認めず、腎機能障害の原因は不明であった。ARB中止して経過観察したが4月8日sCr3.02と腎機能は改善せず，別の腎機能検査であるsCysC(mg/L)は0.91と著しい乖離を認めた。4月18日イヌリンクリアランス検査を行い実測GFR84.2（ｍL/分/1.73m2）、sCr.2.59，sCysC0.85、eGFRcreat21.3，eGFRcys88.8であり、偽性高Cr血症が疑われた。そこで酵素法（シグナスオートCRE）とHPLC法でsCrを比較したところ2.4と0.8であった。酵素法のR-Ⅱ試薬添加後に副波長の吸光度が上昇し続けており、血清に含めれる蛋白成分による混濁が疑われた。その後はsCrは希釈無し、2倍、4倍希釈で評価しており、各々3.23～4.69，0.76～1.14、0.76～0.96であった。心臓移植待機者において偽性高Cr血症を経験したため文献的考察を含め報告する。</p>

    DOI： 10.11386/jst.57.supplement_s335_3

    CiNii Research

To the head of MISC.▲

Presentations 1

  1. MASP3 deficiency ameliorates but does not completely prevent alternative pathway complement-mediated tissue injury in a factor H mutant mouse model

    Kim Hangsoo, Gullipalli Damodar, Miwa Takashi, Sato Sayaka, Golla Madhu, Palmer Matthew, Song Wen-Chao

    IMMUNOBIOLOGY  2023.9 

    　More details

To the head of Presentations.▲

KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. Analysis of pathogenesis associated with mutation of complement associated gene and autoantibodies in development/progression of C3 nephropathy.

    Grant number：22K08309  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Authorship：Coinvestigator(s) 

  2. ループス腎炎における補体副経路の役割解明と治療への応用

    Grant number：21K08274  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    金 恒秀, 水野 正司, 鈴木 康弘, 石本 卓嗣, 福井 聡介

    　 More details

    Authorship：Principal investigator 

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    ループス腎炎は全身性エリテマトーデスに伴う主要な臓器障害で、近年の免疫抑制療法によっても未だ多数の患者が末期腎不全に陥っている。自然免疫の一部である補体はループス腎炎の病態に深く関わっており、新たな治療標的になると期待されている。本研究では、ループス腎炎における補体（副経路）の病態への関わりを、活性系の抑制および制御系の増強の二つのアプローチで解明し、新たな治療法の提示を行う。

  3. Elucidation of the mechanism of peritoneal dialysis-related peritoneal injury through complement pathway and establishment of novel anti-complement therapy.

    Grant number：21K08275  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Authorship：Coinvestigator(s) 

To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲