研究者詳細 - 清水　一憲

論文 - 清水　一憲

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Open-Chamber Co-Culture Microdevices for Single-Cell Analysis of Skeletal Muscle Myotubes and Motor Neurons with Neuromuscular Junctions

Yamaoka Nao, Shimizu Kazunori, Imaizumi Yu, Ito Takuji, Okada Yohei, Honda Hiroyuki

BIOCHIP JOURNAL 13 巻 ( 2 ) 頁： 127-132 2019年6月

Regulation of the Distribution of Cells in Mixed Spheroids by Altering Migration Direction

Mizukami Yuya, Takahashi Yuki, Shimizu Kazunori, Konishi Satoshi, Takakura Yoshinobu, Nishikawa Maikiya

TISSUE ENGINEERING PART A 25 巻 ( 5-6 ) 頁： 390-398 2019年3月

Searching for high-binding peptides to bile acid for inhibition of intestinal cholesterol absorption using principal component analysis.

Ito M, Shimizu K, Honda H

Journal of bioscience and bioengineering 127 巻 ( 3 ) 頁： 366-371 2019年3月

Regulation of the Distribution of Cells in Mixed Spheroids by Altering Migration Direction.

Mizukami Y, Takahashi Y, Shimizu K, Konishi S, Takakura Y, Nishikawa M

Tissue engineering. Part A 25 巻 ( 5-6 ) 頁： 390-398 2019年3月

Searching for high-binding peptides to bile acid for inhibition of intestinal cholesterol absorption using principal component analysis

Ito Masako, Shimizu Kazunori, Honda Hiroyuki

JOURNAL OF BIOSCIENCE AND BIOENGINEERING 127 巻 ( 3 ) 頁： 366-371 2019年3月

Selective Elimination of Bitter Peptides by Adsorption to Heat-treated Porous Silica Gel 査読有り

Imai, K, Ikeda, A, Shimizu, K, Honda, H

Food Science and Technology Research 25 巻 ( 2 ) 頁： 179-186 - 186 2019年

Pep-MS assay: Protease hydrolysis assay system using photo-cleavable peptide array and mass spectrometer 査読有り

Kurimoto, M, Shimizu, K, Ochi, H, Abe, F, Honda, H

Journal of Bioscience and Bioengineering 128 巻 ( 2 ) 頁： 156-161 - 161 2019年

Predictive selection and evaluation of appropriate functional peptides for intestinal delivery with a porous silica gel 査読有り

Imai, K, Shimizu, K, Honda, H

Journal of Bioscience and Bioengineering 128 巻 ( 1 ) 頁： 44-49 - 49 2019年

Pep-MS assay: Protease hydrolysis assay system using photo-cleavable peptide array and mass spectrometer 査読有り

Kurimoto, M., Shimizu, K., Ochi, H., Abe, F., Honda, H.

Journal of Bioscience and Bioengineering 128 巻 ( 2 ) 頁： 156-161 2019年

Predictive selection and evaluation of appropriate functional peptides for intestinal delivery with a porous silica gel 査読有り

Imai, K., Shimizu, K., Honda, H.

Journal of Bioscience and Bioengineering 128 巻 ( 1 ) 頁： 44-49 2019年

Selective Elimination of Bitter Peptides by Adsorption to Heat-treated Porous Silica Gel 査読有り

Imai, K., Ikeda, A., Shimizu, K., Honda, H.

Food Science and Technology Research 25 巻 ( 2 ) 頁： 179-186 2019年

In-process evaluation of culture errors using morphology-based image analysis

Imai Yuta, Yoshida Kei, Matsumoto Megumi, Okada Mai, Kanie Kei, Shimizu Kazunori, Honda Hiroyuki, Kato Ryuji

REGENERATIVE THERAPY 9 巻頁： 15-23 2018年12月

Selective Elimination of Human Induced Pluripotent Stem Cells Using Medium with High Concentration of L-Alanine

Nagashima Takunori, Shimizu Kazunori, Matsumoto Ryo, Honda Hiroyuki

SCIENTIFIC REPORTS 8 巻 2018年8月

Interaction between porous silica gel microcarriers and peptides for oral administration of functional peptides

Imai Kento, Shimizu Kazunori, Kamimura Mitsuhiro, Honda Hiroyuki

SCIENTIFIC REPORTS 8 巻 2018年7月

Determining Transgene Expression Characteristics Using a Suction Device with Multiple Hole Adjusting a Left Lateral Lobe of the Mouse Liver

Haraguchi Ayana, Fuchigami Yuki, Kawaguchi Maho, Fumoto Shintaro, Ohyama Kaname, Shimizu Kazunori, Hagimori Masayori, Kawakami Shigeru

BIOLOGICAL & PHARMACEUTICAL BULLETIN 41 巻 ( 6 ) 頁： 944-950 2018年6月

Determining Transgene Expression Characteristics Using a Suction Device with Multiple Hole Adjusting a Left Lateral Lobe of the Mouse Liver

Haraguchi Ayana, Fuchigami Yuki, Kawaguchi Maho, Fumoto Shintaro, Ohyama Kaname, Shimizu Kazunori, Hagimori Masayori, Kawakami Shigeru

BIOLOGICAL & PHARMACEUTICAL BULLETIN 41 巻 ( 6 ) 頁： 944-950 2018年6月

Mutations responsible for alcohol tolerance in the mutant of Synechococcus elongatus PCC 7942 (SY1043) obtained by single-cell screening system

Hirokawa Yasutaka, Kanesaki Yu, Arai Sayuri, Saruta Fumiko, Hayashihara Kayoko, Murakami Akio, Shimizu Kazunori, Honda Hiroyuki, Yoshikawa Hirofumi, Hanai Taizo

JOURNAL OF BIOSCIENCE AND BIOENGINEERING 125 巻 ( 5 ) 頁： 572-577 2018年5月

Control of polarization and tumoricidal activity of macrophages by multicellular spheroid formation

Tanaka Yutaro, Nishikawa Makiya, Mizukami Yuya, Kusamori Kosuke, Ogino Yuka, Nishimura Shunsuke, Shimizu Kazunori, Konishi Satoshi, Takahashi Yuki, Takakura Yoshinobu

JOURNAL OF CONTROLLED RELEASE 270 巻頁： 177-183 2018年1月

Determining Transgene Expression Characteristics Using a Suction Device with Multiple Hole Adjusting a Left Lateral Lobe of the Mouse Liver.

Haraguchi A, Fuchigami Y, Kawaguchi M, Fumoto S, Ohyama K, Shimizu K, Hagimori M, Kawakami S

Biological & pharmaceutical bulletin 41 巻 ( 6 ) 頁： 944 - 950 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Biological and Pharmaceutical Bulletin

We developed a tissue suction-mediated transfection method (suction method) as a relatively reliable and less invasive technique for in vivo transfection. In this study, we determined hepatic transgene expression characteristics in the mouse liver, using a suction device, collecting information relevant to gene therapy and gene functional analysis by the liver suction method. To achieve high transgene expression levels, we developed a suction device with four holes (multiple hole device) and applied it to the larger portion of the left lateral lobe of the mouse liver. Hepatic transfection with physical stimuli was potentially controlled by activator protein-1 (AP-1) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). We examined the spatial distribution of transgene expression in the suctioned lobe by 2-dimensional imaging with histo-chemical staining and 3-dimensional multicolor deep imaging with tissue clearing methods. Through monitoring spatial distribution of transgene expression, the liver suction method was used to efficiently transfect extravascular hepatocytes in the suction-deformable upper lobe of the liver. Moreover, long-term transgene expression, at least 14d, was achieved with the liver suction method when cytosine-phosphate-guanine (CpG)-free plasmid DNA was applied.

DOI： 10.1248/bpb.b18-00094

Scopus

PubMed

Characterization of transgene expression and pDNA distribution of the suctioned kidney in mice.

Oyama N, Fuchigami Y, Fumoto S, Sato M, Hagimori M, Shimizu K, Kawakami S

Drug delivery 24 巻 ( 1 ) 頁： 906-917 2017年11月

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