Updated on 2021/05/15

写真a

 
WATANABE Seiji
 
Organization
Research Institute of Environmental Medicine Division of Stress Recognition and Response Assistant Professor
Graduate School of Medicine
Title
Assistant Professor
Contact information
メールアドレス
External link

Degree 1

  1. 博士(学術) ( 2012.3   東京大学 ) 

Research Interests 4

  1. Intracellular protein degradation

  2. Neuropathobiology

  3. Neurodegenarative diseases

  4. Amyotrophic Lateral Sclerosis (ALS)

Research History 4

  1. 名古屋大学 環境医学研究所 助教

    2014.4

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    Country:Japan

  2. Researcher, Department of Neuroscience and Pathobiology, Research Institute for Environmental Medicine, Nagoya university

    2013.11 - 2014.3

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    Country:Japan

  3. Researcher, Laboratory for Motor Neuron Disease, BSI, RIKEN

    2012.4 - 2013.10

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    Country:Japan

  4. JSPS Research Fellow

    2009.4 - 2012.3

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    Country:Japan

Education 2

  1. The University of Tokyo   Gradudate School of Arts and Sciences   Department of Life Sciences

    - 2012.3

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    Country: Japan

  2. The University of Tokyo   Faculty of Liberal Arts   Department of Life and Cognitive Sciences

    - 2007.3

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    Country: Japan

Professional Memberships 3

  1. The Japan Neuroscience Society

  2. The Japanese Biochemical Society

  3. The Japanese Society for Neurochemistry

 

Papers 30

  1. Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease Reviewed

    Sobue Akira, Komine Okiru, Hara Yuichiro, Endo Fumito, Mizoguchi Hiroyuki, Watanabe Seiji, Murayama Shigeo, Saito Takashi, Saido Takaomi C., Sahara Naruhiko, Higuchi Makoto, Ogi Tomoo, Yamanaka Koji

    ACTA NEUROPATHOLOGICA COMMUNICATIONS   Vol. 9 ( 1 ) page: 1   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40478-020-01099-x

    Web of Science

    PubMed

  2. Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43. Reviewed

    Watanabe S, Inami H, Oiwa K, Murata Y, Sakai S, Komine O, Sobue A, Iguchi Y, Katsuno M, Yamanaka K

    Cell death & disease   Vol. 11 ( 10 ) page: 909   2020.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41419-020-03116-2

    Web of Science

    PubMed

  3. Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis Reviewed International coauthorship

    Amporndanai Kangsa, Rogers Michael, Watanabe Seiji, Yamanaka Koji, O'Neill Paul M., Hasnain S. Samar

    EBIOMEDICINE   Vol. 59   page: 102980   2020.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ebiom.2020.102980

    Web of Science

    PubMed

  4. ALS-linked TDP-43<sup>M337V</sup> knock-in mice exhibit splicing deregulation without neurodegeneration. Reviewed

    Watanabe S, Oiwa K, Murata Y, Komine O, Sobue A, Endo F, Takahashi E, Yamanaka K

    Molecular brain   Vol. 13 ( 1 ) page: 8   2020.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13041-020-0550-4

    Web of Science

    PubMed

  5. Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway Reviewed

    Nishino Kohei, Watanabe Seiji, Shijie Jin, Murata Yuri, Oiwa Kotaro, Komine Okiru, Endo Fumito, Tsuiji Hitomi, Abe Manabu, Sakimura Kenji, Mishra Amit, Yamanaka Koji

    ACTA NEUROPATHOLOGICA COMMUNICATIONS   Vol. 7   2019.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40478-019-0776-5

    Web of Science

  6. Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes.

    Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K

    Cell death and differentiation   Vol. 25 ( 12 ) page: 2130 - 2146   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41418-018-0098-3

    Web of Science

    PubMed

  7. A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis.

    Tokuda E, Nomura T, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y

    Biochimica et biophysica acta   Vol. 1864 ( 6 ) page: 2119 - 2130   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbadis.2018.03.015

    Web of Science

    PubMed

  8. Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice. Reviewed

    Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K.

    Journal of Neurochemistry   Vol. 145 ( 1 ) page: 80 - 89   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jnc.14285

    Web of Science

    PubMed

  9. TDP-43 accelerates age-dependent degeneration of interneurons. Reviewed

    Tsuiji H, Inoue I, Takeuchi M, Furuya A, Yamakage Y, Watanabe S, Koike M, Hattori M, Yamanaka K.

    Scientific Reports   Vol. 7 ( 1 ) page: 14972   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-14966-w

    Web of Science

    PubMed

  10. Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth. Reviewed

    Takahashi N, Onozuka W, Watanabe S, Wakasugi K

    FEBS OPEN BIO   Vol. 7 ( 9 ) page: 1338-1349   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/2211-5463.12271

  11. Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis. Reviewed

    Tokuda E, Anzai I, Nomura T, Toichi K, Watanabe M, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y.

    Molecular Neurodegeneration   Vol. 12 ( 2 )   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13024-016-0145-9.

  12. Immunochemical characterization on pathological oligomers of mutant Cu/Znsuperoxide dismutase in amyotrophic lateral sclerosis

    Tokuda Eiichi, Anzai Itsuki, Nomura Takao, Toichi Keisuke, Watanabe Masahiko, Ohara Shinji, Watanabe Seiji, Yamanaka Koji, Morisaki Yuta, Misawa Hidemi, Furukawa Yoshiaki

    MOLECULAR NEURODEGENERATION   Vol. 12 ( 1 ) page: 2   2017.1

  13. Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS Reviewed

    Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, Yamanaka K

    EMBO Molecular Medicine     page: e201606403   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.15252/emmm.201606403

  14. Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons Reviewed

    Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, Yamanaka K

    Acta Neuropathologica Communications     page: 18;4:15.   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40478-016-0286-7

    PubMed

  15. Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model Reviewed

    Chhangani D, Endo F, Amanullah A, Upadhyay A, Watanabe S, Mishra R, Yamanaka K, Mishra A

    Neurobiology of Disease   Vol. 86   page: 16-28   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.nbd.2015.11.017

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  16. Astrocyte-Derived TGF-beta1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Reviewed

    Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K.

    Cell Reports   Vol. 11 ( 4 ) page: 592–604   2015.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: http://dx.doi.org/10.1016/j.celrep.2015.03.053

  17. Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity Reviewed

    Watanabe S, Hayakawa T, Wakasugi K, Yamanaka K

    Cell Death and Disease   Vol. 5   page: e1497   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  18. SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system Reviewed

    Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K

    Molecular Brain   Vol. 7 ( 62 ) page: 00   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  19. Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life

    Austin JA, Wright GS, Watanabe S, Grossmann JG, Antonyuk SV, Yamanaka K, Hasnain SS

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 111 ( 11 ) page: 4309–4314   2014.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  20. Crucial roles of glu60 in human neuroglobin as a Guanine nucleotide dissociation inhibitor and neuroprotective agent Reviewed

    Takahashi N, Watanabe S, Wakasugi K

    PLoS ONE   Vol. 8   page: e83698   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  21. Functional characterization of fish neuroglobin: Zebrafish neuroglobin is highly expressed in amacrine cells after optic nerve injury and can translocate into ZF4 cells Reviewed

    Kamioka Y, Fujikawa C, Ogai K, Sugitani K, Watanabe S, Kato S, Wakasugi K

    Biochim. Biophys. Acta   Vol. 1834 ( 9 ) page: 1779-­1788   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbapap.2013.02.021.

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  22. Human neuroglobin functions as an oxidative stress-­responsive sensor for neuroprotection Reviewed

    Watanabe S, Takahashi N, Uchida H, Wakasugi K

    J. Biol. Chem   Vol. 287 ( 36 ) page: 30128-­30138   2012.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M112.373381.

    PubMed

  23. Species-specific functional evolution of neuroglobin Reviewed

    Wakasugi K, Takahashi N, Uchida H, Watanabe S

    Mar. Genomics   Vol. 4 ( 3 ) page: 137-­142   2011.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.margen.2011.03.001.

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  24. Chimeric ZHHH neuroglobin is a novel cell-­membrane-­penetrating, neuroprotective agent Reviewed

    Wakasugi K, Takahashi N, Watanabe S

    Am. J. Neuroprotec. Neuroregen.   Vol. 3 ( 1 ) page: 42-47   2011.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1166/ajnn.2011.1025

  25. Module M1 of zebrafish neuroglobin acts as a structural and functional protein building block for a cell-­membrane-­penetrating activity Reviewed

    Watanabe S, Wakasugi K

    PLoS ONE   Vol. 6 ( 2 ) page: e16808   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0016808

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  26. Identification of residues critical for the cell-­membrane-­penetrating activity of zebrafish neuroglobin Reviewed

    Watanabe S, Wakasugi K

    FEBS Lett.   Vol. 584 ( 11 ) page: 2467-2472   2010.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.febslet.2010.04.054

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  27. Expression of neuroglobin in the zebrafish retina Reviewed

    Fujikawa C, Nagashima M, Mawatari K, Watanabe S, Wakasugi K, Kato S

    J. Physiol. Sci.   Vol. 60   page: S184   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

  28. Functional caharacterization of neuroglobin, a novel member of the vertebrate globin family Reviewed

    Watanabe S, Wakasugi K

    J. Biol. Inorg. Chem.   Vol. 14   page: S171   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

  29. Zebrafish neuroglobin is a cell-­membrane-­penetrating globin Reviewed

    Watanabe S, Wakasugi K

    Biochemistry   Vol. 47 ( 19 ) page: 5266-­5270   2008.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bi800286m

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  30. Neuroprotective activity of human neuroglobin is correlated with its guanine nucleotide dissociation inhibitor activity Reviewed

    Watanabe S, Wakasugi K

    Biochem. Biophys. Res. Commun.   Vol. 369 ( 2 ) page: 695-700   2008.5

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    Language:English   Publishing type:Research paper (scientific journal)  

▼display all

Books 2

  1. 筋萎縮性側索硬化症におけるMAMの破綻. 実験医学増刊 ミトコンドリアと疾患・老化

    渡邊征爾、山中宏二( Role: Joint author)

    羊土社  2019.7 

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    Language:Japanese

  2. BRAIN MEDICAL:特集 神経細胞変性のメカニズム:グリア細胞と神経変性

    渡邊征爾、山中宏二( Role: Joint author)

    メディカルレビュー社  2014.9 

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    Language:Japanese Book type:Scholarly book

Presentations 46

  1. 運動神経変性における小胞体・ミトコンドリア連関の破綻 Invited

    渡辺征爾、山中宏二

    第93回日本生化学会大会シンポジウム  2020.9 

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    Event date: 2020.9

    Presentation type:Oral presentation (invited, special)  

  2. Multimerization of TDP-43 plays a key role in determination of its subcellular localization

    2020.9 

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    Event date: 2020.9

    Presentation type:Poster presentation  

  3. ALS関連変異TDP-43M337Vノックインマウスは運動神経変性を伴わないスプライシング異常を生じる

    渡邊征爾、大岩康太郎、小峯 起、祖父江 顕、山中宏二

    第43回日本神経科学大会  2020.7 

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    Event date: 2020.7

    Presentation type:Oral presentation (general)  

  4. PEG修飾D-セリンデヒドラターゼの投与によるALSモデルマウスのD-セリン動態制御の試み

    廣瀬優太、北浦靖之、渡邊征爾、山中宏二、伊藤智和、邊見 久、吉村 徹

    日本ビタミン学会第72回大会  2020.6 

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    Event date: 2020.6

    Presentation type:Oral presentation (general)  

  5. TDP-43 mutant lacking its C-terminal domain induces age-dependent motor dysfunction in mice. International conference

    Watanabe S, Nishino K, Murata Y, Oiwa K, Yamanaka K.

    30th International Symposium on ALS/MND 

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    Event date: 2019.12

    Language:English   Presentation type:Poster presentation  

    Country:Australia  

  6. 家族性ALS/FTLD原因遺伝子によって引き起こされるTDP-43の凝集は2つの異なる経路によって生じる

    渡邊征爾、大岩康太郎、山中宏二

    第42回日本神経科学大会第62回日本神経化学会大会 

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    Event date: 2019.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:新潟市   Country:Japan  

  7. Intracerebroventricular administration of cystatin C extended the survival time of SOD1G93A mouse model International conference

    Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K

    29th International Symposium on ALS/MND 

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    Event date: 2018.12

    Language:English   Presentation type:Poster presentation  

    Venue:Glasgow   Country:United Kingdom  

  8. Mice deficient of C-terminal domain of TDP-43 develop age-dependent motor dysfunction via Notch1-Akt signaling pathway International conference

    Watanabe S, Nishino K, Matsuoka Y, Jin S, Komine O, Endo F,Tsuiji H, Sakimura K, Mishra A, Yamanaka K

    5th RNA metabolism in neurological desease conference, Satelite meeting of SFN 

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

    Venue:San Diego   Country:United States  

  9. Identification of MAM disruption as a general pathological mechanism in ALS.

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    Event date: 2018.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  10. TAR DNA binding protein-43 mutant lacking its C-terminal domain causes age-dependent motor dysfunction via Notch1-Akt signaling pathway.

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    Event date: 2018.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  11. Neuroprotective role of cystatin C in SOD1-linked amyotrophic lateral sclerosis

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    Event date: 2017.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  12. Mice Heterozygously lacking C-terminal domain of TDP-43 show age-dependent motor dysfunction International conference

    Nishino K, Watanabe S, Endo, F, Yamanaka K

    XXIII World Congress of Neurology 

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    Event date: 2017.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  13. Mitochondria-associated membrane is a novel therapeutic target for amyotrophic lateral sclerosis

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    Event date: 2017.7

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  14. オルガネラ連関の破綻からみた運動神経変性メカニズム.

    渡邊征爾

    第二回 医薬系3部局交流シンポジウム/環境医学研究所・群馬大学生体調節研究所合同シンポジウム 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋市   Country:Japan  

  15. Disruption of Mitochondria-associated membrance is a common pathomechanism both in SOD1-and SIGMAR1-linked ALS International conference

    Watanabe S, Yamanaka K

    The 27th International Symposium on ALS/MND 

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    Event date: 2016.12

    Language:English   Presentation type:Poster presentation  

    Venue:Dublin(Ireland)   Country:Ireland  

  16. In vivo and in vitro characterization of SOD1 in early stages of ALS as a precursor to insoluble aggregates. International conference

    Tokuda E, Anzai I, Nomura T, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y.

    The 27th International Symposium on ALS/MND 

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    Event date: 2016.12

    Language:English   Presentation type:Poster presentation  

    Venue:Dublin   Country:Ireland  

  17. Collapse of mitochondria-associated membrane in amyotrophic lateral sclerosis. Invited

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    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  18. Disruption of mitochondria-associated membranein amyotrophic lateral sclerosis

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    Event date: 2016.1

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  19. Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 and is defective in ALS mice International conference

    Chhangani D, Endo F, Amanullah A, Upadhyay A, Watanabe S, Mishra R, Mishra A, Yamanaka K

    26th International Symposium on ALS/MLD 

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    Event date: 2015.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  20. Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with neuroprotective functions of microglia and T cells. International conference

    Endo F, Komine O, Jin S, Watanabe S, Katsuno M, Sobue G, Wyss-Coray T, Yamanaka K

    26th International Symposium on ALS/MLD 

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    Event date: 2015.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  21. Calcium deregulation atmitochondria-associated membrane is important for motor neuronal degeneration in amyotrophic lateral sclerosis

    Watanabe S, Yamanaka K

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    Event date: 2015.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  22. アストロサイト由来TGF-β1はALSの疾患進行を規定する

    遠藤史人、小峯 起、金 世杰、渡邊征爾、山中宏二

    第27回日本神経免疫学会学術集会 

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    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:岐阜市   Country:Japan  

  23. Sigma 1 receptor deficiency is involved in motor neuronal degeneration through calcium deregulation at mitochondria-associated membrane

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  24. Coordinated activation of autophagy and cathepsin-mediated proteolysis inhibition is essential for neuroprotection by cystatin C against mutant SOD1-mediated toxicity International conference

    Watanabe S, Wakasugi K, Yamanaka K

    25th International Symposium on ALS/MND 

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    Event date: 2014.12

    Language:English   Presentation type:Poster presentation  

    Country:Belgium  

  25. The role of the infiltrating immune cells attracted by activated microglia in amyotrophic lateral sclerosis mice International conference

    Komine O, Yamashita H, Fujimori-Tonou N, Moriwaki Y, Endo F, Watanabe S, Misawa H, Yamanaka K

    Neuroscience 2014 Annual Meeting 

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    Event date: 2014.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  26. 変異SOD1由来の毒性に対するシスタチンCの神経細胞保護機構の解明

    渡邊征爾、若杉桂輔、山中宏二

    第37回日本神経科学大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  27. Cystatin C protected neuronal cells against mutant copper-­zinc superoxide dismutase (SOD1)-­mediated toxicity in vitro International conference

    Watanabe S, Wakasugi K, Yamanaka K

    24th International Symposium on ALS/MND 

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    Event date: 2013.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  28. ヒトのニューログロビンが持つ神経細胞保護メカニズムの解明

    高橋 望, 渡邊征爾, 若杉桂輔

    第86回日本生化学会大会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜市   Country:Japan  

  29. 変異スーパーオキシドジスムターゼ1(SOD1)はSOD1G93Aマウスにおい てミトコンドリア・小胞体膜間領域に蓄積する

    渡邊征爾, 山中宏二

    Neuro2013(第36回日本神経科学大会 第56回日本神経化学会大会 第23回日本神経回路学会大会 合同大会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都市   Country:Japan  

  30. ヒト・ニューログロビンが持つ神経細胞保護機能の作用機序の解明

    高橋 望, 渡邊征爾, 若杉桂輔

    第13回 東京大学生命科学シンポジウム 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京大学   Country:Japan  

  31. 魚類ニューログロビンが持つ細胞膜貫通特性の解明とその蛋白質工学的応用

    若杉桂輔、渡邊征爾

    第38回生体分子化学討論会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:茨城県つくば市   Country:Japan  

  32. 過剰発現系を用いたヒト・ニューログロビンの細胞死抑制機構の解明

    高橋 望, 渡邊征爾, 若杉桂輔

    第11回 東京大学生命科学シンポジウム 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京大学   Country:Japan  

  33. ゼブラフィッシュのニューログロビンが持つ細胞膜貫通特性に必須の残基の特定

    渡邊征爾, 若杉桂輔

    BMB2010(第83回日本生化学会大会 第33回日本分子生物学会年会 合同大会) 

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    Event date: 2010.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸   Country:Japan  

  34. 過剰発現系を用いたニューログロビンの細胞死抑制機構の解明

    高橋 望, 渡邊征爾, 若杉桂輔

    BMB2010(第83回日本生化学会 第33回日本分子生物学会 合同大会 

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    Event date: 2010.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸   Country:Japan  

  35. Chimeric ZHHH neuroglobin as a cell-­membrane-­penetrating neuroprotective globin International conference

    Watanabe S, Wakasugi K

    10th International Conference on Neuroprotective Agents 

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    Event date: 2010.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  36. Investigation of a neuroprotective mechanism of human neuroglobulin International conference

    Wakasugi K, Watanabe S

    10th International Conference on Neuroprotective Agents 

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    Event date: 2010.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  37. ゼブラフィッシュ網膜におけるニューログロビンの発現

    藤川千恵子, 永島幹子, 馬渡一浩, 渡邊征爾, 若杉桂輔, 加藤 聖

    第87回日本生理学会大会 

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    Event date: 2010.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:盛岡市   Country:Japan  

  38. 脳内グロビン蛋白質「ニューログロビン」の生理機能の解明

    渡邊征爾, 若杉桂輔

    第10回 東京大学生命科学シンポジウム 

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    Event date: 2010.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京大学   Country:Japan  

  39. 視神経損傷後のゼブラフィッ シュ網膜におけるニューログロビンの発現と局在

    藤川千恵子, 永島幹子, 馬渡一浩, 渡邊征爾, 若杉桂輔, 加藤 聖

    第56回中部日本生理学会大会 

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    Event date: 2009.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:石川県金沢市   Country:Japan  

  40. ヒトのニューログロビンによる神経細胞死の抑制には酸化ストレスに伴う構造変化が重要である

    渡邊征爾, 若杉桂輔

    第82回日本生化学会大会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸   Country:Japan  

  41. Functional characterization of neuroglobin, a novel member of the vertebrate globin family International conference

    Watanabe S, Wakasugi K

    14th International Conference on Biological Inorganic Chemistry 

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    Event date: 2009.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  42. ニューログロビンの新規機能の探索

    若杉桂輔、渡邊征爾

    第36回生体分子化学討論会 

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    Event date: 2009.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌市   Country:Japan  

  43. 脳内グロビン蛋白質「ニューログロビン」の新規機能の探索

    渡邊征爾, 若杉桂輔

    第9回日本蛋白質科学会年会 

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    Event date: 2009.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:熊本市   Country:Japan  

  44. ゼブラフィッシュのニューログロビンは細胞膜貫通特性をもつ

    渡邊征爾、若杉桂輔

    BMB2008(第81回日本生化学会大会 第31回日本分子生物学会年会 合同大会) 

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    Event date: 2008.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸市   Country:Japan  

  45. ニューログロビンの酸化ストレス下での神経細胞死抑制機構の解明

    渡邊征爾, 若杉桂輔

    BMB2007(第80回日本生化学会大会 第30回日本分子生物学会年会 合同大会) 

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    Event date: 2007.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜市   Country:Japan  

  46. 運動神経変性における小胞体・ミトコンドリア連関の破綻 Invited

    渡邊征爾、山中宏二

    第93回日本生化学会大会シンポジウム  2020.9 

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. タンパク質の構造生物学に基づいた筋萎縮性側索硬化症の分子病態解明と治療法開発

    Grant number:19KK0214  2019.4 - 2024.3

    日本学術振興会  科学研究費助成事業  国際共同研究加速基金(国際共同研究強化(B))

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  2. 小胞体・ミトコンドリア膜間領域の破綻に基づくALS病態の統合的理解

    Grant number:17H04986  2017.4 - 2022.3

    科学研究費補助金  若手研究(A)

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    Authorship:Principal investigator  Grant type:Competitive

  3. 神経変性疾患における小胞体・ミトコンドリア膜間領域の生理的意義の解明

    Grant number:25860252  2013.4 - 2017.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator  Grant type:Competitive