Language：English   Publishing type：Research paper (scientific journal)   Publisher：Sleep and Biological Rhythms  

Disruption of the circadian rhythm and sleep–wake cycles is a consequence of aging and is associated with the cognitive decline and many neurodegenerative conditions. We investigated the bedtime, wake-up time, sleep timing (midpoint between bedtime and wake-up time), and sleep timing standard deviation (SD) using the actigraphy among 80 consecutive volunteers aged ≥ 60 years. Global cognitive function and executive function of detailed cognitive domains were evaluated using the mini-mental state examination (MMSE) and Wisconsin card sorting test (WCST) and subjective daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS). The category achievement (CA), total errors (TE), perseverative errors of Nelson (PEN), non-perseverative errors (NPE), and difficulties in maintaining set (DMS) on the WCST were significantly correlated with sleep timing SD (CA: r = − 0.276, p = 0.013, TE: r = 0.311, p = 0.005, PEN: r = 0.241, p = 0.032, NPE: r = 0.250, p = 0.025, DMS: r = 0.235, p = 0.036), but not with the MMSE score. Multiple regression analyses with the stepwise forward selection method including age, ESS score, bedtime, sleep timing, and sleep timing SD, revealed that the ESS score, and sleep timing SD were significant factors related to CA on the WCST (ESS score: β = − 0.322, p = 0.004; sleep timing SD: β = − 0.250, p = 0.022). Assessment of sleep–wake rhythms, daytime sleepiness, and cognitive function using the MMSE and WCST is valuable for the prediction of cognitive decline in the geriatric population.

DOI： 10.1007/s41105-023-00491-z

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Sleep and Breathing  

Purpose: Patients with psychiatric disorders often complain of sleep disturbances and are frequently suspected of obstructive sleep apnea (OSA). However, data regarding sleep problems evaluated by attended polysomnography (PSG) remain limited in this population. We analyzed the results of attended PSG from psychiatric patients with sleep-related problems to determine the prevalence and features of sleep disorders among this population. Methods: We retrospectively investigated the attended PSG results of patients with psychiatric disorders: major depressive disorder, bipolar disorder, neurodevelopmental disorder, schizophrenia, neurocognitive disorder, anxiety disorder, somatic symptom disorder. Results: Of 264 patients, 158 men (60%), mean age was 47 ± 19.9 years. More than half of the patients with major depressive disorder (62%), bipolar disorder (70%), schizophrenia (58%), neurocognitive disorders (55%), and somatic symptom disorder (56%) had OSA. Among the psychiatric patients with OSA, 62% of these patients had moderate to severe OSA. The risk factors for OSA were snoring, male, age, and body mass index. The presence of OSA was not associated with the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale score, or benzodiazepine, antipsychotic, or antidepressant use. Other sleep disorders were insomnia (19%), central disorders of hypersomnia (8%), restless legs syndrome/periodic limb movement of sleep (8%), rapid eye movement sleep behavior disorder (7%), and central sleep apnea syndrome (3%). Conclusions: PSG revealed that moderate to severe OSA was common in psychiatric patients with or without snoring. Subjective symptoms and psychotropics did not predict OSA. Therefore, PSG is needed to reveal sleep conditions in patients with psychiatric disorders.

DOI： 10.1007/s11325-022-02566-6

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Sleep and Biological Rhythms  

Sleep problems and obstructive sleep apnea (OSA) increase with age and disturb life in old age. Positional therapy is one option to treat OSA, but the differences in clinical pathophysiology between elderly and other age groups have not been fully investigated. We explored the pathophysiological features of sleep apnea, factors that are independently associated with positional OSA and the prevalence in elderly patients. We studied demographic and polysomnographic data of 85 elderly individuals with OSA (age ≥ 65 years) and 124 non-elderly patients with OSA (age, 20–64 years). The Amsterdam Positional OSA Classification (APOC) was used to evaluate positional OSA. Body mass index (BMI) and Epworth sleepiness scale were both significantly lower in the elderly group than in the non-elderly group, although apnea/hypopnea index (AHI) did not differ between groups. OSA severity affected total sleep time, sleep efficiency, and waking after sleep onset more in the elderly than in the non-elderly. AHI in the lateral position was significantly lower in elderly than in non-elderly, although AHI in the supine position was almost the same between two groups. The distribution of APOC 1 and 2 (lateral sleep effective) was significantly higher in the elderly than in the non-elderly. Relative factors such as BMI, rate of hypopnea, and lowest SpO2 associated with positional OSA in non-elderly groups did not differ significantly among APOC subgroups in elderly patients. Our findings are suggesting that characteristics of the positional OSA is different between elderly and younger-age OSA patients.

DOI： 10.1007/s41105-022-00385-6

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Nature and Science of Sleep  

Purpose: Sleep state misperception, which is the discrepancy between subjective and objective sleep, is often observed in patients with depression. This phenomenon may delay the remission of depression. Previous studies have focused on the total sleep time (TST) misperception, with many of these studies using actigraphy. Thus, our study investigated depressed patients with the exploratory aim of clarifying factors associated with the sleep state misperception including the wake after sleep onset (WASO) misperception, with their objective sleep additionally evaluated by polysomnography (PSG). Patients and Methods: We conducted a cross-sectional study. Before undergoing overnight PSG monitoring, 40 patients with depression completed questionnaires that included the Beck Depression Inventory (BDI), Epworth sleepiness scale, Temperament and Character Inventory, and the Pittsburgh sleep quality index. Patients were also asked to estimate their subjective sleep duration after they woke up in the morning. Based on this data, we calculated the misperception using the following formula: subjective sleep duration minus objective sleep duration. We compared each factor between negative and positive misperception groups and the multiple regression analysis was performed for TST and WASO misperception, respectively. Results: Although sleep architectures, age, severity of depression and obstructive sleep apnea (OSA) exhibited differences in underestimating or overestimating the WASO, only sex differences were associated with underestimating or overestimating their total sleep time (TST). Moreover, BDI, the severity of OSA, sleep architectures (N1% and N2%), and benzodiazepine (BZD) use were significantly correlated with WASO misperception, whereas only OSA severity was significantly correlated with TST misperception. A subsequent multiple regression analysis demonstrated the BDI was independently correlated with the WASO misperception (β=0.341, p=0.049). Conclusion: In clinical practice, interventions especially for OSA, and the reduction of depressive symptoms are an important method for improving patient sleep perception. Moreover, current results suggest that BZD prescriptions should be avoided as well.

DOI： 10.2147/NSS.S366774

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：BMJ Open  

Introduction Bidirectional associations have been reported between sleep disturbance and both cognitive impairment, including Alzheimer’s disease and amyloid beta-peptide (Aβ) accumulation. These relationships can be explained by the glymphatic system, which acts as a garbage drainage system in the brain. As interstitial fluid dynamics are suggested to increase during sleep, clearance of Aβ can be influenced by sleep disturbance or deprivation. We hypothesised that using lemborexant, an orexin receptor antagonist, to improve sleep quality would also improve the function of the glymphatic system. We plan to examine the effect of lemborexant on sleep quality and the glymphatic system among patients with insomnia disorder. Methods and analysis This pilot study is designed as an open-label, single-arm, single-centre trial. Thirty patients aged 50 years and over with insomnia will be recruited. The participants will take lemborexant (5 mg) at bedtime for 12 weeks and undergo a home-based sleep study at baseline and weeks 4 and 12, as well as MRI examinations to evaluate the glymphatic system at baseline and week 12. The primary outcome will be changes in objective sleep parameters as evaluated using a sleep monitoring system. The secondary outcomes will be changes in subjective sleep parameters. The relationships between changes in sleep parameters and the glymphatic system will be evaluated using diffusion tensor image analysis along the perivascular space, which is called the ALPS-index. Sleep parameters and the ALPS-index will be analysed using a paired t-test or Pearson’s correlation coefficient. Ethics and dissemination The study protocol was approved by Nagoya University Certified Review Board. The findings from this research will be published in peer-reviewed journals and be presented at local, national and international conferences.

DOI： 10.1136/bmjopen-2021-054885

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Sleep Research  

Key clinical symptoms observed among individuals with psychiatric disorders include difficulty falling asleep or maintaining sleep, poor sleep quality and nightmares. Those suffering from sleep disorders often present with symptoms of discontent with regard to sleep quality, timing and quantity, and these symptoms have an adverse impact on function and quality of life. A minimally invasive technique would be preferable in patients with psychiatric disorders, who tend to be sensitive to environmental change. Accordingly, we evaluated the performance of Zmachine Insight Plus, an ambulatory electroencephalography sleep monitor, in patients with psychiatric disorders. One hundred and three patients undergoing polysomnography were enrolled in this study. Zmachine Insight Plus was performed simultaneously with polysomnography. Total sleep time, sleep efficiency, wake after sleep onset, rapid eye movement (REM) sleep, light sleep (stages N1 and N2) and deep sleep (stage N3) were assessed. Total sleep time, sleep efficiency, wake after sleep onset, REM sleep duration and non-REM sleep duration of Zmachine Insight Plus showed a significant correlation with those of polysomnography. Lower sleep efficiency and increased frequency of waking after sleep onset, the arousal index and the apnea–hypopnea index on polysomnography were significantly associated with the difference in sleep parameters between the two methods. Among patients with psychiatric disorders who are sensitive to environmental change, Zmachine Insight Plus would be a useful technique to objectively evaluate sleep quality.

DOI： 10.1111/jsr.13273

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Neuropsychopharmacology Reports  

Abnormal eye movements are often associated with psychiatric disorders. Eye movements are sensorimotor functions of the brain, and aging and sex would affect their characteristics. A precise understanding of normal eye movements is required to distinguish disease-related abnormalities from natural differences associated with aging or sex. To date, there is no multicohort study examining age-related dependency and sex effects of eye movements in healthy, normal individuals using large samples to ensure the robustness and reproducibility of the results. In this study, we aimed to provide findings showing the impact of age and sex on eye movement measures. The present study used eye movement measures of more than seven hundred healthy individuals from three large independent cohorts. We herein evaluated eye movement measures quantified by using a set of standard eye movement tests that have been utilized for the examination of patients with schizophrenia. We assessed the statistical significance of the effects of age and sex and its reproducibility across cohorts. We found that 4-18 out of 35 eye movement measures were significantly correlated with age, depending on the cohort, and that 10 of those, which are related to the fixation and motor control of smooth pursuit and saccades, showed high reproducibility. On the other hand, the effects of sex, if any, were less reproducible. The present results suggest that we should take age into account when we evaluate abnormalities in eye movements.

DOI： 10.1002/npr2.12163

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Scientific Reports  

Sleep disturbances and cognitive decline are common in older adults. We aimed to investigate the effects of the total sleep time (TST) and sleep–wake rhythm on executive function and working memory in older adults. In 63 older participants, we measured the TST, wake after sleep onset (WASO), and sleep timing (midpoint between bedtime and wake-up time) using actigraphy. Executive function was evaluated with the trail making test B (TMT-B) and Wisconsin card sorting test (WCST). The number of back task (N-back task) was used to measure working memory. Participants with a TST ≥ 8 h had a significantly lower percentage of correct answers (% correct) on the 1-back task than those with a TST < 8 h. The % correct on the 1-back task was significantly correlated with the TST, WASO, and sleep timing. Multiple regression analyses revealed that the TST and sleep timing were significant factors of the % correct on the 1-back task. The TMT-B score was significantly correlated with the sleep timing. Category achievement on the WCST was significantly correlated with the standard deviation of the sleep timing. Therefore, a long sleep time and an irregular sleep–wake rhythm could have adverse effects on executive function and working memory in older people.

DOI： 10.1038/s41598-021-85817-y

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Heating, Air-Conditioning and Sanitary Engineers of Japan, Chubu branch  

DOI： 10.18948/shasec.22.0_77

CiNii Research

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Sleep Science  

Introduction: Sleep is essential for performing cognitive function in humans. We have hypothesized that sleep fragmentation compared to sleep efficiency may have a negative impact on the working memory. Material and Methods: Twenty-eight healthy adults (18 males and 10 females; mean age 27.8±15.5 years) were enrolled in this study. We measured the total sleep time (TST), sleep efficiency, %stage wakefulness (W), %stage rapid eye movement (REM), %stage N1, %stage N2, %stage N3, wake after sleep onset (WASO), and arousal index using polysomnography. Working memory, executive function, and sustained attention of three domains of cognitive function were evaluated with the number of back task (N-back task), Wisconsin card sorting test (WCST), and continuous performance test-identical pairs (CPT-IP), respectively. Results: The percentage of correct answers on the 2-back task was significantly correlated with %stage REM, %stage N1, and %stage N2 (%stage REM: r=0.505, p=0.006; %stage N1: r=-0.637, p<0.001; %stage N2: r=0.670, p<0.001), and multiple regression analysis including the stepwise forward selection method revealed that %stage N2 was the most significant factor (%stage N2: β=0.670, p<0.001). The percentage of correct answers on the 2-back task was also significantly correlated with TST, sleep efficiency, WASO, and arousal index (TST: r=0.492, p=0.008; sleep efficiency: r=0.622, p<0.001; WASO: r=-0.721, p<0.001; arousal index: r=-0.656, p<0.001), and WASO was the significant factor (β=-2.086, p=0.007). The WCST category achievement and CPT-IP d-prime score were correlated with none of the sleep variables. Conclusion: Increased WASO and a decrease in %stage N2 were associated with worse working memory.

DOI： 10.5935/1984-0063.20200088

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DOI： 10.1007/s11325-019-01963-8

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DOI： 10.1080/10641963.2019.1632338

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CiNii Research

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DOI： 10.4103/jrms.JRMS_62_18

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DOI： 10.1007/s00702-019-02035-7

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Language：Japanese   Publishing type：Research paper (scientific journal)  

DOI： 10.1097/01.hjh.0000573244.64731.f2

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Clinical Physiology  

<p>Background: Valvular regurgitation, a degenerative condition, increases in prevalence with age. Its impact on left ventricular (LV) function in the elderly remains unclear, however.</p><p>Objective: The purpose of this study was to characterize the relationship between LV function and valvular regurgitation in middle-aged and elderly.</p><p>Methods: Echocardiography was performed to assess LV systolic and diastolic function in 98 community-dwelling middle-aged and older adults. Mitral regurgitation (MR) and aortic regurgitation (AR) were qualitatively graded from absent or trivial to severe.</p><p>Results: The LV ejection fraction was significantly higher and the deceleration time at the mitral level during rapid filling significantly longer in the MR group than in the non-MR group. The ratio of early diastolic wave peak velocity to mitral annular early diastolic peak velocity was significantly greater in the AR group than in the non-AR group.</p><p>Conclusions: Both MR and AR may play an important role in change in LV systolic and diastolic function, even in cases of mild regurgitation, in middle-aged and elderly.</p>

DOI： 10.34363/jocp.49.2_89

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DOI： 10.1080/09291016.2018.1433467

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DOI： 10.1002/npr2.12046

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：株式会社医学書院  

DOI： 10.11477/mf.1542201850

CiNii Research

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Oil Chemists' Society  

<p>Sleep plays an important role in metabolic regulation and insomnia disorder, short sleep and long sleep are also related with dyslipidemia. Among them especially, numerous evidence suggests that sleep disordered breathing is closely associated with dyslipidemia, hypertension and diabetes, and increases the risk of cardiovascular disease. In addition, in recent years, studies that elucidate the molecular mechanism of dyslipidemia due to sleep disorder by a mass spectrometer is increasing. The relationship between severity and lipid species profile in patients with obstructive sleep apnea has been reported, and the previous study revealed a significant overall shift in lipid metabolism, with higher levels of phospholipids under sleep-restricted conditions. Comprehensive analysis of lipid metabolites using a mass spectrometry further the understanding of sleep/wake regulation and the associated metabolic processes, and will be vital to identify robust biomarkers for disease states and drug efficacy. In this paper, we review epidemiological and mass spectrometric studies on the relationship between sleep and dyslipidemia.</p>

DOI： 10.5650/oleoscience.19.285

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DOI： 10.1002/hup.2678

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DOI： 10.1080/10641963.2018.1481419

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DOI： 10.1111/pcn.12651

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DOI： 10.1093/sleep/zsy061.560

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DOI： 10.1111/pcn.1246

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DOI： 10.1055/s-0043-110054

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DOI： 10.1002/gps.4477

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DOI： 10.1111/pcn.12464

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Association of Medical Technologists  

DOI： 10.14932/jamt.17j2-13

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DOI： 10.1002/jcu.22376

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DOI： 10.4172/2325-9639.1000168

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DOI： 10.1111/echo.12934

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DOI： doi: 10.1111/sbr.12130

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DOI： doi: 10.1111/echo.12934

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DOI： 10.2143/AC.70.3.3080632

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DOI： doi: 10.1155/2013/814169

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DOI： 10.1155/2013/814169

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DOI： 10.1016/j.diabres.2011.02.029

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DOI： 10.1038/ejhg.2010.201

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DOI： 10.1159/000321238

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Japan Society of Ultrasonics in Medicine  

<B>Purpose</B>: Three-dimensional (3D) echocardiography is useful for the accurate evaluation of left ventricular (LV) function, but its reliability during exercise remains unclear. We conducted an investigation to determine whether 3D echocardiography was practicable for evaluating LV function during exercise. <B>Subjects and Methods</B>: We studied 18 healthy subjects (12 males, 6 females: 22.7±1.8 years). All subjects underwent supine bicycle ergometer exercise tests. We compared stroke volume index (SVI, stroke volume / body surface area), cardiac index (CI, cardiac output / body surface area), and LV ejection fraction (LVEF) during exercise using pulsed wave Doppler (PWD) and two-dimensional (2D) and 3D echocardiography. The inter-observer and intra-observer variations were measured repeatedly during exercise. <B>Results</B>: The SVI and CI measured by 3D echocardiography continued to increase during exercise, and these were accompanied by heart rate elevation. The inter-observer and intra-observer variations in LV volume measured by 3D echocardiography were better than those for PWD and 2D echocardiography. We could evaluate the dyssynchrony at maximum exercise using 3D echocardiography. <B>Conclusion</B>: 3D echocardiography is a reproducible tool that could feasibly be used for the evaluation of LV function during exercise.

DOI： 10.3179/jjmu.35.409

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Circulation Society  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Circulation Society  

CiNii Research

Publishing type：Research paper (scientific journal)   Publisher：名古屋大学  

A home screening device, LT-200, can record data on both breathing conditions and body positions during sleep for up to 3 consecutive days in patients with obstructive sleep apnea (OSAS). We investigated the usefulness of the LT-200 device for follow-up of OSAS. Eighteen patients (age 51.0±10.8 years, mean±SD) were enrolled in this study. Standard polysomnography (PSG) was performed on all patients. The number of apnea/hypopnea episodes per hour (apnea/hypopnea index: AHI), the total time that nocturnal oxygen saturation was <90% (oxygen desaturation time: ODT), and the minimum oxygen saturation during sleep (lowest Spo_2) were calculated. We used the LT-200 and PSG to evaluate any improvement in the data obtained after auto-continuous positive airway pressure (auto-CPAP) therapy. AHI was also measured using the LT-200 in three sleep positions to evaluate the efficacy of the lateral position. AHI, ODT, and lowest Spo_2 values did not differ significantly between the PSG and LT-200 recordings on the control and therapy nights. The LT-200 recordings showed that AHI, ODT, and lowest Spo_2 tended to be better on the second night of auto-CPAP therapy than on the first. AHI was significantly lower in the right and left lateral sleep positions than that in the supine position. Our findings suggest that since the LT-200 device provides important information about the severity of OSAS, the efficacy of auto-CPAP therapy, and body position under unattended conditions in the home. It may prove to be a useful tool for following up patients.

DOI： 10.18999/nagjms.69.1-2.37

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：一般社団法人 日本超音波検査学会  

DOI： 10.11272/jssabst.32.0_214_2

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The electroencephalogram (EEG) during rapid eye movement (REM) sleep are characterized by fast rhythms and theta waves: mixed with distinctive saw-tooth waves, some hallmark of REM sleep is presence of rapid eye movements in all directions, the marked diminution or absence of muscle activities in the chin electromyography (EMG) and further reduction of responsiveness to stimulation. REM sleep is triggered by cholinoceptive and/or cholinergic "REM-on" cells, and terminated by aminergic (noradrenergic and serotonergic) inhibitory "REM-off" cells. Two processes participate in sleep regulation, namely, a homeostatic mechanism depending on sleep debt and the circadian system that regulates sleep induction and wakefulness. The firing rate of the suprachiasmatic nuclei (SCN) of the hypothalamus decreases in the transition from NREM to REM sleep, as shown by the simultaneous recording of EEG activity and SCN electrical activity. In healthy subjects, REM sleep decreased, slow wave sleep increased, sleep-onset latency decreased and late-night disturbance of sleep increased with increasing doses of alcohol. Sleep efficiency and total sleep time are generally higher in patients with behaviourally induced insufficient sleep syndrome (BIISS) than in patient with obstructive sleep apnea syndrome (OSAS) or narcolepsy. Compared to narcolepsy, patients with BISS tend to have less REM sleep, less stage 1 sleep, and more slow wave sleep on PSG. The multiple sleep latency test (MSLT) is essential in documenting pathological sleepiness and when diagnosing narcolepsy. The presence of two sleep onset REMs (SOREMPs) in four or five nap studies and sleep onset latency of less than 8 minutes strongly suggests a diagnosis of narcolepsy. One night of insufficient sleep involved in the changes of cortical oxygenation responses to brain activation as well as the deterioration of daytime cognitive function and driving performance. Sleep is a critical aspect of the pathophysiology and treatment of depression. Depression is characterized by a decrease of REM sleep latency and an increase of REM density. Given the relations between excessive daytime sleepiness/insomnia, traffic and industrial accident, life-threatening events, and cognitive and memory problems, an understanding of the sleep quality (REN/NREM) on psychiatric function is important for health practitioners. © 2012 by Nova Science Publishers, Inc. All rights reserved.

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CiNii Books

Event date： 2022.6

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Event date： 2019.7

Language：Japanese   Presentation type：Oral presentation (general)  

Event date： 2019.6

Language：Japanese   Presentation type：Poster presentation  

Event date： 2019.6

Language：Japanese   Presentation type：Poster presentation  

Event date： 2018.9

Language：English   Presentation type：Poster presentation  

Country：Switzerland  

Event date： 2018.9

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2018.7

Language：English   Presentation type：Poster presentation  

Country：Japan  

Event date： 2018.6

Language：English   Presentation type：Poster presentation  

Country：United States  

Event date： 2017.10

Language：English   Presentation type：Poster presentation  

Country：Czech Republic  

Event date： 2016.11

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2016.9

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2016.7

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2016.6 - 2019.6

Language：English   Presentation type：Poster presentation  

Event date： 2016.6

Language：English   Presentation type：Poster presentation  

Country：United States  

Event date： 2015.10

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2015.9

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2014.9

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2014.7

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2013.6

Language：Japanese   Presentation type：Poster presentation  

Venue：秋田   Country：Japan  

Event date： 2013.6

Language：English   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2013.6

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：秋田   Country：Japan  

Event date： 2013.6

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：秋田   Country：Japan  

Event date： 2013.4

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2013.3

Language：English   Presentation type：Poster presentation  

Country：Japan  

Event date： 2013.2

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2012.8

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2012.6

Language：English   Presentation type：Oral presentation (general)  

Country：United States  

Event date： 2012.6

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2012.3

Language：English   Presentation type：Oral presentation (general)  

Country：Czech Republic  

Event date： 2012.2

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2011.11

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2011.10

Language：English   Presentation type：Poster presentation  

Country：Japan  

Event date： 2011.10

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2011.4

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2011.3

Language：English   Presentation type：Poster presentation  

Country：Japan  

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)