Inconsistent embryo selection across polygenic score methods 査読有り

Namba, S; Akiyama, M; Hamanoue, H; Kato, K; Kawashima, M; Kushima, I; Matsuda, K; Nakatochi, M; Ogishima, S; Sonehara, K; Suzuki, K; Takata, A; Tamiya, G; Tanikawa, C; Yamamoto, K; Yamamoto, N; BioBank Japan Project; Ozaki, N; Okada, Y

NATURE HUMAN BEHAVIOUR   8 巻 ( 12 ) 頁： 2264 - 2267   2024年12月

Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice 査読有り

Mori, D; Ikeda, R; Sawahata, M; Yamaguchi, S; Kodama, A; Hirao, T; Arioka, Y; Okumura, H; Inami, C; Suzuki, T; Hayashi, Y; Kato, H; Nawa, Y; Miyata, S; Kimura, H; Kushima, I; Aleksic, B; Mizoguchi, H; Nagai, T; Nakazawa, T; Hashimoto, R; Kaibuchi, K; Kume, K; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY   14 巻 ( 1 )   2024年3月

Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction 査読有り

Ishikawa, M; Yamamoto, Y; Wulaer, B; Kunisawa, K; Fujigaki, H; Ando, T; Kimura, H; Kushima, I; Arioka, Y; Torii, Y; Mouri, A; Ozaki, N; Nabeshima, T; Saito, K

FEBS JOURNAL   291 巻 ( 5 ) 頁： 945 - 964   2024年3月

Association between copy number variations in parkin (<i>PRKN</i>) and schizophrenia and autism spectrum disorder: A case-control study 査読有り

Lo, TY; Kushima, I; Kimura, H; Aleksic, B; Okada, T; Kato, H; Inada, T; Nawa, Y; Torii, Y; Yamamoto, M; Kimura, R; Funabiki, Y; Kosaka, H; Numata, S; Kasai, K; Sasaki, T; Yokoyama, S; Munesue, T; Hashimoto, R; Yasuda, Y; Fujimoto, M; Usami, M; Itokawa, M; Arai, M; Ohi, K; Someya, T; Watanabe, Y; Egawa, J; Takahashi, T; Suzuki, M; Yamasue, H; Iwata, N; Ikeda, M; Ozaki, N

Neuropsychopharmacology Reports   44 巻 ( 1 ) 頁： 42 - 50   2024年3月

Mesenchymal stem/stromal cells generated from induced pluripotent stem cells are highly resistant to senescence 査読有り

Aoi, T; Tanaka, A; Furuhashi, K; Ikeya, M; Shimizu, A; Arioka, Y; Kushima, I; Ozaki, N; Maruyama, S

NAGOYA JOURNAL OF MEDICAL SCIENCE   85 巻 ( 4 ) 頁： 682 - 690   2023年11月

Case reports of two siblings with autism spectrum disorder and 15q13.3 deletions 査読有り

Furukawa, S; Kushima, I; Aleksic, B; Ozaki, N

NEUROPSYCHOPHARMACOLOGY REPORTS   43 巻 ( 3 ) 頁： 462 - 466   2023年9月

De novo<i> MCM6</i> variants in neurodevelopmental disorders: a recognizable phenotype related to zinc binding residues 査読有り

Smits, DJ; Schot, R; Popescu, CA; Dias, KR; Ades, L; Briere, LC; Sweetser, DA; Kushima, I; Aleksic, B; Khan, S; Karageorgou, V; Ordonez, N; Sleutels, FJGT; van der Kaay, DCM; Van Mol, C; Van Esch, H; Bertoli-Avella, AM; Roscioli, T; Mancini, GMS

HUMAN GENETICS   142 巻 ( 7 ) 頁： 949 - 964   2023年7月

Structural aging of human neurons is opposite of the changes in schizophrenia 査読有り

Mizutani, R; Saiga, R; Yamamoto, Y; Uesugi, M; Takeuchi, A; Uesugi, K; Terada, Y; Suzuki, Y; De Andrade, V; De Carlo, F; Takekoshi, S; Inomoto, C; Nakamura, N; Torii, Y; Kushima, I; Iritani, S; Ozaki, N; Oshima, K; Itokawa, M; Arai, M

PLOS ONE   18 巻 ( 6 )   2023年6月

The clinical and molecular spectrum of the <i>KDM6B</i>-related neurodevelopmental disorder 査読有り

Rots, D; Jakub, TE; Keung, C; Lisenka, VELM; Banka, S; Pfundt, R; de Vries, BBA; van Jaarsveld, RH; Hopman, SMJ; van Binsbergen, E; Valenzuela, I; Hempel, M; Bierhals, T; Kortüm, F; Lecoquierre, F; Goldenberg, A; Hertz, JM; Andersen, CB; Kibaek, M; Prijoles, EJ; Stevenson, RE; Everman, DB; Patterson, WG; Meng, LY; Gijavanekar, C; De Dios, K; Lakhani, S; Levy, T; Wagner, M; Wieczorek, D; Benke, PJ; Garcia, MSL; Perrier, R; Sousa, SB; Almeida, PM; Simoes, MJ; Isidor, B; Deb, W; Schmanski, AA; Abdul-Rahman, O; Philippe, C; Bruel, AL; Faivre, L; Vitobello, A; Thauvin, C; Smits, JJ; Garavelli, L; Caraffi, SG; Peluso, F; Davis-Keppen, L; Platt, D; Royer, E; Leeuwen, L; Sinnema, M; Stegmann, APA; Stumpel, CTRM; Tiller, GE; Bosch, DSDLGM; Potgieter, ST; Joss, S; Splitt, M; Holden, S; Prapa, M; Foulds, N; Douzgou, S; Puura, K; Waltes, R; Chiocchetti, AG; Freitag, CM; Satterstrom, FK; De Rubeis, S; Buxbaum, J; Gelb, BD; Branko, A; Kushima, I; Howe, J; Scherer, SW; Arado, A; Baldo, C; Patat, O; Benedicte, D; Lopergolo, D; Santorelli, FM; Haack, TB; Dufke, A; Bertrand, M; Falb, RJ; Riess, A; Krieg, P; Spranger, S; Bedeschi, MF; Iascone, M; Josephi-Taylor, S; Roscioli, T; Buckley, MF; Liebelt, J; Dagli, AI; Aten, E; Hurst, ACE; Hicks, A; Suri, M; Aliu, E; Naik, S; Sidlow, R; Coursimault, J; Nicolas, G; Küpper, H; Petit, F; Ibrahim, V; Top, D; Di Cara, F; Louie, RJ; Stolerman, E; Brunner, HG; Vissers, LELM; Kramer, JM; Kleefstra, T

AMERICAN JOURNAL OF HUMAN GENETICS   110 巻 ( 6 ) 頁： 963 - 978   2023年6月

Clinical characterization of patients with schizophrenia and 16p13.11 duplication: A case series 査読有り

Kimura, H; Kushima, I; Banno, M; Inada, T; Yoshimi, A; Aleksic, B; Ozaki, N

NEUROPSYCHOPHARMACOLOGY REPORTS   43 巻 ( 2 ) 頁： 267 - 271   2023年6月

Astrotactin 2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems 査読有り

Ito, T; Yoshida, M; Aida, T; Kushima, I; Hiramatsu, Y; Ono, M; Yoshimi, A; Tanaka, K; Ozaki, N; Noda, Y

JOURNAL OF NEUROCHEMISTRY   165 巻 ( 2 ) 頁： 211 - 229   2023年4月

The genetic architecture of schizophrenia: review of large-scale genetic studies 査読有り

Kato, H; Kimura, H; Kushima, I; Takahashi, N; Aleksic, B; Ozaki, N

JOURNAL OF HUMAN GENETICS   68 巻 ( 3 ) 頁： 175 - 182   2023年3月

A case of bipolar disorder with <i>AIF1</i> (coding gene of Iba-1) deletion: A pilot <i>in vitro</i> analysis using blood-derived microglia-like cells 査読有り

Ohgidani, M; Kushima, I; Inamine, S; Kyuragi, S; Sagata, N; Nakao, T; Kanba, S; Ozaki, N; Kato, TA

PSYCHIATRY AND CLINICAL NEUROSCIENCES   77 巻 ( 2 ) 頁： 128 - 130   2023年2月

Clinical manifestations of schizophrenia in four patients with variants in voltage-gated calcium channel-encoding genes: a case series 査読有り

Lo, TY; Kushima, I; Aleksic, B; Yoshimi, A; Someya, T; Watanabe, Y; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   77 巻 ( 1 ) 頁： 57 - 59   2023年1月

X chromosome aneuploidies and schizophrenia: association analysis and phenotypic characterization 査読有り

Kushima, I; Aleksic, B; Kimura, H; Nakatochi, M; Lo, T; Ikeda, M; Arai, M; Hashimoto, R; Numata, S; Okamura, Y; Obara, T; Inada, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 12 ) 頁： 667 - 673   2022年12月

Turner syndrome presenting with idiopathic regression: A case report 査読有り

Mizobuchi, K; Kushima, I; Kato, H; Miyajima, M; Kimura, H; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 12 ) 頁： 680 - 682   2022年12月

Establishment of induced pluripotent stem cells from a patient with 16p13.11 duplication and VPS13B deletion 査読有り

Okumura, H; Arioka, Y; Kushima, I; Mori, D; Ozaki, N

STEM CELL RESEARCH   64 巻   2022年10月

Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder 査読有り

Kushima, I; Nakatochi, M; Aleksic, B; Okada, T; Kimura, H; Kato, H; Morikawa, M; Inada, T; Ishizuka, K; Torii, Y; Nakamura, Y; Tanaka, S; Imaeda, M; Takahashi, N; Yamamoto, M; Iwamoto, K; Nawa, Y; Ogawa, N; Iritani, S; Hayashi, Y; Lo, TY; Otgonbayar, G; Furuta, S; Iwata, N; Ikeda, M; Saito, T; Ninomiya, K; Okochi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Fujimoto, M; Miura, K; Itokawa, M; Arai, M; Miyashita, M; Toriumi, K; Ohi, K; Shioiri, T; Kitaichi, K; Someya, T; Watanabe, Y; Egawa, J; Takahashi, T; Suzuki, M; Sasaki, T; Tochigi, M; Nishimura, F; Yamasue, H; Kuwabara, H; Wakuda, T; Kato, TA; Kanba, S; Horikawa, H; Usami, M; Kodaira, M; Watanabe, K; Yoshikawa, T; Toyota, T; Yokoyama, S; Munesue, T; Kimura, R; Funabiki, Y; Kosaka, H; Jung, MY; Kasai, K; Ikegame, T; Jinde, S; Numata, S; Kinoshita, M; Kato, T; Kakiuchi, C; Yamakawa, K; Suzuki, T; Hashimoto, N; Ishikawa, S; Yamagata, B; Nio, S; Murai, T; Son, S; Kunii, Y; Yabe, H; Inagaki, M; Goto, Y; Okumura, Y; Ito, T; Arioka, Y; Mori, D; Ozaki, N

BIOLOGICAL PSYCHIATRY   92 巻 ( 5 ) 頁： 362 - 374   2022年9月

Contribution of copy number variations to the risk of severe eating disorders 査読有り

Kushima, I; Imaeda, M; Tanaka, S; Kato, H; Oya-Ito, T; Nakatochi, M; Aleksic, B; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 9 ) 頁： 423 - 428   2022年9月

Rare coding variation provides insight into the genetic architecture and phenotypic context of autism 招待有り 査読有り

Nature Genetics     2022年9月

Case series of four psychiatric patients with copy number variations in the neurexin 1 gene

Kushima, I; Inada, T; Ohi, K; Egawa, J; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES REPORTS   1 巻 ( 3 )   2022年9月

Exome sequencing analysis of Japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes 査読有り

Kimura, H; Nakatochi, M; Aleksic, B; Guevara, J; Toyama, M; Hayashi, Y; Kato, H; Kushima, I; Morikawa, M; Ishizuka, K; Okada, T; Tsurusaki, Y; Fujita, A; Miyake, N; Ogi, T; Takata, A; Matsumoto, N; Buxbaum, J; Ozaki, N; Sebat, J

TRANSLATIONAL PSYCHIATRY   12 巻 ( 1 )   2022年7月

Exonic deletions in <i>IMMP2L</i> in schizophrenia with enhanced glycation stress subtype

Yoshikawa, A; Kushima, I; Miyashita, M; Suzuki, K; Iino, K; Toriumi, K; Horiuchi, Y; Kawaji, H; Ozaki, N; Itokawa, M; Arai, M

PLOS ONE   17 巻 ( 7 )   2022年7月

Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients 査読有り

Nawa, Y; Kushima, I; Aleksic, B; Yamamoto, M; Kimura, H; Banno, M; Hashimoto, R; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 7 ) 頁： 338 - 339   2022年7月

Psychiatric patients with a <i>de novo</i> 17q12 deletion: Two case reports 査読有り

Kushima, I; Uematsu, M; Ishizuka, K; Aleksic, B; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 7 ) 頁： 345 - 347   2022年7月

Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia

Chen, CH; Cheng, MC; Hu, TM; Ping, LY; Kushima, I; Aleksic, B

PSYCHIATRIC GENETICS   32 巻 ( 3 ) 頁： 125 - 130   2022年6月

Investigation of<i> OLIG2</i> as a candidate gene for schizophrenia and autism spectrum disorder

Furuta, S; Aleksic, B; Nawa, Y; Kimura, H; Kushima, I; Ishizuka, K; Kato, H; Toyama, M; Arioka, Y; Mori, D; Morikawa, M; Inada, T; Ozaki, N

NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 2 ) 頁： 260 - 268   2022年5月

Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial

Yamasue, H; Kojima, M; Kuwabara, H; Kuroda, M; Matsumoto, K; Kanai, C; Inada, N; Owada, K; Ochi, K; Ono, N; Benner, S; Wakuda, T; Kameno, Y; Inoue, J; Harada, T; Tsuchiya, K; Umemura, K; Yamauchi, A; Ogawa, N; Kushima, I; Ozaki, N; Suyama, S; Saito, T; Uemura, Y; Hamada, J; Kano, Y; Honda, N; Kikuchi, S; Seto, M; Tomita, H; Miyoshi, N; Matsumoto, M; Kawaguchi, Y; Kanai, K; Ikeda, M; Nakamura, I; Isomura, S; Hirano, Y; Onitsuka, T; Kosaka, H; Okada, T

BRAIN   145 巻 ( 2 ) 頁： 490 - 499   2022年4月

Case report of a female with bipolar disorder and <i>MBD5</i> deletion

Kushima, I; Lo, T; Aleksic, B; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 4 ) 頁： 127 - 128   2022年4月

Variable psychiatric manifestations in patients with 16p11.2 duplication: a case series of 4 patients. 査読有り

Psychiatry Clin Neurosci.     2022年3月

Variable psychiatric manifestations in patients with 16p11.2 duplication: a case series of 4 patients

Hayashi, Y; Kushima, I; Aleksic, B; Senaha, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 3 ) 頁： 86 - 88   2022年3月

Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder

Wang, CY; Horigane, S; Wakamori, M; Ueda, S; Kawabata, T; Fujii, H; Kushima, I; Kimura, H; Ishizuka, K; Nakamura, Y; Iwayama, Y; Ikeda, M; Iwata, N; Okada, T; Aleksic, B; Mori, D; Yoshida, T; Bito, H; Yoshikawa, T; Takemoto-Kimura, S; Ozaki, N

TRANSLATIONAL PSYCHIATRY   12 巻 ( 1 )   2022年2月

Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population

Lo, T; Kushima, I; Aleksic, B; Kato, H; Nawa, Y; Hayashi, Y; Otgonbayar, G; Kimura, H; Arioka, Y; Mori, D; Ozaki, N

INTERNATIONAL REVIEW OF PSYCHIATRY   34 巻 ( 2 ) 頁： 154 - 167   2022年2月

Autism spectrum disorder comorbid with obsessive compulsive disorder and eating disorder in a woman with <i>NBEA</i> deletion

Kato, H; Kushima, I; Yoshimi, A; Ishizuka, K; Kimura, H; Aleksic, B; Takahashi, N; Okada, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 1 ) 頁： 36 - 38   2022年1月

Trends in big data analyses by multicenter collaborative translational research in psychiatry

Onitsuka, T; Hirano, Y; Nemoto, K; Hashimoto, N; Kushima, I; Koshiyama, D; Koeda, M; Takahashi, T; Noda, Y; Matsumoto, J; Miura, K; Nakazawa, T; Hikida, T; Kasai, K; Ozaki, N; Hashimoto, R

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 1 ) 頁： 1 - 14   2022年1月

Case report of a female with bipolar disorder and MBD5 deletion. 査読有り

Psychiatry Clin Neurosci.     2022年

Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. 査読有り

Transl Psychiatry     2022年

Cross-disorder analysis of genic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder 査読有り

Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii, Yukako Nakamura, Satoshi Tanaka, Miho Imaeda, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Nanayo Ogawa, Shuji Iritani, Yu Hayashi, Tzuyao Lo, Gantsooj Otgonbayar, Sho Furuta, Nakao Iwata, Masashi Ikeda, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Tsukasa Sasaki, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Hitoshi Kuwabara, Tomoyasu Wakuda, Takahiro A. Kato, Shigenobu Kanba, Hideki Horikawa, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Takeo Yoshikawa, Tomoko Toyota, Shigeru Yokoyama, Toshio Munesue, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Minyoung Jung, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Shusuke Numata, Makoto Kinoshita, Tadafumi Kato, Chihiro Kakiuchi, Kazuhiro Yamakawa, Toshimitsu Suzuki, Naoki Hashimoto, Shuhei Ishikawa, Bun Yamagata, Shintaro Nio, Toshiya Murai, Shuraku Son, Yasuto Kunii, Hirooki Yabe, Masumi Inagaki, Yu-ichi Goto, Yuto Okumura, Tomoya Ito, Yuko Arioka, Daisuke Mori, Norio Ozaki

Biological Psychiatry     2022年

Exome sequencing of Japanese schizophrenia multiplex families supports the involvement of calcium ion channels

Toyama, M; Takasaki, Y; Branko, A; Kimura, H; Kato, H; Nawa, Y; Kushima, I; Ishizuka, K; Shimamura, T; Ogi, T; Ozaki, N

PLOS ONE   17 巻 ( 5 )   2022年

<i>AKR1A1</i> Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity

Iino, K; Toriumi, K; Agarie, R; Miyashita, M; Suzuki, K; Horiuchi, Y; Niizato, K; Oshima, K; Imai, A; Nagase, Y; Kushima, I; Koike, S; Ikegame, T; Jinde, S; Nagata, E; Washizuka, S; Miyata, T; Takizawa, S; Hashimoto, R; Kasai, K; Ozaki, N; Itokawa, M; Arai, M

FRONTIERS IN GENETICS   12 巻   2021年12月

Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures

Saiga, R; Uesugi, M; Takeuchi, A; Uesugi, K; Suzuki, Y; Takekoshi, S; Inomoto, C; Nakamura, N; Torii, Y; Kushima, I; Iritani, S; Ozaki, N; Oshima, K; Itokawa, M; Arai, M; Mizutani, R

SCIENTIFIC REPORTS   11 巻 ( 1 )   2021年6月

Dysregulation of post-transcriptional modification by copy number variable microRNAs in schizophrenia with enhanced glycation stress

Yoshikawa, A; Kushima, I; Miyashita, M; Toriumi, K; Suzuki, K; Horiuchi, Y; Kawaji, H; Takizawa, S; Ozaki, N; Itokawa, M; Arai, M

TRANSLATIONAL PSYCHIATRY   11 巻 ( 1 )   2021年5月

Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders

Saito, R; Miyoshi, C; Koebis, M; Kushima, I; Nakao, K; Mori, D; Ozaki, N; Funato, H; Yanagisawa, M; Aiba, A

MOLECULAR BRAIN   14 巻 ( 1 )   2021年4月

Resequencing and association analysis of <i>GAP43</i> with autism spectrum disorder and schizophrenia in a Japanese population 査読有り

Arta, RK; Watanabe, Y; Inoue, E; Nawa, Y; Morikawa, R; Egawa, J; Kushima, I; Igeta, H; Hoya, S; Sugimoto, A; Tanra, AJ; Ozaki, N; Someya, T

RESEARCH IN AUTISM SPECTRUM DISORDERS   82 巻   2021年4月

Mice carrying a schizophrenia-associated mutation of the <i>Arhgap10</i> gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons 査読有り

Hada, K; Wulaer, B; Nagai, T; Itoh, N; Sawahata, M; Sobue, A; Mizoguchi, H; Mori, D; Kushima, I; Nabeshima, T; Ozaki, N; Yamada, K

MOLECULAR BRAIN   14 巻 ( 1 )   2021年1月

Structural diverseness of neurons between brain areas and between cases 査読有り

Mizutani, R; Saiga, R; Yamamoto, Y; Uesugi, M; Takeuchi, A; Uesugi, K; Terada, Y; Suzuki, Y; De Andrade, V; De Carlo, F; Takekoshi, S; Inomoto, C; Nakamura, N; Torii, Y; Kushima, I; Iritani, S; Ozaki, N; Oshima, K; Itokawa, M; Arai, M

TRANSLATIONAL PSYCHIATRY   11 巻 ( 1 )   2021年1月

Implications of germline copy-number variations in psychiatric disorders: review of large-scale genetic studies 査読有り

Nakatochi, M; Kushima, I; Ozaki, N

JOURNAL OF HUMAN GENETICS   66 巻 ( 1 ) 頁： 25 - 37   2021年1月

Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons 査読有り

Arioka, Y; Shishido, E; Kushima, I; Suzuki, T; Saito, R; Aiba, A; Mori, D; Ozaki, N

EBIOMEDICINE   63 巻   2021年1月

Rare genetic variants in the gene encoding histone lysine demethylase 4C (<i>KDM4C</i>) and their contributions to susceptibility to schizophrenia and autism spectrum disorder 査読有り

Kato, H; Kushima, I; Mori, D; Yoshimi, A; Aleksic, B; Nawa, Y; Toyama, M; Furuta, S; Yu, YJ; Ishizuka, K; Kimura, H; Arioka, Y; Tsujimura, K; Morikawa, M; Okada, T; Inada, T; Nakatochi, M; Shinjo, K; Kondo, Y; Kaibuchi, K; Funabiki, Y; Kimura, R; Suzuki, T; Yamakawa, K; Ikeda, M; Iwata, N; Takahashi, T; Suzuki, M; Okahisa, Y; Takaki, M; Egawa, J; Someya, T; Ozaki, N

TRANSLATIONAL PSYCHIATRY   10 巻 ( 1 )   2020年12月

Involvement of nicotinic acetylcholine receptors in behavioral abnormalities and psychological dependence in schizophrenia-like model mice 査読有り

Noda, Y; Uchida, M; Mouri, A; Yamada, S; Goto, S; Kitagaki, S; Mamiya, T; Kushima, I; Arioka, Y; Ozaki, N; Yoshimi, A

EUROPEAN NEUROPSYCHOPHARMACOLOGY   41 巻   頁： 92 - 105   2020年12月

Support vector machine-based classification of schizophrenia patients and healthy controls using structural magnetic resonance imaging from two independent sites 査読有り

Yamamoto, M; Bagarinao, E; Kushima, I; Takahashi, T; Sasabayashi, D; Inada, T; Suzuki, M; Iidaka, T; Ozaki, N

PLOS ONE   15 巻 ( 11 )   2020年11月

Rare single-nucleotide <i>DAB1</i> variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility 査読有り

Nawa, Y; Kimura, H; Mori, D; Kato, H; Toyama, M; Furuta, S; Yu, YJ; Ishizuka, K; Kushima, I; Aleksic, B; Arioka, Y; Morikawa, M; Okada, T; Inada, T; Kaibuchi, K; Ikeda, M; Iwata, N; Suzuki, M; Okahisa, Y; Egawa, J; Someya, T; Nishimura, F; Sasaki, T; Ozaki, N

HUMAN GENOME VARIATION   7 巻 ( 1 )   2020年11月

Functional characterization of rare <i>NRXN1</i> variants identified in autism spectrum disorders and schizophrenia 査読有り

Ishizuka, K; Yoshida, T; Kawabata, T; Imai, A; Mori, H; Kimura, H; Inada, T; Okahisa, Y; Egawa, J; Usami, M; Kushima, I; Morikawa, M; Okada, T; Ikeda, M; Branko, A; Mori, D; Someya, T; Iwata, N; Ozaki, N

JOURNAL OF NEURODEVELOPMENTAL DISORDERS   12 巻 ( 1 )   2020年9月

The accumulation of advanced glycation end-products in a schizophrenic patient with a glyoxalase 1 frameshift mutation: An autopsy study 査読有り

Torii, Y; Iritani, S; Sekiguchi, H; Habuchi, C; Fujishiro, H; Kushima, I; Kawakami, I; Itokawa, M; Arai, M; Hayashida, S; Masaki, K; Kira, J; Kawashima, K; Ozaki, N

SCHIZOPHRENIA RESEARCH   223 巻   頁： 356 - 358   2020年9月

Morphological alteration of myelin-oligodendrocytes in a schizophrenic patient with 22q11.2 deletion syndrome: An autopsy study

Torii, Y; Iritani, S; Marui, T; Sekiguchi, H; Habuchi, C; Fujishiro, H; Kushima, I; Oshima, K; Niizato, K; Hayashida, S; Masaki, K; Kira, J; Yoshida, M; Ozaki, N

SCHIZOPHRENIA RESEARCH   223 巻   頁： 353 - 355   2020年9月

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial 査読有り

Yamasue, H; Okada, T; Munesue, T; Kuroda, M; Fujioka, T; Uno, Y; Matsumoto, K; Kuwabara, H; Mori, D; Okamoto, Y; Yoshimura, Y; Kawakubo, Y; Arioka, Y; Kojima, M; Yuhi, T; Owada, K; Yassin, W; Kushima, I; Benner, S; Ogawa, N; Eriguchi, Y; Kawano, N; Uemura, Y; Yamamoto, M; Kano, Y; Kasai, K; Higashida, H; Ozaki, N; Kosaka, H

MOLECULAR PSYCHIATRY   25 巻 ( 8 ) 頁： 1849 - 1858   2020年8月

<i>ARHGAP10</i>, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk 査読有り

Sekiguchi, M; Sobue, A; Kushima, I; Wang, CY; Arioka, Y; Kato, H; Kodama, A; Kubo, H; Ito, N; Sawahata, M; Hada, K; Ikeda, R; Shinno, M; Mizukoshi, C; Tsujimura, K; Yoshimi, A; Ishizuka, K; Takasaki, Y; Kimura, H; Xing, JR; Yu, YJ; Yamamoto, M; Okada, T; Shishido, E; Inada, T; Nakatochi, M; Takano, T; Kuroda, K; Amano, M; Aleksic, B; Yamomoto, T; Sakuma, T; Aida, T; Tanaka, K; Hashimoto, R; Arai, M; Ikeda, M; Iwata, N; Shimamura, T; Nagai, T; Nabeshima, T; Kaibuchi, K; Yamada, K; Mori, D; Ozaki, N

TRANSLATIONAL PSYCHIATRY   10 巻 ( 1 )   2020年7月

A recurrent<i>PJA1</i>variant in trigonocephaly and neurodevelopmental disorders 査読有り

Suzuki, T; Suzuki, T; Raveau, M; Miyake, N; Sudo, G; Tsurusaki, Y; Watanabe, T; Sugaya, Y; Tatsukawa, T; Mazaki, E; Shimohata, A; Kushima, I; Aleksic, B; Shiino, T; Toyota, T; Iwayama, Y; Nakaoka, K; Ohmori, I; Sasaki, A; Watanabe, K; Hirose, S; Kaneko, S; Inoue, Y; Yoshikawa, T; Ozaki, N; Kano, M; Shimoji, T; Matsumoto, N; Yamakawa, K

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY   7 巻 ( 7 ) 頁： 1117 - 1131   2020年7月

Generation and analysis of novel <i>Reln-</i>deleted mouse model corresponding to exonic <i>Reln</i> deletion in schizophrenia 査読有り

Sawahata, M; Mori, D; Arioka, Y; Kubo, H; Kushima, I; Kitagawa, K; Sobue, A; Shishido, E; Sekiguchi, M; Kodama, A; Ikeda, R; Aleksic, B; Kimura, H; Ishizuka, K; Nagai, T; Kaibuchi, K; Nabeshima, T; Yamada, K; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   74 巻 ( 5 ) 頁： 318 - 327   2020年5月

Cell body shape and directional movement stability in human-induced pluripotent stem cell-derived dopaminergic neurons 査読有り

Arioka, Y; Shishido, E; Kushima, I; Mori, D; Ozaki, N

SCIENTIFIC REPORTS   10 巻 ( 1 )   2020年4月

Cutting-edge morphological studies of post-mortem brains of patients with schizophrenia and potential applications of X-ray nanotomography (nano-CT)

Itokawa, M; Oshima, K; Arai, M; Torii, Y; Kushima, I; Iritani, S; Ozaki, N; Saiga, R; Mizutani, R

PSYCHIATRY AND CLINICAL NEUROSCIENCES   74 巻 ( 3 ) 頁： 176 - 182   2020年3月

Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus

Saito, R; Koebis, M; Nagai, T; Shimizu, K; Liao, J; Wulaer, B; Sugaya, Y; Nagahama, K; Uesaka, N; Kushima, I; Mori, D; Maruyama, K; Nakao, K; Kurihara, H; Yamada, K; Kano, M; Fukada, Y; Ozaki, N; Aiba, A

TRANSLATIONAL PSYCHIATRY   10 巻 ( 1 )   2020年2月

Characterization of a schizophrenia patient with a rare <i>RELN</i> deletion by combining genomic and patient-derived cell analyses

Arioka, Y; Hirata, A; Kushima, I; Aleksic, B; Mori, D; Ozaki, N

SCHIZOPHRENIA RESEARCH   216 巻   頁： 511 - 515   2020年2月

Polygenic risk scores in schizophrenia with clinically significant copy number variants

Taniguchi, S; Ninomiya, K; Kushima, I; Saito, T; Shimasaki, A; Sakusabe, T; Momozawa, Y; Kubo, M; Kamatani, Y; Ozaki, N; Ikeda, M; Iwata, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   74 巻 ( 1 ) 頁： 35 - 39   2020年1月

A network of networks approach for modeling interconnected brain tissue-specific networks

Kawakubo, H; Matsui, Y; Kushima, I; Ozaki, N; Shimamura, T

BIOINFORMATICS   35 巻 ( 17 ) 頁： 3092 - 3101   2019年9月

<i>In Vitro</i> Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of <i>PCDH15</i> and <i>RELN</i>

Ishii, T; Ishikawa, M; Fujimori, K; Maeda, T; Kushima, I; Arioka, Y; Mori, D; Nakatake, Y; Yamagata, B; Nio, S; Kato, TA; Yang, N; Wernig, M; Kanba, S; Mimura, M; Ozaki, N; Okano, H

ENEURO   6 巻 ( 5 )   2019年9月

Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect

Ikeda, M; Takahashi, A; Kamatanim, Y; Momozawa, Y; Saito, T; Kondo, K; Shimasaki, A; Kawase, K; Sakusabe, T; Iwayama, Y; Toyota, T; Wakudas, T; Kikuchi, M; Kanahara, N; Yamamori, H; Yasuda, Y; Watanabe, Y; Hoya, S; Aleksic, B; Kushima, I; Arai, H; Takaki, M; Hattori, K; Kurrugi, H; Okahisa, Y; Ohnuma, T; Ozaki, N; Someya, T; Hashimotovs, R; Yoshikawa, T; Kubo, M; Iwata, N

SCHIZOPHRENIA BULLETIN   45 巻 ( 4 ) 頁： 824 - 834   2019年7月

Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism

Owada, K; Okada, T; Munesue, T; Kuroda, M; Fujioka, T; Uno, Y; Matsumoto, K; Kuwabara, H; Mori, D; Okamoto, Y; Yoshimura, Y; Kawakubo, Y; Arioka, Y; Kojima, M; Yuhi, T; Yassin, W; Kushima, I; Benner, S; Ogawa, N; Kawano, N; Eriguchi, Y; Uemura, Y; Yamamoto, M; Kano, Y; Kasai, K; Higashida, H; Ozaki, N; Kosaka, H; Yamasue, H

BRAIN   142 巻   頁： 2127 - 2136   2019年7月

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients

Yoshimi, A; Yamada, S; Kunimoto, S; Aleksic, B; Hirakawa, A; Ohashi, M; Matsumoto, Y; Hada, K; Itoh, N; Arioka, Y; Kimura, H; Kushima, I; Nakamura, Y; Shiino, T; Mori, D; Tanaka, S; Hamada, S; Noda, Y; Nagai, T; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY   9 巻   2019年4月

Three-dimensional alteration of neurites in schizophrenia

Mizutani, R; Saiga, R; Takeuchi, A; Uesugi, K; Terada, Y; Suzuki, Y; De Andrade, V; De Carlo, F; Takekoshi, S; Inomoto, C; Nakamura, N; Kushima, I; Iritani, S; Ozaki, N; Ide, S; Ikeda, K; Oshima, K; Itokawa, M; Arai, M

TRANSLATIONAL PSYCHIATRY   9 巻   2019年2月

A NOVEL RARE VARIANT R292H IN RTN4R AFFECTS GROWTH CONE FORMATION AND POSSIBLY CONTRIBUTES TO SCHIZOPHRENIA SUSCEPTIBILITY

Kimura, H; Ishizuka, K; Wang, CY; Kushima, I; Morikawa, M; Uno, Y; Okada, T; Inanda, T; Aleksic, B; Mori, D; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY   29 巻   頁： S1014 - S1014   2019年

Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability

Kunisawa, K; Shimizu, T; Kushima, I; Aleksic, B; Mori, D; Osanai, Y; Kobayashi, K; Taylor, AM; Bhat, MA; Hayashi, A; Baba, H; Ozaki, N; Ikenaka, K

JOURNAL OF NEUROCHEMISTRY   147 巻 ( 3 ) 頁： 395 - 408   2018年11月

Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia

Ishizuka, K; Kimura, H; Kushima, I; Inada, T; Okahisa, Y; Ikeda, M; Iwata, N; Mori, D; Aleksic, B; Ozaki, N

PSYCHIATRIC GENETICS   28 巻 ( 5 ) 頁： 90 - 93   2018年10月

Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights 査読有り

Kushima, I; Aleksic, B; Nakatochi, M; Shimamura, T; Okada, T; Uno, Y; Morikawa, M; Ishizuka, K; Shiino, T; Kimura, H; Arioka, Y; Yoshimi, A; Takasaki, Y; Yu, Y; Nakamura, Y; Yamamoto, M; Iidaka, T; Iritani, S; Inada, T; Ogawa, N; Shishido, E; Torii, Y; Kawano, N; Omura, Y; Yoshikawa, T; Uchiyama, T; Yamamoto, T; Ikeda, M; Hashimoto, R; Yamamori, H; Yasuda, Y; Someya, T; Watanabe, Y; Egawa, J; Nunokawa, A; Itokawa, M; Arai, M; Miyashita, M; Kobori, A; Suzuki, M; Takahashi, T; Usami, M; Kodaira, M; Watanabe, K; Sasaki, T; Kuwabara, H; Tochigi, M; Nishimura, F; Yamasue, H; Eriguchi, Y; Benner, S; Kojima, M; Yassin, W; Munesue, T; Yokoyama, S; Kimura, R; Funabiki, Y; Kosaka, H; Ishitobi, M; Ohmori, T; Numata, S; Yoshikawa, T; Toyota, T; Yamakawa, K; Suzuki, T; Inoue, Y; Nakaoka, K; Goto, YI; Inagaki, M; Hashimoto, N; Kusumi, I; Son, S; Murai, T; Ikegame, T; Okada, N; Kasai, K; Kunimoto, S; Mori, D; Iwata, N; Ozaki, N

CELL REPORTS   24 巻 ( 11 ) 頁： 2838 - 2856   2018年9月

Aberrant functional connectivity between the thalamus and visual cortex is related to attentional impairment in schizophrenia

Yamamoto, M; Kushima, I; Suzuki, R; Branko, A; Kawano, N; Inada, T; Iidaka, T; Ozaki, N

PSYCHIATRY RESEARCH-NEUROIMAGING   278 巻   頁： 35 - 41   2018年8月

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of <i>RELN</i> in schizophrenia

Sobue, A; Kushima, I; Nagai, T; Shan, W; Kohno, T; Aleksic, B; Aoyama, Y; Mori, D; Arioka, Y; Kawano, N; Yamamoto, M; Hattori, M; Nabeshima, T; Yamada, K; Ozaki, N

SCIENTIFIC REPORTS   8 巻   2018年8月

Three lines of induced pluripotent stem cells derived from a 15q11.2-q13.1 duplication syndrome patient

Arioka, Y; Kushima, I; Mori, D; Ozaki, N

STEM CELL RESEARCH   31 巻   頁： 240 - 243   2018年8月

Single-cell trajectory analysis of human homogenous neurons carrying a rare <i>RELN</i> variant

Arioka, Y; Shishido, E; Kubo, H; Kushima, I; Yoshimi, A; Kimura, H; Ishizuka, K; Aleksic, B; Maeda, T; Ishikawa, M; Kuzumaki, N; Okano, H; Mori, D; Ozaki, N

TRANSLATIONAL PSYCHIATRY   8 巻   2018年7月

Induced pluripotent stem cells derived from a schizophrenia patient with <i>ASTN2</i> deletion

Arioka, Y; Kushima, I; Kubo, H; Mori, D; Ozaki, N

STEM CELL RESEARCH   30 巻   頁： 81 - 84   2018年7月

Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion. 査読有り

Arioka Y, Kushima I, Kubo H, Mori D, Ozaki N.

Stem Cell Res.     2018年5月

Integrative Analyses of <i>De Novo</i> Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder

Takata, A; Miyake, N; Tsurusaki, Y; Fukai, R; Miyatake, S; Koshimizu, E; Kushima, I; Okada, T; Morikawa, M; Uno, Y; Ishizuka, K; Nakamura, K; Tsujii, M; Yoshikawa, T; Toyota, T; Okamoto, N; Hiraki, Y; Hashimoto, R; Yasuda, Y; Saitoh, S; Ohashi, K; Sakai, Y; Ohga, S; Hara, T; Kato, M; Nakamura, K; Ito, A; Seiwa, C; Shirahata, E; Osaka, H; Matsumoto, A; Takeshita, S; Tohyama, J; Saikusa, T; Matsuishi, T; Nakamura, T; Tsuboi, T; Kato, T; Suzuki, T; Saitsu, H; Nakashima, M; Mizuguchi, T; Tanaka, F; Mori, N; Ozaki, N; Matsumoto, N

CELL REPORTS   22 巻 ( 3 ) 頁： 734 - 747   2018年1月

Rare loss of function mutations in <i>N</i>-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility

Yu, YJ; Lin, YN; Takasaki, Y; Wang, CY; Kimura, H; Xing, JR; Ishizuka, K; Toyama, M; Kushima, I; Mori, D; Arioka, Y; Uno, Y; Shiino, T; Nakamura, Y; Okada, T; Morikawa, M; Ikeda, M; Iwata, N; Okahisa, Y; Takaki, M; Sakamoto, S; Someya, T; Egawa, J; Usami, M; Kodaira, M; Yoshimi, A; Oya-Ito, T; Aleksic, B; Ohno, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY   8 巻   2018年1月

IDENTIFICATION OF RARE DISRUPTIVE VARIANTS IN VOLTAGE-GATED CHANNEL GENES (CACNA1C, CACNA1D, CACNA1S, CACNA1I) IN JAPANESE SAMPLES OF SCHIZOPHRENIA AND AUTISM SPECTRUM DISORDER USING ION TORRENT PGM PLATFORM

Wang, C; Kimura, H; Xing, J; Ishizuka, K; Kushima, I; Arioka, Y; Yoshimi, A; Nakamura, Y; Shiino, Y; Oya, Y; Takasaki, Y; Aleksic, B; Mori, D; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY   27 巻   頁： S341 - S342   2017年10月

MUTATION SCREENING OF THE PCDH15 GENE IN PATIENTS SUFFERING FROM AUTISM SPECTRUM DISORDERS AND SCHIZOPHRENIA

Ishizuka, K; Wang, CY; Kimura, H; Xing, JR; Kushima, I; Arioka, Y; Yoshimi, A; Nakamura, Y; Oya-Ito, T; Takasaki, Y; Uno, Y; Okada, T; Mori, D; Aleksic, B; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY   27 巻   頁： S162 - S163   2017年10月

Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder

Lim, ET; Uddin, M; De Rubeis, S; Chan, Y; Kamumbu, AS; Zhang, XC; D'Gama, AM; Kim, SN; Hill, RS; Goldberg, AP; Poultney, C; Minshew, NJ; Kushima, I; Aleksic, B; Ozaki, N; Parellada, M; Arango, C; Penzol, MJ; Carracedo, A; Kolevzon, A; Hultman, CM; Weiss, LA; Fromer, M; Chiocchetti, AG; Freitag, CM; Church, GM; Scherer, SW; Buxbaum, JD; Walsh, CA

NATURE NEUROSCIENCE   20 巻 ( 9 ) 頁： 1217 - +   2017年9月

A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility

Kimura, H; Fujita, Y; Kawabata, T; Ishizuka, K; Wang, C; Iwayama, Y; Okahisa, Y; Kushima, I; Morikawa, M; Uno, Y; Okada, T; Ikeda, M; Inada, T; Branko, A; Mori, D; Yoshikawa, T; Iwata, N; Nakamura, H; Yamashita, T; Ozaki, N

TRANSLATIONAL PSYCHIATRY   7 巻   2017年8月

Rare genetic variants in <i>CX3CR1</i> and their contribution to the increased risk of schizophrenia and autism spectrum disorders

Ishizuka, K; Fujita, Y; Kawabata, T; Kimura, H; Iwayama, Y; Inada, T; Okahisa, Y; Egawa, J; Usami, M; Kushima, I; Uno, Y; Okada, T; Ikeda, M; Aleksic, B; Mori, D; Someya, T; Yoshikawa, T; Iwata, N; Nakamura, H; Yamashita, T; Ozaki, N

TRANSLATIONAL PSYCHIATRY   7 巻   2017年8月

High-resolution copy number variation analysis of schizophrenia in Japan 査読有り

Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T, Miyashita M, Kobori A, Arai M, Itokawa M, Cheng MC, Chuang YA, Chen CH, Suzuki M, Takahashi T, Hashimoto R, Yamamori H, Yasuda Y, Watanabe Y, Nunokawa A, Someya T, Ikeda M, Toyota T, Yoshikawa T, Numata S, Ohmori T, Kunimoto S, Mori D, Iwata N, Ozaki N.

Molecular Psychiatry   22 巻 ( 3 ) 頁： 430-440   2017年3月

High-resolution copy number variation analysis of schizophrenia in Japan

Kushima, I; Aleksic, B; Nakatochi, M; Shimamura, T; Shiino, T; Yoshimi, A; Kimura, H; Takasaki, Y; Wang, C; Xing, J; Ishizuka, K; Oya-Ito, T; Nakamura, Y; Arioka, Y; Maeda, T; Yamamoto, M; Yoshida, M; Noma, H; Hamada, S; Morikawa, M; Uno, Y; Okada, T; Iidaka, T; Iritani, S; Yamamoto, T; Miyashita, M; Kobori, A; Arai, M; Itokawa, M; Cheng, MC; Chuang, YA; Chen, CH; Suzuki, M; Takahashi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Watanabe, Y; Nunokawa, A; Someya, T; Ikeda, M; Toyota, T; Yoshikawa, T; Numata, S; Ohmori, T; Kunimoto, S; Mori, D; Iwata, N; Ozaki, N

MOLECULAR PSYCHIATRY   22 巻 ( 3 ) 頁： 430 - 440   2017年3月

Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility. 査読有り

Kimura H, Kushima I, Yohimi A, Aleksic B, Ozaki N.

Int J Neuropsychopharmacol.     2017年

Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders. 査読有り

Ishizuka K, Tabata H, Ito H, Kushima I, Noda M, Yoshimi A, Usami M, Watanabe K, Morikawa M, Uno Y, Okada T, Mori D, Aleksic B, Ozaki N, Nagata KI.

J Neurosci Res.     2017年

Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders. 査読有り

Isles AR, Ingason A, Lowther C, Walters J, Gawlick M, Stöber G, Rees E, Martin J, Little RB, Potter H, Georgieva L, Pizzo L, Ozaki N, Aleksic B, Kushima I, Ikeda M, Iwata N, Levinson DF, Gejman PV, Shi J, Sanders AR, Duan J, Willis J, Sisodiya S, Costain G, Werge TM, Degenhardt F, Giegling I, Rujescu D, Hreidarsson SJ, Saemundsen E, Ahn JW, Ogilvie C, Girirajan SD, Stefansson H, Stefansson K, O'Donovan MC, Owen MJ, Bassett A, Kirov G.

PLoS Genet.   12 巻 ( 5 ) 頁： e1005993   2016年5月

Contribution of autosomal rare and de novo variants to sex differences in autism 査読有り 国際共著

Mahmoud Koko, F Kyle Satterstrom; Autism Sequencing Consortium; APEX consortium; Varun Warrier, Hilary Martin

Am J Hum Genet   112 巻 ( 3 ) 頁： 599 - 614   2025年3月

Association Analysis of Rare <i>CNTN5</i> Variants With Autism Spectrum Disorder in a Japanese Population 査読有り

Hadi, AF; Arta, RK; Kushima, I; Egawa, J; Watanabe, Y; Ozaki, N; Someya, T

NEUROPSYCHOPHARMACOLOGY REPORTS   45 巻 ( 1 )   2025年3月

Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data-Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders 査読有り

Yasuda, Y; Ito, S; Matsumoto, J; Okada, N; Onitsuka, T; Ikeda, M; Kushima, I; Sumiyoshi, C; Fukunaga, M; Nemoto, K; Miura, K; Hashimoto, N; Ohi, K; Takahashi, T; Sasabayashi, D; Koeda, M; Yamamori, H; Fujimoto, M; Takano, H; Hasegawa, N; Narita, H; Yamamoto, M; Tha, KK; Kikuchi, M; Kamishikiryo, T; Itai, E; Okubo, Y; Tateno, A; Nakamura, M; Kubota, M; Igarashi, H; Hirano, Y; Okada, G; Miyata, J; Numata, S; Abe, O; Yoshimura, R; Nakagawa, S; Yamasue, H; Ozaki, N; Kasai, K; Hashimoto, R

NEUROPSYCHOPHARMACOLOGY REPORTS   45 巻 ( 1 )   2025年3月

Molecular diagnosis of 405 individuals with autism spectrum disorder 査読有り

Miyake, N; Tsurusaki, Y; Fukai, R; Kushima, I; Okamoto, N; Ohashi, K; Nakamura, K; Hashimoto, R; Hiraki, Y; Son, S; Kato, M; Sakai, Y; Osaka, H; Deguchi, K; Matsuishi, T; Takeshita, S; Fattal-Valevski, A; Ekhilevitch, N; Tohyama, J; Yap, P; Keng, WT; Kobayashi, H; Takubo, K; Okada, T; Saitoh, S; Yasuda, Y; Murai, T; Nakamura, K; Ohga, S; Matsumoto, A; Inoue, K; Saikusa, T; Hershkovitz, T; Kobayashi, Y; Morikawa, M; Ito, A; Hara, T; Uno, Y; Seiwa, C; Ishizuka, K; Shirahata, E; Fujita, A; Koshimizu, E; Miyatake, S; Takata, A; Mizuguchi, T; Ozaki, N; Matsumoto, N

EUROPEAN JOURNAL OF HUMAN GENETICS   32 巻 ( 12 ) 頁： 1551 - 1558   2024年12月

Analysis of human neuronal cells carrying <i>ASTN2</i> deletion associated with psychiatric disorders 査読有り

Hayashi, Y; Okumura, H; Arioka, Y; Kushima, I; Mori, D; Lo, TY; Otgonbayar, G; Kato, H; Nawa, Y; Kimura, H; Aleksic, B; Ozaki, N

TRANSLATIONAL PSYCHIATRY   14 巻 ( 1 )   2024年6月

Mice with deficiency in <i>Pcdh15</i>, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature 査読有り

Mori, D; Inami, C; Ikeda, R; Sawahata, M; Urata, S; Yamaguchi, ST; Kobayashi, Y; Fujita, K; Arioka, Y; Okumura, H; Kushima, I; Kodama, A; Suzuki, T; Hirao, T; Yoshimi, A; Sobue, A; Ito, T; Noda, Y; Mizoguchi, H; Nagai, T; Kaibuchi, K; Okabe, S; Nishiguchi, K; Kume, K; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY   14 巻 ( 1 )   2024年5月

Oxytocin-induced increases in cytokines and clinical effect on the core social features of autism: Analyses of RCT datasets 査読有り

Wakuda, T; Benner, S; Uemura, Y; Nishimura, T; Kojima, M; Kuroda, M; Matsumoto, K; Kanai, C; Inada, N; Harada, T; Kameno, Y; Munesue, T; Inoue, J; Umemura, K; Yamauchi, A; Ogawa, N; Kushima, I; Suyama, S; Saito, T; Hamada, J; Kano, Y; Honda, N; Kikuchi, S; Seto, M; Tomita, H; Miyoshi, N; Matsumoto, M; Kawaguchi, Y; Kanai, K; Ikeda, M; Nakamura, I; Isomura, S; Hirano, Y; Onitsuka, T; Ozaki, N; Kosaka, H; Okada, T; Kuwabara, H; Yamasue, H

BRAIN BEHAVIOR AND IMMUNITY   118 巻   頁： 398 - 407   2024年5月

Trends in big data analyses by multicenter collaborative translational research in psychiatry. 招待有り 査読有り

Psychiatry Clin Neurosci.     2022年1月

Autism spectrum disorder comorbid with obsessive compulsive disorder and eating disorder in a woman with NBEA deletion. 査読有り

Psychiatry Clin Neurosci.     2022年1月

Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial. 査読有り

Brain     2022年

Psychiatric patients with a de novo 17q12 deletion: two case reports. 査読有り

Kushima I, Uematsu M, Ishizuka K, Aleksic B, Ozaki N.

Psychiatry Clin Neurosci.     2022年

Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia. 査読有り 国際共著

Psychiatr Genet.     2022年

Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients. 査読有り

Nawa Y, Kushima I, Aleksic B, Yamamoto M, Kimura H, Banno M, Hashimoto R, Ozaki N.

Psychiatry Clin Neurosci.     2022年

AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity. 査読有り

Front Genet.     2021年12月

Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures. 査読有り

Sci Rep.     2021年6月

Dysregulation of post-transcriptional modification by copy number variable microRNAs in schizophrenia with enhanced glycation stress. 査読有り

Transl Psychiatry     2021年5月

Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders. 査読有り

Mol Brain.     2021年4月

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial. 査読有り

Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H.

Mol Psychiatry.     2018年6月

Aberrant functional connectivity between the thalamus and visual cortex is related to attentional impairment in schizophrenia. 査読有り

Yamamoto M, Kushima I, Suzuki R, Branko A, Kawano N, Inada T, Iidaka T, Ozaki N.

Psychiatry Res Neuroimaging.     2018年6月

Single-neuron and genetic correlates of autistic behavior in macaque. 査読有り

Yoshida K, Go Y, Kushima I, Toyoda A, Fujiyama A, Imai H, Saito N, Iriki A, Ozaki N, Isoda M.

Sci Adv.   2 巻 ( 9 ) 頁： e1600558   2016年9月

ゲノム情報を起点とした精神疾患の病態研究と人工知能の活用

久島周（ 担当： 分担執筆）

臨床精神薬理  2023年2月 

重症の摂食障害におけるゲノムコピー数バリアントの寄与

久島周（ 担当： 分担執筆）

精神神経学雑誌  2023年 

精神医学・遺伝学における症例報告の意義と倫理

久島周（ 担当： 共著）

臨床精神医学  2022年2月 

自閉スペクトラム症の発症に関わる ゲノムバリアント

（ 担当： 共著）

CLINICAL NEUROSCIENCE  2022年 

精神科臨床 Legato ARHGAP10遺伝子変異と統合失調症発症の関連

（ 担当： 共著）

メディカルレビュー社  2021年3月 

統合失調症の発症と自閉スペクトラム症とのオーバーラップ

久島周（ 担当： 共著）

先端医学社  2021年3月 

「精神医学における科学的基盤」　ゲノムと精神医学―精神疾患のゲノム基盤と遺伝環境相互作用解明はどのようにして精神医学にイノベーションをもたらすか

学樹書院  2020年1月 

細胞　稀なバリアントに着目した精神疾患のゲノム研究

ニューサイエンス社  2019年12月 

分子精神医学　ヒトゲノムコピー数変異（CNV）

岩田仲生他（ 担当： 共著）

先端医学社  2015年4月 

図説　分子病態学　第5版　精神疾患：統合失調症と双極性障害

一瀬白帝他（ 担当： 共著）

中外医学社  2014年1月 

ファインケミカル　精神障害のゲノム研究

糸川昌成他（ 担当： 共著）

シーエムシー出版  2012年7月 

BRAIN and NERVE　発達期精神障害─発達障害を中心に

笠井清登他（ 担当： 共著）

医学書院  2012年 

精神医学キーワード辞典　うつ病の遺伝子・環境相関仮説

松下正明他（ 担当： 共著）

中山書店  2011年7月 

精神医学領域の論文を読みこなすキーワード100　ゲノムコピー数変異

新興医学出版社 

統合失調症への新視角 最新のゲノム解析技術による洞察

久島周

第53回日本神経精神薬理学会年会  2023年9月7日 

精神疾患のゲノム解析結果の患者・家族への還元

久島周

第119回日本精神神経学会学術総会  2023年6月24日 

頻度の稀なバリアントに基づいた精神疾患の診断　～統合失調症（SCZ）患者で見逃されている可能性がある遺伝性疾患～

久島周

第44回日本生物学的精神医学会 

精神疾患横断的に発症に関与するゲノムコピー数変異 統合失調症と自閉スペクトラム症に着目して

久島周

第43回日本生物学的精神医学会 

統合失調症のゲノム解析と診断法・治療薬開発への展開

久島周

第43回日本生物学的精神医学会  2021年7月14日 

精神疾患横断的に発症に関与するゲノムコピー数変異統合失調症と自閉スペクトラム症に着目して

日本人類遺伝学会 第65回大会  2020年11月18日  日本人類遺伝学会

統合失調症のゲノムコピー数変異（CNV）解析

久島周他

第10回日本統合失調症学会若手シンポジウム 

統合失調症のゲノムコピー数変異（CNV）解析

久島周他

第３回霊長類認知ゲノミクスワークショップ 

臨床と遺伝子像　自閉スペクトラム症（ASD）の遺伝子解析から　最近わかってきたこと

久島周他

第4回日本情動学会　シンポジウム