Updated on 2022/07/05

写真a

 
NAKAGAWA Yu
 
Organization
Institute for Glyco-core Research Associate professor
Graduate School of Bioagricultural Sciences Associate professor
Graduate School
Graduate School of Bioagricultural Sciences
Title
Associate professor

Degree 1

  1. 博士(農学) ( 2002.3   京都大学 ) 

Research Interests 4

  1. medicinal chemistry

  2. supramolecular chemistry

  3. carbohydrate chemistry

  4. natural product chemistry

Research Areas 1

  1. Life Science / Bioorganic chemistry  / Natural Product Chemistry

Current Research Project and SDGs 2

  1. Development of glycan-binding molecules based on carbohydrate recognition by natural products

  2. Screening of new natural products with mannose-binding ability

Research History 6

  1. (独)理化学研究所 専任研究員(伊藤幸成研究室)

    2010.4 - 2014.4

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    Country:Japan

  2. (独)理化学研究所 研究員(伊藤幸成研究室)

    2008.11 - 2010.3

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    Country:Japan

  3. 京都大学大学院農学研究科 博士研究員(入江一浩研究室)

    2006.5 - 2008.10

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    Country:Japan

  4. 米国スタンフォード大学化学科 博士研究員 (P. A. Wender研究室)

    2005.4 - 2006.3

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    Country:United States

  5. 平成14年度日本学術振興会特別研究員 (PD, 京都大学)

    2002.4 - 2005.3

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    Country:Japan

  6. 平成11年度日本学術振興会特別研究員 (DC1, 京都大学)

    1999.4 - 2002.3

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    Country:Japan

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Education 3

  1. Kyoto University   Graduate School, Division of Agriculture

    1999.4 - 2002.3

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    Country: Japan

  2. Kyoto University   Graduate School, Division of Agriculture

    1997.4 - 1999.3

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    Country: Japan

  3. Kyoto University   Faculty of Agriculture

    1993.4 - 1997.3

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    Country: Japan

Professional Memberships 3

  1. 日本農芸化学会   会員

  2. 日本糖質学会   会員

  3. 有機合成化学協会   会員

Committee Memberships 5

  1. 日本糖質学会   評議員  

    2017.7   

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    Committee type:Academic society

  2. 日本農芸化学会中部支部   庶務幹事  

    2018.4 - 2020.3   

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    Committee type:Academic society

  3. 日本農芸化学会2018年度大会   大会実行委員(会計)  

    2018   

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    Committee type:Academic society

  4. 第38回日本糖質学会年会   組織委員  

    2020.11   

  5. 第62回天然有機化合物討論会   プログラム編成委員  

    2020.9   

Awards 3

  1. 日本農芸化学会2019年度大会トピックス賞

    2019.3   日本農芸化学会   糖結合性天然色素の二量体を用いた真菌の染色

    田浦寛太,小鹿一,五十嵐康弘,伊藤幸成,中川優

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  2. 農芸化学奨励賞

    2011.5   日本農芸化学会  

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    Country:Japan

  3. 第9回天然物化学談話会奨励賞

    2009.7   天然物化学談話会  

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    Country:Japan

 

Papers 55

  1. Mannose-binding analysis and biological application of pradimicins Invited Reviewed

    Yu Nakagawa, Yukishige Ito

    Proceedings of the Japan Academy, Series B   Vol. 98 ( 1 ) page: 15 - 29   2022.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.2183/pjab.98.002

  2. D-Mannose binding, aggregation property, and antifungal activity of amide derivatives of pradimicin A Reviewed

    Wataru Miyanishi, Makoto Ojika, Dai Akase, Misako Aida, Yasuhiro Igarashi, Yukishige Ito, Yu Nakagawa

    Bioorganic & Medicinal Chemistry   Vol. 55   page: 116590   2021.12

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1016/j.bmc.2021.116590

  3. A pradimicin-based staining dye for glycoprotein detection Reviewed

    Yu Nakagawa, Shintaro Kakihara, Kazue Tsuzuki, Makoto Ojika, Yasuhiro Igarashi, Yukishige Ito

    Journal of Natural Products   Vol. 84 ( 9 ) page: 2496 - 2501   2021.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1021/acs.jnatprod.1c00506

  4. Binding Evaluation of Pradimicins for Oligomannose Motifs from Fungal Mannans Reviewed

    Bulletin of the Chemical Society of Japan   Vol. 94 ( 3 ) page: 732 - 754   2020.12

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  5. Paving the way for practical use of sugar-binding natural products as lectin mimics in glycobiological research Invited Reviewed

    ChemBioChem   Vol. 21   page: 1567 - 1572   2020.3

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  6. Relationship among structure, cytotoxicity, and Michael acceptor reactivity of quinocidin Reviewed

    Nakagawa, Y., Sawaki, Y., Miyanishi, W., Shimomura, S., Shibata, T., Ojika, M.

    Bioorganic & Medicinal Chemistry   Vol. 28   page: 115308   2020.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  7. The endocyclic oxygen atom of D-mannopyranose is involved in its binding to pradimicins Reviewed

    Watanabe, Y., Yamaji, F., Ojika, M., Sugawara, T., Akase, D., Aida, M., Igarashi, Y., Ito, Y., Nakagawa, Y.

    Tetrahedron Letters   Vol. 61   page: 151530   2019.12

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  8. Molecular Basis of Mannose Recognition by Pradimicins and Their Application to Microbial Cell Surface Imaging Reviewed

    Nakagawa, Y., Doi, T., Takegoshi, K., Sugahara, T., Akase, D., Aida, M., Tsuzuki, K., Watanabe, Y., Tomura, T., Ojika, M., Igarashi, Y., Hashizume, D., Ito, Y.

    Cell Chemical Biology   Vol. 26   page: 950 - 959   2019.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  9. Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin Reviewed

    Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S., Irie, K.

    Heterocycles   Vol. 97 ( 1 ) page: 478-492   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  10. Quinocidin, a Cytotoxic Antibiotic with an Unusual 3,4-Dihydroquinolizinium Ring and Michael Acceptor Reactivity toward Thiols Reviewed

    Nakagawa Yu, Sawaki Yuki, Kimura Takahiro, Tomura Tomohiko, Igarashi Yasuhiro, Ojika Makoto

    CHEMISTRY-A EUROPEAN JOURNAL   Vol. 23 ( 71 ) page: 17894-17897   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chem.201704729

    Web of Science

    PubMed

  11. Solid-State Nuclear Magnetic Resonance Analysis Reveals a Possible Calcium Binding Site of Pradimicin A Reviewed

    Doi Takashi, Nakagawa Yu, Takegoshi K.

    BIOCHEMISTRY   Vol. 56 ( 3 ) page: 468-472   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.biochem.6b01300

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  12. Solid-State NMR Analysis of Mannose Recognition by Pradimicin A

    Nakagawa Yu, Ito Yukishige

    NMR IN GLYCOSCIENCE AND GLYCOTECHNOLOGY   Vol. 10   page: 269-289   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  13. Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway Reviewed

    Staveness, D., Abdelnabi, R., Near, K. E., Nakagawa, Y., Neyts, J., Delang, L., Leyssen, P., Wender, P. A.

    Journal of Natural Products     page: 10.1021/acs.jnatprod.5b01017   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.jnatprod.5b01017

  14. Pradimicin A, a D-mannose-binding antibiotic, binds pyranosides of L-fucose and L-galactose in a calcium-sensitive manner Reviewed

    Nakagawa, Y., Watanabe, Y., Igarashi, Y., Ito, Y., Ojika, M.

    Bioorg. Med. Chem. Lett.   Vol. 25 ( 15 ) page: 2963-2966   2015.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmcl.2015.05.021

  15. 天然物の構造単純化による有用分子の創製:天然プロテインキナーゼC活性化剤のアナログ設計 Reviewed

    中川 優

    有機合成化学協会誌   Vol. 73 ( 4 ) page: 316-327   2015.4

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  16. Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs Reviewed

    Wender, P. A., Nakagawa, Y., Near, K. E., Staveness, D.

    Org. Lett.   Vol. 16   page: 5136-5139   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

  17. 第3の生命鎖・糖鎖に結合する低分子化合物に関する現状と展望 Invited Reviewed

    中川 優

    ファルマシア   Vol. 50 ( 11 ) page: 1117-1122   2014

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    Authorship:Lead author   Language:Japanese  

  18. Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity Reviewed

    Kamachi, H., Tanaka, K., Yanagita, R. C., Murakami, A., Murakami, K., Tokuda, H., Suzuki, N., Nakagawa, Y., and Irie, K.

    Bioorg. Med. Chem.   Vol. 21   page: 2695-2702   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

  19. Mannose binding geometry of pradimicin A Reviewed

    Nakagawa, Y., Doi, T., Taketani, T., Takegoshi, K., Igarashi, Y., and Ito, Y.

    Chem. Eur. J.   Vol. 19   page: 10516-10525   2013

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  20. Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues Reviewed

    Sato, M., Murakami, K., Uno, M., Ikubo, H., Nakagawa, Y., Katayama, S., Akagi, H., Masuda, Y., Takegoshi, K. and Irie, K.

    J. Biol. Chem.   Vol. 288   page: 23212-23224   2013

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  21. Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid beta aggregation Reviewed

    Sato, M., Murakami, K., Uno, M., Ikubo, H., Nakagawa, Y., Katayama, S., Akagi, H., and Irie, K.

    Biosci. Biotechnol. Biochem.   Vol. 77   page: 1100-1103   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

  22. Solid-state NMR analysis of calcium and D-mannose binding of BMY-28864, a water-soluble analogue of pradimicin A Reviewed

    Nakagawa, Y., Doi, T., Takegoshi, K., Igarashi, Y., and Ito, Y.

    Bioorg. Med. Chem. Lett.   Vol. 22   page: 1040-1043   2012

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  23. Molecular architecture and therapeutic potential of lectin mimics Invited Reviewed

    Nakagawa, Y. and Ito, Y.

    Advances in Carbohydrate Chemistry and Biochemistry     page: 1-58   2012

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  24. Artificial analogs of naturally occurring tumor promoters as biochemical tools and therapeutic leads Invited Reviewed

    Nakagawa, Y.

    Biosci. Biotechnol. Biochem.   Vol. 76   page: 1262-1274   2012

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  25. Carbohydrate-binding molecules with non-peptidic skeletons Invited Reviewed

    Nakagawa, Y. and Ito, Y.

    Trends Glycosci. Glycotechnol.   Vol. 24   page: 1-12   2012

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  26. Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1 Invited Reviewed

    Irie, K., Kikumori, M., Kamachi, H., Tanaka, K., Murakami, A., Yanagita, R. C., Tokuda, H., Suzuki, N., Nagai, H., Suenaga, K., and Nakagawa, Y.

    Pure Appl. Chem.   Vol. 84   page: 1341-1351   2012

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  27. Challenges to the Development of Bryostatin-type Anticancer Drugs Based on the Activation Mechanism of Protein Kinase Cδ Invited Reviewed

    Irie, K., Yanagita, R. C., and Nakagawa, Y.

    Med. Res. Rev.   Vol. 32   page: 518-535   2012

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  28. Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin Reviewed

    Nakagawa, Y., Kikumori, M., Yanagita, R. C., Murakami, A., Tokuda, H., Nagai, H. and Irie, K.

    Biosci. Biotechnol. Biochem.   Vol. 75   page: 1167-1173   2011

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  29. Mapping of the Primary Mannose-Binding Site of Pradimicin A Reviewed

    Nakagawa, Y., Doi, T., Masuda, Y., Takegoshi, K., Igarashi, Y., and Ito, Y.

    J. Am. Chem. Soc.   Vol. 133   page: 17485-17493   2011

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  30. Solid-state NMR Spectroscopic Analysis of the Ca2+-dependent Mannose Binding of Pradimicin A Reviewed

    Nakagawa, Y., Masuda, Y., Yamada, K., Doi, T., Takegoshi, K., Igarashi, Y., and Ito, Y.

    Angew. Chem. Int. Ed.   Vol. 50   page: 6084-6088   2011

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  31. Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity Reviewed

    Yanagita, R. C., Kamachi, H., Tanaka, K., Murakami, A., Nakagawa, Y., Tokuda, H., Nagai, H., and Irie, K.

    Bioorg. Med. Chem. Lett.   Vol. 20   page: 6064-6066   2010

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  32. A Simple Analog of Tumor-promoting Aplysiatoxin Is an Antineoplastic Agent Rather Than a Tumor Promoter: Development of a Synthetically Accessible PKC Activator with Bryostatin-like Activity Reviewed

    Nakagawa, Y., Yanagita, R. C., Hamada, N., Murakami, A., Takahashi, H., Saito, N., Nagai, H. and Irie, K.

    J. Am. Chem. Soc.   Vol. 131   page: 7573-7579   2009

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  33. Synthesis, Conformational Analysis, and Biological Evaluation of 1-Hexyl-indolactam-V10 as a Selective Activator for Novel Protein Kinase C Isozymes Reviewed

    Yanagita, R. C., Nakagawa, Y., Yamanaka, N., Kashiwagi, K., Saito, N. and Irie, K.

    J. Med. Chem.   Vol. 51   page: 46-56   2008

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  34. Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes Reviewed

    Yanagita, R. C., Torii, K., Nakagawa, Y. and Irie, K.

    Heterocycles   Vol. 73   page: 289-302   2007

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  35. Design and Synthesis of 8-Octyl-benzolactam-V9, the selective activator for PKCε and η Reviewed

    Nakagawa, Y., Irie, K., Yanagita, R. C., Ohigashi, H., Tsuda, K., Kashiwagi, K. and Saito, N.

    J. Med. Chem.   Vol. 49   page: 2681-2688   2006

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  36. Indolactam-V is involved in the CH/π Interaction with Pro-11 of PKCδ C1B domain: Application to Structural Optimization for PKCδ Ligand Reviewed

    Nakagawa, Y., Irie, K., Yanagita, C. R., Ohigashi, H. and Tsuda, K.

    J. Am. Chem. Soc.   Vol. 127   page: 5746-5747   2005

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  37. Toward the Development of New Medicinal Leads with Selectivity for Protein Kinase C Isozymes Invited Reviewed

    Irie, K., Nakagawa, Y. and Ohigashi, H.

    Chem. Rec.   Vol. 5   page: 185-195   2005

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  38. Synthesis, Conformation and PKC isozyme Surrogate Binding of Indolinelactam-Vs, New Conformationally-Restricted Analogues of (-)-Indolactam-V Reviewed

    Nakagawa, Y., Irie, K., Komiya, Y., Ohigashi, H. and Tsuda, K.

    Tetrahedron   Vol. 60   page: 7077-7084   2004

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  39. Indolactam and Benzolactam Compounds as New Medical Leads with Binding Selectivity for C1 Domains of Protein Kinase C Isozymes Invited Reviewed

    Irie, K., Nakagawa, Y. and Ohigashi, H.

    Curr. Pharm. Design   Vol. 10   page: 1371-1385   2004

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  40. Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s Reviewed

    Irie, K., Masuda, A., Shindo, M., Nakagawa, Y. and Ohigashi, H.

    Bioorg. Med. Chem. Lett.   Vol. 12   page: 4547-4583   2004

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  41. Synthesis and Binding Selectivity of 7- and 15-Decylbenzolactone-V8 for the C1 Domains of Protein Kinase C Isozymes Reviewed

    Nakagawa, Y., Irie, K., Yamanaka, N., Ohigashi, H. and Tsuda, K.

    Bioorg. Med. Chem. Lett.   Vol. 13   page: 3015-3019   2003

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  42. Synthesis and PKC Isozyme Surrogate Binding of Lactone Analogues of Benzolactam-V8's Reviewed

    Nakagawa, Y., Irie, K., Masuda, A. and Ohigashi, H.

    Tetrahedron   Vol. 58   page: 2101-2115   2002

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  43. Establishment of a binding assay for new medicinal leads with protein kinase C isozyme and C1 domain selectivity Invited Reviewed

    Irie, K., Nakahara, A., Nakagawa, Y., Ohigashi, H., Shindo, M., Fukuda, H., Konishi, H., Kikkawa, U., Kashiwagi, K. and Saito, N.

    Pharmacol. Ther.   Vol. 93   page: 271-281   2002

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  44. Binding Selectivity of Conformationally Restricted Analogues of (-)-Indolactam-V to the C1 Domains of Protein Kinase C Isozymes Reviewed

    Masuda, A., Irie, K., Nakagawa, Y. and Ohigashi, H.

    Biosci. Biotechnol. Biochem.   Vol. 66   page: 1615-1617   2002

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  45. The C4 Hydroxyl Group of Phorbol Esters is Not Necessary for Protein Kinase C Binding Reviewed

    Tanaka, M., Irie, K., Nakagawa, Y., Nakamura, Y., Ohigashi, H. and Wender, P. A.

    Bioorg. Med. Chem. Lett.   Vol. 11   page: 719-722   2001

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  46. The Amide Hydrogen of (-)-Indolactam-V and Benzolactam-V8's Plays a Critical Role in Protein Kinase C Binding and Tumor-promoting Activities Reviewed

    Nakagawa, Y., Irie, K., Nakamura, Y. and Ohigashi, H.

    Bioorg. Med. Chem. Lett.   Vol. 11   page: 723-728   2001

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  47. Synthesis and Tumor-promoting Activities of 12-Epi-phorbol-12,13-dibutyrate Reviewed

    Irie, K., Nakahara, A., Ikawa, Y., Tanaka, M., Nakagawa, Y., Nakamura, Y., Ohigashi, H. and Wender, P. A.

    Biosci. Biotechnol. Biochem.   Vol. 64   page: 2429-2436   2000

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  48. Selective Binding of Tumor Promoters to the Novel PKC C1B Domains Invited Reviewed

    Irie, K., Nakahara, A., Nakagawa, Y., Ohigashi, H., Shindo, M., Fukuda, H., Konishi, H. and Kikkawa, U.

    Peptide Science 2000     page: 197-200   2000

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  49. Selective Binding to the nPKC C1B Domains by Tumor Promoters

    Nakagawa, Y. and Irie, K.

    Bioscience & Industry   Vol. 58   page: 570-571   2000

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  50. Synthesis and PKC Isozyme Surrogate Binding of Indothiolactam-V, a New Thioamide Analogue of Tumor Promoting Indolactam-V Reviewed

    Nakagawa, Y., Irie, K., Ohigashi, H., Hayashi, H. and Wender, P. A.

    Bioorg. Med. Chem. Lett.   Vol. 10   page: 2087-2090   2000

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  51. Isolation of (-)-14-O-Malonylindolactam-V as a Possible Precursor of (-)-Indolactam-V and (-)-14-O-Acetylindolactam-V from Streptomyces blastmyceticum Reviewed

    Irie, K., Tomimatsu, S., Nakagawa, Y., Ohigashi, H. and Hayashi, H.

    Biosci. Biotechnol. Biochem.   Vol. 63   page: 1669-1670   1999

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  52. Synthesis and Biological Activities of (-)-6-n-Octyl-indolactam-V, a New Potent Analogue of the Tumor Promoter (-)-Indolactam-V Reviewed

    Nakagawa, Y., Irie, K., Nakamura, Y. and Ohigashi, H.

    Biosci. Biotechnol. Biochem.   Vol. 62   page: 1568-1573   1998

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  53. Biosynthesis of Monoterpenoid Moiety of Teleocidins via the Non-mevalonate Pathway in Streptomyces Reviewed

    Irie, K., Nakagawa, Y., Tomimatsu, S. and Ohigashi, H.

    Tetrahedron Lett.   Vol. 39   page: 7929-7930   1998

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  54. Synthesis and Biological Activities of Indolactone-V, the Lactone Analogue of the Tumor Promoter (-)-Indolactam-V Reviewed

    Nakagawa, Y., Irie, K., Nakamura, Y., Ohigashi, H. and Hayashi, H.

    Biosci. Biotech. Biochem.   Vol. 61   page: 1415-1417   1997

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  55. Comparison of Chemical Characteristics of the First and Second Cystein-Rich Domains of Protein Kinase Cγ Reviewed

    Irie, K., Yanai, Y., Oie, K., Ishizawa, J., Nakagawa, Y., Ohigashi, H., Wender, P. A. and Kikkawa, U.

    Bioorg. Med. Chem.   Vol. 5   page: 1725-1737   1997

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Books 1

  1. Solid-state NMR Analysis of Mannose Recognition by Pradimicin A

    Nakagawa, Y.; Ito, Y.( Role: Joint author)

    Royal Society of Chemistry  2017  ( ISBN:978-1-78262-310-6

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    Total pages:458   Language:English Book type:Scholarly book

Presentations 22

  1. プラディミシンと複合型糖鎖との相互作用の化学的検証

    藤井将人,小鹿 一,五十嵐康弘,伊藤幸成,中川 優

    日本農芸化学会2022年度大会  2022.3.17  日本農芸化学会

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都  

  2. プラディミシンAの非凝集性アジド含有誘導体の開発

    音田昴志,小鹿 一,五十嵐康弘,伊藤幸成,中川 優

    日本農芸化学会2022年度大会  2022.3.17  日本農芸化学会

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都  

  3. 糖結合性天然物プラディミシンの低凝集性誘導体の開発

    音田昴志,小鹿 一,五十嵐康弘,伊藤幸成,中川 優

    糖鎖科学中部拠点 第17回若手の力フォーラム  2022.1.13  糖鎖科学中部拠点

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    Event date: 2022.1

    Language:Japanese   Presentation type:Oral presentation (general)  

  4. O-マンノシル化タンパク質検出ツールの開発に向けたプラディミシンの誘導体化

    音田昴志,小鹿 一,五十嵐康弘,伊藤幸成,中川 優

    第40回日本糖質学会年会  2022.10.29  日本糖質学会

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    Event date: 2021.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:鹿児島  

  5. プラディミシンと複合型糖鎖の相互作用解析

    藤井将人,小鹿 一,五十嵐康弘,伊藤幸成,中川 優

    第40回日本糖質学会年会  2021.10.27  日本糖質学会

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    Event date: 2021.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:鹿児島  

  6. アミド化したプラディミシン誘導体の凝集性とマンノース結合活性

    大矢柚香、小鹿 一、五十嵐康弘、伊藤幸成、中川 優

    日本農芸化学会2021年度大会  日本農芸化学会

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    Event date: 2021.3

    Language:Japanese  

    Venue:仙台  

  7. O-マンノシル化セリン/スレオニンに対するプラディミシンAの結合評価

    音田昴志、小鹿 一、五十嵐康弘、伊藤幸成、中川 優

    日本農芸化学会2021年度大会  日本農芸化学会

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    Event date: 2021.3

    Language:Japanese  

    Venue:仙台  

  8. 不可逆的阻害剤への応用に向けた3,4-dihydroquinolizinium化合物の開発

    川合計太朗、小鹿 一、中川 優、

    日本農芸化学会2021年度大会  日本農芸化学会

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    Event date: 2021.3

    Language:Japanese  

    Venue:仙台  

  9. Pradimicinアミド誘導体の設計と糖タンパク質検出への応用

    垣原眞太朗、宮西 航、小鹿 一、五十嵐康弘、伊藤幸成、中川 優

    糖鎖科学中部拠点 第16回若手の力フォーラム  2021.1.22  糖鎖科学中部拠点

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    Event date: 2021.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋  

  10. 3,4-Dihydroquinolizinium化合物の合成とチオールに対する反応性評価

    川合計太朗、小鹿 一、中川 優

    日本農芸化学会中部支部 第187回例会  2020.9.26  日本農芸化学会中部支部

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋  

  11. Pradimicin Aのアミド誘導体を利用した糖タンパク質の染色

    垣原眞太朗、宮西 航、小鹿 一、五十嵐康弘、伊藤幸成、中川 優

    第62回天然有機化合物討論会  2020.9.22  日本化学会、日本薬学会、日本農芸化学会

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    Event date: 2020.9

    Venue:名古屋  

  12. マンノースに結合する天然物の糖認識機構解析〜糖鎖生物学研究への応用を目指して〜 Invited International conference

    中川優

    香川大学農学部応用生命化学研究センター第10回公開シンポジウム 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Country:Japan  

  13. 天然物研究における微生物の利用法 Invited

    中川 優

    第5回糸状菌分子生物学若手の会 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:佐賀   Country:Japan  

  14. マンノース結合性天然物の糖認識機構解析:糖鎖研究への利用を目指して Invited

    中川 優

    理研シンポジウム 小胞体糖修飾の統合的ケミカルバイオロジー 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:理化学研究所   Country:Japan  

  15. プラディミシンはいかに糖を認識しているか? Invited

    中川優

    第3回天然物化学研究会 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京農業大学   Country:Japan  

  16. 天然物低分子化合物による糖鎖認識の機構解析

    中川 優

    新学術領域研究「天然物ケミカルバイオロジー:分子標的と活性制御」第六回公開シンポジウム 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  17. Geometry of the Primary Mannose Binding of Pradimicin A

    3. Yu Nakagawa, Takashi Doi, Takara Taketani, Kiyonori Takegoshi, Yasuhiro Igarashi, Yukishige Ito

    The 8th International Conference on Cutting-Edge Organic Chemistry 

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    Event date: 2013.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  18. Solid-state NMR analysis of mannose binding of pradimicin A

    Yu Nakagawa, Takashi Doi, Takara Taketani, Kiyonori Takegoshi, Yasuhiro Igarashi, Yukishige Ito

    The 1st Asian Conference for "MONODUKURI" Strategy by Synthetic Organic Chemistry 

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    Event date: 2013.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  19. 天然発がんプロモーター研究の新展開

    中川 優

    日本農芸化学会関東支部2011年度第2回支部例会 

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    Event date: 2012.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  20. 特異な誘導体が拓く新しい天然発がんプロモーター研究

    中川 優

    第63回白鷺セミナー 

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    Event date: 2011.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  21. 天然発がんプロモーターの骨格を有する抗がん剤リードの創製と作用機構解析

    中川 優

    第45回 天然物化学談話会 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  22. 天然発がんプロモーターの骨格を有する新奇抗がん剤の開発

    中川 優

    第44回 天然物化学談話会 

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    Event date: 2009.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 1

  1. 天然低分子化合物の糖鎖認識機構に基づく糖鎖結合性ツール分子の開発

    2014.10 - 2017.3

    SUNBOR GRANT 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. 糖鎖を標的分子とした抗菌薬リードの創製

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  2. マンノース結合活性を有する新規天然物の探索

    2014.4 - 2017.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  3. タンパク質ドメインの鏡像体を利用したマンノースレセプター設計の新戦略

    2012.4 - 2015.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  4. Pradimicinの標的糖鎖同定に基づく糖鎖結合性人工分子の設計開発

    2012.4 - 2014.3

    科学研究費補助金  新学術領域(研究領域提案型)(公募研究)

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    Authorship:Principal investigator 

  5. レクチン様天然物Pradimicinによる糖鎖認識機構の解析

    2010.4 - 2012.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

 

Teaching Experience (On-campus) 30

  1. 応用生命科学科実験実習

    2020

  2. 生物活性物質化学特論

    2020

  3. 応用生命科学科実験実習

    2019

  4. 生物活性物質化学特論

    2019

  5. Bioorganic Chemistry

    2019

  6. 生理活性物質化学

    2019

  7. 基礎セミナーA

    2019

  8. 生命農学序説

    2019

  9. 生物活性物質化学特論

    2018

  10. 応用生命科学科実験実習

    2018

  11. 生理活性物質化学

    2018

  12. 基礎セミナーA

    2018

  13. 生理活性物質化学

    2017

  14. 基礎セミナーA

    2017

  15. 生命機能化学特論

    2017

  16. 生命農学序論

    2017

  17. 応用生命科学科実験実習

    2017

  18. 基礎セミナーA

    2016

  19. 生理活性物質化学

    2016

  20. 応用生命科学科実験実習

    2016

  21. 生命機能化学特論

    2016

  22. 生命農学入門

    2016

  23. 基礎セミナーA

    2015

  24. 生理活性物質化学

    2015

  25. 応用生命科学科実験実習

    2015

  26. 生命機能化学特論

    2015

  27. 生命農学入門

    2015

  28. 生理活性物質化学

    2014

  29. 生命農学入門

    2014

  30. 生命機能化学特論

    2014

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Teaching Experience (Off-campus) 2

  1. Food Science and Biotechnology V

    2021.11 Kyoto University)

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    Level:Postgraduate 

  2. 糖鎖科学特論

    2017.11

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    Level:Postgraduate 

 

Social Contribution 3

  1. 名古屋大学魅力発見ブック

    Role(s):Media coverage

    河合塾  2020.6

  2. 糖鎖中部拠点 平成29年度糖鎖科学講義

    Role(s):Lecturer

    糖鎖中部拠点  2017.11

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    Audience: College students, Graduate students

    Type:Lecture

  3. スーパーサイエンスハイスクール研究室体験研修

    Role(s):Advisor

    2014.8

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    Audience: High school students

    Type:Research consultation