Implications of germline copy-number variations in psychiatric disorders: review of large-scale genetic studies 査読有り

Nakatochi Masahiro, Kushima Itaru, Ozaki Norio

JOURNAL OF HUMAN GENETICS   66 巻 ( 1 ) 頁： 25 - 37   2021年1月

ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk 査読有り

Sekiguchi Mariko, Sobue Akira, Kushima Itaru, Wang Chenyao, Arioka Yuko, Kato Hidekazu, Kodama Akiko, Kubo Hisako, Ito Norimichi, Sawahata Masahito, Hada Kazuhiro, Ikeda Ryosuke, Shinno Mio, Mizukoshi Chikara, Tsujimura Keita, Yoshimi Akira, Ishizuka Kanako, Takasaki Yuto, Kimura Hiroki, Xing Jingrui, Yu Yanjie, Yamamoto Maeri, Okada Takashi, Shishido Emiko, Inada Toshiya, Nakatochi Masahiro, Takano Tetsuya, Kuroda Keisuke, Amano Mutsuki, Aleksic Branko, Yamomoto Takashi, Sakuma Tetsushi, Aida Tomomi, Tanaka Kohichi, Hashimoto Ryota, Arai Makoto, Ikeda Masashi, Iwata Nakao, Shimamura Teppei, Nagai Taku, Nabeshima Toshitaka, Kaibuchi Kozo, Yamada Kiyofumi, Mori Daisuke, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   10 巻 ( 1 )   2020年7月

Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights 査読有り

Kushima Itaru, Aleksic Branko, Nakatochi Masahiro, Shimamura Teppei, Okada Takashi, Uno Yota, Morikawa Mako, Ishizuka Kanako, Shiino Tomoko, Kimura Hiroki, Arioka Yuko, Yoshimi Akira, Takasaki Yuto, Yu Yanjie, Nakamura Yukako, Yamamoto Maeri, Iidaka Tetsuya, Iritani Shuji, Inada Toshiya, Ogawa Nanayo, Shishido Emiko, Torii Youta, Kawano Naoko, Omura Yutaka, Yoshikawa Toru, Uchiyama Tokio, Yamamoto Toshimichi, Ikeda Masashi, Hashimoto Ryota, Yamamori Hidenaga, Yasuda Yuka, Someya Toshiyuki, Watanabe Yuichiro, Egawa Jun, Nunokawa Ayako, Itokawa Masanari, Arai Makoto, Miyashita Mitsuhiro, Kobori Akiko, Suzuki Michio, Takahashi Tsutomu, Usami Masahide, Kodaira Masaki, Watanabe Kyota, Sasaki Tsukasa, Kuwabara Hitoshi, Tochigi Mamoru, Nishimura Fumichika, Yamasue Hidenori, Eriguchi Yosuke, Benner Seico, Kojima Masaki, Yassin Walid, Munesue Toshio, Yokoyama Shigeru, Kimura Ryo, Funabiki Yasuko, Kosaka Hirotaka, Ishitobi Makoto, Ohmori Tetsuro, Numata Shusuke, Yoshikawa Takeo, Toyota Tomoko, Yamakawa Kazuhiro, Suzuki Toshimitsu, Inoue Yushi, Nakaoka Kentaro, Goto Yu-ichi, Inagaki Masumi, Hashimoto Naoki, Kusumi Ichiro, Son Shuraku, Murai Toshiya, Ikegame Tempei, Okada Naohiro, Kasai Kiyoto, Kunimoto Shohko, Mori Daisuke, Iwata Nakao, Ozaki Norio

CELL REPORTS   24 巻 ( 11 ) 頁： 2838-2856   2018年9月

High-resolution copy number variation analysis of schizophrenia in Japan 査読有り

Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T, Miyashita M, Kobori A, Arai M, Itokawa M, Cheng MC, Chuang YA, Chen CH, Suzuki M, Takahashi T, Hashimoto R, Yamamori H, Yasuda Y, Watanabe Y, Nunokawa A, Someya T, Ikeda M, Toyota T, Yoshikawa T, Numata S, Ohmori T, Kunimoto S, Mori D, Iwata N, Ozaki N.

Molecular Psychiatry   22 巻 ( 3 ) 頁： 430-440   2017年3月

Clinical manifestations of schizophrenia in four patients with variants in voltage-gated calcium channel-encoding genes: a case series 査読有り

Lo Tzuyao, Kushima Itaru, Aleksic Branko, Yoshimi Akira, Someya Toshiyuki, Watanabe Yuichiro, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES   77 巻 ( 1 ) 頁： 57 - 59   2023年1月

Turner syndrome presenting with idiopathic regression: A case report 査読有り

Mizobuchi Kosuke, Kushima Itaru, Kato Hidekazu, Miyajima Mari, Kimura Hiroyuki, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 12 ) 頁： 680 - 682   2022年12月

A case of bipolar disorder with AIF1 (coding gene of Iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells 査読有り

Ohgidani Masahiro, Kushima Itaru, Inamine Shogo, Kyuragi Sota, Sagata Noriaki, Nakao Tomohiro, Kanba Shigenobu, Ozaki Norio, Kato Takahiro A.

PSYCHIATRY AND CLINICAL NEUROSCIENCES     2022年11月

Establishment of induced pluripotent stem cells from a patient with 16p13.11 duplication and VPS13B deletion 査読有り

Okumura Hiroki, Arioka Yuko, Kushima Itaru, Mori Daisuke, Ozaki Norio

STEM CELL RESEARCH   64 巻   2022年10月

The genetic architecture of schizophrenia: review of large-scale genetic studies

Kato Hidekazu, Kimura Hiroki, Kushima Itaru, Takahashi Nagahide, Aleksic Branko, Ozaki Norio

JOURNAL OF HUMAN GENETICS     2022年7月

Psychiatric patients with a de novo 17q12 deletion: Two case reports 査読有り

Kushima Itaru, Uematsu Mariko, Ishizuka Kanako, Aleksic Branko, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 7 ) 頁： 345 - 347   2022年7月

Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients 査読有り

Nawa Yoshihiro, Kushima Itaru, Aleksic Branko, Yamamoto Maeri, Kimura Hiroyuki, Banno Masahiro, Hashimoto Ryota, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 7 ) 頁： 338 - 339   2022年7月

Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia

Chen Chia-Hsiang, Cheng Min-Chih, Hu Tsung-Ming, Ping Lieh-Yung, Kushima Itaru, Aleksic Branko

PSYCHIATRIC GENETICS   32 巻 ( 3 ) 頁： 125 - 130   2022年6月

Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder

Furuta Sho, Aleksic Branko, Nawa Yoshihiro, Kimura Hiroki, Kushima Itaru, Ishizuka Kanako, Kato Hidekazu, Toyama Miho, Arioka Yuko, Mori Daisuke, Morikawa Mako, Inada Toshiya, Ozaki Norio

NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 2 ) 頁： 260 - 268   2022年5月

Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial

Yamasue Hidenori, Kojima Masaki, Kuwabara Hitoshi, Kuroda Miho, Matsumoto Kaori, Kanai Chieko, Inada Naoko, Owada Keiho, Ochi Keiko, Ono Nobutaka, Benner Seico, Wakuda Tomoyasu, Kameno Yosuke, Inoue Jun, Harada Taeko, Tsuchiya Kenji, Umemura Kazuo, Yamauchi Aya, Ogawa Nanayo, Kushima Itaru, Ozaki Norio, Suyama Satoshi, Saito Takuya, Uemura Yukari, Hamada Junko, Kano Yukiko, Honda Nami, Kikuchi Saya, Seto Moe, Tomita Hiroaki, Miyoshi Noriko, Matsumoto Megumi, Kawaguchi Yuko, Kanai Koji, Ikeda Manabu, Nakamura Itta, Isomura Shuichi, Hirano Yoji, Onitsuka Toshiaki, Kosaka Hirotaka, Okada Takashi

BRAIN   145 巻 ( 2 ) 頁： 490 - 499   2022年4月

Variable psychiatric manifestations in patients with 16p11.2 duplication: a case series of 4 patients. 査読有り

Psychiatry Clin Neurosci.     2022年3月

Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population

Lo Tzuyao, Kushima Itaru, Aleksic Branko, Kato Hidekazu, Nawa Yoshihiro, Hayashi Yu, Otgonbayar Gantsooj, Kimura Hiroki, Arioka Yuko, Mori Daisuke, Ozaki Norio

INTERNATIONAL REVIEW OF PSYCHIATRY   34 巻 ( 2 ) 頁： 154 - 167   2022年2月

Trends in big data analyses by multicenter collaborative translational research in psychiatry. 招待有り 査読有り

Psychiatry Clin Neurosci.     2022年1月

Autism spectrum disorder comorbid with obsessive compulsive disorder and eating disorder in a woman with NBEA deletion. 査読有り

Psychiatry Clin Neurosci.     2022年1月

Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial. 査読有り

Brain     2022年

Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. 査読有り

Transl Psychiatry     2022年

Case report of a female with bipolar disorder and MBD5 deletion. 査読有り

Psychiatry Clin Neurosci.     2022年

Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia. 査読有り 国際共著

Psychiatr Genet.     2022年

Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients. 査読有り

Nawa Y, Kushima I, Aleksic B, Yamamoto M, Kimura H, Banno M, Hashimoto R, Ozaki N.

Psychiatry Clin Neurosci.     2022年

Psychiatric patients with a de novo 17q12 deletion: two case reports. 査読有り

Kushima I, Uematsu M, Ishizuka K, Aleksic B, Ozaki N.

Psychiatry Clin Neurosci.     2022年

Exome sequencing of Japanese schizophrenia multiplex families supports the involvement of calcium ion channels

Toyama Miho, Takasaki Yuto, Branko Aleksic, Kimura Hiroki, Kato Hidekazu, Nawa Yoshihiro, Kushima Itaru, Ishizuka Kanako, Shimamura Teppei, Ogi Tomoo, Ozaki Norio

PLOS ONE   17 巻 ( 5 )   2022年

AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity. 査読有り

Front Genet.     2021年12月

Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures. 査読有り

Sci Rep.     2021年6月

Dysregulation of post-transcriptional modification by copy number variable microRNAs in schizophrenia with enhanced glycation stress. 査読有り

Transl Psychiatry     2021年5月

Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders. 査読有り

Mol Brain.     2021年4月

Resequencing and association analysis of GAP43 with autism spectrum disorder and schizophrenia in a Japanese population 査読有り

Arta Reza K., Watanabe Yuichiro, Inoue Emiko, Nawa Yoshihiro, Morikawa Ryo, Egawa Jun, Kushima Itaru, Igeta Hirofumi, Hoya Satoshi, Sugimoto Atsunori, Tanra Andi J., Ozaki Norio, Someya Toshiyuki

  82 巻   2021年4月

Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons 査読有り

Hada Kazuhiro, Wulaer Bolati, Nagai Taku, Itoh Norimichi, Sawahata Masahito, Sobue Akira, Mizoguchi Hiroyuki, Mori Daisuke, Kushima Itaru, Nabeshima Toshitaka, Ozaki Norio, Yamada Kiyofumi

MOLECULAR BRAIN   14 巻 ( 1 )   2021年1月

Structural diverseness of neurons between brain areas and between cases 査読有り

Mizutani Ryuta, Saiga Rino, Yamamoto Yoshiro, Uesugi Masayuki, Takeuchi Akihisa, Uesugi Kentaro, Terada Yasuko, Suzuki Yoshio, De Andrade Vincent, De Carlo Francesco, Takekoshi Susumu, Inomoto Chie, Nakamura Naoya, Torii Youta, Kushima Itaru, Iritani Shuji, Ozaki Norio, Oshima Kenichi, Itokawa Masanari, Arai Makoto

  11 巻 ( 1 )   2021年1月

Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons 査読有り

  63 巻   2021年1月

Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder 査読有り

Kato Hidekazu, Kushima Itaru, Mori Daisuke, Yoshimi Akira, Aleksic Branko, Nawa Yoshihiro, Toyama Miho, Furuta Sho, Yu Yanjie, Ishizuka Kanako, Kimura Hiroki, Arioka Yuko, Tsujimura Keita, Morikawa Mako, Okada Takashi, Inada Toshiya, Nakatochi Masahiro, Shinjo Keiko, Kondo Yutaka, Kaibuchi Kozo, Funabiki Yasuko, Kimura Ryo, Suzuki Toshimitsu, Yamakawa Kazuhiro, Ikeda Masashi, Iwata Nakao, Takahashi Tsutomu, Suzuki Michio, Okahisa Yuko, Takaki Manabu, Egawa Jun, Someya Toshiyuki, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   10 巻 ( 1 )   2020年12月

Involvement of nicotinic acetylcholine receptors in behavioral abnormalities and psychological dependence in schizophrenia-like model mice 査読有り

Noda Yukihiro, Uchida Mizuki, Mouri Akihiro, Yamada Shokuro, Goto Sakika, Kitagaki Shinji, Mamiya Takayoshi, Kushima Itaru, Arioka Yuko, Ozaki Norio, Yoshimi Akira

  41 巻   頁： 92 - 105   2020年12月

Support vector machine-based classification of schizophrenia patients and healthy controls using structural magnetic resonance imaging from two independent sites 査読有り

Yamamoto Maeri, Bagarinao Epifanio, Kushima Itaru, Takahashi Tsutomu, Sasabayashi Daiki, Inada Toshiya, Suzuki Michio, Iidaka Tetsuya, Ozaki Norio

  15 巻 ( 11 )   2020年11月

Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility 査読有り

Nawa Yoshihiro, Kimura Hiroki, Mori Daisuke, Kato Hidekazu, Toyama Miho, Furuta Sho, Yu Yanjie, Ishizuka Kanako, Kushima Itaru, Aleksic Branko, Arioka Yuko, Morikawa Mako, Okada Takashi, Inada Toshiya, Kaibuchi Kozo, Ikeda Masashi, Iwata Nakao, Suzuki Michio, Okahisa Yuko, Egawa Jun, Someya Toshiyuki, Nishimura Fumichika, Sasaki Tsukasa, Ozaki Norio

HUMAN GENOME VARIATION   7 巻 ( 1 )   2020年11月

Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia 査読有り

Ishizuka Kanako, Yoshida Tomoyuki, Kawabata Takeshi, Imai Ayako, Mori Hisashi, Kimura Hiroki, Inada Toshiya, Okahisa Yuko, Egawa Jun, Usami Masahide, Kushima Itaru, Morikawa Mako, Okada Takashi, Ikeda Masashi, Branko Aleksic, Mori Daisuke, Someya Toshiyuki, Iwata Nakao, Ozaki Norio

  12 巻 ( 1 )   2020年9月

The accumulation of advanced glycation end-products in a schizophrenic patient with a glyoxalase 1 frameshift mutation: An autopsy study 査読有り

Torii Youta, Iritani Shuji, Sekiguchi Hirotaka, Habuchi Chikako, Fujishiro Hiroshige, Kushima Itaru, Kawakami Ito, Itokawa Masanari, Arai Makoto, Hayashida Shotaro, Masaki Katsuhisa, Kira Jun-ichi, Kawashima Kunihiro, Ozaki Norio

  223 巻   頁： 356 - 358   2020年9月

Morphological alteration of myelin-oligodendrocytes in a schizophrenic patient with 22q11.2 deletion syndrome: An autopsy study

Torii Youta, Iritani Shuji, Marui Tomoyasu, Sekiguchi Hirotaka, Habuchi Chikako, Fujishiro Hiroshige, Kushima Itaru, Oshima Kenichi, Niizato Kazuhiro, Hayashida Shotaro, Masaki Katsuhisa, Kira Jun-ichi, Yoshida Mari, Ozaki Norio

SCHIZOPHRENIA RESEARCH   223 巻   頁： 353 - 355   2020年9月

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial 査読有り

Yamasue Hidenori, Okada Takashi, Munesue Toshio, Kuroda Miho, Fujioka Toru, Uno Yota, Matsumoto Kaori, Kuwabara Hitoshi, Mori Daisuke, Okamoto Yuko, Yoshimura Yuko, Kawakubo Yuki, Arioka Yuko, Kojima Masaki, Yuhi Teruko, Owada Keiho, Yassin Walid, Kushima Itaru, Benner Seico, Ogawa Nanayo, Eriguchi Yosuke, Kawano Naoko, Uemura Yukari, Yamamoto Maeri, Kano Yukiko, Kasai Kiyoto, Higashida Haruhiro, Ozaki Norio, Kosaka Hirotaka

MOLECULAR PSYCHIATRY   25 巻 ( 8 ) 頁： 1849 - 1858   2020年8月

A recurrentPJA1variant in trigonocephaly and neurodevelopmental disorders 査読有り

Suzuki Toshimitsu, Suzuki Toshifumi, Raveau Matthieu, Miyake Noriko, Sudo Genki, Tsurusaki Yoshinori, Watanabe Takaki, Sugaya Yuki, Tatsukawa Tetsuya, Mazaki Emi, Shimohata Atsushi, Kushima Itaru, Aleksic Branko, Shiino Tomoko, Toyota Tomoko, Iwayama Yoshimi, Nakaoka Kentaro, Ohmori Iori, Sasaki Aya, Watanabe Ken, Hirose Shinichi, Kaneko Sunao, Inoue Yushi, Yoshikawa Takeo, Ozaki Norio, Kano Masanobu, Shimoji Takeyoshi, Matsumoto Naomichi, Yamakawa Kazuhiro

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY   7 巻 ( 7 ) 頁： 1117 - 1131   2020年7月

Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia 査読有り

Sawahata Masahito, Mori Daisuke, Arioka Yuko, Kubo Hisako, Kushima Itaru, Kitagawa Kanako, Sobue Akira, Shishido Emiko, Sekiguchi Mariko, Kodama Akiko, Ikeda Ryosuke, Aleksic Branko, Kimura Hiroki, Ishizuka Kanako, Nagai Taku, Kaibuchi Kozo, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES   74 巻 ( 5 ) 頁： 318 - 327   2020年5月

Cell body shape and directional movement stability in human-induced pluripotent stem cell-derived dopaminergic neurons 査読有り

Arioka Yuko, Shishido Emiko, Kushima Itaru, Mori Daisuke, Ozaki Norio

SCIENTIFIC REPORTS   10 巻 ( 1 )   2020年4月

Cutting-edge morphological studies of post-mortem brains of patients with schizophrenia and potential applications of X-ray nanotomography (nano-CT)

Itokawa Masanari, Oshima Kenichi, Arai Makoto, Torii Yota, Kushima Itaru, Iritani Shuji, Ozaki Norio, Saiga Rino, Mizutani Ryuta

PSYCHIATRY AND CLINICAL NEUROSCIENCES   74 巻 ( 3 ) 頁： 176 - 182   2020年3月

Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus

Saito Ryo, Koebis Michinori, Nagai Taku, Shimizu Kimiko, Liao Jingzhu, Wulaer Bolati, Sugaya Yuki, Nagahama Kenichiro, Uesaka Naofumi, Kushima Itaru, Mori Daisuke, Maruyama Kazuaki, Nakao Kazuki, Kurihara Hiroki, Yamada Kiyofumi, Kano Masanobu, Fukada Yoshitaka, Ozaki Norio, Aiba Atsu

TRANSLATIONAL PSYCHIATRY   10 巻 ( 1 )   2020年2月

Characterization of a schizophrenia patient with a rare RELN deletion by combining genomic and patient-derived cell analyses

Arioka Yuko, Hirata Akihiro, Kushima Itaru, Aleksic Branko, Mori Daisuke, Ozaki Norio

SCHIZOPHRENIA RESEARCH   216 巻   頁： 511 - 515   2020年2月

Polygenic risk scores in schizophrenia with clinically significant copy number variants

Taniguchi Satoru, Ninomiya Kohei, Kushima Itaru, Saito Takeo, Shimasaki Ayu, Sakusabe Takaya, Momozawa Yukihide, Kubo Michiaki, Kamatani Yoichiro, Ozaki Norio, Ikeda Masashi, Iwata Nakao

PSYCHIATRY AND CLINICAL NEUROSCIENCES   74 巻 ( 1 ) 頁： 35 - 39   2020年1月

A network of networks approach for modeling interconnected brain tissue-specific networks

Kawakubo Hideko, Matsui Yusuke, Kushima Itaru, Ozaki Norio, Shimamura Teppei

BIOINFORMATICS   35 巻 ( 17 ) 頁： 3092 - 3101   2019年9月

Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect

Ikeda Masashi, Takahashi Atsushi, Kamatanim Yoichiro, Momozawa Yukihide, Saito Takeo, Kondo Kenji, Shimasaki Ayu, Kawase Kohei, Sakusabe Takaya, Iwayama Yoshimi, Toyota Tomoko, Wakudas Tomoyasu, Kikuchi Mitsuru, Kanahara Nobuhisa, Yamamori Hidenaga, Yasuda Yuka, Watanabe Yuichiro, Hoya Satoshi, Aleksic Branko, Kushima Itaru, Arai Heii, Takaki Manabu, Hattori Kotaro, Kurrugi Hiroshi, Okahisa Yuko, Ohnuma Tohru, Ozaki Norio, Someya Toshiyuki, Hashimotovs Ryota, Yoshikawa Takeo, Kubo Michiaki, Iwata Nakao

SCHIZOPHRENIA BULLETIN   45 巻 ( 4 ) 頁： 824 - 834   2019年7月

Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism

Owada Keiho, Okada Takashi, Munesue Toshio, Kuroda Miho, Fujioka Toru, Uno Yota, Matsumoto Kaori, Kuwabara Hitoshi, Mori Daisuke, Okamoto Yuko, Yoshimura Yuko, Kawakubo Yuki, Arioka Yuko, Kojima Masaki, Yuhi Teruko, Yassin Walid, Kushima Itaru, Benner Seico, Ogawa Nanayo, Kawano Naoko, Eriguchi Yosuke, Uemura Yukari, Yamamoto Maeri, Kano Yukiko, Kasai Kiyoto, Higashida Haruhiro, Ozaki Norio, Kosaka Hirotaka, Yamasue Hidenori

BRAIN   142 巻   頁： 2127 - 2136   2019年7月

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients

Yoshimi Akira, Yamada Shinnosuke, Kunimoto Shohko, Aleksic Branko, Hirakawa Akihiro, Ohashi Mitsuki, Matsumoto Yurie, Hada Kazuhiro, Itoh Norimichi, Arioka Yuko, Kimura Hiroki, Kushima Itaru, Nakamura Yukako, Shiino Tomoko, Mori Daisuke, Tanaka Satoshi, Hamada Shuko, Noda Yukihiro, Nagai Taku, Yamada Kiyofumi, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   9 巻   2019年4月

Three-dimensional alteration of neurites in schizophrenia

Mizutani Ryuta, Saiga Rino, Takeuchi Akihisa, Uesugi Kentaro, Terada Yasuko, Suzuki Yoshio, De Andrade Vincent, De Carlo Francesco, Takekoshi Susumu, Inomoto Chie, Nakamura Naoya, Kushima Itaru, Iritani Shuji, Ozaki Norio, Ide Soichiro, Ikeda Kazutaka, Oshima Kenichi, Itokawa Masanari, Arai Makoto

TRANSLATIONAL PSYCHIATRY   9 巻   2019年2月

A NOVEL RARE VARIANT R292H IN RTN4R AFFECTS GROWTH CONE FORMATION AND POSSIBLY CONTRIBUTES TO SCHIZOPHRENIA SUSCEPTIBILITY

Kimura Hiroki, Ishizuka Kanako, Wang Chenyao, Kushima Itaru, Morikawa Mako, Uno Yota, Okada Takashi, Inanda Toshiya, Aleksic Branko, Mori Daisuke, Ozaki Norio

EUROPEAN NEUROPSYCHOPHARMACOLOGY   29 巻   頁： S1014 - S1014   2019年

In Vitro Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of PCDH15 and RELN

Ishii Takaya, Ishikawa Mitsuru, Fujimori Koki, Maeda Takuji, Kushima Itaru, Arioka Yuko, Mori Daisuke, Nakatake Yuhki, Yamagata Bun, Nio Shintaro, Kato Takahiro A., Yang Nan, Wernig Marius, Kanba Shigenobu, Mimura Masaru, Ozaki Norio, Okano Hideyuki

ENEURO   6 巻 ( 5 )   2019年

Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability

Kunisawa Kazuo, Shimizu Takeshi, Kushima Itaru, Aleksic Branko, Mori Daisuke, Osanai Yasuyuki, Kobayashi Kenta, Taylor Anna M., Bhat Manzoor A., Hayashi Akiko, Baba Hiroko, Ozaki Norio, Ikenaka Kazuhiro

JOURNAL OF NEUROCHEMISTRY   147 巻 ( 3 ) 頁： 395-408   2018年11月

Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia

Ishizuka Kanako, Kimura Hiroki, Kushima Itaru, Inada Toshiya, Okahisa Yuko, Ikeda Masashi, Iwata Nakao, Mori Daisuke, Aleksic Branko, Ozaki Norio

PSYCHIATRIC GENETICS   28 巻 ( 5 ) 頁： 90-93   2018年10月

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia

Sobue Akira, Kushima Itaru, Nagai Taku, Shan Wei, Kohno Takao, Aleksic Branko, Aoyama Yuki, Mori Daisuke, Arioka Yuko, Kawano Naoko, Yamamoto Maeri, Hattori Mitsuharu, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio

SCIENTIFIC REPORTS   8 巻   2018年8月

Three lines of induced pluripotent stem cells derived from a 15q11.2-q13.1 duplication syndrome patient

Arioka Yuko, Kushima Itaru, Mori Daisuke, Ozaki Norio

STEM CELL RESEARCH   31 巻   頁： 240-243   2018年8月

Single-cell trajectory analysis of human homogenous neurons carrying a rare RELN variant

Arioka Yuko, Shishido Emiko, Kubo Hisako, Kushima Itaru, Yoshimi Akira, Kimura Hiroki, Ishizuka Kanako, Aleksic Branko, Maeda Takuji, Ishikawa Mitsuru, Kuzumaki Naoko, Okano Hideyuki, Mori Daisuke, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   8 巻   2018年7月

Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion

Arioka Yuko, Kushima Itaru, Kubo Hisako, Mori Daisuke, Ozaki Norio

STEM CELL RESEARCH   30 巻   頁： 81-84   2018年7月

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial. 査読有り

Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H.

Mol Psychiatry.     2018年6月

Aberrant functional connectivity between the thalamus and visual cortex is related to attentional impairment in schizophrenia. 査読有り

Yamamoto M, Kushima I, Suzuki R, Branko A, Kawano N, Inada T, Iidaka T, Ozaki N.

Psychiatry Res Neuroimaging.     2018年6月

Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion. 査読有り

Arioka Y, Kushima I, Kubo H, Mori D, Ozaki N.

Stem Cell Res.     2018年5月

Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder

Takata Atsushi, Miyake Noriko, Tsurusaki Yoshinori, Fukai Ryoko, Miyatake Satoko, Koshimizu Eriko, Kushima Itaru, Okada Takashi, Morikawa Mako, Uno Yota, Ishizuka Kanako, Nakamura Kazuhiko, Tsujii Masatsugu, Yoshikawa Takeo, Toyota Tomoko, Okamoto Nobuhiko, Hiraki Yoko, Hashimoto Ryota, Yasuda Yuka, Saitoh Shinji, Ohashi Kei, Sakai Yasunari, Ohga Shouichi, Hara Toshiro, Kato Mitsuhiro, Nakamura Kazuyuki, Ito Aiko, Seiwa Chizuru, Shirahata Emi, Osaka Hitoshi, Matsumoto Ayumi, Takeshita Saoko, Tohyama Jun, Saikusa Tomoko, Matsuishi Toyojiro, Nakamura Takumi, Tsuboi Takashi, Kato Tadafumi, Suzuki Toshifumi, Saitsu Hirotomo, Nakashima Mitsuko, Mizuguchi Takeshi, Tanaka Fumiaki, Mori Norio, Ozaki Norio, Matsumoto Naomichi

CELL REPORTS   22 巻 ( 3 ) 頁： 734-747   2018年1月

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility

Yu Yanjie, Lin Yingni, Takasaki Yuto, Wang Chenyao, Kimura Hiroki, Xing Jingrui, Ishizuka Kanako, Toyama Miho, Kushima Itaru, Mori Daisuke, Arioka Yuko, Uno Yota, Shiino Tomoko, Nakamura Yukako, Okada Takashi, Morikawa Mako, Ikeda Masashi, Iwata Nakao, Okahisa Yuko, Takaki Manabu, Sakamoto Shinji, Someya Toshiyuki, Egawa Jun, Usami Masahide, Kodaira Masaki, Yoshimi Akira, Oya-Ito Tomoko, Aleksic Branko, Ohno Kinji, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   8 巻   2018年1月

IDENTIFICATION OF RARE DISRUPTIVE VARIANTS IN VOLTAGE-GATED CHANNEL GENES (CACNA1C, CACNA1D, CACNA1S, CACNA1I) IN JAPANESE SAMPLES OF SCHIZOPHRENIA AND AUTISM SPECTRUM DISORDER USING ION TORRENT PGM PLATFORM

Wang Chenyao, Kimura Hiroki, Xing Jingrui, Ishizuka Kanoko, Kushima Itaru, Arioka Yuko, Yoshimi Akira, Nakamura Yukako, Shiino Yomoko, Oya Yuko, Takasaki Yuto, Aleksic Branko, Mori Daisuke, Ozaki Norio

EUROPEAN NEUROPSYCHOPHARMACOLOGY   27 巻   頁： S341-S342   2017年10月

MUTATION SCREENING OF THE PCDH15 GENE IN PATIENTS SUFFERING FROM AUTISM SPECTRUM DISORDERS AND SCHIZOPHRENIA

Ishizuka Kanako, Wang Chenyao, Kimura Hiroki, Xing Jingrui, Kushima Itaru, Arioka Yuko, Yoshimi Akira, Nakamura Yukako, Oya-Ito Tomoko, Takasaki Yuto, Uno Yota, Okada Takashi, Mori Daisuke, Aleksic Branko, Ozaki Norio

EUROPEAN NEUROPSYCHOPHARMACOLOGY   27 巻   頁： S162-S163   2017年10月

Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder

Lim Elaine T., Uddin Mohammed, De Rubeis Silvia, Chan Yingleong, Kamumbu Anne S., Zhang Xiaochang, D'Gama Alissa M., Kim Sonia N., Hill Robert Sean, Goldberg Arthur P., Poultney Christopher, Minshew Nancy J., Kushima Itaru, Aleksic Branko, Ozaki Norio, Parellada Mara, Arango Celso, Penzol Maria J., Carracedo Angel, Kolevzon Alexander, Hultman Christina M., Weiss Lauren A., Fromer Menachem, Chiocchetti Andreas G., Freitag Christine M., Church George M., Scherer Stephen W., Buxbaum Joseph D., Walsh Christopher A.

NATURE NEUROSCIENCE   20 巻 ( 9 ) 頁： 1217-+   2017年9月

A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility

Kimura H., Fujita Y., Kawabata T., Ishizuka K., Wang C., Iwayama Y., Okahisa Y., Kushima I., Morikawa M., Uno Y., Okada T., Ikeda M., Inada T., Branko A., Mori D., Yoshikawa T., Iwata N., Nakamura H., Yamashita T., Ozaki N.

TRANSLATIONAL PSYCHIATRY   7 巻   2017年8月

Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders

Ishizuka K., Fujita Y., Kawabata T., Kimura H., Iwayama Y., Inada T., Okahisa Y., Egawa J., Usami M., Kushima I., Uno Y., Okada T., Ikeda M., Aleksic B., Mori D., Someya To, Yoshikawa T., Iwata N., Nakamura H., Yamashita T., Ozaki N.

TRANSLATIONAL PSYCHIATRY   7 巻   2017年8月

Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility. 査読有り

Kimura H, Kushima I, Yohimi A, Aleksic B, Ozaki N.

Int J Neuropsychopharmacol.     2017年

Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders. 査読有り

Ishizuka K, Tabata H, Ito H, Kushima I, Noda M, Yoshimi A, Usami M, Watanabe K, Morikawa M, Uno Y, Okada T, Mori D, Aleksic B, Ozaki N, Nagata KI.

J Neurosci Res.     2017年

Single-neuron and genetic correlates of autistic behavior in macaque. 査読有り

Yoshida K, Go Y, Kushima I, Toyoda A, Fujiyama A, Imai H, Saito N, Iriki A, Ozaki N, Isoda M.

Sci Adv.   2 巻 ( 9 ) 頁： e1600558   2016年9月

Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders. 査読有り

Isles AR, Ingason A, Lowther C, Walters J, Gawlick M, Stöber G, Rees E, Martin J, Little RB, Potter H, Georgieva L, Pizzo L, Ozaki N, Aleksic B, Kushima I, Ikeda M, Iwata N, Levinson DF, Gejman PV, Shi J, Sanders AR, Duan J, Willis J, Sisodiya S, Costain G, Werge TM, Degenhardt F, Giegling I, Rujescu D, Hreidarsson SJ, Saemundsen E, Ahn JW, Ogilvie C, Girirajan SD, Stefansson H, Stefansson K, O'Donovan MC, Owen MJ, Bassett A, Kirov G.

PLoS Genet.   12 巻 ( 5 ) 頁： e1005993   2016年5月

自閉スペクトラム症の発症に関わる ゲノムバリアント

（ 担当： 共著）

CLINICAL NEUROSCIENCE  2022年 

精神科臨床 Legato ARHGAP10遺伝子変異と統合失調症発症の関連

（ 担当： 共著）

メディカルレビュー社  2021年3月 

統合失調症の発症と自閉スペクトラム症とのオーバーラップ

久島周（ 担当： 共著）

先端医学社  2021年3月 

「精神医学における科学的基盤」　ゲノムと精神医学―精神疾患のゲノム基盤と遺伝環境相互作用解明はどのようにして精神医学にイノベーションをもたらすか

学樹書院  2020年1月 

細胞　稀なバリアントに着目した精神疾患のゲノム研究

ニューサイエンス社  2019年12月 

分子精神医学　ヒトゲノムコピー数変異（CNV）

岩田仲生他（ 担当： 共著）

先端医学社  2015年4月 

図説　分子病態学　第5版　精神疾患：統合失調症と双極性障害

一瀬白帝他（ 担当： 共著）

中外医学社  2014年1月 

ファインケミカル　精神障害のゲノム研究

糸川昌成他（ 担当： 共著）

シーエムシー出版  2012年7月 

BRAIN and NERVE　発達期精神障害─発達障害を中心に

笠井清登他（ 担当： 共著）

医学書院  2012年 

精神医学キーワード辞典　うつ病の遺伝子・環境相関仮説

松下正明他（ 担当： 共著）

中山書店  2011年7月 

精神医学領域の論文を読みこなすキーワード100　ゲノムコピー数変異

新興医学出版社 

統合失調症のゲノムコピー数変異（CNV）解析

久島周他

第３回霊長類認知ゲノミクスワークショップ 

臨床と遺伝子像　自閉スペクトラム症（ASD）の遺伝子解析から　最近わかってきたこと

久島周他

第4回日本情動学会　シンポジウム