Organization
Graduate School of Medicine Department of Renal Replacement Therapy Endowed Chair Designated lecturer
Title
Designated lecturer
KIM Hangsoo
Degree 1
-
博士（医学） （ 2014.4 名古屋大学 ）
Research History 1
-
Nagoya University Graduate School of Medicine Department of Renal Replacement Therapy Endowed Chair Designated lecturer
2023.4
Papers 27
-
Pathophysiological Mechanisms of Peritoneal Fibrosis and Peritoneal Membrane Dysfunction in Peritoneal Dialysis. Reviewed International journal
Ito Y, Sun T, Tawada M, Kinashi H, Yamaguchi M, Katsuno T, Kim H, Mizuno M, Ishimoto T
International journal of molecular sciences Vol. 25 ( 16 ) 2024.8
-
Durvalumab plus carboplatin-etoposide treatment in a patient with small-cell lung cancer on hemodialysis: a case report and literature review. Reviewed International journal
Ushijima F, Hase T, Yamashita Y, Kim H, Shimokata T, Kondo C, Sato T, Baba T, Watanabe S, Futamura K, Ando Y, Mizuno M, Ishii M
International cancer conference journal Vol. 13 ( 2 ) page： 88 - 92 2024.4
-
今月の特集2 補体をめぐる話題 注目の補体異常症 C3腎症 Reviewed International journal
金 恒秀, 水野 正司
臨床検査 Vol. 68 ( 1 ) page： 88 - 92 2024.1
-
Complement terminal pathway inhibition reduces peritoneal injuries in a rat peritonitis model Reviewed International journal
Kamegai Naoki, Kim Hangsoo, Suzuki Yasuhiro, Fukui Sosuke, Kojima Hiroshi, Maruyama Shoichi, Morgan B. Paul, Zelek Wioleta Milena, Mizuno Masashi
CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2023.8
-
Peritoneal Expression of Membrane Complement Regulators Is Decreased in Peritoneal Dialysis Patients with Infected Peritonitis Reviewed International journal
Fukui Sosuke, Mizuno Masashi, Tawada Mitsuhiro, Suzuki Yasuhiro, Kojima Hiroshi, Matsukawa Yoshihisa, Imai Masaki, Kim Hangsoo, Kinashi Hiroshi, Mizutani Makoto, Minoshima Kenichi, Maruyama Shoichi, Ito Yasuhiko
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 24 ( 11 ) 2023.5
-
Serum and plasma levels of Ba, but not those of soluble C5b-9, might be affected by renal function in chronic kidney disease patients Reviewed International journal
Yamane Ryoko, Yasuda Yoshinari, Oshima Aki, Suzuki Yasuhiro, Kojima Hiroshi, Kim Hangsoo, Fukui Sosuke, Maruyama Shoichi, Ito Yasuhiko, Mizuno Masashi
BMC NEPHROLOGY Vol. 24 ( 1 ) 2023.2
-
Long-term peritoneal dialysate exposure modulates expression of membrane complement regulators in human peritoneal mesothelial cells Reviewed International journal
Kobayashi Kazuma, Ozeki Toshikazu, Kim Hangsoo, Imai Masaki, Kojima Hiroshi, Iguchi Daiki, Fukui Sosuke, Suzuki Masafumi, Suzuki Yasuhiro, Maruyama Shoichi, Ito Yasuhiko, Mizuno Masashi
FRONTIERS IN MEDICINE Vol. 9 2022.12
-
Interleukin-6 blockade reduces salt-induced cardiac inflammation and fibrosis in subtotal nephrectomized mice Reviewed International journal
Tanaka Hiroya, Sun Ting, Kinashi Hiroshi, Kamiya Keisuke, Yamaguchi Makoto, Nobata Hironobu, Sakata Fumiko, Kim Hangsoo, Mizuno Masashi, Kunoki Shunnosuke, Sakai Yukinao, Hirayama Akiyoshi, Soga Tomoyoshi, Yoshikawa Kazuhiro, Ishimoto Takuji, Ito Yasuhiko
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY Vol. 323 ( 6 ) page： F654 - F665 2022.12
-
Evidence of contribution by the classical but not Masp2 and lectin pathway of complement in a murine model of TMA caused by factor H mutation Reviewed International journal
Golla, M; Gullipalli, D; Kim, H; Sato, S; Angampalli, S; Miwa, T; Song, WC
MOLECULAR IMMUNOLOGY Vol. 141 page： 174 - 174 2022.1
-
C1 inhibitor mitigates peritoneal injury in zymosan-induced peritonitis Reviewed International journal
Ozeki Toshikazu, Mizuno Masashi, Iguchi Daiki, Kojima Hiroshi, Kim Hangsoo, Suzuki Yasuhiro, Kinashi Hiroshi, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY Vol. 320 ( 6 ) page： F1123 - F1132 2021.6
-
Refractory Hypotension Caused by Selenium Deficiency in a Patient on Peritoneal Dialysis International journal
Ryuge Akihiro, Kim Hangsoo, Suzuki Yasuhiro, Okazaki Masaki, Kojima Hiroshi, Saito Shoji, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi, Mizuno Masashi
Internal Medicine Vol. 60 ( 15 ) page： 2461 - 2464 2021
-
Oral Antibiotics are Effective for Preventing Colonoscopy-associated Peritonitis as a Preemptive Therapy in Patients on Peritoneal Dialysis International journal
Suzuki Yasuhiro, Mizuno Masashi, Kojima Hiroshi, Sato Yuka, Kim Hangsoo, Kinashi Hiroshi, Katsuno Takayuki, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko
Internal Medicine Vol. 60 ( 3 ) page： 353 - 356 2021
-
ADENO-ASSOCIATED VIRUS (AAV)-MEDIATED FACTOR H GENE THERAPY IN A MURINE MODEL OF COMPLEMENT-DEPENDENT THROMBOTIC MICROANGIOPATHY AND SYSTEMIC THROMBOPHILIA Reviewed International journal
Ito, D; Kim, H; Gullipalli, D; Miwa, T; Sato, S; Zhou, L; Palmer, M; Xie, J; Gao, GP; Song, WC
MOLECULAR IMMUNOLOGY Vol. 114 page： 462 - 463 2019.10
-
LEVEL OF ALTERNATIVE PATHWAY COMPLEMENT ACTIVITY DICTATES THROMBOTIC MICROANGIOPATHY PHENOTYPE IN FACTOR H W1206R MUTANT MICE Reviewed International journal
Kim, H; Sato, S; Zhou, L; Ito, D; Miwa, T; Gullipalli, D; Fortuna, D; Palmer, M; Song, WC
MOLECULAR IMMUNOLOGY Vol. 114 page： 462 - 462 2019.10
-
Differential contribution of C5aR and C5b-9 pathways to renal thrombic microangiopathy and macrovascular thrombosis in mice carrying an atypical hemolytic syndrome-related factor H mutation. Reviewed International journal
Ueda Y, Miwa T, Ito D, Kim H, Sato S, Gullipalli D, Zhou L, Golla M, Song D, Dunaief JL, Palmer MB, Song WC
Kidney international Vol. 96 ( 1 ) page： 67 - 79 2019.7
-
Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice. Reviewed International journal
Song D, Ueda Y, Bhuyan R, Mohammed I, Miwa T, Gullipali D, Kim H, Zhou L, Song Y, Schultz H, Bargoud A, Dunaief JL, Song WC
The American journal of pathology Vol. 189 ( 4 ) page： 826 - 838 2019.4
-
Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis Reviewed International journal
Katsuno Takayuki, Ozaki Takenori, Ozeki Takaya, Hachiya Asaka, Kim Hangsoo, Kato Noritoshi, Ishimoto Takuji, Kato Sawako, Kosugi Tomoki, Tsuboi Naotake, Mizuno Masashi, Ito Yasuhiko, Maruyama Shoichi
CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 22 ( 6 ) page： 1341 - 1350 2018.12
-
C5aR and C5b-9 pathways drive different pathology in a murine model of aHUS and macrovascular thrombosis Reviewed International journal
Ueda, Y; Miwa, T; Gullipalli, D; Sato, S; Zhou, L; Golla, M; Kim, H; Ito, D; Song, DL; Dunaief, J; Palmer, M; Song, WC
MOLECULAR IMMUNOLOGY Vol. 102 page： 223 - 223 2018.10
-
Blocking Properdin Prevents Complement-Mediated Hemolytic Uremic Syndrome and Systemic Thrombophilia. Reviewed International journal
Ueda Y, Miwa T, Gullipalli D, Sato S, Ito D, Kim H, Palmer M, Song WC
Journal of the American Society of Nephrology : JASN Vol. 29 ( 7 ) page： 1928 - 1937 2018.7
-
Single-dose Rituximab Therapy for Refractory Idiopathic Membranous Nephropathy: A Single-center Experience Reviewed International journal
Katsuno Takayuki, Ozaki Takenori, Kim Hangsoo, Kato Noritoshi, Suzuki Yasuhiro, Akiyama Shinichi, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Ito Yasuhiko, Maruyama Shoichi
INTERNAL MEDICINE Vol. 56 ( 13 ) page： 1679 - 1686 2017
-
Transfusion of CD206<SUP>+</SUP> M2 Macrophages Ameliorates Antibody-Mediated Glomerulonephritis in Mice Reviewed International journal
Du Qiuna, Tsuboi Naotake, Shi Yiqin, Ito Sachiko, Sugiyama Yutaka, Furuhashi Kazuhiro, Endo Nobuhide, Kim Hangsoo, Katsuno Takayuki, Akiyama Shin'ichi, Matsuo Seiichi, Isobe Ken-Ichi, Maruyama Shoichi
AMERICAN JOURNAL OF PATHOLOGY Vol. 186 ( 12 ) page： 3176 - 3188 2016.12
-
Urinary soluble CD163 level reflects glomerular inflammation in human lupus nephritis Reviewed International journal
Endo Nobuhide, Tsuboi Naotake, Furuhashi Kazuhiro, Shi Yiqin, Du Qiuna, Abe Tomoko, Hori Mayuko, Imaizumi Takahiro, Kim Hangsoo, Katsuno Takayuki, Ozaki Takenori, Kosugi Tomoki, Matsuo Seiichi, Maruyama Shoichi
NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 31 ( 12 ) page： 2023 - 2033 2016.12
-
Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury Reviewed International journal
Hattori Yuka, Kim Hangsoo, Tsuboi Naotake, Yamamoto Akihito, Akiyama Shinichi, Shi Yiqin, Katsuno Takayuki, Kosugi Tomoki, Ueda Minoru, Matsuo Seiichi, Maruyama Shoichi
PLOS ONE Vol. 10 ( 10 ) 2015.10
-
Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation Reviewed International journal
Kim Hangsoo, Mizuno Masashi, Furuhashi Kazuhiro, Katsuno Takayuki, Ozaki Takenori, Yasuda Kaoru, Tsuboi Naotake, Sato Waichi, Suzuki Yasuhiro, Matsuo Seiichi, Ito Yasuhiko, Maruyama Shoichi
CYTOTHERAPY Vol. 16 ( 3 ) page： 357 - 368 2014.3
-
Serum-Starved Adipose-Derived Stromal Cells Ameliorate Crescentic GN by Promoting Immunoregulatory Macrophages Reviewed International journal
Furuhashi Kazuhiro, Tsuboi Naotake, Shimizu Asuka, Katsuno Takayuki, Kim Hangsoo, Saka Yosuke, Ozaki Takenori, Sado Yoshikazu, Imai Enyu, Matsuo Seiichi, Maruyama Shoichi
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Vol. 24 ( 4 ) page： 587 - 603 2013.4
-
Low Serum Cultured Adipose Tissue-Derived Stromal Cells Ameliorate Acute Kidney Injury in Rats Reviewed International journal
Katsuno Takayuki, Ozaki Takenori, Saka Yosuke, Furuhashi Kazuhiro, Kim Hangsoo, Yasuda Kaoru, Yamamoto Tokunori, Sato Waichi, Tsuboi Naotake, Mizuno Masashi, Ito Yasuhiko, Imai Enyu, Matsuo Seiichi, Maruyama Shoichi
CELL TRANSPLANTATION Vol. 22 ( 2 ) page： 287 - 297 2013
-
Adipose-derived stromal cells cultured in a low-serum medium, but not bone marrow-derived stromal cells, impede xenoantibody production Reviewed International journal
Saka Yosuke, Furuhashi Kazuhiro, Katsuno Takayuki, Kim Hangsoo, Ozaki Takenori, Iwasaki Kenta, Haneda Masataka, Sato Waichi, Tsuboi Naotake, Ito Yasuhiko, Matsuo Seiichi, Kobayashi Takaaki, Maruyama Shoichi
XENOTRANSPLANTATION Vol. 18 ( 3 ) page： 196 - 208 2011
MISC 2
-
特集 Genetics in CKD 疾患編 補体関連遺伝子の異常と腎疾患
金 恒秀, 水野 正司
腎と透析 Vol. 94 ( 3 ) page： 405 - 410 2023.3
-
植込み型補助人工心臓入れ替え術後に偽性高クレアチニン血症を来した一例
安田 宜成, 金 恒秀, 石川 裕介, 斎藤 尚二, 加藤 規利, 小杉 智規, 六鹿 雅登, 丸山 彰一
移植 Vol. 57 ( Supplement ) page： s335_3 - s335_3 2022
Presentations 1
-
MASP3 deficiency ameliorates but does not completely prevent alternative pathway complement-mediated tissue injury in a factor H mutant mouse model
Kim Hangsoo, Gullipalli Damodar, Miwa Takashi, Sato Sayaka, Golla Madhu, Palmer Matthew, Song Wen-Chao
IMMUNOBIOLOGY 2023.9
KAKENHI (Grants-in-Aid for Scientific Research) 4
-
補体H因子遺伝子改変マウスを用いた組織局所産生・細胞内補体の機能解明と治療応用
Grant number：24K11408 2024.4 - 2027.3
科学研究費助成事業 基盤研究(C)
金 恒秀, 水野 正司, 福井 聡介
Authorship：Principal investigator
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
補体と様々な疾患の関わりが明らかになり、抗補体薬による治療により希少難治性疾患の予後が大きく改善してきたが、病態における補体の機能解明は不十分である。本研究では、２系統の補体H因子遺伝子改変マウスの①各臓器・組織局所での補体産生、②ネフロンを構成する細胞の細胞内補体を網羅的に解析しその機能を明らかにすることで、病態のより深い理解を進める。
-
Grant number：22K08309 2022.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Coinvestigator(s)
-
Grant number：21K08275 2021.4 - 2024.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Coinvestigator(s)
-
Grant number：21K08274 2021.4 - 2024.3
科学研究費助成事業 基盤研究(C)
金 恒秀, 水野 正司, 鈴木 康弘, 石本 卓嗣, 福井 聡介
Authorship：Principal investigator
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
ループス腎炎は全身性エリテマトーデスに伴う主要な臓器障害で、近年の免疫抑制療法によっても未だ多数の患者が末期腎不全に陥っている。自然免疫の一部である補体はループス腎炎の病態に深く関わっており、新たな治療標的になると期待されている。本研究では、ループス腎炎における補体（副経路）の病態への関わりを、活性系の抑制および制御系の増強の二つのアプローチで解明し、新たな治療法の提示を行う。