Updated on 2022/12/06

写真a

 
KIDOKORO Hiroyuki
 
Organization
Nagoya University Hospital Pediatrics Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 1

  1. Doctor(Medicine) ( 2010.3   Nagoya University ) 

Research Interests 4

  1. Neuroscience

  2. Neonatal Neurology

  3. Pediatric Neurology

  4. CaMK

Research Areas 2

  1. Life Science / Neuroscience-general

  2. Life Science / Embryonic medicine and pediatrics  / 小児神経学

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2010.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1992.4 - 1998.3

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    Country: Japan

Professional Memberships 7

  1. 日本小児科学会

  2. 日本小児神経学会   評議員

  3. 日本てんかん学会

  4. 日本周産期新生児医学会

  5. 日本新生児成育医学会

  6. 日本神経科学会

  7. Infantile Seizure Society

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Committee Memberships 1

  1. 日本小児神経学会   教育委員会  

    2022.1   

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    Committee type:Academic society

    教育委員長

 

Papers 52

  1. Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study. International journal

    Takafumi Ushida, Hiroyuki Kidokoro, Noriyuki Nakamura, Satoru Katsuki, Kenji Imai, Tomoko Nakano-Kobayashi, Yoshinori Moriyama, Yoshiaki Sato, Masahiro Hayakawa, Jun Natsume, Hiroaki Kajiyama, Tomomi Kotani

    Pregnancy hypertension   Vol. 25   page: 143 - 149   2021.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: Infants born to mothers with hypertensive disorders of pregnancy (HDP) reportedly have negative behavioral and neurodevelopmental outcomes. However, the effects of maternal HDP on infant brain growth have not been fully evaluated. We aimed to evaluate brain volumes and brain injury in preterm infants born to mothers with HDP using magnetic resonance (MR) imaging at term-equivalent age. STUDY DESIGN: In this cohort study, MR imaging was performed for 94 preterm infants born before 34 weeks of gestation at Nagoya University Hospital between 2010 and 2018. Twenty infants were born to mothers with HDP and 74 to mothers without HDP. MAIN OUTCOME MEASURES: Total brain volumes and regional volumetric alterations were assessed by voxel-based morphometry, and brain injury was evaluated using the Kidokoro global brain abnormality score. Developmental quotient was assessed at a corrected age of 1.5 years in 59 infants (HDP, n = 11; non-HDP, n = 48). RESULTS: No significant differences were observed in the gray and white matter volumes of the two groups (HDP: 175 ± 24 mL, 137 ± 13 mL, respectively; non-HDP: 172 ± 24 mL, 142 ± 13 mL, respectively). Additionally, no regional volumetric alterations were observed between the two groups after covariate adjustment (gestational age and infant sex). The total Kidokoro score and developmental quotient were similar in both groups. CONCLUSIONS: No significant differences in the global and regional brain volumes were observed. Further research is needed to confirm our findings at different time points of MR imaging and in different populations.

    DOI: 10.1016/j.preghy.2021.06.003

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  2. Age estimates from brain magnetic resonance images of children younger than two years of age using deep learning. International journal

    Masahiro Kawaguchi, Hiroyuki Kidokoro, Rintaro Ito, Anna Shiraki, Takeshi Suzuki, Yuki Maki, Masaharu Tanaka, Yoko Sakaguchi, Hiroyuki Yamamoto, Yosiyuki Takahashi, Shinji Naganawa, Jun Natsume

    Magnetic resonance imaging   Vol. 79   page: 38 - 44   2021.6

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    The accuracy of brain age estimates from magnetic resonance (MR) images has improved with the advent of deep learning artificial intelligence (AI) models. However, most previous studies on predicting age emphasized aging from childhood to adulthood and old age, and few studies have focused on early brain development in children younger than 2 years of age. Here, we performed brain age estimates based on MR images in children younger than 2 years of age using deep learning. Our AI model, developed with one slice each of raw T1- and T2-weighted images from each subject, estimated brain age with a mean absolute error of 8.2 weeks (1.9 months). The estimates of our AI model were close to those of human specialists. The AI model also estimated the brain age of subjects with a myelination delay as significantly younger than the chronological age. These results indicate that the prediction accuracy of our AI model approached that of human specialists and that our simple method requiring less data and preprocessing facilitates a radiological assessment of brain development, such as monitoring maturational changes in myelination.

    DOI: 10.1016/j.mri.2021.03.004

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  3. Delta Brushes Are Not Just a Hallmark of EEG in Human Preterm Infants. Reviewed International journal

    Hiroyuki Kidokoro

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 63 ( 2 ) page: 130 - 136   2021.2

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Delta brush, a well-known characteristic waveform of the human preterm electroencephalogram, represents spontaneous electrical activity. Recent experimental animal model evidence suggests that delta brushes are not only spontaneous intrinsic activity but are also evoked by external sensory stimulation or spontaneous movement. Additionally, delta brushes are likely to reflect the activity of subplate neurons, which also play an important role in early brain development and network organization. Here, evidence about delta brush in human preterm electroencephalogram is provided along with future perspectives.

    File: ped.14420.pdf

    DOI: 10.1111/ped.14420

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  4. Acute Necrotizing Encephalopathy: A Disease Meriting Greater Recognition

    Hiroyuki Kidokoro

    American Journal of Neuroradiology   Vol. 41 ( 12 ) page: 2255 - 2256   2020.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    File: ajnr.A6821.full.pdf

    DOI: 10.3174/ajnr.A6821

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  5. Effect of spontaneous electrical activity on the developing cortex. Invited Reviewed International journal

    Hiroyuki Kidokoro

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 62 ( 10 ) page: 1131 - 1132   2020.10

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    File: ped.14407.pdf

    DOI: 10.1111/ped.14407

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  6. High-amplitude fast activity in EEG: An early diagnostic marker in children with beta-propeller protein-associated neurodegeneration (BPAN) Reviewed

    Hiroyuki Kidokoro, Hiroyuki Yamamoto, Tetsuo Kubota, Mitsuo Motobayashi, Yusaku Miyamoto, Tomohiko Nakata, Kyoko Takano, Naoko Shiba, Yu Okai, Masaharu Tanaka, Yoko Sakaguchi, Yuki Maki, Masahiro Kawaguchi, Takeshi Suzuki, Kazuhiro Muramatsu, Jun Natsume

    Clinical Neurophysiology   Vol. 131 ( 9 ) page: 2100 - 2104   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    File: 1-s2.0-S1388245720303710-main.pdf

    DOI: 10.1016/j.clinph.2020.06.006

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  7. Gait performance and dual-task costs in school-aged children with Down syndrome.

    Ito Y, Ito T, Ohno A, Kubota T, Tanemura K, Narahara S, Kataoka E, Hyodo R, Sugiyama Y, Hattori T, Kidokoro H, Sugiura H, Noritake K, Natsume J, Ochi N

    Brain & development     2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.braindev.2022.11.001

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  8. Impact of the Coronavirus Disease 2019 Pandemic on the Clinical Features of Pediatric Respiratory Syncytial Virus Infection in Japan.

    Ozeki S, Kawada JI, Yamashita D, Yasufuku C, Akano T, Kato M, Suzuki K, Tano C, Matsumoto K, Mizutani SH, Mori A, Nishio N, Kidokoro H, Yasui Y, Takahashi Y, Sato Y, Nagoya Collaborative Clinical Research Team

    Open forum infectious diseases   Vol. 9 ( 11 ) page: ofac562   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ofid/ofac562

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  9. Forster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKII alpha activity in de novo mutations related to intellectual disability

    Fujii Hajime, Kidokoro Hiroyuki, Kondo Yayoi, Kawaguchi Masahiro, Horigane Shin-ichiro, Natsume Jun, Takemoto-Kimura Sayaka, Bito Haruhiko

    FRONTIERS IN MOLECULAR NEUROSCIENCE   Vol. 15   page: 970031   2022.9

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    DOI: 10.3389/fnmol.2022.970031

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  10. Quantitative Three-Dimensional Gait Evaluation in Patients With Glucose Transporter 1 Deficiency Syndrome.

    Suzuki T, Ito Y, Ito T, Kidokoro H, Noritake K, Hattori A, Nabatame S, Natsume J

    Pediatric neurology   Vol. 132   page: 23 - 26   2022.4

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    DOI: 10.1016/j.pediatrneurol.2022.04.012

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  11. Acute encephalopathy with biphasic seizures and late reduced diffusion: Predictive EEG findings. International journal

    Atsuko Ohno, Akihisa Okumura, Tatsuya Fukasawa, Tomohiko Nakata, Motomasa Suzuki, Masaharu Tanaka, Yu Okaia, Yuji Ito, Hiroyuki Yamamoto, Takeshi Tsuji, Hiroyuki Kidokoro, Shinji Saitoh, Jun Natsume

    Brain & development   Vol. 44 ( 3 ) page: 221 - 228   2022.3

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    BACKGROUND: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a common type of acute encephalopathy in Japan; the condition is clinically characterized by prolonged seizures as the initial neurological symptom, followed by late seizures 4-6 days later. It is difficult to differentiate AESD from prolonged febrile seizures (PFSs). Here, we explored the use of electroencephalography to differentiate AESD from PFSs. METHODS: We studied the electroencephalograms (EEGs) of children <6 years of age diagnosed with AESD or PFSs; all EEGs were recorded within 48 h of seizure onset (i.e., before the late seizures of AESD). Two pediatric neurologists evaluated all EEGs, focusing on the basic rhythm, slowing during wakefulness/arousal by stimuli, spindles, fast waves, and slowing during sleep. RESULTS: The EEGs of 14 children with AESD and 31 children with PFSs were evaluated. Spindles were more commonly reduced or absent in children with AESD than in those with PFSs (71% vs. 31%, p = 0.021). Fast waves were also more commonly reduced or absent in children with AESD (21% vs. 0%, p = 0.030). The rates of all types of slowing did not differ between children with AESD and those with PFSs, but continuous or frequent slowing during sleep was more common in the former (50% vs. 17%, p = 0.035). CONCLUSIONS: EEG findings may usefully differentiate AESD from PFSs. Reduced or absent spindles/fast waves and continuous or frequent slowing during sleep are suggestive of AESD in children with prolonged seizures associated with fever.

    DOI: 10.1016/j.braindev.2021.11.003

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  12. Involvement of brain structures in childhood epilepsy with centrotemporal spikes

    Ito Yuji, Maki Yuki, Okai Yu, Kidokoro Hiroyuki, Bagarinao Epifanio, Takeuchi Tomoya, Ohno Atsuko, Nakata Tomohiko, Ishihara Naoko, Okumura Akihisa, Yamamoto Hiroyuki, Maesawa Satoshi, Natsume Jun

    PEDIATRICS INTERNATIONAL   Vol. 64 ( 1 ) page: e15001   2022.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ped.15001

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  13. Proceedings of the 13th International Newborn Brain Conference: Fetal and/or neonatal brain development, both normal and abnormal.

    Abdi K, Abramsky R, Andescavage N, Bambi J, Basu S, Bearer C, Benner EJ, Biselele T, Bliznyuk N, Breckpot J, Carey G, Chao A, Christiansen LI, Comani S, Croce P, De Vos M, Dereymaeker A, Dubois L, Eisch AJ, Epstein A, Geva N, Geva Y, Gewillig M, Gillis S, Goldberg RN, Gram M, Gregory S, Guez-Barber D, Hayakawa M, Henriksen NL, Hermans T, Hershkovitz R, Holgersen K, Holmqvist B, Jain V, Jansen K, Kandula V, Kapse K, Kawaguchi M, Khair A, Khazaei M, Kidokoro H, Kiffer FC, Kisilewicz K, Kumai S, Lacaille H, Ley D, Limperopoulos C, Lindholm SEH, Lukusa P, Lundberg R, MacFarlane P, Matak P, Mavinga L, Mayer C, Mbayabo G, Mitsumatsu T, Mubungu G, Murnick J, Nakata T, Narita H, Nataraj P, Natsume J, Naulaers G, Nikam R, Ortenlöf N, Ottolini K, Pan X, Pankratova S, Pegram K, Penn AA, Pradhan S, Raeisi K, Rickman N, Rikard B, Rotem R, Sangild PT, Sato Y, Sawamura F, Shany E, Shelef I, Shiraki A, Smets L, Sura L, Suzui R, Suzuki T, Tady BP, Taga G, Tamburro G, Thewissen L, Thompson JW, Thymann T, Tokat C, Vacher CM, Valdes C, Vallius S, Vatolin S, Watanabe H, Weintraub AY, Weiss M, Yamamoto H, Yaniv SS, Younge N, Yun S, Zappasodi F

    Journal of neonatal-perinatal medicine   Vol. 15 ( 2 ) page: 411 - 426   2022

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    DOI: 10.3233/NPM-229002

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  14. Effectiveness of lacosamide in children and young adults previously treated with other sodium channel blockers

    Suzuki Takeshi, Natsume Jun, Kumai Sumire, Maki Yuki, Yamamoto Hiroyuki, Numoto Shingo, Narahara Sho, Kubota Tetsuo, Tsuji Takeshi, Kato Toru, Yamada Keitaro, Maruyama Koichi, Okumura Akihisa, Takahashi Yoshiyuki, Kidokoro Hiroyuki

    EPILEPSY & BEHAVIOR   Vol. 125   page: 108397   2021.12

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    DOI: 10.1016/j.yebeh.2021.108397

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  15. Physical functions and gait performance in school-aged children born late preterm

    Ito Yuji, Ito Tadashi, Sugiura Hideshi, Kidokoro Hiroyuki, Sugiyama Yuichiro, Mizusawa Jun, Natsume Jun, Noritake Koji, Kato Yuichi, Ochi Nobuhiko

    EARLY HUMAN DEVELOPMENT   Vol. 163   page: 105478   2021.12

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    DOI: 10.1016/j.earlhumdev.2021.105478

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  16. Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study. International journal

    Satoru Katsuki, Takafumi Ushida, Hiroyuki Kidokoro, Noriyuki Nakamura, Yukako Iitani, Kazuya Fuma, Kenji Imai, Tomoko Nakano-Kobayashi, Yoshiaki Sato, Masahiro Hayakawa, Jun Natsume, Hiroaki Kajiyama, Tomomi Kotani

    Early human development   Vol. 163   page: 105479 - 105479   2021.12

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    BACKGROUND: Infants born to mothers with hypertensive disorders of pregnancy (HDP) have adverse neurodevelopmental consequences in later life. Magnetic resonance spectroscopy (MRS) is used to predict subsequent neurodevelopment in the field of perinatology. AIM: We aimed to determine whether exposure to HDP in utero leads to alterations in brain metabolites in preterm infants using multi-voxel proton MRS at term-equivalent age. STUDY DESIGN: Retrospective cohort study. SUBJECTS: A total of 103 preterm infants born before 34 weeks of gestation at Nagoya University Hospital between 2010 and 2018 were eligible. Twenty-seven infants were born to mothers with HDP (HDP group), and 76 were born to mothers without HDP (non-HDP group). OUTCOME MEASURES: The peak area ratios of N-acetylaspartate (NAA)/choline (Cho), NAA/creatine (Cr), and Cho/Cr were evaluated at 10 designated regions of interest (bilateral frontal lobes, basal ganglia, thalami, temporal lobes, and occipital lobes). RESULTS: The peak area ratios of NAA/Cho and NAA/Cr in the bilateral thalami were significantly higher in the HDP group than in the non-HDP group after adjustment for covariates (postmenstrual age at MRS assessment and infant sex). No significant differences were observed in other regions. Preeclampsia, abnormal umbilical artery blood flow, and fetal growth restrictions were significantly associated with increased NAA/Cho and NAA/Cr ratios in the thalami. CONCLUSIONS: Based on the evidence that NAA/Cho and NAA/Cr ratios constantly increase with postmenstrual age in normal brain development, exposure to maternal HDP in utero may accelerate brain maturation and increase neuronal activity in preterm infants.

    DOI: 10.1016/j.earlhumdev.2021.105479

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  17. Trajectory of the incidence of brushes on preterm electroencephalogram and its association with neurodevelopment in extremely low birth weight infants

    Maeda Takashi, Kidokoro Hiroyuki, Tachibana Takashi, Shiraki Anna, Yamamoto Hiroyuki, Nakata Tomohiko, Fukasawa Tatsuya, Kubota Tetsuo, Sato Yoshiaki, Kato Toru, Natsume Jun, Okumura Akihisa, Hayakawa Masahiro

    BRAIN & DEVELOPMENT   Vol. 43 ( 10 ) page: 979 - 987   2021.11

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    DOI: 10.1016/j.braindev.2021.07.003

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  18. Repetitive sleep starts: An important differential diagnosis of infantile spasms

    Maki Yuki, Kidokoro Hiroyuki, Okumura Akihisa, Yamamoto Hiroyuki, Nakata Tomohiko, Fukasawa Tatsuya, Kubota Tetsuo, Kawaguchi Masahiro, Suzuki Takeshi, Tanaka Masaharu, Okai Yu, Sakaguchi Yoko, Ohno Atsuko, Negoro Tamiko, Takahashi Yoshiyuki, Natsume Jun

    EPILEPSY & BEHAVIOR   Vol. 121 ( Pt A ) page: 108075   2021.8

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    DOI: 10.1016/j.yebeh.2021.108075

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  19. Bilateral asymmetry in the gait deviation index in school-aged children with the trait of developmental coordination disorder. International journal

    Tadashi Ito, Yuji Ito, Akio Nakai, Hideshi Sugiura, Koji Noritake, Hiroyuki Kidokoro, Jun Natsume, Nobuhiko Ochi

    Gait & posture   Vol. 88   page: 174 - 179   2021.7

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    BACKGROUND: Although previous studies have identified asymmetry in gait parameters in children with developmental coordination disorder (DCD), they have not investigated whether these findings coexist with asymmetry in gait quality, as represented by the gait deviation index (GDI). RESEARCH QUESTION: This study sought to measure gait symmetry in children with traits of DCD (DCD trait) to elucidate the characteristic gait pattern. METHODS: This study included 172 (82 girls, 90 boys) participants with and without DCD trait (age: 6-12 years), as assessed using the Japanese version of the Developmental Coordination Disorder Questionnaire (DCDQ-J), which consists of three subscales. Three-dimensional gait analysis data were obtained during the gait trials. GDI, step length, and step time data were recorded for both the right and left legs, and symmetry ratios were calculated. RESULTS: Participants in the DCD trait group (n = 30) had a significantly lower GDI score (p < 0.0001) and a higher GDI symmetry ratio (p = 0.004) than typically developing children. Furthermore, DCD trait was related to the GDI symmetry ratio (odds ratio, 1.2; p = 0.001; 95 % confidence interval, 1.062-1.289). The control during movement, which was a DCDQ-J subscale, was negatively correlated with the GDI symmetry ratio (r=-0.257, p<0.001). SIGNIFICANCE: This study's results lend support to the hypothesis that an increase in the GDI symmetry ratio is associated with the DCD trait. A quantitative assessment of gait performance is important to help identify gait asymmetry, including gait quality, in children with a DCD trait. Children with a DCD trait have a poor ability to control the interaction of lower leg movements, which may cause bilateral asymmetry in gait quality.

    DOI: 10.1016/j.gaitpost.2021.05.027

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  20. Establishment of in-hospital clinical network for patients with neurofibromatosis type 1 in Nagoya University Hospital. International journal

    Yoshihiro Nishida, Kunihiro Ikuta, Atsushi Natsume, Naoko Ishihara, Maki Morikawa, Hiroyuki Kidokoro, Yukako Muramatsu, Norie Nonobe, Kanako Ishizuka, Takuya Takeichi, Miki Kanbe, Seiji Mizuno, Shiro Imagama, Norio Ozaki

    Scientific reports   Vol. 11 ( 1 ) page: 11933 - 11933   2021.6

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    Neurofibromatosis type 1 (NF1) is a genetic multisystem disorder. Clinicians must be aware of the diverse clinical features of this disorder in order to provide optimal care for it. We have set up an NF1 in-hospital medical care network of specialists regardless of patient age, launching a multidisciplinary approach to the disease for the first time in Japan. From January 2014 to December 2020, 246 patients were enrolled in the NF1 patient list and medical records. Mean age was 26.0 years ranging from 3 months to 80 years. The number of patients was higher as age at first visit was lower. There were 107 males (41%) and 139 females. After 2011, the number of patients has increased since the year when the medical care network was started. Regarding orthopedic signs, scoliosis was present in 60 cases (26%), and bone abnormalities in the upper arm, forearm, and tibia in 8 cases (3.5%). Neurofibromas other than cutaneous neurofibromas were present in 90 cases (39%), and MPNST in 17 cases (7.4%). We launched a multidisciplinary NF1 clinic system for the first time in Japan. For patients with NF1, which is a hereditary and systemic disease associated with a high incidence of malignant tumors, it will be of great benefit when the number of such clinics in Japan and the rest of Asia is increased.

    DOI: 10.1038/s41598-021-91345-6

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  21. MRI findings in children with congenital cytomegalovirus infection retrospectively diagnosed with dried umbilical cord

    Kidokoro Hiroyuki, Shiraki Anna, Torii Yuka, Tanaka Masaharu, Yamamoto Hiroyuki, Kurahashi Hirokazu, Maruyama Koichi, Okumura Akihisa, Natsume Jun, Ito Yoshinori

    NEURORADIOLOGY   Vol. 63 ( 5 ) page: 761 - 768   2021.5

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    DOI: 10.1007/s00234-020-02603-9

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  22. Risks of ACTH therapy for West syndrome following BCG vaccination

    Maki Yuki, Natsume Jun, Hori Ikumi, Takeuchi Tomoya, Negishi Yutaka, Kubota Tetsuo, Maruyama Koichi, Nakata Tomohiko, Yamamoto Hiroyuki, Tanaka Masaharu, Kawaguchi Masahiro, Suzuki Takeshi, Shiraki Anna, Sawamura Fumi, Kidokoro Hiroyuki

    EPILEPSY & BEHAVIOR   Vol. 118   page: 107924   2021.5

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    DOI: 10.1016/j.yebeh.2021.107924

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  23. The eldest case of MICPCH with CASK mutation exhibiting gross motor regression

    Nishio Yosuke, Kidokoro Hiroyuki, Takeo Toshiki, Narita Hajime, Sawamura Fumi, Narita Kotaro, Kawano Yoshihiko, Nakata Tomohiko, Muramatsu Hideki, Hara Shinya, Kaname Tadashi, Natsume Jun

    BRAIN & DEVELOPMENT   Vol. 43 ( 3 ) page: 459 - 463   2021.3

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    DOI: 10.1016/j.braindev.2020.11.007

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  24. Shuffling babies and autism spectrum disorder

    Okai Yu, Nakata Tomohiko, Miura Kiyokuni, Ohno Atsuko, Wakako Rie, Takahashi Osamu, Maki Yuki, Tanaka Masaharu, Sakaguchi Yoko, Ito Yuji, Yamamoto Hiroyuki, Kidokoro Hiroyuki, Takahashi Yoshiyuki, Natsume Jun

    BRAIN & DEVELOPMENT   Vol. 43 ( 2 ) page: 181 - 185   2021.2

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    DOI: 10.1016/j.braindev.2020.08.007

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  25. Initial treatment of seizures in children in an emergency department in rural Japan

    Shiraki Anna, Yasui Masahiro, Kidokoro Hiroyuki, Kido Shinji, Ando Hideo, Takahashi Yoshiyuki, Natsume Jun

    BRAIN & DEVELOPMENT   Vol. 43 ( 2 ) page: 288 - 293   2021.2

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    DOI: 10.1016/j.braindev.2020.08.004

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  26. Lenticular nuclei to thalamic ratio on PET is useful for diagnosis of GLUT1 deficiency syndrome

    Natsume Jun, Ishihara Naoko, Azuma Yoshiteru, Nakata Tomohiko, Takeuchi Tomoya, Tanaka Masaharu, Sakaguchi Yoko, Okai Yu, Ito Yuji, Yamamoto Hiroyuki, Ohno Atsuko, Kidokoro Hiroyuki, Hattori Ayako, Nabatame Shin, Kato Katsuhiko

    BRAIN & DEVELOPMENT   Vol. 43 ( 1 ) page: 69 - 77   2021.1

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    DOI: 10.1016/j.braindev.2020.07.001

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  27. Gait characteristics of children with Williams syndrome with impaired visuospatial recognition: a three-dimensional gait analysis study. Reviewed International journal

    Yuji Ito, Tadashi Ito, Naoko Kurahashi, Nobuhiko Ochi, Koji Noritake, Hideshi Sugiura, Seiji Mizuno, Hiroyuki Kidokoro, Jun Natsume, Miho Nakamura

    Experimental brain research   Vol. 238 ( 12 ) page: 2887 - 2895   2020.12

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    Williams syndrome (WS) is a genetically based neurodevelopmental disorder characterized by intellectual disability and impaired visuospatial recognition. The aim of this study was to analyze the gait characteristics of WS children with impaired visuospatial recognition using a three-dimensional gait analysis (3DGA) to clarify the gait adaptation needed to compensate for it. 3DGA was performed in 8 WS children with impaired visuospatial recognition (mean age, 11.8 years) and 9 age-, sex-, height-, and weight-matched controls. Clinical data, fundamental motor tests, and gait variables while walking on a flat surface and walking up a mat were compared between the two groups, and the correlations between variables were analyzed in the WS children. WS children showed impairment of balance function without muscle weakness. In walking on a flat surface, the WS group showed reduced walking speed, short step length, increased variability of step length, increased knee flexion throughout the stance phase, increased horizontal pelvic range of motion (ROM), and a low Gait Deviation Index and a high Gait Profile Score, which are indices of gait quality. In walking up a mat, the WS group showed further reduced walking speed and decreased sagittal hip flexion and ankle dorsiflexion ROM in the swing phase. Impaired balance function was significantly correlated with increased variability of step length and decreased sagittal ankle dorsiflexion ROM in the swing phase. The detailed gait pattern of WS children with impaired visuospatial recognition was presented. These findings show that impaired visuospatial recognition and balance function contribute to gait adaptation.

    DOI: 10.1007/s00221-020-05946-0

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  28. Evaluation of interobserver variability in application of the new neonatal seizure classification proposed by the ILAE Task Force. Reviewed International journal

    Tetsuo Kubota, Hiroyuki Kidokoro, Sho Narahara, Tatsuya Fukasawa, Tomohiko Nakata, Jun Natsume, Akihisa Okumura

    Epilepsy & behavior : E&B   Vol. 111   page: 107292 - 107292   2020.10

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    OBJECTIVE: Clinical identification of neonatal seizures (NS) remains challenging. The International League Against Epilepsy (ILAE) Task Force on Neonatal Seizures has proposed a new classification of NS, based on the 2017 ILAE seizure classification. One of the key points of this proposed NS classification is that seizure types should be determined by the "predominant" clinical feature. However, when the definition of "predominant" is uncertain, interobserver variability may arise. METHODS: We asked 49 health professionals to classify 21 NS video-electroencephalogram (EEG) recordings using the proposed 9 seizure types. RESULTS: The degree of agreement among participants was low, and agreement was weak among experts in neonatal neurology. Among experts, the rate of agreement was <50% for 2 NS. This disagreement was related to differences in the interpretation of "predominant features." Although interobserver variability was present among users of the new NS classification, the reproducibility of the NS classification was satisfactory. CONCLUSION: Education designed to foster consistent application of the standards for NS will be important for reducing interobserver variability and expanding the use of the new NS classification.

    DOI: 10.1016/j.yebeh.2020.107292

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  29. Change of White Matter Integrity in Children With Hematopoietic Stem Cell Transplantation. Reviewed International journal

    Yoko Sakaguchi, Jun Natsume, Hiroyuki Kidokoro, Masaharu Tanaka, Yu Okai, Yuji Ito, Hiroyuki Yamamoto, Atsuko Ohno, Tomohiko Nakata, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Hideki Muramatsu, Shinji Naganawa, Yoshiyuki Takahashi

    Pediatric neurology   Vol. 111   page: 78 - 84   2020.10

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    BACKGROUND: Advances in hematopoietic stem cell transplantation have improved the survival rate of malignant diseases and congenital immunodeficiencies. It has become important to assess long-term complications in survivors. To assess neurological abnormalities in children treated by transplantation, diffusion tensor imaging was performed. METHODS: Forty children who underwent head diffusion tensor imaging before and after their first transplantation were enrolled. Patients with brain lesions on conventional MRI were excluded. Fractional anisotropy and mean diffusivity were compared between patients and 28 control subjects using tract-based spatial statistics. The Strengths and Difficulties Questionnaire was administered as a behavioral evaluation after transplantation, and diffusion tensor images of patients with and without behavioral abnormalities were compared. RESULTS: The age of patients and controls was 0 to 19 years and 0 to 16 years, respectively. The date of diffusion tensor imaging was 10 to 57 days before and 40 to 153 days after transplantation. Tract-based spatial statistics showed fractional anisotropy reduction in widespread white matter in patients before and after transplantation. Mean diffusivity was high before transplantation and normalized after transplantation. Analysis comparing before and after hematopoietic stem cell transplantation shows no difference in fractional anisotropy and a higher mean diffusivity before hematopoietic stem cell transplantation. In patients with behavioral abnormalities, low fractional anisotropy and high mean diffusivity remained after transplantation. CONCLUSIONS: Longitudinal diffusion tensor imaging showed white matter abnormalities in children without conventional MRI abnormalities, which were related to behavioral problems after transplantation. Diffusion tensor imaging is useful for behavioral assessment in children undergoing transplantation.

    DOI: 10.1016/j.pediatrneurol.2020.06.008

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  30. Splenial Lesions in Benign Convulsions With Gastroenteritis Associated With Rotavirus Infection

    Ogawa Chikako, Kidokoro Hiroyuki, Ishihara Naoko, Tsuji Takeshi, Kurahashi Hirokazu, Hattori Ayako, Suzuki Motomasa, Ogaya Shunsuke, Ito Yuji, Fukasawa Tatsuya, Kubota Tetsuo, Okumura Akihisa, Saitoh Shinji, Natsume Jun

    PEDIATRIC NEUROLOGY   Vol. 109   page: 79 - 84   2020.8

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    DOI: 10.1016/j.pediatrneurol.2019.05.002

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  31. Transient cortical diffusion restriction in children immediately after prolonged febrile seizures

    Suzuki Takeshi, Kidokoro Hiroyuki, Kubota Tetsuo, Fukasawa Tatsuya, Suzui Ryosuke, Tsuji Takeshi, Kato Toru, Yamamoto Hiroyuki, Ohno Atsuko, Nakata Tomohiko, Saitoh Shinji, Okumura Akihisa, Natsume Jun

    EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY   Vol. 27   page: 30 - 36   2020.7

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    DOI: 10.1016/j.ejpn.2020.05.004

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  32. Clinical findings in patients with febrile seizure after 5 years of age: A retrospective study. Reviewed International journal

    Motoko Ogino, Mitsuru Kashiwagi, Takuya Tanabe, Chizu Oba, Shohei Nomura, Shuichi Shimakawa, Hiroyuki Kidokoro, Jun Natsume, Akihisa Okumura, Hiroshi Tamai, Akira Ashida

    Brain & development   Vol. 42 ( 6 ) page: 449 - 456   2020.6

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    OBJECTIVE: Febrile seizures (FSs) typically occur in infants and children between 6 and 60 months of age. Rarely, FS can occur in late childhood (late FS [LFS]; >5 years of age); however, the clinical features of LFS remain unclear. We aimed to clarify the clinical features of LFS. METHODS: We retrospectively analyzed data from patients with LFS who visited Hirakata City Hospital between January 2004 and December 2014. We defined LFS as a seizure accompanied by fever (temperature ≥38 °C) occurring after 5 years of age, without a central nervous system infection. RESULTS: A total of 505 patients (349 boys, 156 girls: 5-14 years old) were included. A history of FS before 60 months of age was observed in 319 of 460 patients (69.3%) with sufficient information about previous FS history among the 505 patients enrolled. LFS was more likely to occur in males (69.1%). Seizure duration was ≤15 min in 87.4% of cases. A family history of FS in first-degree relatives was observed in 103/327 cases (31.5%). Among LFS cases, 45% occurred at 5 years of age, and 92.1% experienced only one seizure after 5 years of age. The number of seizure episodes gradually lessened with age, decreasing drastically to 5.6% of cases older than 9 years. CONCLUSIONS: Our findings suggest that sex differences, seizure duration, and family history were similar for LFS and FS. Over 90% patients with LFS experienced no recurrence after 5 years of age. Further study is needed to verify the recurrence rate of LFS.

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  33. Biallelic VPS35L pathogenic variants cause 3C/Ritscher-Schinzel-like syndrome through dysfunction of retriever complex Reviewed

    Kohji Kato, Yasuyoshi Oka, Hideki Muramatsu, Filipp F Vasilev, Takanobu Otomo, Hisashi Oishi, Yoshihiko Kawano, Hiroyuki Kidokoro, Yuka Nakazawa, Tomoo Ogi, Yoshiyuki Takahashi, Shinji Saitoh

    Journal of Medical Genetics   Vol. 57 ( 4 ) page: 245 - 253   2020.4

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    <sec><title>Background</title>3C/Ritscher-Schinzel syndrome is characterised by congenital cranio-cerebello-cardiac dysplasia, where <italic>CCDC22</italic> and <italic>WASHC5</italic> are accepted as the causative genes. In combination with the retromer or retriever complex, these genes play a role in endosomal membrane protein recycling. We aimed to identify the gene abnormality responsible for the pathogenicity in siblings with a 3C/Ritscher-Schinzel-like syndrome, displaying cranio-cerebello-cardiac dysplasia, coloboma, microphthalmia, chondrodysplasia punctata and complicated skeletal malformation.

    </sec><sec><title>Methods</title>Exome sequencing was performed to identify pathogenic variants. Cellular biological analyses and generation of knockout mice were carried out to elucidate the gene function and pathophysiological significance of the identified variants.

    </sec><sec><title>Results</title>We identified compound heterozygous pathogenic variants (c.1097dup; p.Cys366Trpfs*28 and c.2755G&gt;A; p.Ala919Thr) in the <italic>VPS35L</italic> gene, which encodes a core protein of the retriever complex. The identified missense variant lacked the ability to form the retriever complex, and the frameshift variant induced non-sense-mediated mRNA decay, thereby confirming biallelic loss of function of VPS35L. In addition, <italic>VPS35L</italic> knockout cells showed decreased autophagic function in nutrient-rich and starvation conditions, as well as following treatment with Torin 1. We also generated <italic>Vps35l<sup>−/−</sup></italic> mice and demonstrated that they were embryonic lethal at an early stage, between E7.5 and E10.5.

    </sec><sec><title>Conclusions</title>Our results suggest that biallelic loss-of-function variants in <italic>VPS35L</italic> underlies 3C/Ritscher-Schinzel-like syndrome. Furthermore, VPS35L is necessary for autophagic function and essential for early embryonic development. The data presented here provide a new insight into the critical role of the retriever complex in fetal development.

    </sec>

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  34. Subsecond EEG-fMRI analysis for presurgical evaluation in focal epilepsy

    Ito Yuji, Maesawa Satoshi, Bagarinao Epifanio, Okai Yu, Nakatsubo Daisuke, Yamamoto Hiroyuki, Kidokoro Hiroyuki, Usui Naotaka, Natsume Jun, Hoshiyama Minoru, Wakabayashi Toshihiko, Sobue Gen, Ozaki Norio

    JOURNAL OF NEUROSURGERY   Vol. 134 ( 4 ) page: 1027 - 1036   2020.4

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    DOI: 10.3171/2020.1.JNS192567

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  35. Pseudo-sawtooth pattern on amplitude-integrated electroencephalography in neonatal hypoxic-ischemic encephalopathy

    Tanaka Masaharu, Kidokoro Hiroyuki, Kubota Tetsuo, Fukasawa Tatsuya, Okai Yu, Sakaguchi Yoko, Ito Yuji, Yamamoto Hiroyuki, Ohno Atsuko, Nakata Tomohiko, Negoro Tamiko, Okumura Akihisa, Kato Toru, Watanabe Kazuyoshi, Takahashi Yoshiyuki, Natsume Jun

    PEDIATRIC RESEARCH   Vol. 87 ( 3 ) page: 529 - 535   2020.2

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    DOI: 10.1038/s41390-019-0567-5

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  36. Novel biallelic FA2H mutations in a Japanese boy with fatty acid hydroxylase-associated neurodegeneration

    Kawaguchi Masahiro, Sassa Takayuki, Kidokoro Hiroyuki, Nakata Tomohiko, Kato Kohji, Muramatsu Hideki, Okuno Yusuke, Yamamoto Hiroyuki, Kaname Tadashi, Kihara Akio, Natsume Jun

    BRAIN & DEVELOPMENT   Vol. 42 ( 2 ) page: 217 - 221   2020.2

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    DOI: 10.1016/j.braindev.2019.11.006

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  37. A Case of a 14-Year-Old Boy who had Difficulty Walking Due to Drug-Induced Neuropathy During T-Cell Acute Lymphocytic Leukemia Treatment

    Yoshida Taro, Sawamura Aya, Muramatsu Hideki, Imaya Masayuki, Yamamori Ayako, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Taniguchi Rieko, Ichikawa Daisuke, Nishikawa Eri, Hamada Motoharu, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Nakata Tomohiko, Kidokoro Hiroyuki, Natxume Jun, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   Vol. 66   page: S30 - S30   2019.12

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  38. Risk factors for absence of catch-up growth in small for gestational age very low-birthweight infants

    Arai Sakiko, Sato Yoshiaki, Muramatsu Hideki, Yamamoto Hidenori, Aoki Fumiko, Okai Yu, Kataoka Shinsuke, Hanada Yu, Hamada Motoharu, Morimoto Yoshihito, Kojima Seiji, Natsume Jun, Takahashi Yoshiyuki, Sugiyama Yuichiro, Hoshino Shin, Kawada Junichi, Kidokoro Hiroyuki, Hayakawa Masahiro, Hattori Tetsuo, Kato Yuichi, Yasuda Ayako, Oshiro Makoto, Takemoto Koji, Nishimura Naoko, Hayashi Seiji, Hyodo Reina, Ito Masatoki, Narahara Shou, Ieda Kuniko, Yamamoto Hikaru

    PEDIATRICS INTERNATIONAL   Vol. 61 ( 9 ) page: 889 - 894   2019.9

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    DOI: 10.1111/ped.13939

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  39. Comparison of Clinical Characteristics of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Young Children

    Taniguchi Akinobu, Kawada Jun-ichi, Go Kiyotaka, Fujishiro Naozumi, Hosokawa Yosuke, Maki Yuki, Sugiyama Yuichiro, Suzuki Michio, Tsuji Takeshi, Hoshino Shin, Muramatsu Hideki, Kidokoro Hiroyuki, Kinoshita Fumie, Hirakawa Akihiro, Takahashi Yoshiyuki, Sato Yoshiaki, Natsume Jun, Nagoya Collaborative Clinical Research Team

    Japanese Journal of Infectious Diseases   Vol. 72 ( 4 ) page: 237 - 242   2019.7

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    <p>Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are the leading causes of acute respiratory tract infection in children, and clinical manifestations of these virus infections are considered similar. To investigate the differences in clinical characteristics between HMPV and RSV infections in young children, we prospectively enrolled children < 3 years old who required hospitalization with acute respiratory tract infection due to HMPV or RSV at 10 hospitals in Japan. We enrolled 48 children with HMPV infection and 141 with RSV infection. Patients with HMPV infection were older than those with RSV infection. High-grade fever was more frequently observed in patients with HMPV infection, whereas no significant differences in respiratory symptoms were apparent. Abnormal serum lactate dehydrogenase values and consolidation shadows on chest X-ray were more frequently observed in patients with HMPV infection. During hospitalization, nasal mucus suction was more frequently required in patients with RSV infection. On the other hand, β2-adrenergic agonists, corticosteroids, and leukotriene receptor antagonists were more frequently used in patients with HMPV infection. These findings suggest that HMPV and RSV infections show similar respiratory symptoms, but HMPV infection is more likely to lead to the development of pneumonia, at least among hospitalized young children.</p>

    DOI: 10.7883/yoken.JJID.2018.480

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    CiNii Research

  40. Hippocampal diffusion abnormality after febrile status epilepticus is related to subsequent epilepsy Reviewed International journal

    Setsuri Yokoi, Hiroyuki Kidokoro, Hiroyuki Yamamoto, Atsuko Ohno, Tomohiko Nakata, Tetsuo Kubota, Takeshi Tsuji, Masashi Morishita, Takashi Kawabe, Misako Naiki, Koichi Maruyama, Kazuya Itomi, Toru Kato, Komei Ito, Jun Natsume

    Epilepsia   Vol. 60 ( 7 ) page: 1306 - 1316   2019.7

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    OBJECTIVE: To assess hippocampal signal changes on diffusion-weighted imaging (DWI) during the acute period after febrile status epilepticus (FSE) and to examine the relationship between DWI and subsequent epilepsy. METHODS: A prospective, multicenter study of children with a first episode of FSE was performed. The patients underwent magnetic resonance imaging (MRI) within 3 days of FSE, and signal intensity was evaluated on DWI. Electroencephalography studies within 3 days of FSE were also assessed. Nine to 13 years after FSE, information on subsequent epilepsy was obtained. RESULTS: Twenty-two children with FSE were evaluated. DWI showed unilateral hippocampal hyperintensity in six patients (27%). Three of six patients with hippocampal hyperintensity had ipsilateral thalamic hyperintensity. On EEG within 3 days of FSE, five of six patients with hippocampal hyperintensity had ipsilateral focal slowing, spikes, or attenuation. Nine to 13 years later, the outcomes could be determined in five patients with hippocampal hyperintensity and in 10 without. All 5 patients with hippocampal hyperintensity had hippocampal atrophy and developed focal epilepsy, whereas only 1 of 10 patients without hippocampal hyperintensity developed epilepsy (P = 0.002). Ictal semiology was concordant with temporal lobe seizures in all patients. Ipsilateral temporal epileptiform abnormalities were seen on EEG in four of five at last follow-up. SIGNIFICANCE: Acute DWI hippocampal hyperintensity was seen in 27% of patients with FSE. Acute DWI hyperintensity suggests cytotoxic edema caused by prolonged seizure activity. Hippocampal DWI hyperintensity is related to mesial temporal lobe epilepsy and can be a target of neuroprotective treatments to prevent the onset of epilepsy.

    DOI: 10.1111/epi.16059

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/epi.16059

  41. Comparison of high-dose and low-dose corticosteroid therapy for refractory Mycoplasma pneumoniae pneumonia in children. Reviewed International journal

    Toshihiko Okumura, Jun-Ichi Kawada, Masaharu Tanaka, Kotaro Narita, Tomonori Ishiguro, Yuji Hirayama, Sho Narahara, Genki Tsuji, Yuichiro Sugiyama, Michio Suzuki, Takeshi Tsuji, Shin Hoshino, Masahiro Nakatochi, Hideki Muramatsu, Hiroyuki Kidokoro, Yoshiyuki Takahashi, Yoshiaki Sato

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   Vol. 25 ( 5 ) page: 346 - 350   2019.5

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    BACKGROUND: Mycoplasma pneumoniae pneumonia (MPP) is generally a self-limiting disease, but it may become refractory. It is thought that refractory MPP is linked to the excessive immunologic responses of the host. Consequently, the use of adjunctive systemic corticosteroids may have beneficial effects. In this study, we compared the effects of high- and low-dose corticosteroid therapy in a pediatric population with refractory MPP. METHODS: We retrospectively collected data from 91 pediatric MPP patients treated with adjunctive systemic corticosteroids between April 2014 and October 2016. The patients were divided into the following two groups: high-dose corticosteroid group (2 mg/kg/day or more of prednisolone equivalents; n = 38) and low-dose corticosteroid group (<2 mg/kg/day; n = 53). Additionally, we compared the number of febrile days post-corticosteroid administration. We used 25 paired patients in a propensity score matching analysis to correct for confounding factors both by age and by days (from onset till corticosteroid therapy initiation). RESULTS: We observed that in the high-dose corticosteroid group defervescence following corticosteroid therapy initiation was achieved significantly earlier and length of hospitalization was significantly shorter (0.8 ± 1.0 vs. 1.5 ± 1.4 days and 8.2 ± 2.4 vs. 10.7 ± 2.7 days, respectively). In the propensity score matching, we observed that significant differences in the length of fever following corticosteroid therapy initiation and hospitalization were still present. Further, neither of the groups developed corticosteroid-related adverse events. CONCLUSION: Our results suggest that patients with refractory MPP treated with high-dose corticosteroid could achieve defervescence earlier and have a shorter hospitalization.

    DOI: 10.1016/j.jiac.2019.01.003

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  42. Design of a prospective multicenter randomized controlled trial evaluating the effects of gastric lavage on coffee-ground emesis in neonates: study protocol. Reviewed

    Takashi Maeda, Yoshiaki Sato, Akihiro Hirakawa, Masahiro Nakatochi, Fumie Kinoshita, Takeshi Suzuki, Shintaro Ichimura, Ryoichi Ito, Ryuji Kudo, Michio Suzuki, Shin Hoshino, Yuichiro Sugiyama, Hideki Muramatsu, Hiroyuki Kidokoro, Jun-Ichi Kawada, Yoshiyuki Takahashi

    Nagoya journal of medical science   Vol. 81 ( 2 ) page: 227 - 232   2019.5

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    Neonates who swallow a considerable amount of maternal blood may exhibit vomiting and suckling disorder during the first few days of the postnatal period. Some clinicians treat these neonates with gastric lavage (GL) to prevent vomiting and the establishment of enteral feeding empirically, but there was no study assessing the effect of GL for neonates with coffee-ground emesis. We designed a multicenter randomized controlled trial to evaluate the efficacy and safety of GL in neonates with coffee-ground emesis. Vigorous neonates with birth weight ranging from 2500 g to 3999 g and gestational age between 37w0d and 41w6d who presented with coffee-ground emesis on more than twice and diagnosed as false melena, were divided into two groups using computerized randomization. We defined feeding intolerance (FI) as (1) ≥2 vomiting episodes in 4h or ≥3 episodes in 24h and/or (2) feeding failure on at least two occasions because of retching or poor sucking. Primary outcome is percentage of infants who present FI within 24 hours from admission. We also assessed the residual volumes, number of vomiting episodes, percentage of weight reduction at postnatal day 4, rates of body weight gain at 1 month of age, and peak serum total bilirubin value before discharge. To our knowledge, this is the first study to evaluate the safety and efficacy of GL for neonates with coffee-ground emesis. This trial is registered at UMIN Clinical Trials Registry as UMIN000026483.

    DOI: 10.18999/nagjms.81.2.227

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  43. Thirteen-Year Outcomes in Very Preterm Children Associated with Diffuse Excessive High Signal Intensity on Neonatal Magnetic Resonance Imaging.

    The Journal of pediatrics   Vol. 206   page: 66 - +   2019.3

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    DOI: 10.1016/j.jpeds.2018.10.016

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  44. Correction: Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: A non-inferiority randomized control trial. Reviewed International journal

    Chikako Ogawa, Yoshiaki Sato, Chiyo Suzuki, Azusa Mano, Atsushi Tashiro, Takafumi Niwa, Sayako Hamazaki, Yoshihiro Tanahashi, Midori Suzumura, Satoshi Hayano, Masahiro Hayakawa, Takeshi Tsuji, Shin Hoshino, Yuichiro Sugiyama, Hiroyuki Kidokoro, Jun-Ichi Kawada, Hideki Muramatsu, Akihiro Hirakawa, Masahiko Ando, Jun Natsume, Seiji Kojima

    PloS one   Vol. 14 ( 6 ) page: e0218205   2019

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    [This corrects the article DOI: 10.1371/journal.pone.0192688.].

    DOI: 10.1371/journal.pone.0218205

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  45. Longitudinal Findings of MRI and PET in West Syndrome with Subtle Focal Cortical Dysplasia

    Sakaguchi Y., Kidokoro H., Ogawa C., Okai Y., Ito Y., Yamamoto H., Ohno A., Nakata T., Tsuji T., Nakane T., Kawai H., Kato K., Naganawa S., Natsume J.

    AMERICAN JOURNAL OF NEURORADIOLOGY   Vol. 39 ( 10 ) page: 1932-1937   2018.10

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    DOI: 10.3174/ajnr.A5772

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  46. Magnetic resonance spectroscopy in preterm infants: association with neurodevelopmental outcomes.

    Hyodo R, Sato Y, Ito M, Sugiyama Y, Ogawa C, Kawai H, Nakane T, Saito A, Hirakawa A, Kidokoro H, Natsume J, Hayakawa M

    Archives of disease in childhood. Fetal and neonatal edition   Vol. 103 ( 3 ) page: F238 - F244   2018.5

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    DOI: 10.1136/archdischild-2016-311403

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  47. Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: A non-inferiority randomized control trial.

    Ogawa C, Sato Y, Suzuki C, Mano A, Tashiro A, Niwa T, Hamazaki S, Tanahashi Y, Suzumura M, Hayano S, Hayakawa M, Tsuji T, Hoshino S, Sugiyama Y, Kidokoro H, Kawada JI, Muramatsu H, Hirakawa A, Ando M, Natsume J, Kojima S

    PloS one   Vol. 13 ( 2 ) page: e0192688   2018.2

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    DOI: 10.1371/journal.pone.0192688

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  48. Cytotoxic edema at onset in West syndrome of unknown etiology: A longitudinal diffusion tensor imaging study Reviewed International journal

    Chikako Ogawa, Hiroyuki Kidokoro, Tatsuya Fukasawa, Hiroyuki Yamamoto, Naoko Ishihara, Yuji Ito, Yoko Sakaguchi, Yu Okai, Atsuko Ohno, Tomohiko Nakata, Yoshiteru Azuma, Ayako Hattori, Tetsuo Kubota, Takeshi Tsuji, Akihiro Hirakawa, Hisashi Kawai, Jun Natsume

    Epilepsia   Vol. 59 ( 2 ) page: 440 - 448   2018.2

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    OBJECTIVE: To clarify longitudinal changes in white matter microstructures from the onset of disease in patients with West syndrome (WS) of unknown etiology. METHODS: Diffusion tensor imaging (DTI) was prospectively performed at onset and at 12 and 24 months old in 17 children with WS of unknown etiology. DTI was analyzed using tract-based spatial statistics (TBSS) and tract-specific analysis (TSA) of 13 fiber tracts, and fractional anisotropy (FA) and mean diffusivity (MD) were compared with those of 42 age-matched controls. Correlations of FA and MD with developmental quotient (DQ) at age 24 months were analyzed. Multiple comparisons were adjusted for using the false discovery rate (q-value). RESULTS: TBSS analysis at onset showed higher FA and lower MD in the corpus callosum and brainstem in patients. TSA showed lower MD in bilateral uncinate fasciculi (UF) (right: q < 0.001; left: q = 0.03) at onset in patients. TBSS showed a negative correlation between FA at onset and DQ in the right frontal lobe, whereas FA at 24 months old exhibited a positive correlation with DQ in the diffuse white matter. MD for bilateral UF at 24 months old on TSA correlated positively with DQ (q = 0.04, both). SIGNIFICANCE: These findings may indicate the existence of cytotoxic edema in the immature white matter and dorsal brainstem at onset, and subsequent alterations in the diffuse white matter in WS of unknown etiology. Microstructural development in the UF might play important roles in cognitive development in WS.

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  49. Predominant area of brain lesions in neonates with herpes simplex encephalitis

    Kidokoro H., de Vries L. S., Ogawa C., Ito Y., Ohno A., Groenendaal F., Saitoh S., Okumura A., Ito Y., Natsume J.

    JOURNAL OF PERINATOLOGY   Vol. 37 ( 11 ) page: 1210-1214   2017.11

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    DOI: 10.1038/jp.2017.114

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  50. Phenotype-genotype correlations of PIGO deficiency with variable phenotypes from infantile lethality to mild learning difficulties

    Tanigawa Junpei, Mimatsu Haruka, Mizuno Seiji, Okamoto Nobuhiko, Fukushi Daisuke, Tominaga Koji, Kidokoro Hiroyuki, Muramatsu Yukako, Nishi Eriko, Nakamura Shota, Motooka Daisuke, Nomura Noriko, Hayasaka Kiyoshi, Niihori Tetsuya, Aoki Yoko, Nabatame Shin, Hayakawa Masahiro, Natsume Jun, Ozono Keiichi, Kinoshita Taroh, Wakamatsu Nobuaki, Murakami Yoshiko

    HUMAN MUTATION   Vol. 38 ( 7 ) page: 805-815   2017.7

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    DOI: 10.1002/humu.23219

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  51. Preterm brain injury on term-equivalent age MRI in relation to perinatal factors and neurodevelopmental outcome at two years

    Brouwer Margaretha J., Kersbergen Karina J., van Kooij Britt J. M., Benders Manon J. N. L., van Haastert Ingrid C., Koopman-Esseboom Corine, Neil Jeffrey J., de Vries Linda S., Kidokoro Hiroyuki, Inder Terrie E., Groenendaal Floris

    PLOS ONE   Vol. 12 ( 5 ) page: e0177128   2017.5

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    DOI: 10.1371/journal.pone.0177128

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  52. Paroxysmal nonepileptic events in children with epilepsy

    Ito Yuji, Kidokoro Hiroyuki, Negoro Tamiko, Tanaka Masaharu, Okai Yu, Sakaguchi Yoko, Ogawa Chikako, Takeuchi Tomoya, Ohno Atsuko, Yamamoto Hiroyuki, Nakata Tomohiko, Maesawa Satoshi, Watanabe Kazuyoshi, Takahashi Yoshiyuki, Natsume Jun

    EPILEPSY RESEARCH   Vol. 132   page: 59-63   2017.5

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    DOI: 10.1016/j.eplepsyres.2017.02.009

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MISC 5

  1. FDG-PETとEEG-fMRIを用いててんかん焦点、てんかん性ネットワークの継時的評価を行った結節性硬化症の1例

    牧 祐輝, 伊藤 祐史, 岡井 佑, 白木 杏奈, 川口 将宏, 鈴木 健史, 田中 雅大, 坂口 陽子, 山本 啓之, 中田 智彦, 城所 博之, 前澤 聡, バガリナオ・エピファニオ, 寳珠山 稔, 夏目 淳

    てんかん研究   Vol. 37 ( 3 ) page: 838 - 838   2020.1

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    Language:Japanese   Publisher:(一社)日本てんかん学会  

  2. ILAEが提唱する新しい新生児発作分類の妥当性について

    久保田 哲夫, 奥村 彰久, 楢原 翔, 深沢 達也, 根来 民子, 中田 智彦, 城所 博之, 夏目 淳

    てんかん研究   Vol. 37 ( 2 ) page: 539 - 539   2019.9

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  3. EBウィルス感染に伴った急性脳症の一女児例

    重松 拓朗, 内木 美紗子, 水谷 修平, 竹内 陽平, 尾池 直子, 加藤 俊輔, 前田 徹, 小林 貴江, 足達 武憲, 星野 伸, 河邊 太加志, 奥村 俊彦, 城所 博之, 伊藤 嘉規, 夏目 淳, 谷内江 昭宏

    日本小児科学会雑誌   Vol. 123 ( 2 ) page: 367 - 367   2019.2

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  4. CHRNG変異を有するEscobar症候群の3例

    中田 智彦, 水野 誠司, 牧 祐輝, 田中 雅大, 岡井 佑, 坂口 陽子, 山本 啓之, 大野 敦子, 城所 博之, 井本 逸勢, 大野 欽司, 夏目 淳

    脳と発達   Vol. 50 ( Suppl. ) page: S363 - S363   2018.5

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  5. aEEGによる早産児の脳成熟度評価 受胎後齢の判定基準とその精度

    加藤 徹, 辻 健史, 早川 文雄, 久保田 哲夫, 城所 博之, 夏目 淳, 奥村 彰久

    脳と発達   Vol. 49 ( Suppl. ) page: S357 - S357   2017.5

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KAKENHI (Grants-in-Aid for Scientific Research) 7

  1. 先進的MRI解析によるDuchenne型筋ジストロフィーの脳構造・機能異常の解明

    Grant number:20K08204  2020.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    夏目 淳, 久保田 一生, 城所 博之, 服部 文子

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    D/BMD患者30名、健常小児20名のMRI撮像、2022年度に画像解析を行い、以下を明らかにし、D/BMD患者における認知・精神発達特性の基盤を明らかにし、リハビリテーション、呼吸補助装置、意思伝達デバイスを用いる際の参考になる情報を得る。研究成果を学会発表し、論文として報告する。
    1) 健常者と比較したD/BMD患者の脳の微細構造、脳機能の異常を明らかにする。2) D/BMDのうち、知的障害、発達障害を持つ患者の脳構造、脳機能の特徴を明らかにする。3) D/BMDのうち、遺伝子検査でDp140の有無による脳の微細構造、脳機能の異常を明らかにする。
    研究を開始するにあたって、Duchenne型およびBecker型の筋ジストロフィー(DMD/BMD)の患者および健常小児で安全に高磁場MRI検査を行い、結果の解析が可能なことを再確認した。その上で、研究協力施設において本研究の広報を行い研究参加希望者を確認した。研究内容の説明を行い文書による同意の上で、2021年3月までに6歳から19歳のDMD/BMD患者16名、コントロールとして用いる6歳から2歳の健常小児・若年成人25例でMRI撮像を行った。合わせて患者群においてレーヴン色彩マトリックス検査、絵画語彙発達検査、自閉症スペクトラム指数(AQ)、ADHD-Rating scale(ADHD-RS)の評価を行った。そして画像解析プログラムを用いて、中間解析として拡散テンソル画像から白質線維の脳各部位の結合性の評価し患者と健常小児の脳ネットワーク構造の違いの検出を試みている。現時点の解析では患者において左右の上後頭回、左中後頭回、左楔前部など後頭葉の視覚認知に関連する領域の結合性の低下が示唆されている。画像や臨床情報の保存、管理も支障なく行っている。
    今後は、本研究に参加する患者数、健常小児を増やし、Voxel-based morphometry、安静時-機能的MRIの評価を加えていく。また、画像解析結果と神経心理学的検査との相関、遺伝子変異との関連を評価していく。以上の研究によってDMD/BMD患者の知的障害、発達障害に関連する脳の微細構造、脳機能の異常を明らかにして、患者の日常的ケアやコンピュータデバイスを用いた意思疎通にも有用な情報を提供する。得られた研究成果を国内および国際学会、医学雑誌で公表する。
    患者および家族への研究の広報や説明、コントロールとして用いる健常小児の募集を予定通り行った。患者16名、健常小児25例の撮像を行い、被検者の体調不良などの問題なく続けられている。研究分担者、研究補助者、研究協力者との連携も問題なく行えている。MRIの撮像、結果の中間解析も進められている。更なる患者および健常小児の撮像、画像解析の継続を行っていく。
    本研究に参加する患者数を増やすために、東海地区の医療機関に対象患者の確認を行い、また健常小児の撮像について広報をしていく。Voxel-based morphometry、安静時-機能的MRIの評価を加えていく。また、画像解析結果と神経心理学的検査との相関、遺伝子変異との関連を評価していく。以上の研究によってDMD/BMD患者の知的障害、発達障害に関連する脳の微細構造、脳機能の異常を明らかにして、患者の日常的ケアやコンピュータデバイスを用いた意思疎通にも有用な情報を提供する。得られた研究成果を国内および国際学会、医学雑誌で公表する。

  2. 脳波-近赤外分光法同時記録を用いたサブプレート・ニューロンの脳血流動態の解明

    Grant number:20K08228  2020.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    城所 博之, 多賀 厳太郎, 夏目 淳

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    サブプレート・ニューロンは、発達期の脳皮質の形成や脳内ネットワークの構築に重要な役割を果たす。ヒト早産児に高率に認める発達障害の病態にも、サブプレート・ニューロンの障害が大きく関与すると考えるが、ヒトでは未解明である。動物実験を通じて、ヒト早産児脳波に見られるブラッシュがサブプレート・ニューロンの活動を反映することが示された。本研究では、1) 脳波に機能的近赤外分光法(fNIRS)を同時記録することでサブプレート・ニューロンの脳局所血流動態を明らかにする。さらに、2) サブプレート・ニューロンの活動が、生後18か月の神経発達や脳皮質構造や脳内ネットワークに及ぼす効果を明らかにする。
    本研究の目的は、ヒト早産児を対象に、1)脳波と機能的近赤外分光法(fNIRS)の同時記録を多チャンネルで行い、サブプレート・ニューロンの神経活動に応答する脳血流反応を明らかにすることである。さらに、2) サブプレート・ニューロンの活動動態が、将来の脳構造や脳機能、神経ネットワーク形成に及ぼす影響を明らかにすることである。本研究は、げっ歯類の実験から導かれた仮説である「サブプレート・ニューロンが胎生期の脳発達や神経ネットワーク構築に重要な役割を果たす」ことをヒトで実証する意義がある。
    令和2年度は、名古屋大学医学部附属病院における在胎22~32週の早産児で、研究参加に同意が得られた早産児30例に対し、安静睡眠時に約60分の脳波-fNIRS同時記録をNICU内あるいは脳波室で施行した。記録は修正30週~44週まで反復して行い、各症例で1~4記録(合計82記録)を行った。次に、得られた脳波データを用い、睡眠覚醒あるいは動睡眠と静睡眠の各ステート分類を視察的に行い、NIRSデータとの関係を検討した。その結果、動睡眠では静睡眠と比較し、NIRSが捉える安静時ネットワークのチャネル間同期性が高値となることを明らかにした。このことは、安静時ネットワークが睡眠ステージで異なる可能性を強く示唆する重要な成果である。さらに、安静時ネットワークが在胎週数が増すにつれて発達的に変化することが示唆された。今後は、症例を積み重ね、集団解析を施行する予定である。
    一方、脳波上に観察されるデルタブラッシュを自動検出するアルゴリズムの開発については、令和2年度は、研究分担者らとともに抽出すべき波形の特徴やモンタージュの選択について議論を重ね試行錯誤を重ねた。令和3年度での完成を目標としている。
    当初見込まれた研究対象者の数を上回るペースで脳波-機能的NIRSの測定を施行できており、脳波やNIRSのデータ解析も順調に進行中である。次年度も引き続き、研究対象者のリクルートを行う予定である。
    令和3年度は、早産児脳波からデルタブラッシュを検出するアルゴリズムの開発と検証を中心に研究を進める。早産児に対する脳波-機能的NIRSの記録は令和3年度も引き続き行い、データを収集する。さらに、対象の早産児を前方視的に追跡し、名古屋大学医学部附属病院にある3テスラ高磁場MRIを用いて、18か月で三次元脳構造MRI画像及び安静時機能的MRIを撮像する。解析には専用のソフトウエア(MATLAB,SPM,Carretなど)を使用し、脳構造画像からは、大脳皮質容量、皮質厚、脳表面積や脳回指数などを計測する。安静時機能的MRIからは、脳内ネットワークの解析を、独立成分分析法、グラフ理論、クラスター解析を用いて行う。また、修正18か月に当院発達外来で神経学的評価及び行動発達評価を行う。小児神経専門医が包括的な神経学的評価を行う。発達検査は、臨床心理士がBayleyⅢ発達評価とM-chatを含む自閉症スクリーニングを行う。

  3. 脳溝形成の個人差に着目した早産児神経発達予後予測モデルの開発

    Grant number:19H04900  2019.4 - 2021.3

    新学術領域研究(研究領域提案型)

    城所 博之

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    ヒトの大脳の脳溝パターンは遺伝要因と環境要因が織りなすフィンガー・プリント(指紋)であり、脳溝パターンには個性が宿る。近年、ヒト成人の脳溝パターンと認知機能や神経発達症との関連が報告され始めている。本研究は、環境要因が強く反映するヒト早産児の多様な脳溝パターンと多彩な神経発達症との関係を最新のMRI技術から明らかにし、脳溝パターンに着目した神経発達予後予測モデルを開発する。さらに、最近私達が見出した「特異な中心溝」をもつ早産児の運動機能、高次脳機能を明らかにすることで、個々の脳溝パターンの臨床意義を明らかにする。
    ヒトの大脳の脳溝パターンは遺伝要因と環境要因が織りなすフィンガー・プリント(指紋)であり、脳溝パターンには個性が宿る。近年、ヒト成人の脳溝パターンと認知機能や神経発達症との関連が報告され始めている。本研究の目的は、環境要因が強く反映するヒト早産児の多様な脳溝パターンと多彩な神経発達症との関係を最新のMRI技術から明らかにし、脳溝パターンに着目した神経発達予後予測モデルを開発することである。また、私達が見出した「特異な中心溝」をもつ早産児の運動機能、高次脳機能を明らかにすることである。
    初年度は、名古屋大学医学部附属病院NICUで入院管理された在胎30週以下の早産児(コホートA)の6歳で施行された脳構造MRI画像約20例と共同研究施設である安城更生病院NICUで入院管理された在胎30週以下の早産児(コホートB)の6歳時の脳構造MRI画像約100例のうち、早産児特有の重篤な脳障害例を除外した合計120例の脳構造MRIを対象として抽出した。各症例のMRI画像をFreeSurferを用い、脳各領域の体積や大脳皮質表面積や皮質厚を解析した。次に、脳溝解析(surface-based analysis:VanEssen.NeuroImage 2012)は、caretver5.65ソフトウエアを用いて構築された3次元脳表面画像から、脳表面積、脳回指数などの各種パラメータや、中心溝の深さ、長さ、脳溝ピット解析(sulcal pit and pattern analysis:Im K and Grant PE.NeuroImage2017)を症例毎に解析を施行した。
    本研究の目的は、2つのコホートを用いて、ヒト早産児の多様な脳溝パターンと多彩な神経発達症との関係を主に6歳時データから明らかにすること、さらに、特異な中心溝形成をもつ超早産児の臨床像と運動・感覚野の機能を神経心理学的あるいは神経画像の両面から明らかにすることである。
    このうち、初年度は6歳時の頭部MRI構造画像データを解析し、神経症状との関係を明らかにすることが目標であった。
    現在までに、私たちは6歳の構造画像から脳各領域の体積や脳表面積を計測し、神経心理学的評価バッテリーとの相関解析を施行できている。一方で、集団画像解析が計画より遅れて進行中であり、次年度に達成する予定で調整中である。
    1.コホートAの新生期と1歳半のMRIを用いた脳溝パターンと周産期因子との関係を明らかにする。コホートAの修正40週(新生児期)および1歳半で施行された構造MRIは約100~120例である。脳溝画像は、昨年度と同様の手法を用い解析し、周産期因子(低栄養、感染・炎症、慢性肺障害、各種薬剤など)と脳溝パターンの関係を明らかにする。
    2.「特異な中心溝」を呈する児に対する機能解析
    6歳時MRIの脳溝解析の結果から、特異な中心溝パターンを認める症例に対し、詳細な神経心理学的評価、利き手、微細運動評価、機能的MRI(functional MRI)撮像を行う。過去の私達の検討から在胎30週以下の早産児の約10%に観察されると推定され、本研究では13~14名が研究対象者と見込まれる。機能的MRIは名古屋大学「脳とこころの研究センター」に設置された3テスラMRI機器を用いて、四肢、顔面、体幹の運動や感覚刺激課題に対するBOLD(Blood Oxygen Level Dependent)信号の変化に加え、安静時機能的MRIを撮像する。
    得られた脳画像を解析し、運動・感覚課題に対する脳領域を同定し、一次運動感覚野のマッピングを行う。また、安静時機能的MRIはFSL(FMRIB Software Library)、SPM(Statistical Parametric Mapping)などの脳画像解析のためのソフトウエアを使用し、感覚運動野ネットワークの変容の有無、異常な脳回・脳溝部位を関心領域としたネットワーク解析を行う。また、中心溝周囲の脳溝に与える影響を、グラフ理論を用いて解析する。

  4. Elucidation of altered neural network in the preterm brain based on spindle bursts in EEG, and its clinical regulation

    Grant number:17K10075  2017.4 - 2020.3

    Kidokoro Hiroyuki

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    During human brain development, spindles burst is a crucial spontaneous activity in EEG. The aim of this study was to elucidate the effect of the electrical activity on functional and structural brain development. We found that in extremely premature infants brushes corresponding to spindle bursts in animals occurred most frequently at 36 postmenstrual weeks. Additionally, the brush occurrence at 36 postmenstrual weeks was associated with white matter abnormality on brain MRI and in turn associated with neurodevelopmental outcomes at 18 months of corrected age. We also showed that functional and structural MRI reveals associations with neurodevelopment at 18 months of corrected age. These data indicated that brushes in EEG contribute to the altered brain development in preterm infants.

  5. From elderly person to children, evaluating development and aging from the viewpoint of functional MRI and physiological indicators

    Grant number:16K10313  2016.4 - 2020.3

    Nakane Toshiki

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    Authorship:Coinvestigator(s) 

    We measured, analyzed, and evaluated the relationship between the data obtained from physiological indices such as heart rate variability and the neural activity calculated from brain functional images. Regarding heartbeat, it is a factor that causes imaging artifacts in daily clinical image examination, but this time we analyzed brain functional images in relation to the aspect of the autonomic nervous system calculated from it. It was observed that resting brain activity formed networks known as the default mode network. The relationship with heart rate is currently under investifation.

  6. simultaneous EEG-fMRI analysis in West syndrome

    Grant number:16K09987  2016.4 - 2019.3

    Natsume Jun

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    Authorship:Coinvestigator(s) 

    We examined 7 patients with West syndrome (6 patients with cryptogenic West syndrome and 1 with tuberous sclerosis complex) by EEG-fMRI at the onset of West syndrome before ACTH therapy. The temporal information of periodic hypsarrhythmia was used to perform event-related analysis for detecting hypsarrhythmia-related blood oxygenation level-dependent (BOLD) changes on fMRI. As a result, positive BOLD changes were seen in brainstem and multiple cerebral cortices in 6 of 7 patients. After ACTH therapy epileptic spasms disappeared in all patients. However spasms relapsed in 2 patients and focal seizures were seen in 2. At 12 months of age, 3 patients had focal epileptiform discharges. EEG-fMRI at 12 months of age in these 3 patients revealed bilateral frontal positive BOLD in 2 patients and left hippocampal positive BOLD in 1. Positive BIOLD signal in the brainstem disappeared at 12 months of age in all 3 patients.

  7. Functional analysis of fetal acetylcholine receptor in patients with Escobar syndrome

    Grant number:16K19639  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Nakata Tomohiko, NATSUME jun, KIDOKORO hiroyuki, OHNO kinji, ITHO mikako, MIZUNO seiji, Engel Andrew G., Shen Xin-Ming

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    The nonlethal Escobar syndrome is caused by mutation in the CHRNG gene, which encodes the fetal gamma subunit of the acetylcholine receptor. We performed sequencing of CHRNG for patients with multiple joint contractures and found heterozygous mutations including one missense mutation in three patients from two families. We described clinical features and studied functional analysis using culture cells for the missense mutation. Although the clinical features of Escobar syndrome are variable but the condition is characterized by pterygia, all three patients had very mild pterygia. We conducted expression experiments and channel functional analyses using culture cells. We revealed that the mutation cause the fetal fast channel syndrome with abnormally brief opening and activity of the channel.

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Teaching Experience (On-campus) 1

  1. 小児神経学

    2014

 

Academic Activities 2

  1. ILAE_virtual academy 2021

    Role(s):Panel moderator, session chair, etc.

    2021.4

  2. ILAE virtual epilepsy academy 2020

    Role(s):Panel moderator, session chair, etc.

    2020.5

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    Type:Academic society, research group, etc. 

    File: PEEG_9 Course schedule 2020.pdf